MCID: MLG054
MIFTS: 50

Malignant Histiocytosis

Categories: Immune diseases, Cancer diseases, Respiratory diseases, Bone diseases, Blood diseases, Rare diseases

Aliases & Classifications for Malignant Histiocytosis

MalaCards integrated aliases for Malignant Histiocytosis:

Name: Malignant Histiocytosis 12 55 15 73
Histiocytic Medullary Reticulosis 12 29 6 73
Histiocytic Sarcoma 44 73
Nasal Type Extranodal Nk/t-Cell Lymphoma 73
Malignant Midline Reticulosis 12
Malignant Reticulosis 12
Stewart's Granuloma 12

Classifications:



Summaries for Malignant Histiocytosis

MalaCards based summary : Malignant Histiocytosis, also known as histiocytic medullary reticulosis, is related to histiocytosis and acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22), and has symptoms including fever and malaise. An important gene associated with Malignant Histiocytosis is RAG1 (Recombination Activating 1), and among its related pathways/superpathways are ERK Signaling and Innate Immune System. Affiliated tissues include t cells, spleen and lymph node, and related phenotypes are hematopoietic system and immune system

Wikipedia : 76 Malignant histiocytosis (also known as \"Histiocytic medullary reticulosis\") is a rare hereditary... more...

Related Diseases for Malignant Histiocytosis

Diseases in the Histiocytosis family:

Malignant Histiocytosis

Diseases related to Malignant Histiocytosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 histiocytosis 32.0 CSF1R SERPINA3 TNFRSF8
2 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 30.3 CSF1 CSF1R
3 omenn syndrome 30.0 DCLRE1C RAG1 RAG2
4 t-cell leukemia 28.9 FOS LTA MYC TNFRSF8
5 rheumatoid arthritis 28.7 CSF1 CSF1R FOS IL1A TFRC
6 extranodal nasal nk/t cell lymphoma 11.2
7 polymorphic reticulosis 11.0
8 langerhans cell sarcoma 10.9
9 myasthenic syndrome, congenital, 4c, associated with acetylcholine receptor deficiency 10.6 CSF1R MYB
10 chronic venous leg ulcers 10.6 LTA MYC
11 leukoregulin 10.5 CSF1 IL1A
12 adult lymphoma 10.5 MYC TNFRSF8
13 tenosynovial giant cell tumor 10.5 CSF1 CSF1R SERPINA3
14 marcus gunn phenomenon 10.5 FOS MYC
15 bone ewing's sarcoma 10.4 MYB MYC PDGFB
16 malignant fibrous histiocytoma of bone 10.4 FOS MYC
17 lymphoma 10.4
18 hantavirus pulmonary syndrome 10.3 IL1A LTA
19 jaw cancer 10.3 CSF1 IL1A
20 cutaneous fibrous histiocytoma 10.3 PDGFB SERPINA3
21 granulomatous myositis 10.3 LYZ TNFRSF8
22 liver sarcoma 10.2 LYZ PDGFB
23 leukemia 10.2
24 cutaneous solitary mastocytoma 10.2 LYZ SERPINA3
25 stachybotrys chartarum 10.2 CSF1 IL1A
26 lymphatic system cancer 10.1 LYZ MYC TNFRSF8
27 reticulohistiocytic granuloma 10.1 LYZ SERPINA3 TNFRSF8
28 hematologic cancer 10.1 CSF1 CSF1R MYC TNFRSF8
29 virus associated hemophagocytic syndrome 10.1
30 hemophagocytic syndrome associated with an infection 10.1
31 dermis tumor 10.1 LYZ PDGFB SERPINA3
32 recombinase activating gene 1 deficiency 10.0 RAG1 RAG2
33 pigmented villonodular synovitis 10.0 CSF1 CSF1R
34 combined cellular and humoral immune defects with granulomas 10.0 RAG1 RAG2
35 sarcoma 9.9
36 mediastinitis 9.9
37 severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-negative 9.9 RAG1 RAG2
38 b-cell lymphomas 9.9
39 lymphosarcoma 9.9
40 lethal midline granuloma 9.9
41 germ cells tumors 9.9
42 acute lymphocytic leukemia 9.8
43 hepatitis 9.8
44 lymphoblastic lymphoma 9.8
45 leishmaniasis 9.8
46 parapsoriasis 9.8
47 leukemia, chronic lymphocytic 2 9.7
48 leukemia, chronic lymphocytic 9.7
49 systemic lupus erythematosus 9.7
50 malaria 9.7

Graphical network of the top 20 diseases related to Malignant Histiocytosis:



Diseases related to Malignant Histiocytosis

Symptoms & Phenotypes for Malignant Histiocytosis

UMLS symptoms related to Malignant Histiocytosis:


fever, malaise

MGI Mouse Phenotypes related to Malignant Histiocytosis:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.36 IL1A LTA DCLRE1C CSF1 FOS CSF1R
2 immune system MP:0005387 10.32 CSF1R IL1A LTA DCLRE1C CSF1 FOS
3 endocrine/exocrine gland MP:0005379 10.29 CSF1R LTA DCLRE1C CSF1 FOS MYB
4 growth/size/body region MP:0005378 10.28 CSF1R CSF1 FOS PDGFB MYB LTA
5 cardiovascular system MP:0005385 10.27 IL1A LTA CSF1 PDGFB MYB MYC
6 cellular MP:0005384 10.26 CSF1R DCLRE1C CSF1 FOS MYB MYC
7 homeostasis/metabolism MP:0005376 10.24 IL1A CSF1R CSF1 FOS LTA MYC
8 integument MP:0010771 10.2 CSF1R IL1A CSF1 FOS PDGFB MYB
9 mortality/aging MP:0010768 10.14 CSF1R CSF1 FOS MYC LYZ LTA
10 liver/biliary system MP:0005370 10.09 LTA CSF1 PDGFB MYB MYC LYZ
11 nervous system MP:0003631 10.02 CSF1R CSF1 FOS PDGFB LTA MYC
12 hearing/vestibular/ear MP:0005377 9.92 CSF1R CSF1 FOS MYC RAG1
13 neoplasm MP:0002006 9.85 IL1A FOS MYC LYZ RAG1 RAG2
14 no phenotypic analysis MP:0003012 9.8 CSF1R CSF1 MYB MYC LYZ PDGFB
15 normal MP:0002873 9.76 CSF1R FOS LYZ MYB MYC RAG2
16 respiratory system MP:0005388 9.43 CSF1 LYZ LTA RAG1 PDGFB RAG2
17 skeleton MP:0005390 9.23 CSF1R CSF1 FOS MYC LYZ LTA

Drugs & Therapeutics for Malignant Histiocytosis

Search Clinical Trials , NIH Clinical Center for Malignant Histiocytosis

Cochrane evidence based reviews: histiocytic sarcoma

Genetic Tests for Malignant Histiocytosis

Genetic tests related to Malignant Histiocytosis:

# Genetic test Affiliating Genes
1 Histiocytic Medullary Reticulosis 29 DCLRE1C RAG1 RAG2

Anatomical Context for Malignant Histiocytosis

MalaCards organs/tissues related to Malignant Histiocytosis:

41
T Cells, Spleen, Lymph Node, Liver, Lung, Bone, Bone Marrow

Publications for Malignant Histiocytosis

Articles related to Malignant Histiocytosis:

(show top 50) (show all 356)
# Title Authors Year
1
Alemtuzumab-based therapy for Secondary Malignant Histiocytosis arising from Pre-B-ALL. ( 29264111 )
2018
2
Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. ( 22236140 )
2012
3
Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis). ( 21617208 )
2011
4
Malignant histiocytosis and other causes of death in Bernese mountain dogs in Denmark. ( 20154310 )
2010
5
Evaluation of liposomal clodronate for treatment of malignant histiocytosis in dogs. ( 19760220 )
2010
6
Malignant histiocytosis of the skin: a case report and review of the literature. ( 21886719 )
2009
7
Morphological characterisation of malignant histiocytosis in a cat. ( 19085873 )
2008
8
Malignant histiocytosis with central nervous system involvement and hepatic mucinous cystadenoma in a single patient with review of the literature. ( 18067214 )
2007
9
Cytokine genes single nucleotide polymorphism (SNP) screening analyses in canine malignant histiocytosis. ( 17094461 )
2006
10
Malignant histiocytosis of the brain in three dogs. ( 16537081 )
2006
11
Malignant histiocytosis: a case report of a rare tumour presenting with spontaneous splenic rupture. ( 16803951 )
2006
12
True malignant histiocytosis with trisomy 9 following primary mediastinal germ cell tumor. ( 16809892 )
2006
13
Growth characteristics of canine distemper virus in a new cell line CCT cells originated from canine malignant histiocytosis. ( 15750320 )
2005
14
A comparative pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs. ( 14709820 )
2003
15
Establishment of a new canine cell line (CCT) originated from a cutaneous malignant histiocytosis. ( 12867736 )
2003
16
Ultrasonographic features of canine abdominal malignant histiocytosis. ( 11954812 )
2002
17
Unusual hematologic malignancies. Case 2. Mediastinal germ cell tumor, malignant histiocytosis, and acute leukemia. ( 12202675 )
2002
18
A case of true malignant histiocytosis: identification of histiocytic origin with use of immunohistochemical and immunocytogenetic methods. ( 12029539 )
2002
19
Malignant histiocytosis in 3 cats. ( 11380036 )
2001
20
Diffuse leptomeningeal malignant histiocytosis in the brain and spinal cord of a Tibetan Terrier. ( 11280379 )
2001
21
A case of malignant histiocytosis associated with skin involvement mimicking kwashiorkor. ( 11841654 )
2001
22
Malignant histiocytosis. ( 11138619 )
2001
23
Malignant histiocytosis in cattle. ( 11193337 )
2000
24
Primary malignant histiocytosis of the brain in a dog. ( 10373296 )
1999
25
An Asian variant of intravascular lymphomatosis: an updated review of malignant histiocytosis-like B-cell lymphoma. ( 10342574 )
1999
26
Malignant histiocytosis in childhood: A case report. ( 10527486 )
1999
27
Malignant histiocytosis. ( 10606869 )
1999
28
Genetic and immunological parameters governing in vivo susceptibility/resistance to retrovirally induced murine malignant histiocytosis. ( 9766624 )
1998
29
True malignant histiocytosis. ( 9621858 )
1998
30
Blast crisis of Ph1-CML, with the prevalent features of malignant histiocytosis. ( 9549930 )
1998
31
Malignant histiocytosis. Histologic, cytochemical, chromosomal, and molecular data with a nosologic discussion. ( 9561912 )
1998
32
Epstein-Barr virus (EBV)-induced CD30+ natural killer cell-type malignancy resembling malignant histiocytosis: malignant transformation in chronic active EBV infection associating hypogammaglobulinemia. ( 9211526 )
1997
33
Successful treatment of canine malignant histiocytosis with the human major histocompatibility complex nonrestricted cytotoxic T-cell line TALL-104. ( 9815565 )
1997
34
Malignant histiocytosis-like B-cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature. ( 9401080 )
1997
35
Cell behavior and signal molecule involvement in a case study of malignant histiocytosis: a negative model of morphine as an immunoregulator. ( 9395179 )
1997
36
Malignant histiocytosis in a domestic cat: cytomorphologic and immunohistochemical features. ( 12658595 )
1997
37
Malignant histiocytosis in a Bernese mountain dog presenting as a mandibular mass. ( 9028594 )
1997
38
Hepatic manifestation of malignant histiocytosis: a case study. ( 9055006 )
1996
39
Malignant fibrous histiocytoma and malignant histiocytosis in the dog--convergent or divergent phenotypic differentiation? ( 8952034 )
1996
40
Thyroid involvement by malignant histiocytosis of Langerhans' cell type. ( 8949575 )
1996
41
True malignant histiocytosis developed during chemotherapy for mediastinal immature teratoma. ( 8892599 )
1996
42
Malignant histiocytosis in leukemia phase: Case report and review of the literature. ( 17372473 )
1996
43
Malignant histiocytosis in three Bernese mountain dogs. ( 8735262 )
1996
44
Analysis of the Epstein-Barr viral genome in so-called malignant histiocytosis syndrome. ( 8809882 )
1996
45
Perturbations of multiple hemopoietic lineages in retrovirus-induced murine malignant histiocytosis. ( 7723406 )
1995
46
Hepatosinusoidal leukaemia/lymphoma consisting of Epstein-Barr virus-containing natural killer cell leukaemia/lymphoma and T-cell lymphoma; mimicking malignant histiocytosis. ( 7797196 )
1995
47
Macrophage colony-stimulating factor-producing malignant histiocytosis. ( 7794771 )
1995
48
Colonic histiocytic neoplasm mimicking malignant histiocytosis and presenting as intussusception. ( 7774901 )
1995
49
Malignant histiocytosis in a patient presenting with hepatic dysfunction and peliosis hepatis. ( 7872292 )
1995
50
Malignant histiocytosis derived from a common histiocyte clone in a patient with chronic Epstein-Barr virus infection. ( 8580809 )
1995

Variations for Malignant Histiocytosis

ClinVar genetic disease variations for Malignant Histiocytosis:

6
(show top 50) (show all 328)
# Gene Variation Type Significance SNP ID Assembly Location
1 DCLRE1C NM_001033855.2(DCLRE1C): c.103C> G (p.His35Asp) single nucleotide variant Pathogenic rs121908159 GRCh37 Chromosome 10, 14995907: 14995907
2 DCLRE1C NM_001033855.2(DCLRE1C): c.103C> G (p.His35Asp) single nucleotide variant Pathogenic rs121908159 GRCh38 Chromosome 10, 14953908: 14953908
3 DCLRE1C NM_001033855.2(DCLRE1C): c.2T> C (p.Met1Thr) single nucleotide variant Pathogenic rs121908158 GRCh37 Chromosome 10, 14996008: 14996008
4 DCLRE1C NM_001033855.2(DCLRE1C): c.2T> C (p.Met1Thr) single nucleotide variant Pathogenic rs121908158 GRCh38 Chromosome 10, 14954009: 14954009
5 RAG2 NM_000536.3(RAG2): c.686G> A (p.Arg229Gln) single nucleotide variant Pathogenic rs121917894 GRCh37 Chromosome 11, 36615033: 36615033
6 RAG2 NM_000536.3(RAG2): c.686G> A (p.Arg229Gln) single nucleotide variant Pathogenic rs121917894 GRCh38 Chromosome 11, 36593483: 36593483
7 RAG2 NM_000536.3(RAG2): c.123C> G (p.Cys41Trp) single nucleotide variant Pathogenic rs121917895 GRCh37 Chromosome 11, 36615596: 36615596
8 RAG2 NM_000536.3(RAG2): c.123C> G (p.Cys41Trp) single nucleotide variant Pathogenic rs121917895 GRCh38 Chromosome 11, 36594046: 36594046
9 RAG2 NM_000536.3(RAG2): c.854T> G (p.Met285Arg) single nucleotide variant Pathogenic rs121917896 GRCh37 Chromosome 11, 36614865: 36614865
10 RAG2 NM_000536.3(RAG2): c.854T> G (p.Met285Arg) single nucleotide variant Pathogenic rs121917896 GRCh38 Chromosome 11, 36593315: 36593315
11 RAG2 NM_000536.3(RAG2): c.283G> A (p.Gly95Arg) single nucleotide variant Pathogenic rs36001797 GRCh37 Chromosome 11, 36615436: 36615436
12 RAG2 NM_000536.3(RAG2): c.283G> A (p.Gly95Arg) single nucleotide variant Pathogenic rs36001797 GRCh38 Chromosome 11, 36593886: 36593886
13 RAG2 NM_000536.3(RAG2): c.115A> G (p.Arg39Gly) single nucleotide variant Pathogenic rs121917897 GRCh37 Chromosome 11, 36615604: 36615604
14 RAG2 NM_000536.3(RAG2): c.115A> G (p.Arg39Gly) single nucleotide variant Pathogenic rs121917897 GRCh38 Chromosome 11, 36594054: 36594054
15 RAG1 NM_000448.2(RAG1): c.1682G> A (p.Arg561His) single nucleotide variant Pathogenic rs104894284 GRCh37 Chromosome 11, 36596536: 36596536
16 RAG1 NM_000448.2(RAG1): c.1682G> A (p.Arg561His) single nucleotide variant Pathogenic rs104894284 GRCh38 Chromosome 11, 36574986: 36574986
17 RAG1 NM_000448.2(RAG1): c.1186C> T (p.Arg396Cys) single nucleotide variant Pathogenic rs104894289 GRCh37 Chromosome 11, 36596040: 36596040
18 RAG1 NM_000448.2(RAG1): c.1186C> T (p.Arg396Cys) single nucleotide variant Pathogenic rs104894289 GRCh38 Chromosome 11, 36574490: 36574490
19 RAG1 NM_000448.2(RAG1): c.2735A> G (p.Tyr912Cys) single nucleotide variant Pathogenic rs104894290 GRCh37 Chromosome 11, 36597589: 36597589
20 RAG1 NM_000448.2(RAG1): c.2735A> G (p.Tyr912Cys) single nucleotide variant Pathogenic rs104894290 GRCh38 Chromosome 11, 36576039: 36576039
21 RAG1 NM_000448.2(RAG1): c.1187G> A (p.Arg396His) single nucleotide variant Pathogenic rs104894291 GRCh37 Chromosome 11, 36596041: 36596041
22 RAG1 NM_000448.2(RAG1): c.1187G> A (p.Arg396His) single nucleotide variant Pathogenic rs104894291 GRCh38 Chromosome 11, 36574491: 36574491
23 RAG1 NM_000448.2(RAG1): c.1286A> G (p.Asp429Gly) single nucleotide variant Pathogenic rs104894292 GRCh37 Chromosome 11, 36596140: 36596140
24 RAG1 NM_000448.2(RAG1): c.1286A> G (p.Asp429Gly) single nucleotide variant Pathogenic rs104894292 GRCh38 Chromosome 11, 36574590: 36574590
25 RAG1 NM_000448.2(RAG1): c.1681C> T (p.Arg561Cys) single nucleotide variant Pathogenic rs104894285 GRCh37 Chromosome 11, 36596535: 36596535
26 RAG1 NM_000448.2(RAG1): c.1681C> T (p.Arg561Cys) single nucleotide variant Pathogenic rs104894285 GRCh38 Chromosome 11, 36574985: 36574985
27 RAG1 NM_000448.2(RAG1): c.2210G> A (p.Arg737His) single nucleotide variant Pathogenic rs104894286 GRCh37 Chromosome 11, 36597064: 36597064
28 RAG1 NM_000448.2(RAG1): c.2210G> A (p.Arg737His) single nucleotide variant Pathogenic rs104894286 GRCh38 Chromosome 11, 36575514: 36575514
29 RAG1 RAG1, 13-BP DEL, NT1723 deletion Pathogenic
30 RAG1 RAG1, 2-BP DEL, 368AA deletion Pathogenic
31 RAG1 RAG1, 1-BP DEL, 887A deletion Pathogenic
32 RAG1 RAG1, 1-BP DEL, 631T deletion Pathogenic
33 RAG1 NM_000448.2(RAG1): c.983G> A (p.Cys328Tyr) single nucleotide variant Pathogenic rs121918571 GRCh37 Chromosome 11, 36595837: 36595837
34 RAG1 NM_000448.2(RAG1): c.983G> A (p.Cys328Tyr) single nucleotide variant Pathogenic rs121918571 GRCh38 Chromosome 11, 36574287: 36574287
35 RAG1 NM_000448.2(RAG1): c.2904C> A (p.Asn968Lys) single nucleotide variant Likely pathogenic rs193922463 GRCh37 Chromosome 11, 36597758: 36597758
36 RAG1 NM_000448.2(RAG1): c.2904C> A (p.Asn968Lys) single nucleotide variant Likely pathogenic rs193922463 GRCh38 Chromosome 11, 36576208: 36576208
37 RAG2 NM_000536.3(RAG2): c.1247G> T (p.Trp416Leu) single nucleotide variant Likely pathogenic rs193922572 GRCh37 Chromosome 11, 36614472: 36614472
38 RAG2 NM_000536.3(RAG2): c.1247G> T (p.Trp416Leu) single nucleotide variant Likely pathogenic rs193922572 GRCh38 Chromosome 11, 36592922: 36592922
39 DCLRE1C NM_001033855.2(DCLRE1C): c.2001A> G (p.Leu667=) single nucleotide variant Conflicting interpretations of pathogenicity rs61749163 GRCh37 Chromosome 10, 14950485: 14950485
40 DCLRE1C NM_001033855.2(DCLRE1C): c.2001A> G (p.Leu667=) single nucleotide variant Conflicting interpretations of pathogenicity rs61749163 GRCh38 Chromosome 10, 14908486: 14908486
41 DCLRE1C NM_001033855.2(DCLRE1C): c.780+10C> T single nucleotide variant Benign rs35927251 GRCh37 Chromosome 10, 14974843: 14974843
42 DCLRE1C NM_001033855.2(DCLRE1C): c.780+10C> T single nucleotide variant Benign rs35927251 GRCh38 Chromosome 10, 14932844: 14932844
43 DCLRE1C NM_001033855.2(DCLRE1C): c.728A> G (p.His243Arg) single nucleotide variant Benign/Likely benign rs12768894 GRCh37 Chromosome 10, 14974905: 14974905
44 DCLRE1C NM_001033855.2(DCLRE1C): c.728A> G (p.His243Arg) single nucleotide variant Benign/Likely benign rs12768894 GRCh38 Chromosome 10, 14932906: 14932906
45 RAG1 NM_000448.2(RAG1): c.2459A> G (p.Lys820Arg) single nucleotide variant Benign rs2227973 GRCh38 Chromosome 11, 36575763: 36575763
46 RAG1 NM_000448.2(RAG1): c.2459A> G (p.Lys820Arg) single nucleotide variant Benign rs2227973 GRCh37 Chromosome 11, 36597313: 36597313
47 RAG1 NM_000448.2(RAG1): c.2880A> G (p.Ala960=) single nucleotide variant Benign/Likely benign rs1980131 GRCh38 Chromosome 11, 36576184: 36576184
48 RAG1 NM_000448.2(RAG1): c.2880A> G (p.Ala960=) single nucleotide variant Benign/Likely benign rs1980131 GRCh37 Chromosome 11, 36597734: 36597734
49 RAG2 NM_000536.3(RAG2): c.878A> G (p.Glu293Gly) single nucleotide variant Benign/Likely benign rs16929093 GRCh38 Chromosome 11, 36593291: 36593291
50 RAG2 NM_000536.3(RAG2): c.878A> G (p.Glu293Gly) single nucleotide variant Benign/Likely benign rs16929093 GRCh37 Chromosome 11, 36614841: 36614841

Cosmic variations for Malignant Histiocytosis:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM476 BRAF haematopoietic and lymphoid tissue,central nervous system,lymphoid neoplasm,malignant histiocytosis c.1799T>A p.V600E 7:140753336-140753336 4

Expression for Malignant Histiocytosis

Search GEO for disease gene expression data for Malignant Histiocytosis.

Pathways for Malignant Histiocytosis

Pathways related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.7 CSF1 CSF1R FOS IL1A LTA MYC
2
Show member pathways
13.63 CSF1 CSF1R FOS IL1A LTA LYZ
3
Show member pathways
13.35 CSF1R FOS IL1A LTA MYC PDGFB
4
Show member pathways
13.21 CSF1 CSF1R FOS IL1A LTA PDGFB
5
Show member pathways
13.09 CSF1 CSF1R FOS IL1A LTA PDGFB
6
Show member pathways
12.79 CSF1 CSF1R MYB MYC PDGFB
7
Show member pathways
12.5 FOS IL1A LTA PDGFB
8 12.47 CSF1 CSF1R FOS IL1A MYC PDGFB
9
Show member pathways
12.45 IL1A LTA MYC PDGFB
10
Show member pathways
12.43 CSF1 CSF1R FOS IL1A LTA MYC
11 12.4 DCLRE1C MYB RAG1 TNFRSF8
12 12.21 FOS LTA MYB MYC PDGFB
13
Show member pathways
11.98 FOS MYC PDGFB
14 11.94 FOS IL1A PDGFB
15
Show member pathways
11.93 FOS IL1A MYC PDGFB
16 11.85 FOS IL1A MYC
17 11.84 CSF1 CSF1R FOS IL1A
18 11.82 FOS IL1A MYC
19 11.79 CSF1 FOS LTA
20 11.68 CSF1 FOS IL1A
21 11.66 CSF1 CSF1R IL1A TFRC
22
Show member pathways
11.54 LTA MYB MYC
23
Show member pathways
11.4 CSF1 CSF1R FOS
24 11.35 CSF1 CSF1R PDGFB
25 11.25 CSF1R LYZ MYB MYC RAG2
26 11.2 DCLRE1C RAG1 RAG2
27 11.14 CSF1 FOS IL1A MYB

GO Terms for Malignant Histiocytosis

Cellular components related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CSF1 IL1A LTA LYZ PDGFB SERPINA3
2 CSF1-CSF1R complex GO:1990682 8.62 CSF1 CSF1R

Biological processes related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.89 CSF1 IL1A LTA PDGFB
2 positive regulation of gene expression GO:0010628 9.86 CSF1 IL1A MYC PDGFB
3 cell proliferation GO:0008283 9.85 CSF1 CSF1R IL1A MYC
4 cytokine-mediated signaling pathway GO:0019221 9.72 CSF1 CSF1R FOS IL1A MYC
5 DNA recombination GO:0006310 9.69 DCLRE1C RAG1 RAG2
6 hemopoiesis GO:0030097 9.65 CSF1 CSF1R PDGFB
7 B cell differentiation GO:0030183 9.63 DCLRE1C RAG1 RAG2
8 positive regulation of smooth muscle cell proliferation GO:0048661 9.61 MYB MYC PDGFB
9 positive regulation of mitotic nuclear division GO:0045840 9.58 IL1A PDGFB
10 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.58 FOS PDGFB
11 positive regulation of osteoclast differentiation GO:0045672 9.57 CSF1 FOS
12 positive regulation of smooth muscle cell migration GO:0014911 9.54 MYC PDGFB
13 macrophage differentiation GO:0030225 9.52 CSF1 CSF1R
14 positive regulation of DNA biosynthetic process GO:2000573 9.49 MYC PDGFB
15 osteoclast differentiation GO:0030316 9.43 CSF1 CSF1R TFRC
16 pre-B cell allelic exclusion GO:0002331 9.4 RAG1 RAG2
17 macrophage colony-stimulating factor signaling pathway GO:0038145 9.37 CSF1 CSF1R
18 positive regulation of glial cell proliferation GO:0060252 9.33 LTA MYB MYC
19 inflammatory response GO:0006954 9.17 CSF1 CSF1R FOS IL1A LYZ SERPINA3
20 V(D)J recombination GO:0033151 9.13 DCLRE1C RAG1 RAG2

Molecular functions related to Malignant Histiocytosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.47 CSF1 CSF1R DCLRE1C FOS IL1A LTA
2 protein homodimerization activity GO:0042803 9.35 CSF1 CSF1R PDGFB RAG1 TFRC

Sources for Malignant Histiocytosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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