MCID: MLG142
MIFTS: 39

Malignant Conjunctival Melanoma

Categories: Rare diseases, Neuronal diseases, Cancer diseases, Eye diseases, Skin diseases

Aliases & Classifications for Malignant Conjunctival Melanoma

MalaCards integrated aliases for Malignant Conjunctival Melanoma:

Name: Malignant Conjunctival Melanoma 12 15
Malignant Melanoma of Conjunctiva 12 73
Conjunctival Melanoma 12 53

Classifications:



External Ids:

Disease Ontology 12 DOID:1751
NCIt 50 C4550
SNOMED-CT 68 255004001
UMLS 73 C0346360

Summaries for Malignant Conjunctival Melanoma

MalaCards based summary : Malignant Conjunctival Melanoma, also known as malignant melanoma of conjunctiva, is related to ocular melanoma and giant congenital nevus. An important gene associated with Malignant Conjunctival Melanoma is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and TGF-Beta Pathway. The drugs Cyclophosphamide and Melphalan have been mentioned in the context of this disorder. Affiliated tissues include eye, liver and lymph node, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Malignant Conjunctival Melanoma

Diseases related to Malignant Conjunctival Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 ocular melanoma 11.1
2 giant congenital nevus 10.5 HRAS NRAS
3 benign struma ovarii 10.4 HRAS NRAS
4 schimmelpenning-feuerstein-mims syndrome 10.4 HRAS NRAS
5 ovarian melanoma 10.4 HRAS NRAS
6 marcus gunn phenomenon 10.4 HRAS NRAS
7 malignant struma ovarii 10.4 HRAS NRAS
8 myelodysplastic myeloproliferative cancer 10.3 HRAS NRAS
9 nevus, epidermal 10.3 HRAS NRAS
10 melanocytic nevus syndrome, congenital 10.3 HRAS NRAS
11 malignant spindle cell melanoma 10.3 NRAS SOX10
12 vulvar melanoma 10.3 HRAS NRAS
13 syringomyelia 10.3 CD2AP NRAS
14 core binding factor acute myeloid leukemia 10.2 HRAS NRAS
15 liver angiosarcoma 10.2 HRAS NRAS
16 small cell sarcoma 10.2 NRAS SOX10
17 adenosquamous pancreas carcinoma 10.2 HRAS IFNA2
18 penile cancer 10.1 HRAS IFNA2
19 paronychia 10.1 HRAS MAP2K7
20 melanoma 10.0
21 phakomatosis cesioflammea 10.0 GNA11 GNAQ
22 malignant skin fibrous histiocytoma 10.0 HRAS IFNA2 NRAS
23 malignant dermis tumor 10.0 HRAS IFNA2 NRAS
24 intraocular melanoma 10.0 GNA11 GNAQ
25 melanoma, cutaneous malignant 1 10.0 HRAS IFNA2 NRAS
26 dyschromatosis symmetrica hereditaria 9.9 HRAS SOX10
27 leukemia, chronic myeloid 9.9 HRAS IFNA2 NRAS
28 acneiform dermatitis 9.7 HRAS MAP2K7 NRAS
29 cell type cancer 9.7 HRAS MAP2K7 NRAS
30 noonan syndrome 1 9.7 HRAS MAP2K7 NRAS
31 sensory system cancer 9.6 GNA11 GNAQ
32 mucosal melanoma 9.6 GNA11 GNAQ NRAS
33 meningeal melanocytoma 9.6 GNA11 GNAQ NRAS
34 melanoma, uveal 9.6 GNA11 GNAQ NRAS
35 cardiofaciocutaneous syndrome 1 9.5 HRAS MAP2K7
36 integumentary system cancer 9.3 GNAQ HRAS MAP2K7 NRAS
37 leukemia, acute myeloid 9.3 HRAS MAP2K7 NRAS
38 ocular cancer 9.2 GNA11 GNAQ
39 conjunctival cancer 9.1 GNA11 GNAQ IFNA2 NRAS
40 melanomatosis 9.1 GNA11 GNAQ HRAS NRAS
41 meningeal melanomatosis 9.1 GNA11 GNAQ HRAS NRAS
42 central nervous system melanocytic neoplasm 9.1 GNA11 GNAQ HRAS NRAS
43 skin melanoma 7.7 CD2AP GNA11 GNAQ HRAS MAP2K7 NRAS

Graphical network of the top 20 diseases related to Malignant Conjunctival Melanoma:



Diseases related to Malignant Conjunctival Melanoma

Symptoms & Phenotypes for Malignant Conjunctival Melanoma

GenomeRNAi Phenotypes related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-103 9.68 SOX10
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.68 GNA11
3 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.68 SOX10 GNA11 NRAS
4 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.68 NRAS
5 Increased shRNA abundance (Z-score > 2) GR00366-A-131 9.68 GNA11
6 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.68 GNA11
7 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.68 GNA11
8 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.68 NRAS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.68 SOX10
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.68 NRAS
11 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.68 NRAS
12 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.68 SOX10
13 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.68 SOX10
14 Increased shRNA abundance (Z-score > 2) GR00366-A-52 9.68 GNA11
15 Increased shRNA abundance (Z-score > 2) GR00366-A-54 9.68 NRAS
16 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.68 NRAS
17 Increased shRNA abundance (Z-score > 2) GR00366-A-7 9.68 SOX10
18 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.68 SOX10
19 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.68 GNA11
20 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.68 SOX10
21 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.68 SOX10

MGI Mouse Phenotypes related to Malignant Conjunctival Melanoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.91 GNAQ HRAS MAP2K7 CD2AP NRAS GNA11
2 behavior/neurological MP:0005386 9.88 SOX10 GNAQ HRAS MAP2K7 NRAS GNA11
3 homeostasis/metabolism MP:0005376 9.87 SOX10 GNAQ HRAS MAP2K7 CD2AP NRAS
4 integument MP:0010771 9.73 GNAQ HRAS MAP2K7 NRAS GNA11 SOX10
5 mortality/aging MP:0010768 9.7 SOX10 GNAQ HRAS MAP2K7 CD2AP NRAS
6 normal MP:0002873 9.43 SOX10 GNAQ HRAS MAP2K7 NRAS GNA11
7 pigmentation MP:0001186 8.92 SOX10 GNAQ NRAS GNA11

Drugs & Therapeutics for Malignant Conjunctival Melanoma

Drugs for Malignant Conjunctival Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclophosphamide Approved, Investigational Phase 2,Phase 1,Not Applicable 50-18-0, 6055-19-2 2907
2
Melphalan Approved Phase 2 148-82-3 4053 460612
3
Pancrelipase Approved, Investigational Phase 2 53608-75-6
4
Lenalidomide Approved Phase 2 191732-72-6 216326
5
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
6 Pancreatic Polypeptide Investigational Phase 2 59763-91-6
7 Alkylating Agents Phase 2,Phase 1,Not Applicable
8 Antineoplastic Agents, Alkylating Phase 2,Phase 1,Not Applicable
9 Immunosuppressive Agents Phase 2,Phase 1,Not Applicable
10 Liver Extracts Phase 2,Not Applicable
11 Antirheumatic Agents Phase 2,Phase 1,Not Applicable
12 pancreatin Phase 2
13 Angiogenesis Inhibitors Phase 2
14 Angiogenesis Modulating Agents Phase 2
15 Anti-Bacterial Agents Phase 2
16 Anti-Infective Agents Phase 2
17 Cola Nutraceutical Phase 2,Not Applicable
18 Imatinib Mesylate Phase 1 220127-57-1 123596
19 Protein Kinase Inhibitors Phase 1
20 Adjuvants, Immunologic Phase 1
21 Freund's Adjuvant Phase 1
22 Vaccines Phase 1
23 CPG-oligonucleotide Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Hepatic Arterial Infusion of Melphalan With Hepatic Perfusion in Treating Patients With Unresectable Liver Cancer Completed NCT00096083 Phase 2 isolated perfusion;melphalan
2 Lenalidomide, Sunitinib, and Cyclophosphamide in Treating Patients With Stage IV Eye Melanoma Terminated NCT00482911 Phase 2 cyclophosphamide;lenalidomide;sunitinib malate
3 Imatinib Mesylate And Cyclophosphamide In Metronomic Administration: Dose Escalation Study Of Imatinib Mesylate Completed NCT01046487 Phase 1 Imatinib mesylate, Cyclophosphamide (Dosing level 1 );Imatinib mesylate, Cyclophosphamide (Dosing level 2);Imatinib mesylate, Cyclophosphamide (Dosing level 3)
4 Vaccine Therapy in Treating Patients With Advanced Melanoma Completed NCT00705640 Phase 1
5 Vaccine Therapy in Treating Patients With Recurrent Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery Completed NCT00471471 Phase 1
6 Sentinel Lymph Node (SLN) Biopsy for Conjunctival/Eyelid Melanoma Active, not recruiting NCT00386906 Phase 1
7 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Unknown status NCT00499733 Not Applicable cyclophosphamide

Search NIH Clinical Center for Malignant Conjunctival Melanoma

Genetic Tests for Malignant Conjunctival Melanoma

Anatomical Context for Malignant Conjunctival Melanoma

MalaCards organs/tissues related to Malignant Conjunctival Melanoma:

41
Eye, Liver, Lymph Node

Publications for Malignant Conjunctival Melanoma

Articles related to Malignant Conjunctival Melanoma:

# Title Authors Year
1
Amelanotic corneally displaced malignant conjunctival melanoma: a case report evaluated with impression cytology. ( 25076376 )
2014
2
Malignant conjunctival melanoma. A case report. ( 3237135 )
1988
3
[Up-dating the classification of malignant conjunctival melanomas]. ( 546546 )
1979

Variations for Malignant Conjunctival Melanoma

Expression for Malignant Conjunctival Melanoma

Search GEO for disease gene expression data for Malignant Conjunctival Melanoma.

Pathways for Malignant Conjunctival Melanoma

Pathways related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 GNA11 GNAQ HRAS IFNA2 MAP2K7 NRAS
2
Show member pathways
13.3 GNA11 HRAS IFNA2 MAP2K7 NRAS
3
Show member pathways
13.12 GNA11 GNAQ HRAS IFNA2 NRAS
4
Show member pathways
12.92 GNA11 GNAQ HRAS NRAS
5
Show member pathways
12.85 GNA11 GNAQ HRAS NRAS
6
Show member pathways
12.84 GNA11 GNAQ IFNA2 MAP2K7
7
Show member pathways
12.76 GNA11 GNAQ HRAS NRAS
8
Show member pathways
12.76 GNA11 GNAQ HRAS MAP2K7 NRAS
9
Show member pathways
12.76 GNA11 GNAQ HRAS MAP2K7 NRAS
10
Show member pathways
12.69 GNA11 HRAS MAP2K7 NRAS
11
Show member pathways
12.62 GNA11 HRAS MAP2K7 NRAS
12 12.55 GNA11 GNAQ HRAS IFNA2 NRAS
13
Show member pathways
12.54 GNA11 GNAQ HRAS MAP2K7 NRAS
14
Show member pathways
12.5 GNA11 GNAQ HRAS NRAS
15
Show member pathways
12.44 HRAS MAP2K7 NRAS
16
Show member pathways
12.39 HRAS MAP2K7 NRAS
17
Show member pathways
12.39 GNA11 GNAQ HRAS MAP2K7 NRAS
18
Show member pathways
12.37 HRAS IFNA2 NRAS
19
Show member pathways
12.34 HRAS IFNA2 MAP2K7 NRAS
20
Show member pathways
12.33 HRAS MAP2K7 NRAS
21
Show member pathways
12.3 HRAS MAP2K7 NRAS
22
Show member pathways
12.28 HRAS MAP2K7 NRAS
23
Show member pathways
12.28 HRAS MAP2K7 NRAS
24
Show member pathways
12.27 HRAS MAP2K7 NRAS
25
Show member pathways
12.18 GNA11 GNAQ HRAS
26
Show member pathways
12.08 HRAS MAP2K7 NRAS
27
Show member pathways
12.06 HRAS MAP2K7 NRAS
28
Show member pathways
12.04 GNAQ HRAS NRAS
29
Show member pathways
11.99 HRAS MAP2K7 NRAS
30 11.92 GNAQ HRAS NRAS
31 11.89 HRAS IFNA2 NRAS
32 11.85 HRAS MAP2K7 NRAS
33
Show member pathways
11.83 HRAS MAP2K7 NRAS
34
Show member pathways
11.83 GNA11 GNAQ HRAS
35 11.8 GNAQ HRAS NRAS
36 11.77 GNAQ HRAS NRAS
37
Show member pathways
11.76 GNA11 GNAQ HRAS MAP2K7
38 11.75 HRAS IFNA2 NRAS
39 11.68 GNAQ HRAS MAP2K7 NRAS
40 11.48 HRAS NRAS
41 11.47 GNA11 GNAQ HRAS
42 11.43 GNA11 GNAQ
43 11.4 HRAS NRAS
44 11.36 HRAS MAP2K7
45 11.34 HRAS NRAS
46 11.29 GNA11 GNAQ
47 11.24 GNA11 GNAQ
48 11.22 GNA11 GNAQ
49 11.22 HRAS NRAS
50 11.2 GNA11 GNAQ HRAS NRAS

GO Terms for Malignant Conjunctival Melanoma

Cellular components related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heterotrimeric G-protein complex GO:0005834 8.62 GNA11 GNAQ

Biological processes related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.85 CD2AP GNA11 GNAQ HRAS MAP2K7 NRAS
2 Fc-epsilon receptor signaling pathway GO:0038095 9.63 HRAS MAP2K7 NRAS
3 ERBB2 signaling pathway GO:0038128 9.48 HRAS NRAS
4 action potential GO:0001508 9.43 GNA11 GNAQ
5 G-protein coupled acetylcholine receptor signaling pathway GO:0007213 9.4 GNA11 GNAQ
6 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.32 GNA11 GNAQ
7 developmental pigmentation GO:0048066 9.26 GNA11 GNAQ
8 phototransduction, visible light GO:0007603 9.16 GNA11 GNAQ
9 entrainment of circadian clock GO:0009649 8.96 GNA11 GNAQ
10 regulation of melanocyte differentiation GO:0045634 8.62 GNA11 GNAQ

Molecular functions related to Malignant Conjunctival Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 GNA11 GNAQ HRAS NRAS
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNA11 GNAQ
3 guanyl nucleotide binding GO:0019001 9.26 GNA11 GNAQ
4 GTPase activity GO:0003924 9.26 GNA11 GNAQ HRAS NRAS
5 type 2A serotonin receptor binding GO:0031826 8.62 GNA11 GNAQ

Sources for Malignant Conjunctival Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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