Malignant Gastric Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Malignant Gastric Germ Cell Tumor

MalaCards integrated aliases for Malignant Gastric Germ Cell Tumor:

Name: Malignant Gastric Germ Cell Tumor ¹² ¹⁵ ⁷¹

Germ Cell Tumor of the Stomach ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Gastrointestinal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4716

NCIt ⁴⁹ C6448

UMLS ⁷¹ C1333769 C1334584

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Summaries for Malignant Gastric Germ Cell Tumor

MalaCards based summary : Malignant Gastric Germ Cell Tumor, also known as germ cell tumor of the stomach, is related to infected hydrocele and appendix lymphoma. An important gene associated with Malignant Gastric Germ Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Phagosome and Fluid shear stress and atherosclerosis. Affiliated tissues include myeloid and appendix.

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Related Diseases for Malignant Gastric Germ Cell Tumor

Diseases related to Malignant Gastric Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 26)

#	Related Disease	Score	Top Affiliating Genes
1	infected hydrocele	10.0	MPO AFP
2	appendix lymphoma	9.9	MPO ITGB3
3	alpha-1-antitrypsin deficiency	9.8	MPO AFP
4	fetal and neonatal alloimmune thrombocytopenia	9.7	ITGB3 ITGA2B
5	bleeding disorder, platelet-type, 16	9.7	ITGB3 ITGA2B
6	autosomal dominant macrothrombocytopenia	9.7	ITGB3 ITGA2B
7	thrombasthenia	9.6	ITGB3 ITGA2B
8	thrombocytopenia due to platelet alloimmunization	9.6	ITGB3 ITGA2B
9	primary thrombocytopenia	9.6	ITGB3 ITGA2B
10	autoimmune disease of blood	9.6	ITGB3 ITGA2B
11	coronary thrombosis	9.6	ITGB3 ITGA2B
12	inherited blood coagulation disease	9.6	ITGB3 ITGA2B
13	blood coagulation disease	9.6	ITGB3 ITGA2B
14	myeloproliferative syndrome, transient	9.6	ITGB3 ITGA2B
15	thrombocytopenic purpura, autoimmune	9.5	ITGB3 ITGA2B
16	purpura	9.5	ITGB3 ITGA2B
17	glanzmann thrombasthenia	9.4	ITGB3 ITGA2B
18	bernard-soulier syndrome	9.4	ITGB3 ITGA2B
19	megakaryocytic leukemia	9.3	MPO ITGB3 ITGA2B
20	essential thrombocythemia	9.3	MPO ITGB3 ITGA2B
21	aplastic anemia	9.2	MPO ITGB3 ITGA2B
22	blood platelet disease	9.2	ITGB3 ITGA2B
23	vascular disease	9.1	MPO ITGB3 ITGA2B
24	myelodysplastic syndrome	9.0	MPO ITGA2B GYPA
25	leukemia, acute myeloid	8.9	MPO ITGB3 ITGA2B GYPA
26	gastric teratoma	8.5	MPO ITGB3 ITGA2B GYPA AFP

Graphical network of the top 20 diseases related to Malignant Gastric Germ Cell Tumor:

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Symptoms & Phenotypes for Malignant Gastric Germ Cell Tumor

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Drugs & Therapeutics for Malignant Gastric Germ Cell Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Gastric Germ Cell Tumor

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Genetic Tests for Malignant Gastric Germ Cell Tumor

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Anatomical Context for Malignant Gastric Germ Cell Tumor

MalaCards organs/tissues related to Malignant Gastric Germ Cell Tumor:

⁴⁰

Myeloid, Appendix

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Publications for Malignant Gastric Germ Cell Tumor

Articles related to Malignant Gastric Germ Cell Tumor:

#	Title	Authors	PMID	Year
1	Immature gastric teratoma in an infant: a case report and review of the literatures. ⁶¹	Junhasavasdikul T...Larbcharoensub N	27761247	2016

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Genes for Malignant Gastric Germ Cell Tumor

Genes related to Malignant Gastric Germ Cell Tumor (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	AFP	Alpha Fetoprotein	Protein Coding	5.57	DISEASES inferred ¹⁵
2	GYPA	Glycophorin A (MNS Blood Group)	Protein Coding	4.94	DISEASES inferred ¹⁵
3	ITGB3	Integrin Subunit Beta 3	Protein Coding	4.61	DISEASES inferred ¹⁵
4	ITGA2B	Integrin Subunit Alpha 2b	Protein Coding	4.35	DISEASES inferred ¹⁵
5	MPO	Myeloperoxidase	Protein Coding	3.87	DISEASES inferred ¹⁵

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Variations for Malignant Gastric Germ Cell Tumor

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Expression for Malignant Gastric Germ Cell Tumor

Search GEO for disease gene expression data for Malignant Gastric Germ Cell Tumor.

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Pathways for Malignant Gastric Germ Cell Tumor

Pathways related to Malignant Gastric Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 17)

#	Super pathways	Score	Top Affiliating Genes
1	Phagosome ³⁶	11.75	MPO ITGB3
2	Fluid shear stress and atherosclerosis ³⁶	11.69	ITGB3 ITGA2B
3	Oncogenic MAPK signaling ⁶⁵ Show member pathways Signaling by BRAF and RAF fusions ⁶⁵	11.67	ITGB3 ITGA2B
4	L1CAM interactions ⁶⁵ Show member pathways CHL1 interactions ⁶⁵ Neurofascin interactions ⁶⁵ NrCAM interactions ⁶⁵	11.62	ITGB3 ITGA2B
5	Platelet activation ³⁶	11.6	ITGB3 ITGA2B
6	Reelin Pathway (Cajal-Retzius cells) ⁶³	11.56	ITGB3 ITGA2B
7	Integrin alphaIIb beta3 signaling ⁶⁵ Show member pathways GRB2-SOS provides linkage to MAPK signaling for Integrins ⁶⁵ p130Cas linkage to MAPK signaling for integrins ⁶⁵ Platelet Aggregation (Plug Formation) ⁶⁵	11.49	ITGB3 ITGA2B
8	Phagocytosis of Microbes ⁶³	11.41	ITGB3 ITGA2B
9	Hematopoietic cell lineage ³⁶	11.33	ITGB3 ITGA2B GYPA
10	ECM proteoglycans ⁶⁵	11.21	ITGB3 ITGA2B
11	Platelet Aggregation Inhibitor Pathway, Pharmacodynamics ⁶⁰	11.14	ITGB3 ITGA2B
12	Signaling events mediated by PTP1B ¹	11.1	ITGB3 ITGA2B
13	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	10.99	MPO ITGB3 ITGA2B GYPA
14	Arf6 signaling events ¹	10.9	ITGB3 ITGA2B
15	Hematopoietic Stem Cell Differentiation ¹	10.81	ITGB3 ITGA2B GYPA
16	Ephrin B reverse signaling ¹	10.75	ITGB3 ITGA2B
17	Signal transduction by L1 ⁶⁵	10.58	ITGB3 ITGA2B

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GO Terms for Malignant Gastric Germ Cell Tumor

Cellular components related to Malignant Gastric Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integrin complex	GO:0008305	8.96	ITGB3 ITGA2B
2	platelet alpha granule membrane	GO:0031092	8.62	ITGB3 ITGA2B

Biological processes related to Malignant Gastric Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	platelet degranulation	GO:0002576	9.32	ITGB3 ITGA2B
2	integrin-mediated signaling pathway	GO:0007229	9.26	ITGB3 ITGA2B
3	cell-matrix adhesion	GO:0007160	9.16	ITGB3 ITGA2B
4	viral entry into host cell	GO:0046718	8.96	ITGB3 GYPA
5	platelet aggregation	GO:0070527	8.62	ITGB3 ITGA2B

Molecular functions related to Malignant Gastric Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	virus receptor activity	GO:0001618	9.16	ITGB3 GYPA
2	extracellular matrix binding	GO:0050840	8.96	ITGB3 ITGA2B
3	fibrinogen binding	GO:0070051	8.62	ITGB3 ITGA2B

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