MCID: MLG020
MIFTS: 19

Malignant Histiocytic Disease

Categories: Cancer diseases, Immune diseases

Aliases & Classifications for Malignant Histiocytic Disease

MalaCards integrated aliases for Malignant Histiocytic Disease:

Name: Malignant Histiocytic Disease 12 15
Histiocytic Disorders, Malignant 44

Classifications:



External Ids:

Disease Ontology 12 DOID:2570
MeSH 44 D015620
SNOMED-CT 67 127070008
UMLS 71 C0019613

Summaries for Malignant Histiocytic Disease

MalaCards based summary : Malignant Histiocytic Disease, also known as histiocytic disorders, malignant, is related to predominantly cortical thymoma and tolosa-hunt syndrome. An important gene associated with Malignant Histiocytic Disease is CD1A (CD1a Molecule), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Tight junction.

Related Diseases for Malignant Histiocytic Disease

Diseases related to Malignant Histiocytic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 predominantly cortical thymoma 10.0 CD1E CD1A
2 tolosa-hunt syndrome 10.0 CD1E CD1A
3 dendritic cell thymoma 10.0 CD1E CD1A
4 multifocal motor neuropathy 9.9 CD1E CD1A
5 oral hairy leukoplakia 9.9 CD1E CD1A
6 histiocytosis 9.9 CD1C CD1A
7 pityriasis rosea 9.9 CD1E CD1A
8 kimura disease 9.9 CD1E CD1A
9 juvenile xanthogranuloma 9.8 CD1E CD1A
10 mite infestation 9.8 CD1B CD1A
11 skin sarcoidosis 9.7 CD1C CD1B
12 phlyctenulosis 9.7 CD1E CD1B CD1A
13 mixed type thymoma 9.7 CD1E CD1B CD1A
14 encapsulated thymoma 9.7 CD1E CD1B CD1A
15 sphenoid sinusitis 9.7 CD1E CD1B CD1A
16 epithelial malignant thymoma 9.7 CD1E CD1B CD1A
17 necrobiosis lipoidica 9.7 CD1E CD1B CD1A
18 langerhans cell histiocytosis 9.5 CD1C CD1A
19 granulomatous dermatitis 9.4 CD1E CD1C CD1B
20 mycobacterium tuberculosis 1 9.4 CD1C CD1B CD1A
21 chronic laryngitis 9.4 CD1E CD1D CD1B CD1A
22 acanthoma 9.3 CD1E CD1C CD1B CD1A
23 central nervous system sarcoma 9.3 CD1E CD1C CD1B CD1A
24 lichen nitidus 9.3 CD1E CD1C CD1B CD1A
25 interdigitating dendritic cell sarcoma 9.2 CD1E CD1C CD1B CD1A
26 seborrheic dermatitis 9.2 CD1E CD1C CD1B CD1A
27 fibrosarcoma of bone 9.2 CD1E CD1C CD1B CD1A
28 connective tissue benign neoplasm 9.2 CD1E CD1C CD1B CD1A
29 mycobacterium malmoense 9.0 CD1E CD1D CD1C CD1B CD1A
30 langerhans cell sarcoma 9.0 CD1E CD1D CD1C CD1B CD1A
31 diencephalic astrocytoma 9.0 CD1E CD1D CD1C CD1B CD1A
32 spongiotic dermatitis 9.0 CD1E CD1D CD1C CD1B CD1A
33 reticulohistiocytic granuloma 9.0 CD1E CD1D CD1C CD1B CD1A
34 orbital cancer 9.0 CD1E CD1D CD1C CD1B CD1A
35 granuloma annulare 9.0 CD1E CD1D CD1C CD1B CD1A
36 inflamed seborrheic keratosis 9.0 CD1E CD1D CD1C CD1B CD1A
37 rhinoscleroma 9.0 CD1E CD1D CD1C CD1B CD1A
38 marginal corneal ulcer 9.0 CD1E CD1D CD1C CD1B CD1A
39 balloon cell malignant melanoma 9.0 CD1E CD1D CD1C CD1B CD1A
40 central epithelioid sarcoma 9.0 CD1E CD1D CD1C CD1B CD1A
41 vulvar proximal-type epithelioid sarcoma 9.0 CD1E CD1D CD1C CD1B CD1A
42 histiocytic and dendritic cell cancer 9.0 CD1E CD1D CD1C CD1B CD1A
43 non-langerhans-cell histiocytosis 9.0 CD1E CD1D CD1C CD1B CD1A
44 pilar sheath acanthoma 9.0 CD1E CD1D CD1C CD1B CD1A
45 diencephalic neoplasm 9.0 CD1E CD1D CD1C CD1B CD1A
46 polyclonal hypergammaglobulinemia 9.0 CD1E CD1D CD1C CD1B CD1A
47 acute dacryocystitis 9.0 CD1E CD1D CD1C CD1B CD1A
48 adult xanthogranuloma 9.0 CD1E CD1D CD1C CD1B CD1A
49 erdheim-chester disease 9.0 CD1E CD1D CD1C CD1B CD1A
50 psoriasis 15 9.0 CD1E CD1D CD1C CD1B CD1A

Graphical network of the top 20 diseases related to Malignant Histiocytic Disease:



Diseases related to Malignant Histiocytic Disease

Symptoms & Phenotypes for Malignant Histiocytic Disease

Drugs & Therapeutics for Malignant Histiocytic Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study to Assess the Safety and Efficacy of Cobimetinib in Refractory Langerhans Cell Histiocytosis, LCH-Associated Neurodegenerative Disease, and Other Histiocytic Disorders. Not yet recruiting NCT04079179 Phase 2 Cobimetinib

Search NIH Clinical Center for Malignant Histiocytic Disease

Cochrane evidence based reviews: histiocytic disorders, malignant

Genetic Tests for Malignant Histiocytic Disease

Anatomical Context for Malignant Histiocytic Disease

Publications for Malignant Histiocytic Disease

Variations for Malignant Histiocytic Disease

Expression for Malignant Histiocytic Disease

Search GEO for disease gene expression data for Malignant Histiocytic Disease.

Pathways for Malignant Histiocytic Disease

GO Terms for Malignant Histiocytic Disease

Cellular components related to Malignant Histiocytic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.8 CD1E CD1D CD1C CD1B CD1A
2 extracellular space GO:0005615 9.72 CD1E CD1D CD1C CD1B CD1A
3 integral component of plasma membrane GO:0005887 9.67 CD1E CD1D CD1C CD1A
4 lysosome GO:0005764 9.56 CD1E CD1D CD1C CD1B
5 endosome membrane GO:0010008 9.46 CD1D CD1C CD1B CD1A
6 endosome GO:0005768 9.35 CD1E CD1D CD1C CD1B CD1A
7 external side of plasma membrane GO:0009897 9.02 CD1E CD1D CD1C CD1B CD1A

Biological processes related to Malignant Histiocytic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 CD1E CD1D CD1C CD1B CD1A
2 adaptive immune response GO:0002250 9.71 CD1E CD1C CD1B CD1A
3 immune response GO:0006955 9.65 CD1E CD1D CD1C CD1B CD1A
4 regulation of immune response GO:0050776 9.62 CD1D CD1C CD1B CD1A
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
6 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
7 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Malignant Histiocytic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Malignant Histiocytic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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