MCID: MLG004
MIFTS: 23

Malignant Hypertensive Renal Disease

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Malignant Hypertensive Renal Disease

MalaCards integrated aliases for Malignant Hypertensive Renal Disease:

Name: Malignant Hypertensive Renal Disease 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:10177
SNOMED-CT 69 65443008
ICD10 34 I12 I12.0 I12.9
UMLS 74 C0155593

Summaries for Malignant Hypertensive Renal Disease

MalaCards based summary : Malignant Hypertensive Renal Disease is related to renal fibrosis and glucose metabolism disease. An important gene associated with Malignant Hypertensive Renal Disease is REN (Renin), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and HIF-1 signaling pathway. Affiliated tissues include kidney, heart and liver, and related phenotype is renal/urinary system.

Related Diseases for Malignant Hypertensive Renal Disease

Diseases in the Benign Hypertensive Renal Disease family:

Malignant Hypertensive Renal Disease

Diseases related to Malignant Hypertensive Renal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 renal fibrosis 10.0 REN SERPINE1
2 glucose metabolism disease 10.0 REN SERPINE1
3 acquired metabolic disease 10.0 REN SERPINE1
4 cerebrovascular disease 9.9 REN SERPINE1
5 idiopathic interstitial pneumonia 9.9 EDN1 SERPINE1
6 renovascular hypertension 9.9 EDN1 REN
7 eclampsia 9.9 EDN1 REN
8 perinephritis 9.9 EDN1 REN
9 malignant hypertension 9.8 EDN1 REN
10 renal tuberculosis 9.8 EDN1 REN
11 hepatorenal syndrome 9.8 EDN1 REN
12 renal hypertension 9.8 EDN1 REN
13 apnea, obstructive sleep 9.8 EDN1 REN
14 hellp syndrome 9.8 EDN1 SERPINE1
15 idiopathic hypercalciuria 9.8 EDN1 REN
16 coronary artery anomaly 9.8 EDN1 SERPINE1
17 obstructive jaundice 9.8 EDN1 REN
18 oligohydramnios 9.8 EDN1 REN
19 pulmonary edema 9.8 EDN1 REN
20 aging 9.8 EDN1 SERPINE1
21 sleep apnea 9.8 EDN1 REN
22 arteriosclerosis 9.8 EDN1 SERPINE1
23 urinary system disease 9.8 EDN1 REN
24 congestive heart failure 9.8 EDN1 REN
25 acute myocardial infarction 9.8 EDN1 SERPINE1
26 autosomal dominant polycystic kidney disease 9.7 EDN1 REN
27 chronic kidney failure 9.7 EDN1 REN
28 tetralogy of fallot 9.7 EDN1 REN
29 liver cirrhosis 9.6 EDN1 REN
30 stroke, ischemic 9.6 REN SERPINE1
31 malignant renovascular hypertension 9.6 EDN1 REN SERPINE1
32 malignant secondary hypertension 9.6 EDN1 REN SERPINE1
33 hepatic vascular disease 9.6 EDN1 REN SERPINE1
34 vascular disease 9.6 EDN1 REN SERPINE1
35 pulmonary hypertension 9.6 EDN1 REN
36 arteries, anomalies of 9.6 EDN1 REN SERPINE1
37 pre-eclampsia 9.6 EDN1 REN SERPINE1
38 hypertension, essential 9.5 EDN1 REN SERPINE1
39 kidney disease 9.5 EDN1 REN SERPINE1
40 heart disease 9.5 EDN1 REN SERPINE1
41 myocardial infarction 9.5 EDN1 REN SERPINE1
42 diabetes mellitus 9.5 EDN1 REN SERPINE1

Graphical network of the top 20 diseases related to Malignant Hypertensive Renal Disease:



Diseases related to Malignant Hypertensive Renal Disease

Symptoms & Phenotypes for Malignant Hypertensive Renal Disease

MGI Mouse Phenotypes related to Malignant Hypertensive Renal Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.8 EDN1 REN SERPINE1

Drugs & Therapeutics for Malignant Hypertensive Renal Disease

Search Clinical Trials , NIH Clinical Center for Malignant Hypertensive Renal Disease

Genetic Tests for Malignant Hypertensive Renal Disease

Anatomical Context for Malignant Hypertensive Renal Disease

MalaCards organs/tissues related to Malignant Hypertensive Renal Disease:

42
Kidney, Heart, Liver

Publications for Malignant Hypertensive Renal Disease

Variations for Malignant Hypertensive Renal Disease

Expression for Malignant Hypertensive Renal Disease

Search GEO for disease gene expression data for Malignant Hypertensive Renal Disease.

Pathways for Malignant Hypertensive Renal Disease

GO Terms for Malignant Hypertensive Renal Disease

Cellular components related to Malignant Hypertensive Renal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 EDN1 REN SERPINE1

Biological processes related to Malignant Hypertensive Renal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.32 EDN1 REN
2 response to lipopolysaccharide GO:0032496 9.26 EDN1 REN
3 cellular response to drug GO:0035690 9.16 EDN1 REN
4 regulation of blood pressure GO:0008217 8.96 EDN1 REN
5 negative regulation of blood coagulation GO:0030195 8.62 EDN1 SERPINE1

Molecular functions related to Malignant Hypertensive Renal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.8 EDN1 REN SERPINE1

Sources for Malignant Hypertensive Renal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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