MCID: MLG071
MIFTS: 24

Malignant Leptomeningeal Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Malignant Leptomeningeal Tumor

MalaCards integrated aliases for Malignant Leptomeningeal Tumor:

Name: Malignant Leptomeningeal Tumor 12 15
Malignant Tumour of Leptomeninges 12
Malignant Leptomeningeal Neoplasm 70
Malignant Tumor of Leptomeninges 12
Malignant Leptomeningeal Tumour 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6086
NCIt 50 C8506
UMLS 70 C1334596

Summaries for Malignant Leptomeningeal Tumor

MalaCards based summary : Malignant Leptomeningeal Tumor, also known as malignant tumour of leptomeninges, is related to phakomatosis cesioflammea and hypocalciuric hypercalcemia, familial, type ii. An important gene associated with Malignant Leptomeningeal Tumor is GNAQ (G Protein Subunit Alpha Q), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and Pathways in cancer. Related phenotypes are integument and craniofacial

Related Diseases for Malignant Leptomeningeal Tumor

Diseases related to Malignant Leptomeningeal Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 phakomatosis cesioflammea 10.1 GNAQ GNA11
2 hypocalciuric hypercalcemia, familial, type ii 10.0 GNAQ GNA11
3 weber syndrome 10.0 GNAQ GNA11
4 sturge-weber syndrome 10.0 GNAQ GNA11
5 familial hypocalciuric hypercalcemia 10.0 GNAQ GNA11
6 sensory organ benign neoplasm 10.0 NRAS MLANA
7 nevus, epidermal 10.0 NRAS GNAQ
8 hypomelanosis of ito 9.8 NRAS GNAQ GNA11
9 melanocytic nevus syndrome, congenital 9.8 TYR NRAS
10 mucosal melanoma 9.8 NRAS GNAQ GNA11
11 ocular melanoma 9.8 NRAS GNAQ GNA11
12 ciliary body cancer 9.8 TYR MLANA
13 conjunctival nevus 9.8 NRAS MLANA GNAQ
14 melanoacanthoma 9.8 TYR MLANA
15 halo nevi 9.8 TYR MLANA
16 sarcomatoid transitional cell carcinoma 9.8 TYR MLANA
17 spinal cord melanoma 9.8 TYR MLANA
18 diffuse meningeal melanocytosis 9.8 TYR MLANA
19 meningeal melanocytoma 9.7 MLANA GNAQ GNA11
20 orofacial cleft 8 9.7 TYR MLANA
21 mongolian spot 9.7 MLANA GNAQ GNA11
22 malignant anus melanoma 9.7 NRAS MLANA GNA11
23 amelanotic melanoma 9.7 TYR MLANA
24 keratosis, seborrheic 9.7 TYR MLANA
25 ocular cancer 9.7 MLANA GNAQ GNA11
26 angiomyolipoma 9.7 TYR MLANA
27 clear cell sarcoma 9.7 TYR MLANA
28 skin benign neoplasm 9.7 TYR MLANA
29 adrenal carcinoma 9.6 NRAS MLANA
30 neurofibroma 9.6 TYR MLANA
31 vitiligo-associated multiple autoimmune disease susceptibility 1 9.6 TYR MLANA
32 ocular albinism 9.5 TYR MLANA
33 meningeal melanomatosis 9.5 NRAS MLANA GNAQ GNA11
34 malignant dermis tumor 9.5 NRAS MLANA GNAQ GNA11
35 malignant skin fibrous histiocytoma 9.5 NRAS MLANA GNAQ GNA11
36 epithelioid cell melanoma 9.5 TYR MLANA GNA11
37 vulvar melanoma 9.5 NRAS MLANA GNAQ GNA11
38 malignant conjunctival melanoma 9.5 NRAS MLANA GNAQ GNA11
39 spitzoid melanoma 9.5 NRAS MLANA GNAQ GNA11
40 conjunctival cancer 9.5 NRAS MLANA GNAQ GNA11
41 large congenital melanocytic nevus 9.5 NRAS MLANA GNAQ GNA11
42 uveal disease 9.4 TYR NRAS GNAQ GNA11
43 orbit rhabdomyosarcoma 9.3 TYR NRAS MLANA GNAQ
44 melanoma in congenital melanocytic nevus 9.3 TYR NRAS MLANA GNAQ
45 central nervous system melanocytic neoplasm 9.2 NRAS MLANA GTPBP4 GNAQ GNA11
46 melanoma 9.1 TYR NRAS MLANA GNAQ GNA11
47 melanomatosis 9.1 TYR NRAS MLANA GTPBP4 GNAQ
48 malignant spindle cell melanoma 9.1 TYR NRAS MLANA GNAQ GNA11
49 nodular malignant melanoma 9.1 TYR NRAS MLANA GNAQ GNA11
50 melanoma, cutaneous malignant 1 9.1 TYR NRAS MLANA GNAQ GNA11

Graphical network of the top 20 diseases related to Malignant Leptomeningeal Tumor:



Diseases related to Malignant Leptomeningeal Tumor

Symptoms & Phenotypes for Malignant Leptomeningeal Tumor

MGI Mouse Phenotypes related to Malignant Leptomeningeal Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.63 GNA11 GNAQ GTPBP4 MLANA NRAS TYR
2 craniofacial MP:0005382 9.56 GNA11 GNAQ NRAS TYR
3 limbs/digits/tail MP:0005371 9.26 GNA11 GNAQ NRAS TYR
4 pigmentation MP:0001186 9.1 GNA11 GNAQ GTPBP4 MLANA NRAS TYR

Drugs & Therapeutics for Malignant Leptomeningeal Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Leptomeningeal Tumor

Genetic Tests for Malignant Leptomeningeal Tumor

Anatomical Context for Malignant Leptomeningeal Tumor

Publications for Malignant Leptomeningeal Tumor

Articles related to Malignant Leptomeningeal Tumor:

# Title Authors PMID Year
1
Fatal leptomeningeal melanoma in neurocutaneous melanosis. 61
21906139 2012
2
[Treatment of a rat meningeal gliomatosis model with neocarzinostatin]. 61
2960332 1987

Variations for Malignant Leptomeningeal Tumor

Expression for Malignant Leptomeningeal Tumor

Search GEO for disease gene expression data for Malignant Leptomeningeal Tumor.

Pathways for Malignant Leptomeningeal Tumor

Pathways related to Malignant Leptomeningeal Tumor according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.53 NRAS GNAQ GNA11
2 12.49 NRAS GNAQ GNA11
3
Show member pathways
12.48 NRAS GNAQ GNA11
4
Show member pathways
12.42 NRAS GNAQ GNA11
5
Show member pathways
12.33 NRAS GNAQ GNA11
6
Show member pathways
12.33 TYR NRAS GNAQ GNA11
7
Show member pathways
12.29 NRAS GNAQ GNA11
8
Show member pathways
12.09 NRAS GNAQ GNA11
9 11.64 GNAQ GNA11
10 11.61 GNAQ GNA11
11
Show member pathways
11.61 NRAS GNAQ GNA11
12 11.56 GNAQ GNA11
13 11.38 GNAQ GNA11
14 11.38 NRAS GNAQ GNA11
15 11.28 NRAS GNAQ GNA11
16 11.24 GNAQ GNA11
17 11.09 GNAQ GNA11
18 11.02 GNAQ GNA11
19 10.96 GNAQ GNA11
20 10.94 NRAS GNAQ GNA11
21 10.71 NRAS GNAQ
22 10.58 NRAS GNAQ GNA11
23
Show member pathways
10.57 GNAQ GNA11

GO Terms for Malignant Leptomeningeal Tumor

Cellular components related to Malignant Leptomeningeal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 9.16 TYR MLANA
2 photoreceptor outer segment GO:0001750 8.96 GNAQ GNA11
3 heterotrimeric G-protein complex GO:0005834 8.62 GNAQ GNA11

Biological processes related to Malignant Leptomeningeal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 adenylate cyclase-modulating G protein-coupled receptor signaling pathway GO:0007188 9.32 GNAQ GNA11
2 action potential GO:0001508 9.26 GNAQ GNA11
3 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.16 GNAQ GNA11
4 phototransduction, visible light GO:0007603 8.96 GNAQ GNA11
5 entrainment of circadian clock GO:0009649 8.62 GNAQ GNA11

Molecular functions related to Malignant Leptomeningeal Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 GTP binding GO:0005525 9.46 NRAS GTPBP4 GNAQ GNA11
2 G protein-coupled receptor binding GO:0001664 9.37 GNAQ GNA11
3 G-protein beta/gamma-subunit complex binding GO:0031683 9.32 GNAQ GNA11
4 guanyl nucleotide binding GO:0019001 9.26 GNAQ GNA11
5 type 2A serotonin receptor binding GO:0031826 8.96 GNAQ GNA11
6 GTPase activity GO:0003924 8.92 NRAS GTPBP4 GNAQ GNA11

Sources for Malignant Leptomeningeal Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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