MCID: MLG063
MIFTS: 32

Malignant Dermis Tumor

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Malignant Dermis Tumor

MalaCards integrated aliases for Malignant Dermis Tumor:

Name: Malignant Dermis Tumor 12 15
Malignant Tumor of Dermis 12 73
Malignant Neoplasm of Dermis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5274
NCIt 50 C4574
UMLS 73 C0346811

Summaries for Malignant Dermis Tumor

MalaCards based summary : Malignant Dermis Tumor, also known as malignant tumor of dermis, is related to giant congenital nevus and thymoma, familial. An important gene associated with Malignant Dermis Tumor is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cytokine Signaling in Immune system. Affiliated tissues include skin, bone and lung, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Malignant Dermis Tumor

Diseases in the Dermis Tumor family:

Malignant Dermis Tumor

Diseases related to Malignant Dermis Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 76)
# Related Disease Score Top Affiliating Genes
1 giant congenital nevus 10.2 HRAS NRAS
2 thymoma, familial 10.2 HRAS KIT
3 liver leiomyosarcoma 10.2 CHGA SMUG1
4 conventional fibrosarcoma 10.2 KIT NRAS
5 malignant spindle cell melanoma 10.2 KIT NRAS TYR
6 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS NRAS
7 cellular ependymoma 10.2 CHGA SMUG1
8 rectosigmoid junction neoplasm 10.2 KCNJ11 SMUG1
9 gastrointestinal neuroendocrine tumor 10.2 CHGA SMUG1
10 melanomatosis 10.2 HRAS NRAS
11 uterine inversion 10.2 F7 KCNJ11 KIT
12 core binding factor acute myeloid leukemia 10.2 HRAS KIT NRAS
13 aggressive digital papillary adenocarcinoma 10.2 HRAS KIT
14 malignant conjunctival melanoma 10.2 HRAS IFNA2 NRAS
15 benign struma ovarii 10.2 HRAS NRAS SMUG1
16 cutaneous ganglioneuroma 10.2 KIT NCAM1
17 melanocytic nevus syndrome, congenital 10.2 HRAS NRAS TYR
18 renal cell carcinoma, papillary, 1 10.2 HRAS KIT NRAS
19 olfactory groove meningioma 10.2 CHGA F7
20 thymic epithelial tumor 10.1 CD99 KIT
21 gastrointestinal system cancer 10.1 HRAS KIT SMUG1
22 inherited blood coagulation disease 10.1 F7 F9 ITGA2B
23 blood coagulation disease 10.1 F7 F9 ITGA2B
24 secondary hypertrophic osteoarthropathy 10.1 HRAS KCNJ11 SMUG1
25 marcus gunn phenomenon 10.1 HRAS NRAS
26 esophageal neuroendocrine tumor 10.1 CHGA NCAM1
27 hemorrhagic disease 10.1 F7 F9 ITGA2B
28 apocrine adenoma 10.1 HRAS UBC
29 ovarian large-cell neuroendocrine carcinoma 10.1 CHGA NCAM1
30 mediastinal cancer 10.1 KIT NCAM1 SMUG1
31 cecum adenocarcinoma 10.1 CHGA HRAS SMUG1
32 gastrointestinal system disease 10.1 HRAS KIT SMUG1
33 leukocyte disease 10.1 KIT NCAM1 SMUG1
34 melanoma, cutaneous malignant 1 10.1 HRAS IFNA2 KIT NRAS
35 conjunctival cancer 10.1 IFNA2 NRAS
36 transitional meningioma 10.1 HIF1A NCAM1
37 leukemia, chronic myeloid 10.1 HRAS IFNA2 KIT NRAS
38 thymoma 10.1 CTLA4 HRAS KIT
39 intracranial primitive neuroectodermal tumor 10.1 CD99 CHGA
40 endocrine gland cancer 10.1 CHGA HRAS SMUG1
41 small cell carcinoma 10.1 CHGA KIT NCAM1
42 connective tissue cancer 10.1 CD99 KIT SMUG1
43 malignant anus melanoma 10.1 KIT MLANA
44 large cell neuroendocrine carcinoma 10.1 CHGA KIT NCAM1
45 gallbladder small cell carcinoma 10.0 CHGA NCAM1 SMUG1
46 halo nevi 10.0 MLANA TYR
47 merkel cell carcinoma 10.0 CHGA KIT NCAM1
48 brain sarcoma 10.0 MLANA SMUG1
49 parasitic ichthyosporea infectious disease 10.0 NCAM1 UBC
50 thyroid cancer, nonmedullary, 2 10.0 CHGA HRAS NRAS SMUG1

Graphical network of the top 20 diseases related to Malignant Dermis Tumor:



Diseases related to Malignant Dermis Tumor

Symptoms & Phenotypes for Malignant Dermis Tumor

GenomeRNAi Phenotypes related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CHGA F9 HRAS ITGA2B KCNJ11 NCAM1

MGI Mouse Phenotypes related to Malignant Dermis Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.18 CHGA CTLA4 F7 F9 HIF1A HRAS
2 cardiovascular system MP:0005385 10.17 CHGA CTLA4 F7 F9 HIF1A HRAS
3 mortality/aging MP:0010768 10.07 CHGA CTLA4 F7 F9 HIF1A HRAS
4 endocrine/exocrine gland MP:0005379 10.01 CHGA CTLA4 HIF1A HRAS KCNJ11 KIT
5 integument MP:0010771 9.92 CTLA4 HIF1A HRAS KCNJ11 KIT MLANA
6 neoplasm MP:0002006 9.7 HIF1A HRAS KIT NRAS NUDT1 SMUG1
7 no phenotypic analysis MP:0003012 9.56 CHGA F7 HRAS KCNJ11 KIT MLANA
8 pigmentation MP:0001186 9.1 CTLA4 KCNJ11 KIT MLANA NRAS TYR

Drugs & Therapeutics for Malignant Dermis Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Dermis Tumor

Genetic Tests for Malignant Dermis Tumor

Anatomical Context for Malignant Dermis Tumor

MalaCards organs/tissues related to Malignant Dermis Tumor:

41
Skin, Bone, Lung, Brain, Heart, Myeloid, Bone Marrow

Publications for Malignant Dermis Tumor

Variations for Malignant Dermis Tumor

Expression for Malignant Dermis Tumor

Search GEO for disease gene expression data for Malignant Dermis Tumor.

Pathways for Malignant Dermis Tumor

Pathways related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 CD99 F7 F9 HRAS IFNA2 ITGA2B
2
Show member pathways
12.67 HIF1A HRAS IFNA2 ITGA2B KIT NCAM1
3 12.38 CTLA4 KIT MLANA NCAM1
4 12.35 HIF1A HRAS IFNA2 ITGA2B KIT NRAS
5
Show member pathways
12.22 HRAS KIT NRAS TYR
6
Show member pathways
12.17 HIF1A HRAS KIT NRAS
7 11.82 HIF1A HRAS NRAS
8
Show member pathways
11.77 HRAS NRAS UBC
9
Show member pathways
11.74 HIF1A HRAS NRAS UBC
10
Show member pathways
11.66 HRAS NRAS UBC
11 11.62 IFNA2 ITGA2B KIT NCAM1
12
Show member pathways
11.59 HRAS KIT NRAS
13 11.5 IFNA2 KIT NCAM1
14 11.42 HIF1A HRAS NRAS
15
Show member pathways
11.39 HRAS NRAS UBC
16 10.74 HIF1A HRAS KIT NRAS
17 10.72 F7 F9
18 10.65 HRAS NRAS

GO Terms for Malignant Dermis Tumor

Cellular components related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.4 CD99 CTLA4 F7 F9 HRAS ITGA2B
2 acrosomal vesicle GO:0001669 9.13 KCNJ11 KIT NUDT1

Biological processes related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.62 HIF1A IFNA2 KIT UBC
2 MAPK cascade GO:0000165 9.46 HRAS KIT NCAM1 NRAS
3 embryonic hemopoiesis GO:0035162 9.4 HIF1A KIT
4 mast cell degranulation GO:0043303 9.37 CHGA KIT
5 positive regulation of phospholipase C activity GO:0010863 9.26 HRAS KIT
6 mast cell chemotaxis GO:0002551 8.96 CHGA KIT
7 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 CD99 CTLA4 F7 F9 HIF1A HRAS

Sources for Malignant Dermis Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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