Malignant Leydig Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MLG072 MIFTS: 31	Malignant Leydig Cell Tumor Categories: Cancer diseases, Endocrine diseases, Reproductive diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Malignant Leydig Cell Tumor

MalaCards integrated aliases for Malignant Leydig Cell Tumor:

Name: Malignant Leydig Cell Tumor ¹² ¹⁵

Leydig Cell Tumor, Malignant ¹² ⁷²

Malignant Interstitial Cell Tumor ¹²

Malignant Leydig Cell Neoplasm ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0050616

NCIt ⁵⁰ C4213

SNOMED-CT ⁶⁸ 77870005

UMLS ⁷² C0334410

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Summaries for Malignant Leydig Cell Tumor

Disease Ontology : ¹² A sex cord-gonadal stromal tumor that secretes testosterone characterized by excessive proliferation of Leydig cells located in ovary or testicle.

MalaCards based summary : Malignant Leydig Cell Tumor, also known as leydig cell tumor, malignant, is related to malignant testicular leydig cell tumor and brain germinoma. An important gene associated with Malignant Leydig Cell Tumor is PAX5 (Paired Box 5), and among its related pathways/superpathways are NF-kappaB Signaling and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include ovary, ovary and testis, and related phenotypes are neoplasm and normal

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Related Diseases for Malignant Leydig Cell Tumor

Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Malignant Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)

#	Related Disease	Score	Top Affiliating Genes
1	malignant testicular leydig cell tumor	11.5
2	brain germinoma	10.7	POU5F1 AFP
3	extragonadal germ cell cancer	10.7	POU5F1 AFP
4	malignant sertoli cell tumor	10.7	SYP AFP
5	embryonal testis carcinoma	10.7	POU5F1 AFP
6	ovary neuroendocrine neoplasm	10.7	SYP KRT7
7	central nervous system primitive neuroectodermal neoplasm	10.7	SYP NES
8	dysembryoplastic neuroepithelial tumor	10.7	SYP NES
9	ovarian germ cell cancer	10.7	KRT7 AFP
10	small cell carcinoma of the bladder	10.7	SYP KRT7
11	mixed germ cell tumor	10.7	KIT AFP
12	lung combined type small cell carcinoma	10.7	SYP MME
13	astroblastoma	10.6	SYP NES
14	middle ear adenoma	10.6	SYP KRT7
15	sensory organ benign neoplasm	10.6	SYP KRT7
16	mixed hepatoblastoma	10.6	PGR AFP
17	leydig cell tumor	10.6
18	extrahepatic bile duct adenocarcinoma	10.6	SYP MME
19	gallbladder small cell carcinoma	10.6	SYP KRT7
20	cervical adenoma malignum	10.6	MME KRT7
21	hepatic angiomyolipoma	10.6	KIT AFP
22	ceruminoma	10.6	KRT7 KIT
23	cutaneous ganglioneuroma	10.6	SYP KIT
24	jejunal cancer	10.6	KRT7 KIT
25	clear cell papillary renal cell carcinoma	10.6	MME KRT7
26	eccrine papillary adenocarcinoma	10.6	PGR KRT7
27	mature teratoma	10.6	POU5F1 AFP
28	adenofibroma	10.6	MME CALB2
29	cervical mucinous adenocarcinoma	10.6	MME KRT7
30	mixed type thymoma	10.6	SYP KIT
31	male reproductive organ benign neoplasm	10.6	SYP AFP
32	subependymoma	10.6	SYP NES
33	oncocytic breast carcinoma	10.6	PGR KRT7
34	endosalpingiosis	10.6	PGR KRT7
35	central nervous system germ cell tumor	10.6	POU5F1 NES AFP
36	olfactory groove meningioma	10.6	SYP PGR
37	choriocarcinoma of the testis	10.6	KRT7 AFP
38	myxoid leiomyosarcoma	10.6	PGR MME
39	pulmonary sclerosing hemangioma	10.5	SYP KRT7
40	pancreatoblastoma	10.5	SYP AFP
41	benign metastasizing leiomyoma	10.5	PGR KRT7
42	adenomyoma	10.5	MME KRT7
43	fallopian tube endometrioid adenocarcinoma	10.5	MME CALB2
44	ovarian fibrothecoma	10.5	KIT CALB2
45	tuberculum sellae meningioma	10.5	SYP PGR
46	sella turcica neoplasm	10.5	SYP PGR
47	malignant teratoma	10.5	SYP POU5F1 AFP
48	cll/sll	10.5	PAX5 MME
49	pineoblastoma	10.5	SYP POU5F1 AFP
50	mucinous cystadenofibroma	10.5	CEACAM5 AFP

Graphical network of the top 20 diseases related to Malignant Leydig Cell Tumor:

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Symptoms & Phenotypes for Malignant Leydig Cell Tumor

MGI Mouse Phenotypes related to Malignant Leydig Cell Tumor:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	neoplasm	MP:0002006	9.43	AFP KIT KRT19 PAX5 PGR SPN
2	normal	MP:0002873	9.17	CALB2 KIT KRT19 PAX5 PGR POU5F1

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Drugs & Therapeutics for Malignant Leydig Cell Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Leydig Cell Tumor

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Genetic Tests for Malignant Leydig Cell Tumor

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Anatomical Context for Malignant Leydig Cell Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Malignant Leydig Cell Tumor:

¹⁹

Ovary

MalaCards organs/tissues related to Malignant Leydig Cell Tumor:

⁴¹

Ovary, Testis

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Publications for Malignant Leydig Cell Tumor

Articles related to Malignant Leydig Cell Tumor:

(show all 31)

#	Title	Authors	PMID	Year
1	Malignant Leydig cell tumor in dogs: two cases and a review of the literature. ³⁸	Kudo T...Shirota K	31248354	2019
2	Fine needle aspiration diagnosis of metastatic Leydig cell tumor. Report of a case and review of the literature. ³⁸	Biemer J...Barkan GA	31272604	2019
3	Retroperitoneal Leydig cell tumor recurrence presenting 14 years after orchiectomy. ³⁸	Chakiryan NH...Liu JJ	29524977	2018
4	[Malignant Leydig Cell Tumor of the Testis : A Case Report]. ³⁸	Nakai M...Imamura Y	27320121	2016
5	[Testicular malignant Leydig cell tumor: A case report]. ³⁸	Lu W...Cai ZM	27416670	2016
6	Metastasized Leydig cell tumor in a dog. ³⁸	Togni A...Hurter K	26753337	2015
7	Malignant Leydig-cell tumor of the testis diagnosed by fine-needle aspiration using ThinPrep technique. ³⁸	Valeri RM...Destouni C	20730900	2011
8	Malignant Leydig cell tumor with spindle-shaped cells in a male CD-1 mouse. ³⁸	Ohnuma A...Harada T	20075603	2010
9	Recurrent malignant Leydig cell tumor of testis: a case report with review of literature. ³⁸	Bhat GM...Iqbal QM	20164008	2010
10	Unilateral malignant leydig cell tumor of testis in a patient with contralateral cryptorchidism. ³⁸	Efthimiou I...Christoulakis I	19241346	2009
11	A patient with ectopic cortisol production derived from malignant testicular masses. ³⁸	Jain SH...Dluhy RG	18941436	2008
12	Fine needle aspiration of metastatic malignant Leydig cell tumor of testis: a case report. ³⁸	Naik R...Nayak SK	17883165	2007
13	Lack of efficacy of imatinib in a patient with metastatic Leydig cell tumor. ³⁸	Froehner M...Wirth MP	16450163	2006
14	A malignant Leydig cell tumor of the testis. ³⁸	Sugimoto K...Hanai J	16868700	2006
15	Leydig cell tumor in an elderly patient with complete androgen insensitivity syndrome. ³⁸	Iwamoto I...Douchi T	15721441	2005
16	Metastatic Leydig cell tumor of the testicle in a young African American male. ³⁸	Lam JS...Franklin JR	14704114	2003
17	Leydig cell tumor: a case report and review of the literature. ³⁸	Rao SR...Parikh DM	12004857	2002
18	Malignant Leydig cell tumor of the testis associated with Klinefelter's syndrome. ³⁸	Soria JC...Housset M	10650798	1999
19	[Malignant Leydig cell tumor. Report of a case and review of the literature]. ³⁸	Jimenez Lopez-Lucendo N...Martin Davila F	10218284	1999
20	[Malignant Leydig cell tumor of the testis secreting progesterone]. ³⁸	Daniel L...Coulange C	9894267	1998
21	Metachronous development of malignant Leydig cell tumor. ³⁸	Sugimura J...Satodate R	9385943	1997
22	[Bilateral testicular Leydig cell tumor with adrenocortical adenoma: a case report]. ³⁸	Gotoh A...Umezu K	7702009	1995
23	Case report: congenital adrenal hyperplasia and malignant Leydig cell tumor. ³⁸	Davis JM...Stephens R	7825657	1995
24	[Malignant Leydig cell tumor]. ³⁸	Kettani S...Bertrand G	7748005	1994
25	Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane. ³⁸	van der Hem KG...Pinedo HM	1404649	1992
26	Treatment of malignant Leydig cell tumor. ³⁸	Bertram KA...Davidson H	1913469	1991
27	[Malignant Leydig cell tumor. A case observed at the Dakar University Hospital]. ³⁸	Mensah A...Farhat A	2064367	1991
28	Malignant feminizing Leydig cell tumor. ³⁸	Shapiro CM...Yoon WJ	6482460	1984
29	Malignant Leydig cell tumor: clinical, histologic and electron microscopic features. ³⁸	Feldman PS...Adelson GL	7055782	1982
30	Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ³⁸	Azer PC...Braunstein GD	7226052	1981
31	Malignant Leydig cell tumor in a 94-year-old man. ³⁸	Wogalter H...D'Esposito RF	470029	1979

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Genes for Malignant Leydig Cell Tumor

Genes related to Malignant Leydig Cell Tumor (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PAX5	Paired Box 5	Protein Coding	14.35	DISEASES inferred ¹⁵
2	NES	Nestin	Protein Coding	13.97	DISEASES inferred ¹⁵
3	POU5F1	POU Class 5 Homeobox 1	Protein Coding	13.8	DISEASES inferred ¹⁵
4	AFP	Alpha Fetoprotein	Protein Coding	13.65	DISEASES inferred ¹⁵
5	SYP	Synaptophysin	Protein Coding	13.54	DISEASES inferred ¹⁵
6	KRT7	Keratin 7	Protein Coding	13.5	DISEASES inferred ¹⁵
7	MME	Membrane Metalloendopeptidase	Protein Coding	13.35	DISEASES inferred ¹⁵
8	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	13.09	DISEASES inferred ¹⁵
9	PGR	Progesterone Receptor	Protein Coding	13.06	DISEASES inferred ¹⁵
10	CALB2	Calbindin 2	Protein Coding	4.59	DISEASES inferred ¹⁵
11	SPN	Sialophorin	Protein Coding	4.38	DISEASES inferred ¹⁵
12	MLANA	Melan-A	Protein Coding	4.08	DISEASES inferred ¹⁵
13	KRT19	Keratin 19	Protein Coding	3.63	DISEASES inferred ¹⁵
14	TNFRSF8	TNF Receptor Superfamily Member 8	Protein Coding	3.52	DISEASES inferred ¹⁵
15	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	2.98	DISEASES inferred ¹⁵

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Variations for Malignant Leydig Cell Tumor

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Expression for Malignant Leydig Cell Tumor

Search GEO for disease gene expression data for Malignant Leydig Cell Tumor.

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Pathways for Malignant Leydig Cell Tumor

Pathways related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	NF-kappaB Signaling ⁴	12.07	TNFRSF8 PAX5 MLANA KIT CEACAM5
2	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.68	POU5F1 NES KRT19 AFP
3	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.58	NES KRT7 KRT19
4	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.37	SPN MME KIT
5	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.32	SPN MME KIT CEACAM5
6	B Cell Development Pathways ⁶⁵	10.75	TNFRSF8 SPN PAX5 MME KIT

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GO Terms for Malignant Leydig Cell Tumor

Cellular components related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	neuron projection terminus	GO:0044306	8.62	SYP MME

Biological processes related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of tumor necrosis factor biosynthetic process	GO:0042535	8.96	TNFRSF8 SPN
2	ovulation from ovarian follicle	GO:0001542	8.62	PGR AFP

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Sources for Malignant Leydig Cell Tumor

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