MCID: MLG008
MIFTS: 21

Malignant Breast Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Malignant Breast Melanoma

MalaCards integrated aliases for Malignant Breast Melanoma:

Name: Malignant Breast Melanoma 12 15
Malignant Melanoma of Breast 12 71
Breast Melanoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4364
NCIt 49 C8410
UMLS 71 C0346787

Summaries for Malignant Breast Melanoma

Disease Ontology : 12 A breast cancer that arises from melanocytes.

MalaCards based summary : Malignant Breast Melanoma, also known as malignant melanoma of breast, is related to melanoma and retinoblastoma. An important gene associated with Malignant Breast Melanoma is FMNL3 (Formin Like 3), and among its related pathways/superpathways are Signaling by Rho GTPases and Mitotic Prometaphase. The drugs Sunitinib and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include breast, liver and skin.

Related Diseases for Malignant Breast Melanoma

Diseases related to Malignant Breast Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 melanoma 9.9
2 retinoblastoma 9.7
3 familial retinoblastoma 9.7
4 severe combined immunodeficiency 9.7
5 cerebral amyloid angiopathy, itm2b-related, 2 8.5 FMNL3 FMNL2 FMNL1 FHOD1 DAAM2

Graphical network of the top 20 diseases related to Malignant Breast Melanoma:



Diseases related to Malignant Breast Melanoma

Symptoms & Phenotypes for Malignant Breast Melanoma

Drugs & Therapeutics for Malignant Breast Melanoma

Drugs for Malignant Breast Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 4 341031-54-7, 557795-19-4 5329102
2 Protein Kinase Inhibitors Phase 4
3 Angiogenesis Inhibitors Phase 4
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5 Liver Extracts Phase 2
6 Albumin-Bound Paclitaxel Phase 2
7 Antimitotic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Study of Biological, Pathological and Imagery Markers in the First-line Treatment of Metastatic Clear-cell Renal Cell Carcinoma With Sunitinib BEFORE and AFTER Nephrectomy Terminated NCT00930345 Phase 4 Sunitinib (SUTENT)
2 A Phase II Trial: Safety and Tolerance of Intravenous 4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in Patients With Malignancies Involving the Central Nervous System Completed NCT02038218 Phase 2 4-Demethyl-4-cholestryloxycarbonylpenclomedine
3 Phase II Trial of Nab-Paclitaxel as First Line Cytotoxic Chemotherapy in Patients With Unresectable and Metastatic Cutaneous Squamous Cell Carcinoma Terminated NCT02076243 Phase 2 nab-paclitaxel
4 A Phase I Trial to Evaluate Safety and Tolerance of Intravenous 4-Demethyl-4-cholesteryloxycarbonylpenclomedine (DM-CHOC-PEN) in Adult Subjects With Cancer Involving the CNS Recruiting NCT03371004 Phase 1 4-Demethyl-4-cholesteryloxycarbonylpenclomedine
5 Impact of Dietary Intervention on Tumor Immunity: the DigesT Trial. Recruiting NCT03454282
6 Robot-assisted Approach to Cervical Cancer Recruiting NCT03719547

Search NIH Clinical Center for Malignant Breast Melanoma

Genetic Tests for Malignant Breast Melanoma

Anatomical Context for Malignant Breast Melanoma

MalaCards organs/tissues related to Malignant Breast Melanoma:

40
Breast, Liver, Skin

Publications for Malignant Breast Melanoma

Articles related to Malignant Breast Melanoma:

# Title Authors PMID Year
1
Malignant melanoma of breast: a unique case with diagnostic dilemmas. 61
24943768 2014

Variations for Malignant Breast Melanoma

Expression for Malignant Breast Melanoma

Search GEO for disease gene expression data for Malignant Breast Melanoma.

Pathways for Malignant Breast Melanoma

Pathways related to Malignant Breast Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.78 FMNL3 FMNL2 FMNL1 ARHGEF11
2
Show member pathways
11.67 FMNL3 FMNL2 FMNL1

GO Terms for Malignant Breast Melanoma

Cellular components related to Malignant Breast Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.43 FNBP1L FMNL3 FMNL2 FMNL1 FHOD1 ARHGEF11
2 cell cortex GO:0005938 9.16 FNBP1L FMNL1
3 bleb GO:0032059 8.62 FMNL1 FHOD1

Biological processes related to Malignant Breast Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton organization GO:0007010 9.5 FMNL3 FMNL2 FMNL1
2 regulation of cell shape GO:0008360 9.43 FMNL3 FMNL2 FMNL1
3 actin cytoskeleton organization GO:0030036 9.35 FMNL3 FMNL2 FMNL1 DAAM2 ARHGEF11
4 cortical actin cytoskeleton organization GO:0030866 9.33 FMNL3 FMNL2 FMNL1
5 cellular component organization GO:0016043 8.92 FMNL3 FMNL2 FMNL1 DAAM2

Molecular functions related to Malignant Breast Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin binding GO:0003779 9.55 FMNL3 FMNL2 FMNL1 FHOD1 DAAM2
2 GTPase activating protein binding GO:0032794 9.13 FMNL3 FMNL2 FMNL1
3 Rho GTPase binding GO:0017048 8.92 FMNL3 FMNL2 FMNL1 DAAM2

Sources for Malignant Breast Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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