MCID: MLG062
MIFTS: 29

Malignant Ciliary Body Melanoma

Categories: Cancer diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Malignant Ciliary Body Melanoma

MalaCards integrated aliases for Malignant Ciliary Body Melanoma:

Name: Malignant Ciliary Body Melanoma 12 15
Malignant Melanoma of Ciliary Body 12
Melanoma of the Ciliary Body 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6524
NCIt 50 C4558
SNOMED-CT 67 255015006
UMLS 70 C0346379

Summaries for Malignant Ciliary Body Melanoma

MalaCards based summary : Malignant Ciliary Body Melanoma, also known as malignant melanoma of ciliary body, is related to eye disease and neovascular glaucoma. An important gene associated with Malignant Ciliary Body Melanoma is PROX1 (Prospero Homeobox 1), and among its related pathways/superpathways are Focal Adhesion and MAPK signaling pathway. Affiliated tissues include eye, and related phenotypes are Synthetic lethal with gemcitabine and cardiovascular system

Related Diseases for Malignant Ciliary Body Melanoma

Diseases related to Malignant Ciliary Body Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 eye disease 29.4 TYR KDR FLT1
2 neovascular glaucoma 29.4 VEGFD KDR FLT1
3 ciliary body spindle cell melanoma 11.4
4 melanoma, uveal 10.3
5 retinal detachment 10.2
6 acquired hemangioma 10.1 PROX1 LYVE1
7 intramuscular hemangioma 10.1 PROX1 LYVE1
8 capillary lymphangioma 10.1 PROX1 LYVE1
9 lymphangiosarcoma 10.1 PROX1 LYVE1
10 melanoma 10.1
11 hypotrichosis-lymphedema-telangiectasia syndrome 10.1 PROX1 LYVE1
12 breast angiosarcoma 10.1 PROX1 KDR
13 kaposiform hemangioendothelioma 10.1 PROX1 KDR
14 lymphedema-distichiasis syndrome 10.1 PROX1 LYVE1
15 lens subluxation 10.1
16 hemosiderosis 10.1
17 panophthalmitis 10.1
18 chromoblastomycosis 10.1
19 ocular melanoma 10.1
20 epithelioid cell melanoma 10.1
21 medulloepithelioma 10.1
22 cataract 10.1
23 iridocyclitis 10.1
24 rare tumor 10.1
25 hennekam syndrome 10.1 PROX1 LYVE1
26 angiokeratoma of fordyce 10.0 PROX1 FLT1
27 septate uterus 10.0 KDR FLT1
28 angiokeratoma of mibelli 10.0 KDR FLT1
29 angiokeratoma circumscriptum 10.0 KDR FLT1
30 epithelioid hemangioendothelioma 9.9 KDR FLT1
31 primary cutaneous b-cell lymphoma 9.9 KDR FLT1
32 lung non-squamous non-small cell carcinoma 9.9 KDR FLT1
33 gastroesophageal junction adenocarcinoma 9.9 KDR FLT1
34 retinal vascular occlusion 9.9 KDR FLT1
35 intussusception 9.9 KDR FLT1
36 macular retinal edema 9.9 KDR FLT1
37 placenta accreta 9.9 KDR FLT1
38 retinal artery occlusion 9.9 KDR FLT1
39 vascular cancer 9.9 KDR FLT1
40 arteriovenous malformations of the brain 9.9 KDR FLT1
41 degeneration of macula and posterior pole 9.9 KDR FLT1
42 placental insufficiency 9.9 KDR FLT1
43 breast carcinoma in situ 9.9 KDR FLT1
44 lymphangioma 9.8 PROX1 LYVE1 KDR
45 retinal vascular disease 9.8 KDR FLT1
46 keratitis, hereditary 9.8 LYVE1 FLT1
47 anal canal squamous cell carcinoma 9.8 VEGFD FLT1
48 angiomyolipoma 9.8 VEGFD TYR
49 twin-to-twin transfusion syndrome 9.8 VEGFD FLT1
50 capillary disease 9.8 PROX1 KDR FLT1

Graphical network of the top 20 diseases related to Malignant Ciliary Body Melanoma:



Diseases related to Malignant Ciliary Body Melanoma

Symptoms & Phenotypes for Malignant Ciliary Body Melanoma

GenomeRNAi Phenotypes related to Malignant Ciliary Body Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with gemcitabine GR00225-A 8.62 FLT1 KDR

MGI Mouse Phenotypes related to Malignant Ciliary Body Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.63 FLT1 KDR LYVE1 PROX1 TYR VEGFD
2 immune system MP:0005387 9.43 FLT1 KDR LYVE1 PROX1 TYR VEGFD
3 normal MP:0002873 9.02 FLT1 KDR PROX1 TYR VEGFD

Drugs & Therapeutics for Malignant Ciliary Body Melanoma

Search Clinical Trials , NIH Clinical Center for Malignant Ciliary Body Melanoma

Genetic Tests for Malignant Ciliary Body Melanoma

Anatomical Context for Malignant Ciliary Body Melanoma

MalaCards organs/tissues related to Malignant Ciliary Body Melanoma:

40
Eye

Publications for Malignant Ciliary Body Melanoma

Articles related to Malignant Ciliary Body Melanoma:

(show top 50) (show all 59)
# Title Authors PMID Year
1
Yield, Techniques, and Complications of Transvitreal and Transscleral Biopsies in Small Uveal Melanoma. 61
29596552 2018
2
Advanced Midzonal Iris Pigment Epithelial Cyst Managed by Aspiration Deflation. 61
29765951 2018
3
Ciliary body melanoma treatment by stereotactic radiosurgery. 61
30541301 2018
4
Multicavitary ciliary body melanoma presenting as a cyst. 61
23772126 2013
5
Chromoblastomycosis of the conjunctiva mimicking melanoma of the ciliary body. 61
23229710 2012
6
Ocular melanoma. 61
21128775 2010
7
Intraocular lymphatics in ciliary body melanomas with extraocular extension: functional for lymphatic spread? 61
20697000 2010
8
Intraocular tumor-associated lymphangiogenesis a novel prognostic factor for ciliary body melanomas with extraocular extension? 61
19892405 2010
9
Intraocular lymphangiogenesis in malignant melanomas of the ciliary body with extraocular extension. 61
19151383 2009
10
[Mesectodermal leiomyoma of the ciliary body--case report]. 61
20169895 2009
11
[Immunohistochemical detection of the gene p53 and p21 expression in cells of the malignant melanoma of the uvea]. 61
18780655 2008
12
Ring melanoma of the ciliary body: clinical and ultrasound biomicroscopic characteristics. 61
18347629 2008
13
Iris melanoma. 61
18251588 2008
14
Ciliary body melanoma with limited nodular extrascleral extension and diffuse iris-angle infiltration treated by whole anterior segment plaque radiotherapy. 61
17468833 2007
15
Malignant melanoma of the ciliary body presenting as extraocular metastasis in the temporalis muscle. 61
17545559 2007
16
Possible shared pathogenesis of the retinoinvasive phenotype of malignant medulloepithelioma and malignant melanoma of the ciliary body. 61
16832040 2006
17
Oral metastasis of ciliary body melanoma. A case report. 61
16971885 2006
18
[Intracorneal invasion of the ciliary body by melanoma]. 61
16523149 2006
19
Incidence of noncutaneous melanomas in the U.S. 61
15651058 2005
20
Ultrasound biomicroscopic findings of ciliary body malignant melanoma. 61
15295673 2004
21
Ring melanoma of the ciliary body: report on twenty-three patients. 61
12476094 2002
22
[Detection of tumor circulating cells in patients with ocular melanoma]. 61
12181879 2002
23
Ciliary body tumor and cataract: local resection combined with phacoemulsification. 61
11408147 2001
24
[Malignant melanoma of the ciliary body. A diagnostic problem]. 61
11374285 2001
25
Ring melanoma--a rare cause of refractory glaucoma. 61
10396198 1999
26
Microvascular loops and networks as prognostic indicators in choroidal and ciliary body melanomas. 61
10050870 1999
27
Cavitary melanoma of the ciliary body. A study of eight cases. 61
9627662 1998
28
Malignant nonteratoid medulloepithelioma of the ciliary body in an adult. 61
9544630 1998
29
[Ophthalmology quiz. Intraocular tumor, most probably melanoma of the ciliary body]. 61
9531668 1998
30
Retinoinvasive malignant melanoma of the uvea. 61
9349160 1997
31
[Ring recurrence of ciliary body melanoma after proton-beam therapy]. 61
9587582 1997
32
Panophthalmitis with acute scleral necrosis after brachytherapy of a malignant melanoma of the ciliary body. 61
8751105 1995
33
Mixed cell malignant melanoma of the ciliary body. 61
8929636 1995
34
Current management of posterior uveal melanoma. 61
8246622 1993
35
Decreased choroidal thickness in eyes with secondary angle closure glaucoma. An aetiological factor for deep retinal changes in glaucoma? 61
8343472 1993
36
Reduction in number of corpora amylacea with advancing histological changes of glaucoma. 61
8391507 1993
37
[Differential intraocular tumor diagnosis in MRI using gadolinium DTPA: value in comparison with other ophthalmologic examination procedures]. 61
2045026 1991
38
Ciliary body melanoma with optic nerve invasion. 61
2310725 1990
39
[Neovascular glaucoma: an uncommon manifestation of melanoma of the ciliary body]. 61
2350862 1990
40
[Homolateral episcleral metastasis or surgical seeding of a proton-irradiated ciliary body melanoma?]. 61
2841533 1988
41
Prognostic factors in choroidal and ciliary body melanomas with extrascleral extension. 61
3953727 1986
42
[Echographic findings in cyclitis annularis pseudotumorosa and ring melanoma of the ciliary body]. 61
3910948 1985
43
A clinicopathologic case of cyclectomy for malignant melanoma of the ciliary body, complicated by total traction retinal detachment. 61
4062163 1985
44
Cataract surgery and intraocular lenses in patients with unsuspected malignant melanoma of the ciliary body and choroid. 61
4034177 1985
45
Blurred vision associated with melanoma of the ciliary body. 61
3998370 1985
46
A xanthomatous lesion resembling balloon cell melanoma of the iris and ciliary body of a dog. 61
3837792 1985
47
Anatomic features of the eye disclosed with nuclear magnetic resonance imaging. 61
6704009 1984
48
Adenoma of the nonpigmented epithelium of the ciliary body. 61
6677852 1983
49
[Displacement of the iris root: a frequent sign of the anterior spread of a tumor of the ciliary body]. 61
6630891 1983
50
Proton-beam irradiated epithelioid cell melanoma of the ciliary body. 61
6275325 1981

Variations for Malignant Ciliary Body Melanoma

Expression for Malignant Ciliary Body Melanoma

Search GEO for disease gene expression data for Malignant Ciliary Body Melanoma.

Pathways for Malignant Ciliary Body Melanoma

Pathways related to Malignant Ciliary Body Melanoma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 VEGFD KDR FLT1
2 12.37 VEGFD KDR FLT1
3
Show member pathways
12.33 VEGFD KDR FLT1
4
Show member pathways
12.29 VEGFD KDR FLT1
5
Show member pathways
12.01 VEGFD KDR FLT1
6
Show member pathways
11.98 VEGFD KDR FLT1
7
Show member pathways
11.88 VEGFD KDR FLT1
8
Show member pathways
11.86 VEGFD KDR FLT1
9 11.81 VEGFD KDR FLT1
10
Show member pathways
11.53 KDR FLT1
11
Show member pathways
11.47 KDR FLT1
12 11.09 KDR FLT1
13 11.08 PROX1 KDR FLT1
14
Show member pathways
10.94 KDR FLT1
15 10.9 KDR FLT1
16 10.64 VEGFD KDR FLT1
17 10.54 KDR FLT1
18
Show member pathways
10 VEGFD KDR FLT1

GO Terms for Malignant Ciliary Body Melanoma

Biological processes related to Malignant Ciliary Body Melanoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.76 VEGFD PROX1 KDR FLT1
2 angiogenesis GO:0001525 9.58 VEGFD KDR FLT1
3 positive regulation of cell proliferation GO:0008284 9.56 VEGFD PROX1 KDR FLT1
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.52 KDR FLT1
5 positive regulation of kinase activity GO:0033674 9.51 KDR FLT1
6 positive regulation of angiogenesis GO:0045766 9.5 VEGFD KDR FLT1
7 positive regulation of endothelial cell migration GO:0010595 9.49 PROX1 KDR
8 hematopoietic progenitor cell differentiation GO:0002244 9.48 KDR FLT1
9 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.43 KDR FLT1
10 endothelial cell differentiation GO:0045446 9.37 PROX1 KDR
11 positive regulation of endothelial cell proliferation GO:0001938 9.33 VEGFD PROX1 KDR
12 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.13 VEGFD KDR FLT1
13 vascular endothelial growth factor signaling pathway GO:0038084 8.8 VEGFD KDR FLT1

Molecular functions related to Malignant Ciliary Body Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 KDR FLT1
2 growth factor binding GO:0019838 8.96 KDR FLT1
3 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 KDR FLT1

Sources for Malignant Ciliary Body Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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