MCID: MLG019
MIFTS: 29

Malignant Giant Cell Tumor of the Tendon Sheath

Categories: Cancer diseases, Muscle diseases

Aliases & Classifications for Malignant Giant Cell Tumor of the Tendon Sheath

MalaCards integrated aliases for Malignant Giant Cell Tumor of the Tendon Sheath:

Name: Malignant Giant Cell Tumor of the Tendon Sheath 12 15
Malignant Giant Cell Neoplasm of the Tendon Sheath 12
Giant Cell Tumour of Tendon Sheath, Malignant 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2704
NCIt 49 C6535
SNOMED-CT 67 128778009
UMLS 71 C1266168

Summaries for Malignant Giant Cell Tumor of the Tendon Sheath

MalaCards based summary : Malignant Giant Cell Tumor of the Tendon Sheath, also known as malignant giant cell neoplasm of the tendon sheath, is related to villonodular synovitis and pigmented villonodular synovitis. An important gene associated with Malignant Giant Cell Tumor of the Tendon Sheath is CAND2 (Cullin Associated And Neddylation Dissociated 2 (Putative)), and among its related pathways/superpathways are PEDF Induced Signaling and ERK Signaling. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Malignant Giant Cell Tumor of the Tendon Sheath

Diseases related to Malignant Giant Cell Tumor of the Tendon Sheath via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 villonodular synovitis 30.0 CSF1 CD68
2 pigmented villonodular synovitis 29.0 PTPRC CSF1R CSF1 CD68
3 benign giant cell tumor 29.0 PTPRC CSF1R CSF1 CD68
4 malignant giant cell tumor 10.6
5 plica syndrome 10.2
6 nodular tenosynovitis 10.2
7 synovitis 10.2
8 peritonitis 10.2
9 tenosynovitis 10.2
10 kidney benign neoplasm 10.1 ROS1 NTRK3
11 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.1 CSF1R CSF1
12 occipital lobe neoplasm 10.1 ROS1 ALK
13 nodular ganglioneuroblastoma 10.0 NTRK2 ALK
14 congenital mesoblastic nephroma 10.0 NTRK3 NTRK2 NTRK1
15 conjunctival pigmentation 9.9 SOX10 CD68
16 ganglioneuroma 9.9 NTRK3 NTRK2 NTRK1
17 lung non-squamous non-small cell carcinoma 9.9 ROS1 ALK
18 breast lipoma 9.9 PTPRC ALK
19 primary cutaneous anaplastic large cell lymphoma 9.9 PTPRC ALK
20 bone lymphoma 9.9 PTPRC ALK
21 ocular cicatricial pemphigoid 9.9 NTRK1 CSF1
22 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 9.9 CSF1R CSF1 CD33
23 large cell neuroendocrine carcinoma 9.9 NTRK3 NTRK2 ALK
24 central hypoventilation syndrome, congenital 9.8 SOX10 NTRK2 ALK
25 malignant spindle cell melanoma 9.8 SOX10 CD68
26 multicentric reticulohistiocytosis 9.8 CSF1 CD68
27 cobblestone retinal degeneration 9.8 PTPRC CD68
28 glomeruloid hemangioma 9.7 PTPRC CD68
29 differentiated thyroid carcinoma 9.7 NTRK3 NTRK1 ALK
30 histiocytic and dendritic cell cancer 9.7 PTPRC CD68
31 oligodendroglioma 9.7 SOX10 NTRK3 NTRK2 NTRK1
32 autonomic nervous system benign neoplasm 9.7 NTRK2 NTRK1 ALK
33 peripheral nervous system benign neoplasm 9.7 NTRK2 NTRK1 ALK
34 sarcomatoid transitional cell carcinoma 9.7 CD68 ALK
35 omenn syndrome 9.7 PTPRC CSF1R CSF1
36 ganglioneuroblastoma 9.7 NTRK2 NTRK1 ALK
37 malignant giant cell tumor of soft parts 9.7 PTPRC CD68
38 adenoid cystic carcinoma 9.7 SOX10 NTRK3 NTRK2 NTRK1
39 dendritic cell tumor 9.7 PTPRC CD68
40 conventional fibrosarcoma 9.6 PTPRC CD68
41 intravascular fasciitis 9.6 CD68 ALK
42 chronic myelomonocytic leukemia 9.6 ROS1 CSF1R CSF1 CD33
43 anaplastic large cell lymphoma 9.6 PTPRC CSF1R ALK
44 autonomic nervous system neoplasm 9.6 NTRK2 NTRK1 ALK
45 peripheral nervous system neoplasm 9.6 NTRK2 NTRK1 ALK
46 myeloid sarcoma 9.5 PTPRC CD68 CD33
47 spitzoid melanoma 9.5 ROS1 NTRK3 NTRK1 ALK
48 fibrosarcoma 9.5 NTRK3 NTRK1 CSF1R ALK
49 langerhans cell histiocytosis 9.4 PTPRC CSF1 CD68
50 sarcoma 9.4 ROS1 PTPRC CSF1R ALK

Graphical network of the top 20 diseases related to Malignant Giant Cell Tumor of the Tendon Sheath:



Diseases related to Malignant Giant Cell Tumor of the Tendon Sheath

Symptoms & Phenotypes for Malignant Giant Cell Tumor of the Tendon Sheath

GenomeRNAi Phenotypes related to Malignant Giant Cell Tumor of the Tendon Sheath according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-3 9.74 CSF1R
2 Decreased viability GR00221-A-1 9.74 ALK CSF1R NTRK2 ROS1
3 Decreased viability GR00221-A-2 9.74 NTRK2 ROS1 NTRK3
4 Decreased viability GR00221-A-4 9.74 ALK CSF1R NTRK2 NTRK3
5 Decreased viability GR00249-S 9.74 ALK ROS1
6 Decreased viability GR00342-S-1 9.74 ROS1
7 Decreased viability GR00402-S-2 9.74 CSF1R
8 Decreased cell viability after pRB stimulation GR00230-A-1 9.26 NTRK1 NTRK2
9 Decreased substrate adherent cell growth GR00193-A-1 9.26 ROS1
10 Decreased substrate adherent cell growth GR00193-A-2 9.26 ALK CSF1R ROS1
11 Decreased simian virus 40 (SV40) infection GR00356-A-2 8.85 CSF1R

MGI Mouse Phenotypes related to Malignant Giant Cell Tumor of the Tendon Sheath:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.02 ALK CAND2 COL6A3 CSF1 CSF1R NTRK1
2 no phenotypic analysis MP:0003012 9.76 CD68 CSF1 CSF1R NTRK1 NTRK3 PTPRC
3 hearing/vestibular/ear MP:0005377 9.65 CSF1 CSF1R NTRK1 NTRK2 NTRK3
4 respiratory system MP:0005388 9.43 ALK CSF1 NTRK2 NTRK3 PTPRC SOX10
5 skeleton MP:0005390 9.23 ALK CAND2 CD68 COL6A3 CSF1 CSF1R

Drugs & Therapeutics for Malignant Giant Cell Tumor of the Tendon Sheath

Search Clinical Trials , NIH Clinical Center for Malignant Giant Cell Tumor of the Tendon Sheath

Genetic Tests for Malignant Giant Cell Tumor of the Tendon Sheath

Anatomical Context for Malignant Giant Cell Tumor of the Tendon Sheath

Publications for Malignant Giant Cell Tumor of the Tendon Sheath

Articles related to Malignant Giant Cell Tumor of the Tendon Sheath:

# Title Authors PMID Year
1
Malignant giant cell tumor of the tendon sheath. 61
23981429 2013
2
Malignant giant cell tumor of the tendon sheath. 61
14693023 2004
3
Malignant giant cell tumor of the tendon sheath: an autopsy report and review of the literature. 61
8230758 1993
4
[Is the malignant giant cell tumor of soft tissues, with regard to its origin, identical with the malignant giant cell tumor of the tendon sheath? Description of a case and overview of the literature]. 61
7022289 1981
5
Malignant giant cell tumor of the tendon sheath. Ultrastructural study and review of the literature. 61
4346849 1973

Variations for Malignant Giant Cell Tumor of the Tendon Sheath

Expression for Malignant Giant Cell Tumor of the Tendon Sheath

Search GEO for disease gene expression data for Malignant Giant Cell Tumor of the Tendon Sheath.

Pathways for Malignant Giant Cell Tumor of the Tendon Sheath

Pathways related to Malignant Giant Cell Tumor of the Tendon Sheath according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 ROS1 NTRK3 NTRK2 NTRK1 CSF1R CSF1
2
Show member pathways
13.45 SOX10 ROS1 NTRK3 NTRK2 NTRK1 CSF1R
3
Show member pathways
13.35 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
4
Show member pathways
13.32 ROS1 PTPRC NTRK3 NTRK2 NTRK1 CSF1R
5
Show member pathways
13.12 ROS1 NTRK3 NTRK2 NTRK1 CSF1R CSF1
6
Show member pathways
13.11 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
7
Show member pathways
13.08 PTPRC NTRK3 NTRK2 NTRK1 CSF1R CSF1
8
Show member pathways
13.04 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
9
Show member pathways
12.87 NTRK3 NTRK2 NTRK1 CSF1R ALK
10
Show member pathways
12.79 NTRK2 NTRK1 CSF1R CSF1 COL6A3
11 12.6 NTRK2 NTRK1 CSF1R CSF1
12
Show member pathways
12.57 NTRK2 NTRK1 CSF1R CSF1
13
Show member pathways
12.57 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
14
Show member pathways
12.07 NTRK3 NTRK2 NTRK1 CSF1R
15 11.95 NTRK3 NTRK2 NTRK1
16
Show member pathways
11.93 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
17 11.84 NTRK3 NTRK2 NTRK1
18 11.75 CSF1R CSF1 CD33
19 11.73 PTPRC CSF1 CD68 CD33
20 11.54 PTPRC CSF1R CSF1
21 11.52 ROS1 NTRK2 NTRK1 CSF1R ALK
22
Show member pathways
11.44 NTRK3 NTRK2 NTRK1
23 11.31 CSF1R CSF1 ALK
24 11.23 NTRK3 NTRK2 NTRK1
25 10.81 CSF1 CD68
26
Show member pathways
10.61 NTRK2 NTRK1
27 10.13 ROS1 NTRK3 NTRK2 NTRK1 CSF1R CSF1

GO Terms for Malignant Giant Cell Tumor of the Tendon Sheath

Cellular components related to Malignant Giant Cell Tumor of the Tendon Sheath according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 10.02 ROS1 PTPRC NTRK3 NTRK2 NTRK1 CSF1R
2 plasma membrane GO:0005886 9.96 ROS1 PTPRC NTRK3 NTRK2 NTRK1 CSF1R
3 integral component of plasma membrane GO:0005887 9.56 ROS1 PTPRC NTRK3 NTRK2 NTRK1 CSF1R
4 CSF1-CSF1R complex GO:1990682 9.16 CSF1R CSF1
5 receptor complex GO:0043235 9.1 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK

Biological processes related to Malignant Giant Cell Tumor of the Tendon Sheath according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.08 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
2 cell differentiation GO:0030154 10.04 SOX10 ROS1 NTRK3 NTRK2 NTRK1
3 phosphorylation GO:0016310 9.97 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
4 positive regulation of cell proliferation GO:0008284 9.96 NTRK3 NTRK2 CSF1R CSF1
5 nervous system development GO:0007399 9.95 NTRK3 NTRK2 NTRK1 ALK
6 positive regulation of gene expression GO:0010628 9.94 SOX10 NTRK3 NTRK2 CSF1
7 protein phosphorylation GO:0006468 9.91 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
8 positive regulation of protein phosphorylation GO:0001934 9.86 NTRK3 NTRK2 NTRK1 CSF1R
9 protein autophosphorylation GO:0046777 9.84 NTRK2 NTRK1 CSF1R ALK
10 positive regulation of neuron projection development GO:0010976 9.79 NTRK3 NTRK2 NTRK1
11 activation of MAPK activity GO:0000187 9.79 PTPRC NTRK3 ALK
12 circadian rhythm GO:0007623 9.78 NTRK3 NTRK2 NTRK1
13 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.77 NTRK3 NTRK2 NTRK1
14 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.77 PTPRC NTRK3 NTRK2 NTRK1 CSF1R
15 positive regulation of MAPK cascade GO:0043410 9.76 PTPRC NTRK3 NTRK2 NTRK1
16 positive regulation of synapse assembly GO:0051965 9.74 NTRK3 NTRK2 NTRK1
17 cellular response to nerve growth factor stimulus GO:1990090 9.69 NTRK3 NTRK2 NTRK1
18 oligodendrocyte differentiation GO:0048709 9.67 SOX10 NTRK2
19 response to axon injury GO:0048678 9.67 NTRK3 NTRK1
20 osteoclast differentiation GO:0030316 9.66 CSF1R CSF1
21 positive regulation of Ras protein signal transduction GO:0046579 9.65 NTRK1 CSF1
22 regulation of MAPK cascade GO:0043408 9.65 NTRK3 NTRK2 NTRK1
23 macrophage differentiation GO:0030225 9.64 CSF1R CSF1
24 neurotrophin TRK receptor signaling pathway GO:0048011 9.63 NTRK2 NTRK1
25 myelination in peripheral nervous system GO:0022011 9.63 NTRK3 NTRK2
26 peptidyl-tyrosine phosphorylation GO:0018108 9.63 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
27 positive regulation of macrophage chemotaxis GO:0010759 9.62 CSF1R CSF1
28 neuronal action potential propagation GO:0019227 9.58 NTRK3 NTRK2
29 microglial cell proliferation GO:0061518 9.58 CSF1R CSF1
30 regulation of protein kinase B signaling GO:0051896 9.58 NTRK3 NTRK2 NTRK1
31 macrophage colony-stimulating factor signaling pathway GO:0038145 9.55 CSF1R CSF1
32 positive regulation of protein tyrosine phosphatase activity GO:1903615 9.52 PTPRC CD33
33 mechanoreceptor differentiation GO:0042490 9.5 NTRK3 NTRK2 NTRK1
34 neurotrophin signaling pathway GO:0038179 9.43 NTRK3 NTRK2 NTRK1
35 positive regulation of kinase activity GO:0033674 9.43 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
36 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.17 ROS1 NTRK3 NTRK2 NTRK1 CSF1R CSF1

Molecular functions related to Malignant Giant Cell Tumor of the Tendon Sheath according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 9.97 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
2 nucleotide binding GO:0000166 9.95 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
3 ATP binding GO:0005524 9.93 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
4 kinase activity GO:0016301 9.85 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
5 protein kinase activity GO:0004672 9.8 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
6 protein phosphatase binding GO:0019903 9.61 ROS1 CSF1R CD33
7 neurotrophin binding GO:0043121 9.43 NTRK3 NTRK2 NTRK1
8 protein tyrosine kinase activity GO:0004713 9.43 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK
9 GPI-linked ephrin receptor activity GO:0005004 9.4 NTRK3 NTRK1
10 neurotrophin receptor activity GO:0005030 9.33 NTRK3 NTRK2 NTRK1
11 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.1 ROS1 NTRK3 NTRK2 NTRK1 CSF1R ALK

Sources for Malignant Giant Cell Tumor of the Tendon Sheath

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
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48 NCI
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57 OMIM via Orphanet
61 PubMed
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68 SNOMED-CT via HPO
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70 Tocris
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72 UMLS via Orphanet
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