MCID: MLG168
MIFTS: 27

Malignant Exocrine Pancreas Neoplasm

Categories: Cancer diseases, Endocrine diseases
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Aliases & Classifications for Malignant Exocrine Pancreas Neoplasm

MalaCards integrated aliases for Malignant Exocrine Pancreas Neoplasm:

Name: Malignant Exocrine Pancreas Neoplasm 11 14
Malignant Neoplasm of the Exocrine Pancreas 11
Malignant Tumour of Exocrine Pancreas 11
Malignant Tumor of Exocrine Pancreas 11

Classifications:



External Ids:

Disease Ontology 11 DOID:1795
NCIt 49 C7430
SNOMED-CT 68 255088001
UMLS 71 C0346648

Summaries for Malignant Exocrine Pancreas Neoplasm

Disease Ontology: 11 A pancreatic cancer that arises from the epithelial cells of the exocrine pancreatic tissue.

MalaCards based summary: Malignant Exocrine Pancreas Neoplasm, also known as malignant neoplasm of the exocrine pancreas, is related to glioma and bacterial infectious disease. An important gene associated with Malignant Exocrine Pancreas Neoplasm is MIR21 (MicroRNA 21), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. Affiliated tissues include pancreas.

Related Diseases for Malignant Exocrine Pancreas Neoplasm

Diseases in the Benign Exocrine Pancreas Neoplasm family:

Malignant Exocrine Pancreas Neoplasm

Diseases related to Malignant Exocrine Pancreas Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 316)
# Related Disease Score Top Affiliating Genes
1 glioma 10.6 MIR221 MIR21 MIR17 MIR10B
2 bacterial infectious disease 10.6 MIR21 ICOSLG H2AC18 CCR6
3 cystadenocarcinoma 10.6 MIR30A MIR21 MIR199A1
4 serous cystadenocarcinoma 10.5 MIR30A MIR21 MIR199A1 H2AC18
5 papillary adenocarcinoma 10.5 MIR30A MIR221 MIR21 MIR10B
6 ovarian clear cell carcinoma 10.5 MIR221 MIR21 MIR199A1 H2AC18
7 ovarian cystadenocarcinoma 10.5 MIR30A MIR196A1 MIR17 ICOSLG H2AC18
8 peripheral artery disease 10.5 MIR21 MIR199A1 MIR17 MIR126
9 ovary adenocarcinoma 10.5 MIR30A MIR196A1 MIR17 ICOSLG H2AC18
10 cystic echinococcosis 10.5 MIR30A MIR21 H2AC18
11 ovarian serous cystadenocarcinoma 10.5 MIR30A MIR196A1 MIR17 ICOSLG H2AC18
12 oropharynx cancer 10.5 MIR21 MIR199A1 MIR196A1 H2AC18
13 parasitic helminthiasis infectious disease 10.5 MIR21 ICOSLG H2AC18 CCR6
14 bone deterioration disease 10.5 MIR21 MIR17 MIR143 MIR126
15 intermediate coronary syndrome 10.5 MIR21 MIR17 MIR145 MIR142 MIR126
16 pre-malignant neoplasm 10.5 MIR30A MIR17 MIR142 H2AC18 CCR6
17 blood protein disease 10.5 MIR126 ICOSLG H2AC18 CCR6
18 aortic valve disease 2 10.5 MIR21 MIR199A1 MIR17 MIR126 H2AC18
19 polymyositis 10.5 MIR501 MIR30A MIR221 MIR21
20 dermatomyositis 10.5 MIR501 MIR30A MIR221 MIR21
21 autoimmune disease of exocrine system 10.5 MIR142 ICOSLG H2AC18 CCR6
22 primary cutaneous t-cell non-hodgkin lymphoma 10.5 MIR21 MIR17 H2AC18 CCR6
23 listeriosis 10.5 MIR125A ICOSLG H2AC18 CCR6
24 lymph node disease 10.5 MIR145 ICOSLG H2AC18 CCR6
25 coronavirus infectious disease 10.5 MIR21 ICOSLG H2AC18 CCR6
26 vascular disease 10.5 MIR21 MIR199A1 MIR145 MIR143 MIR126 MIR125A
27 lichen disease 10.5 MIR31 MIR142 ICOSLG CCR6
28 respiratory allergy 10.5 MIR21 MIR142 ICOSLG CCR6
29 cervix small cell carcinoma 10.5 MIR199A1 MIR145 MIR143 MIR10B
30 rectal benign neoplasm 10.5 MIR31 MIR17 MIR145 MIR143
31 mature t-cell and nk-cell lymphoma 10.5 MIR21 MIR199A1 MIR17 ICOSLG H2AC18 CCR6
32 adult t-cell leukemia/lymphoma 10.5 MIR142 ICOSLG H2AC18 CCR6
33 esophagus adenocarcinoma 10.5 MIR21 MIR199A1 MIR196A1 MIR145 MIR143
34 aortic aneurysm, familial abdominal, 1 10.5 MIR21 MIR199A1 MIR126 H2AC18 CCR6
35 microvascular complications of diabetes 5 10.5 MIR30A MIR21 MIR199A1 MIR17 MIR126 H2AC18
36 large cell carcinoma 10.5 MIR31 MIR30A MIR17 MIR145 MIR126
37 intrahepatic cholangiocarcinoma 10.5 MIR199A1 MIR17 MIR142 MIR126 H2AC18
38 suppression of tumorigenicity 12 10.5 MIR30A MIR221 MIR145 ICOSLG H2AC18
39 chromosomal deletion syndrome 10.5 MIR21 MIR17 MIR142 ICOSLG H2AC18 CCR6
40 limb ischemia 10.5 MIR21 MIR17 MIR126
41 chronic fatigue syndrome 10.5 MIR142 MIR126 H2AC18 CCR6
42 cardiovascular organ benign neoplasm 10.5 MIR199A1 MIR17 MIR143 H2AC18 CCR6
43 peripheral t-cell lymphoma 10.5 MIR21 MIR199A1 MIR17 ICOSLG H2AC18 CCR6
44 skin melanoma 10.5 MIR21 MIR199A1 ICOSLG H2AC18 CCR6
45 autoimmune pancreatitis 10.5 MIR21 ICOSLG CCR6
46 autoimmune myocarditis 10.5 ICOSLG H2AC18 CCR6
47 alcohol use disorder 10.5 MIR199A1 MIR196A1 H2AC18 CCR6
48 non-alcoholic steatohepatitis 10.5 MIR21 MIR199A1 MIR142 CCR6
49 thyroid gland follicular carcinoma 10.5 MIR221 MIR199A1 MIR17 MIR125A
50 heart valve disease 10.5 MIR21 MIR199A1 MIR17 MIR142 MIR126 H2AC18

Graphical network of the top 20 diseases related to Malignant Exocrine Pancreas Neoplasm:



Diseases related to Malignant Exocrine Pancreas Neoplasm

Symptoms & Phenotypes for Malignant Exocrine Pancreas Neoplasm

Drugs & Therapeutics for Malignant Exocrine Pancreas Neoplasm

Search Clinical Trials, NIH Clinical Center for Malignant Exocrine Pancreas Neoplasm

Genetic Tests for Malignant Exocrine Pancreas Neoplasm

Anatomical Context for Malignant Exocrine Pancreas Neoplasm

Organs/tissues related to Malignant Exocrine Pancreas Neoplasm:

MalaCards : Pancreas

Publications for Malignant Exocrine Pancreas Neoplasm

Articles related to Malignant Exocrine Pancreas Neoplasm:

# Title Authors PMID Year
1
Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement: Two case reports and literature review. 62
28930825 2017
2
Extrapancreatic solid pseudopapillary tumors: A clinicopathological analysis of two cases. 62
27123293 2016

Variations for Malignant Exocrine Pancreas Neoplasm

Expression for Malignant Exocrine Pancreas Neoplasm

Search GEO for disease gene expression data for Malignant Exocrine Pancreas Neoplasm.

Pathways for Malignant Exocrine Pancreas Neoplasm

Pathways related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.25 MIR21 MIR199A1 MIR145 MIR126
2
Show member pathways
11.25 MIR221 MIR199A1 MIR17 MIR145 MIR143
3 10.93 MIR23A MIR221 MIR21 MIR17 MIR145 MIR143

GO Terms for Malignant Exocrine Pancreas Neoplasm

Cellular components related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.97 MIR501 MIR31 MIR30A MIR23A MIR221 MIR21
2 RISC complex GO:0016442 9.84 MIR10B MIR125A MIR126 MIR142 MIR143 MIR145
3 extracellular vesicle GO:1903561 9.5 MIR30A MIR23A MIR221 MIR21 MIR17 MIR126

Biological processes related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell migration GO:0030336 9.94 MIR31 MIR21 MIR145 MIR126
2 negative regulation of angiogenesis GO:0016525 9.9 MIR21 MIR145 MIR143 MIR125A
3 positive regulation of angiogenesis GO:0045766 9.88 MIR126 MIR143 MIR199A1 MIR21 MIR30A MIR31
4 positive regulation of protein kinase B signaling GO:0051897 9.85 MIR221 MIR21 MIR199A1 MIR143 MIR126
5 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 9.8 MIR221 MIR21 MIR17
6 negative regulation of inflammatory response GO:0050728 9.8 MIR31 MIR221 MIR199A1 MIR145 MIR142 MIR126
7 miRNA-mediated gene silencing GO:0035195 9.8 MIR10B MIR125A MIR126 MIR142 MIR143 MIR145
8 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.77 MIR221 MIR199A1 MIR196A1
9 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.76 MIR21 MIR199A1 MIR145
10 positive regulation of sprouting angiogenesis GO:1903672 9.73 MIR31 MIR126 MIR125A
11 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.73 MIR31 MIR23A MIR126 MIR10B
12 positive regulation of vascular associated smooth muscle cell migration GO:1904754 9.7 MIR221 MIR21 MIR143
13 negative regulation of vascular endothelial growth factor production GO:1904046 9.69 MIR199A1 MIR17 MIR125A
14 cell growth involved in cardiac muscle cell development GO:0061049 9.64 MIR23A MIR199A1
15 angiotensin-activated signaling pathway GO:0038166 9.63 MIR145 MIR143
16 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.62 MIR199A1 MIR17
17 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.62 MIR21 MIR17
18 aorta smooth muscle tissue morphogenesis GO:0060414 9.61 MIR145 MIR143
19 positive regulation of metalloendopeptidase activity GO:1904685 9.61 MIR21 MIR17
20 negative regulation of interleukin-21 production GO:0032705 9.58 MIR21 MIR221
21 regulation of phenotypic switching GO:1900239 9.57 MIR143 MIR145
22 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.56 MIR23A MIR21 MIR126 MIR10B
23 positive regulation of pulmonary blood vessel remodeling GO:1905111 9.55 MIR17 MIR143
24 positive regulation of blood vessel endothelial cell migration GO:0043536 9.55 MIR31 MIR30A MIR221 MIR143 MIR126
25 positive regulation of cellular response to hypoxia GO:1900039 9.54 MIR21 MIR145
26 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.54 MIR31 MIR221 MIR125A
27 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.5 MIR10B MIR126 MIR145 MIR17 MIR21 MIR221
28 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.49 MIR145 MIR143
29 negative regulation of interleukin-16 production GO:0032699 9.48 MIR145 MIR125A

Molecular functions related to Malignant Exocrine Pancreas Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.77 MIR501 MIR31 MIR30A MIR23A MIR21 MIR199A1
2 mRNA base-pairing translational repressor activity GO:1903231 9.5 MIR501 MIR31 MIR30A MIR23A MIR221 MIR21

Sources for Malignant Exocrine Pancreas Neoplasm

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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