MCID: MLG014
MIFTS: 43

Malignant Fibrous Histiocytoma of Bone

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Malignant Fibrous Histiocytoma of Bone

MalaCards integrated aliases for Malignant Fibrous Histiocytoma of Bone:

Name: Malignant Fibrous Histiocytoma of Bone 12 15
Malignant Fibrous Histiocytoma of the Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3352
NCIt 50 C8563
UMLS 73 C0740479

Summaries for Malignant Fibrous Histiocytoma of Bone

MalaCards based summary : Malignant Fibrous Histiocytoma of Bone, also known as malignant fibrous histiocytoma of the bone, is related to histiocytoma and malignant fibroxanthoma. An important gene associated with Malignant Fibrous Histiocytoma of Bone is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Apoptosis Modulation and Signaling and Endometrial cancer. The drugs Doxorubicin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and brain, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Malignant Fibrous Histiocytoma of Bone

Diseases related to Malignant Fibrous Histiocytoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 31.8 CDK4 MDM2 MYOD1
2 malignant fibroxanthoma 31.4 CDK4 DES MDM2 MYOD1
3 fibrosarcoma of bone 28.0 CALD1 CDK4 MDM2 MYC PTER
4 fibrous histiocytoma 10.9
5 breast rhabdomyosarcoma 10.8 DES MYOD1
6 cervical polyp 10.8 DES MYOD1
7 botryoid rhabdomyosarcoma 10.8 DES MYOD1
8 gallbladder sarcoma 10.8 DES MYOD1
9 spindle cell rhabdomyosarcoma 10.7 DES MYOD1
10 horner's syndrome 10.7 DES MYOD1
11 ring chromosome 7 10.7 CDK4 MDM2
12 infiltrating angiolipoma 10.6 CDK4 MDM2
13 extraosseous osteosarcoma 10.6 CDK4 MDM2
14 pleomorphic liposarcoma 10.6 DES MDM2
15 bone osteosarcoma 10.6 CDK4 MDM2
16 lipoblastoma 10.6 CDK4 MDM2
17 mixed liposarcoma 10.6 CDK4 MDM2
18 malignant ectomesenchymoma 10.6 DES HRAS
19 periosteal chondrosarcoma 10.6 CDK4 MDM2
20 ectomesenchymoma 10.5 DES HRAS
21 atypical lipomatous tumor 10.5 CDK4 MDM2
22 well-differentiated liposarcoma 10.5 CDK4 MDM2
23 spindle cell sarcoma 10.5 DES MDM2
24 adult fibrosarcoma 10.5 HRAS MYOD1
25 chondroid lipoma 10.5 CDK4 MDM2
26 mesenchymoma 10.4 DES MDM2 MYOD1
27 infiltrating lipoma 10.4 CDK4 MDM2
28 rhabdoid cancer 10.4 DES MYOD1
29 undifferentiated embryonal sarcoma of the liver 10.4 CDK4 MDM2 MYOD1
30 spindle cell liposarcoma 10.4 CDK4 MDM2 MYOD1
31 spindle cell lipoma 10.4 CDK4 DES MDM2
32 ischemic fasciitis 10.4 CDK4 DES MDM2
33 pleomorphic lipoma 10.4 CDK4 MDM2
34 dedifferentiated liposarcoma 10.4 CDK4 DES MDM2
35 lipomatosis, multiple 10.4 CDK4 DES MDM2
36 leiomyosarcoma 10.3 CDK4 DES MDM2
37 conventional leiomyosarcoma 10.3 CALD1 MYOD1
38 liposarcoma 10.3 CDK4 DES MDM2
39 plasmablastic lymphoma 10.3 DES MYC
40 hemangiopericytoma, malignant 10.3 DES MDM2
41 conventional fibrosarcoma 10.3 CALD1 MDM2
42 juxtacortical osteosarcoma 10.3 CDK4 FOS MDM2
43 peripheral osteosarcoma 10.3 CDK4 FOS MDM2
44 medullomyoblastoma 10.2 DES MYC MYOD1
45 ovarian melanoma 10.1 CALD1 HRAS
46 holoprosencephaly 4 10.1 MYC PTER
47 pseudosarcomatous fibromatosis 10.1 CALD1 DES
48 skin melanoma 10.1 CDK4 HRAS MDM2
49 retinal cancer 10.1 CDK4 MDM2 MYC
50 inflammatory leiomyosarcoma 10.1 CALD1 DES MYOD1

Graphical network of the top 20 diseases related to Malignant Fibrous Histiocytoma of Bone:



Diseases related to Malignant Fibrous Histiocytoma of Bone

Symptoms & Phenotypes for Malignant Fibrous Histiocytoma of Bone

GenomeRNAi Phenotypes related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CDK4 DES HRAS MDM2 MYC TAGLN

MGI Mouse Phenotypes related to Malignant Fibrous Histiocytoma of Bone:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 CDK4 DES HRAS MDM2 MYC MYOD1
2 muscle MP:0005369 9.63 CDK4 DES MDM2 MYC MYOD1 TAGLN
3 neoplasm MP:0002006 9.5 CDK4 FOS HRAS MDM2 MYC MYOD1
4 normal MP:0002873 9.17 CDK4 FOS HRAS MDM2 MYC MYOD1

Drugs & Therapeutics for Malignant Fibrous Histiocytoma of Bone

Drugs for Malignant Fibrous Histiocytoma of Bone (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1 23214-92-8 31703
2
Ifosfamide Approved Phase 3,Phase 2 3778-73-2 3690
3
Mechlorethamine Approved, Investigational Phase 3,Phase 2 51-75-2 4033
4
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
5
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 50-18-0, 6055-19-2 2907
6
Dactinomycin Approved, Investigational Phase 3 50-76-0 2019 457193
7
Epirubicin Approved Phase 3 56420-45-2 41867
8
Etoposide Approved Phase 3 33419-42-0 36462
9
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
10
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1 31703
11 Alkylating Agents Phase 3,Phase 2
12 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
13 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
14 Antineoplastic Agents, Alkylating Phase 3,Phase 2
15
Isophosphamide mustard Phase 3,Phase 2 0
16 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
17 Anti-Infective Agents Phase 3,Phase 2
18 Antimitotic Agents Phase 3
19 Antineoplastic Agents, Phytogenic Phase 3
20 Antirheumatic Agents Phase 3,Phase 1
21 Etoposide phosphate Phase 3
22 Immunosuppressive Agents Phase 3,Phase 2
23 Nucleic Acid Synthesis Inhibitors Phase 3
24
Indinavir Approved Phase 2 150378-17-9 5362440
25
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
26
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
27 Anti-HIV Agents Phase 2
28 Anti-Retroviral Agents Phase 2
29 Antiviral Agents Phase 2
30 Cytochrome P-450 CYP3A Inhibitors Phase 2
31 Cytochrome P-450 Enzyme Inhibitors Phase 2
32 HIV Protease Inhibitors Phase 2
33 Liver Extracts Phase 2,Phase 1
34
protease inhibitors Phase 2
35 Imatinib Mesylate Phase 2 220127-57-1 123596
36 Protein Kinase Inhibitors Phase 2
37 Angiogenesis Inhibitors Phase 2
38 Angiogenesis Modulating Agents Phase 2
39 Cola Nutraceutical Phase 2,Phase 1
40
Celecoxib Approved, Investigational Phase 1 169590-42-5 2662
41 Analgesics Phase 1
42 Analgesics, Non-Narcotic Phase 1
43 Anti-Inflammatory Agents Phase 1
44 Anti-Inflammatory Agents, Non-Steroidal Phase 1
45 Cyclooxygenase 2 Inhibitors Phase 1
46 Cyclooxygenase Inhibitors Phase 1
47 Peripheral Nervous System Agents Phase 1
48 Interleukin-2 Phase 1
49 Vaccines Phase 1
50 Antibodies Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
4 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
5 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
6 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
7 Celecoxib and Radiation Therapy in Treating Patients With Stage II or Stage III Soft Tissue Sarcoma of the Arm, Hand, Leg, or Foot That Has Been Removed by Surgery Completed NCT00450736 Phase 1 celecoxib
8 Vaccine Therapy in Treating Patients With Metastatic Cancer Completed NCT00020267 Phase 1 interleukin-2;MAGE-12 peptide vaccine;Montanide ISA-51
9 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
10 Cixutumumab and Doxorubicin Hydrochloride in Treating Patients With Unresectable, Locally Advanced, or Metastatic Soft Tissue Sarcoma Completed NCT00720174 Phase 1 Doxorubicin Hydrochloride
11 Genetic Study of Patients and Families With Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma of the Bone Completed NCT00007046
12 Glutamine in Preventing Oral Mucositis in Patients Receiving Chemotherapy for Sarcoma Withdrawn NCT00334984 Not Applicable glutamine

Search NIH Clinical Center for Malignant Fibrous Histiocytoma of Bone

Genetic Tests for Malignant Fibrous Histiocytoma of Bone

Anatomical Context for Malignant Fibrous Histiocytoma of Bone

MalaCards organs/tissues related to Malignant Fibrous Histiocytoma of Bone:

41
Bone, Liver, Brain, Lung, Smooth Muscle

Publications for Malignant Fibrous Histiocytoma of Bone

Articles related to Malignant Fibrous Histiocytoma of Bone:

(show top 50) (show all 82)
# Title Authors Year
1
Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features. ( 22588017 )
2011
2
Imaging findings, prevalence and outcome of de novo and secondary malignant fibrous histiocytoma of bone. ( 19936744 )
2010
3
Scalp metastasis from malignant fibrous histiocytoma of bone. ( 19119134 )
2008
4
Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry. ( 16630715 )
2006
5
Malignant fibrous histiocytoma of bone associated with type-1 neurofibromatosis. A case report. ( 15687166 )
2005
6
CASE REPORTS: malignant fibrous histiocytoma of bone arising in chronic osteomyelitis. ( 16205169 )
2005
7
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. ( 15540465 )
2004
8
Frequent expression of smooth muscle markers in malignant fibrous histiocytoma of bone. ( 12401825 )
2002
9
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 years. ( 12181274 )
2002
10
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Health Professional Version ( 26389179 )
2002
11
Establishment and characterization of a cell line from a malignant fibrous histiocytoma of bone developing in a patient with multiple fibrous dysplasia. ( 11862471 )
2002
12
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Health Professional Version ( 27559573 )
2002
13
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Patient Version ( 27077200 )
2002
14
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Patient Version ( 26389380 )
2002
15
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Patient Version ( 26539616 )
2002
16
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Health Professional Version ( 27054239 )
2002
17
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Patient Version ( 27559594 )
2002
18
Osteosarcoma and Malignant Fibrous Histiocytoma of Bone Treatment (PDQAr): Health Professional Version ( 26447276 )
2002
19
Primary fibrosarcoma and malignant fibrous histiocytoma of bone--a comparative ultrastructural study: evidence of a spectrum of fibroblastic differentiation. ( 10808553 )
2000
20
Clinicopathologic features, diagnosis, and treatment of malignant fibrous histiocytoma of bone. ( 10642003 )
2000
21
Cerebral metastases from malignant fibrous histiocytoma of bone. ( 18521291 )
2000
22
Neoadjuvant chemotherapy with doxorubicin and cisplatin in malignant fibrous histiocytoma of bone: A European Osteosarcoma Intergroup study. ( 10506628 )
1999
23
Malignant fibrous histiocytoma of bone: a retrospective EMSOS study of 125 cases. European Musculo-Skeletal Oncology Society. ( 10569265 )
1999
24
Malignant fibrous histiocytoma of bone: conventional X-ray and MR imaging features. ( 9840391 )
1998
25
Malignant fibrous histiocytoma of bone: a clinicopathologic study of 81 patients. ( 9486593 )
1998
26
Neoadjuvant chemotherapy for high grade malignant fibrous histiocytoma of bone. ( 9577426 )
1998
27
Neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone and in osteosarcoma located in the extremities: analogies and differences between the two tumors. ( 9426330 )
1997
28
Malignant fibrous histiocytoma of bone. A clinicopathologic study of 81 patients. ( 9028358 )
1997
29
The value of high-dose methotrexate-based neoadjuvant chemotherapy in malignant fibrous histiocytoma of bone. ( 8636762 )
1996
30
Neoadjuvant chemotherapy for malignant fibrous histiocytoma of bone and for osteosarcoma of the limbs: a comparison between the results obtained for 21 and 144 patients, respectively, treated during the same period with the same chemotherapy protocol. ( 8968117 )
1996
31
Malignant fibrous histiocytoma of bone - Review of thirteen cases. ( 21594458 )
1996
32
Osteosarcoma versus malignant fibrous histiocytoma of bone in patients older than 40 years. A clinicopathologic and immunohistochemical analysis with special reference to malignant fibrous histiocytoma-like osteosarcoma. ( 8625223 )
1995
33
Multiple malignant fibrous histiocytoma of bone. A case report. ( 8197860 )
1994
34
Tumor progression in a giant cell type malignant fibrous histiocytoma of bone: clinical, radiologic, histologic, and cytogenetic evidence. ( 7519876 )
1994
35
Malignant fibrous histiocytoma of bone following primitive neuroectodermal tumor of bone. ( 8127258 )
1994
36
Malignant fibrous histiocytoma of bone: the experience of the New South Wales Bone Tumour Registry. ( 8386925 )
1993
37
Prognostic factors of malignant fibrous histiocytoma of bone. A clinical and histopathologic analysis of 34 cases. ( 8364866 )
1993
38
Chemotherapy of malignant fibrous histiocytoma of bone. ( 8394734 )
1993
39
Chromosome abnormalities in malignant fibrous histiocytoma of bone. ( 1664081 )
1991
40
Primary chemotherapy and delayed surgery for malignant fibrous histiocytoma of bone in the extremity. ( 2178284 )
1990
41
Malignant fibrous histiocytoma of bone. ( 2164619 )
1990
42
Intra-arterial cisplatinum and intravenous adriamycin in the treatment of osteosarcoma and malignant fibrous histiocytoma of bone: early surgical and clinical results. ( 2174327 )
1990
43
Cytogenetic findings in a primary malignant fibrous histiocytoma of bone and the lung metastasis. ( 2163505 )
1990
44
Multiple and familial malignant fibrous histiocytoma of bone. A report of two cases. ( 2154500 )
1990
45
Malignant fibrous histiocytoma of bone. ( 2536999 )
1989
46
Malignant fibrous histiocytoma of bone: initial diagnosis by aspiration biopsy cytology. ( 2855512 )
1988
47
Malignant fibrous histiocytoma of bone. ( 3006959 )
1986
48
Radiologic case study. Malignant fibrous histiocytoma of bone. ( 3014461 )
1986
49
Chemotherapy-induced complete remission of a malignant fibrous histiocytoma of bone. An 11-year follow-up. ( 3008679 )
1986
50
Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients. ( 3006524 )
1986

Variations for Malignant Fibrous Histiocytoma of Bone

Expression for Malignant Fibrous Histiocytoma of Bone

Search GEO for disease gene expression data for Malignant Fibrous Histiocytoma of Bone.

Pathways for Malignant Fibrous Histiocytoma of Bone

Pathways related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.66 FOS HRAS MDM2 MYC
2
Show member pathways
12.65 CDK4 FOS HRAS MDM2 MYC
3
Show member pathways
12.61 CDK4 FOS HRAS MDM2
4
Show member pathways
12.61 CDK4 FOS HRAS MYC
5 12.58 CDK4 FOS HRAS MDM2 MYC
6
Show member pathways
12.4 CDK4 FOS HRAS MYC
7
Show member pathways
12.36 FOS HRAS MDM2 MYC
8
Show member pathways
12.28 FOS HRAS MDM2 MYC
9 12.23 CDK4 FOS HRAS MYC
10 12.17 HRAS MDM2 MYC
11 12.16 CDK4 HRAS MDM2
12
Show member pathways
12.13 CDK4 FOS MDM2
13
Show member pathways
12.09 CDK4 FOS MYC
14
Show member pathways
12.08 FOS HRAS MDM2
15 12.01 CDK4 MDM2 MYC
16
Show member pathways
11.99 FOS HRAS MYC
17
Show member pathways
11.93 FOS HRAS MYC
18 11.93 CDK4 HRAS MDM2 MYC
19
Show member pathways
11.89 HRAS MDM2 MYC
20 11.87 CDK4 HRAS MDM2 MYC
21 11.86 CDK4 FOS MYC
22 11.84 HRAS MDM2 MYC
23 11.83 HRAS MDM2 MYC
24
Show member pathways
11.81 FOS HRAS MYC
25 11.73 FOS MYC MYOD1
26 11.68 CDK4 MDM2 MYC
27 11.64 BGLAP FOS MDM2
28 11.6 CDK4 HRAS MDM2 MYC
29 11.42 BGLAP MDM2 MYOD1
30 11.34 CDK4 FOS MYC MYOD1
31 11.27 CDK4 MDM2 MYC
32 11.23 HRAS MYC
33 11.22 CDK4 MDM2 MYC
34 11.21 FOS HRAS
35 11.2 CDK4 MDM2
36
Show member pathways
11.16 FOS HRAS
37 11.13 FOS MYC
38 11.12 CDK4 HRAS MDM2 MYC
39 11.09 CDK4 MYC
40 11.07 CDK4 FOS MYC
41 11.02 FOS HRAS
42 11 MDM2 MYC
43
Show member pathways
10.99 MDM2 MYC
44 10.88 FOS HRAS
45 10.76 CDK4 FOS HRAS MYC

GO Terms for Malignant Fibrous Histiocytoma of Bone

Cellular components related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.32 BGLAP CALD1 CDK4 DES FOS HRAS
2 transcription factor complex GO:0005667 9.13 CDK4 FOS MYOD1

Biological processes related to Malignant Fibrous Histiocytoma of Bone according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.76 CDK4 HRAS MDM2 MYC
2 regulation of gene expression GO:0010468 9.56 CDK4 MDM2 MYC MYOD1
3 response to toxic substance GO:0009636 9.54 CDK4 FOS MDM2
4 response to testosterone GO:0033574 9.51 BGLAP CDK4
5 cell aging GO:0007569 9.49 BGLAP HRAS
6 cellular response to gamma radiation GO:0071480 9.48 HRAS MDM2
7 negative regulation of cell cycle arrest GO:0071157 9.43 CDK4 MDM2
8 cellular response to estrogen stimulus GO:0071391 9.4 MDM2 MYC
9 response to gravity GO:0009629 9.32 BGLAP FOS
10 cellular response to phorbol 13-acetate 12-myristate GO:1904628 9.16 CDK4 MYC
11 positive regulation of cell cycle GO:0045787 9.13 CDK4 MDM2 MYC
12 response to drug GO:0042493 9.02 BGLAP CDK4 FOS MDM2 MYC

Sources for Malignant Fibrous Histiocytoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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