MCID: MLG087
MIFTS: 18

Malignant Cylindroma

Categories: Rare diseases

Aliases & Classifications for Malignant Cylindroma

MalaCards integrated aliases for Malignant Cylindroma:

Name: Malignant Cylindroma 54 74

Classifications:



External Ids:

UMLS 74 C1275214

Summaries for Malignant Cylindroma

MalaCards based summary : Malignant Cylindroma is related to adenoid cystic carcinoma and brooke-spiegler syndrome. An important gene associated with Malignant Cylindroma is COL4A5 (Collagen Type IV Alpha 5 Chain), and among its related pathways/superpathways are Phospholipase-C Pathway and Circadian entrainment. Affiliated tissues include bone.

Related Diseases for Malignant Cylindroma

Diseases related to Malignant Cylindroma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 11.6
2 brooke-spiegler syndrome 10.1

Symptoms & Phenotypes for Malignant Cylindroma

Drugs & Therapeutics for Malignant Cylindroma

Search Clinical Trials , NIH Clinical Center for Malignant Cylindroma

Genetic Tests for Malignant Cylindroma

Anatomical Context for Malignant Cylindroma

MalaCards organs/tissues related to Malignant Cylindroma:

42
Bone

Publications for Malignant Cylindroma

Articles related to Malignant Cylindroma:

(show all 12)
# Title Authors Year
1
Malignant cylindroma in a patient with Brooke-Spiegler syndrome. ( 26114054 )
2015
2
Malignant Cylindroma of Post Aural Region Involving the Temporal Bone. ( 26393151 )
2015
3
Malignant cylindroma arising as a solitary neck lesion. ( 24751615 )
2014
4
Well-differentiated malignant cylindroma. ( 22814325 )
2012
5
Malignant cylindroma of the scalp arising in a setting of multiple cylindromatosis: a case report. ( 20596852 )
2009
6
Malignant cylindroma of the external auditory canal. ( 16371854 )
2006
7
Distinct expression patterns of alpha1 (IV) and alpha5 (IV) collagen chains in cylindroma and malignant cylindroma. ( 15583824 )
2005
8
Malignant cylindroma in Brooke-Spiegler syndrome. ( 11096200 )
2000
9
Well-differentiated malignant cylindroma. ( 8721602 )
1996
10
Well-differentiated malignant cylindroma with partially preserved hyaline sheaths. A locally invasive neoplasm? ( 8600783 )
1995
11
Malignant cylindroma of the scalp. ( 1661755 )
1991
12
Adenoid cystic carcinoma of the vulva. Malignant cylindroma. ( 200878 )
1978

Variations for Malignant Cylindroma

Expression for Malignant Cylindroma

Search GEO for disease gene expression data for Malignant Cylindroma.

Pathways for Malignant Cylindroma

Pathways related to Malignant Cylindroma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 COL4A1 COL4A5
2
Show member pathways
12.44 COL4A1 COL4A5
3
Show member pathways
12.39 COL4A1 COL4A5
4
Show member pathways
12.31 COL4A1 COL4A5
5 12.23 COL4A1 COL4A5
6
Show member pathways
12.22 COL4A1 COL4A5
7
Show member pathways
12.13 COL4A1 COL4A5
8
Show member pathways
12.01 COL4A1 COL4A5
9
Show member pathways
11.64 COL4A1 COL4A5
10
Show member pathways
11.62 COL4A1 COL4A5
11 11.4 COL4A1 COL4A5
12 11.35 COL4A1 COL4A5
13 11.29 COL4A1 COL4A5
14 11.04 COL4A1 COL4A5
15 10.85 COL4A1 COL4A5
16 10.56 COL4A1 COL4A5
17 10.43 COL4A1 COL4A5
18 10.19 COL4A1 COL4A5

GO Terms for Malignant Cylindroma

Cellular components related to Malignant Cylindroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.37 COL4A1 COL4A5
2 endoplasmic reticulum lumen GO:0005788 9.32 COL4A1 COL4A5
3 collagen-containing extracellular matrix GO:0062023 9.26 COL4A1 COL4A5
4 basement membrane GO:0005604 9.16 COL4A1 COL4A5
5 collagen trimer GO:0005581 8.96 COL4A1 COL4A5
6 collagen type IV trimer GO:0005587 8.62 COL4A1 COL4A5

Biological processes related to Malignant Cylindroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.16 COL4A1 COL4A5
2 neuromuscular junction development GO:0007528 8.96 COL4A1 COL4A5
3 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 8.62 COL4A1 COL4A5

Molecular functions related to Malignant Cylindroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.96 COL4A1 COL4A5
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL4A1 COL4A5

Sources for Malignant Cylindroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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