MCID: MLG011
MIFTS: 26

Malignant Biphasic Mesothelioma

Categories: Cancer diseases

Aliases & Classifications for Malignant Biphasic Mesothelioma

MalaCards integrated aliases for Malignant Biphasic Mesothelioma:

Name: Malignant Biphasic Mesothelioma 12 15
Mesothelioma, Biphasic, Malignant 12 73
Mixed Mesothelioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4486
NCIt 50 C4282
SNOMED-CT 68 30383009
UMLS 73 C0334515

Summaries for Malignant Biphasic Mesothelioma

MalaCards based summary : Malignant Biphasic Mesothelioma, also known as mesothelioma, biphasic, malignant, is related to malignant pleural mesothelioma and mesothelioma, malignant. An important gene associated with Malignant Biphasic Mesothelioma is WT1 (Wilms Tumor 1), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Cytoskeletal Signaling. The drugs Pembrolizumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include liver, kidney and colon.

Related Diseases for Malignant Biphasic Mesothelioma

Diseases related to Malignant Biphasic Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 140)
# Related Disease Score Top Affiliating Genes
1 malignant pleural mesothelioma 30.0 CALB2 MSLN THBD WT1
2 mesothelioma, malignant 29.5 CALB2 CEACAM5 KRT7 MSLN THBD WT1
3 malignant epithelial mesothelioma 10.3 THBD WT1
4 fallopian tube carcinosarcoma 10.3 CALB2 WT1
5 sarcomatoid mesothelioma 10.2 THBD WT1
6 peritoneal benign neoplasm 10.2 CALB2 WT1
7 diffuse peritoneal leiomyomatosis 10.2 CALB2 WT1
8 venous hemangioma 10.2 CALB2 WT1
9 mixed germ cell-sex cord neoplasm 10.2 CALB2 WT1
10 spindle cell liposarcoma 10.2 CALB2 WT1
11 sertoli cell tumor 10.2 CALB2 WT1
12 peritoneal mesothelioma 10.2 THBD WT1
13 pneumatosis cystoides intestinalis 10.2 CALB2 WT1
14 endosalpingiosis 10.2 KRT7 WT1
15 breast squamous cell carcinoma 10.2 KRT10 KRT5
16 renal adenoma 10.2 KRT7 WT1
17 epithelial predominant wilms' tumor 10.2 KRT7 WT1
18 epidermolysis bullosa simplex with mottled pigmentation 10.2 KRT10 KRT5
19 dysgerminoma of ovary 10.2 CALB2 WT1
20 female reproductive endometrioid cancer 10.2 KRT7 WT1
21 metanephric adenoma 10.2 KRT7 WT1
22 lymphoepithelioma-like thymic carcinoma 10.2 EPCAM KRT5
23 cervix endometriosis 10.2 CALB2 CEACAM5
24 kidney benign neoplasm 10.2 KRT7 WT1
25 inverted transitional papilloma 10.1 KRT5 KRT7
26 balloon cell malignant melanoma 10.1 KRT5 KRT7
27 malignant leydig cell tumor 10.1 CALB2 KRT7
28 benign breast adenomyoepithelioma 10.1 KRT5 KRT7
29 epidermolysis bullosa simplex, dowling-meara type 10.1 KRT10 KRT5
30 malignant acrospiroma 10.1 CEACAM5 KRT5
31 adenosquamous carcinoma 10.1 KRT5 KRT7
32 esophageal adenosquamous carcinoma 10.1 CEACAM5 KRT5
33 ceruminoma 10.1 KRT5 KRT7
34 sensory organ benign neoplasm 10.1 KRT5 KRT7
35 middle ear adenoma 10.1 KRT5 KRT7
36 apocrine sweat gland neoplasm 10.1 KRT5 KRT7
37 prostatic acinar adenocarcinoma 10.1 KRT7 WT1
38 clear cell adenofibroma 10.1 CALB2 KRT7
39 mucinous bronchioloalveolar adenocarcinoma 10.1 CALB2 KRT7
40 bowen's disease 10.1 KRT10 KRT7
41 lymphoepithelioma-like carcinoma 10.1 KRT5 KRT7
42 lipoadenoma 10.1 KRT5 KRT7
43 nasal cavity squamous cell carcinoma 10.1 KRT5 KRT7
44 atypical choroid plexus papilloma 10.1 KRT5 KRT7
45 nephrogenic adenofibroma 10.1 KRT7 WT1
46 breast secretory carcinoma 10.1 KRT5 KRT7
47 horseshoe kidney 10.1 CALB2 KRT7
48 pregnancy adenoma 10.1 KRT5 KRT7
49 necrotizing sialometaplasia 10.1 KRT5 KRT7
50 mixed ductal-endocrine carcinoma 10.1 CALB2 CEACAM5

Graphical network of the top 20 diseases related to Malignant Biphasic Mesothelioma:



Diseases related to Malignant Biphasic Mesothelioma

Symptoms & Phenotypes for Malignant Biphasic Mesothelioma

Drugs & Therapeutics for Malignant Biphasic Mesothelioma

Drugs for Malignant Biphasic Mesothelioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2 Antibodies Phase 2,Phase 1
3 Immunoglobulins Phase 2,Phase 1
4 Tin Fluorides Phase 2
5
leucovorin Approved Phase 1 58-05-9 6006 143
6
Pemetrexed Approved, Investigational Phase 1 150399-23-8, 137281-23-3 446556 60843
7
Atezolizumab Approved, Investigational Phase 1 1380723-44-3
8
Cisplatin Approved Phase 1 15663-27-1 2767 441203 84093
9
Glutamic Acid Approved, Nutraceutical Phase 1 56-86-0 33032
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
11 Immunologic Factors Phase 1
12 Vitamin B9 Phase 1
13 Vitamin B Complex Phase 1
14 Nucleic Acid Synthesis Inhibitors Phase 1
15 Folic Acid Antagonists Phase 1
16 Antibodies, Monoclonal Phase 1
17 Folate Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pembrolizumab in Treating Patients With Malignant Mesothelioma Active, not recruiting NCT02399371 Phase 2
2 Atezolizumab, Pemetrexed Disodium, Cisplatin, and Surgery With or Without Radiation Therapy in Treating Patients With Stage I-III Pleural Malignant Mesothelioma Recruiting NCT03228537 Phase 1 Atezolizumab;Cisplatin;Pemetrexed Disodium

Search NIH Clinical Center for Malignant Biphasic Mesothelioma

Genetic Tests for Malignant Biphasic Mesothelioma

Anatomical Context for Malignant Biphasic Mesothelioma

MalaCards organs/tissues related to Malignant Biphasic Mesothelioma:

41
Liver, Kidney, Colon, Ovary, Prostate, Testis, Thymus

Publications for Malignant Biphasic Mesothelioma

Articles related to Malignant Biphasic Mesothelioma:

# Title Authors Year
1
Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis. ( 19195066 )
2009
2
Case of malignant biphasic mesothelioma in a dog. ( 11765328 )
2001

Variations for Malignant Biphasic Mesothelioma

Expression for Malignant Biphasic Mesothelioma

Search GEO for disease gene expression data for Malignant Biphasic Mesothelioma.

Pathways for Malignant Biphasic Mesothelioma

Pathways related to Malignant Biphasic Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.58 CEACAM5 EPCAM THBD
2 11.41 EPCAM KRT10 KRT5 KRT7
3 11.22 CEACAM5 EPCAM MSLN

GO Terms for Malignant Biphasic Mesothelioma

Cellular components related to Malignant Biphasic Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.63 CEACAM5 EPCAM KRT10 KRT5 KRT7 OSCAR
2 intermediate filament GO:0005882 9.13 KRT10 KRT5 KRT7
3 cell surface GO:0009986 9.1 CEACAM5 EPCAM FUT4 MSLN OSCAR THBD

Biological processes related to Malignant Biphasic Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ureteric bud development GO:0001657 9.16 EPCAM WT1
2 keratinization GO:0031424 9.13 KRT10 KRT5 KRT7
3 cornification GO:0070268 8.8 KRT10 KRT5 KRT7

Sources for Malignant Biphasic Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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