MCID: MLG037
MIFTS: 18

Malignant Childhood Germ Cell Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Malignant Childhood Germ Cell Neoplasm

MalaCards integrated aliases for Malignant Childhood Germ Cell Neoplasm:

Name: Malignant Childhood Germ Cell Neoplasm 12 15
Malignant Pediatric Germ Cell Tumor 12
Malignant Childhood Germ Cell Tumor 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8149
NCIt 49 C6541
UMLS 71 C1334574

Summaries for Malignant Childhood Germ Cell Neoplasm

MalaCards based summary : Malignant Childhood Germ Cell Neoplasm, also known as malignant pediatric germ cell tumor, is related to complete atrioventricular canal-ventricle hypoplasia syndrome and partial atrioventricular canal. An important gene associated with Malignant Childhood Germ Cell Neoplasm is GATA6 (GATA Binding Protein 6), and among its related pathways/superpathways are DREAM Repression and Dynorphin Expression and G-AlphaQ Signaling. Affiliated tissues include heart.

Related Diseases for Malignant Childhood Germ Cell Neoplasm

Graphical network of the top 20 diseases related to Malignant Childhood Germ Cell Neoplasm:



Diseases related to Malignant Childhood Germ Cell Neoplasm

Symptoms & Phenotypes for Malignant Childhood Germ Cell Neoplasm

Drugs & Therapeutics for Malignant Childhood Germ Cell Neoplasm

Search Clinical Trials , NIH Clinical Center for Malignant Childhood Germ Cell Neoplasm

Genetic Tests for Malignant Childhood Germ Cell Neoplasm

Anatomical Context for Malignant Childhood Germ Cell Neoplasm

MalaCards organs/tissues related to Malignant Childhood Germ Cell Neoplasm:

40
Heart

Publications for Malignant Childhood Germ Cell Neoplasm

Articles related to Malignant Childhood Germ Cell Neoplasm:

# Title Authors PMID Year
1
Detection of chromosome aberrations in paraffin sections of seven gonadal yolk sac tumors of childhood. 61
8522320 1995

Variations for Malignant Childhood Germ Cell Neoplasm

Expression for Malignant Childhood Germ Cell Neoplasm

Search GEO for disease gene expression data for Malignant Childhood Germ Cell Neoplasm.

Pathways for Malignant Childhood Germ Cell Neoplasm

Pathways related to Malignant Childhood Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12 GATA6 GATA4
2
Show member pathways
11.96 GATA6 GATA4
3
Show member pathways
11.8 GATA6 GATA4
4 11.45 GATA6 GATA4
5 10.78 GATA6 GATA4
6 10.64 GATA6 GATA4
7 10.29 GATA6 GATA4

GO Terms for Malignant Childhood Germ Cell Neoplasm

Biological processes related to Malignant Childhood Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.46 GATA6 GATA4
2 response to drug GO:0042493 9.43 GATA6 GATA4
3 blood coagulation GO:0007596 9.4 GATA6 GATA4
4 positive regulation of angiogenesis GO:0045766 9.37 GATA6 GATA4
5 male gonad development GO:0008584 9.32 GATA6 GATA4
6 cardiac muscle cell differentiation GO:0055007 9.26 GATA6 GATA4
7 cardiac muscle tissue development GO:0048738 9.16 GATA6 GATA4
8 intestinal epithelial cell differentiation GO:0060575 8.96 GATA6 GATA4
9 positive regulation of cardioblast differentiation GO:0051891 8.62 GATA6 GATA4

Molecular functions related to Malignant Childhood Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.26 GATA6 GATA4
2 protein kinase binding GO:0019901 9.16 GATA6 GATA4
3 transcription factor binding GO:0008134 8.96 GATA6 GATA4
4 transcription regulatory region DNA binding GO:0044212 8.62 GATA6 GATA4

Sources for Malignant Childhood Germ Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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