MCID: MLG018
MIFTS: 25

Malignant Giant Cell Tumor of Soft Parts

Categories: Cancer diseases

Aliases & Classifications for Malignant Giant Cell Tumor of Soft Parts

MalaCards integrated aliases for Malignant Giant Cell Tumor of Soft Parts:

Name: Malignant Giant Cell Tumor of Soft Parts 12 15
Malignant Giant Cell Neoplasm of Soft Parts 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5638
NCIt 50 C8380
SNOMED-CT 67 48460009
UMLS 70 C0334554

Summaries for Malignant Giant Cell Tumor of Soft Parts

MalaCards based summary : Malignant Giant Cell Tumor of Soft Parts, also known as malignant giant cell neoplasm of soft parts, is related to malignant giant cell tumor and rare tumor. An important gene associated with Malignant Giant Cell Tumor of Soft Parts is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Wnt / Hedgehog / Notch. Related phenotype is hematopoietic system.

Related Diseases for Malignant Giant Cell Tumor of Soft Parts

Diseases related to Malignant Giant Cell Tumor of Soft Parts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor 31.5 S100B CD68 ACTC1
2 rare tumor 31.0 CR2 ACTC1
3 fibrous histiocytoma 30.7 S100B CD68 CD34 ACTC1
4 malignant fibrous histiocytoma 30.6 S100B PTPRC MB CD68 ACTC1
5 dermatofibrosarcoma protuberans 30.5 S100B CD34 ACTC1
6 benign giant cell tumor 10.5
7 myopericytoma 10.4 S100B ACTC1
8 angiocentric glioma 10.4 S100B ACTC1
9 bone giant cell tumor 10.4
10 light chain deposition disease 10.4 CD68 ACTC1
11 cobblestone retinal degeneration 10.4 PTPRC CD68
12 heart lymphoma 10.4 PTPRC CD68
13 syringocystadenoma papilliferum 10.4 S100B ACTC1
14 small intestinal sarcoma 10.4 PTPRC CD68
15 ossifying fibromyxoid tumor 10.3 S100B ACTC1
16 granulomatous gastritis 10.3 CR2 CD68
17 polymorphous low-grade adenocarcinoma 10.3 S100B ACTC1
18 t-cell/histiocyte rich large b cell lymphoma 10.3 CR2 CD68
19 cerebellopontine angle primitive neuroectodermal tumor 10.3 PTPRC CR2
20 non-langerhans-cell histiocytosis 10.3 CD68 ACTC1
21 langerhans cell sarcoma 10.3 CR2 CD68
22 glomangioma 10.3 CD34 ACTC1
23 esophageal tuberculosis 10.3 CR2 CD68
24 giant cell myocarditis 10.3 MB CD68
25 virus associated hemophagocytic syndrome 10.3 MB CD68
26 spiradenoma 10.3 S100B ACTC1
27 malignant triton tumor 10.3 S100B MB
28 glomangiomyoma 10.3 CD34 ACTC1
29 botryoid rhabdomyosarcoma 10.3 MB ACTC1
30 malignant granular cell myoblastoma 10.3 MB CD68
31 myoepithelioma 10.3 S100B PTPRC ACTC1
32 desmoplastic small round cell tumor 10.3 S100B PTPRC ACTC1
33 retroperitoneal hemangiopericytoma 10.3 CD68 CD34
34 rosai-dorfman disease 10.2 S100B CR2
35 multifocal osteogenic sarcoma 10.2 PTPRC CD34
36 villonodular synovitis 10.2 PTPRC CD68 ACP5
37 sarcomatoid squamous cell skin carcinoma 10.2 CD68 CD34
38 nodular tenosynovitis 10.2 PTPRC CD68 ACP5
39 skin sarcoma 10.2 CD68 CD34
40 langerhans cell histiocytosis 10.2 S100B PTPRC CD68
41 pigmented villonodular synovitis 10.2 PTPRC CD68 ACP5
42 pulmonary artery leiomyosarcoma 10.2 CD68 CD34
43 pleomorphic lipoma 10.2 CD68 CD34
44 kaposi sarcoma 10.2
45 osteogenic sarcoma 10.2
46 carcinosarcoma 10.2
47 intravascular fasciitis 10.2 CD68 CD34
48 angiolipoma 10.2 CD34 ACTC1
49 spindle cell lipoma 10.2 CD34 ACTC1
50 extraosseous osteosarcoma 10.2 CD68 CD34

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of Soft Parts:



Diseases related to Malignant Giant Cell Tumor of Soft Parts

Symptoms & Phenotypes for Malignant Giant Cell Tumor of Soft Parts

MGI Mouse Phenotypes related to Malignant Giant Cell Tumor of Soft Parts:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.32 ACTC1 CD34 CD68 CR2 ENG MB

Drugs & Therapeutics for Malignant Giant Cell Tumor of Soft Parts

Search Clinical Trials , NIH Clinical Center for Malignant Giant Cell Tumor of Soft Parts

Genetic Tests for Malignant Giant Cell Tumor of Soft Parts

Anatomical Context for Malignant Giant Cell Tumor of Soft Parts

Publications for Malignant Giant Cell Tumor of Soft Parts

Articles related to Malignant Giant Cell Tumor of Soft Parts:

(show all 16)
# Title Authors PMID Year
1
Disseminated malignant fibrous histiocytoma (giant cell rich): a case report. 61
18306558 2007
2
Malignant giant cell tumor of soft parts. 61
14997349 2004
3
Malignant giant cell tumor of soft parts in a mare. 61
14524631 2003
4
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. 61
10496598 1999
5
Atypical fibroxanthoma with osteoclast-like multinucleated giant cells. 61
9129703 1997
6
Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. 61
8319177 1993
7
Malignant giant cell tumor of soft parts presenting as a skin tumor. 61
2658646 1989
8
Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. 61
6465100 1984
9
Bronchogenic sarcomatoid squamous cell carcinoma with osteoclast-like giant cells. 61
6195080 1983
10
Mucinous ovarian tumors with giant cell mural nodules. A report of two cases. 61
6276116 1981
11
Ovarian mucinous tumors with sarcoma-like mural nodules: a report of seven cases. 61
498014 1979
12
The importance of recognizing malignant giant cell tumor of soft parts. 61
277073 1978
13
Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. 61
195704 1977
14
Primary prostatic malignant giant cell tumor of soft parts. 61
1067447 1976
15
Giant cell tumor of soft parts. A report of an equine and a feline case. 61
1229057 1975
16
Malignant giant cell tumor of soft parts. An analysis of 32 cases. 61
5031245 1972

Variations for Malignant Giant Cell Tumor of Soft Parts

Expression for Malignant Giant Cell Tumor of Soft Parts

Search GEO for disease gene expression data for Malignant Giant Cell Tumor of Soft Parts.

Pathways for Malignant Giant Cell Tumor of Soft Parts

GO Terms for Malignant Giant Cell Tumor of Soft Parts

Cellular components related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.76 WNT5A THY1 PTPRC NT5E MB FABP4
2 focal adhesion GO:0005925 9.56 THY1 PTPRC ENG ACTC1
3 external side of plasma membrane GO:0009897 9.35 THY1 PTPRC NT5E ENG CD34
4 cell surface GO:0009986 9.1 WNT5A THY1 PTPRC NT5E ENG CD34

Biological processes related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.65 WNT5A POU5F1 ENG CD34 ACTC1
2 negative regulation of protein kinase activity GO:0006469 9.58 THY1 PTPRC FABP4
3 positive regulation of ossification GO:0045778 9.46 WNT5A WNT10B
4 negative regulation of protein tyrosine kinase activity GO:0061099 9.43 THY1 PTPRC
5 positive regulation of stem cell proliferation GO:2000648 9.37 PTPRC NANOG
6 negative regulation of protein autophosphorylation GO:0031953 9.32 PTPRC ENG
7 endodermal cell fate specification GO:0001714 9.16 POU5F1 NANOG
8 positive regulation of timing of anagen GO:0051885 8.96 WNT5A WNT10B
9 hematopoietic stem cell proliferation GO:0071425 8.8 WNT5A WNT10B CD34

Sources for Malignant Giant Cell Tumor of Soft Parts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....