MCID: MLG020
MIFTS: 20

Malignant Histiocytic Disease

Categories: Immune diseases

Aliases & Classifications for Malignant Histiocytic Disease

MalaCards integrated aliases for Malignant Histiocytic Disease:

Name: Malignant Histiocytic Disease 12 15
Histiocytic Disorders, Malignant 43

Classifications:



External Ids:

Disease Ontology 12 DOID:2570
MeSH 43 D015620
UMLS 71 C0019613

Summaries for Malignant Histiocytic Disease

MalaCards based summary : Malignant Histiocytic Disease, also known as histiocytic disorders, malignant, is related to malignant histiocytosis and verruciform xanthoma of skin. An important gene associated with Malignant Histiocytic Disease is CD1A (CD1a Molecule), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Tight junction. Affiliated tissues include thymus, skin and bone.

Related Diseases for Malignant Histiocytic Disease

Diseases related to Malignant Histiocytic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 malignant histiocytosis 29.4 CD1E CD1A
2 verruciform xanthoma of skin 9.9 CD1E CD1A
3 multifocal motor neuropathy 9.9 CD1E CD1A
4 thymus lipoma 9.9 CD1B CD1A
5 interstitial pneumonitis, desquamative, familial 9.9 CD1E CD1A
6 immune system organ benign neoplasm 9.9 CD1B CD1A
7 histiocytosis 9.8 CD1C CD1A
8 pancytopenia 9.8
9 histiocytoma 9.8
10 mite infestation 9.7 CD1B CD1A
11 central nervous system sarcoma 9.5 CD1E CD1B CD1A
12 lichen nitidus 9.5 CD1E CD1B CD1A
13 cortical thymoma 9.5 CD1E CD1B CD1A
14 dendritic cell thymoma 9.5 CD1E CD1B CD1A
15 juvenile xanthogranuloma 9.5 CD1E CD1B CD1A
16 dermis tumor 9.5 CD1E CD1B CD1A
17 bone benign neoplasm 9.5 CD1E CD1B CD1A
18 folliculitis 9.5 CD1E CD1B CD1A
19 langerhans cell histiocytosis 9.4 CD1C CD1A
20 acute t cell leukemia 9.4 CD1E CD1B
21 mycosis fungoides 9.2 CD1C CD1B CD1A
22 leprosy 3 9.2 CD1E CD1C CD1B
23 mycobacterium tuberculosis 1 9.1 CD1C CD1B CD1A
24 encapsulated thymoma 9.0 CD1E CD1C CD1B CD1A
25 precursor lymphoblastic lymphoma/leukemia 9.0 CD1E CD1C CD1B CD1A
26 skin sarcoidosis 9.0 CD1E CD1C CD1B CD1A
27 interdigitating dendritic cell sarcoma 9.0 CD1E CD1C CD1B CD1A
28 orbital cancer 8.9 CD1E CD1C CD1B CD1A
29 polyclonal hypergammaglobulinemia 8.9 CD1E CD1C CD1B CD1A
30 erdheim-chester disease 8.9 CD1E CD1C CD1B CD1A
31 seborrheic dermatitis 8.9 CD1E CD1C CD1B CD1A
32 diabetes insipidus, neurohypophyseal 8.9 CD1E CD1C CD1B CD1A
33 keratosis, seborrheic 8.9 CD1E CD1C CD1B CD1A
34 thymus cancer 8.9 CD1E CD1C CD1B CD1A
35 meningioma, familial 8.9 CD1E CD1C CD1B CD1A
36 mycobacterium malmoense 8.6 CD1E CD1D CD1C CD1B CD1A
37 langerhans cell sarcoma 8.6 CD1E CD1D CD1C CD1B CD1A
38 precursor t-lymphoblastic lymphoma/leukemia 8.6 CD1E CD1D CD1C CD1B CD1A
39 spongiotic dermatitis 8.6 CD1E CD1D CD1C CD1B CD1A
40 reticulohistiocytic granuloma 8.6 CD1E CD1D CD1C CD1B CD1A
41 granuloma annulare 8.6 CD1E CD1D CD1C CD1B CD1A
42 inflamed seborrheic keratosis 8.6 CD1E CD1D CD1C CD1B CD1A
43 rhinoscleroma 8.6 CD1E CD1D CD1C CD1B CD1A
44 balloon cell malignant melanoma 8.6 CD1E CD1D CD1C CD1B CD1A
45 histiocytic and dendritic cell cancer 8.6 CD1E CD1D CD1C CD1B CD1A
46 non-langerhans-cell histiocytosis 8.6 CD1E CD1D CD1C CD1B CD1A
47 adult xanthogranuloma 8.6 CD1E CD1D CD1C CD1B CD1A
48 central epithelioid sarcoma 8.6 CD1E CD1D CD1C CD1B CD1A
49 vulvar proximal-type epithelioid sarcoma 8.6 CD1E CD1D CD1C CD1B CD1A
50 lichen disease 8.6 CD1E CD1D CD1C CD1B CD1A

Graphical network of the top 20 diseases related to Malignant Histiocytic Disease:



Diseases related to Malignant Histiocytic Disease

Symptoms & Phenotypes for Malignant Histiocytic Disease

Drugs & Therapeutics for Malignant Histiocytic Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study to Assess the Safety and Efficacy of Cobimetinib in Refractory Langerhans Cell Histiocytosis, LCH-Associated Neurodegenerative Disease, and Other Histiocytic Disorders. Not yet recruiting NCT04079179 Phase 2 Cobimetinib

Search NIH Clinical Center for Malignant Histiocytic Disease

Cochrane evidence based reviews: histiocytic disorders, malignant

Genetic Tests for Malignant Histiocytic Disease

Anatomical Context for Malignant Histiocytic Disease

MalaCards organs/tissues related to Malignant Histiocytic Disease:

40
Thymus, Skin, Bone, T Cells

Publications for Malignant Histiocytic Disease

Variations for Malignant Histiocytic Disease

Expression for Malignant Histiocytic Disease

Search GEO for disease gene expression data for Malignant Histiocytic Disease.

Pathways for Malignant Histiocytic Disease

GO Terms for Malignant Histiocytic Disease

Cellular components related to Malignant Histiocytic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.83 CD1E CD1D CD1C CD1B CD1A
2 plasma membrane GO:0005886 9.8 CD1E CD1D CD1C CD1B CD1A
3 extracellular space GO:0005615 9.72 CD1E CD1D CD1C CD1B CD1A
4 integral component of plasma membrane GO:0005887 9.67 CD1E CD1D CD1C CD1A
5 lysosome GO:0005764 9.56 CD1E CD1D CD1C CD1B
6 endosome membrane GO:0010008 9.46 CD1D CD1C CD1B CD1A
7 endosome GO:0005768 9.35 CD1E CD1D CD1C CD1B CD1A
8 external side of plasma membrane GO:0009897 9.02 CD1E CD1D CD1C CD1B CD1A

Biological processes related to Malignant Histiocytic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.72 CD1E CD1D CD1C CD1B CD1A
2 adaptive immune response GO:0002250 9.71 CD1E CD1C CD1B CD1A
3 regulation of immune response GO:0050776 9.67 CD1D CD1C CD1B CD1A
4 immune response GO:0006955 9.65 CD1E CD1D CD1C CD1B CD1A
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1E CD1D CD1C CD1B CD1A
6 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1E CD1D CD1C CD1B CD1A
7 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1E CD1D CD1C CD1B CD1A

Molecular functions related to Malignant Histiocytic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1E CD1D CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.35 CD1E CD1D CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 9.02 CD1E CD1D CD1C CD1B CD1A

Sources for Malignant Histiocytic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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