Malignant Giant Cell Tumor of Soft Parts disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Malignant Giant Cell Tumor of Soft Parts

MalaCards integrated aliases for Malignant Giant Cell Tumor of Soft Parts:

Name: Malignant Giant Cell Tumor of Soft Parts ¹² ¹⁵

Malignant Giant Cell Neoplasm of Soft Parts ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5638

NCIt ⁵⁰ C8380

SNOMED-CT ⁶⁷ 48460009

UMLS ⁷⁰ C0334554

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Summaries for Malignant Giant Cell Tumor of Soft Parts

MalaCards based summary : Malignant Giant Cell Tumor of Soft Parts, also known as malignant giant cell neoplasm of soft parts, is related to malignant giant cell tumor and rare tumor. An important gene associated with Malignant Giant Cell Tumor of Soft Parts is ACTC1 (Actin Alpha Cardiac Muscle 1), and among its related pathways/superpathways are Human Embryonic Stem Cell Pluripotency and Wnt / Hedgehog / Notch. Related phenotype is hematopoietic system.

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Related Diseases for Malignant Giant Cell Tumor of Soft Parts

Diseases related to Malignant Giant Cell Tumor of Soft Parts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)

#	Related Disease	Score	Top Affiliating Genes
1	malignant giant cell tumor	31.5	S100B CD68 ACTC1
2	rare tumor	31.0	CR2 ACTC1
3	fibrous histiocytoma	30.7	S100B CD68 CD34 ACTC1
4	malignant fibrous histiocytoma	30.6	S100B PTPRC MB CD68 ACTC1
5	dermatofibrosarcoma protuberans	30.5	S100B CD34 ACTC1
6	benign giant cell tumor	10.5
7	myopericytoma	10.4	S100B ACTC1
8	angiocentric glioma	10.4	S100B ACTC1
9	bone giant cell tumor	10.4
10	light chain deposition disease	10.4	CD68 ACTC1
11	cobblestone retinal degeneration	10.4	PTPRC CD68
12	heart lymphoma	10.4	PTPRC CD68
13	syringocystadenoma papilliferum	10.4	S100B ACTC1
14	small intestinal sarcoma	10.4	PTPRC CD68
15	ossifying fibromyxoid tumor	10.3	S100B ACTC1
16	granulomatous gastritis	10.3	CR2 CD68
17	polymorphous low-grade adenocarcinoma	10.3	S100B ACTC1
18	t-cell/histiocyte rich large b cell lymphoma	10.3	CR2 CD68
19	cerebellopontine angle primitive neuroectodermal tumor	10.3	PTPRC CR2
20	non-langerhans-cell histiocytosis	10.3	CD68 ACTC1
21	langerhans cell sarcoma	10.3	CR2 CD68
22	glomangioma	10.3	CD34 ACTC1
23	esophageal tuberculosis	10.3	CR2 CD68
24	giant cell myocarditis	10.3	MB CD68
25	virus associated hemophagocytic syndrome	10.3	MB CD68
26	spiradenoma	10.3	S100B ACTC1
27	malignant triton tumor	10.3	S100B MB
28	glomangiomyoma	10.3	CD34 ACTC1
29	botryoid rhabdomyosarcoma	10.3	MB ACTC1
30	malignant granular cell myoblastoma	10.3	MB CD68
31	myoepithelioma	10.3	S100B PTPRC ACTC1
32	desmoplastic small round cell tumor	10.3	S100B PTPRC ACTC1
33	retroperitoneal hemangiopericytoma	10.3	CD68 CD34
34	rosai-dorfman disease	10.2	S100B CR2
35	multifocal osteogenic sarcoma	10.2	PTPRC CD34
36	villonodular synovitis	10.2	PTPRC CD68 ACP5
37	sarcomatoid squamous cell skin carcinoma	10.2	CD68 CD34
38	nodular tenosynovitis	10.2	PTPRC CD68 ACP5
39	skin sarcoma	10.2	CD68 CD34
40	langerhans cell histiocytosis	10.2	S100B PTPRC CD68
41	pigmented villonodular synovitis	10.2	PTPRC CD68 ACP5
42	pulmonary artery leiomyosarcoma	10.2	CD68 CD34
43	pleomorphic lipoma	10.2	CD68 CD34
44	kaposi sarcoma	10.2
45	osteogenic sarcoma	10.2
46	carcinosarcoma	10.2
47	intravascular fasciitis	10.2	CD68 CD34
48	angiolipoma	10.2	CD34 ACTC1
49	spindle cell lipoma	10.2	CD34 ACTC1
50	extraosseous osteosarcoma	10.2	CD68 CD34

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of Soft Parts:

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Symptoms & Phenotypes for Malignant Giant Cell Tumor of Soft Parts

MGI Mouse Phenotypes related to Malignant Giant Cell Tumor of Soft Parts:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system	MP:0005397	9.32	ACTC1 CD34 CD68 CR2 ENG MB

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Drugs & Therapeutics for Malignant Giant Cell Tumor of Soft Parts

Search Clinical Trials , NIH Clinical Center for Malignant Giant Cell Tumor of Soft Parts

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Genetic Tests for Malignant Giant Cell Tumor of Soft Parts

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Anatomical Context for Malignant Giant Cell Tumor of Soft Parts

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Publications for Malignant Giant Cell Tumor of Soft Parts

Articles related to Malignant Giant Cell Tumor of Soft Parts:

(show all 16)

#	Title	Authors	PMID	Year
1	Disseminated malignant fibrous histiocytoma (giant cell rich): a case report. ⁶¹	Rao S...Prathiba D	18306558	2007
2	Malignant giant cell tumor of soft parts. ⁶¹	Dodd LG...Brigman B	14997349	2004
3	Malignant giant cell tumor of soft parts in a mare. ⁶¹	Marryatt PA	14524631	2003
4	Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. ⁶¹	Folpe AL...Weiss SW	10496598	1999
5	Atypical fibroxanthoma with osteoclast-like multinucleated giant cells. ⁶¹	Khan ZM...Cockerell CJ	9129703	1997
6	Metastatic dermatofibrosarcoma protuberans with fibrosarcomatous change in the absence of local recurrence. A case report of simultaneous occurrence with a malignant giant cell tumor of soft parts. ⁶¹	Eisen RN...Tallini G	8319177	1993
7	Malignant giant cell tumor of soft parts presenting as a skin tumor. ⁶¹	Gould E...Menendez-Aponte S	2658646	1989
8	Sarcomatoid carcinoma (so-called pseudosarcoma) of the larynx simulating malignant giant cell tumor of soft parts. A case report. ⁶¹	Alguacil-Garcia A...Pettigrew NM	6465100	1984
9	Bronchogenic sarcomatoid squamous cell carcinoma with osteoclast-like giant cells. ⁶¹	Love GL...Daroca PJ	6195080	1983
10	Mucinous ovarian tumors with giant cell mural nodules. A report of two cases. ⁶¹	Russell P...Bannatyne PM	6276116	1981
11	Ovarian mucinous tumors with sarcoma-like mural nodules: a report of seven cases. ⁶¹	Prat J...Scully RE	498014	1979
12	The importance of recognizing malignant giant cell tumor of soft parts. ⁶¹	Robins RE...Fris RJ	277073	1978
13	Malignant giant cell tumor of soft parts. An ultrastructural study of four cases. ⁶¹	Alguacil-Garcia A...Goellner JR	195704	1977
14	Primary prostatic malignant giant cell tumor of soft parts. ⁶¹	Ramirez G...Kim JT	1067447	1976
15	Giant cell tumor of soft parts. A report of an equine and a feline case. ⁶¹	Ford GH...Brown PH	1229057	1975
16	Malignant giant cell tumor of soft parts. An analysis of 32 cases. ⁶¹	Guccion JG...Enzinger FM	5031245	1972

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Genes for Malignant Giant Cell Tumor of Soft Parts

Genes related to Malignant Giant Cell Tumor of Soft Parts (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	7.38	GeneCards inferred via : Publications (show sections)
2	S100B	S100 Calcium Binding Protein B	Protein Coding	7.38	GeneCards inferred via : Publications (show sections)
3	CD68	CD68 Molecule	Protein Coding	5.39	DISEASES inferred ¹⁵
4	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	5.09	DISEASES inferred ¹⁵
5	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	4.46	DISEASES inferred ¹⁵
6	WNT10B	Wnt Family Member 10B	Protein Coding	4.21	DISEASES inferred ¹⁵
7	FABP4	Fatty Acid Binding Protein 4	Protein Coding	3.86	DISEASES inferred ¹⁵
8	CR2	Complement C3d Receptor 2	Protein Coding	3.83	DISEASES inferred ¹⁵
9	WNT5A	Wnt Family Member 5A	Protein Coding	3.69	DISEASES inferred ¹⁵
10	NT5E	5'-Nucleotidase Ecto	Protein Coding	3.65	DISEASES inferred ¹⁵
11	MB	Myoglobin	Protein Coding	3.61	DISEASES inferred ¹⁵
12	CD34	CD34 Molecule	Protein Coding	3.5	DISEASES inferred ¹⁵
13	ENG	Endoglin	Protein Coding	3.44	DISEASES inferred ¹⁵
14	THY1	Thy-1 Cell Surface Antigen	Protein Coding	3.41	DISEASES inferred ¹⁵
15	NANOG	Nanog Homeobox	Protein Coding	3.33	DISEASES inferred ¹⁵
16	POU5F1	POU Class 5 Homeobox 1	Protein Coding	3.27	DISEASES inferred ¹⁵

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Variations for Malignant Giant Cell Tumor of Soft Parts

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Expression for Malignant Giant Cell Tumor of Soft Parts

Search GEO for disease gene expression data for Malignant Giant Cell Tumor of Soft Parts.

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Pathways for Malignant Giant Cell Tumor of Soft Parts

Pathways related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	Human Embryonic Stem Cell Pluripotency ⁶³ Show member pathways Factors Promoting Cardiogenesis in Vertebrates ⁶³	12.22	WNT5A WNT10B POU5F1 NANOG
2	Wnt / Hedgehog / Notch ⁴	11.93	WNT5A POU5F1 NANOG ENG
3	Wnt Signaling Pathway and Pluripotency ¹ Show member pathways Wnt Signaling Pathway ¹	11.87	WNT5A WNT10B POU5F1 NANOG
4	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.81	WNT5A POU5F1 NANOG
5	Signaling pathways regulating pluripotency of stem cells ³⁶	11.71	WNT5A WNT10B POU5F1 NANOG
6	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.51	THY1 PTPRC CD34
7	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.45	THY1 PTPRC CD34
8	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.42	THY1 PTPRC ENG CD68 CD34
9	Cardiac Progenitor Differentiation ¹	11.18	THY1 POU5F1 NANOG ACTC1
10	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.08	WNT10B THY1 PTPRC FABP4 ENG CD34
11	Oct4 in Mammalian ESC Pluripotency ⁶³	10.73	POU5F1 NANOG
12	Human Early Embryo Development ⁶³ Show member pathways POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation ⁶⁵	10.46	POU5F1 NANOG

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GO Terms for Malignant Giant Cell Tumor of Soft Parts

Cellular components related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.76	WNT5A THY1 PTPRC NT5E MB FABP4
2	focal adhesion	GO:0005925	9.56	THY1 PTPRC ENG ACTC1
3	external side of plasma membrane	GO:0009897	9.35	THY1 PTPRC NT5E ENG CD34
4	cell surface	GO:0009986	9.1	WNT5A THY1 PTPRC NT5E ENG CD34

Biological processes related to Malignant Giant Cell Tumor of Soft Parts according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.65	WNT5A POU5F1 ENG CD34 ACTC1
2	negative regulation of protein kinase activity	GO:0006469	9.58	THY1 PTPRC FABP4
3	positive regulation of ossification	GO:0045778	9.46	WNT5A WNT10B
4	negative regulation of protein tyrosine kinase activity	GO:0061099	9.43	THY1 PTPRC
5	positive regulation of stem cell proliferation	GO:2000648	9.37	PTPRC NANOG
6	negative regulation of protein autophosphorylation	GO:0031953	9.32	PTPRC ENG
7	endodermal cell fate specification	GO:0001714	9.16	POU5F1 NANOG
8	positive regulation of timing of anagen	GO:0051885	8.96	WNT5A WNT10B
9	hematopoietic stem cell proliferation	GO:0071425	8.8	WNT5A WNT10B CD34

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