MCID: MLG037
MIFTS: 18

Malignant Childhood Germ Cell Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Malignant Childhood Germ Cell Neoplasm

MalaCards integrated aliases for Malignant Childhood Germ Cell Neoplasm:

Name: Malignant Childhood Germ Cell Neoplasm 12 15
Malignant Pediatric Germ Cell Tumor 12
Malignant Childhood Germ Cell Tumor 72

Classifications:



External Ids:

Disease Ontology 12 DOID:8149
NCIt 50 C6541
UMLS 72 C1334574

Summaries for Malignant Childhood Germ Cell Neoplasm

MalaCards based summary : Malignant Childhood Germ Cell Neoplasm, also known as malignant pediatric germ cell tumor, is related to complete atrioventricular canal-ventricle hypoplasia syndrome and partial atrioventricular canal. An important gene associated with Malignant Childhood Germ Cell Neoplasm is GATA6 (GATA Binding Protein 6), and among its related pathways/superpathways are G-AlphaQ Signaling and DREAM Repression and Dynorphin Expression.

Related Diseases for Malignant Childhood Germ Cell Neoplasm

Graphical network of the top 20 diseases related to Malignant Childhood Germ Cell Neoplasm:



Diseases related to Malignant Childhood Germ Cell Neoplasm

Symptoms & Phenotypes for Malignant Childhood Germ Cell Neoplasm

Drugs & Therapeutics for Malignant Childhood Germ Cell Neoplasm

Search Clinical Trials , NIH Clinical Center for Malignant Childhood Germ Cell Neoplasm

Genetic Tests for Malignant Childhood Germ Cell Neoplasm

Anatomical Context for Malignant Childhood Germ Cell Neoplasm

Publications for Malignant Childhood Germ Cell Neoplasm

Articles related to Malignant Childhood Germ Cell Neoplasm:

# Title Authors PMID Year
1
Detection of chromosome aberrations in paraffin sections of seven gonadal yolk sac tumors of childhood. 38
8522320 1995

Variations for Malignant Childhood Germ Cell Neoplasm

Expression for Malignant Childhood Germ Cell Neoplasm

Search GEO for disease gene expression data for Malignant Childhood Germ Cell Neoplasm.

Pathways for Malignant Childhood Germ Cell Neoplasm

GO Terms for Malignant Childhood Germ Cell Neoplasm

Biological processes related to Malignant Childhood Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.48 GATA6 GATA4
2 response to drug GO:0042493 9.43 GATA6 GATA4
3 blood coagulation GO:0007596 9.4 GATA6 GATA4
4 positive regulation of angiogenesis GO:0045766 9.37 GATA6 GATA4
5 male gonad development GO:0008584 9.32 GATA6 GATA4
6 transcription by RNA polymerase II GO:0006366 9.16 GATA6
7 cardiac muscle cell differentiation GO:0055007 9.16 GATA6 GATA4
8 positive regulation of BMP signaling pathway GO:0030513 8.96 GATA4
9 intestinal epithelial cell differentiation GO:0060575 8.96 GATA6 GATA4
10 positive regulation of cardioblast differentiation GO:0051891 8.62 GATA6 GATA4

Molecular functions related to Malignant Childhood Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.37 GATA6 GATA4
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.32 GATA6 GATA4
3 protein kinase binding GO:0019901 9.26 GATA6 GATA4
4 transcription factor binding GO:0008134 9.16 GATA6 GATA4
5 transcription regulatory region DNA binding GO:0044212 8.96 GATA6 GATA4
6 enhancer sequence-specific DNA binding GO:0001158 8.32 GATA4

Sources for Malignant Childhood Germ Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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