MCID: MLG133
MIFTS: 31

Malignant Ectomesenchymoma

Categories: Rare diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Malignant Ectomesenchymoma

MalaCards integrated aliases for Malignant Ectomesenchymoma:

Name: Malignant Ectomesenchymoma 53
Rhabdomyosarcoma with Ganglionic Differentiation 73
Ectomesenchymoma 53

Classifications:



Summaries for Malignant Ectomesenchymoma

MalaCards based summary : Malignant Ectomesenchymoma, also known as rhabdomyosarcoma with ganglionic differentiation, is related to ectomesenchymoma and embryonal rhabdomyosarcoma. An important gene associated with Malignant Ectomesenchymoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Immune response IL-2 activation and signaling pathway and Senescence and Autophagy in Cancer. The drugs Lenograstim and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include kidney and lung.

Wikipedia : 76 Malignant ectomesenchymoma is a rare, fast-growing tumor of the nervous system or soft tissue that... more...

Related Diseases for Malignant Ectomesenchymoma

Diseases in the Ectomesenchymoma family:

Malignant Ectomesenchymoma

Diseases related to Malignant Ectomesenchymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 ectomesenchymoma 29.4 DES ENO2 HMGA1 HMGA2 HRAS
2 embryonal rhabdomyosarcoma 29.4 DES HRAS
3 breast rhabdomyosarcoma 10.5 DES ENO2
4 primitive neuroectodermal tumor of the cervix uteri 10.5 DES ENO2
5 epulis 10.4 DES ENO2
6 ossifying fibromyxoid tumor 10.4 DES ENO2
7 epithelioid leiomyosarcoma 10.4 DES ENO2
8 desmoplastic small round cell tumor 10.4 DES ENO2
9 extraskeletal ewing sarcoma 10.4 DES ENO2
10 glomus tumor 10.4 DES ENO2
11 granular cell tumor 10.4 DES ENO2
12 congenital epulis 10.4 DES ENO2
13 papillary tumor of the pineal region 10.4 ENO2 S100A1
14 medullomyoblastoma 10.4 DES ENO2
15 spindle cell carcinoma 10.3 DES ENO2
16 chondroid chordoma 10.3 ENO2 S100A1
17 muscle cancer 10.3 DES ENO2
18 ischemic fasciitis 10.3 DES S100A1
19 reticulum cell sarcoma 10.3 DES S100A1
20 neurilemmoma 10.3 DES ENO2
21 pericardial mesothelioma 10.3 ENO2 S100A1
22 angiomyoma 10.2 ENO2 HMGA2
23 alveolar soft part sarcoma 10.2 DES ENO2
24 chondromyxoid fibroma 10.2 DES S100A1
25 rhabdomyosarcoma 2 10.2 DES ENO2
26 mesenchymoma 10.2 DES HMGA2
27 dedifferentiated liposarcoma 10.2 DES HMGA2
28 ring chromosome 1 10.1 HMGA1 HMGA2
29 pelvic lipomatosis 10.1 HMGA1 HMGA2
30 smooth muscle tumor 10.1 DES HMGA2
31 rhabdomyosarcoma 10.1
32 chordoma 10.0 DES S100A1
33 atypical teratoid rhabdoid tumor 10.0 DES HMGA2
34 sinusitis 10.0
35 meningeal melanomatosis 10.0 ENO2 HRAS
36 mixed cell type cancer 10.0 ENO2 HRAS
37 adenosquamous cell lung carcinoma 10.0 ENO2 HRAS
38 malignant fibrous histiocytoma of bone 9.9 DES HRAS
39 duodenum cancer 9.9 ENO2 HRAS
40 liver angiosarcoma 9.9 ENO2 HRAS
41 sarcoma, synovial 9.9 DES HMGA2
42 central nervous system melanocytic neoplasm 9.9 ENO2 HRAS
43 liposarcoma 9.9 DES HMGA2
44 skin benign neoplasm 9.9 ENO2 HRAS
45 lung benign neoplasm 9.9 ENO2 HRAS
46 glomangioma 9.8 DES ENO2 S100A1
47 leiomyosarcoma 9.8 DES ENO2 S100A1
48 spindle cell sarcoma 9.8
49 fibrous histiocytoma 9.8
50 sarcoma 9.8

Graphical network of the top 20 diseases related to Malignant Ectomesenchymoma:



Diseases related to Malignant Ectomesenchymoma

Symptoms & Phenotypes for Malignant Ectomesenchymoma

Drugs & Therapeutics for Malignant Ectomesenchymoma

Drugs for Malignant Ectomesenchymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 3 135968-09-1
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
4
Mechlorethamine Approved, Investigational Phase 3 51-75-2 4033
5
Ifosfamide Approved Phase 3 3778-73-2 3690
6
Irinotecan Approved, Investigational Phase 3 97682-44-5, 100286-90-6 60838
7
Mesna Approved, Investigational Phase 3 3375-50-6 598
8
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
9
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
10
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
11
Camptothecin Experimental Phase 3 7689-03-4
12
Doxil Approved June 1999 Phase 3 31703
13
Isophosphamide mustard Phase 3 0
14 Alkylating Agents Phase 3
15 topoisomerase I inhibitors Phase 3
16 Adjuvants, Immunologic Phase 3
17 Topoisomerase Inhibitors Phase 3
18 Nucleic Acid Synthesis Inhibitors Phase 3
19 Anti-Bacterial Agents Phase 3
20 Antibiotics, Antitubercular Phase 3
21 Etoposide phosphate Phase 3
22 Immunosuppressive Agents Phase 3
23 Anti-Infective Agents Phase 3
24 Antirheumatic Agents Phase 3
25 Antimitotic Agents Phase 3
26 Antineoplastic Agents, Alkylating Phase 3
27 Antineoplastic Agents, Phytogenic Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 High-Dose Combination Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Metastatic Rhabdomyosarcoma or Ectomesenchymoma Active, not recruiting NCT00354744 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;irinotecan hydrochloride;vincristine sulfate

Search NIH Clinical Center for Malignant Ectomesenchymoma

Genetic Tests for Malignant Ectomesenchymoma

Anatomical Context for Malignant Ectomesenchymoma

MalaCards organs/tissues related to Malignant Ectomesenchymoma:

41
Kidney, Lung

Publications for Malignant Ectomesenchymoma

Articles related to Malignant Ectomesenchymoma:

(show all 29)
# Title Authors Year
1
Malignant Ectomesenchymoma: Series Analysis of a Histologically and Genetically Heterogeneous Tumor. ( 28994342 )
2017
2
Malignant Ectomesenchymoma: A Potential Pitfall of Diagnosis in the Spectrum of Pediatric Small Blue Round Cell Tumors. ( 28968263 )
2017
3
Frequent HRAS Mutations in Malignant Ectomesenchymoma: Overlapping Genetic Abnormalities With Embryonal Rhabdomyosarcoma. ( 26872011 )
2016
4
An Adult Paratesticular Malignant Ectomesenchymoma With Post-operative Flare-up of Lung Metastasis. ( 26793539 )
2015
5
Metastatic malignant ectomesenchymoma initially presenting as a pelvic mass: report of a case and review of literature. ( 25405050 )
2014
6
Malignant ectomesenchymoma in children and adolescents: report from the Cooperative Weichteilsarkom Studiengruppe (CWS). ( 22535600 )
2013
7
Malignant ectomesenchymoma of paranasal sinuses with proptosis and nodal involvement. ( 23174743 )
2012
8
Malignant ectomesenchymoma of the paranasal sinuses with proptosis. ( 22026142 )
2011
9
Malignant ectomesenchymoma of the nasal cavity. ( 22563163 )
2011
10
Malignant ectomesenchymoma of the nasal cavity. ( 17395109 )
2007
11
Malignant ectomesenchymoma: genetic profile reflects rhabdomyosarcomatous differentiation. ( 18043289 )
2007
12
Malignant ectomesenchymoma of the cerebrum. Case report and discussion of therapeutic options. ( 15747131 )
2005
13
A neonate with malignant ectomesenchymoma. ( 16363352 )
2005
14
Malignant ectomesenchymoma in the wrist of a child: case report and review of the literature. ( 15735865 )
2005
15
Extensive posttreatment ganglioneuromatous differentiation of rhabdomyosarcoma: malignant ectomesenchymoma in an infant. ( 12469232 )
2003
16
Malignant ectomesenchymoma of the nose. Case report and review of the literature. ( 12624508 )
2003
17
Disseminated malignant ectomesenchymoma (MEM): case report and review of the literature. ( 11787870 )
2002
18
Primary malignant ectomesenchymoma of the kidney. ( 12383226 )
2002
19
Malignant ectomesenchymoma of the orbit in a child: Case report and review of the literature. ( 12161212 )
2002
20
Somatostatin receptor scintigraphy in the management of cerebral malignant ectomesenchymoma: a case report. ( 11297080 )
2001
21
Rhabdomyosarcoma metastasizing as a malignant ectomesenchymoma. ( 10503746 )
1999
22
Malignant ectomesenchymoma. Case report and review of the literature. ( 10494059 )
1999
23
Spindle cell sarcoma of the kidney with ganglionic elements (malignant ectomesenchymoma) associated with chromosomal abnormalities and a review of the literature. ( 9544170 )
1998
24
Primary malignant ectomesenchymoma of the orbit. ( 9065587 )
1997
25
Malignant ectomesenchymoma in childhood. ( 9025858 )
1996
26
Primary malignant ectomesenchymoma of the orbit. ( 1627516 )
1992
27
Parapharyngeal malignant ectomesenchymoma: combined malignant fibrous histiocytoma and primitive neuroectodermal tumour with neuroglial differentiation. ( 3035038 )
1987
28
Malignant ectomesenchymoma of soft tissue. Report of two cases and review of the literature. ( 2950992 )
1987
29
Malignant ectomesenchymoma (neoplasm of mixed mesenchymal and neuroepithelial origin) of wrist joint. ( 6491565 )
1984

Variations for Malignant Ectomesenchymoma

Expression for Malignant Ectomesenchymoma

Search GEO for disease gene expression data for Malignant Ectomesenchymoma.

Pathways for Malignant Ectomesenchymoma

Pathways related to Malignant Ectomesenchymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.98 HMGA1 HRAS
2 10.65 HMGA1 HRAS

GO Terms for Malignant Ectomesenchymoma

Cellular components related to Malignant Ectomesenchymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 senescence-associated heterochromatin focus GO:0035985 8.62 HMGA1 HMGA2

Biological processes related to Malignant Ectomesenchymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to virus GO:0009615 9.37 HMGA1 HMGA2
2 base-excision repair GO:0006284 9.32 HMGA1 HMGA2
3 regulation of heart contraction GO:0008016 9.26 DES S100A1
4 positive regulation of cellular senescence GO:2000774 9.16 HMGA1 HMGA2
5 senescence-associated heterochromatin focus assembly GO:0035986 8.96 HMGA1 HMGA2
6 oncogene-induced cell senescence GO:0090402 8.62 HMGA1 HMGA2

Molecular functions related to Malignant Ectomesenchymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-(apurinic or apyrimidinic site) endonuclease activity GO:0003906 8.96 HMGA1 HMGA2
2 AT DNA binding GO:0003680 8.62 HMGA1 HMGA2

Sources for Malignant Ectomesenchymoma

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10 dbSNP
11 DGIdb
17 ExPASy
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28 GO
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32 HPO
33 ICD10
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54 NINDS
55 Novoseek
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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