MCID: MLG067
MIFTS: 28

Malignant Giant Cell Tumor

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Malignant Giant Cell Tumor

MalaCards integrated aliases for Malignant Giant Cell Tumor:

Name: Malignant Giant Cell Tumor 12 15
Malignant Tumor, Giant Cell Type 12 70
Malignant Giant Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2705
NCIt 50 C4090
SNOMED-CT 67 83950009
UMLS 70 C0334229

Summaries for Malignant Giant Cell Tumor

MalaCards based summary : Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to bone giant cell sarcoma and malignant giant cell tumor of soft parts. An important gene associated with Malignant Giant Cell Tumor is H3-3A (H3.3 Histone A), and among its related pathways/superpathways are Shigellosis and Interferon Pathway. Affiliated tissues include bone, skin and uterus.

Related Diseases for Malignant Giant Cell Tumor

Diseases in the Benign Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 bone giant cell sarcoma 32.1 H3-3B H3-3A
2 malignant giant cell tumor of soft parts 31.8 S100B CD68 ACTC1
3 benign giant cell tumor 30.8 H3-3B H3-3A ACTC1
4 leiomyosarcoma 30.2 S100B ACTC1
5 fibrous histiocytoma 30.1 S100B CD68 ACTC1
6 malignant fibrous histiocytoma 30.1 S100B CD68 ACTC1
7 bone giant cell tumor 30.1 ZNF687 H3-3B H3-3A CD68
8 chondroblastoma 30.0 H3-3B H3-3A
9 bone osteosarcoma 29.9 H3-3B H3-3A
10 dermatofibrosarcoma protuberans 29.7 S100B ACTC1
11 malignant giant cell tumor of the tendon sheath 11.5
12 paget disease of bone 6 11.2
13 osteogenic sarcoma 10.4
14 plica syndrome 10.3
15 pigmented villonodular synovitis 10.3
16 synovitis 10.3
17 fibrosarcoma 10.3
18 villonodular synovitis 10.3
19 myopericytoma 10.1 S100B ACTC1
20 angiocentric glioma 10.1 S100B ACTC1
21 syringocystadenoma papilliferum 10.1 S100B ACTC1
22 adult brain stem glioma 10.1 H3-3B H3-3A
23 ossifying fibromyxoid tumor 10.1 S100B ACTC1
24 brain stem glioma 10.1 H3-3B H3-3A
25 polymorphous low-grade adenocarcinoma 10.1 S100B ACTC1
26 telangiectatic osteogenic sarcoma 10.1 H3-3B H3-3A
27 spinal cord astrocytoma 10.1 H3-3B H3-3A
28 adult oligodendroglioma 10.1 H3-3B H3-3A
29 childhood oligodendroglioma 10.1 H3-3B H3-3A
30 childhood brain stem glioma 10.1 H3-3B H3-3A
31 childhood pilocytic astrocytoma 10.1 H3-3B H3-3A
32 spiradenoma 10.1 S100B ACTC1
33 juvenile pilocytic astrocytoma 10.1 H3-3B H3-3A
34 clear cell chondrosarcoma 10.1 H3-3B H3-3A
35 adult astrocytic tumour 10.1 H3-3B H3-3A
36 chondrosarcoma 10.1
37 aneurysmal bone cysts 10.1
38 synovium neoplasm 10.1
39 mammary paget's disease 10.1
40 rare tumor 10.1
41 chondroblastic osteosarcoma 10.1 H3-3B H3-3A
42 colon leiomyoma 10.1 H3-3B H3-3A
43 pleomorphic liposarcoma 10.1 S100B ACTC1
44 perineurioma 10.1 S100B ACTC1
45 spinal cord glioma 10.1 H3-3B H3-3A
46 spinal cancer 10.1 H3-3B H3-3A
47 brain stem cancer 10.1 H3-3B H3-3A
48 hemangiopericytoma, malignant 10.1 S100B ACTC1
49 alpha thalassemia-x-linked intellectual disability syndrome 10.1 H3-3B H3-3A
50 myoepithelioma 10.1 S100B ACTC1

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to Malignant Giant Cell Tumor

Symptoms & Phenotypes for Malignant Giant Cell Tumor

Drugs & Therapeutics for Malignant Giant Cell Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Giant Cell Tumor

Genetic Tests for Malignant Giant Cell Tumor

Anatomical Context for Malignant Giant Cell Tumor

MalaCards organs/tissues related to Malignant Giant Cell Tumor:

40
Bone, Skin, Uterus, Kidney, Pancreas, Breast

Publications for Malignant Giant Cell Tumor

Articles related to Malignant Giant Cell Tumor:

(show top 50) (show all 150)
# Title Authors PMID Year
1
Malignant Giant Cell Tumor of Bone With a KRAS G12V Mutation. 61
33633024 2021
2
Prognostic Factors for Survival in Patients with Malignant Giant Cell Tumor of Bone: A Risk Nomogram Analysis Based on the Population. 61
33594036 2021
3
The Clinical Characteristics and Prediction Nomograms for Primary Spine Malignancies. 61
33732642 2021
4
Malignant giant cell tumor of bone or soft tissue treated by surgery with or without radiotherapy. 61
32293747 2020
5
Survival and prognosis in malignant giant cell tumor of bone: A population-based analysis from 1984 to 2013. 61
31667061 2019
6
Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone. 61
31285528 2019
7
Surgical resection and reconstructive techniques using autologous femoral head bone-grafting in treating partial acetabular defects arising from primary pelvic malignant tumors. 61
31627719 2019
8
Efficacy of a Modified Scoring System to Facilitate Surgical Decision-making for Diaphyseal Malignancies: When is Devitalized Tumor-bearing Autograft of Value? 61
31402605 2019
9
Chondroblastoma-like primary malignant giant cell tumor of the humerus - a case report. 61
30939886 2019
10
Malignancy in Giant Cell Tumor of Bone: A Review of the Literature. 61
30935298 2019
11
Malignant Giant Cell Tumor of Soft Tissue: A Case Report of Intramuscular Malignant Giant Cell Carcinoma of the Tensor Fasciae Latae. 61
31245324 2019
12
Secondary malignant giant cell tumor of bone with histone H3.3 mutation: A case series. 61
30522923 2018
13
[Malignant giant cell tumor of tendon sheath in finger: report of a case]. 61
29050082 2017
14
H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone. 61
28505000 2017
15
Overview of extremity musculoskeletal neoplasms at the Ahmadu Bello University Teaching Hospital Zaria, Nigeria. 61
28671156 2017
16
Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report. 61
26951080 2016
17
Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone. 61
26414220 2016
18
Incidence Trends in the Diagnosis of Giant Cell Tumor of Bone in Sweden Since 1958. 61
26537163 2015
19
Treatment and outcome of malignant giant cell tumor in the spine. 61
26040486 2015
20
Is total en bloc sacrectomy using a posterior-only approach feasible and safe for patients with malignant sacral tumors? 61
25815809 2015
21
Malignant giant cell tumor of the rib with lung metastasis in a man. 61
25276374 2014
22
[Allogeneic bone transplantation for pelvic reconstruction of large skeletal defects after tumor resection]. 61
24844014 2014
23
Triple-phase dynamic MRI: a new clue to predict malignant transformation of giant cell tumor of bone. 61
24239410 2014
24
Malignant giant cell tumor of the tendon sheath. 61
23981429 2013
25
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. 61
24436827 2013
26
[Clinical observation of surgical management for recurrent giant cell tumor of bone]. 61
23427489 2013
27
Secondary malignant giant cell tumor of the clivus: case report. 61
22277296 2012
28
Histological and clinical characteristics of malignant giant cell tumor of bone. 61
22350004 2012
29
[Analysis on recurrence factors associate with giant cell tumor of tendon sheath in upper extremity]. 61
22276505 2011
30
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. 61
21924561 2011
31
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. 61
21237496 2011
32
Malignant pigmented villonodular synovitis in the knee - report of a case with rapid clinical progression. 61
21270951 2011
33
Giant cell tumor of the distal femur associated with complete tumor necrosis. 61
20839701 2010
34
Primary malignant giant-cell tumor of bone has high survival rate. 61
19902306 2010
35
Malignant giant cell tumor in the posterior fossa of a neonate. 61
20192645 2010
36
[Soft tissue repairing and functional reconstruction in limb salvage operation on extremity bone malignant tumors]. 61
20360649 2010
37
Malignant giant cell tumor of the vulva. 61
19952930 2010
38
The epidemiology of malignant giant cell tumors of bone: an analysis of data from the Surveillance, Epidemiology and End Results Program (1975-2004). 61
21139931 2009
39
[Malignant giant cell tumor of the tendon sheaths in the hand]. 61
19094761 2008
40
[The analysis of the treatment of giant cell tumor of the pelvis and sacrum]. 61
18785558 2008
41
Fungating primary locally malignant giant cell tumor of ulna: a case report. 61
18552892 2008
42
Painful swollen leg--think beyond deep vein thrombosis or Baker's cyst. 61
18205917 2008
43
Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur. 61
18440162 2008
44
Disseminated malignant fibrous histiocytoma (giant cell rich): a case report. 61
18306558 2007
45
[Application of medial head gastrocnemius muscle flap to limb-salvage operation of proximal tibial malignant tumor]. 61
17546876 2007
46
[Endoscopic endonasal surgery for clival tumor]. 61
17432348 2007
47
Primary malignant giant cell tumor of bone: a series of three rare cases. 61
17592717 2007
48
Sarcomatoid basal cell carcinoma--predilection for osteosarcomatous differentiation: a series of 11 cases. 61
17001162 2006
49
Reliability of vascularized fibula in maintaining arthrodesis following extra-articular wide excisions of malignant musculoskeletal tumors. 61
16883453 2006
50
Metastasis of giant cell tumor to the breast: case report and review of the literature. 61
17036529 2006

Variations for Malignant Giant Cell Tumor

Expression for Malignant Giant Cell Tumor

Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for Malignant Giant Cell Tumor

Pathways related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.19 PFN1 H3-3B H3-3A
2 11.11 H3-3B H3-3A
3 10.47 H3-3B H3-3A

GO Terms for Malignant Giant Cell Tumor

Cellular components related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 8.96 H3-3B H3-3A
2 Barr body GO:0001740 8.62 H3-3B H3-3A

Biological processes related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 spermatid development GO:0007286 9.58 H3-3B H3-3A
2 positive regulation of cell growth GO:0030307 9.57 H3-3B H3-3A
3 single fertilization GO:0007338 9.56 H3-3B H3-3A
4 regulation of gene silencing by miRNA GO:0060964 9.55 H3-3B H3-3A
5 multicellular organism growth GO:0035264 9.54 H3-3B H3-3A
6 regulation of megakaryocyte differentiation GO:0045652 9.52 H3-3B H3-3A
7 negative regulation of gene expression, epigenetic GO:0045814 9.51 H3-3B H3-3A
8 oogenesis GO:0048477 9.49 H3-3B H3-3A
9 embryo implantation GO:0007566 9.48 H3-3B H3-3A
10 chromatin silencing at rDNA GO:0000183 9.46 H3-3B H3-3A
11 nucleus organization GO:0006997 9.43 H3-3B H3-3A
12 telomere organization GO:0032200 9.4 H3-3B H3-3A
13 DNA replication-independent nucleosome assembly GO:0006336 9.37 H3-3B H3-3A
14 muscle cell differentiation GO:0042692 9.32 H3-3B H3-3A
15 pericentric heterochromatin assembly GO:0031508 9.26 H3-3B H3-3A
16 regulation of centromere complex assembly GO:0090230 9.16 H3-3B H3-3A
17 negative regulation of chromosome condensation GO:1902340 8.96 H3-3B H3-3A
18 telomeric heterochromatin assembly GO:0031509 8.62 H3-3B H3-3A

Molecular functions related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosomal DNA binding GO:0031492 8.96 H3-3B H3-3A
2 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3-3B H3-3A

Sources for Malignant Giant Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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