MCID: MLG067
MIFTS: 27

Malignant Giant Cell Tumor

Categories: Bone diseases, Cancer diseases
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Aliases & Classifications for Malignant Giant Cell Tumor

MalaCards integrated aliases for Malignant Giant Cell Tumor:

Name: Malignant Giant Cell Tumor 11 14
Malignant Tumor, Giant Cell Type 11 71
Malignant Giant Cell Neoplasm 11

Classifications:



External Ids:

Disease Ontology 11 DOID:2705
NCIt 49 C4090
SNOMED-CT 68 83950009
UMLS 71 C0334229

Summaries for Malignant Giant Cell Tumor

MalaCards based summary: Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to malignant giant cell tumor of soft parts and bone giant cell sarcoma. An important gene associated with Malignant Giant Cell Tumor is H3-3B (H3.3 Histone B), and among its related pathways/superpathways are Effect of progerin on genes involved in Hutchinson-Gilford progeria syndrome and Tumor suppressor activity of SMARCB1. Affiliated tissues include bone, uterus and breast.

Related Diseases for Malignant Giant Cell Tumor

Diseases in the Benign Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor of soft parts 32.3 CD68 ACP5
2 bone giant cell sarcoma 31.9 TNFSF11 H3-3B H3-3A
3 pigmented villonodular synovitis 30.7 TNFSF11 CD68
4 benign giant cell tumor 30.2 TNFSF11 H3-3B H3-3A CD68
5 connective tissue benign neoplasm 30.1 TNFSF11 H3-3B H3-3A CD68
6 extraosseous osteosarcoma 30.0 SATB2 CD68
7 synovitis 30.0 TNFSF11 CD68 ACP5
8 mammary paget's disease 30.0 TNFSF11 ACP5
9 nodular tenosynovitis 30.0 CD68 ACP5
10 chondroblastoma 29.9 TNFSF11 H3-3B H3-3A
11 paget's disease of bone 29.6 ZNF687 TNFSF11 ACP5
12 bone giant cell tumor 29.6 ZNF687 TNFSF11 SATB2 H3-3B H3-3A CD68
13 bone osteosarcoma 29.5 TNFSF11 SATB2 H3-3B H3-3A
14 malignant giant cell tumor of the tendon sheath 11.5
15 paget disease of bone 6 11.3
16 osteogenic sarcoma 10.5
17 testicular germ cell tumor 10.4
18 cutaneous fibrous histiocytoma 10.4
19 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 10.4
20 malignant fibrous histiocytoma 10.4
21 tenosynovial giant cell tumor 10.4
22 fibrous histiocytoma 10.4
23 sarcoma 10.3
24 fibrosarcoma 10.3
25 villonodular synovitis 10.3
26 brain stem astrocytic neoplasm 10.2 H3-3B H3-3A
27 adult brain stem glioma 10.2 H3-3B H3-3A
28 brain stem glioma 10.2 H3-3B H3-3A
29 idh-wildtype anaplastic astrocytoma 10.2 H3-3B H3-3A
30 spinal cord astrocytoma 10.2 H3-3B H3-3A
31 adult oligodendroglioma 10.2 H3-3B H3-3A
32 childhood oligodendroglioma 10.2 H3-3B H3-3A
33 anaplastic pleomorphic xanthoastrocytoma 10.2 H3-3B H3-3A
34 pleomorphic xanthoastrocytoma 10.2 H3-3B H3-3A
35 astrocytoma, idh-mutant, grade 4 10.2 H3-3B H3-3A
36 juvenile pilocytic astrocytoma 10.2 H3-3B H3-3A
37 oculoectodermal syndrome 10.2 H3-3B H3-3A
38 fibrillary astrocytoma 10.2 H3-3B H3-3A
39 adult astrocytic tumor 10.2 H3-3B H3-3A
40 posterior fossa ependymoma 10.2 H3-3B H3-3A
41 childhood brain stem glioma 10.2 H3-3B H3-3A
42 clear cell chondrosarcoma 10.2 H3-3B H3-3A
43 spinal cord glioma 10.2 H3-3B H3-3A
44 intracranial structure hemangioma 10.2 H3-3B H3-3A
45 intracranial cavernous angioma 10.2 H3-3B H3-3A
46 idh-wildtype glioblastoma 10.2 H3-3B H3-3A
47 colon leiomyoma 10.2 H3-3B H3-3A
48 gliomatosis cerebri 10.2 H3-3B H3-3A
49 childhood astrocytic tumor 10.2 H3-3B H3-3A
50 supratentorial ependymoma 10.2 H3-3B H3-3A

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to Malignant Giant Cell Tumor

Symptoms & Phenotypes for Malignant Giant Cell Tumor

Drugs & Therapeutics for Malignant Giant Cell Tumor

Search Clinical Trials, NIH Clinical Center for Malignant Giant Cell Tumor

Genetic Tests for Malignant Giant Cell Tumor

Anatomical Context for Malignant Giant Cell Tumor

Organs/tissues related to Malignant Giant Cell Tumor:

MalaCards : Bone, Uterus, Breast, Skin, Pancreas, Kidney, Lung

Publications for Malignant Giant Cell Tumor

Articles related to Malignant Giant Cell Tumor:

(show top 50) (show all 162)
# Title Authors PMID Year
1
Metastatic Giant Cell Tumor Causing Small Bowel Intussusception on 18 F-FDG PET/CT. 62
35777978 2022
2
Malignant giant cell tumors of the tendon sheath of the right hip: A case report. 62
36312472 2022
3
Real-world treatment and survival outcome of malignant giant cell tumor of bone in the pre-denosumab versus post-denosumab era. 62
35562002 2022
4
Malignant giant cell tumor of toe: A case report and review of literature. 62
35665736 2022
5
Histological and immunohistochemical features and genetic alterations in the malignant progression of giant cell tumor of bone: a possible association with TP53 mutation and loss of H3K27 trimethylation. 62
34785767 2022
6
Multiple Focal Brown Tumors (Osteitis Fibrosa Cystica) in a Renal Transplant Recipient. 62
35295209 2022
7
Efficacy of Pazopanib in the Treatment of Metastatic Malignant Giant Cell Tumor of Soft Tissue: A Case Report. 62
35200563 2022
8
Malignant Giant Cell Tumor of Bone With a KRAS G12V Mutation. 62
33633024 2022
9
Reliability and Role of Mutation-specific H3F3A (Histone 3-3) G34W Immunohistochemistry to Differentiate Giant Cell Tumor of Bone From its Clinicoradiologic and Histologic Mimics: An Institutional Study. 62
34347625 2022
10
Reconstruction and repair, using mini-plate and bone graft for persons living with HIV with giant cell tumor of long bone: retrospective analysis of a single-center experience. 62
34727929 2021
11
Effect of Adjuvant Chemotherapy on Localized Malignant Giant Cell Tumor of Bone: A Systematic Review. 62
34771573 2021
12
Secondary malignant giant cell tumor of bone with histone H3.3 mutation: A case series. 62
30522923 2021
13
Malignant giant cell tumor in the left upper arm soft tissue of an adolescent: A case report. 62
34046473 2021
14
Prognostic Factors for Survival in Patients with Malignant Giant Cell Tumor of Bone: A Risk Nomogram Analysis Based on the Population. 62
33594036 2021
15
Primary malignant giant cell tumor of the sternum. 62
34249788 2021
16
The Clinical Characteristics and Prediction Nomograms for Primary Spine Malignancies. 62
33732642 2021
17
Malignant giant cell tumor of bone or soft tissue treated by surgery with or without radiotherapy. 62
32293747 2020
18
Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone. 62
31285528 2019
19
Survival and prognosis in malignant giant cell tumor of bone: A population-based analysis from 1984 to 2013. 62
31667061 2019
20
Surgical resection and reconstructive techniques using autologous femoral head bone-grafting in treating partial acetabular defects arising from primary pelvic malignant tumors. 62
31627719 2019
21
Efficacy of a Modified Scoring System to Facilitate Surgical Decision-making for Diaphyseal Malignancies: When is Devitalized Tumor-bearing Autograft of Value? 62
31402605 2019
22
Chondroblastoma-like primary malignant giant cell tumor of the humerus - a case report. 62
30939886 2019
23
Malignant Giant Cell Tumor of Soft Tissue: A Case Report of Intramuscular Malignant Giant Cell Carcinoma of the Tensor Fasciae Latae. 62
31245324 2019
24
Malignancy in Giant Cell Tumor of Bone: A Review of the Literature. 62
30935298 2019
25
[Malignant giant cell tumor of tendon sheath in finger: report of a case]. 62
29050082 2017
26
H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone. 62
28505000 2017
27
Overview of extremity musculoskeletal neoplasms at the Ahmadu Bello University Teaching Hospital Zaria, Nigeria. 62
28671156 2017
28
Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report. 62
26951080 2016
29
Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone. 62
26414220 2016
30
Incidence Trends in the Diagnosis of Giant Cell Tumor of Bone in Sweden Since 1958. 62
26537163 2015
31
Treatment and outcome of malignant giant cell tumor in the spine. 62
26040486 2015
32
Is total en bloc sacrectomy using a posterior-only approach feasible and safe for patients with malignant sacral tumors? 62
25815809 2015
33
Malignant giant cell tumor of the rib with lung metastasis in a man. 62
25276374 2014
34
[Allogeneic bone transplantation for pelvic reconstruction of large skeletal defects after tumor resection]. 62
24844014 2014
35
Triple-phase dynamic MRI: a new clue to predict malignant transformation of giant cell tumor of bone. 62
24239410 2014
36
Malignant giant cell tumor of the tendon sheath. 62
23981429 2013
37
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. 62
24436827 2013
38
[Clinical observation of surgical management for recurrent giant cell tumor of bone]. 62
23427489 2013
39
Secondary malignant giant cell tumor of the clivus: case report. 62
22277296 2012
40
Histological and clinical characteristics of malignant giant cell tumor of bone. 62
22350004 2012
41
[Analysis on recurrence factors associate with giant cell tumor of tendon sheath in upper extremity]. 62
22276505 2011
42
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. 62
21924561 2011
43
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. 62
21237496 2011
44
Malignant pigmented villonodular synovitis in the knee - report of a case with rapid clinical progression. 62
21270951 2011
45
Giant cell tumor of the distal femur associated with complete tumor necrosis. 62
20839701 2010
46
Primary malignant giant-cell tumor of bone has high survival rate. 62
19902306 2010
47
[Soft tissue repairing and functional reconstruction in limb salvage operation on extremity bone malignant tumors]. 62
20360649 2010
48
Malignant giant cell tumor in the posterior fossa of a neonate. 62
20192645 2010
49
Malignant giant cell tumor of the vulva. 62
19952930 2010
50
The epidemiology of malignant giant cell tumors of bone: an analysis of data from the Surveillance, Epidemiology and End Results Program (1975-2004). 62
21139931 2009

Variations for Malignant Giant Cell Tumor

Expression for Malignant Giant Cell Tumor

Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for Malignant Giant Cell Tumor

GO Terms for Malignant Giant Cell Tumor

Biological processes related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 telomere organization GO:0032200 9.26 H3-3B H3-3A
2 bone resorption GO:0045453 8.92 TNFSF11 ACP5

Molecular functions related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.92 H3-3A H3-3B

Sources for Malignant Giant Cell Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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