MCID: MLG067
MIFTS: 37

Malignant Giant Cell Tumor

Categories: Cancer diseases

Aliases & Classifications for Malignant Giant Cell Tumor

MalaCards integrated aliases for Malignant Giant Cell Tumor:

Name: Malignant Giant Cell Tumor 12 15
Malignant Tumor, Giant Cell Type 12 73
Malignant Giant Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2705
NCIt 50 C4090
SNOMED-CT 68 83950009
UMLS 73 C0334229

Summaries for Malignant Giant Cell Tumor

MalaCards based summary : Malignant Giant Cell Tumor, also known as malignant tumor, giant cell type, is related to malignant giant cell tumor of soft parts and bone giant cell sarcoma. An important gene associated with Malignant Giant Cell Tumor is H3F3A (H3 Histone Family Member 3A), and among its related pathways/superpathways are DNA Damage/Telomere Stress Induced Senescence and Transcriptional misregulation in cancer. The drugs Fentanyl and Pancreatic Polypeptide have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and uterus.

Related Diseases for Malignant Giant Cell Tumor

Diseases in the Giant Cell Tumor family:

Malignant Giant Cell Tumor

Diseases related to Malignant Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor of soft parts 33.2 ACP5 ACTC1 S100B
2 bone giant cell sarcoma 31.1 H3F3A H3F3B TP53
3 pigmented villonodular synovitis 29.9 ACP5 TP53
4 dermatofibrosarcoma protuberans 29.1 ACTC1 S100B TP53
5 leiomyosarcoma 29.1 ACTC1 S100B TP53
6 malignant giant cell tumor of the tendon sheath 12.3
7 paget disease of bone 6 11.1
8 giant cell tumor 10.6
9 myopericytoma 10.4 ACTC1 S100B
10 ossifying fibromyxoid tumor 10.4 ACTC1 S100B
11 syringocystadenoma papilliferum 10.4 ACTC1 S100B
12 angiocentric glioma 10.4 ACTC1 S100B
13 pleomorphic liposarcoma 10.4 ACTC1 S100B
14 cutaneous fibrous histiocytoma 10.4 ACTC1 S100B
15 bone giant cell tumor 10.3
16 spindle cell sarcoma 10.3 ACTC1 S100B
17 dendritic cell tumor 10.3 ACTC1 S100B
18 hemangiopericytoma, malignant 10.2 ACTC1 S100B
19 glioma susceptibility 1 10.2 H3F3A TP53
20 fibrillary astrocytoma 10.2 H3F3A TP53
21 chordoid glioma 10.2 S100B TP53
22 spiradenoma 10.2 S100B TP53
23 polymorphous low-grade adenocarcinoma 10.2 ACTC1 S100B
24 microglandular adenosis 10.2 S100B TP53
25 malignant fibroxanthoma 10.2 ACTC1 S100B
26 pleuropulmonary blastoma 10.2 S100B TP53
27 glycogen-rich clear cell breast carcinoma 10.1 ACTC1 TP53
28 papilloma of choroid plexus 10.1 S100B TP53
29 dedifferentiated liposarcoma 10.1 ACTC1 TP53
30 myoepithelioma 10.1 ACTC1 S100B
31 glomus tumor 10.1 ACTC1 TP53
32 embryonal sarcoma 10.1 S100B TP53
33 cerebral primitive neuroectodermal tumor 10.1 S100B TP53
34 fibrous histiocytoma 10.0 ACTC1 S100B
35 necrotizing sialometaplasia 10.0 ACTC1 TP53
36 hidradenocarcinoma 10.0 S100B TP53
37 adult astrocytic tumour 10.0 H3F3A H3F3B
38 granulosa cell tumor of the ovary 10.0 ACTC1 TP53
39 optic nerve glioma 10.0 S100B TP53
40 diffuse intrinsic pontine glioma 9.9 H3F3A H3F3B
41 cellular schwannoma 9.9 S100B TP53
42 synovitis 9.9
43 villonodular synovitis 9.9
44 chondroblastoma 9.9 H3F3A H3F3B
45 synovium cancer 9.8
46 ganglioglioma 9.8 H3F3A S100B TP53
47 atypical teratoid rhabdoid tumor 9.7 ACTC1 S100B TP53
48 inflammatory myofibroblastic tumor 9.7 ACTC1 S100B TP53
49 pleomorphic adenoma 9.7 ACTC1 S100B TP53
50 malignant peripheral nerve sheath tumor 9.7 ACTC1 S100B TP53

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor:



Diseases related to Malignant Giant Cell Tumor

Symptoms & Phenotypes for Malignant Giant Cell Tumor

Drugs & Therapeutics for Malignant Giant Cell Tumor

Drugs for Malignant Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
2 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
3 Liver Extracts Phase 3,Not Applicable
4 Adjuvants, Anesthesia Phase 3
5 Analgesics Phase 3
6 Analgesics, Opioid Phase 3
7 Anesthetics Phase 3
8 Anesthetics, General Phase 3
9 Anesthetics, Intravenous Phase 3
10 Central Nervous System Depressants Phase 3
11 Narcotics Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Cola Nutraceutical Phase 3,Not Applicable
14
nivolumab Approved Phase 2 946414-94-4
15 Antibodies Phase 2
16 Antibodies, Monoclonal Phase 2
17 Immunoglobulins Phase 2
18
Cyclophosphamide Approved, Investigational Not Applicable 50-18-0, 6055-19-2 2907
19 Alkylating Agents Not Applicable
20 Antineoplastic Agents, Alkylating Not Applicable
21 Antirheumatic Agents Not Applicable
22 Immunosuppressive Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
2 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
3 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Unknown status NCT00499733 Not Applicable cyclophosphamide

Search NIH Clinical Center for Malignant Giant Cell Tumor

Genetic Tests for Malignant Giant Cell Tumor

Anatomical Context for Malignant Giant Cell Tumor

MalaCards organs/tissues related to Malignant Giant Cell Tumor:

41
Bone, Liver, Uterus, Prostate, Lung, Kidney, Skin

Publications for Malignant Giant Cell Tumor

Articles related to Malignant Giant Cell Tumor:

(show top 50) (show all 63)
# Title Authors Year
1
H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone. ( 28505000 )
2017
2
Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report. ( 26951080 )
2016
3
Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone. ( 26414220 )
2015
4
Treatment and outcome of malignant giant cell tumor in the spine. ( 26040486 )
2015
5
Malignant giant cell tumor of the rib with lung metastasis in a man. ( 25276374 )
2014
6
Malignant giant cell tumor in the carpal tunnel: a case report and review of literature. ( 24436827 )
2013
7
Malignant giant cell tumor of the tendon sheath. ( 23981429 )
2013
8
Secondary malignant giant cell tumor of the clivus: case report. ( 22277296 )
2012
9
Histological and clinical characteristics of malignant giant cell tumor of bone. ( 22350004 )
2012
10
A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. ( 21237496 )
2011
11
A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. ( 21924561 )
2011
12
Primary malignant giant-cell tumor of bone has high survival rate. ( 19902306 )
2010
13
Malignant giant cell tumor of the vulva. ( 19952930 )
2010
14
Malignant giant cell tumor in the posterior fossa of a neonate. ( 20192645 )
2010
15
Fungating primary locally malignant giant cell tumor of ulna: a case report. ( 18552892 )
2008
16
Primary malignant giant cell tumor of bone: a series of three rare cases. ( 17592717 )
2007
17
Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. ( 16205965 )
2006
18
Malignant giant cell tumor of the tendon sheath. ( 14693023 )
2004
19
Primary de novo malignant giant cell tumor of kidney: a case report. ( 15207006 )
2004
20
Malignant giant cell tumor of soft parts. ( 14997349 )
2004
21
Malignant giant cell tumor of the sphenoid. ( 12715335 )
2003
22
Malignant giant cell tumor of soft parts in a mare. ( 14524631 )
2003
23
Malignant giant-cell tumor of the parietal bone: case report and review of the literature. ( 11220389 )
2001
24
Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). ( 11079016 )
2000
25
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. ( 10496598 )
1999
26
Malignant giant cell tumor of the tendon sheaths and joints (malignant pigmented villonodular synovitis). ( 9042281 )
1997
27
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. ( 8319177 )
1993
28
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. ( 8230758 )
1993
29
Significance of chromosomal abnormalities in a malignant giant cell tumor of bone. ( 1756489 )
1991
30
Malignant giant cell tumor associated with leiomyosarcoma of the uterus. ( 2317762 )
1990
31
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. ( 2175663 )
1990
32
Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: ultrastructural and immunohistochemical study and review of the literature. ( 2545593 )
1989
33
Primary malignant giant cell tumor of bone: "dedifferentiated" giant cell tumor. ( 2554283 )
1989
34
Malignant giant cell tumor of soft parts presenting as a skin tumor. ( 2658646 )
1989
35
Cytological characteristics of main cellular elements in benign and malignant giant cell tumor of bone. ( 3115731 )
1987
36
Secondary malignant giant-cell tumor of bone. Clinicopathological assessment of nineteen patients. ( 3745247 )
1986
37
Malignant giant cell tumor of tendon sheath. Report of a case. ( 2994359 )
1985
38
Malignant giant cell tumor of the frontal bone. ( 6585707 )
1984
39
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. ( 6465100 )
1984
40
Malignant giant cell tumor of bone: ultrastructural and immunohistologic evidence of histiocytic origin. ( 6490003 )
1984
41
Malignant giant-cell tumor of the distal end of the radius treated by a free vascularized fibular transplant. ( 7240328 )
1981
42
Primary malignant giant cell tumor of the mandible. Report of a case and review of the literature. ( 6937839 )
1981
43
Malignant giant cell tumor of soft tissues: a clinicopathologic, cytologic, ultrastructural, angiographic, and microangiographic study. ( 7226022 )
1981
44
Malignant giant cell tumor of the uterus. A clinico-pathologic, light- and electron-microscopic study of a case. ( 7270164 )
1981
45
A light and electron microscopic study of a case of radiation induced malignant giant cell tumor of the soft tissue. ( 379085 )
1979
46
Ultrastructural features of a malignant giant cell tumor of bone with areas of osteogenic sarcoma. ( 314048 )
1979
47
Primary malignant giant cell tumor of bone: a study of eight cases and review of the literature. ( 227563 )
1979
48
Malignant giant cell tumor of bone. Fine structure and localization of acid phosphatase. ( 212864 )
1978
49
The importance of recognizing malignant giant cell tumor of soft parts. ( 277073 )
1978
50
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. ( 195704 )
1977

Variations for Malignant Giant Cell Tumor

Expression for Malignant Giant Cell Tumor

Search GEO for disease gene expression data for Malignant Giant Cell Tumor.

Pathways for Malignant Giant Cell Tumor

GO Terms for Malignant Giant Cell Tumor

Cellular components related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome GO:0000228 9.16 H3F3A H3F3B
2 nuclear nucleosome GO:0000788 8.96 H3F3A H3F3B
3 Barr body GO:0001740 8.62 H3F3A H3F3B

Biological processes related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.62 H3F3A H3F3B S100B TP53
2 spermatid development GO:0007286 9.59 H3F3A H3F3B
3 multicellular organism growth GO:0035264 9.58 H3F3A H3F3B
4 regulation of gene silencing by miRNA GO:0060964 9.58 H3F3A H3F3B
5 positive regulation of cell growth GO:0030307 9.57 H3F3A H3F3B
6 single fertilization GO:0007338 9.56 H3F3A H3F3B
7 regulation of megakaryocyte differentiation GO:0045652 9.55 H3F3A H3F3B
8 positive regulation of gene expression, epigenetic GO:0045815 9.54 H3F3A H3F3B
9 negative regulation of gene expression, epigenetic GO:0045814 9.52 H3F3A H3F3B
10 embryo implantation GO:0007566 9.51 H3F3A H3F3B
11 chromatin silencing at rDNA GO:0000183 9.49 H3F3A H3F3B
12 oogenesis GO:0048477 9.48 H3F3A H3F3B
13 telomere organization GO:0032200 9.46 H3F3A H3F3B
14 nucleus organization GO:0006997 9.43 H3F3A H3F3B
15 DNA replication-independent nucleosome assembly GO:0006336 9.4 H3F3A H3F3B
16 muscle cell differentiation GO:0042692 9.37 H3F3A H3F3B
17 pericentric heterochromatin assembly GO:0031508 9.26 H3F3A H3F3B
18 regulation of centromere complex assembly GO:0090230 9.16 H3F3A H3F3B
19 telomeric heterochromatin assembly GO:0031509 8.96 H3F3A H3F3B
20 negative regulation of chromosome condensation GO:1902340 8.62 H3F3A H3F3B

Molecular functions related to Malignant Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.16 H3F3A H3F3B
2 nucleosomal DNA binding GO:0031492 8.96 H3F3A H3F3B
3 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3F3A H3F3B

Sources for Malignant Giant Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
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74 UMLS via Orphanet
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