MCID: MLG072
MIFTS: 24

Malignant Leydig Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Malignant Leydig Cell Tumor

MalaCards integrated aliases for Malignant Leydig Cell Tumor:

Name: Malignant Leydig Cell Tumor 12 15
Leydig Cell Tumor, Malignant 12 71
Malignant Interstitial Cell Tumor 12
Malignant Leydig Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050616
NCIt 49 C4213
SNOMED-CT 67 77870005
UMLS 71 C0334410

Summaries for Malignant Leydig Cell Tumor

Disease Ontology : 12 A sex cord-gonadal stromal tumor that secretes testosterone characterized by excessive proliferation of Leydig cells located in ovary or testicle.

MalaCards based summary : Malignant Leydig Cell Tumor, also known as leydig cell tumor, malignant, is related to leydig cell tumor and malignant sertoli-leydig cell tumor. An important gene associated with Malignant Leydig Cell Tumor is CALB2 (Calbindin 2), and among its related pathways/superpathways is B Cell Development Pathways. Affiliated tissues include ovary, testis and b cells.

Related Diseases for Malignant Leydig Cell Tumor

Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Malignant Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 leydig cell tumor 31.0 CALB2 AFP
2 malignant sertoli-leydig cell tumor 11.5
3 malignant testicular leydig cell tumor 11.5
4 infant gynecomastia 10.2
5 gynecomastia 10.2
6 rare tumor 10.2
7 ovarian melanoma 10.1 MLANA CALB2
8 retroperitoneal sarcoma 10.1 MLANA CALB2
9 thymus clear cell carcinoma 10.1 MLANA CALB2
10 ovarian sex-cord stromal tumor 10.0 MLANA CALB2
11 hydrocele 10.0 CALB2 AFP
12 malignant sertoli cell tumor 10.0 CALB2 AFP
13 sertoli cell tumor 10.0 CALB2 AFP
14 rete testis neoplasm 10.0 CALB2 AFP
15 adult mesoblastic nephroma 10.0 MLANA CALB2
16 rete testis adenocarcinoma 10.0 CALB2 AFP
17 teratoma 10.0 CALB2 AFP
18 cystic teratoma 10.0 CALB2 AFP
19 dermoid cyst of ovary 10.0 CALB2 AFP
20 hematocele of tunica vaginalis testis 10.0 CALB2 AFP
21 scrotum neoplasm 10.0 CALB2 AFP
22 epididymal neoplasm 10.0 CALB2 AFP
23 ovarian germ cell teratoma 10.0 CALB2 AFP
24 benign mesothelioma 10.0 CALB2 AFP
25 cystadenofibroma 10.0 CALB2 AFP
26 epididymis adenocarcinoma 10.0 CALB2 AFP
27 epididymis cancer 10.0 CALB2 AFP
28 granular cell tumor 10.0 MLANA CALB2
29 lipoid congenital adrenal hyperplasia 10.0
30 cryptorchidism, unilateral or bilateral 10.0
31 androgen insensitivity syndrome 10.0
32 adrenal cortical carcinoma 10.0
33 hypogonadotropic hypogonadism 10.0
34 disseminated intravascular coagulation 10.0
35 amenorrhea 10.0
36 gonadal dysgenesis 10.0
37 mixed gonadal dysgenesis 10.0
38 islet cell tumor 10.0
39 seminoma 10.0
40 adenoma 10.0
41 complete androgen insensitivity syndrome 10.0
42 adrenogenital syndrome 10.0
43 tuberculous epididymitis 10.0 CALB2 AFP
44 middle ear carcinoma 10.0 CALB2 AFP
45 cardiovascular cancer 10.0 MLANA CALB2
46 mature teratoma of the ovary 10.0 MLANA AFP
47 ovarian cystic teratoma 10.0 MLANA AFP
48 cystic lymphangioma 10.0 CALB2 AFP
49 lymphangioma 10.0 CALB2 AFP
50 ovarian benign neoplasm 10.0 CALB2 AFP

Graphical network of the top 20 diseases related to Malignant Leydig Cell Tumor:



Diseases related to Malignant Leydig Cell Tumor

Symptoms & Phenotypes for Malignant Leydig Cell Tumor

Drugs & Therapeutics for Malignant Leydig Cell Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Leydig Cell Tumor

Genetic Tests for Malignant Leydig Cell Tumor

Anatomical Context for Malignant Leydig Cell Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Malignant Leydig Cell Tumor:

19
Ovary

MalaCards organs/tissues related to Malignant Leydig Cell Tumor:

40
Ovary, Testis, B Cells, Bone, Thymus, Lung, Myeloid

Publications for Malignant Leydig Cell Tumor

Articles related to Malignant Leydig Cell Tumor:

(show all 33)
# Title Authors PMID Year
1
Malignant leydig cell tumor in a 91-year-old man: Case report. 61
31808415 2019
2
Malignant Leydig cell tumor in dogs: two cases and a review of the literature. 61
31248354 2019
3
Fine needle aspiration diagnosis of metastatic Leydig cell tumor. Report of a case and review of the literature. 61
31272604 2019
4
Malignant Leydig Cell Tumor in Elderly Complete Androgen Insensitivity Patient: A Case Report. 61
31477948 2019
5
Retroperitoneal Leydig cell tumor recurrence presenting 14 years after orchiectomy. 61
29524977 2018
6
[Testicular malignant Leydig cell tumor: A case report]. 61
27416670 2016
7
[Malignant Leydig Cell Tumor of the Testis : A Case Report]. 61
27320121 2016
8
Metastasized Leydig cell tumor in a dog. 61
26753337 2015
9
Malignant Leydig-cell tumor of the testis diagnosed by fine-needle aspiration using ThinPrep technique. 61
20730900 2011
10
Malignant Leydig cell tumor with spindle-shaped cells in a male CD-1 mouse. 61
20075603 2010
11
Recurrent malignant Leydig cell tumor of testis: a case report with review of literature. 61
20164008 2010
12
Unilateral malignant leydig cell tumor of testis in a patient with contralateral cryptorchidism. 61
19241346 2009
13
A patient with ectopic cortisol production derived from malignant testicular masses. 61
18941436 2008
14
Fine needle aspiration of metastatic malignant Leydig cell tumor of testis: a case report. 61
17883165 2007
15
Lack of efficacy of imatinib in a patient with metastatic Leydig cell tumor. 61
16450163 2006
16
A malignant Leydig cell tumor of the testis. 61
16868700 2006
17
Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. 61
15721441 2005
18
Metastatic Leydig cell tumor of the testicle in a young African American male. 61
14704114 2003
19
Leydig cell tumor: a case report and review of the literature. 61
12004857 2002
20
Malignant Leydig cell tumor of the testis associated with Klinefelter's syndrome. 61
10650798 1999
21
[Malignant Leydig cell tumor. Report of a case and review of the literature]. 61
10218284 1999
22
[Malignant Leydig cell tumor of the testis secreting progesterone]. 61
9894267 1998
23
Metachronous development of malignant Leydig cell tumor. 61
9385943 1997
24
[Bilateral testicular Leydig cell tumor with adrenocortical adenoma: a case report]. 61
7702009 1995
25
Case report: congenital adrenal hyperplasia and malignant Leydig cell tumor. 61
7825657 1995
26
[Malignant Leydig cell tumor]. 61
7748005 1994
27
Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane. 61
1404649 1992
28
Treatment of malignant Leydig cell tumor. 61
1913469 1991
29
[Malignant Leydig cell tumor. A case observed at the Dakar University Hospital]. 61
2064367 1991
30
Malignant feminizing Leydig cell tumor. 61
6482460 1984
31
Malignant Leydig cell tumor: clinical, histologic and electron microscopic features. 61
7055782 1982
32
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. 61
7226052 1981
33
Malignant Leydig cell tumor in a 94-year-old man. 61
470029 1979

Variations for Malignant Leydig Cell Tumor

Expression for Malignant Leydig Cell Tumor

Search GEO for disease gene expression data for Malignant Leydig Cell Tumor.

Pathways for Malignant Leydig Cell Tumor

Pathways related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.35 SPN PAX5

GO Terms for Malignant Leydig Cell Tumor

Sources for Malignant Leydig Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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