MCID: MLR007
MIFTS: 40

Male Reproductive System Disease

Categories: Reproductive diseases

Aliases & Classifications for Male Reproductive System Disease

MalaCards integrated aliases for Male Reproductive System Disease:

Name: Male Reproductive System Disease 12 15
Disorder of Male Reproductive System 73
Genital Diseases, Male 44

Classifications:



External Ids:

Disease Ontology 12 DOID:48
ICD10 33 N50.9
MeSH 44 D005832
SNOMED-CT 68 64557000

Summaries for Male Reproductive System Disease

Disease Ontology : 12 A reproductive system disease that affects male reproductive organs.

MalaCards based summary : Male Reproductive System Disease, also known as disorder of male reproductive system, is related to submandibular gland cancer and nodular prostate, and has symptoms including nipple discharge, pain in scrotum and pain in testicle. An important gene associated with Male Reproductive System Disease is KLK3 (Kallikrein Related Peptidase 3), and among its related pathways/superpathways are Pathways in cancer and Glucose / Energy Metabolism. Affiliated tissues include prostate, lung and colon, and related phenotypes are adipose tissue and neoplasm

Related Diseases for Male Reproductive System Disease

Diseases related to Male Reproductive System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 submandibular gland cancer 10.4 KLK3 TP53
2 nodular prostate 10.4 AR FOLH1 KLK3
3 small cell carcinoma 10.4 KLK3 PTEN TP53
4 nephrogenic adenoma 10.3 AMACR KLK3 NKX3-1
5 oligospermia 10.3 AR DAZ1 DAZ4
6 urethral diverticulum 10.3 AMACR KLK3 NKX3-1
7 prostatic hyperplasia, benign 10.3 AR CYP17A1 FOLH1 KLK3
8 prostate small cell carcinoma 10.3 AMACR FOLH1 KLK3 PTEN
9 partial deletion of y 10.3 DAZ1 DAZ4
10 prostatic acinar adenocarcinoma 10.3 AMACR KLK3 NKX3-1 TMPRSS2
11 bartholin's duct cyst 10.3 AR TP53
12 supratentorial cancer 10.3 AKT1 PTEN TP53
13 cerebrum cancer 10.3 AKT1 PTEN TP53
14 bladder disease 10.3 AKT1 KLK3 TP53
15 atrophy of prostate 10.3 KLK3 TP53
16 ovarian cancer 1 10.3 AKT1 AREG TP53
17 ductal carcinoma in situ 10.3 AKT1 AR TP53
18 malignant ovarian surface epithelial-stromal neoplasm 10.3 AKT1 AREG TP53
19 prostate sarcoma 10.3 KLK3 NKX3-1
20 bladder urothelial carcinoma 10.3 AKT1 AR KLK3 TP53
21 ovary epithelial cancer 10.3 AKT1 AREG TP53
22 connective tissue cancer 10.3 AKT1 AREG TP53
23 central nervous system cancer 10.3 AKT1 PTEN TP53
24 gonadal disease 10.3 AKT1 AR AREG TP53
25 nervous system cancer 10.3 AKT1 PTEN TP53
26 pancreas disease 10.3 AKT1 AREG TP53
27 cervix disease 10.3 AKT1 AREG TLR9 TP53
28 colonic disease 10.3 AKT1 AREG TLR9 TP53
29 stomach disease 10.3 AKT1 AREG TLR9 TP53
30 rare adenocarcinoma of the breast 10.3 AKT1 TP53
31 oral cavity cancer 10.3 AREG PTEN TLR9 TP53
32 leukocyte disease 10.3 AKT1 TLR9 TP53
33 intestinal disease 10.3 AKT1 AREG TLR9 TP53
34 respiratory system disease 10.3 AKT1 AREG TLR9 TP53
35 pharynx squamous cell carcinoma 10.3 AKT1 PTEN
36 gastrointestinal system disease 10.3 AKT1 AREG TLR9 TP53
37 endometrial adenocarcinoma 10.3 AKT1 PTEN TP53
38 uterine anomalies 10.3 AKT1 AREG PTEN TLR9 TP53
39 female reproductive system disease 10.3 AKT1 AREG PTEN TLR9 TP53
40 respiratory system cancer 10.3 AKT1 AREG PTEN TLR9 TP53
41 gastrointestinal system cancer 10.3 AKT1 AREG PTEN TLR9 TP53
42 large intestine cancer 10.2 AKT1 AREG PTEN TLR9 TP53
43 endocrine gland cancer 10.2 AKT1 AR AREG PTEN TLR9 TP53
44 renal cell carcinoma, papillary, 1 10.2 AMACR PTEN TP53
45 suppression of tumorigenicity 12 10.2 AKT1 AMACR AR FOLH1 KLK3 NKX3-1
46 squamous cell carcinoma, head and neck 10.2 AKT1 AREG PTEN TP53
47 meningioma, familial 10.2 AKT1 PTEN TP53
48 endometrial cancer 10.1 AKT1 AR AREG PTEN TP53
49 breast adenocarcinoma 10.1 AKT1 PTEN TP53
50 prostate cancer 10.0 AKT1 AMACR AR CYP17A1 FOLH1 KLK2

Graphical network of the top 20 diseases related to Male Reproductive System Disease:



Diseases related to Male Reproductive System Disease

Symptoms & Phenotypes for Male Reproductive System Disease

UMLS symptoms related to Male Reproductive System Disease:


nipple discharge, pain in scrotum, pain in testicle, perineal pain male

MGI Mouse Phenotypes related to Male Reproductive System Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.43 AKT1 AMACR AR CYP17A1 PTEN TP53
2 neoplasm MP:0002006 9.1 AKT1 AR NKX3-1 PTEN TMPRSS2 TP53

Drugs & Therapeutics for Male Reproductive System Disease

Search Clinical Trials , NIH Clinical Center for Male Reproductive System Disease

Cochrane evidence based reviews: genital diseases, male

Genetic Tests for Male Reproductive System Disease

Anatomical Context for Male Reproductive System Disease

MalaCards organs/tissues related to Male Reproductive System Disease:

41
Prostate, Lung, Colon, Testes, Ovary, Pancreas, Thyroid

Publications for Male Reproductive System Disease

Variations for Male Reproductive System Disease

Expression for Male Reproductive System Disease

Search GEO for disease gene expression data for Male Reproductive System Disease.

Pathways for Male Reproductive System Disease

Pathways related to Male Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1 12.52 AKT1 AR KLK3 NKX3-1 PTEN TP53
2 12.38 AKT1 AMACR CYP17A1 PTEN
3
Show member pathways
12.35 AKT1 AR AREG KLK3 NKX3-1 PTEN
4
Show member pathways
12.34 AKT1 CYP17A1 PTEN SHC4
5
Show member pathways
12.32 AKT1 AREG SHC4 TP53
6
Show member pathways
12.07 AKT1 PSMA1 PTEN TP53
7
Show member pathways
12.06 AKT1 AREG PTEN SHC4
8 11.89 AKT1 AR PTEN TP53
9
Show member pathways
11.83 AKT1 AR KLK3 PTEN
10 11.82 AKT1 PTEN TP53
11 11.71 AKT1 PTEN TP53
12 11.66 AKT1 PTEN TP53
13 11.54 AKT1 PTEN TP53
14 11.53 AKT1 PTEN TP53
15 11.52 AKT1 AR KLK3 PTEN
16 11.43 AKT1 PTEN TP53
17 11.33 KLK2 KLK3 KLK4
18
Show member pathways
11.3 AR KLK3 NKX3-1
19 11.27 AKT1 PTEN TP53
20 11.16 AR KLK2 KLK3 TMPRSS2
21 10.86 AKT1 AR KLK2 KLK3 NKX3-1 TMPRSS2

GO Terms for Male Reproductive System Disease

Cellular components related to Male Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 9.13 KLK2 KLK3 KLK4
2 protein-containing complex GO:0032991 9.1 AKT1 AR DAZ1 DAZ4 KLK3 TP53

Biological processes related to Male Reproductive System Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.95 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
2 protein deubiquitination GO:0016579 9.83 AR PSMA1 PTEN TP53
3 cell proliferation GO:0008283 9.83 AKT1 AR AREG PTEN TP53
4 positive regulation of cell proliferation GO:0008284 9.73 AKT1 AR AREG NKX3-1 PTEN SHC4
5 negative regulation of epithelial cell proliferation GO:0050680 9.67 AR NKX3-1 PTEN
6 mammary gland alveolus development GO:0060749 9.57 AR AREG
7 zymogen activation GO:0031638 9.56 KLK2 KLK3
8 prostate gland development GO:0030850 9.55 AR NKX3-1
9 cellular response to steroid hormone stimulus GO:0071383 9.54 AR NKX3-1
10 germ cell development GO:0007281 9.54 AKT1 DAZ1 DAZ4
11 negative regulation of cell size GO:0045792 9.51 AKT1 PTEN
12 protein kinase B signaling GO:0043491 9.5 AKT1 NKX3-1 PTEN
13 prostate gland growth GO:0060736 9.46 AR PTEN
14 cellular response to hypoxia GO:0071456 9.46 AKT1 NKX3-1 PTEN TP53
15 positive regulation of gene expression GO:0010628 9.43 AKT1 AR NKX3-1 PTEN TLR9 TP53
16 cellular response to decreased oxygen levels GO:0036294 9.4 AKT1 PTEN
17 regulation of systemic arterial blood pressure GO:0003073 8.8 AR KLK2 KLK3

Molecular functions related to Male Reproductive System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.62 KLK2 KLK3 KLK4 TMPRSS2
2 serine-type peptidase activity GO:0008236 9.46 KLK2 KLK3 KLK4 TMPRSS2
3 mRNA 3'-UTR binding GO:0003730 9.43 DAZ1 DAZ4 TP53
4 translation activator activity GO:0008494 9.37 DAZ1 DAZ4
5 peptidase activity GO:0008233 9.1 FOLH1 KLK2 KLK3 KLK4 PSMA1 TMPRSS2
6 androgen receptor activity GO:0004882 8.96 AR NKX3-1

Sources for Male Reproductive System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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