MCID: MLG004
MIFTS: 23

Malignant Hypertensive Renal Disease

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Malignant Hypertensive Renal Disease

MalaCards integrated aliases for Malignant Hypertensive Renal Disease:

Name: Malignant Hypertensive Renal Disease 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10177
SNOMED-CT 68 65443008
ICD10 33 I12 I12.0 I12.9
UMLS 73 C0155593

Summaries for Malignant Hypertensive Renal Disease

MalaCards based summary : Malignant Hypertensive Renal Disease is related to renovascular hypertension and perinephritis. An important gene associated with Malignant Hypertensive Renal Disease is REN (Renin), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and HIF-1 signaling pathway. Affiliated tissues include kidney, liver and heart, and related phenotype is renal/urinary system.

Related Diseases for Malignant Hypertensive Renal Disease

Diseases in the Benign Hypertensive Renal Disease family:

Malignant Hypertensive Renal Disease

Diseases related to Malignant Hypertensive Renal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 renovascular hypertension 10.0 EDN1 REN
2 perinephritis 10.0 REN EDN1
3 eclampsia 10.0 EDN1 REN
4 malignant hypertension 10.0 REN EDN1
5 renal tuberculosis 10.0 EDN1 REN
6 hepatorenal syndrome 10.0 EDN1 REN
7 renal hypertension 10.0 EDN1 REN
8 apnea, obstructive sleep 10.0 EDN1 REN
9 idiopathic hypercalciuria 10.0 EDN1 REN
10 obstructive jaundice 10.0 EDN1 REN
11 oligohydramnios 10.0 EDN1 REN
12 pulmonary edema 10.0 EDN1 REN
13 sleep apnea 10.0 EDN1 REN
14 urinary system disease 10.0 EDN1 REN
15 congestive heart failure 10.0 EDN1 REN
16 autosomal dominant polycystic kidney disease 9.9 EDN1 REN
17 idiopathic interstitial pneumonia 9.9 EDN1 SERPINE1
18 chronic kidney failure 9.9 EDN1 REN
19 hellp syndrome 9.9 EDN1 SERPINE1
20 coronary artery anomaly 9.9 EDN1 SERPINE1
21 tetralogy of fallot 9.9 EDN1 REN
22 aging 9.9 EDN1 SERPINE1
23 arteriosclerosis 9.9 EDN1 SERPINE1
24 renal fibrosis 9.9 REN SERPINE1
25 glucose metabolism disease 9.9 REN SERPINE1
26 acquired metabolic disease 9.9 REN SERPINE1
27 liver cirrhosis 9.9 EDN1 REN
28 acute myocardial infarction 9.9 EDN1 SERPINE1
29 coronary heart disease 1 9.8 EDN1 SERPINE1
30 cerebrovascular disease 9.8 REN SERPINE1
31 pulmonary hypertension 9.8 EDN1 REN
32 malignant renovascular hypertension 9.7 SERPINE1 REN EDN1
33 malignant secondary hypertension 9.7 SERPINE1 REN EDN1
34 hepatic vascular disease 9.7 SERPINE1 REN EDN1
35 vascular disease 9.7 SERPINE1 REN EDN1
36 arteries, anomalies of 9.7 SERPINE1 REN EDN1
37 hypertension, essential 9.7 SERPINE1 REN EDN1
38 pre-eclampsia 9.7 SERPINE1 REN EDN1
39 kidney disease 9.7 EDN1 REN SERPINE1
40 heart disease 9.7 EDN1 REN SERPINE1
41 myocardial infarction 9.7 EDN1 REN SERPINE1
42 diabetes mellitus 9.7 EDN1 REN SERPINE1
43 stroke, ischemic 9.6 REN SERPINE1

Graphical network of the top 20 diseases related to Malignant Hypertensive Renal Disease:



Diseases related to Malignant Hypertensive Renal Disease

Symptoms & Phenotypes for Malignant Hypertensive Renal Disease

MGI Mouse Phenotypes related to Malignant Hypertensive Renal Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.8 EDN1 REN SERPINE1

Drugs & Therapeutics for Malignant Hypertensive Renal Disease

Search Clinical Trials , NIH Clinical Center for Malignant Hypertensive Renal Disease

Genetic Tests for Malignant Hypertensive Renal Disease

Anatomical Context for Malignant Hypertensive Renal Disease

MalaCards organs/tissues related to Malignant Hypertensive Renal Disease:

41
Kidney, Liver, Heart

Publications for Malignant Hypertensive Renal Disease

Variations for Malignant Hypertensive Renal Disease

Expression for Malignant Hypertensive Renal Disease

Search GEO for disease gene expression data for Malignant Hypertensive Renal Disease.

Pathways for Malignant Hypertensive Renal Disease

GO Terms for Malignant Hypertensive Renal Disease

Cellular components related to Malignant Hypertensive Renal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 EDN1 REN SERPINE1

Biological processes related to Malignant Hypertensive Renal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.32 EDN1 REN
2 response to lipopolysaccharide GO:0032496 9.26 EDN1 REN
3 cellular response to drug GO:0035690 9.16 EDN1 REN
4 regulation of blood pressure GO:0008217 8.96 EDN1 REN
5 negative regulation of blood coagulation GO:0030195 8.62 EDN1 SERPINE1

Molecular functions related to Malignant Hypertensive Renal Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.8 EDN1 REN SERPINE1

Sources for Malignant Hypertensive Renal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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