MCID: MLG048
MIFTS: 34

Malignant Acrospiroma

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Malignant Acrospiroma

MalaCards integrated aliases for Malignant Acrospiroma:

Name: Malignant Acrospiroma 12 20 15
Eccrine Ductal Carcinoma 12 70
Hidradenocarcinoma 20 17
Primary Mucoepidermoid Cutaneous Carcinoma 20
Malignant Nodular/clear Cell Hidradenoma 20
Eccrine Ductal Carcinoma of Skin 12
Malignant Clear Cell Acrospiroma 20
Clear Cell Eccrine Carcinoma 20
Sweat Gland Adenocarcinoma 70
Anaplastic Syringoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5570
NCIt 50 C43345
SNOMED-CT 67 403939009
UMLS 70 C0334344 C1260964

Summaries for Malignant Acrospiroma

GARD : 20 Hidradenocarcinoma is a rare tumor caused by the abnormal growth of cells in a sweat gland. It is a type of cancer that usually begins as a single spot ( lesion ) on the skin of the head or neck, but can be been found on other parts of the body. This type of tumor most often develops in people between the ages of 30-60 years old, but has been found in children. Hidradenocarcinoma is usually painless and tends to grow slowly, but may spread into nearby tissues, especially lymph nodes, or to more distant parts of the body ( metastasis ). The cause of the tumor is unknown. Diagnosis is usually made by careful examination and a series of special skin tests. The main treatment is surgical removal of the tumor often followed by radiation therapy and/or chemotherapy. Long term outlook is best when the cancer is found early.

MalaCards based summary : Malignant Acrospiroma, also known as eccrine ductal carcinoma, is related to eccrine porocarcinoma and nodular hidradenoma. An important gene associated with Malignant Acrospiroma is CEACAM5 (CEA Cell Adhesion Molecule 5). Affiliated tissues include breast, skin and lung.

Wikipedia : 73 A malignant acrospiroma is a sweat gland carcinoma of the hand, which may recur locally in 50% of... more...

Related Diseases for Malignant Acrospiroma

Diseases related to Malignant Acrospiroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
# Related Disease Score Top Affiliating Genes
1 eccrine porocarcinoma 31.2 MAML2 KRT7 CEACAM5
2 nodular hidradenoma 30.2 PIP CEACAM5
3 mammary paget's disease 29.8 PIP KRT7
4 sweat gland cancer 29.1 PIP KRT7 KRT5 CEACAM5
5 hidradenoma 29.0 PIP PHLDA1 MAML2 KRT7 KRT5 CEACAM5
6 malignant syringoma 29.0 PIP PHLDA1 KRT7 KRT5 CEACAM5
7 clear cell hidradenoma 29.0 PIP MAML2 KRT7 KRT5 CEACAM5
8 skin carcinoma 28.7 PIP PHLDA1 KRT7 KRT5 CEACAM5
9 eccrine acrospiroma 28.7 PIP MAML2 KRT7 KRT5 CEACAM5
10 vulvar clear cell hidradenocarcinoma 11.1
11 spondyloepiphyseal dysplasia congenita 10.5
12 hair whorl 10.2
13 fox-fordyce disease 10.2 PIP CEACAM5
14 vulvar eccrine porocarcinoma 10.2 PIP CEACAM5
15 aggressive digital papillary adenocarcinoma 10.1 PHLDA1 MAML2
16 mucoepidermoid esophageal carcinoma 10.1 KRT5 CEACAM5
17 breast cystic hypersecretory carcinoma 10.1 KRT5 CEACAM5
18 gallbladder squamous cell carcinoma 10.1 KRT5 CEACAM5
19 thymus adenocarcinoma 10.1 KRT5 CEACAM5
20 vulva basal cell carcinoma 10.1 KRT5 CEACAM5
21 colon leiomyosarcoma 10.1 KRT5 CEACAM5
22 intracystic papillary adenoma 10.1 KRT5 CEACAM5
23 breast mucoepidermoid carcinoma 10.0 MAML2 KRT5
24 leukemia, chronic lymphocytic 10.0
25 helix syndrome 10.0
26 squamous cell carcinoma 10.0
27 breast secretory carcinoma 10.0 PIP KRT5
28 lipid-rich carcinoma 10.0 PIP KRT5
29 syringoma 10.0 KRT7 CEACAM5
30 posttransplant acute limbic encephalitis 10.0
31 cystadenocarcinoma 10.0 KRT7 CEACAM5
32 leukoplakia of penis 10.0 KRT7 CEACAM5
33 rare tumor 10.0
34 urethral villous adenoma 10.0 KRT7 CEACAM5
35 villous adenoma 10.0 KRT7 CEACAM5
36 mucinous adenofibroma 10.0 KRT7 CEACAM5
37 pancreatic foamy gland adenocarcinoma 10.0 KRT7 CEACAM5
38 pancreatic serous cystadenocarcinoma 10.0 KRT7 CEACAM5
39 urinary bladder villous adenoma 10.0 KRT7 CEACAM5
40 vaginal tubulovillous adenoma 10.0 KRT7 CEACAM5
41 female urethral cancer 10.0 KRT7 CEACAM5
42 renal pelvis adenocarcinoma 10.0 KRT7 CEACAM5
43 bile duct cystadenocarcinoma 10.0 KRT7 CEACAM5
44 mucinous ovarian cystadenoma 10.0 KRT7 CEACAM5
45 ovarian cystadenoma 10.0 KRT7 CEACAM5
46 cystadenoma 10.0 KRT7 CEACAM5
47 rectosigmoid junction neoplasm 10.0 KRT7 CEACAM5
48 transverse colon cancer 10.0 KRT7 CEACAM5
49 sigmoid neoplasm 10.0 KRT7 CEACAM5
50 krukenberg carcinoma 10.0 KRT7 CEACAM5

Graphical network of the top 20 diseases related to Malignant Acrospiroma:



Diseases related to Malignant Acrospiroma

Symptoms & Phenotypes for Malignant Acrospiroma

Drugs & Therapeutics for Malignant Acrospiroma

Search Clinical Trials , NIH Clinical Center for Malignant Acrospiroma

Genetic Tests for Malignant Acrospiroma

Anatomical Context for Malignant Acrospiroma

MalaCards organs/tissues related to Malignant Acrospiroma:

40
Breast, Skin, Lung, Thymus, Liver, Lymph Node, Colon

Publications for Malignant Acrospiroma

Articles related to Malignant Acrospiroma:

(show top 50) (show all 131)
# Title Authors PMID Year
1
Cutaneous hidradenocarcinoma: a clinicopathological, immunohistochemical, and molecular biologic study of 14 cases, including Her2/neu gene expression/amplification, TP53 gene mutation analysis, and t(11;19) translocation. 61 20
19384064 2009
2
Metastatic hidradenocarcinoma with demonstration of Her-2/neu gene amplification by fluorescence in situ hybridization: potential treatment implications. 20 61
17214855 2007
3
Hidradenocarcinomas: a brief review and future directions. 20
20441512 2010
4
Hidradenocarcinoma. 61
33597101 2021
5
Exceptional response to anti-PD-1 treatment in a patient with metastatic cutaneous hidradenocarcinoma. 61
33465705 2021
6
Hidradenocarcinoma: a rare but challenging diagnosis. 61
33549922 2021
7
NUT Is a Specific Immunohistochemical Marker for the Diagnosis of YAP1-NUTM1-rearranged Cutaneous Poroid Neoplasms. 61
33739783 2021
8
Three Cases of Clear Cell Hidradenoma With "Benign" Lymph Node Involvement. 61
33464750 2021
9
Surgical management and lymph-node biopsy of rare malignant cutaneous adnexal carcinomas: a population-based analysis of 7591 patients. 61
32965516 2020
10
Periungual hidradenocarcinoma mimicking squamous cell carcinoma: A rare presentation with dermatoscopic findings. 61
32406141 2020
11
Second primary malignancies in patients with hidradenocarcinoma: a US national database study. 61
31541477 2020
12
A Case for a Local Flap as Primary Reconstruction for Hidradenocarcinoma of the Leg. 61
33133887 2020
13
Clinicopathological correlation of malignant skin tumors: A retrospective study of 5 years. 61
32536845 2020
14
Poroid Hidradenocarcinoma of the Ankle: Case Report of a Rare Malignant Cutaneous Adnexal Neoplasm. 61
32131015 2020
15
Malignant Hidradenocarcinoma of the Axilla. 61
32226692 2020
16
Objective Clinical and Radiological Response under Sunitinib in a Case of Thigh Hidradenocarcinoma. 61
32158575 2020
17
An Unusual Case of Lower Extremity Clear Cell Hidradenocarcinoma. 61
32328335 2020
18
Clear cell hidradenoma of the hand: A case report in an 83-year old patient. 61
32979831 2020
19
Hidradenocarcinoma of the Scrotum. 61
31302136 2019
20
Incisional biopsy critical in obtaining definitive diagnosis in a clinically challenging case. 61
31046907 2019
21
Malignant Sweat Gland Tumors. 61
30497677 2019
22
[Epidemiological and anatomoclinical features of scalp tumors in black Africans]. 61
31934241 2019
23
[Trichilemmal carcinoma in a patient with squamous cell skin cancer]. 61
30830102 2019
24
A rare presentation of hidradenocarcinoma within the penis. 61
30510902 2019
25
Sebaceous tumours: more than skin deep. 61
29247065 2018
26
Hidradenocarcinoma: Five Years of Local and Systemic Control of a Rare Sweat Gland Neoplasm with Nodal Metastasis. 61
30155386 2018
27
Malignant Hidradenocarcinoma in the Lower Extremity: A Case Report of a Rare Tumor. 61
29472169 2018
28
[Hidradenocarcinoma of the Scrotum with Lymph Node Metastasis]. 61
29790470 2018
29
18F-FDG PET/CT Imaging of Hidradenocarcinoma Arising From Preexisting Hidradenoma of the Knee. 61
29166328 2018
30
Complete response in a patient with gynecological hidradenocarcinoma treated with exclusive external beam radiotherapy and brachytherapy: a case report. 61
29441103 2017
31
Adnexal Carcinomas Treated With Mohs Micrographic Surgery: A Comprehensive Review. 61
28445202 2017
32
Fatal hidradenocarcinoma of the scalp: A case report. 61
28410954 2017
33
Translocation of the MAML2 gene in hidradenocarcinoma. 61
28295544 2017
34
[Hidradenocarcinoma of the heel associated with inguinal metastases]. 61
28528731 2017
35
Hidradenocarcinoma of the Dorsum of the Hand. 61
28685735 2017
36
Malignant acrospiroma: a case report in the era of next generation sequencing. 61
28347286 2017
37
Retrospective study of rare cutaneous malignant adnexal tumors of the head and neck in a tertiary care cancer hospital: a case series. 61
28284233 2017
38
Hidradenocarcinoma of the finger: a rare tumor, mimicking a giant cell tumor of the tendon sheath. 61
26319286 2016
39
Case report: clear cell hidradenocarcinoma of the nail bed. 61
26416223 2016
40
Lymph node location of a clear cell hidradenoma: report of a patient and review of literature. 61
27080562 2016
41
Hidradenocarcinoma presenting as soft tissue mass: Case report with cytomorphologic description, histologic correlation, and differential diagnosis. 61
26876052 2016
42
Managing a Rare Malignant Sweat Gland Tumor Invading the Brain: Case Report and Literature Review. 61
26410201 2016
43
Malignant sweat gland tumours: an update. 61
26114606 2015
44
Management of Metastatic Apocrine Hidradenocarcinoma with Chemotherapy and Radiation. 61
26500736 2015
45
Hidradenocarcinoma: A Rare Sweat Gland Neoplasm Presenting as Small Turban Tumor of the Scalp. 61
26288440 2015
46
Mohs micrographic surgery for the treatment of hidradenocarcinoma: the Mayo Clinic experience from 1993 to 2013. 61
25627632 2015
47
Whole exome sequencing of a patient with metastatic hidradenocarcinoma and review of the literature. 61
25918615 2015
48
Current management approach to hidradenocarcinoma: a comprehensive review of the literature. 61
25815059 2015
49
Hidradenocarcinoma: a sinister diagnosis of a suspected benign condition. 61
25513929 2014
50
Hidradenocarcinoma of the chest. 61
25382529 2014

Variations for Malignant Acrospiroma

Cosmic variations for Malignant Acrospiroma:

9 (show top 50) (show all 540)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM106059757 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
2 COSM112354551 TP53 skin,hand,carcinoma,NS c.565G>A p.A189T 17:7674966-7674966 6
3 COSM111759858 TP53 skin,hand,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 6
4 COSM143943797 TP53 skin,neck,carcinoma,NS c.266G>A p.R89Q 17:7674220-7674220 6
5 COSM145161899 TP53 skin,hand,carcinoma,NS c.833A>G p.Q278R 17:7673578-7673578 6
6 COSM112254266 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
7 COSM145019215 TP53 skin,hand,carcinoma,NS c.739G>A p.E247K 17:7673764-7673764 6
8 COSM144309924 TP53 skin,hand,carcinoma,NS c.701G>A p.R234H 17:7673802-7673802 6
9 COSM142560281 TP53 skin,neck,carcinoma,NS c.626G>A p.R209Q 17:7674220-7674220 6
10 COSM144087977 TP53 skin,hand,carcinoma,NS c.379G>A p.E127K 17:7673764-7673764 6
11 COSM93190386 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
12 COSM106059965 TP53 skin,hand,carcinoma,NS c.647T>A p.V216E 17:7674884-7674884 6
13 COSM105621918 TP53 skin,hand,carcinoma,NS c.782+417G>A p.? 17:7673764-7673764 6
14 COSM143386984 TP53 skin,hand,carcinoma,NS c.193C>T p.Q65* 17:7676059-7676059 6
15 COSM122787283 TP53 skin,hand,carcinoma,NS c.449G>C p.R150P 17:7673775-7673775 6
16 COSM144213765 TP53 skin,hand,carcinoma,NS c.473A>G p.Q158R 17:7673578-7673578 6
17 COSM111765517 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
18 COSM142560894 TP53 skin,hand,carcinoma,NS c.556-1G>A p.? 17:7674291-7674291 6
19 COSM87899076 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
20 COSM145018355 TP53 skin,hand,carcinoma,NS c.556-1G>A p.? 17:7674291-7674291 6
21 COSM143465962 TP53 skin,hand,carcinoma,NS c.448G>A p.A150T 17:7674966-7674966 6
22 COSM144651848 TP53 skin,hand,carcinoma,NS c.556-1G>A p.? 17:7674291-7674291 6
23 COSM105636071 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6
24 COSM144087106 TP53 skin,neck,carcinoma,NS c.266G>A p.R89Q 17:7674220-7674220 6
25 COSM144311386 TP53 skin,hand,carcinoma,NS c.739G>A p.E247K 17:7673764-7673764 6
26 COSM106053786 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
27 COSM144757328 TP53 skin,hand,carcinoma,NS c.448G>A p.A150T 17:7674966-7674966 6
28 COSM143945161 TP53 skin,hand,carcinoma,NS c.379G>A p.E127K 17:7673764-7673764 6
29 COSM87899887 TP53 skin,hand,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 6
30 COSM121884502 TP53 skin,hand,carcinoma,NS c.251T>A p.V84E 17:7674884-7674884 6
31 COSM144310203 TP53 skin,neck,carcinoma,NS c.626G>A p.R209Q 17:7674220-7674220 6
32 COSM144315643 TP53 skin,hand,carcinoma,NS c.143C>A p.P48Q 17:7676109-7676109 6
33 COSM142837352 TP53 skin,neck,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 6
34 COSM142566904 TP53 skin,hand,carcinoma,NS c.530T>A p.V177E 17:7674884-7674884 6
35 COSM111807840 TP53 skin,hand,carcinoma,NS c.845G>C p.R282P 17:7673775-7673775 6
36 COSM144652672 TP53 skin,hand,carcinoma,NS c.739G>A p.E247K 17:7673764-7673764 6
37 COSM143000079 TP53 skin,hand,carcinoma,NS c.590T>C p.V197A 17:7674941-7674941 6
38 COSM145017657 TP53 skin,neck,carcinoma,NS c.626G>A p.R209Q 17:7674220-7674220 6
39 COSM105621045 TP53 skin,hand,carcinoma,NS c.673-1G>A p.? 17:7674291-7674291 6
40 COSM93198616 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6
41 COSM105627660 TP53 skin,hand,carcinoma,NS c.647T>A p.V216E 17:7674884-7674884 6
42 COSM144650760 TP53 skin,hand,carcinoma,NS c.701G>A p.R234H 17:7673802-7673802 6
43 COSM111909038 TP53 skin,hand,carcinoma,NS c.950A>G p.Q317R 17:7673578-7673578 6
44 COSM144087357 TP53 skin,hand,carcinoma,NS c.83-1G>A p.? 17:7674972-7674972 6
45 COSM106067323 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6
46 COSM144014790 TP53 skin,hand,carcinoma,NS c.823G>A p.E275K 17:7673764-7673764 6
47 COSM122278245 TP53 skin,hand,carcinoma,NS c.251T>A p.V84E 17:7674884-7674884 6
48 COSM122740574 TP53 skin,hand,carcinoma,NS c.251T>A p.V84E 17:7674884-7674884 6
49 COSM105627464 TP53 skin,hand,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 6
50 COSM112268626 TP53 skin,hand,carcinoma,NS c.310C>T p.Q104* 17:7676059-7676059 6

Expression for Malignant Acrospiroma

Search GEO for disease gene expression data for Malignant Acrospiroma.

Pathways for Malignant Acrospiroma

GO Terms for Malignant Acrospiroma

Sources for Malignant Acrospiroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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