MCID: MLG167
MIFTS: 23

Malignant Inflammatory Fibrous Histiocytoma

Categories: Bone diseases, Cancer diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Malignant Inflammatory Fibrous Histiocytoma

MalaCards integrated aliases for Malignant Inflammatory Fibrous Histiocytoma:

Name: Malignant Inflammatory Fibrous Histiocytoma 12 15
Inflammatory Mfh 12
Xanthosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6192
NCIt 49 C6497
UMLS 71 C1334180

Summaries for Malignant Inflammatory Fibrous Histiocytoma

MalaCards based summary : Malignant Inflammatory Fibrous Histiocytoma, also known as inflammatory mfh, is related to fibrous histiocytoma and benign giant cell tumor. An important gene associated with Malignant Inflammatory Fibrous Histiocytoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Integrated Cancer Pathway and DNA damage_ATM/ATR regulation of G1/S checkpoint. Affiliated tissues include bone.

Related Diseases for Malignant Inflammatory Fibrous Histiocytoma

Diseases in the Fibrous Histiocytoma family:

Malignant Fibrous Histiocytoma Malignant Inflammatory Fibrous Histiocytoma

Diseases related to Malignant Inflammatory Fibrous Histiocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 fibrous histiocytoma 30.6 SERPINA3 CD68
2 benign giant cell tumor 30.3 SERPINA3 CD68
3 malignant fibrous histiocytoma 29.3 SERPINA3 MDM2 CDK4 CD68
4 verruciform xanthoma of skin 10.3 SERPINA3 CD68
5 proliferative fasciitis 10.3 SERPINA3 CD68
6 congenital epulis 10.3 SERPINA3 CD68
7 epulis 10.3 SERPINA3 CD68
8 xanthogranulomatous pyelonephritis 10.3 SERPINA3 CD68
9 reticulohistiocytic granuloma 10.3 SERPINA3 CD68
10 sarcomatoid squamous cell skin carcinoma 10.3 SERPINA3 CD68
11 malignant granular cell myoblastoma 10.3 SERPINA3 CD68
12 liver sarcoma 10.3 SERPINA3 CD68
13 multicentric reticulohistiocytosis 10.3 SERPINA3 CD68
14 xanthogranulomatous cholecystitis 10.3 SERPINA3 CD68
15 interdigitating dendritic cell sarcoma 10.3 SERPINA3 CD68
16 histiocytic and dendritic cell cancer 10.3 SERPINA3 CD68
17 non-langerhans-cell histiocytosis 10.3 SERPINA3 CD68
18 tenosynovial giant cell tumor 10.3 SERPINA3 CD68
19 malignant spindle cell melanoma 10.3 SERPINA3 CD68
20 giant cell reparative granuloma 10.3 SERPINA3 CD68
21 adult xanthogranuloma 10.3 SERPINA3 CD68
22 erdheim-chester disease 10.3 SERPINA3 CD68
23 fibrosarcoma of bone 10.2 SERPINA3 CD68
24 central nervous system vasculitis 10.2 SERPINA3 CD68
25 pseudosarcomatous fibromatosis 10.2 SERPINA3 CD68
26 cutaneous fibrous histiocytoma 10.2 SERPINA3 CD68
27 pigmented villonodular synovitis 10.2 SERPINA3 CD68
28 bone giant cell tumor 10.2 SERPINA3 CD68
29 histiocytosis-lymphadenopathy plus syndrome 10.2 SERPINA3 CD68
30 granular cell tumor 10.2 SERPINA3 CD68
31 malignant mesenchymoma 10.2 SERPINA3 MDM2
32 aphasia 10.2
33 hemiplegia 10.2
34 malignant fibrous histiocytoma of bone 10.2
35 mesenchymal cell neoplasm 10.2 SERPINA3 CD68
36 cardiovascular cancer 10.1 SERPINA3 CD68
37 heart cancer 10.1 SERPINA3 MDM2
38 conventional fibrosarcoma 10.1 MDM2 CD68
39 vascular cancer 10.1 SERPINA3 CD68
40 reticulosarcoma 10.1 SERPINA3 CD68
41 ossifying fibroma 10.1 SERPINA3 MDM2
42 omenn syndrome 10.1
43 spindle cell sarcoma 10.1 SERPINA3 MDM2
44 hemangiopericytoma, malignant 10.0 SERPINA3 MDM2
45 follicular dendritic cell sarcoma 9.9 MDM2 CD68
46 hypersensitivity reaction type iv disease 9.9 SERPINA3 CD68
47 giant cell glioblastoma 9.8 SERPINA3 MDM2
48 ring chromosome 7 9.8 MDM2 CDK4
49 ring chromosome 9.8 MDM2 CDK4
50 mediastinum liposarcoma 9.8 MDM2 CDK4

Graphical network of the top 20 diseases related to Malignant Inflammatory Fibrous Histiocytoma:



Diseases related to Malignant Inflammatory Fibrous Histiocytoma

Symptoms & Phenotypes for Malignant Inflammatory Fibrous Histiocytoma

Drugs & Therapeutics for Malignant Inflammatory Fibrous Histiocytoma

Search Clinical Trials , NIH Clinical Center for Malignant Inflammatory Fibrous Histiocytoma

Genetic Tests for Malignant Inflammatory Fibrous Histiocytoma

Anatomical Context for Malignant Inflammatory Fibrous Histiocytoma

MalaCards organs/tissues related to Malignant Inflammatory Fibrous Histiocytoma:

40
Bone

Publications for Malignant Inflammatory Fibrous Histiocytoma

Articles related to Malignant Inflammatory Fibrous Histiocytoma:

(show all 12)
# Title Authors PMID Year
1
[Selective arterial embolization for the treatment of thoracolumbar spinal tumor]. 61
11829936 1999
2
[Juvenile xanthogranuloma of the auricle]. 61
9035680 1996
3
Juvenile xanthogranuloma of the penis. 61
8326577 1993
4
Xanthomatous change in tumours of glial origin. 61
2177036 1990
5
Inflammatory malignant fibrous histiocytoma of the spermatic cord. 61
2845620 1988
6
Monstrocellular heavily lipidized malignant glioma. 61
3515829 1986
7
Malignant inflammatory fibrous histiocytoma of bone and acute lymphoblastic leukaemia. 61
2991874 1985
8
[Intracerebral fibrous xanthosarcoma--report of a case]. 61
7177324 1982
9
[Intra-abdominal xanthosarcoma and xanthogranuloma: report of 2 cases (author's transl)]. 61
7238217 1980
10
Malignant fibrous histiocytoma (malignant fibrous xanthoma: xanthosarcoma) of bone. 61
209886 1978
11
Retroperitoneal xanthogranuloma and xanthosarcoma (malignant fibrous xanthoma). 61
4347188 1973
12
XANTHOSARCOMA OF THUMB: A CENTRAL BENIGN GIANT-CELL TUMOR OF THE PROXIMAL PHALANX OF THE THUMB. 61
17865243 1925

Variations for Malignant Inflammatory Fibrous Histiocytoma

Expression for Malignant Inflammatory Fibrous Histiocytoma

Search GEO for disease gene expression data for Malignant Inflammatory Fibrous Histiocytoma.

Pathways for Malignant Inflammatory Fibrous Histiocytoma

Pathways related to Malignant Inflammatory Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 MDM2 CDK4
2 10.6 MDM2 CDK4
3 10.13 MDM2 CDK4

GO Terms for Malignant Inflammatory Fibrous Histiocytoma

Biological processes related to Malignant Inflammatory Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lens development in camera-type eye GO:0002088 9.26 FRS2 CDK4
2 positive regulation of cell cycle GO:0045787 9.16 MDM2 CDK4
3 ventricular septum development GO:0003281 8.96 MDM2 FRS2
4 negative regulation of cell cycle arrest GO:0071157 8.62 MDM2 CDK4

Sources for Malignant Inflammatory Fibrous Histiocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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