MCID: MLR006
MIFTS: 35

Male Reproductive Organ Cancer

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Male Reproductive Organ Cancer

MalaCards integrated aliases for Male Reproductive Organ Cancer:

Name: Male Reproductive Organ Cancer 12 15
Genital Neoplasms, Male 44 73
Malignant Neoplasm of Male Genital Organ or Tract 12
Malignant Tumor of Male Reproductive System 12
Malignant Neoplasm of Male Genital Organs 12
Malignant Neoplasm of Male Genital Organ 12
Malignant Tumor of Male Genital Organ 12
Male Reproductive System Neoplasm 12
Tumor of Male Reproductive System 12
Neoplasm of Male Genital Organ 12
Male Genital Neoplasm 12
Male Genital Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3856
ICD9CM 35 187.9
MeSH 44 D005834
NCIt 50 C3054 C8561

Summaries for Male Reproductive Organ Cancer

Disease Ontology : 12 A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum.

MalaCards based summary : Male Reproductive Organ Cancer, also known as genital neoplasms, male, is related to prostate cancer and submandibular gland cancer. An important gene associated with Male Reproductive Organ Cancer is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Glioma and Gastric cancer. Related phenotypes are endocrine/exocrine gland and adipose tissue

Related Diseases for Male Reproductive Organ Cancer

Diseases related to Male Reproductive Organ Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 prostate cancer 30.3 AKT1 AMACR AR CDH1 CYP17A1 FOLH1
2 submandibular gland cancer 11.2 KLK3 TP53
3 nodular prostate 11.1 AR FOLH1 KLK3
4 rare adenocarcinoma of the breast 11.1 AKT1 TP53
5 urethral diverticulum 11.1 AMACR KLK3 NKX3-1
6 bartholin's duct cyst 11.0 AR TP53
7 female breast cancer 11.0 AR KLK3 TP53
8 prostate sarcoma 11.0 KLK3 NKX3-1
9 atrophy of prostate 11.0 KLK3 TP53
10 prostatic acinar adenocarcinoma 11.0 AMACR AR KLK3 TMPRSS2
11 clear cell adenocarcinoma 11.0 AMACR KLK3 TP53
12 prostatic hyperplasia, benign 11.0 AR FOLH1 KLK3 PSCA
13 seminal vesicle adenocarcinoma 11.0
14 littre gland carcinoma 11.0
15 cowper gland carcinoma 11.0
16 small cell carcinoma 11.0 KLK3 PTEN TMPRSS2 TP53
17 pharynx cancer 11.0 AKT1 CDH1 TP53
18 anaplastic thyroid cancer 11.0 CDH1 PTEN TP53
19 endometrial adenocarcinoma 11.0 AKT1 PTEN TP53
20 testicular germ cell tumor 11.0 AKT1 AR PTEN TP53
21 cerebral convexity meningioma 11.0 CDH1 TP53
22 gastrointestinal system benign neoplasm 11.0 AREG CDH1 TP53
23 intestinal benign neoplasm 10.9 AREG CDH1 TP53
24 salivary gland cancer 10.9 AKT1 AREG PTEN
25 reproductive system disease 10.9 AR AREG KLK3
26 ductal carcinoma in situ 10.9 AKT1 AR CDH1 TP53
27 bladder urothelial carcinoma 10.9 AKT1 CDH1 KLK3 TP53
28 renal cell carcinoma, papillary, 1 10.9 AMACR PTEN TP53
29 chordoma 10.9 CDH1 PTEN TP53
30 transitional cell carcinoma 10.9 CDH1 PSCA PTEN TP53
31 adenoid cystic carcinoma 10.9 AKT1 CDH1 PTEN TP53
32 ovarian cancer 1 10.9 AKT1 AREG CDH1 TP53
33 malignant ovarian surface epithelial-stromal neoplasm 10.9 AKT1 AREG CDH1 TP53
34 ovary epithelial cancer 10.9 AKT1 AREG CDH1 TP53
35 oral cavity cancer 10.9 AREG CDH1 PTEN TP53
36 adamantinoma of long bones 10.9 CDH1 KLK3 PTEN TP53
37 vulvar intraepithelial neoplasia 10.9 CDH1 TP53
38 small cell cancer of the lung 10.8 AKT1 GRP PTEN TP53
39 lung squamous cell carcinoma 10.8 AKT1 CDH1 PTEN TP53
40 uterine carcinosarcoma 10.8 CDH1 PTEN TP53
41 breast ductal carcinoma 10.8 AR CDH1 TP53
42 endocrine gland cancer 10.8 AKT1 AR AREG CDH1 TP53
43 female reproductive organ cancer 10.8 AKT1 AREG CDH1 PTEN TP53
44 gastrointestinal system cancer 10.8 AKT1 AREG CDH1 PTEN TP53
45 female reproductive endometrioid cancer 10.8 PTEN TP53
46 pancreas adenocarcinoma 10.7 AKT1 AREG CDH1 PSCA TP53
47 prostatic adenoma 10.7 AR KLK3
48 squamous cell carcinoma, head and neck 10.7 AKT1 AREG CDH1 PTEN TP53
49 tongue squamous cell carcinoma 10.7 AKT1 CDH1 TP53
50 cell type cancer 10.7 AKT1 AREG CDH1 KLK3 PTEN TP53

Graphical network of the top 20 diseases related to Male Reproductive Organ Cancer:



Diseases related to Male Reproductive Organ Cancer

Symptoms & Phenotypes for Male Reproductive Organ Cancer

MGI Mouse Phenotypes related to Male Reproductive Organ Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.81 AR AREG CDH1 NKX3-1 PTEN RNASEL
2 adipose tissue MP:0005375 9.73 TP53 AKT1 AMACR AR CYP17A1 PTEN
3 neoplasm MP:0002006 9.56 AR CDH1 NKX3-1 PSCA PTEN TMPRSS2
4 reproductive system MP:0005389 9.28 AR AREG CDH1 CYP17A1 NKX3-1 PTEN

Drugs & Therapeutics for Male Reproductive Organ Cancer

Search Clinical Trials , NIH Clinical Center for Male Reproductive Organ Cancer

Cochrane evidence based reviews: genital neoplasms, male

Genetic Tests for Male Reproductive Organ Cancer

Anatomical Context for Male Reproductive Organ Cancer

Publications for Male Reproductive Organ Cancer

Variations for Male Reproductive Organ Cancer

Expression for Male Reproductive Organ Cancer

Search GEO for disease gene expression data for Male Reproductive Organ Cancer.

Pathways for Male Reproductive Organ Cancer

Pathways related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 AKT1 CDH1 PTEN SHC4 TP53
2
Show member pathways
12.64 AKT1 CDH1 PTEN SHC4 TP53
3
Show member pathways
12.58 AKT1 CDH1 PTEN SHC4 TP53
4 12.52 AKT1 AR CDH1 KLK3 NKX3-1 PTEN
5
Show member pathways
12.36 AKT1 CYP17A1 PTEN SHC4
6
Show member pathways
12.35 AKT1 AREG SHC4 TP53
7
Show member pathways
12.29 AKT1 AREG CDH1 SHC4 TP53
8
Show member pathways
12.11 AKT1 PSMA1 PTEN TP53
9
Show member pathways
12.08 AKT1 AREG PTEN SHC4
10
Show member pathways
12.07 AKT1 AR AREG CDH1 KLK3 NKX3-1
11 11.91 AKT1 AR CDH1 PTEN TP53
12
Show member pathways
11.9 AKT1 AR KLK3 PTEN
13 11.82 PTEN RNASEL TP53
14 11.74 AKT1 PTEN TP53
15 11.7 AKT1 PTEN TP53
16 11.63 AKT1 AR KLK3 PTEN
17 11.56 AKT1 PTEN TP53
18 11.55 AKT1 PTEN TP53
19 11.42 AKT1 PTEN TP53
20 11.35 KLK2 KLK3 KLK4
21
Show member pathways
11.32 AR KLK3 NKX3-1
22 11.3 AKT1 PTEN TP53
23 11.19 AKT1 AR KLK2 KLK3 NKX3-1 TMPRSS2
24 11.16 AR KLK2 KLK3 TMPRSS2

GO Terms for Male Reproductive Organ Cancer

Cellular components related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.8 KLK2 KLK3 KLK4

Biological processes related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.95 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
2 protein deubiquitination GO:0016579 9.85 AR PSMA1 PTEN TP53
3 positive regulation of gene expression GO:0010628 9.8 AKT1 AR NKX3-1 PTEN TP53
4 cell proliferation GO:0008283 9.77 AKT1 AR AREG PTEN TP53
5 response to organic substance GO:0010033 9.73 AKT1 CDH1 PTEN
6 extracellular matrix disassembly GO:0022617 9.69 CDH1 KLK2 KLK4
7 negative regulation of epithelial cell proliferation GO:0050680 9.63 AR NKX3-1 PTEN
8 positive regulation of cell proliferation GO:0008284 9.63 AKT1 AR AREG NKX3-1 PTEN SHC4
9 mammary gland alveolus development GO:0060749 9.58 AR AREG
10 acute inflammatory response GO:0002526 9.58 KLK2 KLK3
11 prostate gland development GO:0030850 9.57 AR NKX3-1
12 zymogen activation GO:0031638 9.54 KLK2 KLK3
13 cellular response to steroid hormone stimulus GO:0071383 9.52 AR NKX3-1
14 protein kinase B signaling GO:0043491 9.5 AKT1 NKX3-1 PTEN
15 negative regulation of cell size GO:0045792 9.49 AKT1 PTEN
16 prostate gland growth GO:0060736 9.43 AR PTEN
17 cellular response to decreased oxygen levels GO:0036294 9.26 AKT1 PTEN
18 cellular response to hypoxia GO:0071456 9.26 AKT1 NKX3-1 PTEN TP53
19 regulation of systemic arterial blood pressure GO:0003073 8.8 AR KLK2 KLK3

Molecular functions related to Male Reproductive Organ Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.86 FOLH1 KLK2 KLK3 KLK4 PSMA1 PTEN
2 serine-type endopeptidase activity GO:0004252 9.62 KLK2 KLK3 KLK4 TMPRSS2
3 serine-type peptidase activity GO:0008236 9.46 KLK2 KLK3 KLK4 TMPRSS2
4 peptidase activity GO:0008233 9.43 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
5 GTPase activating protein binding GO:0032794 9.37 AKT1 CDH1
6 androgen receptor activity GO:0004882 8.62 AR NKX3-1

Sources for Male Reproductive Organ Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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