Malignant Leydig Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Malignant Leydig Cell Tumor

MalaCards integrated aliases for Malignant Leydig Cell Tumor:

Name: Malignant Leydig Cell Tumor ¹² ¹⁵

Leydig Cell Tumor, Malignant ¹² ⁷³

Malignant Interstitial Cell Tumor ¹²

Malignant Leydig Cell Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050616

NCIt ⁵⁰ C4213

SNOMED-CT ⁶⁸ 77870005

UMLS ⁷³ C0334410

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Summaries for Malignant Leydig Cell Tumor

Disease Ontology : ¹² A sex cord-gonadal stromal tumor that secretes testosterone characterized by excessive proliferation of Leydig cells located in ovary or testicle.

MalaCards based summary : Malignant Leydig Cell Tumor, also known as leydig cell tumor, malignant, is related to malignant testicular leydig cell tumor and leydig cell tumor. An important gene associated with Malignant Leydig Cell Tumor is PAX5 (Paired Box 5), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary, testis and lung, and related phenotype is neoplasm.

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Related Diseases for Malignant Leydig Cell Tumor

Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Malignant Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 147)

#	Related Disease	Score	Top Affiliating Genes
1	malignant testicular leydig cell tumor	11.3
2	leydig cell tumor	10.5
3	medulloepithelioma	10.2	KRT7 NES
4	cystadenoma	10.2	KRT7 MME
5	balloon cell malignant melanoma	10.2	KRT7 MME
6	cll/sll	10.2	MME PAX5
7	cervical adenoma malignum	10.2	KRT7 MME
8	cervical mucinous adenocarcinoma	10.2	KRT7 MME
9	clear cell papillary renal cell carcinoma	10.2	KRT7 MME
10	adenomyoma	10.2	KRT7 MME
11	ceruminoma	10.2	KIT KRT7
12	jejunal cancer	10.2	KIT KRT7
13	cribriform carcinoma	10.2	KIT KRT7
14	central nervous system germinoma	10.2	POMC POU5F1
15	kidney benign neoplasm	10.2	KRT7 MME
16	breast adenomyoepithelioma	10.2	KRT7 MME
17	benign breast phyllodes tumor	10.2	KIT MME
18	breast myoepithelial neoplasm	10.2	KRT7 MME
19	eccrine sweat gland neoplasm	10.2	KRT7 MME
20	warthin tumor	10.2	KIT KRT7
21	cystic nephroma	10.2	KIT MME
22	infiltrative basal cell carcinoma	10.2	KRT7 MME
23	sarcomatoid squamous cell skin carcinoma	10.2	MME POU5F1
24	perivascular epithelioid cell tumor	10.2	KIT MME
25	collecting duct carcinoma	10.2	KRT7 MME
26	dermoid cyst	10.2	KIT KRT7
27	childhood disintegrative disease	10.2	MME POMC
28	papillary hidradenoma	10.2	KIT MME
29	adenosarcoma	10.2	KIT MME
30	adenofibroma	10.2	CALB2 MME
31	myeloid sarcoma	10.2	KIT PAX5
32	venous hemangioma	10.2	CALB2 POU5F1
33	prostatic acinar adenocarcinoma	10.2	KIT KRT7
34	bile duct cystadenocarcinoma	10.2	CALB2 KRT7
35	fallopian tube endometrioid adenocarcinoma	10.2	CALB2 MME
36	cervix endometriosis	10.1	CALB2 MME
37	malignant biphasic mesothelioma	10.1	CALB2 KRT7
38	adenomatoid tumor	10.1	CALB2 KRT7
39	necrotizing sialometaplasia	10.1	KIT KRT7
40	fallopian tube adenocarcinoma	10.1	CALB2 MME
41	mucinous ovarian cystadenoma	10.1	CALB2 KRT7
42	cutaneous solitary mastocytoma	10.1	KIT POMC
43	clear cell adenofibroma	10.1	CALB2 KRT7
44	ovarian fibrothecoma	10.1	CALB2 KIT
45	mucinous bronchioloalveolar adenocarcinoma	10.1	CALB2 KRT7
46	ovarian melanoma	10.1	CALB2 KIT
47	large cell neuroendocrine carcinoma	10.1	KIT KRT7
48	peritoneal benign neoplasm	10.1	CALB2 KIT
49	diffuse peritoneal leiomyomatosis	10.1	CALB2 KIT
50	intrahepatic bile duct adenoma	10.1	KRT19 KRT7

Graphical network of the top 20 diseases related to Malignant Leydig Cell Tumor:

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Symptoms & Phenotypes for Malignant Leydig Cell Tumor

MGI Mouse Phenotypes related to Malignant Leydig Cell Tumor:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.02	KIT KRT19 PAX5 POMC SPN

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Drugs & Therapeutics for Malignant Leydig Cell Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Leydig Cell Tumor

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Genetic Tests for Malignant Leydig Cell Tumor

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Anatomical Context for Malignant Leydig Cell Tumor

MalaCards organs/tissues related to Malignant Leydig Cell Tumor:

⁴¹

Ovary, Testis, Lung, Kidney, Colon, B Cells, Thymus

The Foundational Model of Anatomy Ontology organs/tissues related to Malignant Leydig Cell Tumor:

¹⁹

Ovary Or Testicle

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Publications for Malignant Leydig Cell Tumor

Articles related to Malignant Leydig Cell Tumor:

(show all 14)

#	Title	Authors	Year
1	Malignant Leydig-cell tumor of the testis diagnosed by fine-needle aspiration using ThinPrep technique. ( 20730900 )		2011
2	Recurrent malignant Leydig cell tumor of testis: a case report with review of literature. ( 20164008 )	Bhat G.M....Iqbal Q.M.	2010
3	Malignant Leydig cell tumor with spindle-shaped cells in a male CD-1 mouse. ( 20075603 )		2010
4	Unilateral malignant leydig cell tumor of testis in a patient with contralateral cryptorchidism. ( 19241346 )		2009
5	Fine needle aspiration of metastatic malignant Leydig cell tumor of testis: a case report. ( 17883165 )	Naik R....Nayak S.K.	2007
6	A malignant Leydig cell tumor of the testis. ( 16868700 )	Sugimoto K....Hanai J.	2006
7	Malignant Leydig cell tumor of the testis associated with Klinefelter's syndrome. ( 10650798 )		1999
8	Metachronous development of malignant Leydig cell tumor. ( 9385943 )	Sugimura J....Satodate R.	1997
9	Case report: congenital adrenal hyperplasia and malignant Leydig cell tumor. ( 7825657 )		1995
10	Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane. ( 1404649 )		1992
11	Treatment of malignant Leydig cell tumor. ( 1913469 )		1991
12	Malignant Leydig cell tumor: clinical, histologic and electron microscopic features. ( 7055782 )		1982
13	Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ( 7226052 )	Azer P.C....Braunstein G.D.	1981
14	Malignant Leydig cell tumor in a 94-year-old man. ( 470029 )	Wogalter H....D'Esposito R.F.	1979

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Genes for Malignant Leydig Cell Tumor

Genes related to Malignant Leydig Cell Tumor (0 elite genes):

(show all 11)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PAX5	Paired Box 5	Protein Coding	14.69	DISEASES inferred ¹⁵
2	NES	Nestin	Protein Coding	14.27	DISEASES inferred ¹⁵
3	POU5F1	POU Class 5 Homeobox 1	Protein Coding	14.16	DISEASES inferred ¹⁵
4	KRT7	Keratin 7	Protein Coding	13.87	DISEASES inferred ¹⁵
5	MME	Membrane Metalloendopeptidase	Protein Coding	13.66	DISEASES inferred ¹⁵
6	KIT	KIT Proto-Oncogene Receptor Tyrosine Kinase	Protein Coding	13.43	DISEASES inferred ¹⁵
7	POMC	Proopiomelanocortin	Protein Coding	13.04	DISEASES inferred ¹⁵
8	SPN	Sialophorin	Protein Coding	4.7	DISEASES inferred ¹⁵
9	KRT19	Keratin 19	Protein Coding	3.98	DISEASES inferred ¹⁵
10	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	3.84	DISEASES inferred ¹⁵
11	CALB2	Calbindin 2	Protein Coding	2.98	DISEASES inferred ¹⁵

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Variations for Malignant Leydig Cell Tumor

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Expression for Malignant Leydig Cell Tumor

Search GEO for disease gene expression data for Malignant Leydig Cell Tumor.

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Pathways for Malignant Leydig Cell Tumor

Pathways related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.62	KRT19 NES POU5F1
2	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.5	KIT MME SPN
3	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.37	KRT19 KRT7 NES
4	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11	KIT MME SPN
5	Melanocyte Development and Pigmentation ⁶⁴	10.98	KIT POMC
6	B Cell Development Pathways ⁶⁵	10.75	KIT MME PAX5 SPN TNFRSF8

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GO Terms for Malignant Leydig Cell Tumor

Cellular components related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	8.8	KRT19 KRT7 NES

Biological processes related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of tumor necrosis factor biosynthetic process	GO:0042535	8.62	SPN TNFRSF8

Molecular functions related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine binding	GO:0019955	8.96	KIT POU5F1
2	transmembrane signaling receptor activity	GO:0004888	8.8	KIT SPN TNFRSF8

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