MCID: MLG038
MIFTS: 29

Malignant Anus Melanoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases

Aliases & Classifications for Malignant Anus Melanoma

MalaCards integrated aliases for Malignant Anus Melanoma:

Name: Malignant Anus Melanoma 12 15
Malignant Melanoma of Anus 12 71
Anal Melanoma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:14145
NCIt 49 C4639
UMLS 71 C0349538

Summaries for Malignant Anus Melanoma

MalaCards based summary : Malignant Anus Melanoma, also known as malignant melanoma of anus, is related to hemorrhoid and intussusception. An important gene associated with Malignant Anus Melanoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Pathways in cancer. Affiliated tissues include colon, skin and bone, and related phenotype is pigmentation.

Related Diseases for Malignant Anus Melanoma

Diseases related to Malignant Anus Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 hemorrhoid 30.4 MLANA APOLD1
2 intussusception 30.0 KIT APOLD1
3 amelanotic melanoma 30.0 MLANA KIT
4 skin melanoma 29.0 NRAS MLANA HRAS GNAQ
5 mucosal melanoma 28.7 NRAS MAGEC2 MAGEC1 KIT GNAQ
6 melanoma 27.9 NRAS MLANA MAGEC2 MAGEC1 KIT HRAS
7 selection of therapeutic option in melanoma 10.3 NRAS KIT
8 vagina leiomyosarcoma 10.3 MLANA KIT
9 small intestine leiomyoma 10.3 MLANA KIT
10 jejunal neoplasm 10.3 MLANA KIT
11 conventional fibrosarcoma 10.3 NRAS KIT
12 retroperitoneal sarcoma 10.3 MLANA KIT
13 melanoma in congenital melanocytic nevus 10.3 NRAS MLANA
14 thymus clear cell carcinoma 10.3 MLANA KIT
15 vagina sarcoma 10.3 MLANA KIT
16 undifferentiated pleomorphic sarcoma 10.2 MLANA KIT
17 glomangiomatosis 10.2 MLANA KIT
18 colon leiomyosarcoma 10.2 KIT APOLD1
19 uterus leiomyosarcoma 10.2 MLANA KIT
20 adult mesoblastic nephroma 10.2 MLANA KIT
21 congenital mesoblastic nephroma 10.2 NRAS KIT
22 ovarian squamous cell carcinoma 10.2 KIT APOLD1
23 kidney benign neoplasm 10.2 MLANA KIT
24 colon sarcoma 10.2 KIT APOLD1
25 perivascular epithelioid cell tumor 10.2 MLANA KIT
26 meckel diverticulum 10.2 KIT APOLD1
27 hypomelanosis of ito 10.1 KIT GNAQ
28 meningeal melanocytoma 10.1 MLANA GNAQ
29 epithelioid cell melanoma 10.1 MLANA GNAQ
30 melanotic neurilemmoma 10.1 MLANA GNAQ
31 mongolian spot 10.1 MLANA GNAQ
32 mesenchymal cell neoplasm 10.1 MLANA KIT
33 cardiovascular cancer 10.1 MLANA KIT
34 mixed cell uveal melanoma 10.1 MLANA GNAQ
35 vascular cancer 10.1 MLANA KIT
36 spermatocytoma 10.1 MAGEC1 KIT
37 lipomatosis, multiple 10.0 MLANA KIT
38 thymoma, familial 10.0 KIT HRAS
39 acneiform dermatitis 9.9 NRAS HRAS
40 schimmelpenning-feuerstein-mims syndrome 9.9 NRAS HRAS
41 acral lentiginous melanoma 9.9 NRAS KIT GNAQ
42 ocular melanoma 9.9 NRAS KIT GNAQ
43 benign struma ovarii 9.9 NRAS HRAS
44 uterine body mixed cancer 9.9 KIT HRAS
45 malignant leptomeningeal tumor 9.9 NRAS MLANA GNAQ
46 meningeal melanoma 9.9 NRAS MLANA GNAQ
47 meningeal melanomatosis 9.9 NRAS MLANA GNAQ
48 melanomatosis 9.9 NRAS MLANA GNAQ
49 melanocytic nevus syndrome, congenital 9.9 NRAS HRAS
50 conjunctival nevus 9.9 NRAS MLANA GNAQ

Graphical network of the top 20 diseases related to Malignant Anus Melanoma:



Diseases related to Malignant Anus Melanoma

Symptoms & Phenotypes for Malignant Anus Melanoma

MGI Mouse Phenotypes related to Malignant Anus Melanoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.92 GNAQ KIT MLANA NRAS

Drugs & Therapeutics for Malignant Anus Melanoma

Search Clinical Trials , NIH Clinical Center for Malignant Anus Melanoma

Genetic Tests for Malignant Anus Melanoma

Anatomical Context for Malignant Anus Melanoma

MalaCards organs/tissues related to Malignant Anus Melanoma:

40
Colon, Skin, Bone, Thyroid, Lymph Node, Bone Marrow, Liver

Publications for Malignant Anus Melanoma

Articles related to Malignant Anus Melanoma:

(show top 50) (show all 52)
# Title Authors PMID Year
1
Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma. 61
30982929 2020
2
Anal melanoma, a radical distinct pathology to the cutaneous melanoma, with an infaustic forecast. 61
31898949 2019
3
Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis. 61
30209727 2018
4
Anal melanoma: Outcomes of current surgical approaches. 61
30560827 2018
5
An interesting case of anal melanoma caused liver metastases due to misdiagnosed as hemorrhoids. 61
30260788 2018
6
Resection for anal melanoma: Is there an optimal approach? 61
30041967 2018
7
Successful Restoration of Fecal Continence Using Sacral Nerve Stimulation Following Chemoradiation and Transanal Excision of an Anal Melanoma With Partial Internal Anal Sphincter Resection: A Case Report. 61
28150422 2017
8
Anal Melanoma in an Elderly Woman Masquerading as Hemorrhoid. 61
29387509 2017
9
SYNCHRONOUS ANAL MELANOMA AND COLON ADENOCARCINOMA: CASE REPORT AND REVIEW OF DIAGNOSIS AND MANAGEMENT. 61
28076491 2016
10
Polypoid anal melanoma. A case report and review of the literature. 61
27857005 2016
11
A case series of anal melanoma including the results of treatment with imatinib in selected patients. 61
26546509 2016
12
Incidence, Surgical Treatment, and Prognosis of Anorectal Melanoma From 1973 to 2011: A Population-Based SEER Analysis. 61
26886623 2016
13
Anal melanoma with neuroendocrine differentiation: report of a case. 61
25722317 2015
14
Anorectal Melanoma: A Case Report and an Update of a Rare Malignancy. 61
29147422 2015
15
Malignant melanoma of anorectal region: a clinicopathologic study of 61 cases. 61
25163722 2014
16
Anal melanoma: a rare and aggressive malignancy. 61
24987890 2014
17
Surgical and radiation therapy management of recurrent anal melanoma. 61
24490051 2014
18
Malignant melanoma of the rectum. 61
24678436 2014
19
Metastatic mucosal melanoma: imaging patterns of metastasis and recurrence. 61
24434078 2013
20
Incidence and survival patterns of rare anal canal neoplasms using the surveillance epidemiology and end results registry. 61
24160801 2013
21
[Melanoma of the anal margin]. 61
23773742 2013
22
Adequate margins for anorectal cancer can be achieved by single-site laparoscopy. 61
23414124 2013
23
Anal versus rectal melanoma: does site of origin predict outcome? 61
23303142 2013
24
Anal melanoma with satellite implantations on the lower rectum. 61
21341945 2011
25
Malignant melanoma of the anorectum--a rare entity. 61
20066546 2010
26
[Melanoma adrenal metastasis: report of 3 cases and literature review]. 61
20646432 2010
27
Long-term outcomes after local excision and radical surgery for anal melanoma: data from a population database. 61
20305438 2010
28
Haemorrhoids or anal melanoma, importance of preoperative histopathological examination: a case report. 61
20496274 2010
29
Laparoscopic abdominoperineal resection for anorectal melanoma: a case report and review of the literature. 61
19692869 2009
30
Melanoma of the anorectal region: the experience of the National Cancer Institute of Milano. 61
18602790 2009
31
[Anal malignant melanoma. Case report and literature review]. 61
19666318 2009
32
Melanoma with cartilaginous differentiation: Diagnostic challenge on fine-needle aspiration with emphasis on differential diagnosis. 61
18973120 2009
33
Local control and distant metastasis after electrochemotherapy of a canine anal melanoma. 61
18019432 2007
34
Multiple bilateral choroidal metastasis from anal melanoma. 61
17701012 2007
35
Melanoma of the anal canal: a case series. 61
17468984 2007
36
Sentinel lymph node biopsy for the staging of anal melanoma: report of two cases. 61
17294674 2006
37
Factors affecting survival in patients with anal melanoma. 61
17058735 2006
38
Anal melanoma. 61
20011314 2006
39
Contemporary indications for and early outcomes of abdominoperineal resection. 61
16468531 2005
40
Anal melanoma in the era of sentinel lymph node mapping: a diagnostic and therapeutic challenge. 61
15868503 2005
41
Sentinel lymph node metastasis in anal melanoma: a case report. 61
12630771 2002
42
Malignant melanoma metastatic to bone marrow. 61
12593576 2002
43
Anal carcinoma or "just hemorrhoids"? 61
11730221 2001
44
Anal melanoma: an aggressive malignancy masquerading as hemorrhoids. 61
11592745 2001
45
Primary anal melanoma associated with melanosis of the upper gastrointestinal tract. 61
9826150 1998
46
Early experience with laparoscopic abdominoperineal resection. 61
9153173 1997
47
Rare anal canal cancers in the U.S. veteran: patterns of disease and results of treatment. 61
7762897 1995
48
[Cancer of the anus: incidence and behavior of melanoma in our series]. 61
2390342 1990
49
Anal melanoma. A case report. 61
2628395 1989
50
Anal melanoma: case report and review. 61
3489890 1986

Variations for Malignant Anus Melanoma

Expression for Malignant Anus Melanoma

Search GEO for disease gene expression data for Malignant Anus Melanoma.

Pathways for Malignant Anus Melanoma

Pathways related to Malignant Anus Melanoma according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 NRAS KIT HRAS GNAQ
2 12.57 NRAS KIT HRAS GNAQ
3
Show member pathways
12.47 NRAS KIT HRAS GNAQ
4
Show member pathways
12.44 NRAS KIT HRAS GNAQ
5
Show member pathways
12.42 NRAS HRAS GNAQ
6
Show member pathways
12.26 NRAS HRAS GNAQ
7
Show member pathways
12.19 NRAS KIT HRAS
8
Show member pathways
11.95 NRAS HRAS GNAQ
9 11.84 NRAS HRAS GNAQ
10
Show member pathways
11.81 NRAS HRAS GNAQ
11 11.73 NRAS HRAS GNAQ
12 11.69 NRAS HRAS GNAQ
13 11.66 NRAS HRAS GNAQ
14 11.51 NRAS HRAS GNAQ
15 11.49 NRAS HRAS GNAQ
16
Show member pathways
11.42 NRAS KIT HRAS
17 11.32 NRAS HRAS
18 11.27 NRAS HRAS
19 11.27 NRAS KIT HRAS
20 11.21 NRAS HRAS
21 11.14 NRAS HRAS
22 11.14 NRAS HRAS GNAQ
23 11.09 NRAS HRAS
24 11.08 NRAS HRAS
25
Show member pathways
11.06 NRAS HRAS
26
Show member pathways
11.01 NRAS HRAS
27 10.95 NRAS HRAS
28 10.92 NRAS HRAS
29 10.91 NRAS HRAS GNAQ
30 10.62 NRAS HRAS
31 10.1 NRAS HRAS GNAQ

GO Terms for Malignant Anus Melanoma

Biological processes related to Malignant Anus Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.13 NRAS KIT HRAS
2 positive regulation of phospholipase C activity GO:0010863 8.62 KIT HRAS

Molecular functions related to Malignant Anus Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase activity GO:0003924 8.8 NRAS HRAS GNAQ

Sources for Malignant Anus Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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