MCID: MLG063
MIFTS: 28

Malignant Dermis Tumor

Categories: Cancer diseases

Aliases & Classifications for Malignant Dermis Tumor

MalaCards integrated aliases for Malignant Dermis Tumor:

Name: Malignant Dermis Tumor 12 15
Malignant Tumor of Dermis 12 73
Malignant Neoplasm of Dermis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5274
NCIt 50 C4574
SNOMED-CT 68 255096006
UMLS 73 C0346811

Summaries for Malignant Dermis Tumor

MalaCards based summary : Malignant Dermis Tumor, also known as malignant tumor of dermis, is related to thymoma, familial and giant congenital nevus. An important gene associated with Malignant Dermis Tumor is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cytokine Signaling in Immune system. Related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Malignant Dermis Tumor

Diseases in the Dermis Tumor family:

Malignant Dermis Tumor

Diseases related to Malignant Dermis Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 thymoma, familial 10.9 HRAS KIT
2 giant congenital nevus 10.9 HRAS NRAS
3 liver leiomyosarcoma 10.8 CHGA SMUG1
4 schimmelpenning-feuerstein-mims syndrome 10.8 HRAS NRAS
5 malignant spindle cell melanoma 10.8 KIT NRAS TYR
6 cellular ependymoma 10.7 CHGA SMUG1
7 malignant conjunctival melanoma 10.7 HRAS IFNA2 NRAS
8 core binding factor acute myeloid leukemia 10.7 HRAS KIT NRAS
9 gastrointestinal neuroendocrine tumor 10.7 CHGA SMUG1
10 benign struma ovarii 10.7 HRAS NRAS SMUG1
11 rectosigmoid junction neoplasm 10.7 KCNJ11 SMUG1
12 melanocytic nevus syndrome, congenital 10.6 HRAS NRAS TYR
13 melanomatosis 10.6 HRAS NRAS
14 aggressive digital papillary adenocarcinoma 10.6 HRAS KIT
15 renal cell carcinoma, papillary, 1 10.6 HRAS KIT NRAS
16 uterine inversion 10.6 F7 KCNJ11 KIT
17 olfactory groove meningioma 10.6 CHGA F7
18 melanoma, cutaneous malignant 1 10.6 HRAS IFNA2 NRAS
19 cutaneous ganglioneuroma 10.6 KIT NCAM1
20 marcus gunn phenomenon 10.6 HRAS NRAS
21 gastrointestinal system cancer 10.6 HRAS KIT SMUG1
22 pulmonary artery leiomyosarcoma 10.6 HBA1 SMUG1
23 spleen angiosarcoma 10.5 HBA1 SMUG1
24 bone epithelioid hemangioma 10.5 HBA1 SMUG1
25 esophageal neuroendocrine tumor 10.5 CHGA NCAM1
26 sarcomatoid renal cell carcinoma 10.5 IFNA2 KIT
27 inherited blood coagulation disease 10.5 F7 F9 ITGA2B
28 thymic epithelial tumor 10.5 CD99 KIT
29 blood coagulation disease 10.5 F7 F9 ITGA2B
30 ovarian large-cell neuroendocrine carcinoma 10.5 CHGA NCAM1
31 apocrine adenoma 10.5 HRAS UBC
32 cecum adenocarcinoma 10.5 CHGA HRAS SMUG1
33 mediastinal cancer 10.5 KIT NCAM1 SMUG1
34 adenosquamous pancreas carcinoma 10.5 HIF1A HRAS IFNA2
35 hemorrhagic disease 10.5 F7 F9 ITGA2B
36 hemangioma of liver 10.4 HBA1 IFNA2
37 endocrine gland cancer 10.4 CHGA HRAS SMUG1
38 thyroid sarcoma 10.4 HBA1 KCNJ11
39 extraosseous osteosarcoma 10.4 HBA1 SMUG1
40 leukemia, chronic myeloid 10.4 HRAS IFNA2 KIT NRAS
41 thymoma 10.4 CTLA4 HRAS KIT
42 heart cancer 10.3 HBA1 SMUG1
43 conjunctival cancer 10.3 IFNA2 NRAS
44 gallbladder small cell carcinoma 10.3 CHGA NCAM1 SMUG1
45 large cell neuroendocrine carcinoma 10.3 CHGA KIT NCAM1
46 intracranial primitive neuroectodermal tumor 10.3 CD99 CHGA
47 liver angiosarcoma 10.3 HBA1 HRAS NRAS
48 autoimmune lymphoproliferative syndrome 10.3 CTLA4 HRAS NRAS
49 transitional meningioma 10.3 HIF1A NCAM1
50 small cell carcinoma 10.3 CHGA KIT NCAM1

Graphical network of the top 20 diseases related to Malignant Dermis Tumor:



Diseases related to Malignant Dermis Tumor

Symptoms & Phenotypes for Malignant Dermis Tumor

GenomeRNAi Phenotypes related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CHGA F9 HRAS ITGA2B KCNJ11 NCAM1

MGI Mouse Phenotypes related to Malignant Dermis Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.17 F7 KIT F9 HIF1A NRAS HRAS
2 homeostasis/metabolism MP:0005376 10.15 CTLA4 KCNJ11 F7 KIT F9 HIF1A
3 mortality/aging MP:0010768 10.07 KCNJ11 F7 KIT F9 HIF1A NCAM1
4 endocrine/exocrine gland MP:0005379 10.01 CTLA4 KCNJ11 KIT HIF1A HRAS CHGA
5 integument MP:0010771 9.92 CTLA4 KCNJ11 KIT HIF1A MLANA HRAS
6 neoplasm MP:0002006 9.63 KIT HIF1A HRAS TYR NRAS SMUG1
7 no phenotypic analysis MP:0003012 9.56 F7 KIT MLANA HRAS NRAS CHGA
8 pigmentation MP:0001186 9.1 KIT MLANA NRAS KCNJ11 CTLA4 TYR

Drugs & Therapeutics for Malignant Dermis Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Dermis Tumor

Genetic Tests for Malignant Dermis Tumor

Anatomical Context for Malignant Dermis Tumor

Publications for Malignant Dermis Tumor

Variations for Malignant Dermis Tumor

Expression for Malignant Dermis Tumor

Search GEO for disease gene expression data for Malignant Dermis Tumor.

Pathways for Malignant Dermis Tumor

Pathways related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.99 CD99 F7 F9 HRAS IFNA2 ITGA2B
2
Show member pathways
12.87 HIF1A HRAS IFNA2 ITGA2B KIT NCAM1
3 12.37 CTLA4 KIT MLANA NCAM1
4
Show member pathways
12.17 HIF1A HRAS KIT NRAS
5 12.15 HIF1A HRAS IFNA2 ITGA2B KIT NRAS
6 11.81 HIF1A HRAS NRAS
7
Show member pathways
11.76 HRAS NRAS UBC
8
Show member pathways
11.74 HIF1A HRAS NRAS UBC
9
Show member pathways
11.65 HRAS NRAS UBC
10 11.62 IFNA2 ITGA2B KIT NCAM1
11
Show member pathways
11.59 HRAS KIT NRAS
12 11.5 IFNA2 KIT NCAM1
13 11.42 HIF1A HRAS NRAS
14
Show member pathways
11.39 HRAS NRAS UBC
15 10.74 HIF1A HRAS KIT NRAS
16 10.71 F7 F9
17 10.64 HRAS NRAS

GO Terms for Malignant Dermis Tumor

Cellular components related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CTLA4 ITGA2B KIT NCAM1

Biological processes related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.76 HIF1A IFNA2 KIT UBC
2 embryonic hemopoiesis GO:0035162 9.43 HIF1A KIT
3 mast cell degranulation GO:0043303 9.4 CHGA KIT
4 peptidyl-glutamic acid carboxylation GO:0017187 9.37 F7 F9
5 MAPK cascade GO:0000165 9.35 HRAS KIT NCAM1 NRAS UBC
6 ERBB2 signaling pathway GO:0038128 9.33 HRAS NRAS UBC
7 blood coagulation, extrinsic pathway GO:0007598 9.32 F7 F9
8 mast cell chemotaxis GO:0002551 9.26 CHGA KIT
9 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Malignant Dermis Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.55 CD99 CTLA4 F7 F9 HBA1 HIF1A

Sources for Malignant Dermis Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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