MCID: MLG072
MIFTS: 31

Malignant Leydig Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Malignant Leydig Cell Tumor

MalaCards integrated aliases for Malignant Leydig Cell Tumor:

Name: Malignant Leydig Cell Tumor 12 15
Leydig Cell Tumor, Malignant 12 72
Malignant Interstitial Cell Tumor 12
Malignant Leydig Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050616
NCIt 50 C4213
SNOMED-CT 68 77870005
UMLS 72 C0334410

Summaries for Malignant Leydig Cell Tumor

Disease Ontology : 12 A sex cord-gonadal stromal tumor that secretes testosterone characterized by excessive proliferation of Leydig cells located in ovary or testicle.

MalaCards based summary : Malignant Leydig Cell Tumor, also known as leydig cell tumor, malignant, is related to malignant testicular leydig cell tumor and brain germinoma. An important gene associated with Malignant Leydig Cell Tumor is PAX5 (Paired Box 5), and among its related pathways/superpathways are NF-kappaB Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary, ovary and testis, and related phenotypes are neoplasm and normal

Related Diseases for Malignant Leydig Cell Tumor

Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Malignant Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 malignant testicular leydig cell tumor 11.5
2 brain germinoma 10.7 POU5F1 AFP
3 extragonadal germ cell cancer 10.7 POU5F1 AFP
4 malignant sertoli cell tumor 10.7 SYP AFP
5 embryonal testis carcinoma 10.7 POU5F1 AFP
6 ovary neuroendocrine neoplasm 10.7 SYP KRT7
7 central nervous system primitive neuroectodermal neoplasm 10.7 SYP NES
8 dysembryoplastic neuroepithelial tumor 10.7 SYP NES
9 ovarian germ cell cancer 10.7 KRT7 AFP
10 small cell carcinoma of the bladder 10.7 SYP KRT7
11 mixed germ cell tumor 10.7 KIT AFP
12 lung combined type small cell carcinoma 10.7 SYP MME
13 astroblastoma 10.6 SYP NES
14 middle ear adenoma 10.6 SYP KRT7
15 sensory organ benign neoplasm 10.6 SYP KRT7
16 mixed hepatoblastoma 10.6 PGR AFP
17 leydig cell tumor 10.6
18 extrahepatic bile duct adenocarcinoma 10.6 SYP MME
19 gallbladder small cell carcinoma 10.6 SYP KRT7
20 cervical adenoma malignum 10.6 MME KRT7
21 hepatic angiomyolipoma 10.6 KIT AFP
22 ceruminoma 10.6 KRT7 KIT
23 cutaneous ganglioneuroma 10.6 SYP KIT
24 jejunal cancer 10.6 KRT7 KIT
25 clear cell papillary renal cell carcinoma 10.6 MME KRT7
26 eccrine papillary adenocarcinoma 10.6 PGR KRT7
27 mature teratoma 10.6 POU5F1 AFP
28 adenofibroma 10.6 MME CALB2
29 cervical mucinous adenocarcinoma 10.6 MME KRT7
30 mixed type thymoma 10.6 SYP KIT
31 male reproductive organ benign neoplasm 10.6 SYP AFP
32 subependymoma 10.6 SYP NES
33 oncocytic breast carcinoma 10.6 PGR KRT7
34 endosalpingiosis 10.6 PGR KRT7
35 central nervous system germ cell tumor 10.6 POU5F1 NES AFP
36 olfactory groove meningioma 10.6 SYP PGR
37 choriocarcinoma of the testis 10.6 KRT7 AFP
38 myxoid leiomyosarcoma 10.6 PGR MME
39 pulmonary sclerosing hemangioma 10.5 SYP KRT7
40 pancreatoblastoma 10.5 SYP AFP
41 benign metastasizing leiomyoma 10.5 PGR KRT7
42 adenomyoma 10.5 MME KRT7
43 fallopian tube endometrioid adenocarcinoma 10.5 MME CALB2
44 ovarian fibrothecoma 10.5 KIT CALB2
45 tuberculum sellae meningioma 10.5 SYP PGR
46 sella turcica neoplasm 10.5 SYP PGR
47 malignant teratoma 10.5 SYP POU5F1 AFP
48 cll/sll 10.5 PAX5 MME
49 pineoblastoma 10.5 SYP POU5F1 AFP
50 mucinous cystadenofibroma 10.5 CEACAM5 AFP

Graphical network of the top 20 diseases related to Malignant Leydig Cell Tumor:



Diseases related to Malignant Leydig Cell Tumor

Symptoms & Phenotypes for Malignant Leydig Cell Tumor

MGI Mouse Phenotypes related to Malignant Leydig Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.43 AFP KIT KRT19 PAX5 PGR SPN
2 normal MP:0002873 9.17 CALB2 KIT KRT19 PAX5 PGR POU5F1

Drugs & Therapeutics for Malignant Leydig Cell Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Leydig Cell Tumor

Genetic Tests for Malignant Leydig Cell Tumor

Anatomical Context for Malignant Leydig Cell Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Malignant Leydig Cell Tumor:

19
Ovary

MalaCards organs/tissues related to Malignant Leydig Cell Tumor:

41
Ovary, Testis

Publications for Malignant Leydig Cell Tumor

Articles related to Malignant Leydig Cell Tumor:

(show all 31)
# Title Authors PMID Year
1
Malignant Leydig cell tumor in dogs: two cases and a review of the literature. 38
31248354 2019
2
Fine needle aspiration diagnosis of metastatic Leydig cell tumor. Report of a case and review of the literature. 38
31272604 2019
3
Retroperitoneal Leydig cell tumor recurrence presenting 14 years after orchiectomy. 38
29524977 2018
4
[Malignant Leydig Cell Tumor of the Testis : A Case Report]. 38
27320121 2016
5
[Testicular malignant Leydig cell tumor: A case report]. 38
27416670 2016
6
Metastasized Leydig cell tumor in a dog. 38
26753337 2015
7
Malignant Leydig-cell tumor of the testis diagnosed by fine-needle aspiration using ThinPrep technique. 38
20730900 2011
8
Malignant Leydig cell tumor with spindle-shaped cells in a male CD-1 mouse. 38
20075603 2010
9
Recurrent malignant Leydig cell tumor of testis: a case report with review of literature. 38
20164008 2010
10
Unilateral malignant leydig cell tumor of testis in a patient with contralateral cryptorchidism. 38
19241346 2009
11
A patient with ectopic cortisol production derived from malignant testicular masses. 38
18941436 2008
12
Fine needle aspiration of metastatic malignant Leydig cell tumor of testis: a case report. 38
17883165 2007
13
Lack of efficacy of imatinib in a patient with metastatic Leydig cell tumor. 38
16450163 2006
14
A malignant Leydig cell tumor of the testis. 38
16868700 2006
15
Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. 38
15721441 2005
16
Metastatic Leydig cell tumor of the testicle in a young African American male. 38
14704114 2003
17
Leydig cell tumor: a case report and review of the literature. 38
12004857 2002
18
Malignant Leydig cell tumor of the testis associated with Klinefelter's syndrome. 38
10650798 1999
19
[Malignant Leydig cell tumor. Report of a case and review of the literature]. 38
10218284 1999
20
[Malignant Leydig cell tumor of the testis secreting progesterone]. 38
9894267 1998
21
Metachronous development of malignant Leydig cell tumor. 38
9385943 1997
22
[Bilateral testicular Leydig cell tumor with adrenocortical adenoma: a case report]. 38
7702009 1995
23
Case report: congenital adrenal hyperplasia and malignant Leydig cell tumor. 38
7825657 1995
24
[Malignant Leydig cell tumor]. 38
7748005 1994
25
Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane. 38
1404649 1992
26
Treatment of malignant Leydig cell tumor. 38
1913469 1991
27
[Malignant Leydig cell tumor. A case observed at the Dakar University Hospital]. 38
2064367 1991
28
Malignant feminizing Leydig cell tumor. 38
6482460 1984
29
Malignant Leydig cell tumor: clinical, histologic and electron microscopic features. 38
7055782 1982
30
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. 38
7226052 1981
31
Malignant Leydig cell tumor in a 94-year-old man. 38
470029 1979

Variations for Malignant Leydig Cell Tumor

Expression for Malignant Leydig Cell Tumor

Search GEO for disease gene expression data for Malignant Leydig Cell Tumor.

Pathways for Malignant Leydig Cell Tumor

GO Terms for Malignant Leydig Cell Tumor

Cellular components related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection terminus GO:0044306 8.62 SYP MME

Biological processes related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 8.96 TNFRSF8 SPN
2 ovulation from ovarian follicle GO:0001542 8.62 PGR AFP

Sources for Malignant Leydig Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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