MCID: MLG144
MIFTS: 29

Malignant Hemangioma

Categories: Blood diseases, Cancer diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Malignant Hemangioma

MalaCards integrated aliases for Malignant Hemangioma:

Name: Malignant Hemangioma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0080189
ICD10 33 D18 D18.0
UMLS 73 C0474836

Summaries for Malignant Hemangioma

Disease Ontology : 12 A cell type cancer of vascular origin, characterized by proliferation of endothelial cells in and about the vascular lumen.

MalaCards based summary : Malignant Hemangioma is related to malignant epithelioid hemangioendothelioma and hemangioma. An important gene associated with Malignant Hemangioma is RASGEF1B (RasGEF Domain Family Member 1B), and among its related pathways/superpathways are Immune response IFN alpha/beta signaling pathway and Immune response IFN gamma signaling pathway. Affiliated tissues include endothelial, bone and skin.

Related Diseases for Malignant Hemangioma

Diseases in the Hemangioma family:

Malignant Hemangioma Acquired Hemangioma
Familial Hemangioma

Diseases related to Malignant Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 malignant epithelioid hemangioendothelioma 30.0 CAMTA1 CD34 FLT4 FOLH1 KDR MYC
2 hemangioma 29.9 CD34 FLT4 KDR
3 hemangioma of spleen 10.2 FLT4 SMUG1
4 anthracosilicosis 10.2 FOLH1 SMUG1
5 nodular prostate 10.1 FOLH1 KDR
6 hemangioendothelioma 10.1 CAMTA1 FLT4 KDR
7 spleen angiosarcoma 10.1 CD34 SMUG1
8 tibial adamantinoma 10.1 CD34 SMUG1
9 sternum cancer 10.1 CD34 SMUG1
10 breast leiomyosarcoma 10.1 CD34 SMUG1
11 hobnail hemangioma 10.1 CD34 FLT4
12 ovary sarcoma 10.1 CD34 MYC
13 bone epithelioid hemangioma 10.1 CD34 SMUG1
14 ovarian angiosarcoma 10.1 CD34 MYC
15 conventional angiosarcoma 10.1 CAMTA1 CD34
16 angiosarcoma 10.1 FLT4 KDR MYC
17 reproductive system disease 10.0 FOLH1 MYC SMUG1
18 eccrine adenocarcinoma 10.0 CD34 SMUG1
19 venous hemangioma 10.0 CD34 MYC
20 hemangioma, capillary infantile 10.0 FLT4 KDR
21 breast angiosarcoma 10.0 CD34 SMUG1
22 kaposiform hemangioendothelioma 10.0 CD34 FLT4 KDR
23 endocrine gland cancer 10.0 KDR MYC SMUG1
24 senile angioma 10.0 CD34 KDR
25 interstitial emphysema 10.0 CD34 FLT4
26 leukocyte disease 10.0 CD34 MYC SMUG1
27 vascular cancer 9.9 CAMTA1 CD34 FLT4 KDR
28 gastric adenocarcinoma 9.9 KDR MYC SMUG1 YAP1
29 alveoli adenoma 9.9 CD34 FLT4
30 lymphangiosarcoma 9.9 CD34 FLT4 MYC SMUG1
31 gastrointestinal system cancer 9.8 CD34 KDR MYC SMUG1
32 sarcomatoid squamous cell skin carcinoma 9.8 CAMTA1 CD34 TFE3
33 large intestine cancer 9.8 CD34 KDR MYC SMUG1
34 epithelioid hemangioendothelioma 9.6 CAMTA1 KDR TFE3 WWTR1 YAP1
35 liver angiosarcoma 9.5 CAMTA1 CD34 TFE3 WWTR1 YAP1
36 chromosome 4q21 deletion syndrome 9.4 BMP3 ENOPH1 HNRNPD HNRNPDL LINC00575 PRKG2

Graphical network of the top 20 diseases related to Malignant Hemangioma:



Diseases related to Malignant Hemangioma

Symptoms & Phenotypes for Malignant Hemangioma

Drugs & Therapeutics for Malignant Hemangioma

Search Clinical Trials , NIH Clinical Center for Malignant Hemangioma

Genetic Tests for Malignant Hemangioma

Anatomical Context for Malignant Hemangioma

MalaCards organs/tissues related to Malignant Hemangioma:

41
Endothelial, Bone, Skin, Liver, Ovary, Spleen, Prostate

Publications for Malignant Hemangioma

Articles related to Malignant Hemangioma:

# Title Authors Year
1
A de novo microtriplication at 4q21.21-q21.22 in a patient with a vascular malignant hemangioma, elongated sigmoid colon, developmental delay, and absence of speech. ( 27288323 )
2016
2
Malignant hemangioma-endothelioma of bone presenting as Tietze's syndrome. ( 6022400 )
1967
3
A Malignant Hemangioma of the Lung with Multiple Metastases. ( 19970203 )
1935

Variations for Malignant Hemangioma

Expression for Malignant Hemangioma

Search GEO for disease gene expression data for Malignant Hemangioma.

Pathways for Malignant Hemangioma

Pathways related to Malignant Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.77 BMP3 FLT4 KDR MYC
2
Show member pathways
11.68 BMP3 FLT4 KDR MYC
3 11.09 FLT4 KDR WWTR1 YAP1
4 10.76 FLT4 KDR MYC
5 10.64 WWTR1 YAP1
6
Show member pathways
10.36 FLT4 KDR

GO Terms for Malignant Hemangioma

Biological processes related to Malignant Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.85 FLT4 KDR MYC WWTR1 YAP1
2 negative regulation of gene expression GO:0010629 9.73 CD34 HNRNPD KDR MYC
3 vascular endothelial growth factor signaling pathway GO:0038084 9.48 FLT4 KDR
4 regulation of telomere maintenance GO:0032204 9.4 HNRNPD MYC
5 positive regulation of vasculogenesis GO:2001214 9.37 CD34 KDR
6 endothelium development GO:0003158 9.32 CD34 KDR
7 regulation of metanephric nephron tubule epithelial cell differentiation GO:0072307 9.26 WWTR1 YAP1
8 heart process GO:0003015 9.16 WWTR1 YAP1
9 cellular response to putrescine GO:1904586 8.96 HNRNPD MYC
10 tissue homeostasis GO:0001894 8.8 CD34 WWTR1 YAP1

Molecular functions related to Malignant Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vascular endothelial growth factor-activated receptor activity GO:0005021 8.62 FLT4 KDR

Sources for Malignant Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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