MFH
MCID: MLG065
MIFTS: 49

Malignant Fibroxanthoma (MFH)

Categories: Cancer diseases

Aliases & Classifications for Malignant Fibroxanthoma

MalaCards integrated aliases for Malignant Fibroxanthoma:

Name: Malignant Fibroxanthoma 12 15
Malignant Fibrous Histiocytoma 76 13 55 15 73
Histiocytoma, Fibrous, Malignant 40
Fibrous Histiocytoma, Malignant 12
Histiocytoma, Malignant Fibrous 44
Fibroxanthosarcoma 12
Mfh 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1907
MeSH 44 D051677
NCIt 50 C4247
SNOMED-CT 68 34360000
UMLS 73 C0334463

Summaries for Malignant Fibroxanthoma

MalaCards based summary : Malignant Fibroxanthoma, also known as malignant fibrous histiocytoma, is related to malignant fibrous histiocytoma of bone and myxofibrosarcoma. An important gene associated with Malignant Fibroxanthoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and Cytoskeletal Signaling. The drugs Mechlorethamine and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and liver, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Reduced mammosphere formation

Wikipedia : 76 Undifferentiated pleomorphic sarcoma (UPS), previously malignant fibrous histiocytoma (abbreviated MFH),... more...

Related Diseases for Malignant Fibroxanthoma

Diseases related to Malignant Fibroxanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 321)
# Related Disease Score Top Affiliating Genes
1 malignant fibrous histiocytoma of bone 33.9 CDK4 DES MDM2 MYOD1
2 myxofibrosarcoma 32.3 DES MKI67 S100B
3 fibrous histiocytoma 30.8 ACTC1 DES F13A1 S100B SERPINA3 VIM
4 liposarcoma 30.8 CDK4 DES MDM2 VIM
5 soft tissue sarcoma 30.5 MDM2 MKI67
6 histiocytosis 30.4 PTPRC S100B SERPINA3
7 dedifferentiated liposarcoma 30.3 ACTC1 CDK4 DES MDM2
8 fibrosarcoma of bone 30.2 CDK4 MDM2 SERPINA1 SERPINA3
9 inflammatory leiomyosarcoma 30.2 DES MYOD1
10 leiomyosarcoma 30.2 ACTC1 CDK4 DES MDM2 S100B VIM
11 congenital fibrosarcoma 30.1 ACTC1 DES VIM
12 chordoma 30.1 DES MUC1 S100B VIM
13 fibromatosis 30.1 ACTC1 DES VIM
14 histiocytoma 30.1 MDM2 MYOD1 PTPRC SERPINA3
15 undifferentiated embryonal sarcoma of the liver 30.0 CDK4 MDM2 MYOD1 SERPINA3
16 inflammatory mfh 30.0 CDK4 MDM2 SERPINA1 SERPINA3
17 dermatofibrosarcoma protuberans 29.9 ACTC1 DES F13A1 S100B SERPINA3 VIM
18 granular cell tumor 29.9 DES S100B SERPINA3 VIM
19 pleomorphic liposarcoma 29.8 DES MDM2 MUC1 S100B VIM
20 carcinosarcoma 29.8 ACTC1 DES MUC1 VIM
21 giant cell tumor 29.7 ACTC1 DES MUC1 PTPRC SERPINA3 VIM
22 gliosarcoma 29.7 ACTC1 CDK4 S100B VIM
23 medulloblastoma 29.7 ACTC1 CDK4 DES S100B
24 leiomyoma 29.6 ACTC1 DES MKI67 VIM
25 spindle cell sarcoma 29.6 ACTC1 DES MDM2 MUC1 S100B VIM
26 cutaneous fibrous histiocytoma 29.4 ACTC1 DES F13A1 S100B SERPINA3 VIM
27 rhabdomyosarcoma 29.4 ACTC1 CDK4 DES MDM2 MYOD1 PTPRC
28 inflammatory myofibroblastic tumor 29.4 ACTC1 CDK4 DES MDM2 S100B VIM
29 embryonal sarcoma 29.2 CDK4 DES MDM2 MKI67 MYOD1 S100B
30 undifferentiated pleomorphic sarcoma 11.7
31 malignant skin fibrous histiocytoma 11.5
32 histiocytoma, angiomatoid fibrous 11.3
33 urachal cancer 11.3
34 diaphyseal medullary stenosis with malignant fibrous histiocytoma 11.1
35 burn scar 10.4
36 lymphoma 10.4
37 osteomyelitis 10.4
38 intussusception 10.3
39 fibrous dysplasia 10.3
40 plasma protein metabolism disease 10.3 SERPINA1 SERPINA3
41 endodermal sinus tumor 10.3 SERPINA1 VIM
42 retinoblastoma 10.3
43 chondroid lipoma 10.3 CDK4 MDM2
44 small cell sarcoma 10.3 CDK4 MDM2
45 periosteal chondrosarcoma 10.3 CDK4 MDM2
46 infiltrating lipoma 10.3 CDK4 MDM2
47 periosteal osteogenic sarcoma 10.3 CDK4 MDM2
48 nodular tenosynovitis 10.3 PTPRC SERPINA3
49 epulis 10.2 DES VIM
50 infantile digital fibromatosis 10.2 DES VIM

Graphical network of the top 20 diseases related to Malignant Fibroxanthoma:



Diseases related to Malignant Fibroxanthoma

Symptoms & Phenotypes for Malignant Fibroxanthoma

GenomeRNAi Phenotypes related to Malignant Fibroxanthoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.26 CDK4 MUC1 PTPRC VIM
2 Reduced mammosphere formation GR00396-S 9.1 CDK4 DES F13A1 MDM2 PTPRC VIM

MGI Mouse Phenotypes related to Malignant Fibroxanthoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.86 ACTC1 CDK4 DES F13A1 LYZ MDM2
2 homeostasis/metabolism MP:0005376 9.85 ACTC1 CDK4 DES F13A1 LYZ MDM2
3 muscle MP:0005369 9.43 ACTC1 CDK4 DES MDM2 MYOD1 VIM
4 normal MP:0002873 9.23 ACTC1 CDK4 LYZ MDM2 MKI67 MYOD1

Drugs & Therapeutics for Malignant Fibroxanthoma

Drugs for Malignant Fibroxanthoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 51-75-2 4033
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1,Not Applicable 3778-73-2 3690
3
Doxorubicin Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 23214-92-8 31703
4
Dacarbazine Approved, Investigational Phase 3,Phase 2 4342-03-4 5351166
5
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
6
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
7
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
8
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
9
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
10
Epirubicin Approved Phase 3 56420-45-2 41867
11
Lenograstim Approved, Investigational Phase 3 135968-09-1
12
Trabectedin Approved, Investigational Phase 3,Phase 2 114899-77-3 108150
13
Docetaxel Approved, Investigational Phase 3,Phase 1,Phase 2 114977-28-5 148124
14
Gemcitabine Approved Phase 3,Phase 1,Phase 2 95058-81-4 60750
15 Olaratumab Approved, Investigational Phase 3,Phase 2 1024603-93-7
16
Doxil Approved June 1999 Phase 3,Phase 2,Phase 1,Not Applicable 31703
17
Isophosphamide mustard Phase 3,Phase 2,Phase 1,Not Applicable 0
18 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1,Not Applicable
19 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1,Not Applicable
20 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1,Not Applicable
21 Alkylating Agents Phase 3,Phase 2,Phase 1,Not Applicable
22 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
23 Anti-Infective Agents Phase 3,Phase 2,Phase 1
24 Antiviral Agents Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
26 Immunologic Factors Phase 3,Phase 1,Phase 2
27 Etoposide phosphate Phase 3,Phase 2
28 Antimitotic Agents Phase 3,Phase 2,Phase 1
29 Antirheumatic Agents Phase 3,Phase 2,Phase 1
30 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2
31 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
32 Antimetabolites Phase 3,Phase 1,Phase 2
33 Antimetabolites, Antineoplastic Phase 3,Phase 1,Phase 2
34
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
35
Indinavir Approved Phase 2 150378-17-9 5362440
36
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
37
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
38
Nicotinamide Approved, Investigational Phase 2 98-92-0 936
39
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
40
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
41
Sirolimus Approved, Investigational Phase 1, Phase 2,Phase 2 53123-88-9 46835353 6436030 5284616
42
Everolimus Approved Phase 1, Phase 2,Phase 2 159351-69-6 6442177
43
Miconazole Approved, Investigational, Vet_approved Phase 1, Phase 2,Phase 2 22916-47-8 4189
44
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
45
Pembrolizumab Approved Phase 1, Phase 2,Phase 2 1374853-91-4
46
Nivolumab Approved Phase 2,Phase 1 946414-94-4
47
Atezolizumab Approved, Investigational Phase 2 1380723-44-3
48
Mesna Approved, Investigational Phase 2,Not Applicable 3375-50-6 598
49
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
50
leucovorin Approved Phase 2 58-05-9 6006 143

Interventional clinical trials:

(show top 50) (show all 67)
# Name Status NCT ID Phase Drugs
1 Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
2 Surgery With or Without Radiation Therapy in Untreated Nonmetastatic Retroperitoneal Sarcoma Unknown status NCT01344018 Phase 3
3 Surgery Followed by Chemotherapy in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
4 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
5 Surgery With or Without Radiation Therapy in Treating Patients With Primary Soft Tissue Sarcoma of the Retroperitoneum or Pelvis Completed NCT00091351 Phase 3
6 Surgery With or Without Combination Chemotherapy in Treating Patients With Lung Metastases From Soft Tissue Sarcoma Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
7 Ifosfamide or Doxorubicin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
8 Doxorubicin With or Without Ifosfamide and Pegfilgrastim in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
9 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
10 Surgery With or Without Chemotherapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
11 Localized High-Risk Soft Tissue Sarcomas Of The Extremities And Trunk Wall In Adults: An Integrating Approach Comprising Standard Vs Histotype-Tailored Neoadjuvant Chemotherapy Recruiting NCT01710176 Phase 3 epirubicin 60 mg/m2/day (days 1, 2) and ifosfamide 3 g/m2/day (days 1, 2, 3);gemcitabine 900 mg/m2 (days 1 and 8) and docetaxel 75 mg/m2 (day 8);trabectedin 1.3 mg/m2;high-dose ifosfamide 14 g/m2, given in in 14 days;etoposide 150 mg/m2/day (days 1, 2, 3) and ifosfamide 3g/m2/day (days 1, 2, 3);gemcitabine 1800 mg/m2 (day 1) and dacarbazine 500 mg/m2 (day 1)
12 A Study of Doxorubicin Plus Olaratumab (LY3012207) in Participants With Advanced or Metastatic Soft Tissue Sarcoma Active, not recruiting NCT02451943 Phase 3 Olaratumab;Doxorubicin;Placebo
13 Randomised Trial of Volume of Post-operative Radiotherapy Given to Adult Patients With eXtremity Soft Tissue Sarcoma Active, not recruiting NCT00423618 Phase 3
14 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Suspended NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
15 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
16 External-Beam Radiation Therapy With or Without Indinavir and Ritonavir in Treating Patients With Brain Metastases Unknown status NCT00637637 Phase 2 indinavir sulfate;ritonavir
17 Brostallicin or Doxorubicin as First-Line Therapy in Treating Patients With Relapsed, Refractory, or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
18 Temozolomide in Treating Patients With Advanced Soft Tissue Sarcoma Unknown status NCT00003718 Phase 2 temozolomide
19 Phase II Study of Sunitinib Malate for Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma Completed NCT00400569 Phase 2 Sunitinib Malate (SU011248)
20 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate
21 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
22 Vismodegib and Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
23 Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lung Completed NCT00503295 Phase 2
24 Imatinib Mesylate in Treating Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans or Giant Cell Fibroblastoma Completed NCT00085475 Phase 2 imatinib mesylate
25 AZD0530 in Treating Patients With Recurrent Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2 saracatinib
26 Sorafenib in Treating Patients With Metastatic, Locally Advanced, or Recurrent Sarcoma Completed NCT00245102 Phase 2 sorafenib tosylate
27 Alisertib in Treating Patients With Advanced or Metastatic Sarcoma Completed NCT01653028 Phase 2 Alisertib
28 Depsipeptide (Romidepsin) in Treating Patients With Metastatic or Unresectable Soft Tissue Sarcoma Completed NCT00112463 Phase 2 romidepsin
29 Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent Sarcoma Completed NCT00949325 Phase 1, Phase 2 temsirolimus (Torisel) plus liposomal doxorubicin (Doxil)
30 Soblidotin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00064220 Phase 2 soblidotin
31 BI 2536 in Treating Patients With Recurrent or Metastatic Solid Tumors Completed NCT00526149 Phase 2 BI 2536
32 Ecteinascidin 743 in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00003939 Phase 2 trabectedin
33 STI571 in Treating Patients With Recurrent or Refractory Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
34 Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
35 Brostallicin in Treating Patients With Locally Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00041249 Phase 2 brostallicin
36 Exatecan Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma Completed NCT00041236 Phase 2 exatecan mesylate
37 Trial of Dasatinib in Advanced Sarcomas Completed NCT00464620 Phase 2 Dasatinib
38 Pembrolizumab and Gemcitabine Chemotherapy in Leiomyosarcoma and Undifferentiated Pleomorphic Sarcoma Recruiting NCT03123276 Phase 1, Phase 2 Pembrolizumab;Gemcitabine
39 Study of Neoadjuvant Checkpoint Blockade in Patients With Surgically Resectable Undifferentiated Pleomorphic Sarcoma and Dedifferentiated Liposarcoma Recruiting NCT03307616 Phase 2 Nivolumab;Ipilimumab
40 Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma Recruiting NCT03190174 Phase 1, Phase 2 Nab-Rapamycin
41 Clinical and Biological Activity of an Anti-PD-L1 (Atezolizumab) in Operable Localised Soft Tissue Sarcomas Patients to be Treated With Radiotherapy Recruiting NCT03474094 Phase 2
42 Multi-Arm Study to Test the Efficacy of Immunotherapeutic Agents in Multiple Sarcoma Subtypes Recruiting NCT02815995 Phase 2 Durvalumab;Tremelimumab
43 A Study of Epacadostat, an IDO1 Inhibitor, in Combination With Pembrolizumab in Patients With Metastatic and/or Locally Advanced Sarcoma Recruiting NCT03414229 Phase 2 Epacadostat;Pembrolizumab
44 Doxorubicin With Upfront Dexrazoxane Plus Olaratumab for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma Recruiting NCT02584309 Phase 2 Dexrazoxane;Doxorubicin;Olaratumab
45 Hypofractionated Radiotherapy With Sequential Chemotherapy in Primary Unresectable or Marginally Resectable Soft Tissue Sarcomas of Extremities or Trunk Wall Recruiting NCT03651375 Phase 2 Sequential chemotherapy - 3 courses of AI
46 Gemcitabine Hydrochloride With or Without Pazopanib Hydrochloride in Treating Patients With Refractory Soft Tissue Sarcoma Recruiting NCT01532687 Phase 2 Gemcitabine Hydrochloride;Pazopanib Hydrochloride
47 A Study of Bevacizumab in Combination With Chemotherapy for Treatment of Osteosarcoma Active, not recruiting NCT00667342 Phase 2 Cisplatin;Doxorubicin;Methotrexate;Ifosfamide;etoposide
48 Gemcitabine, Cisplatin, and Abraxane in Advanced Biliary Cancers Active, not recruiting NCT02392637 Phase 2 Abraxane (Nab-Paclitaxel);Cisplatin;Gemcitabine
49 Sapanisertib or Pazopanib Hydrochloride in Treating Patients With Locally Advanced or Metastatic Sarcoma Active, not recruiting NCT02601209 Phase 1, Phase 2 Pazopanib Hydrochloride;Sapanisertib
50 APX005M, Doxorubicin, Olaratumab in Advanced Sarcoma Not yet recruiting NCT03719430 Phase 2 Doxorubicin;Olaratumab;APX005M

Search NIH Clinical Center for Malignant Fibroxanthoma

Cochrane evidence based reviews: histiocytoma, malignant fibrous

Genetic Tests for Malignant Fibroxanthoma

Anatomical Context for Malignant Fibroxanthoma

MalaCards organs/tissues related to Malignant Fibroxanthoma:

41
Bone, Lung, Liver, Heart, Colon, Kidney, Spleen

Publications for Malignant Fibroxanthoma

Articles related to Malignant Fibroxanthoma:

(show top 50) (show all 1109)
# Title Authors Year
1
Giant malignant fibrous histiocytoma of the testis. ( 29484233 )
2018
2
Low-Grade Malignant Fibrous Histiocytoma Originating From the Medial Rectus Muscle. ( 29538190 )
2018
3
Primary Hepatic Malignant Fibrous Histiocytoma on PET/CT. ( 29485437 )
2018
4
Intracranial malignant fibrous histiocytoma. ( 29685317 )
2018
5
Splenic malignant fibrous histiocytoma with concurrent hypertension and epistaxis in an Alaskan malamute dog. ( 30103739 )
2018
6
The first ever reported case of malignant fibrous histiocytoma of the scalp. ( 30168269 )
2018
7
Treatment of spinal malignant fibrous histiocytoma, a case report and literature review. ( 30527900 )
2018
8
Treatment outcomes of malignant fibrous histiocytoma of the maxillary sinus. ( 28901310 )
2017
9
Malignant fibrous histiocytoma masquerading as pyogenic granuloma. ( 28388346 )
2017
10
Primary Pulmonary Malignant Fibrous Histiocytoma. ( 29404161 )
2017
11
Primary pulmonary malignant fibrous histiocytoma: case report and literature review. ( 28932590 )
2017
12
Malignant fibrous histiocytoma: Database review suggests a favorable prognosis in the head and neck. ( 28988458 )
2017
13
Malignant fibrous histiocytoma in the right portion of the mandible with metastasis in pancreas. ( 29040904 )
2017
14
Malignant fibrous histiocytoma arising from renal capsule: An extremely rare entity. ( 28937382 )
2017
15
En bloc resection and prosthesis implantation to treat malignant fibrous histiocytoma of the humerus. ( 29068573 )
2017
16
Primary hepatic malignant fibrous histiocytoma combined with invasion of inferior vena cava: A case report and literature review. ( 28591058 )
2017
17
Retrovesical malignant fibrous histiocytoma: a rare tumor. ( 29197849 )
2017
18
Dermoscopic findings in an early malignant fibrous histiocytoma on the face. ( 29085719 )
2017
19
A Rare Case of Malignant Fibrous Histiocytoma (Undifferentiated High-Grade Pleomorphic Sarcoma) of Malar Region. ( 28468216 )
2017
20
A Squamous Cell Carcinoma and a Malignant Fibrous Histiocytoma Developing in a Patient with a Mature Cystic Teratoma. ( 28203171 )
2017
21
Primary Malignant Fibrous Histiocytoma of the Thyroid: Two Case Reports and Review of the Literature. ( 28165628 )
2017
22
Malignant fibrous histiocytoma in a patient presenting with urinary system symptoms. ( 29451657 )
2017
23
Pleomorphic spindle cell sarcoma (PSCS) (formerly known as malignant fibrous histiocytoma, MFH) of the spleen, mimics an atypical haemangioma on 99mTc-RBC, CT and Ultrasound: staging with 18F-FDG PET/CT. ( 30363227 )
2017
24
Double primary malignant fibrous histiocytoma and squamous cell carcinoma of the larynx treated with laser laryngeal conservation surgery. ( 27170836 )
2016
25
Malignant Fibrous Histiocytoma of the Testicular Appendages Mimicking an Obstructed Hernia in an Elderly Man: Case Report and Review of the Literature. ( 26953736 )
2016
26
Primary malignant fibrous histiocytoma of long bones: long-term follow-up. ( 27499321 )
2016
27
An unresectable retroperitoneal malignant fibrous histiocytoma: A case report. ( 27073487 )
2016
28
A case of recurrent malignant fibrous histiocytoma of the mesentery. ( 27351621 )
2016
29
Malignant fibrous histiocytoma of the skin: a case treated with radiotherapy. ( 27176091 )
2016
30
Primary malignant fibrous histiocytoma of the colon: A case report and review of the literature. ( 27284436 )
2016
31
Malignant fibrous histiocytoma of the skin. A case treated with radiotherapy. ( 26837483 )
2016
32
Successful treatment of advanced malignant fibrous histiocytoma of the right forearm with apatinib: a case report. ( 26917971 )
2016
33
Computed tomography and magnetic resonance imaging findings of malignant fibrous histiocytoma of the head and neck. ( 27123302 )
2016
34
Primary malignant fibrous histiocytoma of the liver. ( 27826563 )
2016
35
Metastatic Malignant Fibrous Histiocytoma Infiltrating Sigmoid Colon: A Case Diagnosed With the Help of 18F-FDG PET/CT. ( 26673233 )
2016
36
Parasacral malignant fibrous histiocytoma presenting with low back pain. ( 26674443 )
2016
37
Effect of Non-Hodgkin Lymphoma on Survival in Patients With Malignant Fibrous Histiocytoma, Kaposi Sarcoma, and Sebaceous Carcinoma: A SEER Population-Based Study. ( 26730972 )
2016
38
Single nucleotide polymorphisms in the mitochondrial displacement loop region and outcome of malignant fibrous histiocytoma. ( 24491095 )
2016
39
A rare case of malignant fibrous histiocytoma/ pleomorphic undifferentiated sarcoma of the kidney. ( 25738036 )
2015
40
Retroperitoneal Cystic Malignant Fibrous Histiocytoma Mimicking a Psoas Abscess. ( 26557275 )
2015
41
Malignant fibrous histiocytoma: an uncommon sarcoma with pathological fracture of mandible. ( 25838711 )
2015
42
A rare case of malignant fibrous histiocytoma (pleomorphic undifferentiated sarcoma NOS) of the vocal fold. ( 26214667 )
2015
43
Recurrent Atypical Fibroxanthoma Versus Malignant Fibrous Histiocytoma. ( 26080249 )
2015
44
Giant cell variant of malignant fibrous histiocytoma of male breast: A rare case report. ( 26458656 )
2015
45
Intrascrotal paratesticular malignant fibrous histiocytoma-a rare case and its management. ( 26960520 )
2015
46
Metastatic Malignant Fibrous Histiocytoma in the Stomach: Imaging With 18F-FDG PET/CT. ( 26053714 )
2015
47
Reconstruction of the elbow by Baksi sloppy hinge total elbow prosthesis following excision of a malignant fibrous histiocytoma. ( 26566346 )
2015
48
Rat malignant fibrous histiocytoma (MFH)-derived cloned cell lines (MT-8 and MT-9) show different differentiation in mesenchymal stem cell lineage. ( 26208870 )
2015
49
En bloc spondylectomy for primary malignant fibrous histiocytoma of the thoracic spine with aortic involvement: case report. ( 25658464 )
2015
50
Malignant fibrous histiocytoma of visceral organs: clinicopathologic features and diagnostic value of ezrin and HMG-CoA reductase. ( 26045796 )
2015

Variations for Malignant Fibroxanthoma

Copy number variations for Malignant Fibroxanthoma from CNVD:

7 (show all 41)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 18958 1 148000000 153300000 Gain Malignant fibrous histiocytomas
2 27753 1 212100000 222100000 Loss Malignant fibrous histiocytomas
3 33593 1 46500000 56200000 Gain Malignant fibrous histiocytomas
4 35188 1 60900000 69500000 Gain Malignant fibrous histiocytomas
5 37769 1 94500000 99400000 Gain Malignant fibrous histiocytomas
6 39415 10 114900000 121700000 Loss Malignant fibrous histiocytomas
7 50207 11 115400000 134452384 Loss Malignant fibrous histiocytomas
8 59633 11 76700000 85300000 Loss Malignant fibrous histiocytomas
9 60562 11 87900000 96700000 Loss Malignant fibrous histiocytomas
10 69083 12 5300000 14800000 Gain Malignant fibrous histiocytomas
11 76673 13 34700000 48900000 Loss Malignant fibrous histiocytomas
12 78011 13 48900000 57600000 Loss Malignant fibrous histiocytomas
13 86677 14 64000000 88900000 Gain Malignant fibrous histiocytomas
14 88587 14 92800000 106368585 Gain Malignant fibrous histiocytomas
15 101715 16 45500000 54500000 Loss Malignant fibrous histiocytomas
16 103579 16 6300000 10300000 Loss Malignant fibrous histiocytomas
17 107007 17 11200000 15900000 Gain Malignant fibrous histiocytomas
18 107027 17 11200000 22100000 Gain Malignant fibrous histiocytomas
19 107535 17 15900000 22100000 Gain Malignant fibrous histiocytomas
20 112060 17 37800000 44800000 Gain Malignant fibrous histiocytomas
21 119810 18 17300000 23300000 Gain Malignant fibrous histiocytomas
22 122735 18 59800000 76117153 Loss Malignant fibrous histiocytomas
23 127802 19 37100000 47800000 Gain Malignant fibrous histiocytomas
24 134297 2 1 12800000 Loss Malignant fibrous histiocytomas
25 142547 2 225800000 237000000 Loss Malignant fibrous histiocytomas
26 154853 20 49200000 54400000 Gain Malignant fibrous histiocytomas
27 163375 22 27900000 35900000 Gain Malignant fibrous histiocytomas
28 163745 22 30500000 39300000 Gain Malignant fibrous histiocytomas
29 164763 22 39300000 49691432 Loss Malignant fibrous histiocytomas
30 178974 3 83700000 89400000 Gain Malignant fibrous histiocytomas
31 187572 4 52400000 59200000 Gain Malignant fibrous histiocytomas
32 192956 5 121500000 143100000 Loss Malignant fibrous histiocytomas
33 198017 5 18500000 23300000 Gain Malignant fibrous histiocytomas
34 214607 6 63500000 75900000 Gain Malignant fibrous histiocytomas
35 221899 7 147500000 158821424 Loss Malignant fibrous histiocytomas
36 225328 7 4500000 7200000 Gain Malignant fibrous histiocytomas
37 226671 7 61100000 71800000 Gain Malignant fibrous histiocytomas
38 237234 8 2200000 19100000 Loss Malignant fibrous histiocytomas
39 244141 8 93500000 99100000 Gain Malignant fibrous histiocytomas
40 250775 9 2200000 9000000 Loss Malignant fibrous histiocytomas
41 255895 9 86100000 113900000 Gain Malignant fibrous histiocytomas

Expression for Malignant Fibroxanthoma

Search GEO for disease gene expression data for Malignant Fibroxanthoma.

Pathways for Malignant Fibroxanthoma

Pathways related to Malignant Fibroxanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.57 F13A1 LYZ MDM2 MUC1 PTPRC S100B
2 11.95 ACTC1 DES MUC1 VIM
3 11.73 CDK4 MDM2 MKI67 VIM
4 11.49 F13A1 MUC1 VIM
5 10.66 ACTC1 DES VIM

GO Terms for Malignant Fibroxanthoma

Cellular components related to Malignant Fibroxanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 9.33 ACTC1 F13A1 SERPINA3
2 extracellular exosome GO:0070062 9.23 ACTC1 DES LYZ MUC1 PTPRC SERPINA1
3 platelet alpha granule lumen GO:0031093 9.13 F13A1 SERPINA1 SERPINA3

Biological processes related to Malignant Fibroxanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.33 F13A1 SERPINA1 SERPINA3
2 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
3 intermediate filament organization GO:0045109 9.26 DES VIM
4 regulation of gene expression GO:0010468 9.26 CDK4 MDM2 MYOD1 PTPRC
5 muscle filament sliding GO:0030049 8.8 ACTC1 DES VIM

Molecular functions related to Malignant Fibroxanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 DES LYZ MDM2 S100B SERPINA1 VIM

Sources for Malignant Fibroxanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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