Malignant Exocrine Pancreas Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MLG168 MIFTS: 30	Malignant Exocrine Pancreas Neoplasm Categories: Cancer diseases, Endocrine diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Malignant Exocrine Pancreas Neoplasm

MalaCards integrated aliases for Malignant Exocrine Pancreas Neoplasm:

Name: Malignant Exocrine Pancreas Neoplasm ¹²

Malignant Neoplasm of the Exocrine Pancreas ¹²

Malignant Tumour of Exocrine Pancreas ¹²

Malignant Tumor of Exocrine Pancreas ¹²

Tumor of Exocrine Pancreas ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:1795

NCIt ⁵⁰ C7430

SNOMED-CT ⁶⁷ 255088001

UMLS ⁷¹ C0346648

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Summaries for Malignant Exocrine Pancreas Neoplasm

Disease Ontology : ¹² A pancreatic cancer that arises from the epithelial cells of the exocrine pancreatic tissue.

MalaCards based summary : Malignant Exocrine Pancreas Neoplasm, also known as malignant neoplasm of the exocrine pancreas, is related to gastric tubular adenocarcinoma and hepatic flexure cancer. An important gene associated with Malignant Exocrine Pancreas Neoplasm is MUC6 (Mucin 6, Oligomeric Mucus/Gel-Forming), and among its related pathways/superpathways are Metabolism of proteins and Toll-like Receptor Signaling Pathway. Affiliated tissues include pancreas, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

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Related Diseases for Malignant Exocrine Pancreas Neoplasm

Diseases in the Benign Exocrine Pancreas Neoplasm family:

Malignant Exocrine Pancreas Neoplasm

Diseases related to Malignant Exocrine Pancreas Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)

#	Related Disease	Score	Top Affiliating Genes
1	gastric tubular adenocarcinoma	10.4	MUC6 MUC5AC
2	hepatic flexure cancer	10.4	KRAS HRAS
3	cobblestone retinal degeneration	10.4	KRAS HRAS
4	colloid carcinoma of the pancreas	10.3	MUC5AC MUC1
5	ampulla of vater neoplasm	10.3	KRAS HRAS
6	periampullary adenoma	10.3	KRAS HRAS
7	acneiform dermatitis	10.3	KRAS HRAS
8	gallbladder benign neoplasm	10.3	KRAS HRAS
9	adenosquamous lung carcinoma	10.3	KRAS HRAS
10	mucinous lung adenocarcinoma	10.3	KRAS HRAS
11	wolffian duct adenocarcinoma	10.3	KRAS HRAS
12	myh-associated polyposis	10.3	KRAS HRAS
13	noonan syndrome-like disorder with loose anagen hair 1	10.3	KRAS HRAS
14	noonan syndrome-like disorder with loose anagen hair	10.3	KRAS HRAS
15	mucinous tubular and spindle renal cell carcinoma	10.3	MUC6 MUC1
16	filamentary keratitis	10.3	MUC5AC MUC1
17	anal gland adenocarcinoma	10.3	MUC5AC CDX2
18	syringocystadenoma papilliferum	10.3	MUC1 KRAS
19	anus adenocarcinoma	10.3	MUC5AC CDX2
20	serrated polyposis syndrome	10.3	RNF43 KRAS
21	limbal stem cell deficiency	10.3	MUC5AC MUC1
22	pancreatic acinar cell adenocarcinoma	10.3	KRAS HRAS
23	paronychia	10.3	KRAS HRAS
24	colorectal cancer, hereditary nonpolyposis, type 8	10.3	MUC5AC MUC1
25	ethmoid sinus cancer	10.3	HRAS CDX2
26	endosalpingiosis	10.3	MUC1 KRAS
27	lung carcinoma in situ	10.3	KRAS HRAS
28	core binding factor acute myeloid leukemia	10.3	KRAS HRAS
29	pulmonary adenocarcinoma in situ	10.3	KRAS HRAS
30	oculoectodermal syndrome	10.3	KRAS HRAS
31	chronic ethmoiditis	10.2	MUC6 MUC5AC MUC1
32	solid adenocarcinoma with mucin production	10.2	MUC6 MUC5AC MUC1
33	basosquamous carcinoma	10.2	TP53 MUC6
34	colorectal cancer 1	10.2	MUC6 MUC5AC MUC1
35	periosteal osteogenic sarcoma	10.2	TP53 GNAS
36	spiradenoma	10.2	TP53 MUC1
37	intrahepatic biliary papillomatosis	10.2	MUC5AC MUC1 KRAS
38	schimmelpenning-feuerstein-mims syndrome	10.2	KRAS HRAS GNAS
39	peripheral osteosarcoma	10.2	TP53 GNAS
40	nevus, epidermal	10.2	KRAS HRAS GNAS
41	conjunctival degeneration	10.2	TP53 MUC5AC
42	liver angiosarcoma	10.2	TP53 KRAS
43	cystadenofibroma	10.2	TP53 MUC1
44	mammary analogue secretory carcinoma	10.2	TP53 MUC1
45	arteriovenous malformation	10.2	SMAD4 KRAS HRAS
46	malignant peritoneal mesothelioma	10.1	MUC1 CDKN2A
47	ovarian serous cystadenofibroma	10.1	TP53 MUC1
48	endometrioid ovary carcinoma	10.1	TP53 KRAS
49	ethmoid sinus adenocarcinoma	10.1	KRAS HRAS CDX2
50	bile reflux	10.1	MUC5AC CDX2

Graphical network of the top 20 diseases related to Malignant Exocrine Pancreas Neoplasm:

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Symptoms & Phenotypes for Malignant Exocrine Pancreas Neoplasm

MGI Mouse Phenotypes related to Malignant Exocrine Pancreas Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.91	A4GNT CDKN2A CDX2 HRAS KRAS MUC5AC
2	endocrine/exocrine gland	MP:0005379	9.76	CDKN2A CDX2 GNAS HRAS KRAS RNF43
3	neoplasm	MP:0002006	9.61	A4GNT CDKN2A CDX2 GNAS HRAS KRAS
4	normal	MP:0002873	9.17	CDX2 GNAS HRAS KRAS RBM10 SMAD4

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Drugs & Therapeutics for Malignant Exocrine Pancreas Neoplasm

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Pilot Study of Distal Pancreatectomy With Partial Splenectomy for Pancreatic Tumors Arising in the Body and Tail of the Pancreas	Withdrawn	NCT01412684

Search NIH Clinical Center for Malignant Exocrine Pancreas Neoplasm

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Genetic Tests for Malignant Exocrine Pancreas Neoplasm

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Anatomical Context for Malignant Exocrine Pancreas Neoplasm

MalaCards organs/tissues related to Malignant Exocrine Pancreas Neoplasm:

⁴⁰

Pancreas

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Publications for Malignant Exocrine Pancreas Neoplasm

Articles related to Malignant Exocrine Pancreas Neoplasm:

#	Title	Authors	PMID	Year
1	Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement: Two case reports and literature review. ⁶¹	Luo Y...Li F	28930825	2017

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Genes for Malignant Exocrine Pancreas Neoplasm

Genes related to Malignant Exocrine Pancreas Neoplasm (0 elite genes):

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	6.82	DISEASES inferred ¹⁵
2	GNAS	GNAS Complex Locus	Protein Coding	6.59	DISEASES inferred ¹⁵
3	MUC5AC	Mucin 5AC, Oligomeric Mucus/Gel-Forming	Protein Coding	6.24	DISEASES inferred ¹⁵
4	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	5.86	DISEASES inferred ¹⁵
5	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	5.78	DISEASES inferred ¹⁵
6	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	5.68	DISEASES inferred ¹⁵
7	SMAD4	SMAD Family Member 4	Protein Coding	5.66	DISEASES inferred ¹⁵
8	RNF43	Ring Finger Protein 43	Protein Coding	5.53	DISEASES inferred ¹⁵
9	CDX2	Caudal Type Homeobox 2	Protein Coding	5.5	DISEASES inferred ¹⁵
10	RBM10	RNA Binding Motif Protein 10	Protein Coding	5.48	DISEASES inferred ¹⁵
11	A4GNT	Alpha-1,4-N-Acetylglucosaminyltransferase	Protein Coding	5.37	DISEASES inferred ¹⁵
12	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	5.02	DISEASES inferred ¹⁵
13	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	5.02	DISEASES inferred ¹⁵
14	TP53	Tumor Protein P53	Protein Coding	4.98	DISEASES inferred ¹⁵

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Variations for Malignant Exocrine Pancreas Neoplasm

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Expression for Malignant Exocrine Pancreas Neoplasm

Search GEO for disease gene expression data for Malignant Exocrine Pancreas Neoplasm.

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Pathways for Malignant Exocrine Pancreas Neoplasm

Pathways related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

(show all 34)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁵ Show member pathways Post-translational protein modification ⁶⁵	13.59	TP53 SMAD4 MUC6 MUC5AC MUC1 CEACAM5
2	Toll-like Receptor Signaling Pathway ³⁶ ¹ Show member pathways Chagas disease ³⁶ Hepatitis B ³⁶ Hepatitis C ³⁶ Regulation of toll-like receptor signaling pathway ¹	12.94	TP53 SMAD4 KRAS HRAS GNAS
3	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.8	TP53 KRAS HRAS GNAS CDKN2A
4	Endometrial cancer ³⁶ Show member pathways Acute myeloid leukemia ³⁶ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁵ Chronic myeloid leukemia ³⁶ Colorectal cancer ³⁶ Pancreatic cancer ³⁶ Prostate cancer ³⁶ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁶	12.74	TP53 SMAD4 KRAS HRAS CDKN2A
5	Pathways in cancer ³⁶	12.57	TP53 SMAD4 KRAS HRAS GNAS CDKN2A
6	Glioma ³⁶ Show member pathways Endocrine resistance ³⁶ Melanoma ³⁶ Non-small cell lung cancer ³⁶ Signaling Pathways in Glioblastoma ¹	12.52	TP53 KRAS HRAS GNAS CDKN2A
7	MicroRNAs in cancer ³⁶	12.4	TP53 KRAS HRAS CDKN2A
8	Gastric cancer ³⁶ Show member pathways Breast cancer ³⁶ Hepatocellular carcinoma ³⁶	12.4	TP53 SMAD4 KRAS HRAS CDX2 CDKN2A
9	VEGF Signaling ⁶⁶ Show member pathways EGFR Signaling Pathway ⁶⁶ TGF-beta Signaling Pathway ⁶⁶ VEGF Signaling Pathway ⁶⁰	12.32	TP53 SMAD4 MUC1 KRAS HRAS
10	Viral carcinogenesis ³⁶	12.17	TP53 KRAS HRAS CDKN2A
11	CLEC7A (Dectin-1) signaling ⁶⁵ Show member pathways Alternative NF-kappaB pathway ¹ CLEC7A/inflammasome pathway ⁶⁵ C-type lectin receptors (CLRs) ⁶⁵	12.13	MUC6 MUC5AC MUC1 KRAS HRAS
12	O-linked glycosylation ⁶⁵ Show member pathways O-linked glycosylation of mucins ⁶⁵	12.11	MUC6 MUC5AC MUC1 A4GNT
13	Colorectal Cancer Metastasis ⁶³	12.05	TP53 SMAD4 KRAS GNAS
14	Cellular senescence (KEGG) ³⁶	11.99	TP53 KRAS HRAS CDKN2A
15	FoxO signaling pathway ³⁶ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	11.97	SMAD4 KRAS HRAS
16	Apelin signaling pathway ³⁶	11.97	SMAD4 KRAS HRAS
17	Thyroid hormone signaling pathway ³⁶	11.91	TP53 KRAS HRAS
18	Sphingolipid signaling pathway ³⁶	11.89	TP53 KRAS HRAS
19	Human T-cell leukemia virus 1 infection ³⁶	11.89	TP53 SMAD4 KRAS HRAS CDKN2A
20	Serotonergic synapse ³⁶	11.87	KRAS HRAS GNAS
21	Long-term potentiation ³⁶ Show member pathways Common Pathways Underlying Drug Addiction ¹	11.85	KRAS HRAS GNAS
22	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) ⁶⁵ Show member pathways Dectin-2 family ⁶⁵ Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) ⁶⁵ Defective GALNT12 causes colorectal cancer 1 (CRCS1) ⁶⁵ Termination of O-glycan biosynthesis ⁶⁵	11.84	MUC6 MUC5AC MUC1
23	AGE-RAGE signaling pathway in diabetic complications ³⁶	11.79	SMAD4 KRAS HRAS
24	Glioblastoma Multiforme ⁶³	11.78	TP53 KRAS HRAS CDKN2A
25	Gap junction ³⁶	11.73	KRAS HRAS GNAS
26	Senescence and Autophagy in Cancer ¹	11.73	TP53 SMAD4 HRAS CDKN2A
27	Central carbon metabolism in cancer ³⁶	11.61	TP53 KRAS HRAS
28	Mitophagy - animal ³⁶	11.58	TP53 KRAS HRAS
29	Long-term depression ³⁶	11.52	KRAS HRAS GNAS
30	Extracellular vesicle-mediated signaling in recipient cells ¹	11.13	SMAD4 KRAS HRAS
31	Bladder cancer ³⁶ ¹	11.12	TP53 KRAS HRAS CDKN2A
32	DNA Damage Response (only ATM dependent) ¹	11.08	TP53 SMAD4 KRAS HRAS CDKN2A
33	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling ¹	10.96	KRAS HRAS
34	p38MAPK events ⁶⁵	10.74	KRAS HRAS

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GO Terms for Malignant Exocrine Pancreas Neoplasm

Cellular components related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:0005796	8.8	MUC6 MUC5AC MUC1

Biological processes related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell cycle arrest	GO:0007050	9.69	TP53 HRAS CDKN2A
2	negative regulation of cell growth	GO:0030308	9.65	TP53 SMAD4 CDKN2A
3	negative regulation of cell proliferation	GO:0008285	9.65	TP53 SMAD4 RBM10 HRAS CDKN2A
4	positive regulation of cellular senescence	GO:2000774	9.52	KRAS CDKN2A
5	regulation of long-term neuronal synaptic plasticity	GO:0048169	9.49	KRAS HRAS
6	replicative senescence	GO:0090399	9.46	TP53 CDKN2A
7	Ras protein signal transduction	GO:0007265	9.46	TP53 KRAS HRAS CDKN2A
8	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:0006978	9.43	TP53 MUC1
9	response to isolation stress	GO:0035900	9.4	KRAS HRAS
10	positive regulation of smooth muscle cell apoptotic process	GO:0034393	9.37	RBM10 CDKN2A
11	positive regulation of transcription from RNA polymerase II promoter in response to stress	GO:0036003	9.32	TP53 MUC1
12	O-glycan processing	GO:0016266	9.26	MUC6 MUC5AC MUC1 A4GNT
13	stimulatory C-type lectin receptor signaling pathway	GO:0002223	9.02	MUC6 MUC5AC MUC1 KRAS HRAS

Molecular functions related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MDM2/MDM4 family protein binding	GO:0097371	8.96	TP53 CDKN2A
2	p53 binding	GO:0002039	8.8	TP53 MUC1 CDKN2A

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