MCID: MLG087
MIFTS: 20

Malignant Cylindroma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Malignant Cylindroma

MalaCards integrated aliases for Malignant Cylindroma:

Name: Malignant Cylindroma 20 70

Classifications:



External Ids:

UMLS 70 C1275214

Summaries for Malignant Cylindroma

MalaCards based summary : Malignant Cylindroma is related to brooke-spiegler syndrome and spiradenoma. An important gene associated with Malignant Cylindroma is COL4A1 (Collagen Type IV Alpha 1 Chain), and among its related pathways/superpathways are Circadian entrainment and PI3K-Akt signaling pathway. Affiliated tissues include kidney and trachea.

Related Diseases for Malignant Cylindroma

Diseases related to Malignant Cylindroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 brooke-spiegler syndrome 10.1
2 spiradenoma 10.1
3 adenoid cystic carcinoma 9.9
4 rare tumor 9.9
5 x-linked alport syndrome 9.7 COL4A5 COL4A1
6 alport syndrome 9.7 COL4A5 COL4A1
7 autosomal dominant alport syndrome 9.7 COL4A5 COL4A1
8 autosomal recessive alport syndrome 9.7 COL4A5 COL4A1
9 porencephaly 9.7 COL4A5 COL4A1
10 hematuria, benign familial 9.6 COL4A5 COL4A1
11 polycystic kidney disease 9.6 COL4A5 COL4A1
12 kidney disease 9.5 COL4A5 COL4A1

Graphical network of the top 20 diseases related to Malignant Cylindroma:



Diseases related to Malignant Cylindroma

Symptoms & Phenotypes for Malignant Cylindroma

Drugs & Therapeutics for Malignant Cylindroma

Search Clinical Trials , NIH Clinical Center for Malignant Cylindroma

Genetic Tests for Malignant Cylindroma

Anatomical Context for Malignant Cylindroma

MalaCards organs/tissues related to Malignant Cylindroma:

40
Kidney, Trachea

Publications for Malignant Cylindroma

Articles related to Malignant Cylindroma:

(show all 26)
# Title Authors PMID Year
1
Surgical Treatment of Brooke-Spiegler Syndrome. 61
33177425 2020
2
Malignant cylindroma of the scalp treated with staged perimeter excision: A case report and literature review. 61
32158878 2019
3
A case series on the conservative management of the bony skull in patients with aggressive skin carcinomas of the scalp. 61
30555672 2018
4
Malignant Cylindroma of Post Aural Region Involving the Temporal Bone. 61
26393151 2015
5
Malignant cylindroma in a patient with Brooke-Spiegler syndrome. 61
26114054 2015
6
Cylindroma: an update. 61
25515269 2015
7
Malignant cylindroma arising as a solitary neck lesion. 61
24751615 2014
8
Perilipin and adipophilin expression in sebaceous carcinoma and mimics. 61
23642680 2013
9
Well-differentiated malignant cylindroma. 61
22814325 2012
10
Solitary cylindroma with malignant transformation. 61
22615516 2012
11
Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses. 61
23056620 2012
12
Malignant cylindroma of the scalp arising in a setting of multiple cylindromatosis: a case report. 61
20596852 2009
13
Malignant cylindroma of the external auditory canal. 61
16371854 2006
14
Distinct expression patterns of alpha1 (IV) and alpha5 (IV) collagen chains in cylindroma and malignant cylindroma. 61
15583824 2005
15
A novel epidermal nevus syndrome with congenital cylindromatous turban tumor. 61
14507410 2003
16
[Malignant cylindroma]. 61
11076301 2000
17
Malignant cylindroma in Brooke-Spiegler syndrome. 61
11096200 2000
18
HPV positive bronchopulmonary carcinomas in women with previous high-grade cervical intraepithelial neoplasia (CIN III). 61
10427955 1999
19
Well-differentiated malignant cylindroma. 61
8721602 1996
20
p53 expression in sweat gland tumors. 61
8705267 1996
21
Well-differentiated malignant cylindroma with partially preserved hyaline sheaths. A locally invasive neoplasm? 61
8600783 1995
22
Cutaneous cylindroma with malignant transformation. 61
7688655 1993
23
Malignant cylindroma of the scalp. 61
1661755 1991
24
[Malignant cylindroma]. 61
221278 1979
25
Adenoid cystic carcinoma of the vulva. Malignant cylindroma. 61
200878 1978
26
[Malignant cylindroma of the trachea]. 61
13747861 1961

Variations for Malignant Cylindroma

Expression for Malignant Cylindroma

Search GEO for disease gene expression data for Malignant Cylindroma.

Pathways for Malignant Cylindroma

Pathways related to Malignant Cylindroma according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.42 COL4A5 COL4A1
2
Show member pathways
12.38 COL4A5 COL4A1
3
Show member pathways
12.3 COL4A5 COL4A1
4
Show member pathways
12.24 COL4A5 COL4A1
5 12.22 COL4A5 COL4A1
6
Show member pathways
12.13 COL4A5 COL4A1
7
Show member pathways
12.01 COL4A5 COL4A1
8
Show member pathways
11.63 COL4A5 COL4A1
9 11.41 COL4A5 COL4A1
10 11.37 COL4A5 COL4A1
11 11.29 COL4A5 COL4A1
12 11.04 COL4A5 COL4A1
13 10.85 COL4A5 COL4A1
14 10.56 COL4A5 COL4A1
15 10.43 COL4A5 COL4A1
16 10.19 COL4A5 COL4A1

GO Terms for Malignant Cylindroma

Cellular components related to Malignant Cylindroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.37 COL4A5 COL4A1
2 endoplasmic reticulum lumen GO:0005788 9.32 COL4A5 COL4A1
3 extracellular matrix GO:0031012 9.26 COL4A5 COL4A1
4 basement membrane GO:0005604 9.16 COL4A5 COL4A1
5 collagen trimer GO:0005581 8.96 COL4A5 COL4A1
6 collagen type IV trimer GO:0005587 8.62 COL4A5 COL4A1

Biological processes related to Malignant Cylindroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.16 COL4A5 COL4A1
2 neuromuscular junction development GO:0007528 8.96 COL4A5 COL4A1
3 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 8.62 COL4A5 COL4A1

Molecular functions related to Malignant Cylindroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.96 COL4A5 COL4A1
2 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.62 COL4A5 COL4A1

Sources for Malignant Cylindroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....