MCID: MLG069
MIFTS: 46

Malignant Hypertension

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Genetic diseases, Nephrological diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Malignant Hypertension

MalaCards integrated aliases for Malignant Hypertension:

Name: Malignant Hypertension 12 15 17 70
Hypertension, Malignant 44
Hypertension Malignant 54

Classifications:



External Ids:

Disease Ontology 12 DOID:10824
MeSH 44 D006974
NCIt 50 C3118
SNOMED-CT 67 155301003
UMLS 70 C0020540

Summaries for Malignant Hypertension

Disease Ontology : 12 A hypertension that is characterized by rapid onset of extremely high blood pressure.

MalaCards based summary : Malignant Hypertension, also known as hypertension, malignant, is related to nephrosclerosis and proteinuria, chronic benign. An important gene associated with Malignant Hypertension is REN (Renin), and among its related pathways/superpathways are cGMP-PKG signaling pathway and MicroRNAs in cardiomyocyte hypertrophy. The drugs Clevidipine and Hormones have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and brain, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 73 A hypertensive emergency is high blood pressure with potentially life-threatening symptoms and signs... more...

Related Diseases for Malignant Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension
Hypertension Due to Gain-of-Function Mutations in the Mineralocorticoid Receptor

Diseases related to Malignant Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 363)
# Related Disease Score Top Affiliating Genes
1 nephrosclerosis 31.0 AGTR1 ADAMTS13 ACE
2 proteinuria, chronic benign 30.9 REN AGTR1 ACE
3 thrombotic microangiopathy 30.9 VWF THBD ADAMTS13
4 hemolytic uremic syndrome, atypical 1 30.8 VWF THBD CFHR2 CFH ADAMTS13
5 hypertensive retinopathy 30.6 VWF REN AGTR1 ADAMTS13 ACE
6 uremia 30.5 VWF REN ACE
7 purpura 30.4 VWF THBD ADAMTS13 ACE
8 hypertension, diastolic 30.4 REN ACE
9 hypertensive encephalopathy 30.4 REN EDN1 AGTR1 ADAMTS13 ACE
10 acute kidney failure 30.3 REN NPPA CFH ADAMTS13
11 cardiac tamponade 30.3 REN NPPB ACE
12 microvascular complications of diabetes 3 30.1 REN AGTR1 ACE
13 fibromuscular dysplasia 30.1 REN AGTR1 AGT ACE
14 anuria 30.1 REN AGTR1 AGT ADAMTS13 ACE
15 thrombotic thrombocytopenic purpura 30.1 VWF THBD CFH ADAMTS13
16 conn's syndrome 30.1 REN NPPA CHGA AGTR1 ACE
17 cardiogenic shock 30.0 NPPB ADM
18 hemolytic anemia 29.9 VWF THBD CFH ADAMTS13
19 nonarteritic anterior ischemic optic neuropathy 29.9 EDN1 AGTR1 AGT ACE
20 catastrophic antiphospholipid syndrome 29.9 CFH ADAMTS13
21 renal hypertension 29.9 REN NPPB EDN1 AGTR1 AGT ADM
22 microvascular complications of diabetes 5 29.9 AGTR1 AGT ACE
23 aortic aneurysm, familial abdominal, 1 29.8 REN AGTR1 ACE
24 hypertensive nephropathy 29.8 AGTR1 ACE
25 pheochromocytoma 29.8 REN NPPA EDN1 CHGA ADM ACE
26 cardiac arrest 29.8 REN NPPB ACE
27 antiphospholipid syndrome 29.8 VWF THBD CFH ADAMTS13
28 renal dysplasia 29.8 REN AGTR1 AGT ACE
29 vesicoureteral reflux 1 29.7 REN AGTR1 AGT ACE
30 renovascular hypertension 29.7 REN NPPB NPPA EDN1 AGTR1 ADM
31 renal hypodysplasia/aplasia 1 29.7 REN AGTR1 AGT ACE
32 disseminated intravascular coagulation 29.7 VWF THBD ADAMTS13
33 eclampsia 29.7 THBD REN EDN1 AGT ACE
34 iga glomerulonephritis 29.7 REN CFHR2 CFH AGTR1 AGT ACE
35 polycythemia 29.6 REN EDN1 ACE
36 focal segmental glomerulosclerosis 29.6 TRPC6 EDN1 AGTR1 AGT ACE
37 hemolytic-uremic syndrome 29.6 VWF THBD CFHR2 CFH ADAMTS13
38 pericardial effusion 29.5 REN NPPB NPPA ACE
39 thrombocytopenia 29.5 VWF THBD EDN1 CFH ADAMTS13
40 vascular disease 29.5 VWF THBD REN NPPB EDN1 AGT
41 nephrotic syndrome 29.5 TRPC6 REN NPPA AGT ACE
42 polycystic kidney disease 29.5 REN EDN1 AGTR1 AGT ACE
43 renal artery disease 29.4 REN NPPA AGTR1 AGT ACE
44 pulmonary edema 29.3 REN NPPB NPPA EDN1 AGTR1 ACE
45 end stage renal disease 29.0 TRPC6 THBD REN NPPB CFH AGTR1
46 pre-eclampsia 28.9 VWF THBD REN NPPA EDN1 AGTR1
47 hellp syndrome 28.8 VWF THBD EDN1 CFH ADM ADAMTS13
48 kidney disease 28.7 TRPC6 THBD REN NPPB NPPA EDN1
49 deficiency anemia 28.4 NPPA CYP1A1 CFHR2 CFH ADAMTS13 ACE
50 cerebrovascular disease 28.4 VWF THBD REN NPPB NPPA AGTR1

Graphical network of the top 20 diseases related to Malignant Hypertension:



Diseases related to Malignant Hypertension

Symptoms & Phenotypes for Malignant Hypertension

MGI Mouse Phenotypes related to Malignant Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 ACE ADM AGT AGTR1 CFH CHGA
2 homeostasis/metabolism MP:0005376 10.18 ACE ADAMTS13 ADM AGT AGTR1 CFH
3 hematopoietic system MP:0005397 10.14 ACE ADAMTS13 ADM AGTR1 CFH CYP1A1
4 mortality/aging MP:0010768 10.07 ACE ADAMTS13 ADM AGT AGTR1 CFH
5 immune system MP:0005387 10.06 ACE ADAMTS13 ADM AGT AGTR1 CFH
6 muscle MP:0005369 9.76 ADM AGT CFH CHGA EDN1 NPPA
7 nervous system MP:0003631 9.7 ACE AGT AGTR1 CFH CHGA EDN1
8 renal/urinary system MP:0005367 9.32 ACE ADM AGT AGTR1 CFH CHGA

Drugs & Therapeutics for Malignant Hypertension

Drugs for Malignant Hypertension (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clevidipine Approved, Investigational Phase 3 167221-71-8
2 Hormones Phase 3
3 Antihypertensive Agents Phase 3
4 Tin Fluorides Phase 3
5 calcium channel blockers Phase 3
6 Calcium, Dietary Phase 3
7
Calcium Nutraceutical Phase 3 7440-70-2 271

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Single Blind, Positive Parallel Controlled, Multicenter, Phase III Clinical Trial of Clevidipine Butyrate Injection in the Treatment of Hypertensive Emergencies Recruiting NCT04670809 Phase 3 Clevidipine Butyrate Injection;Ncardipine Hydrochloride Injection
2 Single Incision Laparoscopy Completed NCT00616616
3 Telemedical Versus Conventional Emergency Care of Hypertensive Emergencies and Urgencies Completed NCT02924805
4 A New Breath for Malignant Hypertension: Implementation of the HAMA Cohort Recruiting NCT03755726
5 The Effect of Using Ambu Aura-i Laryngeal Mask Airway Versus Endotracheal Tube on Emergence Hypertension in Supratentorial Cranial Surgery: A Randomized Controlled Study Enrolling by invitation NCT04582227

Search NIH Clinical Center for Malignant Hypertension

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Captopril
Diazoxide
Enalapril
Enalapril Maleate
Enalaprilat
Fenoldopam
Fenoldopam Mesylate
Hydralazine
Hydralazine Hydrochloride
Labetalol
Labetalol hydrochloride
Mecamylamine
Mecamylamine hydrochloride
Minoxidil
nebivolol
Phenoxybenzamine
Phenoxybenzamine Hydrochloride
Phentolamine
Phentolamine Mesylate
Sodium Nitroprusside
trimethaphan camsylate

Cochrane evidence based reviews: hypertension, malignant

Genetic Tests for Malignant Hypertension

Anatomical Context for Malignant Hypertension

MalaCards organs/tissues related to Malignant Hypertension:

40
Kidney, Heart, Brain, Eye, Liver, Endothelial, Retina

Publications for Malignant Hypertension

Articles related to Malignant Hypertension:

(show top 50) (show all 2005)
# Title Authors PMID Year
1
Association between thrombotic microangiopathy and reduced ADAMTS13 activity in malignant hypertension. 54 61
18332284 2008
2
The renin-angiotensin system in malignant hypertension revisited: plasma renin activity, microangiopathic hemolysis, and renal failure in malignant hypertension. 61 54
17679041 2007
3
Aliskiren, the first renin inhibitor for treating hypertension: reactive renin secretion may limit its effectiveness. 61 54
17485026 2007
4
Angiotensin-converting enzyme i/d polymorphism in patients with malignant hypertension. 61 54
15655381 2005
5
The role of the renin-angiotensin system in malignant vascular injury affecting the systemic and cerebral circulations. 61 54
14769441 2004
6
Recovery from renal failure in malignant hypertension associated with primary aldosteronism: effect of an ACE inhibitor. 61 54
11861963 2002
7
Angiotensin-converting enzyme gene I/D polymorphism in malignant hypertension. 61 54
10855732 2000
8
Plasma adrenomedullin and natriuretic peptides in patients with essential or malignant hypertension. 61 54
10221353 1999
9
The importance of the renin-angiotensin system in cardiovascular disease. 54 61
9655650 1998
10
The Tsukuba hypertensive mouse (transgenic mouse carrying human genes for both renin and angiotensinogen) as a model of human malignant hypertension: development of lesions and morphometric analysis. 61 54
9504863 1998
11
Nephrosclerosis and hypertension. 54 61
9356598 1997
12
Malignant hypertension in a patient with primary aldosteronism with elevated active renin concentration. 61 54
9372330 1997
13
Antihypertensive therapy reduces increased plasma levels of adrenomedullin and brain natriuretic peptide concomitant with regression of left ventricular hypertrophy in a patient with malignant hypertension. 61 54
10968202 1996
14
Hyperrenin-hyperaldosterone-dependent malignant hypertension in polyarteritis nodosa. 61 54
7903825 1993
15
Blood pressure, angiotensin-converting enzyme (ACE) inhibitors, and the kidney. 61 54
1580276 1992
16
Angiotensin converting enzyme inhibitors in cardiovascular and renal disease in Africans: a review. 61 54
1908620 1991
17
Alarming trends in the frequency of malignant hypertension among admissions with a known cannabis use disorder. 61
33665351 2021
18
A single-cell survey of the human glomerulonephritis. 61
33754492 2021
19
Monogenic Lupus with IgA Nephropathy Caused by Spondyloenchondrodysplasia with Immune Dysregulation. 61
33712926 2021
20
Association between long-term pulse pressure trajectories and risk of end-stage renal diseases in incident malignant hypertensive nephropathy: a cohort study. 61
32740292 2021
21
Hyperhomocysteinemia: a trigger for complement-mediated TMA? 61
31401947 2021
22
Retinal Arteriolar Occlusions and Exudative Retinal Detachments in Malignant Hypertension: More Than Meets the Eye. 61
32840289 2021
23
Scleroderma renal crisis. 61
33548376 2021
24
Eculizumab use in a tertiary care nephrology center: data from the Vienna TMA cohort. 61
33599971 2021
25
Bilateral detachment of the neurosensory retina in an apparently asymptomatic woman. 61
33560051 2021
26
Complement in Secondary Thrombotic Microangiopathy. 61
33102952 2021
27
Concurrent analogous organ damage in the brain, eyes, and kidneys in malignant hypertension: reversible encephalopathy, serous retinal detachment, and proteinuria. 61
32719463 2021
28
Post-traumatic thrombotic microangiopathy: What trauma surgeons need to know? 61
33518399 2021
29
Subendocardial stress in pre-eclampsia. 61
32501623 2021
30
Malignant hypertension and multiorgan damage: mechanisms to be elucidated and countermeasures. 61
33028988 2021
31
Olfactory neurocytoma as a unique cause of chronic SIADH. 61
33461989 2021
32
Malignant hypertension and thrombotic microangiopathy: complement as a usual suspect. 61
33301026 2020
33
[HYPERTENSION AS A CAUSE OF RENAL DISEASE - FACT OR FICTION?] 61
33369304 2020
34
Association between thrombotic microangiopathy and activated alternative complement pathway in malignant nephrosclerosis. 61
33367879 2020
35
Acute Kidney Injury Relevant to Tubulointerstitial Nephritis with Late-Onset Uveitis Superimposed by Thrombotic Microangiopathy: A Case Report and Review of the Literature. 61
33313062 2020
36
The pharmacological management of malignant hypertension. 61
32649635 2020
37
Malignant Hypertension and Osteoporotic Fractures in a 15-year-old Boy. 61
33004665 2020
38
Subretinal Deposits in Pre-eclampsia and Malignant Hypertension: Implications for Age-Related Macular Degeneration. 61
33130003 2020
39
Scleroderma-associated thrombotic microangiopathy in overlap syndrome of systemic sclerosis and systemic lupus erythematosus: A case report and literature review. 61
33031308 2020
40
Catecholamine-induced cerebral vasospasm and multifocal infarctions in pheochromocytoma. 61
32820130 2020
41
Clinical utility of ultra-rapid whole-genome sequencing in an infant with atypical presentation of WT1-associated nephrotic syndrome type 4. 61
32843431 2020
42
2020 Vision? A case of malignant hypertension. 61
32843463 2020
43
Malignant Hypertension Without End-Organ Damage Secondary to Stressful Condition in a Female. 61
33005527 2020
44
Pharmacological management of malignant hypertension. 61
32100590 2020
45
Rapid Improvement in Gemcitabine-associated Thrombotic Microangiopathy After a Single Dose of Eculizumab: Case Report and Review of the Literature. 61
32620643 2020
46
A rare case of malignant hypertension with splenic rupture and thrombotic microangiopathy: A case report. 61
32664062 2020
47
Rapidly progressive glomerulonephritis and acute kidney injury associated with cocaine use - Case report. 61
32573647 2020
48
Renal disorders in rheumatologic diseases: the spectrum is changing (Part 1: connective tissue diseases). 61
32529559 2020
49
Clinical value of multiorgan damage in hypertensive crises: A prospective follow-up study. 61
32271999 2020
50
Efficacy of trazodone for treating paroxysmal sympathetic hyperactivity presenting after left temporal subcortical hemorrhage. 61
32494561 2020

Variations for Malignant Hypertension

Expression for Malignant Hypertension

Search GEO for disease gene expression data for Malignant Hypertension.

Pathways for Malignant Hypertension

GO Terms for Malignant Hypertension

Cellular components related to Malignant Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 VWF REN NPPB NPPA EDN1 CHGA
2 extracellular space GO:0005615 9.4 VWF THBD REN NPPB NPPA EDN1
3 cation channel complex GO:0034703 9.26 TRPC6 TRPC3
4 Weibel-Palade body GO:0033093 9.16 VWF EDN1

Biological processes related to Malignant Hypertension according to GeneCards Suite gene sharing:

(show all 46)
# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.88 TRPC6 CYP1A1 AGT ADM
2 negative regulation of cell growth GO:0030308 9.87 NPPB NPPA AGT
3 response to hypoxia GO:0001666 9.87 NPPA EDN1 CYP1A1 ADM
4 kidney development GO:0001822 9.84 REN AGTR1 AGT ACE
5 response to organic substance GO:0010033 9.82 REN CYP1A1 ADM
6 platelet activation GO:0030168 9.8 VWF TRPC6 TRPC3 ADAMTS13
7 response to wounding GO:0009611 9.79 VWF CYP1A1 ADM
8 hemostasis GO:0007599 9.77 VWF THBD ADAMTS13
9 response to lipopolysaccharide GO:0032496 9.77 THBD REN EDN1 CYP1A1 ADM
10 female pregnancy GO:0007565 9.73 THBD NPPA AGT ADM
11 positive regulation of cytosolic calcium ion concentration GO:0007204 9.72 TRPC6 EDN1 AGTR1 AGT ADM
12 cGMP-mediated signaling GO:0019934 9.7 NPPB NPPA
13 regulation of the force of heart contraction GO:0002026 9.7 CHGA ADM
14 positive regulation of blood vessel diameter GO:0097755 9.69 AGT ADM
15 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.69 AGTR1 AGT
16 vasoconstriction GO:0042310 9.68 EDN1 AGT
17 response to muscle stretch GO:0035994 9.68 NPPA EDN1
18 low-density lipoprotein particle remodeling GO:0034374 9.68 AGTR1 AGT
19 cell growth involved in cardiac muscle cell development GO:0061049 9.68 NPPA AGT
20 peptide catabolic process GO:0043171 9.67 ADAMTS13 ACE
21 positive regulation of cellular protein metabolic process GO:0032270 9.67 AGTR1 AGT
22 amyloid-beta metabolic process GO:0050435 9.67 REN ACE
23 positive regulation of urine volume GO:0035810 9.66 NPPB EDN1
24 negative regulation of blood coagulation GO:0030195 9.66 THBD EDN1
25 negative regulation of systemic arterial blood pressure GO:0003085 9.65 NPPB NPPA
26 manganese ion transport GO:0006828 9.65 TRPC6 TRPC3
27 angiotensin maturation GO:0002003 9.65 REN ACE
28 regulation of blood vessel diameter GO:0097746 9.65 NPPB AGTR1 ACE
29 artery smooth muscle contraction GO:0014824 9.64 EDN1 AGT
30 cGMP biosynthetic process GO:0006182 9.63 NPPB NPPA
31 positive regulation of cardiac muscle contraction GO:0060452 9.63 NPPA CHGA
32 positive regulation of heart rate GO:0010460 9.63 NPPA EDN1 ADM
33 receptor guanylyl cyclase signaling pathway GO:0007168 9.62 NPPB NPPA
34 positive regulation of cholesterol esterification GO:0010873 9.62 AGTR1 AGT
35 body fluid secretion GO:0007589 9.61 NPPB EDN1
36 positive regulation of NAD(P)H oxidase activity GO:0033864 9.6 AGTR1 AGT
37 maternal process involved in parturition GO:0060137 9.58 EDN1 CYP1A1
38 positive regulation of renal sodium excretion GO:0035815 9.58 NPPB EDN1 AGT
39 regulation of renal sodium excretion GO:0035813 9.56 AGTR1 AGT
40 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.55 AGTR1 AGT
41 regulation of renal output by angiotensin GO:0002019 9.52 AGT ACE
42 regulation of blood volume by renin-angiotensin GO:0002016 9.51 REN AGT
43 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.43 AGTR1 AGT ACE
44 renin-angiotensin regulation of aldosterone production GO:0002018 9.33 REN AGTR1 AGT
45 regulation of vasoconstriction GO:0019229 9.26 EDN1 AGTR1 AGT ACE
46 regulation of blood pressure GO:0008217 9.17 REN NPPB NPPA EDN1 CHGA AGT

Molecular functions related to Malignant Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 REN NPPB NPPA EDN1 ADM
2 endopeptidase activity GO:0004175 9.54 REN ADAMTS13 ACE
3 inositol 1,4,5 trisphosphate binding GO:0070679 9.4 TRPC6 TRPC3
4 store-operated calcium channel activity GO:0015279 9.32 TRPC6 TRPC3
5 hormone receptor binding GO:0051427 9.26 NPPB NPPA
6 hormone activity GO:0005179 9.02 NPPB NPPA EDN1 AGT ADM
7 bradykinin receptor binding GO:0031711 8.96 AGTR1 ACE

Sources for Malignant Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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