MCID: MLG012
MIFTS: 20

Malignant Epithelial Mesothelioma

Categories: Cancer diseases

Aliases & Classifications for Malignant Epithelial Mesothelioma

MalaCards integrated aliases for Malignant Epithelial Mesothelioma:

Name: Malignant Epithelial Mesothelioma 12 15
Epithelioid Mesothelioma, Malignant 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4489
NCIt 50 C7985
SNOMED-CT 67 65278006
UMLS 70 C0862312

Summaries for Malignant Epithelial Mesothelioma

MalaCards based summary : Malignant Epithelial Mesothelioma, also known as epithelioid mesothelioma, malignant, is related to benign mesothelioma and asbestosis. An important gene associated with Malignant Epithelial Mesothelioma is PTGER4 (Prostaglandin E Receptor 4), and among its related pathways/superpathways is Cell surface interactions at the vascular wall. Affiliated tissues include endothelial, lymph node and testis.

Related Diseases for Malignant Epithelial Mesothelioma

Diseases related to Malignant Epithelial Mesothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 benign mesothelioma 29.9 THBD CEACAM5 CALB2
2 asbestosis 29.7 THBD CALB2
3 mesothelioma, malignant 29.5 THBD CEACAM5 CALB2
4 malignant pleural mesothelioma 29.3 THBD CALB2
5 adenocarcinoma 10.1
6 rete testis neoplasm 10.1 PTGER4 CALB2
7 rete testis adenocarcinoma 10.1 PTGER4 CALB2
8 thymus clear cell carcinoma 10.0 PTGER4 CALB2
9 peritoneal serous adenocarcinoma 10.0 PTGER4 CALB2
10 pilar sheath acanthoma 10.0 PTGER4 CALB2
11 liver fibroma 10.0 THBD CALB2
12 lung sarcomatoid carcinoma 10.0 THBD CALB2
13 colorectal adenocarcinoma 10.0
14 cardiac tamponade 10.0
15 ovary adenocarcinoma 10.0
16 gastric adenocarcinoma 10.0
17 asbestos intoxication 10.0
18 sarcomatoid mesothelioma 9.9 THBD CALB2
19 vulvar eccrine porocarcinoma 9.9 PTGER4 CEACAM5
20 malignant syringoma 9.9 PTGER4 CEACAM5
21 eccrine sweat gland cancer 9.9 PTGER4 CEACAM5
22 sertoli-leydig cell tumor 9.9 THBD CALB2
23 squamous papillomatosis 9.9 PTGER4 CEACAM5
24 cystic basal cell carcinoma 9.9 PTGER4 CEACAM5
25 dermoid cyst of ovary 9.9 CEACAM5 CALB2
26 pericardial tuberculosis 9.9 CEACAM5 CALB2
27 pleural lipoma 9.9 FUT4 CEACAM5
28 myoblastoma 9.9 CEACAM5 CALB2
29 pancreatic mucinous cystadenoma 9.9 CEACAM5 CALB2
30 cystadenoma 9.8 CEACAM5 CALB2
31 borst-jadassohn intraepidermal carcinoma 9.8 PTGER4 CEACAM5
32 mediastinal cancer 9.8 FUT4 CEACAM5
33 ovarian benign neoplasm 9.8 CEACAM5 CALB2
34 gallbladder lymphoma 9.8 FUT4 CEACAM5
35 ovarian germ cell cancer 9.8 CEACAM5 CALB2
36 seminal vesicle adenocarcinoma 9.8 CEACAM5 CALB2
37 ovarian endometrial cancer 9.8 FUT4 CEACAM5
38 thyroid angiosarcoma 9.8 THBD CEACAM5
39 papillary serous adenocarcinoma 9.8 CEACAM5 CALB2
40 acute cholangitis 9.8 THBD CEACAM5
41 polycystic liver disease 1 with or without kidney cysts 9.8 CEACAM5 CALB2
42 mixed cell type cancer 9.8 CEACAM5 CALB2
43 sex cord-gonadal stromal tumor 9.8 CEACAM5 CALB2
44 ovarian cystadenocarcinoma 9.7 CEACAM5 CALB2
45 adenomatoid tumor 9.7 THBD PTGER4 CALB2
46 reproductive organ benign neoplasm 9.7 CEACAM5 CALB2
47 benign teratoma 9.7 CEACAM5 CALB2
48 malignant biphasic mesothelioma 9.7 THBD FUT4 CALB2
49 nephrogenic adenoma of the urethra 9.7 THBD FUT4 CALB2
50 urethra clear cell adenocarcinoma 9.7 THBD FUT4 CALB2

Graphical network of the top 20 diseases related to Malignant Epithelial Mesothelioma:



Diseases related to Malignant Epithelial Mesothelioma

Symptoms & Phenotypes for Malignant Epithelial Mesothelioma

Drugs & Therapeutics for Malignant Epithelial Mesothelioma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 1, Open-Label, Dose-Escalation, Multiple Dose Study of the Safety, Tolerability, and Immune Response of CRS-207 in Adult Subjects With Selected Advanced Solid Tumors Who Have Failed or Who Are Not Candidates for Standard Treatment Terminated NCT00585845 Phase 1

Search NIH Clinical Center for Malignant Epithelial Mesothelioma

Genetic Tests for Malignant Epithelial Mesothelioma

Anatomical Context for Malignant Epithelial Mesothelioma

MalaCards organs/tissues related to Malignant Epithelial Mesothelioma:

40
Endothelial, Lymph Node, Testis

Publications for Malignant Epithelial Mesothelioma

Articles related to Malignant Epithelial Mesothelioma:

(show all 27)
# Title Authors PMID Year
1
Clinicopathologic study of deciduoid mesothelioma using SMARCB1/INI1 immunohistochemistry and fluorescence in situ hybridization. 61
31445842 2019
2
Malignant Peritoneal Mesothelioma Mimicking Recurrent Diverticulitis. 61
30915265 2019
3
[Value of immunocytochemistry in differential diagnosis of gastric adenocarcinoma, reactive mesothelial cells and malignant epithelial mesothelioma in metastatic effusion fluid]. 61
29534357 2018
4
Malignant Mesothelioma of the Tunica Vaginalis Testis. A Clinicopathologic Analysis of Two Cases with a Review of the Literature. 61
27739317 2016
5
Electron microscopy remains the gold standard for the diagnosis of epithelial malignant mesothelioma: a case study. 61
25268063 2015
6
Diagnostic accuracy of Ber-EP4 for metastatic adenocarcinoma in serous effusions: a meta-analysis. 61
25229691 2014
7
Vascular endothelial growth factor receptor 2 as a marker for malignant vascular tumors and mesothelioma: an immunohistochemical study of 262 vascular endothelial and 1640 nonvascular tumors. 61
22314185 2012
8
Paratesticular mesothelioma in young age. Case report. 61
22920171 2012
9
Cytological differential diagnosis among adenocarcinoma, epithelial mesothelioma, and reactive mesothelial cells in serous effusions by immunocytochemistry. 61
20836004 2011
10
Establishment of a human malignant fibrous mesothelioma cell line and the biological characteristics compared with malignant epithelial mesothelioma cell line. 61
18667024 2008
11
Malignant mesothelioma with intracytoplasmic crystalline inclusions. 61
17455100 2007
12
Prognostic value of pleural fluid pH in malignant epithelial mesothelioma after talc poudrage. 61
16679752 2006
13
Value of antimesothelioma HBME-1 in the diagnosis of inflammatory and malignant pleural effusions. 61
17392981 2006
14
Immunophenotypings of malignant epithelial mesothelioma and their roles in the differential diagnosis. 61
15315156 2004
15
Long microvilli of mesothelioma are conspicuous in pleural effusions processed by Ultrafast Papanicolaou stain. 61
12589641 2003
16
[Small-cell mesothelioma of the pleura: description of a case]. 61
12417972 2002
17
An autopsy case of diffuse malignant mesothelioma of the pericardium. 61
9051694 1997
18
Malignant epithelial mesothelioma of the peritoneum: observations on a problem case. 61
8837340 1996
19
Transsternal transpericardial operations in the treatment of bronchopleural fistulas after pneumonectomy. 61
8664010 1996
20
Varieties of serous surface papillary carcinoma of the peritoneum in northern Germany: a thirty-year autopsy study. 61
8598333 1995
21
Immunohistochemical properties of malignant mesothelioma cells in histologic and cytologic specimens. 61
7534025 1995
22
Malignant epithelial mesothelioma presenting as cardiac tamponade. 61
8299643 1993
23
[Immunohistochemistry of mesotheliomas. Technique and current diagnostic contribution of immunohistochemical markers. General review]. 61
8135582 1993
24
Lymph node metastasis as the initial manifestation of malignant mesothelioma. Report of six cases. 61
2389813 1990
25
Malignant mesothelioma in infancy. 61
2650654 1989
26
Flow cytometric analysis of ploidy in immunohistochemically confirmed examples of malignant epithelial mesothelioma. 61
3414598 1988
27
Malignant epithelial mesothelioma of the anterior mediastinum. 61
6585691 1984

Variations for Malignant Epithelial Mesothelioma

Expression for Malignant Epithelial Mesothelioma

Search GEO for disease gene expression data for Malignant Epithelial Mesothelioma.

Pathways for Malignant Epithelial Mesothelioma

Pathways related to Malignant Epithelial Mesothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.87 THBD CEACAM5

GO Terms for Malignant Epithelial Mesothelioma

Cellular components related to Malignant Epithelial Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.8 THBD FUT4 CEACAM5

Biological processes related to Malignant Epithelial Mesothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 8.62 THBD PTGER4

Sources for Malignant Epithelial Mesothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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