MCID: MLG145
MIFTS: 26

Malignant Epithelioid Hemangioendothelioma

Categories: Cancer diseases, Cardiovascular diseases, Fetal diseases, Rare diseases

Aliases & Classifications for Malignant Epithelioid Hemangioendothelioma

MalaCards integrated aliases for Malignant Epithelioid Hemangioendothelioma:

Name: Malignant Epithelioid Hemangioendothelioma 12 15
Epithelioid Hemangioendothelioma, Malignant 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0080190
NCIt 50 C3800
UMLS 70 C0334538

Summaries for Malignant Epithelioid Hemangioendothelioma

Disease Ontology : 12 A malignant hemangioma characterized by the presence of epithelioid endothelial cells. The neoplastic cells are arranged in cords and nests, which are embedded in a myxoid to hyalinized stroma.

MalaCards based summary : Malignant Epithelioid Hemangioendothelioma, also known as epithelioid hemangioendothelioma, malignant, is related to hemangioendothelioma and epithelioid hemangioendothelioma. An important gene associated with Malignant Epithelioid Hemangioendothelioma is CAMTA1 (Calmodulin Binding Transcription Activator 1), and among its related pathways/superpathways are Tyrosine Kinases / Adaptors and TGF-beta Signaling Pathway (WikiPathways). Affiliated tissues include endothelial, thyroid and colon.

Related Diseases for Malignant Epithelioid Hemangioendothelioma

Diseases in the Epithelioid Hemangioendothelioma family:

Malignant Epithelioid Hemangioendothelioma

Diseases related to Malignant Epithelioid Hemangioendothelioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 hemangioendothelioma 30.7 WWTR1 FOSB CAMTA1
2 epithelioid hemangioendothelioma 30.1 YAP1 WWTR1 TFE3 CAMTA1
3 mesenchymal cell neoplasm 29.9 TFE3 SERPINA3
4 angiosarcoma 10.4
5 rare vascular tumor 10.3
6 rare tumor 10.3
7 lipomatosis, multiple 10.0
8 multinodular goiter 10.0
9 hepatic veno-occlusive disease 10.0
10 pleomorphic lipoma 10.0
11 goiter 10.0
12 endemic goiter 10.0
13 gaucher's disease 10.0
14 adenocarcinoma 10.0
15 pituitary adenoma 10.0
16 bronchiolo-alveolar adenocarcinoma 10.0
17 infiltrating lipoma 10.0
18 aneurysm 10.0
19 thyroid tumor 10.0
20 myeloproliferative syndrome, transient 9.9 YAP1 WWTR1
21 embryonal rhabdomyosarcoma 9.8 YAP1 WWTR1
22 xanthogranulomatous pyelonephritis 9.8 TFE3 SERPINA3
23 wilson-turner x-linked mental retardation syndrome 9.8 YAP1 WWTR1
24 perivascular tumor 9.8 TFE3 SERPINA3
25 ovarian serous cystadenocarcinoma 9.8 YAP1 SERPINA3
26 malignant hemangioma 9.8 WWTR1 SERPINA3 CAMTA1
27 skeletal muscle cancer 9.8 TFE3 SERPINA3
28 muscle cancer 9.7 TFE3 SERPINA3
29 proliferative fasciitis 9.7 SERPINA3 FOSB CAMTA1
30 sveinsson chorioretinal atrophy 9.7 YAP1 WWTR1 SERPINA3
31 cystadenocarcinoma 9.7 YAP1 SERPINA3
32 vascular cancer 9.3 WWTR1 TFE3 SERPINA3 CAMTA1
33 histiocytoid hemangioma 9.0 YAP1 WWTR1 TFE3 FOSB CAMTA1

Graphical network of the top 20 diseases related to Malignant Epithelioid Hemangioendothelioma:



Diseases related to Malignant Epithelioid Hemangioendothelioma

Symptoms & Phenotypes for Malignant Epithelioid Hemangioendothelioma

Drugs & Therapeutics for Malignant Epithelioid Hemangioendothelioma

Search Clinical Trials , NIH Clinical Center for Malignant Epithelioid Hemangioendothelioma

Genetic Tests for Malignant Epithelioid Hemangioendothelioma

Anatomical Context for Malignant Epithelioid Hemangioendothelioma

MalaCards organs/tissues related to Malignant Epithelioid Hemangioendothelioma:

40
Endothelial, Thyroid, Colon, Adrenal Gland, Skeletal Muscle, Pituitary, Liver

Publications for Malignant Epithelioid Hemangioendothelioma

Articles related to Malignant Epithelioid Hemangioendothelioma:

(show all 45)
# Title Authors PMID Year
1
Hepatic vascular malignancies in children are associated with increased rates of surgical resection and improved overall survival compared with adults. 61
33661569 2021
2
Endothelial cell malignancies in infants, children and adolescents: Treatment results of three Cooperative Weichteilsarkom Studiengruppe (CWS) trials and one registry. 61
31814291 2020
3
Orbital Cellular Epithelioid Hemangioma. 61
31768366 2019
4
The Molecular Diagnostics of Vascular Neoplasms. 61
30709447 2019
5
Epithelioid hemangioendothelioma of the mandibular gingiva: A rare case of metastasis 4 years after radical excision and literature review. 61
27194877 2016
6
Molecular imaging of glutamate-carboxypeptidase II (prostate-specific membrane antigen) in malignant epithelioid hemangioendothelioma. 61
26260651 2015
7
Thalassemia major between liver and heart: Where we are now. 61
25976473 2015
8
Malignant epithelioid hemangioendothelioma of the adrenal gland treated by laparoscopic excision. 61
25733308 2015
9
Hepatic epithelioid hemangioendothelioma in a patient with hemochromatosis. 61
25190690 2014
10
Malignant epithelioid hemangioendothelioma of the lip: a case report and comprehensive literature review. 61
24268966 2014
11
Primitive pulmonary "malignant epithelioid hemangioendothelioma" versus epithelioid angiosarcoma. A case report and review of the literature. 61
25073215 2014
12
Ileal malignant hemangioendothelioma as a hypervascular lesion on computed tomography scan. 61
24394857 2014
13
Malignant vascular tumors--an update. 61
24384851 2014
14
Malignant epithelioid hemangioendothelioma: a case report. 61
23599886 2013
15
Malignant epithelioid hemangioendothelioma progressing after chemotherapy and Interferon treatment: a case presentation and a brief review of the literature. 61
23575093 2013
16
Serial bone scintigraphy in a case of malignant epithelioid hemangioendothelioma. 61
22391717 2012
17
Malignant epithelioid hemangioendothelioma of the liver successfully treated with Sorafenib. 61
22826791 2012
18
An older patient with bilateral non-traumatic haemothoraces. 61
22605796 2012
19
Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. 61
22330038 2012
20
A case of pulmonary malignant epithelioid hemangioendothelioma misdiagnosed as adenocarcinoma by fine needle aspiration cytology. 61
21994192 2011
21
Malignant epithelioid hemangioendothelioma of the liver successfully treated with pegylated liposomal doxorubicin. 61
21788568 2011
22
Malignant epithelioid hemangioendothelioma of the lower extremity: staging with F-18 FDG PET/CT. 61
21637069 2011
23
Malignant epithelioid hemangioendothelioma of the bladder: the first case report in a child. 61
19573676 2009
24
F-18 FDG PET/CT monitoring of radiation therapeutic effect in hepatic epithelioid hemangioendothelioma. 61
19352294 2009
25
Malignant epithelioid hemangioendothelioma with spindle phenotype: report of an unusual case diagnosed by fine needle aspiration cytology. 61
19068679 2008
26
Hepatic malignant epithelioid hemangioendothelioma: a case report and review of the literature. 61
18274433 2008
27
[Malignant epithelioid hemangioendothelioma of the liver. Results of surgical treatment strategies]. 61
16096736 2005
28
An authentic malignant epithelioid hemangioendothelioma of the thyroid: a case report and review of the literature. 61
16405412 2005
29
[Bilateral pulmonary nodules in an HIV-infected patient]. 61
15257228 2004
30
Malignant epithelioid hemangioendothelioma presenting as an aneurysm of the superficial palmar arch: a case report. 61
12132094 2002
31
Vascular tumors simulating occlusive disease. 61
11284093 2001
32
[Malignant epithelioid hemangioendothelioma of the liver - a very rare tumor in children]. 61
10591953 1999
33
Epithelioid hemangioendothelioma with marked liver deformity and secondary Budd-Chiari syndrome: pathological and radiological correlation. 61
10469398 1999
34
Complex translocation [7;22] identified in an epithelioid hemangioendothelioma. 61
8976367 1996
35
Establishment and characterization of a malignant epithelioid hemangioendothelioma from mouse thyroid tumor. 61
7670562 1995
36
Malignant epithelioid hemangioendothelioma of the tibia associated with a bone infarct in a patient who had Gaucher disease. A case report. 61
7744904 1995
37
Malignant epithelioid hemangioendothelioma arising in an intramuscular lipoma. 61
8431858 1993
38
[Malignant epithelioid hemangioendothelioma of the liver. Description of a case]. 61
2143303 1990
39
Scintigraphic features of malignant epithelioid hemangioendothelioma. 61
2766632 1989
40
Epithelioid hemangioendothelioma of the liver following contact with vinyl chloride. Recurrence after orthotopic liver transplantation. 61
2646369 1989
41
Malignant epithelioid hemangioendothelioma at the site of a hip prosthesis. 61
3381668 1988
42
Malignant epithelioid hemangioendothelioma of the colon. Report of a case. 61
3622180 1987
43
Malignant epithelioid hemangioendothelioma of the liver in young women. Relationship to oral contraceptive use. 61
3904492 1985
44
Lung metastasis of malignant epithelioid hemangioendothelioma mimicking a primary intravascular bronchioalveolar tumor. A histologic, ultrastructural, and immunohistochemical study. 61
2579721 1985
45
Malignant epithelioid hemangioendothelioma of the liver, spreading through the hepatic veins. 61
6437065 1984

Variations for Malignant Epithelioid Hemangioendothelioma

Expression for Malignant Epithelioid Hemangioendothelioma

Search GEO for disease gene expression data for Malignant Epithelioid Hemangioendothelioma.

Pathways for Malignant Epithelioid Hemangioendothelioma

Pathways related to Malignant Epithelioid Hemangioendothelioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.49 YAP1 WWTR1
2 11.38 YAP1 FOSB
3 11.12 YAP1 WWTR1
4 10.42 YAP1 WWTR1
5 9.95 YAP1 WWTR1

GO Terms for Malignant Epithelioid Hemangioendothelioma

Cellular components related to Malignant Epithelioid Hemangioendothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.1 YAP1 WWTR1 TFE3 SERPINA3 FOSB CAMTA1

Biological processes related to Malignant Epithelioid Hemangioendothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.73 YAP1 WWTR1 TFE3 FOSB
2 positive regulation of osteoblast differentiation GO:0045669 9.48 YAP1 WWTR1
3 negative regulation of fat cell differentiation GO:0045599 9.46 YAP1 WWTR1
4 response to progesterone GO:0032570 9.4 YAP1 FOSB
5 positive regulation of protein localization to nucleus GO:1900182 9.37 YAP1 WWTR1
6 regulation of canonical Wnt signaling pathway GO:0060828 9.32 YAP1 WWTR1
7 hippo signaling GO:0035329 9.26 YAP1 WWTR1
8 tissue homeostasis GO:0001894 9.16 YAP1 WWTR1
9 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 8.96 YAP1 WWTR1
10 heart process GO:0003015 8.62 YAP1 WWTR1

Molecular functions related to Malignant Epithelioid Hemangioendothelioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 8.62 FOSB CAMTA1

Sources for Malignant Epithelioid Hemangioendothelioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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