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MCID: MLG038
MIFTS: 30

Malignant Anus Melanoma

Categories: Cancer diseases, Gastrointestinal diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Malignant Anus Melanoma

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MalaCards integrated aliases for Malignant Anus Melanoma:

Name: Malignant Anus Melanoma 12 15
Malignant Melanoma of Anus 12 71
Anal Melanoma 12 17

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:14145
NCIt 50 C4639
SNOMED-CT 67 276821000
UMLS 71 C0349538
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Summaries for Malignant Anus Melanoma

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MalaCards based summary : Malignant Anus Melanoma, also known as malignant melanoma of anus, is related to amelanotic melanoma and skin melanoma. An important gene associated with Malignant Anus Melanoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Activation of cAMP-Dependent PKA and TGF-Beta Pathway. Affiliated tissues include lymph node, bone marrow and colon, and related phenotypes are no phenotypic analysis and pigmentation

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Related Diseases for Malignant Anus Melanoma

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Diseases related to Malignant Anus Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 amelanotic melanoma 30.0 MLANA KIT
2 skin melanoma 28.6 NRAS MLANA KIT IL2 HRAS GNA11
3 mucosal melanoma 28.5 NRAS MAGEC2 MAGEC1 KIT IL2 GNA11
4 melanoma 28.4 NRAS MLANA MAGEC2 MAGEC1 KIT IL2
5 benign perivascular tumor 10.2 MLANA KIT
6 small intestine leiomyoma 10.2 MLANA KIT
7 skin sarcoma 10.2 MLANA KIT
8 melanomatosis 10.2 NRAS MLANA
9 retroperitoneal sarcoma 10.2 MLANA KIT
10 mucinous stomach adenocarcinoma 10.2 MLANA KIT
11 glomangiomatosis 10.2 MLANA KIT
12 vagina sarcoma 10.2 MLANA KIT
13 thymus clear cell carcinoma 10.2 MLANA KIT
14 uterus leiomyosarcoma 10.2 MLANA KIT
15 uterine corpus sarcoma 10.2 MLANA KIT
16 ovarian melanoma 10.2 NRAS MLANA
17 sensory organ benign neoplasm 10.2 NRAS MLANA
18 retroperitoneum carcinoma 10.2 MLANA KIT
19 bladder sarcoma 10.2 MLANA KIT
20 kidney benign neoplasm 10.2 MLANA KIT
21 perivascular epithelioid cell tumor 10.2 MLANA KIT
22 orbit rhabdomyosarcoma 10.2 NRAS MLANA
23 meningeal melanocytoma 10.1 MLANA GNA11
24 hemorrhoid 10.1
25 epithelioid cell melanoma 10.1 MLANA GNA11
26 mesenchymal cell neoplasm 10.1 MLANA KIT
27 mongolian spot 10.1 MLANA GNA11
28 acneiform dermatitis 10.1 NRAS HRAS
29 connective tissue benign neoplasm 10.1 MLANA KIT
30 nasal cavity adenocarcinoma 10.1 MLANA HRAS
31 lipomatosis, multiple 10.1 MLANA KIT
32 hypomelanosis of ito 10.1 NRAS GNA11
33 nasal cavity cancer 10.1 MLANA HRAS
34 oculoectodermal syndrome 10.1 NRAS HRAS
35 large intestine adenocarcinoma 10.1 NRAS HRAS
36 uterine body mixed cancer 10.1 KIT HRAS
37 melanocytic nevus syndrome, congenital 10.1 NRAS HRAS
38 benign struma ovarii 10.1 NRAS HRAS
39 mixed cell type cancer 10.1 KIT HRAS
40 respiratory system benign neoplasm 10.0 MLANA HRAS
41 lip and oral cavity cancer 10.0 KIT HRAS
42 ras-associated autoimmune leukoproliferative disorder 10.0 NRAS HRAS
43 schimmelpenning-feuerstein-mims syndrome 10.0 NRAS HRAS
44 well-differentiated liposarcoma 10.0 MLANA KIT
45 gallbladder melanoma 10.0 MLANA IL2
46 thyroid cancer, nonmedullary, 2 10.0 NRAS HRAS
47 melphalan allergy 10.0 NRAS IL2
48 muscle cancer 9.9 MLANA KIT HRAS
49 core binding factor acute myeloid leukemia 9.9 NRAS KIT HRAS
50 vulvar disease 9.9 NRAS KIT HRAS

Graphical network of the top 20 diseases related to Malignant Anus Melanoma:



Diseases related to Malignant Anus Melanoma
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Symptoms & Phenotypes for Malignant Anus Melanoma

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MGI Mouse Phenotypes related to Malignant Anus Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.35 HRAS IL2 KIT MLANA NRAS
2 pigmentation MP:0001186 8.92 GNA11 KIT MLANA NRAS
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Drugs & Therapeutics for Malignant Anus Melanoma

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Search Clinical Trials , NIH Clinical Center for Malignant Anus Melanoma

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Genetic Tests for Malignant Anus Melanoma

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Anatomical Context for Malignant Anus Melanoma

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MalaCards organs/tissues related to Malignant Anus Melanoma:

40
Lymph Node, Bone Marrow, Colon
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Publications for Malignant Anus Melanoma

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Articles related to Malignant Anus Melanoma:

(show top 50) (show all 58)
# Title Authors PMID Year
1
Safety and efficacy of electrochemotherapy in a series of patients with nonmetastasized primary or recurrent anorectal malignant melanoma. 61
33038094 2021
2
An observational study of the demographic and treatment changes in a tertiary colorectal cancer center during the COVID-19 pandemic. 61
32885429 2020
3
Epidemiology and survival outcomes of primary gastrointestinal melanoma: a SEER-based population study. 61
32740718 2020
4
Anal melanoma, a radically different pathology from cutaneous melanoma with a tragic prognosis. 61
31898949 2020
5
Anal Melanoma: A Rare Perianal Tumor With a Poor Prognosis. 61
32271217 2020
6
Expert Commentary on Anal Melanoma: A Rare Perianal Tumor With a Poor Prognosis. 61
32271218 2020
7
Early primary anorectal malignant melanoma treated with endoscopic submucosal dissection: a case report. 61
32124048 2020
8
Resectable Anal Melanoma Detected by Rectal Retroflexion. 61
32272246 2020
9
Patterns of Care and Survival Outcomes in the Treatment of Anal Melanoma. 61
30982929 2020
10
Anal melanoma: Outcomes of current surgical approaches. 61
30560827 2018
11
Contemporary Surgical Management and Outcomes for Anal Melanoma: A National Cancer Database Analysis. 61
30209727 2018
12
An interesting case of anal melanoma caused liver metastases due to misdiagnosed as hemorrhoids. 61
30260788 2018
13
Resection for anal melanoma: Is there an optimal approach? 61
30041967 2018
14
Successful Restoration of Fecal Continence Using Sacral Nerve Stimulation Following Chemoradiation and Transanal Excision of an Anal Melanoma With Partial Internal Anal Sphincter Resection: A Case Report. 61
28150422 2017
15
Anal Melanoma in an Elderly Woman Masquerading as Hemorrhoid. 61
29387509 2017
16
SYNCHRONOUS ANAL MELANOMA AND COLON ADENOCARCINOMA: CASE REPORT AND REVIEW OF DIAGNOSIS AND MANAGEMENT. 61
28076491 2016
17
Polypoid anal melanoma. A case report and review of the literature. 61
27857005 2016
18
A case series of anal melanoma including the results of treatment with imatinib in selected patients. 61
26546509 2016
19
Incidence, Surgical Treatment, and Prognosis of Anorectal Melanoma From 1973 to 2011: A Population-Based SEER Analysis. 61
26886623 2016
20
Anal melanoma with neuroendocrine differentiation: report of a case. 61
25722317 2015
21
Anorectal Melanoma: A Case Report and an Update of a Rare Malignancy. 61
29147422 2015
22
Malignant melanoma of anorectal region: a clinicopathologic study of 61 cases. 61
25163722 2014
23
Anal melanoma: a rare and aggressive malignancy. 61
24987890 2014
24
Surgical and radiation therapy management of recurrent anal melanoma. 61
24490051 2014
25
Malignant melanoma of the rectum. 61
24678436 2014
26
Metastatic mucosal melanoma: imaging patterns of metastasis and recurrence. 61
24434078 2013
27
Incidence and survival patterns of rare anal canal neoplasms using the surveillance epidemiology and end results registry. 61
24160801 2013
28
[Melanoma of the anal margin]. 61
23773742 2013
29
Adequate margins for anorectal cancer can be achieved by single-site laparoscopy. 61
23414124 2013
30
Anal versus rectal melanoma: does site of origin predict outcome? 61
23303142 2013
31
Anal melanoma with satellite implantations on the lower rectum. 61
21341945 2011
32
Malignant melanoma of the anorectum--a rare entity. 61
20066546 2010
33
Long-term outcomes after local excision and radical surgery for anal melanoma: data from a population database. 61
20305438 2010
34
[Melanoma adrenal metastasis: report of 3 cases and literature review]. 61
20646432 2010
35
Haemorrhoids or anal melanoma, importance of preoperative histopathological examination: a case report. 61
20496274 2010
36
Laparoscopic abdominoperineal resection for anorectal melanoma: a case report and review of the literature. 61
19692869 2009
37
Melanoma of the anorectal region: the experience of the National Cancer Institute of Milano. 61
18602790 2009
38
[Anal malignant melanoma. Case report and literature review]. 61
19666318 2009
39
Melanoma with cartilaginous differentiation: Diagnostic challenge on fine-needle aspiration with emphasis on differential diagnosis. 61
18973120 2009
40
Local control and distant metastasis after electrochemotherapy of a canine anal melanoma. 61
18019432 2007
41
Multiple bilateral choroidal metastasis from anal melanoma. 61
17701012 2007
42
Melanoma of the anal canal: a case series. 61
17468984 2007
43
Sentinel lymph node biopsy for the staging of anal melanoma: report of two cases. 61
17294674 2006
44
Factors affecting survival in patients with anal melanoma. 61
17058735 2006
45
Anal melanoma. 61
20011314 2006
46
Contemporary indications for and early outcomes of abdominoperineal resection. 61
16468531 2005
47
Anal melanoma in the era of sentinel lymph node mapping: a diagnostic and therapeutic challenge. 61
15868503 2005
48
Sentinel lymph node metastasis in anal melanoma: a case report. 61
12630771 2002
49
Malignant melanoma metastatic to bone marrow. 61
12593576 2002
50
Anal carcinoma or "just hemorrhoids"? 61
11730221 2001
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Variations for Malignant Anus Melanoma

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Expression for Malignant Anus Melanoma

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Search GEO for disease gene expression data for Malignant Anus Melanoma.
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Pathways for Malignant Anus Melanoma

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Pathways related to Malignant Anus Melanoma according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Activation of cAMP-Dependent PKA 63
Show member pathways
 13.31 NRAS KIT IL2 HRAS GNA11
2
TGF-Beta Pathway 63
Show member pathways
 13.29 NRAS KIT IL2 HRAS GNA11
3
Akt Signaling 63
Show member pathways
 13.14 NRAS KIT IL2 HRAS GNA11
4
CREB Pathway 63
Show member pathways
 13.02 NRAS KIT IL2 HRAS GNA11
5
Toll-like Receptor Signaling Pathway 36 1
Show member pathways
 12.84 NRAS IL2 HRAS GNA11
6
PI3K-Akt signaling pathway 36
Show member pathways
 12.75 NRAS KIT IL2 HRAS
7
Phospholipase-C Pathway 63
Show member pathways
 12.7 NRAS KIT IL2 HRAS GNA11
8
Aldosterone synthesis and secretion 36
Show member pathways
 12.64 NRAS KIT HRAS GNA11
9
p70S6K Signaling 63
Show member pathways
 12.6 NRAS KIT IL2 HRAS GNA11
10
Development Angiotensin activation of ERK 23
Show member pathways
 12.56 NRAS KIT HRAS GNA11
11
Development Endothelin-1/EDNRA signaling 23
Show member pathways
 12.44 NRAS HRAS GNA11
12
Immune response IL-23 signaling pathway 23
Show member pathways
 12.39 NRAS IL2 HRAS
13
NF-kappaB Signaling 4
12.37 MLANA KIT IL2
14
Immune response Role of DAP12 receptors in NK cells 23
Show member pathways
 12.32 NRAS IL2 HRAS
15
Oxytocin signaling pathway 36
Show member pathways
 12.3 NRAS HRAS GNA11
16
Apoptosis Pathway 70
Show member pathways
 12.25 NRAS IL2 HRAS
17
Phospholipase D signaling pathway 36
Show member pathways
 12.2 NRAS KIT HRAS
18
Human T-cell leukemia virus 1 infection 36
12.13 NRAS IL2 HRAS
19
G-protein signaling RAC1 in cellular process 23
Show member pathways
 12.12 NRAS KIT IL2 HRAS
20
C-type lectin receptor signaling pathway 36
Show member pathways
 11.97 NRAS IL2 HRAS
21
UVA-Induced MAPK Signaling 63
Show member pathways
 11.83 NRAS HRAS GNA11
22
Pathways in cancer 36
11.75 NRAS KIT IL2 HRAS GNA11
23
Gap junction 36
11.6 NRAS HRAS GNA11
24
VEGF Pathway (Tocris) 60
Show member pathways
 11.55 NRAS KIT HRAS
25
G-protein signaling_RhoA regulation pathway 23
11.42 NRAS IL2 HRAS GNA11
26
Commom Cytokine Receptor G Chain Siganaling Pathway 66
11.4 NRAS IL2 HRAS
27
Aryl Hydrocarbon Receptor 1
11.36 NRAS HRAS
28
Vemurafenib Pathway, Pharmacodynamics 60
11.3 NRAS HRAS
29
Central carbon metabolism in cancer 36
11.28 NRAS KIT HRAS
30
Crizotinib Pathway, Pharmacokinetics/Pharmacodynamics 60
11.23 NRAS HRAS
31
BDNF-TrkB Signaling 1
11.16 NRAS HRAS
32
GnRH secretion 36
11.14 NRAS HRAS GNA11
33
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
11.11 NRAS HRAS
34
Extracellular vesicle-mediated signaling in recipient cells 1
11.1 NRAS HRAS
35
Bisphosphonate Pathway, Pharmacodynamics 60
Show member pathways
 11.09 NRAS HRAS
36
EGFR Transactivation by Gastrin 65
Show member pathways
 11.02 NRAS HRAS
37
MNAR-PELP1 and Estrogen Receptor Interaction 63
10.96 NRAS HRAS
38
CD209 (DC-SIGN) signaling 65
10.93 NRAS HRAS
39
Long-term depression 36
10.91 NRAS HRAS GNA11
40
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling 1
10.88 NRAS HRAS
41
p38MAPK events 65
10.62 NRAS HRAS
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GO Terms for Malignant Anus Melanoma

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Biological processes related to Malignant Anus Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell differentiation GO:0030217 9.26 KIT IL2
2 positive regulation of phospholipase C activity GO:0010863 9.16 KIT HRAS
3 developmental pigmentation GO:0048066 8.96 KIT GNA11
4 MAPK cascade GO:0000165 8.92 NRAS KIT IL2 HRAS

Molecular functions related to Malignant Anus Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTPase activity GO:0003924 8.8 NRAS HRAS GNA11
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Sources for Malignant Anus Melanoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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