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MCID: MLG066
MIFTS: 21

Malignant Gastric Germ Cell Tumor

Categories: Cancer diseases, Gastrointestinal diseases
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Aliases & Classifications for Malignant Gastric Germ Cell Tumor

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MalaCards integrated aliases for Malignant Gastric Germ Cell Tumor:

Name: Malignant Gastric Germ Cell Tumor 11 14 71
Malignant Gastric Germ Cell Tumour 11
Germ Cell Tumour of the Stomach 11
Germ Cell Tumor of the Stomach 11

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:4716
NCIt 49 C6448
UMLS 71 C1333769 C1334584
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Summaries for Malignant Gastric Germ Cell Tumor

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MalaCards based summary: Malignant Gastric Germ Cell Tumor, also known as malignant gastric germ cell tumour, is related to fetal and neonatal alloimmune thrombocytopenia and esophagus lymphoma. An important gene associated with Malignant Gastric Germ Cell Tumor is SNORA16A (Small Nucleolar RNA, H/ACA Box 16A), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and MAPK Signaling: Mitogens.
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Related Diseases for Malignant Gastric Germ Cell Tumor

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Diseases related to Malignant Gastric Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 fetal and neonatal alloimmune thrombocytopenia 10.1 ITGB3 ITGA2B
2 esophagus lymphoma 10.1 ALK AFP
3 bleeding disorder, platelet-type, 16 10.1 ITGB3 ITGA2B
4 autosomal dominant macrothrombocytopenia 10.1 ITGB3 ITGA2B
5 liver leiomyoma 10.1 ALK AFP
6 heparin-induced thrombocytopenia 10.1 ITGB3 ITGA2B
7 acquired thrombocytopenia 10.1 ITGB3 ITGA2B
8 bleeding disorder, platelet-type, 18 10.1 ITGB3 ITGA2B
9 thrombasthenia 10.0 ITGB3 ITGA2B
10 primary thrombocytopenia 10.0 ITGB3 ITGA2B
11 coronary thrombosis 10.0 ITGB3 ITGA2B
12 thrombocytopenia due to platelet alloimmunization 10.0 ITGB3 ITGA2B
13 fallopian tube clear cell adenocarcinoma 10.0 NTRK1 ITGB3
14 collecting duct carcinoma 10.0 CA9 ALK
15 acute erythroid leukemia 10.0 ITGA2B GYPA
16 malignant giant cell tumor of the tendon sheath 9.9 NTRK1 ALK
17 spitzoid melanoma 9.9 NTRK1 ALK
18 childhood fibrosarcoma 9.9 NTRK1 ALK
19 autonomic nervous system benign neoplasm 9.9 NTRK1 ALK
20 testicular torsion 9.9 MPO AFP
21 peripheral nervous system benign neoplasm 9.9 NTRK1 ALK
22 myelitis 9.9 ITGB3 ITGA2B
23 myeloproliferative syndrome, transient 9.9 ITGB3 ITGA2B GYPA
24 infantile myofibromatosis 9.9 NTRK1 ALK
25 congenital fibrosarcoma 9.9 NTRK1 ALK
26 differentiated thyroid carcinoma 9.9 NTRK1 ALK
27 appendix lymphoma 9.9 MPO ITGB3
28 thrombocytopenic purpura, autoimmune 9.9 ITGB3 ITGA2B
29 cecal disease 9.9 MPO AFP
30 congenital mesoblastic nephroma 9.9 NTRK1 ALK
31 ganglioneuroblastoma 9.8 NTRK1 ALK
32 infective endocarditis 9.8 MPO ITGA2B
33 mesenchymal cell neoplasm 9.8 NTRK1 ALK
34 autoimmune disease of blood 9.8 MPO ITGA2B
35 pericardium disease 9.8 MPO ALK
36 beta-thalassemia major 9.7 ITGA2B GYPA
37 blood coagulation disease 9.7 MPO ITGB3 ITGA2B
38 acute megakaryocytic leukemia 9.7 MPO ITGB3 ITGA2B
39 blood platelet disease 9.7 MPO ITGB3 ITGA2B
40 fibrosarcoma 9.7 NTRK1 CA9 ALK
41 exanthem 9.6 MPO ALK
42 leukemia, chronic myeloid 9.3 NTRK1 MPO ITGB3 ALK
43 malignant gastric teratoma 9.2 SNORA16A NTRK1 CA9 CA14 ALK AFP
44 leukemia, acute myeloid 8.9 NTRK1 MPO ITGB3 ITGA2B GYPA ALK
45 gastric teratoma 8.7 SNORA16A MPO ITGB3 ITGA2B GYPA CA9

Graphical network of the top 20 diseases related to Malignant Gastric Germ Cell Tumor:



Diseases related to Malignant Gastric Germ Cell Tumor
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Symptoms & Phenotypes for Malignant Gastric Germ Cell Tumor

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Drugs & Therapeutics for Malignant Gastric Germ Cell Tumor

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Search Clinical Trials, NIH Clinical Center for Malignant Gastric Germ Cell Tumor

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Genetic Tests for Malignant Gastric Germ Cell Tumor

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Anatomical Context for Malignant Gastric Germ Cell Tumor

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Publications for Malignant Gastric Germ Cell Tumor

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Articles related to Malignant Gastric Germ Cell Tumor:

# Title Authors PMID Year
1
Gastric immature teratoma arising from the lesser curvature of the stomach: A rare case report. 62
35381809 2022
2
Immature gastric teratoma in an infant: a case report and review of the literatures. 62
27761247 2016
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Variations for Malignant Gastric Germ Cell Tumor

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Expression for Malignant Gastric Germ Cell Tumor

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Search GEO for disease gene expression data for Malignant Gastric Germ Cell Tumor.
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Pathways for Malignant Gastric Germ Cell Tumor

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Pathways related to Malignant Gastric Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Actin Nucleation by ARP-WASP Complex 64
Show member pathways
 12.46 NTRK1 ITGB3 ITGA2B ALK
2
MAPK Signaling: Mitogens 65
Show member pathways
 11.86 NTRK1 ITGB3 ITGA2B
3
G-protein signaling RAC1 in cellular process 22
Show member pathways
 11.74 NTRK1 ITGB3 ITGA2B ALK
4
G-protein signaling_RhoA regulation pathway 22
11.4 NTRK1 ITGB3 ITGA2B
5
Platelet Aggregation Inhibitor Pathway, Pharmacodynamics 60
11.23 ITGB3 ITGA2B
6
Signaling events mediated by PTP1B 61
11.17 ITGB3 ITGA2B
7
Beta3 integrin cell surface interactions 61
11.07 ITGB3 ITGA2B
8
Heparin-induced Thrombocytopenia Pathway, Adverse Drug Reaction 60
11.02 ITGB3 ITGA2B
9
Hematopoietic Stem Cells and Lineage-specific Markers 65
10.99 MPO ITGB3 ITGA2B GYPA
10
Arf6 signaling events 61
10.94 ITGB3 ITGA2B
11
Signal transduction by L1 66
10.69 ITGB3 ITGA2B
12
G-protein signaling_Rap2B regulation pathway 22
10.61 NTRK1 ITGB3 ITGA2B ALK
13
Ephrin B reverse signaling 61
10.51 ITGB3 ITGA2B
14
Reversible hydration of carbon dioxide 66
10.03 CA9 CA14
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GO Terms for Malignant Gastric Germ Cell Tumor

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Cellular components related to Malignant Gastric Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microvillus membrane GO:0031528 9.46 ITGB3 CA9
2 integrin complex GO:0008305 9.26 ITGB3 ITGA2B
3 platelet alpha granule membrane GO:0031092 8.92 ITGB3 ITGA2B

Biological processes related to Malignant Gastric Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine autophosphorylation GO:0038083 8.92 NTRK1 ALK

Molecular functions related to Malignant Gastric Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydro-lyase activity GO:0016836 9.26 CA9 CA14
2 carbonate dehydratase activity GO:0004089 8.92 CA9 CA14
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Sources for Malignant Gastric Germ Cell Tumor

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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