MCID: MLG168
MIFTS: 30

Malignant Exocrine Pancreas Neoplasm

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Malignant Exocrine Pancreas Neoplasm

MalaCards integrated aliases for Malignant Exocrine Pancreas Neoplasm:

Name: Malignant Exocrine Pancreas Neoplasm 12
Malignant Neoplasm of the Exocrine Pancreas 12
Malignant Tumour of Exocrine Pancreas 12
Malignant Tumor of Exocrine Pancreas 12
Tumor of Exocrine Pancreas 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1795
NCIt 50 C7430
SNOMED-CT 67 255088001
UMLS 71 C0346648

Summaries for Malignant Exocrine Pancreas Neoplasm

Disease Ontology : 12 A pancreatic cancer that arises from the epithelial cells of the exocrine pancreatic tissue.

MalaCards based summary : Malignant Exocrine Pancreas Neoplasm, also known as malignant neoplasm of the exocrine pancreas, is related to gastric tubular adenocarcinoma and hepatic flexure cancer. An important gene associated with Malignant Exocrine Pancreas Neoplasm is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Metabolism of proteins and Toll-like Receptor Signaling Pathway. Affiliated tissues include pancreas, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Malignant Exocrine Pancreas Neoplasm

Diseases in the Benign Exocrine Pancreas Neoplasm family:

Malignant Exocrine Pancreas Neoplasm

Diseases related to Malignant Exocrine Pancreas Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)
# Related Disease Score Top Affiliating Genes
1 gastric tubular adenocarcinoma 10.4 MUC6 MUC5AC
2 hepatic flexure cancer 10.4 KRAS HRAS
3 cobblestone retinal degeneration 10.4 KRAS HRAS
4 colloid carcinoma of the pancreas 10.3 MUC5AC MUC1
5 ampulla of vater neoplasm 10.3 KRAS HRAS
6 periampullary adenoma 10.3 KRAS HRAS
7 acneiform dermatitis 10.3 KRAS HRAS
8 gallbladder benign neoplasm 10.3 KRAS HRAS
9 adenosquamous lung carcinoma 10.3 KRAS HRAS
10 mucinous lung adenocarcinoma 10.3 KRAS HRAS
11 wolffian duct adenocarcinoma 10.3 KRAS HRAS
12 myh-associated polyposis 10.3 KRAS HRAS
13 noonan syndrome-like disorder with loose anagen hair 1 10.3 KRAS HRAS
14 noonan syndrome-like disorder with loose anagen hair 10.3 KRAS HRAS
15 mucinous tubular and spindle renal cell carcinoma 10.3 MUC6 MUC1
16 filamentary keratitis 10.3 MUC5AC MUC1
17 anal gland adenocarcinoma 10.3 MUC5AC CDX2
18 syringocystadenoma papilliferum 10.3 MUC1 KRAS
19 anus adenocarcinoma 10.3 MUC5AC CDX2
20 serrated polyposis syndrome 10.3 RNF43 KRAS
21 limbal stem cell deficiency 10.3 MUC5AC MUC1
22 pancreatic acinar cell adenocarcinoma 10.3 KRAS HRAS
23 paronychia 10.3 KRAS HRAS
24 colorectal cancer, hereditary nonpolyposis, type 8 10.3 MUC5AC MUC1
25 ethmoid sinus cancer 10.3 HRAS CDX2
26 endosalpingiosis 10.3 MUC1 KRAS
27 lung carcinoma in situ 10.3 KRAS HRAS
28 core binding factor acute myeloid leukemia 10.3 KRAS HRAS
29 pulmonary adenocarcinoma in situ 10.3 KRAS HRAS
30 oculoectodermal syndrome 10.3 KRAS HRAS
31 chronic ethmoiditis 10.2 MUC6 MUC5AC MUC1
32 solid adenocarcinoma with mucin production 10.2 MUC6 MUC5AC MUC1
33 basosquamous carcinoma 10.2 TP53 MUC6
34 colorectal cancer 1 10.2 MUC6 MUC5AC MUC1
35 periosteal osteogenic sarcoma 10.2 TP53 GNAS
36 spiradenoma 10.2 TP53 MUC1
37 intrahepatic biliary papillomatosis 10.2 MUC5AC MUC1 KRAS
38 schimmelpenning-feuerstein-mims syndrome 10.2 KRAS HRAS GNAS
39 peripheral osteosarcoma 10.2 TP53 GNAS
40 nevus, epidermal 10.2 KRAS HRAS GNAS
41 conjunctival degeneration 10.2 TP53 MUC5AC
42 liver angiosarcoma 10.2 TP53 KRAS
43 cystadenofibroma 10.2 TP53 MUC1
44 mammary analogue secretory carcinoma 10.2 TP53 MUC1
45 arteriovenous malformation 10.2 SMAD4 KRAS HRAS
46 malignant peritoneal mesothelioma 10.1 MUC1 CDKN2A
47 ovarian serous cystadenofibroma 10.1 TP53 MUC1
48 endometrioid ovary carcinoma 10.1 TP53 KRAS
49 ethmoid sinus adenocarcinoma 10.1 KRAS HRAS CDX2
50 bile reflux 10.1 MUC5AC CDX2

Graphical network of the top 20 diseases related to Malignant Exocrine Pancreas Neoplasm:



Diseases related to Malignant Exocrine Pancreas Neoplasm

Symptoms & Phenotypes for Malignant Exocrine Pancreas Neoplasm

MGI Mouse Phenotypes related to Malignant Exocrine Pancreas Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.91 A4GNT CDKN2A CDX2 HRAS KRAS MUC5AC
2 endocrine/exocrine gland MP:0005379 9.76 CDKN2A CDX2 GNAS HRAS KRAS RNF43
3 neoplasm MP:0002006 9.61 A4GNT CDKN2A CDX2 GNAS HRAS KRAS
4 normal MP:0002873 9.17 CDX2 GNAS HRAS KRAS RBM10 SMAD4

Drugs & Therapeutics for Malignant Exocrine Pancreas Neoplasm

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Study of Distal Pancreatectomy With Partial Splenectomy for Pancreatic Tumors Arising in the Body and Tail of the Pancreas Withdrawn NCT01412684

Search NIH Clinical Center for Malignant Exocrine Pancreas Neoplasm

Genetic Tests for Malignant Exocrine Pancreas Neoplasm

Anatomical Context for Malignant Exocrine Pancreas Neoplasm

MalaCards organs/tissues related to Malignant Exocrine Pancreas Neoplasm:

40
Pancreas

Publications for Malignant Exocrine Pancreas Neoplasm

Articles related to Malignant Exocrine Pancreas Neoplasm:

# Title Authors PMID Year
1
Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement: Two case reports and literature review. 61
28930825 2017

Variations for Malignant Exocrine Pancreas Neoplasm

Expression for Malignant Exocrine Pancreas Neoplasm

Search GEO for disease gene expression data for Malignant Exocrine Pancreas Neoplasm.

Pathways for Malignant Exocrine Pancreas Neoplasm

Pathways related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.59 TP53 SMAD4 MUC6 MUC5AC MUC1 CEACAM5
2
Show member pathways
12.94 TP53 SMAD4 KRAS HRAS GNAS
3
Show member pathways
12.8 TP53 KRAS HRAS GNAS CDKN2A
4
Show member pathways
12.74 TP53 SMAD4 KRAS HRAS CDKN2A
5 12.57 TP53 SMAD4 KRAS HRAS GNAS CDKN2A
6
Show member pathways
12.52 TP53 KRAS HRAS GNAS CDKN2A
7 12.4 TP53 KRAS HRAS CDKN2A
8
Show member pathways
12.4 TP53 SMAD4 KRAS HRAS CDX2 CDKN2A
9
Show member pathways
12.32 TP53 SMAD4 MUC1 KRAS HRAS
10 12.17 TP53 KRAS HRAS CDKN2A
11
Show member pathways
12.13 MUC6 MUC5AC MUC1 KRAS HRAS
12
Show member pathways
12.11 MUC6 MUC5AC MUC1 A4GNT
13 12.05 TP53 SMAD4 KRAS GNAS
14 11.99 TP53 KRAS HRAS CDKN2A
15
Show member pathways
11.97 SMAD4 KRAS HRAS
16 11.97 SMAD4 KRAS HRAS
17 11.91 TP53 KRAS HRAS
18 11.89 TP53 KRAS HRAS
19 11.89 TP53 SMAD4 KRAS HRAS CDKN2A
20 11.87 KRAS HRAS GNAS
21
Show member pathways
11.85 KRAS HRAS GNAS
22
Show member pathways
11.84 MUC6 MUC5AC MUC1
23 11.79 SMAD4 KRAS HRAS
24 11.78 TP53 KRAS HRAS CDKN2A
25 11.73 KRAS HRAS GNAS
26 11.73 TP53 SMAD4 HRAS CDKN2A
27 11.61 TP53 KRAS HRAS
28 11.58 TP53 KRAS HRAS
29 11.52 KRAS HRAS GNAS
30 11.13 SMAD4 KRAS HRAS
31 11.12 TP53 KRAS HRAS CDKN2A
32 11.08 TP53 SMAD4 KRAS HRAS CDKN2A
33 10.96 KRAS HRAS
34 10.74 KRAS HRAS

GO Terms for Malignant Exocrine Pancreas Neoplasm

Cellular components related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.8 MUC6 MUC5AC MUC1

Biological processes related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.69 TP53 HRAS CDKN2A
2 negative regulation of cell growth GO:0030308 9.65 TP53 SMAD4 CDKN2A
3 negative regulation of cell proliferation GO:0008285 9.65 TP53 SMAD4 RBM10 HRAS CDKN2A
4 positive regulation of cellular senescence GO:2000774 9.52 KRAS CDKN2A
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.49 KRAS HRAS
6 replicative senescence GO:0090399 9.46 TP53 CDKN2A
7 Ras protein signal transduction GO:0007265 9.46 TP53 KRAS HRAS CDKN2A
8 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.43 TP53 MUC1
9 response to isolation stress GO:0035900 9.4 KRAS HRAS
10 positive regulation of smooth muscle cell apoptotic process GO:0034393 9.37 RBM10 CDKN2A
11 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0036003 9.32 TP53 MUC1
12 O-glycan processing GO:0016266 9.26 MUC6 MUC5AC MUC1 A4GNT
13 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.02 MUC6 MUC5AC MUC1 KRAS HRAS

Molecular functions related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MDM2/MDM4 family protein binding GO:0097371 8.96 TP53 CDKN2A
2 p53 binding GO:0002039 8.8 TP53 MUC1 CDKN2A

Sources for Malignant Exocrine Pancreas Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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