MCID: MLG070
MIFTS: 23

Malignant Iris Melanoma

Categories: Cancer diseases, Neuronal diseases, Skin diseases

Aliases & Classifications for Malignant Iris Melanoma

MalaCards integrated aliases for Malignant Iris Melanoma:

Name: Malignant Iris Melanoma 12 15
Malignant Melanoma of Iris 12
Melanoma of the Iris 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6994
NCIt 50 C9088
SNOMED-CT 67 255012009
UMLS 70 C0346373

Summaries for Malignant Iris Melanoma

MalaCards based summary : Malignant Iris Melanoma, also known as malignant melanoma of iris, is related to neurofibroma and melanoma, uveal. An important gene associated with Malignant Iris Melanoma is S100A1 (S100 Calcium Binding Protein A1), and among its related pathways/superpathways is Ca, cAMP and Lipid Signaling. Affiliated tissues include endothelial.

Related Diseases for Malignant Iris Melanoma

Diseases related to Malignant Iris Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 neurofibroma 30.0 S100B S100A1
2 melanoma, uveal 11.3
3 iris spindle cell melanoma 11.2
4 leiomyoma 10.2
5 amelanotic melanoma 10.2
6 sarcoidosis 1 10.1
7 malignant spindle cell melanoma 10.1
8 cataract 10.1
9 neurofibromatosis 10.1
10 intraneural perineurioma 10.1 S100B S100A1
11 perineurioma 10.1 S100B S100A1
12 chordoid meningioma 10.1 S100B S100A1
13 epidermoid cysts 10.1 S100B S100A1
14 ossifying fibromyxoid tumor 10.1 S100B S100A1
15 polymorphous low-grade adenocarcinoma 10.1 S100B S100A1
16 spiradenoma 10.1 S100B S100A1
17 spindle cell rhabdomyosarcoma 10.1 S100B S100A1
18 juvenile xanthogranuloma 10.1 S100B S100A1
19 syringoma 10.1 S100B S100A1
20 cutaneous fibrous histiocytoma 10.1 S100B S100A1
21 granular cell tumor 10.1 S100B S100A1
22 myoepithelioma 10.1 S100B S100A1
23 melanoma in congenital melanocytic nevus 10.0 S100B S100A1
24 neurilemmoma 10.0 S100B S100A1
25 dedifferentiated liposarcoma 10.0 S100B S100A1
26 pleomorphic adenoma 10.0 S100B S100A1
27 dowling-degos disease 1 10.0
28 melanoma 10.0
29 inflammatory myofibroblastic tumor 10.0 S100B S100A1
30 dermatofibrosarcoma protuberans 10.0 S100B S100A1
31 atypical teratoid rhabdoid tumor 10.0 S100B S100A1
32 basal cell nevus syndrome 10.0
33 retinal detachment 10.0
34 xeroderma pigmentosum, variant type 10.0
35 astigmatism 10.0
36 intraocular pressure quantitative trait locus 10.0
37 dysplastic nevus syndrome 10.0
38 siderosis 10.0
39 uveitis 10.0
40 iritis 10.0
41 malignant choroid melanoma 10.0
42 malignant ciliary body melanoma 10.0
43 adenoma 10.0
44 iridocyclitis 10.0
45 iridocorneal endothelial syndrome 10.0
46 posttransplant acute limbic encephalitis 10.0
47 nevus of ota 10.0
48 overgrowth syndrome 10.0
49 essential iris atrophy 10.0
50 plexiform neurofibroma 10.0 SPRED1 S100B

Graphical network of the top 20 diseases related to Malignant Iris Melanoma:



Diseases related to Malignant Iris Melanoma

Symptoms & Phenotypes for Malignant Iris Melanoma

Drugs & Therapeutics for Malignant Iris Melanoma

Search Clinical Trials , NIH Clinical Center for Malignant Iris Melanoma

Genetic Tests for Malignant Iris Melanoma

Anatomical Context for Malignant Iris Melanoma

MalaCards organs/tissues related to Malignant Iris Melanoma:

40
Endothelial

Publications for Malignant Iris Melanoma

Articles related to Malignant Iris Melanoma:

(show top 50) (show all 130)
# Title Authors PMID Year
1
Neurofibromatosis type 1 and melanoma of the iris arising from a dysplastic nevus: A rare yet casual association? 61
32064917 2020
2
[Nevus or Melanoma of the Iris? A Progressive Course Over at Least 43 Years]. 61
29723886 2019
3
Tapioca Melanoma of the Iris: A Case Report. 61
31660116 2019
4
A Case of a Cavitary Iris Melanoma with Aqueous Cytological Modulation. 61
31049323 2019
5
Iris melanoma presenting as childhood glaucoma. 61
30023461 2018
6
Regression Patterns of Iris Melanoma after Palladium-103 (103Pd) Plaque Brachytherapy. 61
28377036 2017
7
Tapioca melanoma of the iris without iris heterochromia. 61
24584308 2014
8
Baerveldt shunts in the treatment of glaucoma secondary to anterior uveal melanoma and proton beam radiotherapy. 61
22628537 2012
9
Clinical and pathologic characteristics of biopsy-proven iris melanoma: a multicenter international study. 61
21911649 2012
10
Plaque radiotherapy treatment with ruthenium-106 for iris malignant melanoma. 61
21941358 2011
11
A modified COMS plaque for iris melanoma. 61
23346122 2011
12
Iris mammillations in two female siblings with congenital adrenal hyperplasia. 61
22802477 2010
13
Complete ring cyst of iris pigment epithelium documented by ultrasound biomicroscopy. 61
19772275 2009
14
The in vivo modulatory effects of an anterior-chamber microenvironment on uveal melanoma. 61
19019926 2009
15
Tapioca melanoma of the iris. 61
19278465 2009
16
[Immunohistochemical detection of the gene p53 and p21 expression in cells of the malignant melanoma of the uvea]. 61
18780655 2008
17
Retained intraocular foreign body masquerading as malignant melanoma of the iris. 61
18087713 2008
18
[Foreign bodies of the iris as a rare differential diagnosis of malignant melanoma of the iris]. 61
17516375 2007
19
Punch biopsy of iris lesions: a novel technique for obtaining histology samples. 61
17446506 2007
20
Sympathetic ophthalmia after surgical resection of iridociliary melanoma. A case report. 61
16523295 2006
21
Tapioca melanoma of the iris mimicking a vascular tumour: a clinicopathological correlation. 61
15180848 2004
22
Ultrasound biomicroscopy in management of malignant iris melanoma. 61
12742854 2003
23
[Melanoma of the iris and pregnancy]. 61
12746604 2003
24
[Clinical analysis of tumors of the iris and ciliary body]. 61
12783684 2003
25
[Sarcoid granuloma simulating amelanotic melanoma of the iris: a case report]. 61
12471352 2002
26
p53 Immunoreactivity, Ki-67 expression, and microcirculation patterns in melanoma of the iris, ciliary body, and choroid. 61
12187481 2002
27
Plaque radiation therapy for malignant melanoma of the iris and ciliary body. 61
11530044 2001
28
Unusual presentation of diffuse melanoma of the iris. 61
11032442 2000
29
[Surgical treatment of pigmented tumors of the iris and iridociliary region]. 61
10596477 1999
30
Adenoma of the nonpigmented ciliary epithelium mimicking a malignant melanoma of the iris. 61
9930172 1999
31
Ultrasound biomicroscopy in the management of malignant melanoma of the iris. 61
7487612 1995
32
Iris melanoma in ocular melanocytosis. 61
7743806 1995
33
Aspiration cytopathology of malignant melanoma in children. A morphologic spectrum. 61
7856568 1995
34
Intraocular T-cell lymphoma mimicking a ring melanoma. First manifestation of systemic disease. Report of a case and survey of the literature. 61
8188064 1994
35
Malignant melanoma of the iris. A 25-year analysis of Danish cases. 61
8142742 1993
36
Ocular melanoma in childhood. 61
8363486 1993
37
[Melanoma of the iris with recurrent hyphema--course over 32 years]. 61
8231044 1993
38
Tapioca melanoma of the iris. 61
8517592 1993
39
[Results of surgical treatment for anterior uveal malignant melanoma]. 61
1845319 1991
40
S100 immunophenotypes of uveal melanomas. 61
1696942 1990
41
[Conservative treatment of a malignant melanoma of the iris in a 4-year-old child]. 61
2366487 1990
42
Diffuse malignant melanoma of iris with metastases. 61
2183381 1990
43
Melanoma of the iris. 61
2765434 1989
44
[Malignant iridic melanoma]. 61
2532772 1989
45
[Is iris melanoma really a nevus?]. 61
2722076 1989
46
Malignant melanoma of the iris in xeroderma pigmentosum. 61
2923565 1989
47
Diffuse uveal melanoma in a 5-year-old child. 61
3189476 1988
48
[Tapioca melanoma of the iris]. 61
3048718 1988
49
[Tapioca melanoma of the iris]. 61
2973640 1988
50
Enlargement of melanocytic iris lesions. 61
3684181 1987

Variations for Malignant Iris Melanoma

Expression for Malignant Iris Melanoma

Search GEO for disease gene expression data for Malignant Iris Melanoma.

Pathways for Malignant Iris Melanoma

Pathways related to Malignant Iris Melanoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.9 S100B S100A1 GNAO1

GO Terms for Malignant Iris Melanoma

Cellular components related to Malignant Iris Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.13 S100A1 GNAO1 CAV2
2 caveola GO:0005901 8.62 SPRED1 CAV2

Biological processes related to Malignant Iris Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 8.96 SPRED1 CAV2
2 regulation of heart contraction GO:0008016 8.62 S100A1 GNAO1

Molecular functions related to Malignant Iris Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein homodimerization activity GO:0042803 9.33 S100B S100A1 CAV2
2 calcium-dependent protein binding GO:0048306 8.96 S100B S100A1
3 S100 protein binding GO:0044548 8.62 S100B S100A1

Sources for Malignant Iris Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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