MCID: MLG011
MIFTS: 28

Malignant Biphasic Mesothelioma

Categories: Cancer diseases

Aliases & Classifications for Malignant Biphasic Mesothelioma

MalaCards integrated aliases for Malignant Biphasic Mesothelioma:

Name: Malignant Biphasic Mesothelioma 12 15
Mesothelioma, Biphasic, Malignant 12 73
Mixed Mesothelioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4486
NCIt 50 C4282
SNOMED-CT 68 30383009
UMLS 73 C0334515

Summaries for Malignant Biphasic Mesothelioma

MalaCards based summary : Malignant Biphasic Mesothelioma, also known as mesothelioma, biphasic, malignant, is related to malignant pleural mesothelioma and malignant epithelial mesothelioma. An important gene associated with Malignant Biphasic Mesothelioma is THBD (Thrombomodulin), and among its related pathways/superpathways are Cytoskeletal Signaling and Cell surface interactions at the vascular wall. The drugs Pembrolizumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include liver.

Related Diseases for Malignant Biphasic Mesothelioma

Diseases related to Malignant Biphasic Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 161)
# Related Disease Score Top Affiliating Genes
1 malignant pleural mesothelioma 30.1 CALB2 MSLN THBD WT1
2 malignant epithelial mesothelioma 10.9 THBD WT1
3 fallopian tube carcinosarcoma 10.9 CALB2 WT1
4 sarcomatoid mesothelioma 10.8 THBD WT1
5 spindle cell liposarcoma 10.7 CALB2 WT1
6 peritoneum cancer 10.7 KRT5 WT1
7 sertoli cell tumor 10.7 CALB2 WT1
8 pneumatosis cystoides intestinalis 10.7 CALB2 WT1
9 endosalpingiosis 10.7 KRT7 WT1
10 renal adenoma 10.7 KRT7 WT1
11 female reproductive endometrioid cancer 10.7 KRT7 WT1
12 epidermolysis bullosa simplex with mottled pigmentation 10.6 KRT10 KRT5
13 epithelial predominant wilms' tumor 10.6 KRT7 WT1
14 breast squamous cell carcinoma 10.6 KRT10 KRT5
15 gastric squamous cell carcinoma 10.6 KRT10 KRT5
16 inverted transitional papilloma 10.6 KRT5 KRT7
17 balloon cell malignant melanoma 10.6 KRT5 KRT7
18 benign breast adenomyoepithelioma 10.6 KRT5 KRT7
19 mucinous bronchioloalveolar adenocarcinoma 10.6 CALB2 KRT7
20 metanephric adenoma 10.6 KRT7 WT1
21 sensory organ benign neoplasm 10.6 KRT5 KRT7
22 malignant leydig cell tumor 10.6 CALB2 KRT7
23 epidermolysis bullosa simplex, dowling-meara type 10.6 KRT10 KRT5
24 middle ear adenoma 10.6 KRT5 KRT7
25 papillary adenoma 10.6 KRT5 KRT7
26 apocrine sweat gland neoplasm 10.6 KRT5 KRT7
27 apocrine adenocarcinoma 10.6 KRT5 KRT7
28 cervix endometriosis 10.5 CALB2 CEACAM5
29 esophageal adenosquamous carcinoma 10.5 CEACAM5 KRT5
30 clear cell adenofibroma 10.5 CALB2 KRT7
31 bowen's disease 10.5 KRT10 KRT7
32 nephrotic syndrome, type 1 10.5 AFP WT1
33 peritoneal mesothelioma 10.5 THBD WT1
34 atypical choroid plexus papilloma 10.5 KRT5 KRT7
35 lymphoepithelioma-like carcinoma 10.5 KRT5 KRT7
36 lung sarcoma 10.5 CALB2 KRT5 THBD
37 lipoadenoma 10.5 KRT5 KRT7
38 nasal cavity squamous cell carcinoma 10.5 KRT5 KRT7
39 mixed cell type cancer 10.5 KRT5 KRT7
40 cervical clear cell adenocarcinoma 10.4 CEACAM5 KRT5
41 spermatocele 10.4 CALB2 CEACAM5
42 intrahepatic bile duct adenoma 10.4 AFP KRT7
43 cutaneous mucoepidermoid carcinoma 10.4 CEACAM5 KRT7
44 anal gland adenocarcinoma 10.4 CEACAM5 KRT7
45 mucinous adenofibroma 10.4 CEACAM5 KRT7
46 anus adenocarcinoma 10.4 CEACAM5 KRT7
47 necrotizing sialometaplasia 10.4 KRT5 KRT7
48 renal pelvis adenocarcinoma 10.4 AFP KRT7
49 ovarian germ cell cancer 10.4 AFP KRT7
50 cutaneous adenocystic carcinoma 10.4 CEACAM5 KRT7

Graphical network of the top 20 diseases related to Malignant Biphasic Mesothelioma:



Diseases related to Malignant Biphasic Mesothelioma

Symptoms & Phenotypes for Malignant Biphasic Mesothelioma

Drugs & Therapeutics for Malignant Biphasic Mesothelioma

Drugs for Malignant Biphasic Mesothelioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2 Antibodies Phase 2,Phase 1
3 Immunoglobulins Phase 2,Phase 1
4 Tin Fluorides Phase 2
5
Cisplatin Approved Phase 1 15663-27-1 84093 441203 2767
6
Pemetrexed Approved, Investigational Phase 1 150399-23-8, 137281-23-3 446556 60843
7
leucovorin Approved, Nutraceutical Phase 1 58-05-9 143 6006
8
Glutamic Acid Approved, Nutraceutical Phase 1 56-86-0 33032
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
10 Folic Acid Antagonists Phase 1
11 Nucleic Acid Synthesis Inhibitors Phase 1
12 Vitamin B Complex Phase 1
13 Antibodies, Monoclonal Phase 1
14 Folate Nutraceutical Phase 1
15 Vitamin B9 Nutraceutical Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pembrolizumab in Treating Patients With Malignant Mesothelioma Active, not recruiting NCT02399371 Phase 2
2 Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma Recruiting NCT03228537 Phase 1 Atezolizumab;Cisplatin;Pemetrexed Disodium

Search NIH Clinical Center for Malignant Biphasic Mesothelioma

Genetic Tests for Malignant Biphasic Mesothelioma

Anatomical Context for Malignant Biphasic Mesothelioma

MalaCards organs/tissues related to Malignant Biphasic Mesothelioma:

41
Liver

Publications for Malignant Biphasic Mesothelioma

Articles related to Malignant Biphasic Mesothelioma:

# Title Authors Year
1
Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis. ( 19195066 )
2009
2
Case of malignant biphasic mesothelioma in a dog. ( 11765328 )
2001

Variations for Malignant Biphasic Mesothelioma

Expression for Malignant Biphasic Mesothelioma

Search GEO for disease gene expression data for Malignant Biphasic Mesothelioma.

Pathways for Malignant Biphasic Mesothelioma

Pathways related to Malignant Biphasic Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.75 EPCAM KRT10 KRT5 KRT7
2
Show member pathways
11.69 CEACAM5 EPCAM THBD
3 11.42 CEACAM5 EPCAM MSLN
4 11.05 AFP EPCAM MYC WT1

GO Terms for Malignant Biphasic Mesothelioma

Cellular components related to Malignant Biphasic Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.26 EPCAM FUT4 MSLN THBD
2 intermediate filament GO:0005882 8.8 KRT10 KRT5 KRT7

Biological processes related to Malignant Biphasic Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.33 CEACAM5 EPCAM THBD
2 keratinization GO:0031424 9.13 KRT10 KRT5 KRT7
3 cornification GO:0070268 8.8 KRT10 KRT5 KRT7

Sources for Malignant Biphasic Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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