MCID: MLG014
MIFTS: 31

Malignant Fibrous Histiocytoma of Bone

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Malignant Fibrous Histiocytoma of Bone

MalaCards integrated aliases for Malignant Fibrous Histiocytoma of Bone:

Name: Malignant Fibrous Histiocytoma of Bone 12 15
Malignant Fibrous Histiocytoma of the Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3352
NCIt 50 C8563
UMLS 70 C0740479

Summaries for Malignant Fibrous Histiocytoma of Bone

MalaCards based summary : Malignant Fibrous Histiocytoma of Bone, also known as malignant fibrous histiocytoma of the bone, is related to fibrous histiocytoma and malignant fibrous histiocytoma. An important gene associated with Malignant Fibrous Histiocytoma of Bone is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Doxorubicin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include bone and smooth muscle.

Related Diseases for Malignant Fibrous Histiocytoma of Bone

Diseases related to Malignant Fibrous Histiocytoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 fibrous histiocytoma 31.9 SERPINA3 DES
2 malignant fibrous histiocytoma 31.6 SERPINA3 MYOD1 DES
3 benign giant cell tumor 30.5 SERPINA3 DES
4 leiomyosarcoma 30.4 SERPINA3 DES
5 hemangiopericytoma, malignant 29.7 SERPINA3 DES CALD1
6 spindle cell sarcoma 29.7 SERPINA3 DES CALD1
7 osteogenic sarcoma 10.8
8 fibrosarcoma 10.6
9 mammary paget's disease 10.4
10 osteomyelitis 10.4
11 fibrosarcoma of bone 10.4
12 bone sarcoma 10.3
13 malignant giant cell tumor 10.3
14 primary bone cancer 10.3
15 rare tumor 10.3
16 embryonal rhabdomyosarcoma 10.2 MYOD1 DES
17 gallbladder sarcoma 10.2 MYOD1 DES
18 malignant triton tumor 10.2 MYOD1 DES
19 botryoid rhabdomyosarcoma 10.2 MYOD1 DES
20 undifferentiated embryonal sarcoma of the liver 10.2 SERPINA3 MYOD1
21 bone cancer 10.2
22 soft tissue sarcoma 10.2
23 fibroma 10.2 SERPINA3 DES
24 spindle cell rhabdomyosarcoma 10.2 MYOD1 DES
25 congenital epulis 10.1 SERPINA3 DES
26 epulis 10.1 SERPINA3 DES
27 mesenchymal chondrosarcoma 10.1 MYOD1 DES
28 syringocystadenoma papilliferum 10.1 SERPINA3 DES
29 retinoblastoma 10.1
30 reticulum cell sarcoma 10.1
31 osteoblastoma 10.1
32 bone disease 10.1
33 fibrous dysplasia 10.1
34 myoepithelioma 10.1
35 bone giant cell tumor 10.1
36 bilateral retinoblastoma 10.1
37 fibrosarcomatous osteosarcoma 10.1
38 neurofibromatosis 10.1
39 solitary bone cyst 10.1
40 gas gangrene 10.1 SERPINA3 MYOD1
41 adenosarcoma 10.1 SERPINA3 DES
42 non-langerhans-cell histiocytosis 10.1 SERPINA3 DES
43 epithelioid leiomyosarcoma 10.1 SERPINA3 DES
44 pericoronitis 10.1 PAF1 DES
45 congenital fibrosarcoma 10.1 SERPINA3 DES
46 desmoplastic small round cell tumor 10.1 MYOD1 DES
47 cutaneous fibrous histiocytoma 10.1 SERPINA3 DES
48 granular cell tumor 10.1 SERPINA3 DES
49 alveolar soft part sarcoma 10.0 MYOD1 DES
50 rhabdomyosarcoma 2 10.0 MYOD1 DES

Graphical network of the top 20 diseases related to Malignant Fibrous Histiocytoma of Bone:



Diseases related to Malignant Fibrous Histiocytoma of Bone

Symptoms & Phenotypes for Malignant Fibrous Histiocytoma of Bone

Drugs & Therapeutics for Malignant Fibrous Histiocytoma of Bone

Drugs for Malignant Fibrous Histiocytoma of Bone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
4
Epirubicin Approved Phase 3 56420-45-2 41867
5
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
6
Ifosfamide Approved Phase 3 3778-73-2 3690
7
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
8
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
9
Liposomal doxorubicin Phase 3 31703
10 Immunosuppressive Agents Phase 3
11 Tubulin Modulators Phase 3
12 Antibiotics, Antitubercular Phase 3
13 Alkylating Agents Phase 3
14 Anti-Infective Agents Phase 3
15 Antirheumatic Agents Phase 3
16 Immunologic Factors Phase 3
17 Etoposide phosphate Phase 3
18 Anti-Bacterial Agents Phase 3
19
Isophosphamide mustard Phase 3 100427
20 Antimitotic Agents Phase 3
21
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
22 Imatinib Mesylate Phase 2 220127-57-1 123596
23 Protein Kinase Inhibitors Phase 2
24 Angiogenesis Inhibitors Phase 2
25
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
26 Analgesics, Non-Narcotic Phase 1
27 Cyclooxygenase 2 Inhibitors Phase 1
28 Analgesics Phase 1
29 Cyclooxygenase Inhibitors Phase 1
30 Anti-Inflammatory Agents Phase 1
31 Anti-Inflammatory Agents, Non-Steroidal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 MMT 95 Study For Rhabdomyosarcoma and Other Malignant Soft Tissue Tumors of Childhood Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Phase II Trial of Gleevec (Formerly Known as STI571) in Patients With Soft Tissue and Bone Sarcomas: A Multi-Disciplinary Trial of the North American Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00031915 Phase 2 imatinib mesylate
4 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
5 A Phase I Trial of Postoperative Radiation With Dose-Escalation of A Cox-2 Inhibitor, Celebrex™ (CELECOXIB) in Patients With Soft Tissue Sarcoma of the Extremity Completed NCT00450736 Phase 1 celecoxib
6 Genetic Study of Patients and Families With Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma of the Bone Completed NCT00007046
7 Prevention of Mucositis in Children With AES-14 (IND#36978), a Glutamine Based Oral Care Regimen, for Patients Diagnosed With Solid Tumors: A Randomized Placebo-Controlled Clinical Study Withdrawn NCT00334984 glutamine

Search NIH Clinical Center for Malignant Fibrous Histiocytoma of Bone

Genetic Tests for Malignant Fibrous Histiocytoma of Bone

Anatomical Context for Malignant Fibrous Histiocytoma of Bone

MalaCards organs/tissues related to Malignant Fibrous Histiocytoma of Bone:

40
Bone, Smooth Muscle

Publications for Malignant Fibrous Histiocytoma of Bone

Articles related to Malignant Fibrous Histiocytoma of Bone:

(show top 50) (show all 156)
# Title Authors PMID Year
1
Malignant fibrous histiocytoma of bone: A survival analysis from the National Cancer Database. 61
32133661 2020
2
Clinicopathological characteristics and survival of malignant fibrous histiocytoma of the bone: A population-based study using the SEER database. 61
32492019 2020
3
Ultra-short stem anchorage in the proximal tibial epiphysis after intercalary tumor resections: analysis of reconstruction survival in four patients at a mean follow-up of 56 months. 61
28213847 2017
4
Low-grade central osteosarcoma arising from bone infarct. 61
23375641 2013
5
The outcomes of navigation-assisted bone tumour surgery: minimum three-year follow-up. 61
23015571 2012
6
Smooth muscle actin expression in primary bone tumours. 61
22543453 2012
7
[Primary malignant bone tumors]. 61
22130624 2011
8
Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features. 61
22588017 2011
9
[An analysis of prognostic factors for malignant fibrous histiocytoma of bone]. 61
22168940 2011
10
MFH of bone and osteosarcoma show similar survival and chemosensitivity. 61
20559764 2011
11
Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone. 61
19936744 2010
12
Scalp metastasis from malignant fibrous histiocytoma of bone. 61
19119134 2008
13
Intraarterial chemotherapy for extremity osteosarcoma and MFH in adults. 61
18437502 2008
14
Limb salvage surgery complimented by customised mega prostheses for malignant fibrous histiocytomas of bone. 61
18162685 2007
15
[Preoperative adjuvant therapy for primary malignant bone tumors]. 61
18030009 2007
16
[Radiological characteristics of malignant fibrous histiocytoma of bone]. 61
17524338 2007
17
An uncommon presentation of malignant fibrous histiocytoma of the calcaneus. 61
17507531 2007
18
The role of radiation treatment in the contemporary management of bone tumors. 61
17442236 2007
19
Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry. 61
16630715 2006
20
[Pathologic and X-ray features of primary malignant fibrous histiocytoma of bone--a report of 16 cases]. 61
16687085 2006
21
Diaphyseal medullary stenosis with pleomorphic malignant fibrous histiocytoma of the bone: 99mTc hydroxymethylenediphosphonate and 201Tl chloride scintigraphy findings. 61
16715956 2006
22
[Radiological diagnosis of primary malignant fibrous histiocytoma of bone]. 61
16548202 2006
23
CASE REPORTS: malignant fibrous histiocytoma of bone arising in chronic osteomyelitis. 61
16205169 2005
24
[Value of imaging in the diagnosis of primary malignant fibrous histiocytoma of bone]. 61
16117901 2005
25
Malignant fibrous histiocytoma of bone associated with type-1 neurofibromatosis. A case report. 61
15687166 2005
26
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. 61
15540465 2004
27
A Phase II Study of Docetaxel for the Treatment of Recurrent Osteosarcoma. 61
18521398 2004
28
A ten-year-old boy with a pulmonary nodule secondary to Cryptococcus neoformans: case report and review of the literature. 61
14688572 2003
29
Benign fibrous histiocytoma: report of case. 61
12761591 2003
30
[The role of radiotherapy in the treatment of bone neoplasms]. 61
12491046 2002
31
Frequent expression of smooth muscle markers in malignant fibrous histiocytoma of bone. 61
12401825 2002
32
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. 61
12181274 2002
33
Establishment and characterization of a cell line from a malignant fibrous histiocytoma of bone developing in a patient with multiple fibrous dysplasia. 61
11862471 2002
34
Fibronexus in "malignant fibrous histiocytoma" of the bone: a case report of pleomorphic myofibrosarcoma. 61
12028659 2002
35
Detection of c-fos expression in benign and malignant musculoskeletal lesions. 61
11398843 2001
36
[Malignant fibrous histiocytoma of bone 20 years after femoral fracture treated by plate-screw fixation: analysis of corrosion products and their role in malignancy]. 61
11240542 2001
37
Malignant fibrous histocytoma of bone in neurofibromatosis--a case report. 61
12561999 2001
38
[Pathological fracture in primary malignant bone tumors]. 61
11043130 2000
39
h-Caldesmon as a specific marker for smooth muscle tumors. Comparison with other smooth muscle markers in bone tumors. 61
10800398 2000
40
Primary fibrosarcoma and malignant fibrous histiocytoma of bone--a comparative ultrastructural study: evidence of a spectrum of fibroblastic differentiation. 61
10808553 2000
41
Cerebral metastases from malignant fibrous histiocytoma of bone. 61
18521291 2000
42
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. 61
10642003 2000
43
Pathology of radium-induced bone tumors: new aspects of histopathology and histogenesis. 61
10564927 1999
44
Neoadjuvant chemotherapy with doxorubicin and cisplatin in malignant fibrous histiocytoma of bone: A European Osteosarcoma Intergroup study. 61
10506628 1999
45
Reconstruction and limb salvage after resection for malignant bone tumour of the proximal humerus. A sling procedure using a free vascularised fibular graft. 61
10530841 1999
46
Malignant fibrous histiocytoma of bone: a retrospective EMSOS study of 125 cases. European Musculo-Skeletal Oncology Society. 61
10569265 1999
47
Malignant fibrous histiocytoma of bone: conventional X-ray and MR imaging features. 61
9840391 1998
48
Malignant fibrous histiocytoma of bone: a clinicopathologic study of 81 patients. 61
9486593 1998
49
Neoadjuvant chemotherapy for high grade malignant fibrous histiocytoma of bone. 61
9577426 1998
50
[The effects of high-dose ifosfamide in the treatment of bone and soft tissue sarcomas]. 61
9388523 1997

Variations for Malignant Fibrous Histiocytoma of Bone

Expression for Malignant Fibrous Histiocytoma of Bone

Search GEO for disease gene expression data for Malignant Fibrous Histiocytoma of Bone.

Pathways for Malignant Fibrous Histiocytoma of Bone

Pathways related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.61 PAF1 LEO1 CTR9
2 11.13 MYOD1 DES
3
Show member pathways
11.06 PAF1 LEO1 CTR9

GO Terms for Malignant Fibrous Histiocytoma of Bone

Cellular components related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myofibril GO:0030016 9.16 MYOD1 CALD1
2 transcriptionally active chromatin GO:0035327 8.96 PAF1 CTR9
3 Cdc73/Paf1 complex GO:0016593 8.8 PAF1 LEO1 CTR9

Biological processes related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 Wnt signaling pathway GO:0016055 9.65 PAF1 LEO1 CTR9
2 transcription by RNA polymerase II GO:0006366 9.63 PAF1 LEO1 CTR9
3 transcription elongation from RNA polymerase II promoter GO:0006368 9.58 PAF1 LEO1 CTR9
4 stem cell population maintenance GO:0019827 9.54 PAF1 LEO1 CTR9
5 negative regulation of myeloid cell differentiation GO:0045638 9.5 PAF1 LEO1 CTR9
6 mRNA polyadenylation GO:0006378 9.49 PAF1 LEO1
7 positive regulation of mRNA 3'-end processing GO:0031442 9.43 PAF1 LEO1
8 histone monoubiquitination GO:0010390 9.43 PAF1 LEO1 CTR9
9 histone modification GO:0016570 9.33 PAF1 LEO1 CTR9
10 histone H2B ubiquitination GO:0033523 9.13 PAF1 LEO1 CTR9
11 endodermal cell fate commitment GO:0001711 8.8 PAF1 LEO1 CTR9

Molecular functions related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II complex binding GO:0000993 8.62 PAF1 CTR9

Sources for Malignant Fibrous Histiocytoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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