MCID: MLG039
MIFTS: 30

Malignant Essential Hypertension

Categories: Blood diseases, Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Malignant Essential Hypertension

MalaCards integrated aliases for Malignant Essential Hypertension:

Name: Malignant Essential Hypertension 12 15 73
Accelerated Essential Hypertension 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10823
ICD9CM 35 401.0
NCIt 50 C34802
SNOMED-CT 68 1218009 78975002
UMLS 73 C0024588

Summaries for Malignant Essential Hypertension

MalaCards based summary : Malignant Essential Hypertension, also known as accelerated essential hypertension, is related to hypertension, essential and multicystic dysplastic kidney. An important gene associated with Malignant Essential Hypertension is KLKB1 (Kallikrein B1), and among its related pathways/superpathways are Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics and MSP-RON Signaling. Affiliated tissues include kidney and heart.

Related Diseases for Malignant Essential Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension

Diseases related to Malignant Essential Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 hypertension, essential 29.4 REN KNG1 KLKB1 KLK4 ENSG00000264813 AGTR2
2 multicystic dysplastic kidney 10.2 REN AGTR2
3 hemoglobin lepore-beta-thalassemia syndrome 10.2 HBD HBB
4 hemoglobin d disease 10.2 HBD HBB
5 hemoglobin c disease 10.2 HBD HBB
6 hemoglobin e disease 10.2 HBD HBB
7 osgood-schlatter's disease 10.2 HBD HBB
8 fetal hemoglobin quantitative trait locus 1 10.2 HBD HBB
9 kluver-bucy syndrome 10.2 HBD HBB
10 periodontosis 10.1 KLK4 HLA-A
11 blind loop syndrome 10.1 HBD HBB
12 pleuropneumonia 10.1 HBD HBB
13 blood protein disease 10.1 HBD HBB
14 haemophilus meningitis 10.1 TNFRSF25 HLA-A
15 juvenile dermatitis herpetiformis 10.1 TNFRSF25 HLA-A
16 adrenal cortical hypofunction 10.1 TNFRSF25 REN
17 iron overload in africa 10.1 HLA-A HBB
18 tricuspid valve stenosis 10.1 ENSG00000264813 ARSE
19 renal tuberculosis 10.1 REN ENSG00000264813
20 alpha thalassemia-intellectual disability syndrome type 1 10.0 HBB HBD
21 familial vesicoureteral reflux 10.0 AGTR2 ACE
22 allergic urticaria 10.0 KNG1 ENSG00000264813
23 hyporeninemic hypoaldosteronism 10.0 REN ACE
24 hypoaldosteronism 10.0 REN ACE
25 renal artery obstruction 10.0 REN ACE
26 diffuse scleroderma 10.0 TNFRSF25 KNG1
27 hemoglobin h disease 10.0 HBB HBD
28 c1 inhibitor deficiency 10.0 KNG1 KLKB1 KLK4
29 posterior urethral valves 10.0 AGTR2 ACE
30 hypertensive encephalopathy 10.0 REN ACE
31 hypertension, diastolic 10.0 REN ACE
32 renal artery disease 10.0 REN ACE
33 hypertensive retinopathy 10.0 REN ACE
34 anuria 10.0 REN ACE
35 malignant hypertension 10.0 REN ACE
36 loeffler syndrome 10.0 ENSG00000264813 ACE
37 hepatorenal syndrome 10.0 REN ACE
38 uveoparotid fever 10.0 ENSG00000264813 ACE
39 fibromuscular dysplasia 10.0 REN ACE
40 autoimmune atherosclerosis 10.0 ENSG00000264813 ACE
41 fiedler's myocarditis 9.9 ENSG00000264813 ACE
42 renal tubular dysgenesis 9.9 REN ACE
43 pure autonomic failure 9.9 ACE REN
44 renovascular hypertension 9.9 ACE REN
45 heart valve disease 9.9 REN ARSE ACE
46 subdural empyema 9.9 ENSG00000264813 ACE
47 pseudohyperkalemia, familial, 2, due to red cell leak 9.9 REN AGTR2 ACE
48 obstructive nephropathy 9.9 REN AGTR2 ACE
49 sickle cell disease 9.9 HBB HBD
50 hypersensitivity reaction type iv disease 9.8 ACE ENSG00000264813

Comorbidity relations with Malignant Essential Hypertension via Phenotypic Disease Network (PDN): (show all 38)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Anxiety
Aortic Valve Disease 1 Basilar Artery Insufficiency
Benign Essential Hypertension Bronchitis
Cerebral Atherosclerosis Cerebrovascular Disease
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Esophagitis Familial Atrial Fibrillation
First-Degree Atrioventricular Block Generalized Atherosclerosis
Heart Disease Hypertension, Essential
Hypertensive Encephalopathy Hypertensive Retinopathy
Hypothyroidism Intermediate Coronary Syndrome
Intracranial Thrombosis Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Malignant Renovascular Hypertension Mitral Valve Disease
Peripheral Vascular Disease Renal Artery Atheroma
Respiratory Failure Schizophreniform Disorder
Sinoatrial Node Disease Swallowing Disorders
Transient Cerebral Ischemia Vertebral Artery Insufficiency

Graphical network of the top 20 diseases related to Malignant Essential Hypertension:



Diseases related to Malignant Essential Hypertension

Symptoms & Phenotypes for Malignant Essential Hypertension

Drugs & Therapeutics for Malignant Essential Hypertension

Search Clinical Trials , NIH Clinical Center for Malignant Essential Hypertension

Genetic Tests for Malignant Essential Hypertension

Anatomical Context for Malignant Essential Hypertension

MalaCards organs/tissues related to Malignant Essential Hypertension:

41
Kidney, Heart

Publications for Malignant Essential Hypertension

Articles related to Malignant Essential Hypertension:

(show all 15)
# Title Authors Year
1
Bilateral papillophlebitis in a patient with accelerated essential hypertension. ( 18025657 )
2007
2
Human leukocyte antigens and malignant essential hypertension. ( 9657633 )
1998
3
Does non-malignant essential hypertension cause renal damage? A clinician's view. ( 9004097 )
1996
4
Elevated sympathetic nerve activity in patients with accelerated essential hypertension. ( 8325991 )
1993
5
Urinary kallikrein excretion is low in malignant essential hypertension. ( 1325521 )
1992
6
Renal haemodynamics and comparative effects of captopril in patients with benign- or malignant-essential hypertension, or with chronic renal failure. ( 3301082 )
1987
7
Predisposing factors for the development of malignant essential hypertension. ( 3662703 )
1987
8
Prospective measurement of glomerular filtration rate and effective renal plasma flow during treatment of malignant essential hypertension. ( 6494086 )
1984
9
Renal function as an indicator of prognosis in malignant essential hypertension. ( 7089493 )
1982
10
Immunological changes in patients with previous malignant essential hypertension. ( 6110039 )
1981
11
Vascular lesions of malignant essential hypertension. ( 5567956 )
1971
12
Vascular lesions of malignant essential hypertension. ( 5567174 )
1971
13
Vascular lesions of malignant essential hypertension. ( 5504381 )
1970
14
Successful twin pregnancy after treatment of malignant essential hypertension. ( 13572832 )
1958
15
Clinicopathologic conference; generalized arteriosclerosis; malignant essential hypertension with dissecting aneurysm of the artery and coronary occlusion. ( 15426209 )
1950

Variations for Malignant Essential Hypertension

Expression for Malignant Essential Hypertension

Search GEO for disease gene expression data for Malignant Essential Hypertension.

Pathways for Malignant Essential Hypertension

Pathways related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.83 ACE AGTR2 KNG1 REN
2 10.64 KLK4 KLKB1

GO Terms for Malignant Essential Hypertension

Cellular components related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 ACE ARSE HBB HLA-A KLKB1 KNG1
2 extracellular space GO:0005615 9.8 ACE ENSG00000264813 HBB KLKB1 KNG1 REN
3 blood microparticle GO:0072562 9.43 HBB HBD KNG1
4 extracellular region GO:0005576 9.23 ACE AGTR2 HBB KLK4 KLKB1 KNG1
5 hemoglobin complex GO:0005833 9.16 HBB HBD
6 haptoglobin-hemoglobin complex GO:0031838 8.96 HBB HBD

Biological processes related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.77 ACE ENSG00000264813 KLK4 KLKB1 REN
2 positive regulation of nitric oxide biosynthetic process GO:0045429 9.57 AGTR2 HBB
3 blood vessel remodeling GO:0001974 9.56 ACE AGTR2
4 antigen processing and presentation of peptide antigen via MHC class I GO:0002474 9.55 ACE HLA-A
5 hydrogen peroxide catabolic process GO:0042744 9.54 HBB HBD
6 positive regulation of blood pressure GO:0045777 9.52 ACE ENSG00000264813
7 vasodilation GO:0042311 9.51 AGTR2 KNG1
8 regulation of blood vessel size GO:0050880 9.49 HBB KNG1
9 blood coagulation, intrinsic pathway GO:0007597 9.48 KLKB1 KNG1
10 oxygen transport GO:0015671 9.46 HBB HBD
11 amyloid-beta metabolic process GO:0050435 9.43 ACE REN
12 regulation of blood vessel diameter GO:0097746 9.4 ACE AGTR2
13 angiotensin maturation GO:0002003 9.32 ACE REN
14 positive regulation of systemic arterial blood pressure GO:0003084 9.26 ACE ENSG00000264813
15 blood coagulation GO:0007596 9.26 HBB HBD KLKB1 KNG1
16 renin-angiotensin regulation of aldosterone production GO:0002018 9.16 AGTR2 REN
17 regulation of blood pressure GO:0008217 8.92 ACE AGTR2 HBB REN

Molecular functions related to Malignant Essential Hypertension according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 hydrolase activity GO:0016787 9.97 ACE ARSE ENSG00000264813 KLK4 KLKB1 REN
2 heme binding GO:0020037 9.63 HBB HBD KLKB1
3 peptidase activity GO:0008233 9.55 ACE ENSG00000264813 KLK4 KLKB1 REN
4 oxygen binding GO:0019825 9.52 HBB HBD
5 peroxidase activity GO:0004601 9.51 HBB HBD
6 carboxypeptidase activity GO:0004180 9.48 ACE ENSG00000264813
7 dipeptidyl-peptidase activity GO:0008239 9.43 ACE ENSG00000264813
8 oxygen carrier activity GO:0005344 9.4 HBB HBD
9 organic acid binding GO:0043177 9.37 HBB HBD
10 haptoglobin binding GO:0031720 9.32 HBB HBD
11 exopeptidase activity GO:0008238 9.26 ACE ENSG00000264813
12 peptidyl-dipeptidase activity GO:0008241 8.96 ACE ENSG00000264813
13 hemoglobin alpha binding GO:0031721 8.62 HBB HBD

Sources for Malignant Essential Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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