MCID: MLG142
MIFTS: 42

Malignant Conjunctival Melanoma

Categories: Cancer diseases, Eye diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Malignant Conjunctival Melanoma

MalaCards integrated aliases for Malignant Conjunctival Melanoma:

Name: Malignant Conjunctival Melanoma 12 15
Malignant Melanoma of Conjunctiva 12 73
Conjunctival Melanoma 12 53

Classifications:



External Ids:

Disease Ontology 12 DOID:1751
NCIt 50 C4550
UMLS 73 C0346360

Summaries for Malignant Conjunctival Melanoma

MalaCards based summary : Malignant Conjunctival Melanoma, also known as malignant melanoma of conjunctiva, is related to malignant spindle cell melanoma and melanoma, uveal. An important gene associated with Malignant Conjunctival Melanoma is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and TGF-Beta Pathway. The drugs Pancrelipase and Melphalan have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and skin, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Malignant Conjunctival Melanoma

Diseases related to Malignant Conjunctival Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 malignant spindle cell melanoma 29.8 NRAS SOX10
2 melanoma, uveal 29.6 GNA11 GNAQ NRAS
3 ocular melanoma 11.2
4 giant congenital nevus 10.1 HRAS NRAS
5 benign struma ovarii 10.1 HRAS NRAS
6 schimmelpenning-feuerstein-mims syndrome 10.1 HRAS NRAS
7 ovarian melanoma 10.1 HRAS NRAS
8 marcus gunn phenomenon 10.1 HRAS NRAS
9 malignant struma ovarii 10.1 HRAS NRAS
10 fetal adenoma 10.1 HRAS NRAS
11 myelodysplastic myeloproliferative cancer 10.1 HRAS NRAS
12 melanocytic nevus syndrome, congenital 10.1 HRAS NRAS
13 vulvar melanoma 10.1 HRAS NRAS
14 core binding factor acute myeloid leukemia 10.1 HRAS NRAS
15 liver angiosarcoma 10.1 HRAS NRAS
16 small cell sarcoma 10.1 NRAS SOX10
17 paronychia 10.1 HRAS MAP2K7
18 melanoma 10.1
19 phakomatosis cesioflammea 10.0 GNA11 GNAQ
20 intraocular melanoma 10.0 GNA11 GNAQ
21 melanoma metastasis 10.0
22 malignant skin fibrous histiocytoma 10.0 HRAS IFNA2 NRAS
23 malignant dermis tumor 10.0 HRAS IFNA2 NRAS
24 nevus, epidermal 10.0 HRAS NRAS
25 nodular malignant melanoma 10.0 GNAQ HRAS NRAS
26 exanthem 10.0 HRAS MAP2K7
27 leukemia, chronic myeloid 10.0 HRAS IFNA2 NRAS
28 lentigo maligna melanoma 10.0
29 cardiofaciocutaneous syndrome 1 10.0 HRAS MAP2K7
30 uveal disease 9.9 GNA11 GNAQ
31 acneiform dermatitis 9.9 HRAS MAP2K7 NRAS
32 mucosal melanoma 9.9 GNA11 GNAQ NRAS
33 meningeal melanocytoma 9.9 GNA11 GNAQ NRAS
34 large intestine cancer 9.9 HRAS MAP2K7 NRAS
35 neurofibromatosis, type i 9.8
36 retinoblastoma 9.8
37 b-cell lymphomas 9.8
38 marginal zone b-cell lymphoma 9.8
39 primary amebic meningoencephalitis 9.8
40 conjunctival nevus 9.8
41 lymphoma 9.8
42 pinguecula 9.8
43 corneal argyrosis 9.8
44 conjunctival squamous cell carcinoma 9.8
45 squamous cell carcinoma 9.8
46 mycetoma 9.8
47 ocular cancer 9.8 GNA11 GNAQ
48 conjunctival cancer 9.8 GNA11 GNAQ IFNA2 NRAS
49 melanomatosis 9.8 GNA11 GNAQ HRAS NRAS
50 leukemia, acute myeloid 9.8 HRAS MAP2K7 NRAS

Graphical network of the top 20 diseases related to Malignant Conjunctival Melanoma:



Diseases related to Malignant Conjunctival Melanoma

Symptoms & Phenotypes for Malignant Conjunctival Melanoma

GenomeRNAi Phenotypes related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.68 SOX10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.68 GNA11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.68 GNA11 NRAS SOX10
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.68 NRAS
5 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.68 GNA11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.68 GNA11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.68 GNA11
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.68 NRAS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.68 SOX10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.68 NRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.68 NRAS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.68 SOX10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.68 SOX10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.68 GNA11
15 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.68 NRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.68 NRAS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.68 SOX10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.68 SOX10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.68 GNA11
20 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.68 SOX10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.68 SOX10

MGI Mouse Phenotypes related to Malignant Conjunctival Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.98 GNA11 GNAQ HRAS MAP2K7 NRAS PDCD1
2 homeostasis/metabolism MP:0005376 9.95 GNA11 GNAQ HRAS MAP2K7 NRAS PDCD1
3 behavior/neurological MP:0005386 9.93 GNA11 GNAQ HRAS MAP2K7 NRAS SOX10
4 mortality/aging MP:0010768 9.87 GNA11 GNAQ HRAS MAP2K7 NRAS PDCD1
5 integument MP:0010771 9.85 GNA11 GNAQ HRAS MAP2K7 NRAS SOX10
6 neoplasm MP:0002006 9.65 HRAS MAP2K7 NRAS PDCD1 SOX10
7 normal MP:0002873 9.63 GNA11 GNAQ HRAS MAP2K7 NRAS SOX10
8 pigmentation MP:0001186 9.26 GNA11 GNAQ NRAS SOX10
9 respiratory system MP:0005388 9.02 GNA11 GNAQ HRAS PDCD1 SOX10

Drugs & Therapeutics for Malignant Conjunctival Melanoma

Drugs for Malignant Conjunctival Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 2 53608-75-6
2
Melphalan Approved Phase 2 148-82-3 4053 460612
3
Cyclophosphamide Approved, Investigational Phase 2,Phase 1,Early Phase 1 6055-19-2, 50-18-0 2907
4
Lenalidomide Approved Phase 2 191732-72-6 216326
5
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
6 Pancreatic Polypeptide Investigational Phase 2 59763-91-6
7 Antineoplastic Agents, Alkylating Phase 2,Phase 1,Early Phase 1
8 Alkylating Agents Phase 2,Phase 1,Early Phase 1
9 Cola Phase 2,Early Phase 1
10 Liver Extracts Phase 2,Early Phase 1
11 Immunologic Factors Phase 2,Phase 1,Early Phase 1
12 Immunosuppressive Agents Phase 2,Phase 1,Early Phase 1
13 pancreatin Phase 2
14 Antirheumatic Agents Phase 2,Phase 1,Early Phase 1
15 Angiogenesis Modulating Agents Phase 2
16 Angiogenesis Inhibitors Phase 2
17 Anti-Infective Agents Phase 2
18 Anti-Bacterial Agents Phase 2
19 Imatinib Mesylate Phase 1 220127-57-1 123596
20 Protein Kinase Inhibitors Phase 1
21 Freund's Adjuvant Phase 1
22 Adjuvants, Immunologic Phase 1
23 Vaccines Phase 1
24 CPG-oligonucleotide Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer Completed NCT00096083 Phase 2 isolated perfusion;melphalan
2 Lenalidomide, Sunitinib, and Cyclophosphamide in Treating Patients With Stage IV Eye Melanoma Terminated NCT00482911 Phase 2 cyclophosphamide;lenalidomide;sunitinib malate
3 Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib Mesylate Completed NCT01046487 Phase 1 Imatinib mesylate, Cyclophosphamide (Dosing level 1 );Imatinib mesylate, Cyclophosphamide (Dosing level 2);Imatinib mesylate, Cyclophosphamide (Dosing level 3)
4 Vaccine Therapy in Treating Patients With Advanced Melanoma Completed NCT00705640 Phase 1
5 Vaccine Therapy in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery Completed NCT00471471 Phase 1
6 Sentinel Lymph Node (SLN) Biopsy for Conjunctival/Eyelid Melanoma Active, not recruiting NCT00386906 Phase 1
7 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Terminated NCT00499733 Early Phase 1 cyclophosphamide

Search NIH Clinical Center for Malignant Conjunctival Melanoma

Genetic Tests for Malignant Conjunctival Melanoma

Anatomical Context for Malignant Conjunctival Melanoma

MalaCards organs/tissues related to Malignant Conjunctival Melanoma:

41
Liver, Eye, Skin, Lymph Node, Colon, B Cells, Myeloid

Publications for Malignant Conjunctival Melanoma

Articles related to Malignant Conjunctival Melanoma:

(show all 13)
# Title Authors Year
1
Malignant melanoma of conjunctiva: Diagnosis on fine-needle aspiration cytology. ( 30498321 )
2018
2
Amelanotic corneally displaced malignant conjunctival melanoma: a case report evaluated with impression cytology. ( 25076376 )
2014
3
Malignant melanoma of conjunctiva--a case report. ( 15871362 )
2004
4
Malignant melanoma of conjunctiva with xeroderma pigmentosa--a case report. ( 9018995 )
1996
5
Malignant conjunctival melanoma. A case report. ( 3237135 )
1988
6
Malignant melanoma of conjunctiva following surgical excision of naevus. ( 3842836 )
1985
7
Multifocal primary malignant melanoma of conjunctiva. ( 6500663 )
1984
8
Light and electron microscopic studies of malignant melanoma of conjunctiva and palpebra. ( 6656010 )
1983
9
Malignant melanoma of conjunctiva metastatic to parotid gland. Reports of cases and discussion of surgical management. ( 926964 )
1977
10
Pedunculated malignant melanoma of conjunctiva - the sequel. ( 1122422 )
1975
11
Malignant melanoma of conjunctiva. ( 15744963 )
1971
12
Pedunculated malignant melanoma of conjunctiva. ( 5481550 )
1970
13
Malignant melanoma of conjunctiva in eye of Negro patient. ( 13844113 )
1959

Variations for Malignant Conjunctival Melanoma

Expression for Malignant Conjunctival Melanoma

Search GEO for disease gene expression data for Malignant Conjunctival Melanoma.

Pathways for Malignant Conjunctival Melanoma

Pathways related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.67 GNA11 GNAQ HRAS IFNA2 MAP2K7 NRAS
2
Show member pathways
13.36 GNA11 HRAS IFNA2 MAP2K7 NRAS
3
Show member pathways
13.13 GNA11 GNAQ HRAS IFNA2 NRAS
4
Show member pathways
13.02 GNA11 GNAQ HRAS MAP2K7 NRAS
5
Show member pathways
12.93 GNA11 GNAQ HRAS NRAS
6
Show member pathways
12.85 GNA11 GNAQ IFNA2 MAP2K7
7
Show member pathways
12.83 GNA11 GNAQ HRAS MAP2K7 NRAS
8
Show member pathways
12.81 GNA11 GNAQ HRAS MAP2K7 NRAS
9
Show member pathways
12.77 GNA11 GNAQ HRAS NRAS
10
Show member pathways
12.76 GNA11 GNAQ HRAS MAP2K7 NRAS
11
Show member pathways
12.72 GNA11 HRAS MAP2K7 NRAS
12
Show member pathways
12.65 GNA11 HRAS MAP2K7 NRAS
13
Show member pathways
12.62 GNA11 GNAQ HRAS IFNA2 MAP2K7 NRAS
14 12.6 GNA11 GNAQ HRAS IFNA2 NRAS
15
Show member pathways
12.55 GNA11 GNAQ HRAS NRAS
16
Show member pathways
12.45 HRAS MAP2K7 NRAS
17
Show member pathways
12.44 GNA11 GNAQ HRAS MAP2K7
18
Show member pathways
12.42 GNA11 GNAQ HRAS MAP2K7 NRAS
19
Show member pathways
12.4 HRAS MAP2K7 NRAS
20
Show member pathways
12.39 HRAS IFNA2 NRAS
21
Show member pathways
12.35 HRAS MAP2K7 NRAS
22
Show member pathways
12.31 HRAS MAP2K7 NRAS
23
Show member pathways
12.29 HRAS MAP2K7 NRAS
24
Show member pathways
12.28 HRAS MAP2K7 NRAS
25
Show member pathways
12.27 HRAS IFNA2 NRAS
26
Show member pathways
12.23 HRAS MAP2K7 NRAS PDCD1
27
Show member pathways
12.22 GNA11 GNAQ HRAS NRAS
28
Show member pathways
12.2 GNA11 GNAQ HRAS
29
Show member pathways
12.13 HRAS MAP2K7 NRAS
30
Show member pathways
12.11 HRAS MAP2K7 NRAS
31
Show member pathways
12.07 HRAS MAP2K7 NRAS
32
Show member pathways
12.07 GNAQ HRAS NRAS
33
Show member pathways
12.02 HRAS MAP2K7 NRAS
34
Show member pathways
12 GNA11 GNAQ HRAS MAP2K7 NRAS
35 11.96 GNAQ HRAS NRAS
36 11.94 HRAS IFNA2 NRAS
37 11.89 HRAS MAP2K7 NRAS
38
Show member pathways
11.88 GNA11 GNAQ HRAS
39 11.85 GNAQ HRAS NRAS
40
Show member pathways
11.85 GNA11 GNAQ HRAS NRAS
41 11.83 GNAQ HRAS NRAS
42
Show member pathways
11.8 GNA11 GNAQ HRAS MAP2K7
43 11.75 HRAS IFNA2 NRAS
44 11.68 GNAQ HRAS MAP2K7 NRAS
45 11.57 GNA11 GNAQ HRAS NRAS
46 11.54 GNA11 GNAQ HRAS
47 11.5 HRAS NRAS
48 11.46 HRAS MAP2K7 NRAS
49 11.45 GNA11 GNAQ
50 11.42 HRAS NRAS

GO Terms for Malignant Conjunctival Melanoma

Cellular components related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heterotrimeric G-protein complex GO:0005834 8.62 GNA11 GNAQ

Biological processes related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.77 GNA11 GNAQ HRAS MAP2K7 NRAS
2 apoptotic process GO:0006915 9.62 HRAS IFNA2 MAP2K7 PDCD1
3 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.4 GNA11 GNAQ
4 action potential GO:0001508 9.26 GNA11 GNAQ
5 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.16 GNA11 GNAQ
6 phototransduction, visible light GO:0007603 8.96 GNA11 GNAQ
7 entrainment of circadian clock GO:0009649 8.62 GNA11 GNAQ

Molecular functions related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 GNA11 GNAQ HRAS NRAS
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNA11 GNAQ
3 guanyl nucleotide binding GO:0019001 9.26 GNA11 GNAQ
4 GTPase activity GO:0003924 9.26 GNA11 GNAQ HRAS NRAS
5 type 2A serotonin receptor binding GO:0031826 8.62 GNA11 GNAQ

Sources for Malignant Conjunctival Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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