Malignant Exocrine Pancreas Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Malignant Exocrine Pancreas Neoplasm

MalaCards integrated aliases for Malignant Exocrine Pancreas Neoplasm:

Name: Malignant Exocrine Pancreas Neoplasm ¹¹ ¹⁴

Malignant Neoplasm of the Exocrine Pancreas ¹¹

Malignant Tumour of Exocrine Pancreas ¹¹

Malignant Tumor of Exocrine Pancreas ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:1795

NCIt ⁴⁹ C7430

SNOMED-CT ⁶⁸ 255088001

UMLS ⁷¹ C0346648

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Summaries for Malignant Exocrine Pancreas Neoplasm

Disease Ontology: ¹¹ A pancreatic cancer that arises from the epithelial cells of the exocrine pancreatic tissue.

MalaCards based summary: Malignant Exocrine Pancreas Neoplasm, also known as malignant neoplasm of the exocrine pancreas, is related to glioma and bacterial infectious disease. An important gene associated with Malignant Exocrine Pancreas Neoplasm is MIR21 (MicroRNA 21), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. Affiliated tissues include pancreas.

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Related Diseases for Malignant Exocrine Pancreas Neoplasm

Diseases in the Benign Exocrine Pancreas Neoplasm family:

Malignant Exocrine Pancreas Neoplasm

Diseases related to Malignant Exocrine Pancreas Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 316)

#	Related Disease	Score	Top Affiliating Genes
1	glioma	10.6	MIR221 MIR21 MIR17 MIR10B
2	bacterial infectious disease	10.6	MIR21 ICOSLG H2AC18 CCR6
3	cystadenocarcinoma	10.6	MIR30A MIR21 MIR199A1
4	serous cystadenocarcinoma	10.5	MIR30A MIR21 MIR199A1 H2AC18
5	papillary adenocarcinoma	10.5	MIR30A MIR221 MIR21 MIR10B
6	ovarian clear cell carcinoma	10.5	MIR221 MIR21 MIR199A1 H2AC18
7	ovarian cystadenocarcinoma	10.5	MIR30A MIR196A1 MIR17 ICOSLG H2AC18
8	peripheral artery disease	10.5	MIR21 MIR199A1 MIR17 MIR126
9	ovary adenocarcinoma	10.5	MIR30A MIR196A1 MIR17 ICOSLG H2AC18
10	cystic echinococcosis	10.5	MIR30A MIR21 H2AC18
11	ovarian serous cystadenocarcinoma	10.5	MIR30A MIR196A1 MIR17 ICOSLG H2AC18
12	oropharynx cancer	10.5	MIR21 MIR199A1 MIR196A1 H2AC18
13	parasitic helminthiasis infectious disease	10.5	MIR21 ICOSLG H2AC18 CCR6
14	bone deterioration disease	10.5	MIR21 MIR17 MIR143 MIR126
15	intermediate coronary syndrome	10.5	MIR21 MIR17 MIR145 MIR142 MIR126
16	pre-malignant neoplasm	10.5	MIR30A MIR17 MIR142 H2AC18 CCR6
17	blood protein disease	10.5	MIR126 ICOSLG H2AC18 CCR6
18	aortic valve disease 2	10.5	MIR21 MIR199A1 MIR17 MIR126 H2AC18
19	polymyositis	10.5	MIR501 MIR30A MIR221 MIR21
20	dermatomyositis	10.5	MIR501 MIR30A MIR221 MIR21
21	autoimmune disease of exocrine system	10.5	MIR142 ICOSLG H2AC18 CCR6
22	primary cutaneous t-cell non-hodgkin lymphoma	10.5	MIR21 MIR17 H2AC18 CCR6
23	listeriosis	10.5	MIR125A ICOSLG H2AC18 CCR6
24	lymph node disease	10.5	MIR145 ICOSLG H2AC18 CCR6
25	coronavirus infectious disease	10.5	MIR21 ICOSLG H2AC18 CCR6
26	vascular disease	10.5	MIR21 MIR199A1 MIR145 MIR143 MIR126 MIR125A
27	lichen disease	10.5	MIR31 MIR142 ICOSLG CCR6
28	respiratory allergy	10.5	MIR21 MIR142 ICOSLG CCR6
29	cervix small cell carcinoma	10.5	MIR199A1 MIR145 MIR143 MIR10B
30	rectal benign neoplasm	10.5	MIR31 MIR17 MIR145 MIR143
31	mature t-cell and nk-cell lymphoma	10.5	MIR21 MIR199A1 MIR17 ICOSLG H2AC18 CCR6
32	adult t-cell leukemia/lymphoma	10.5	MIR142 ICOSLG H2AC18 CCR6
33	esophagus adenocarcinoma	10.5	MIR21 MIR199A1 MIR196A1 MIR145 MIR143
34	aortic aneurysm, familial abdominal, 1	10.5	MIR21 MIR199A1 MIR126 H2AC18 CCR6
35	microvascular complications of diabetes 5	10.5	MIR30A MIR21 MIR199A1 MIR17 MIR126 H2AC18
36	large cell carcinoma	10.5	MIR31 MIR30A MIR17 MIR145 MIR126
37	intrahepatic cholangiocarcinoma	10.5	MIR199A1 MIR17 MIR142 MIR126 H2AC18
38	suppression of tumorigenicity 12	10.5	MIR30A MIR221 MIR145 ICOSLG H2AC18
39	chromosomal deletion syndrome	10.5	MIR21 MIR17 MIR142 ICOSLG H2AC18 CCR6
40	limb ischemia	10.5	MIR21 MIR17 MIR126
41	chronic fatigue syndrome	10.5	MIR142 MIR126 H2AC18 CCR6
42	cardiovascular organ benign neoplasm	10.5	MIR199A1 MIR17 MIR143 H2AC18 CCR6
43	peripheral t-cell lymphoma	10.5	MIR21 MIR199A1 MIR17 ICOSLG H2AC18 CCR6
44	skin melanoma	10.5	MIR21 MIR199A1 ICOSLG H2AC18 CCR6
45	autoimmune pancreatitis	10.5	MIR21 ICOSLG CCR6
46	autoimmune myocarditis	10.5	ICOSLG H2AC18 CCR6
47	alcohol use disorder	10.5	MIR199A1 MIR196A1 H2AC18 CCR6
48	non-alcoholic steatohepatitis	10.5	MIR21 MIR199A1 MIR142 CCR6
49	thyroid gland follicular carcinoma	10.5	MIR221 MIR199A1 MIR17 MIR125A
50	heart valve disease	10.5	MIR21 MIR199A1 MIR17 MIR142 MIR126 H2AC18

Graphical network of the top 20 diseases related to Malignant Exocrine Pancreas Neoplasm:

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Symptoms & Phenotypes for Malignant Exocrine Pancreas Neoplasm

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Drugs & Therapeutics for Malignant Exocrine Pancreas Neoplasm

Search Clinical Trials, NIH Clinical Center for Malignant Exocrine Pancreas Neoplasm

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Genetic Tests for Malignant Exocrine Pancreas Neoplasm

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Anatomical Context for Malignant Exocrine Pancreas Neoplasm

Organs/tissues related to Malignant Exocrine Pancreas Neoplasm:

MalaCards : Pancreas

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Publications for Malignant Exocrine Pancreas Neoplasm

Articles related to Malignant Exocrine Pancreas Neoplasm:

#	Title	Authors	PMID	Year
1	Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement: Two case reports and literature review. ⁶²	Luo Y...Li F	28930825	2017
2	Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases. ⁶²	Guo X...Feng Z	27123293	2016

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Genes for Malignant Exocrine Pancreas Neoplasm

Genes related to Malignant Exocrine Pancreas Neoplasm (0 elite genes):

(show top 50) (show all 84)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR21	MicroRNA 21	RNA Gene	11.36	DISEASES inferred ¹⁴ ¹⁴
2	MIR196A1	MicroRNA 196a-1	RNA Gene	10.93	DISEASES inferred ¹⁴ ¹⁴
3	MIR17	MicroRNA 17	RNA Gene	10.47	DISEASES inferred ¹⁴ ¹⁴
4	MIR221	MicroRNA 221	RNA Gene	10.05	DISEASES inferred ¹⁴ ¹⁴
5	H2AC18	H2A Clustered Histone 18	Protein Coding	9.9	DISEASES inferred ¹⁴ ¹⁴
6	MIR216A	MicroRNA 216a	RNA Gene	9.89	DISEASES inferred ¹⁴ ¹⁴
7	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.88	DISEASES inferred ¹⁴ ¹⁴
8	MIR30A	MicroRNA 30a	RNA Gene	9.82	DISEASES inferred ¹⁴ ¹⁴
9	MIR126	MicroRNA 126	RNA Gene	9.75	DISEASES inferred ¹⁴ ¹⁴
10	MIR10B	MicroRNA 10b	RNA Gene	9.66	DISEASES inferred ¹⁴ ¹⁴
11	MIR615	MicroRNA 615	RNA Gene	9.65	DISEASES inferred ¹⁴ ¹⁴
12	MIR31	MicroRNA 31	RNA Gene	9.62	DISEASES inferred ¹⁴ ¹⁴
13	MIR501	MicroRNA 501	RNA Gene	9.6	DISEASES inferred ¹⁴ ¹⁴
14	MIR145	MicroRNA 145	RNA Gene	9.52	DISEASES inferred ¹⁴ ¹⁴
15	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	9.5	DISEASES inferred ¹⁴ ¹⁴
16	MIR142	MicroRNA 142	RNA Gene	9.45	DISEASES inferred ¹⁴ ¹⁴
17	MIR199A1	MicroRNA 199a-1	RNA Gene	9.43	DISEASES inferred ¹⁴ ¹⁴
18	MIR125A	MicroRNA 125a	RNA Gene	9.42	DISEASES inferred ¹⁴ ¹⁴
19	MIR23A	MicroRNA 23a	RNA Gene	9.42	DISEASES inferred ¹⁴ ¹⁴
20	MIR143	MicroRNA 143	RNA Gene	9.38	DISEASES inferred ¹⁴ ¹⁴
21	MIR34A	MicroRNA 34a	RNA Gene	9.34	DISEASES inferred ¹⁴ ¹⁴
22	MIR216B	MicroRNA 216b	RNA Gene	9.28	DISEASES inferred ¹⁴ ¹⁴
23	MIR200C	MicroRNA 200c	RNA Gene	9.2	DISEASES inferred ¹⁴ ¹⁴
24	MIR486-1	MicroRNA 486-1	RNA Gene	9.2	DISEASES inferred ¹⁴ ¹⁴
25	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	9.13	DISEASES inferred ¹⁴
26	U2AF1	U2 Small Nuclear RNA Auxiliary Factor 1	Protein Coding	9.09	DISEASES inferred ¹⁴ ¹⁴
27	MIR20A	MicroRNA 20a	RNA Gene	9.08	DISEASES inferred ¹⁴ ¹⁴
28	MIR214	MicroRNA 214	RNA Gene	9.07	DISEASES inferred ¹⁴ ¹⁴
29	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	9.04	DISEASES inferred ¹⁴
30	MIR361	MicroRNA 361	RNA Gene	8.93	DISEASES inferred ¹⁴ ¹⁴
31	MIR200B	MicroRNA 200b	RNA Gene	8.92	DISEASES inferred ¹⁴ ¹⁴
32	MIR483	MicroRNA 483	RNA Gene	8.85	DISEASES inferred ¹⁴ ¹⁴
33	CDR1-AS	CDR1 Antisense RNA	RNA Gene	8.85	DISEASES inferred ¹⁴ ¹⁴
34	MIR185	MicroRNA 185	RNA Gene	8.8	DISEASES inferred ¹⁴ ¹⁴
35	SERPINA3	Serpin Family A Member 3	Protein Coding	8.79	DISEASES inferred ¹⁴ ¹⁴
36	MIR338	MicroRNA 338	RNA Gene	8.78	DISEASES inferred ¹⁴ ¹⁴
37	MIR330	MicroRNA 330	RNA Gene	8.77	DISEASES inferred ¹⁴ ¹⁴
38	MIR18A	MicroRNA 18a	RNA Gene	8.76	DISEASES inferred ¹⁴ ¹⁴
39	MIR139	MicroRNA 139	RNA Gene	8.73	DISEASES inferred ¹⁴ ¹⁴
40	MIR181A1	MicroRNA 181a-1	RNA Gene	8.67	DISEASES inferred ¹⁴ ¹⁴
41	MIR150	MicroRNA 150	RNA Gene	8.62	DISEASES inferred ¹⁴ ¹⁴
42	MIR26A1	MicroRNA 26a-1	RNA Gene	8.58	DISEASES inferred ¹⁴ ¹⁴
43	MIR130B	MicroRNA 130b	RNA Gene	8.55	DISEASES inferred ¹⁴ ¹⁴
44	MIR212	MicroRNA 212	RNA Gene	8.54	DISEASES inferred ¹⁴ ¹⁴
45	MIR101-1	MicroRNA 101-1	RNA Gene	8.54	DISEASES inferred ¹⁴ ¹⁴
46	KDM4C	Lysine Demethylase 4C	Protein Coding	8.48	DISEASES inferred ¹⁴ ¹⁴
47	MIR183	MicroRNA 183	RNA Gene	8.45	DISEASES inferred ¹⁴ ¹⁴
48	TP53	Tumor Protein P53	Protein Coding	8.43	DISEASES inferred ¹⁴
49	MIR193A	MicroRNA 193a	RNA Gene	8.43	DISEASES inferred ¹⁴ ¹⁴
50	MIR9-1	MicroRNA 9-1	RNA Gene	8.43	DISEASES inferred ¹⁴ ¹⁴

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Variations for Malignant Exocrine Pancreas Neoplasm

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Expression for Malignant Exocrine Pancreas Neoplasm

Search GEO for disease gene expression data for Malignant Exocrine Pancreas Neoplasm.

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Pathways for Malignant Exocrine Pancreas Neoplasm

Pathways related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	miRNAs involvement in the immune response in sepsis ⁷⁴	11.25	MIR21 MIR199A1 MIR145 MIR126
2	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.25	MIR221 MIR199A1 MIR17 MIR145 MIR143
3	miRNAs involved in DNA damage response ⁷⁴	10.93	MIR23A MIR221 MIR21 MIR17 MIR145 MIR143

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GO Terms for Malignant Exocrine Pancreas Neoplasm

Cellular components related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.97	MIR501 MIR31 MIR30A MIR23A MIR221 MIR21
2	RISC complex	GO:0016442	9.84	MIR10B MIR125A MIR126 MIR142 MIR143 MIR145
3	extracellular vesicle	GO:1903561	9.5	MIR30A MIR23A MIR221 MIR21 MIR17 MIR126

Biological processes related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

(show all 29)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of cell migration	GO:0030336	9.94	MIR31 MIR21 MIR145 MIR126
2	negative regulation of angiogenesis	GO:0016525	9.9	MIR21 MIR145 MIR143 MIR125A
3	positive regulation of angiogenesis	GO:0045766	9.88	MIR126 MIR143 MIR199A1 MIR21 MIR30A MIR31
4	positive regulation of protein kinase B signaling	GO:0051897	9.85	MIR221 MIR21 MIR199A1 MIR143 MIR126
5	positive regulation of vascular associated smooth muscle cell proliferation	GO:1904707	9.8	MIR221 MIR21 MIR17
6	negative regulation of inflammatory response	GO:0050728	9.8	MIR31 MIR221 MIR199A1 MIR145 MIR142 MIR126
7	miRNA-mediated gene silencing	GO:0035195	9.8	MIR10B MIR125A MIR126 MIR142 MIR143 MIR145
8	negative regulation of cell migration involved in sprouting angiogenesis	GO:0090051	9.77	MIR221 MIR199A1 MIR196A1
9	negative regulation of cardiac muscle cell apoptotic process	GO:0010667	9.76	MIR21 MIR199A1 MIR145
10	positive regulation of sprouting angiogenesis	GO:1903672	9.73	MIR31 MIR126 MIR125A
11	positive regulation of cell migration involved in sprouting angiogenesis	GO:0090050	9.73	MIR31 MIR23A MIR126 MIR10B
12	positive regulation of vascular associated smooth muscle cell migration	GO:1904754	9.7	MIR221 MIR21 MIR143
13	negative regulation of vascular endothelial growth factor production	GO:1904046	9.69	MIR199A1 MIR17 MIR125A
14	cell growth involved in cardiac muscle cell development	GO:0061049	9.64	MIR23A MIR199A1
15	angiotensin-activated signaling pathway	GO:0038166	9.63	MIR145 MIR143
16	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.62	MIR199A1 MIR17
17	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.62	MIR21 MIR17
18	aorta smooth muscle tissue morphogenesis	GO:0060414	9.61	MIR145 MIR143
19	positive regulation of metalloendopeptidase activity	GO:1904685	9.61	MIR21 MIR17
20	negative regulation of interleukin-21 production	GO:0032705	9.58	MIR21 MIR221
21	regulation of phenotypic switching	GO:1900239	9.57	MIR143 MIR145
22	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO:1903589	9.56	MIR23A MIR21 MIR126 MIR10B
23	positive regulation of pulmonary blood vessel remodeling	GO:1905111	9.55	MIR17 MIR143
24	positive regulation of blood vessel endothelial cell migration	GO:0043536	9.55	MIR31 MIR30A MIR221 MIR143 MIR126
25	positive regulation of cellular response to hypoxia	GO:1900039	9.54	MIR21 MIR145
26	negative regulation of leukocyte adhesion to vascular endothelial cell	GO:1904995	9.54	MIR31 MIR221 MIR125A
27	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.5	MIR10B MIR126 MIR145 MIR17 MIR21 MIR221
28	establishment or maintenance of cell type involved in phenotypic switching	GO:0044663	9.49	MIR145 MIR143
29	negative regulation of interleukin-16 production	GO:0032699	9.48	MIR145 MIR125A

Molecular functions related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.77	MIR501 MIR31 MIR30A MIR23A MIR21 MIR199A1
2	mRNA base-pairing translational repressor activity	GO:1903231	9.5	MIR501 MIR31 MIR30A MIR23A MIR221 MIR21

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Sources for Malignant Exocrine Pancreas Neoplasm

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⁵³ Novoseek

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⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

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⁶⁸ SNOMED-CT

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⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MLG168 MIFTS: 27	Malignant Exocrine Pancreas Neoplasm Categories: Cancer diseases, Endocrine diseases	Data Licensing For inquiries, contact: [email protected]
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