MCID: MLG063
MIFTS: 26

Malignant Dermis Tumor

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Malignant Dermis Tumor

MalaCards integrated aliases for Malignant Dermis Tumor:

Name: Malignant Dermis Tumor 12 15
Malignant Tumor of Dermis 12 70
Malignant Neoplasm of Dermis 12
Malignant Tumour of Dermis 12
Malignant Dermis Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5274
NCIt 50 C4574
SNOMED-CT 67 255096006
UMLS 70 C0346811

Summaries for Malignant Dermis Tumor

MalaCards based summary : Malignant Dermis Tumor, also known as malignant tumor of dermis, is related to sensory organ benign neoplasm and benign perivascular tumor. An important gene associated with Malignant Dermis Tumor is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Toll-like Receptor Signaling Pathway. Related phenotypes are craniofacial and integument

Related Diseases for Malignant Dermis Tumor

Diseases in the Dermis Tumor family:

Malignant Dermis Tumor

Diseases related to Malignant Dermis Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 sensory organ benign neoplasm 10.2 NRAS MLANA
2 benign perivascular tumor 10.2 MLANA KIT
3 perivascular tumor 10.2 MLANA KIT
4 small intestine leiomyoma 10.2 MLANA KIT
5 skin sarcoma 10.2 MLANA KIT
6 mucinous stomach adenocarcinoma 10.2 MLANA KIT
7 retroperitoneal sarcoma 10.2 MLANA KIT
8 glomangiomatosis 10.2 MLANA KIT
9 vagina sarcoma 10.2 MLANA KIT
10 thymus clear cell carcinoma 10.2 MLANA KIT
11 uterus leiomyosarcoma 10.2 MLANA KIT
12 uterine corpus sarcoma 10.2 MLANA KIT
13 epithelioid cell melanoma 10.2 MLANA GNA11
14 retroperitoneum carcinoma 10.2 MLANA KIT
15 bladder sarcoma 10.2 MLANA KIT
16 acneiform dermatitis 10.2 NRAS HRAS
17 kidney benign neoplasm 10.2 MLANA KIT
18 perivascular epithelioid cell tumor 10.1 MLANA KIT
19 oculoectodermal syndrome 10.1 NRAS HRAS
20 large intestine adenocarcinoma 10.1 NRAS HRAS
21 benign struma ovarii 10.1 NRAS HRAS
22 melanocytic nevus syndrome, congenital 10.1 NRAS HRAS
23 nasal cavity adenocarcinoma 10.1 MLANA HRAS
24 nasal cavity cancer 10.1 MLANA HRAS
25 conjunctival pigmentation 10.1 MLANA IFNA2
26 anus cancer 10.1 KIT HRAS
27 amelanotic melanoma 10.1 MLANA KIT
28 uterine body mixed cancer 10.1 KIT HRAS
29 spermatocytoma 10.1 KIT HRAS
30 mixed cell type cancer 10.0 KIT HRAS
31 ras-associated autoimmune leukoproliferative disorder 10.0 NRAS HRAS
32 mesenchymal cell neoplasm 10.0 MLANA KIT
33 sarcomatoid renal cell carcinoma 10.0 KIT IFNA2
34 respiratory system benign neoplasm 10.0 MLANA HRAS
35 connective tissue benign neoplasm 10.0 MLANA KIT
36 core binding factor acute myeloid leukemia 10.0 NRAS KIT HRAS
37 vulvar disease 10.0 NRAS KIT HRAS
38 acral lentiginous melanoma 10.0 NRAS KIT HRAS
39 myelodysplastic/myeloproliferative neoplasm 10.0 NRAS KIT HRAS
40 childhood acute myeloid leukemia 10.0 NRAS KIT HRAS
41 thyroid gland follicular carcinoma 10.0 NRAS KIT HRAS
42 thyroid gland anaplastic carcinoma 10.0 NRAS KIT HRAS
43 neurofibromatosis, type i 10.0 NRAS KIT HRAS
44 phakomatosis cesioflammea 10.0 GNAQ GNA11
45 integumentary system disease 9.9 NRAS KIT HRAS
46 renal cell carcinoma, papillary, 1 9.9 NRAS KIT HRAS
47 muscle cancer 9.9 MLANA KIT HRAS
48 bone marrow cancer 9.9 NRAS KIT HRAS
49 gastric adenocarcinoma 9.9 NRAS KIT HRAS
50 hypocalciuric hypercalcemia, familial, type ii 9.9 GNAQ GNA11

Graphical network of the top 20 diseases related to Malignant Dermis Tumor:



Diseases related to Malignant Dermis Tumor

Symptoms & Phenotypes for Malignant Dermis Tumor

MGI Mouse Phenotypes related to Malignant Dermis Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.55 GNA11 GNAQ HRAS KIT NRAS
2 integument MP:0010771 9.43 GNA11 GNAQ HRAS KIT MLANA NRAS
3 pigmentation MP:0001186 9.02 GNA11 GNAQ KIT MLANA NRAS

Drugs & Therapeutics for Malignant Dermis Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Dermis Tumor

Genetic Tests for Malignant Dermis Tumor

Anatomical Context for Malignant Dermis Tumor

Publications for Malignant Dermis Tumor

Articles related to Malignant Dermis Tumor:

# Title Authors PMID Year
1
Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases. 61
20123452 2010

Variations for Malignant Dermis Tumor

Expression for Malignant Dermis Tumor

Search GEO for disease gene expression data for Malignant Dermis Tumor.

Pathways for Malignant Dermis Tumor

Pathways related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.12 NRAS IFNA2 HRAS GNAQ GNA11
2
Show member pathways
13 NRAS IFNA2 HRAS GNAQ GNA11
3
Show member pathways
12.91 NRAS HRAS GNAQ GNA11
4
Show member pathways
12.89 NRAS KIT HRAS GNA11
5
Show member pathways
12.88 NRAS KIT HRAS GNA11
6
Show member pathways
12.81 NRAS KIT IFNA2 HRAS
7
Show member pathways
12.71 NRAS HRAS GNAQ GNA11
8
Show member pathways
12.65 NRAS IFNA2 HRAS GNAQ GNA11
9
Show member pathways
12.61 NRAS HRAS GNAQ GNA11
10
Show member pathways
12.6 NRAS KIT HRAS GNAQ GNA11
11
Show member pathways
12.57 NRAS KIT HRAS GNAQ
12
Show member pathways
12.53 NRAS KIT HRAS GNAQ GNA11
13
Show member pathways
12.46 NRAS HRAS GNAQ GNA11
14
Show member pathways
12.42 NRAS HRAS GNAQ GNA11
15 12.36 NRAS KIT IFNA2 HRAS GNAQ GNA11
16
Show member pathways
12.27 NRAS HRAS GNAQ GNA11
17
Show member pathways
12.25 NRAS KIT HRAS
18
Show member pathways
12.17 HRAS GNAQ GNA11
19 11.94 NRAS HRAS GNAQ
20
Show member pathways
11.88 HRAS GNAQ GNA11
21
Show member pathways
11.86 HRAS GNAQ GNA11
22 11.84 NRAS HRAS GNAQ
23 11.82 NRAS HRAS GNAQ
24
Show member pathways
11.82 NRAS HRAS GNAQ GNA11
25 11.81 NRAS HRAS GNAQ
26
Show member pathways
11.77 NRAS HRAS GNAQ
27
Show member pathways
11.64 NRAS KIT HRAS
28 11.52 NRAS HRAS GNAQ GNA11
29 11.52 NRAS KIT HRAS
30 11.5 NRAS HRAS GNAQ GNA11
31 11.47 HRAS GNAQ GNA11
32 11.33 NRAS HRAS
33 11.29 GNAQ GNA11
34 11.27 NRAS HRAS
35 11.23 GNAQ GNA11
36 11.21 GNAQ GNA11
37 11.2 NRAS HRAS
38 11.15 NRAS HRAS
39 11.15 NRAS HRAS
40
Show member pathways
11.13 NRAS HRAS
41
Show member pathways
11.07 NRAS HRAS
42 11.06 NRAS HRAS GNAQ GNA11
43 11.02 NRAS HRAS
44 10.99 NRAS HRAS
45
Show member pathways
10.84 GNAQ GNA11
46 10.8 NRAS HRAS GNAQ
47 10.73 NRAS HRAS
48 10.7 NRAS HRAS GNAQ GNA11

GO Terms for Malignant Dermis Tumor

Cellular components related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heterotrimeric G-protein complex GO:0005834 8.62 GNAQ GNA11

Biological processes related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.85 NRAS KIT HRAS GPHA2 GNAQ GNA11
2 MAPK cascade GO:0000165 9.61 NRAS KIT HRAS
3 action potential GO:0001508 9.4 GNAQ GNA11
4 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.32 GNAQ GNA11
5 positive regulation of phospholipase C activity GO:0010863 9.26 KIT HRAS
6 developmental pigmentation GO:0048066 9.16 KIT GNA11
7 phototransduction, visible light GO:0007603 8.96 GNAQ GNA11
8 entrainment of circadian clock GO:0009649 8.62 GNAQ GNA11

Molecular functions related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 NRAS HRAS GNAQ GNA11
2 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNAQ GNA11
3 guanyl nucleotide binding GO:0019001 9.26 GNAQ GNA11
4 GTPase activity GO:0003924 9.26 NRAS HRAS GNAQ GNA11
5 type 2A serotonin receptor binding GO:0031826 8.62 GNAQ GNA11

Sources for Malignant Dermis Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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