MCID: MLG032
MIFTS: 28

Malignant Granular Cell Myoblastoma

Categories: Cancer diseases

Aliases & Classifications for Malignant Granular Cell Myoblastoma

MalaCards integrated aliases for Malignant Granular Cell Myoblastoma:

Name: Malignant Granular Cell Myoblastoma 12 15
Malignant Granular Cell Tumor 12 29 6 73
Malignant Granular Cell Neoplasm 12
Granular Cell Tumor, Malignant 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5042
NCIt 50 C4336
SNOMED-CT 68 13238004 404041003
UMLS 73 C0334618

Summaries for Malignant Granular Cell Myoblastoma

MalaCards based summary : Malignant Granular Cell Myoblastoma, also known as malignant granular cell tumor, is related to malignant gastric granular cell tumor and malignant granular cell skin tumor. An important gene associated with Malignant Granular Cell Myoblastoma is GFRA2 (GDNF Family Receptor Alpha 2). The drugs Doxorubicin and Mechlorethamine have been mentioned in the context of this disorder. Affiliated tissues include colon, uterus and bone.

Related Diseases for Malignant Granular Cell Myoblastoma

Diseases related to Malignant Granular Cell Myoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 malignant gastric granular cell tumor 11.3
2 malignant granular cell skin tumor 11.1
3 myoblastoma 10.5
4 granular cell tumor 10.2
5 neurilemmoma 9.8 ENO2 SOX10
6 oligodendroglioma 9.7 ENO2 SOX10
7 hirschsprung disease 1 9.5 GFRA2 SOX10

Graphical network of the top 20 diseases related to Malignant Granular Cell Myoblastoma:



Diseases related to Malignant Granular Cell Myoblastoma

Symptoms & Phenotypes for Malignant Granular Cell Myoblastoma

Drugs & Therapeutics for Malignant Granular Cell Myoblastoma

Drugs for Malignant Granular Cell Myoblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
2
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
3
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
4
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
5
Doxil Approved June 1999 Phase 2, Phase 3 31703
6
Isophosphamide mustard Phase 2, Phase 3 0
7 Alkylating Agents Phase 2, Phase 3
8 Topoisomerase Inhibitors Phase 2, Phase 3
9 Anti-Bacterial Agents Phase 2, Phase 3
10 Antibiotics, Antitubercular Phase 2, Phase 3
11 Antineoplastic Agents, Alkylating Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride

Search NIH Clinical Center for Malignant Granular Cell Myoblastoma

Genetic Tests for Malignant Granular Cell Myoblastoma

Genetic tests related to Malignant Granular Cell Myoblastoma:

# Genetic test Affiliating Genes
1 Malignant Granular Cell Tumor 29

Anatomical Context for Malignant Granular Cell Myoblastoma

MalaCards organs/tissues related to Malignant Granular Cell Myoblastoma:

41
Colon, Uterus, Bone

Publications for Malignant Granular Cell Myoblastoma

Articles related to Malignant Granular Cell Myoblastoma:

(show top 50) (show all 66)
# Title Authors Year
1
18F-FDG PET/CT and MRI of a Mediastinal Malignant Granular Cell Tumor With Associated Recurrent Pericarditis. ( 29847320 )
2018
2
Malignant granular cell tumor of the median nerve: a case report with a literature review of 157 cases. ( 29980826 )
2018
3
Large malignant granular cell tumor with suprascapular nerve and brachial plexus invasion: A case report and literature review. ( 29095317 )
2017
4
Malignant granular cell tumor of the foot-multimodality imaging findings and literature review. ( 25487437 )
2015
5
Malignant granular cell tumor of the breast; literature review. ( 25885145 )
2015
6
Whole-genome sequencing of a malignant granular cell tumor with metabolic response to pazopanib. ( 27148567 )
2015
7
Primary cutaneous malignant granular cell tumor: a case report in China and review of the literature. ( 26187381 )
2015
8
Primary cutaneous malignant granular cell tumor: an immunohistochemical study and review of the literature. ( 25794371 )
2015
9
Malignant granular cell tumor of the back: a case report and review of the literature. ( 25506365 )
2014
10
A case of malignant granular cell tumor in the sigmoid colon. ( 24765605 )
2014
11
Giant malignant granular cell tumor (GCT) of the posterior mediastinum. ( 23857402 )
2013
12
A Rare Case of Malignant Granular Cell Tumor of the Colon Incidentally Detected by (18)a88F-FDG Positron Emission Tomography/Computed Tomography. ( 24900100 )
2013
13
A Rare Case of Pulmonary Malignant Granular Cell Tumor Detected With 18F-FDG PET/CT Imaging. ( 24300348 )
2013
14
Malignant granular cell tumor of the posterior mediastinum with dissemination. ( 22371949 )
2012
15
Malignant granular cell tumor with breast metastasis: A case report and review of the literature. ( 22807961 )
2012
16
Malignant granular cell tumor of the breast: case report and literature review. ( 22467405 )
2012
17
A malignant granular cell tumor excised with mohs micrographic surgery. ( 22606454 )
2012
18
Uterine cervical malignant granular cell tumor. ( 22414028 )
2012
19
Malignant granular cell tumor: a look into the diagnostic criteria. ( 21282016 )
2011
20
Malignant granular cell tumor of the thigh. ( 21815590 )
2011
21
Diagnosis of malignant granular cell tumor metastatic to bone by fine needle aspiration cytology: a case report. ( 20391977 )
2010
22
Malignant granular cell tumor in the gluteal region with unusual pathologic features. ( 21309422 )
2010
23
Malignant granular cell tumor: case report with a novel karyotype and review of the literature. ( 20637434 )
2010
24
Malignant granular cell tumor of the anal-perianal region and suprarenal hyperplasia: a casual association? ( 21430904 )
2010
25
Malignant granular cell tumor of the ulnar nerve with novel cytogenetic and molecular genetic findings. ( 19389509 )
2009
26
Malignant granular cell tumor of the skull base. ( 18592017 )
2008
27
Malignant granular cell tumor with unusual histological features. ( 17300677 )
2007
28
Malignant granular cell tumor of the abdominal wall. ( 16259279 )
2005
29
Malignant granular cell tumor of the esophagus. ( 14745554 )
2004
30
Malignant granular cell tumor in larynx mimicking laryngeal carcinoma. ( 15239036 )
2004
31
Contrast-enhanced magnetic resonance imaging of malignant granular cell tumor with pathological correlation: a case report. ( 15449131 )
2004
32
Unusual presentation of a malignant granular cell tumor of the pelvis: case report and literature review. ( 12821371 )
2003
33
Pulmonary malignant granular cell tumor. ( 14613555 )
2003
34
Malignant granular cell tumor of the lateral femoral cutaneous nerve: report of a case with cytogenetic analysis. ( 12514794 )
2002
35
Cytologic findings in granular cell tumors, with emphasis on the diagnosis of malignant granular cell tumor by fine-needle aspiration biopsy. ( 11748580 )
2001
36
Diagnosis of malignant granular cell tumor by fine needle aspiration cytology:. ( 11726096 )
2001
37
Malignant granular cell tumor of soft tissues: a study of two new cases. ( 11584326 )
2001
38
Malignant granular cell tumor of the masseter muscle: case report. ( 10716122 )
2000
39
Malignant granular cell tumor metastatic to the orbit. ( 10711894 )
2000
40
Malignant granular cell tumor of the vulva in a 17-year-old: Case report and literature review. ( 11240710 )
2000
41
Malignant granular cell tumor at the retrotracheal space. ( 10198610 )
1999
42
Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. ( 9669341 )
1998
43
Malignant granular cell tumor: report of a case and review of the literature. ( 9728367 )
1998
44
Intramuscular malignant granular cell tumor. ( 9060104 )
1997
45
Malignant granular cell tumor mimicking herniated nucleus pulposus. ( 8595764 )
1996
46
Malignant granular cell tumor. Report of a case with DNA ploidy analysis. ( 8629910 )
1996
47
A malignant granular cell tumor of the stomach: report of a case. ( 8919282 )
1996
48
Malignant granular cell tumor: a case report and review of the recent literature. ( 8760023 )
1996
49
Malignant granular cell tumor. ( 7655805 )
1995
50
Malignant granular cell tumor. ( 7962829 )
1994

Variations for Malignant Granular Cell Myoblastoma

ClinVar genetic disease variations for Malignant Granular Cell Myoblastoma:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BRD7 NM_001173984.2(BRD7): c.1837C> T (p.Arg613Ter) single nucleotide variant Likely pathogenic rs796065051 GRCh38 Chromosome 16, 50319953: 50319953
2 BRD7 NM_001173984.2(BRD7): c.1837C> T (p.Arg613Ter) single nucleotide variant Likely pathogenic rs796065051 GRCh37 Chromosome 16, 50353864: 50353864

Expression for Malignant Granular Cell Myoblastoma

Search GEO for disease gene expression data for Malignant Granular Cell Myoblastoma.

Pathways for Malignant Granular Cell Myoblastoma

GO Terms for Malignant Granular Cell Myoblastoma

Cellular components related to Malignant Granular Cell Myoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 myelin sheath GO:0043209 8.62 ENO2 MAG

Biological processes related to Malignant Granular Cell Myoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of myelination GO:0031643 8.96 MAG SOX10
2 central nervous system myelination GO:0022010 8.62 MAG SOX10

Molecular functions related to Malignant Granular Cell Myoblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lyase activity GO:0016829 8.62 ENO2 HCCS

Sources for Malignant Granular Cell Myoblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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