MCID: MLG039
MIFTS: 27

Malignant Essential Hypertension

Categories: Cardiovascular diseases, Genetic diseases, Blood diseases, Rare diseases

Aliases & Classifications for Malignant Essential Hypertension

MalaCards integrated aliases for Malignant Essential Hypertension:

Name: Malignant Essential Hypertension 12 15 73
Accelerated Essential Hypertension 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10823
ICD9CM 35 401.0
NCIt 50 C34802
SNOMED-CT 68 1218009 78975002
UMLS 73 C0024588

Summaries for Malignant Essential Hypertension

MalaCards based summary : Malignant Essential Hypertension, also known as accelerated essential hypertension, is related to hypertension, essential and multicystic dysplastic kidney. An important gene associated with Malignant Essential Hypertension is KLKB1 (Kallikrein B1), and among its related pathways/superpathways is Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics.

Related Diseases for Malignant Essential Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension

Diseases related to Malignant Essential Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 hypertension, essential 27.1 ACE AGTR2 ENSG00000264813 KLK4 KLKB1 KNG1
2 multicystic dysplastic kidney 10.7 AGTR2 REN
3 hemoglobin lepore-beta-thalassemia syndrome 10.7 HBB HBD
4 hemoglobin d disease 10.7 HBB HBD
5 hemoglobin e disease 10.6 HBB HBD
6 hemoglobin c disease 10.6 HBB HBD
7 osgood-schlatter's disease 10.6 HBB HBD
8 fetal hemoglobin quantitative trait locus 1 10.6 HBB HBD
9 kluver-bucy syndrome 10.6 HBB HBD
10 periodontosis 10.5 HLA-A KLK4
11 haemophilus meningitis 10.5 HLA-A TNFRSF25
12 c1 inhibitor deficiency 10.5 KLKB1 KNG1
13 pleuropneumonia 10.5 HBB HBD
14 juvenile dermatitis herpetiformis 10.5 HLA-A TNFRSF25
15 adrenal cortical hypofunction 10.4 REN TNFRSF25
16 pleural disease 10.3 KLKB1 KNG1
17 renal tuberculosis 10.3 ENSG00000264813 REN
18 tricuspid valve stenosis 10.3 ARSE ENSG00000264813
19 diffuse scleroderma 10.3 KNG1 TNFRSF25
20 allergic urticaria 10.2 ENSG00000264813 KNG1
21 familial vesicoureteral reflux 10.1 ACE AGTR2
22 hyporeninemic hypoaldosteronism 10.1 ACE REN
23 renal artery obstruction 10.1 ACE REN
24 hypoaldosteronism 10.1 ACE REN
25 hypertensive encephalopathy 10.1 ACE REN
26 posterior urethral valves 10.1 ACE AGTR2
27 hypertensive retinopathy 10.1 ACE REN
28 renal artery disease 10.0 ACE REN
29 hypertension, diastolic 10.0 ACE REN
30 atrial septal defect 4 10.0 ACE REN
31 anuria 10.0 ACE REN
32 malignant hypertension 10.0 ACE REN
33 fibromuscular dysplasia 10.0 ACE REN
34 hepatorenal syndrome 9.9 ACE REN
35 loeffler syndrome 9.9 ACE ENSG00000264813
36 renal tubular dysgenesis 9.9 ACE REN
37 fiedler's myocarditis 9.9 ACE ENSG00000264813
38 pure autonomic failure 9.8 ACE REN
39 renovascular hypertension 9.8 ACE REN
40 granulomatous hepatitis 9.8 ACE KLK4
41 subdural empyema 9.8 ACE ENSG00000264813
42 pseudohyperkalemia, familial, 2, due to red cell leak 9.7 ACE AGTR2 REN
43 optic nerve sheath meningioma 9.7 ACE SAMHD1
44 ureteral disease 9.7 ACE REN
45 arteriosclerosis 9.7
46 aneurysm 9.7
47 amyotrophic lateral sclerosis 10 with or without frontotemporal dementia 9.7 ENSG00000264813 SAMHD1
48 mitral valve insufficiency 9.6 ACE SAMHD1
49 hereditary angioedema 9.6 ACE KLKB1 KNG1
50 angioedema 9.6 ACE KLKB1 KNG1

Comorbidity relations with Malignant Essential Hypertension via Phenotypic Disease Network (PDN): (show all 38)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Anxiety
Aortic Valve Disease 1 Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypertensive Encephalopathy Hypertensive Retinopathy
Hypothyroidism Intermediate Coronary Syndrome
Intracranial Thrombosis Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Malignant Renovascular Hypertension Mitral Valve Disease
Peripheral Vascular Disease Renal Artery Atheroma
Respiratory Failure Schizophreniform Disorder
Sinoatrial Node Disease Swallowing Disorders
Transient Cerebral Ischemia Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Malignant Essential Hypertension:



Diseases related to Malignant Essential Hypertension

Symptoms & Phenotypes for Malignant Essential Hypertension

Drugs & Therapeutics for Malignant Essential Hypertension

Search Clinical Trials , NIH Clinical Center for Malignant Essential Hypertension

Genetic Tests for Malignant Essential Hypertension

Anatomical Context for Malignant Essential Hypertension

Publications for Malignant Essential Hypertension

Articles related to Malignant Essential Hypertension:

(show all 13)
# Title Authors Year
1
Human leukocyte antigens and malignant essential hypertension. ( 9657633 )
1998
2
Does non-malignant essential hypertension cause renal damage? A clinician's view. ( 9004097 )
1996
3
Urinary kallikrein excretion is low in malignant essential hypertension. ( 1325521 )
1992
4
Renal haemodynamics and comparative effects of captopril in patients with benign- or malignant-essential hypertension, or with chronic renal failure. ( 3301082 )
1987
5
Predisposing factors for the development of malignant essential hypertension. ( 3662703 )
1987
6
Prospective measurement of glomerular filtration rate and effective renal plasma flow during treatment of malignant essential hypertension. ( 6494086 )
1984
7
Renal function as an indicator of prognosis in malignant essential hypertension. ( 7089493 )
1982
8
Immunological changes in patients with previous malignant essential hypertension. ( 6110039 )
1981
9
Vascular lesions of malignant essential hypertension. ( 5567956 )
1971
10
Vascular lesions of malignant essential hypertension. ( 5567174 )
1971
11
Vascular lesions of malignant essential hypertension. ( 5504381 )
1970
12
Successful twin pregnancy after treatment of malignant essential hypertension. ( 13572832 )
1958
13
Clinicopathologic conference; generalized arteriosclerosis; malignant essential hypertension with dissecting aneurysm of the artery and coronary occlusion. ( 15426209 )
1950

Variations for Malignant Essential Hypertension

Expression for Malignant Essential Hypertension

Search GEO for disease gene expression data for Malignant Essential Hypertension.

Pathways for Malignant Essential Hypertension

Pathways related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.83 ACE AGTR2 KNG1 REN

GO Terms for Malignant Essential Hypertension

Cellular components related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.33 HBB HBD KNG1
2 extracellular region GO:0005576 9.23 ACE AGTR2 HBB KLK4 KLKB1 KNG1
3 hemoglobin complex GO:0005833 8.96 HBB HBD

Biological processes related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.78 AGTR2 KLKB1 KNG1 TNFRSF25
2 proteolysis GO:0006508 9.72 ACE ENSG00000264813 KLK4 KLKB1 REN
3 positive regulation of nitric oxide biosynthetic process GO:0045429 9.55 AGTR2 HBB
4 blood vessel remodeling GO:0001974 9.54 ACE AGTR2
5 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.52 ACE HLA-A
6 vasodilation GO:0042311 9.51 AGTR2 KNG1
7 regulation of blood vessel size GO:0050880 9.49 HBB KNG1
8 blood coagulation, intrinsic pathway GO:0007597 9.46 KLKB1 KNG1
9 blood coagulation GO:0007596 9.46 HBB HBD KLKB1 KNG1
10 oxygen transport GO:0015671 9.43 HBB HBD
11 amyloid-beta metabolic process GO:0050435 9.4 ACE REN
12 regulation of blood vessel diameter GO:0097746 9.37 ACE AGTR2
13 angiotensin maturation GO:0002003 9.26 ACE REN
14 renin-angiotensin regulation of aldosterone production GO:0002018 8.96 AGTR2 REN
15 regulation of blood pressure GO:0008217 8.92 ACE AGTR2 HBB REN

Molecular functions related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.7 ACE ARSE ENSG00000264813 KLK4 KLKB1 REN
2 iron ion binding GO:0005506 9.54 HBB HBD KLKB1
3 heme binding GO:0020037 9.5 HBB HBD KLKB1
4 peptidase activity GO:0008233 9.35 ACE ENSG00000264813 KLK4 KLKB1 REN
5 oxygen carrier activity GO:0005344 9.26 HBB HBD
6 peptidyl-dipeptidase activity GO:0008241 8.62 ACE ENSG00000264813
7 metal ion binding GO:0046872 10.01 ACE ARSE ENSG00000264813 HBB HBD KLK4

Sources for Malignant Essential Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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