MCID: MLG072
MIFTS: 29

Malignant Leydig Cell Tumor

Categories: Cancer diseases, Reproductive diseases, Endocrine diseases

Aliases & Classifications for Malignant Leydig Cell Tumor

MalaCards integrated aliases for Malignant Leydig Cell Tumor:

Name: Malignant Leydig Cell Tumor 12 15
Leydig Cell Tumor, Malignant 12 73
Malignant Interstitial Cell Tumor 12
Malignant Leydig Cell Neoplasm 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050616
NCIt 50 C4213
SNOMED-CT 68 77870005
UMLS 73 C0334410

Summaries for Malignant Leydig Cell Tumor

MalaCards based summary : Malignant Leydig Cell Tumor, also known as leydig cell tumor, malignant, is related to malignant testicular leydig cell tumor and medulloepithelioma. An important gene associated with Malignant Leydig Cell Tumor is PAX5 (Paired Box 5), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include testis, and related phenotype is neoplasm.

Related Diseases for Malignant Leydig Cell Tumor

Diseases in the Leydig Cell Tumor family:

Malignant Leydig Cell Tumor

Diseases related to Malignant Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 133)
# Related Disease Score Top Affiliating Genes
1 malignant testicular leydig cell tumor 11.2
2 medulloepithelioma 10.7 KRT7 NES
3 balloon cell malignant melanoma 10.7 KRT7 MME
4 cll/sll 10.7 MME PAX5
5 cervical adenoma malignum 10.7 KRT7 MME
6 cervical mucinous adenocarcinoma 10.7 KRT7 MME
7 clear cell papillary renal cell carcinoma 10.7 KRT7 MME
8 adenomyoma 10.7 KRT7 MME
9 jejunal cancer 10.6 KIT KRT7
10 cribriform carcinoma 10.6 KIT KRT7
11 malignant mixed mullerian tumor 10.6 KIT KRT7
12 central nervous system germinoma 10.6 POMC POU5F1
13 breast adenomyoepithelioma 10.6 KRT7 MME
14 benign breast phyllodes tumor 10.6 KIT MME
15 breast myoepithelial neoplasm 10.6 KRT7 MME
16 cystic nephroma 10.6 KIT MME
17 infiltrative basal cell carcinoma 10.6 KRT7 MME
18 pleomorphic carcinoma 10.6 KIT KRT7
19 perivascular epithelioid cell tumor 10.6 KIT MME
20 collecting duct carcinoma 10.5 KRT7 MME
21 myeloid sarcoma 10.5 KIT PAX5
22 papillary hidradenoma 10.5 KIT MME
23 dermoid cyst 10.5 KIT KRT7
24 childhood disintegrative disease 10.5 MME POMC
25 adenosarcoma 10.5 KIT MME
26 venous hemangioma 10.5 CALB2 POU5F1
27 mucinous bronchioloalveolar adenocarcinoma 10.5 CALB2 KRT7
28 necrotizing sialometaplasia 10.5 KIT KRT7
29 bile duct cystadenocarcinoma 10.5 CALB2 KRT7
30 fallopian tube endometrioid adenocarcinoma 10.5 CALB2 MME
31 cervix endometriosis 10.5 CALB2 MME
32 mucinous ovarian cystadenoma 10.5 CALB2 KRT7
33 adenomatoid tumor 10.5 CALB2 KRT7
34 large cell neuroendocrine carcinoma 10.5 KIT KRT7
35 cutaneous solitary mastocytoma 10.5 KIT POMC
36 adenofibroma 10.4 CALB2 MME
37 nephrogenic adenofibroma 10.4 KRT7 MME
38 ovarian fibrothecoma 10.4 CALB2 KIT
39 fallopian tube adenocarcinoma 10.4 CALB2 MME
40 spindle cell synovial sarcoma 10.4 KIT KRT7
41 sertoli-leydig cell tumor 10.4 CALB2 KRT7
42 ovarian melanoma 10.4 CALB2 KIT
43 malignant biphasic mesothelioma 10.4 CALB2 KRT7
44 germ cell and embryonal cancer 10.4 KRT7 POU5F1
45 intrahepatic bile duct adenoma 10.4 KRT19 KRT7
46 anal gland adenocarcinoma 10.4 KRT19 KRT7
47 proliferating trichilemmal cyst 10.4 KRT19 KRT7
48 clear cell adenofibroma 10.4 CALB2 KRT7
49 leydig cell tumor 10.4
50 anus adenocarcinoma 10.4 KRT19 KRT7

Graphical network of the top 20 diseases related to Malignant Leydig Cell Tumor:



Diseases related to Malignant Leydig Cell Tumor

Symptoms & Phenotypes for Malignant Leydig Cell Tumor

MGI Mouse Phenotypes related to Malignant Leydig Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 9.02 KIT KRT19 PAX5 POMC SPN

Drugs & Therapeutics for Malignant Leydig Cell Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Leydig Cell Tumor

Genetic Tests for Malignant Leydig Cell Tumor

Anatomical Context for Malignant Leydig Cell Tumor

MalaCards organs/tissues related to Malignant Leydig Cell Tumor:

41
Testis

Publications for Malignant Leydig Cell Tumor

Articles related to Malignant Leydig Cell Tumor:

(show all 14)
# Title Authors Year
1
Malignant Leydig-cell tumor of the testis diagnosed by fine-needle aspiration using ThinPrep technique. ( 20730900 )
2011
2
Recurrent malignant Leydig cell tumor of testis: a case report with review of literature. ( 20164008 )
2010
3
Malignant Leydig cell tumor with spindle-shaped cells in a male CD-1 mouse. ( 20075603 )
2010
4
Unilateral malignant leydig cell tumor of testis in a patient with contralateral cryptorchidism. ( 19241346 )
2009
5
Fine needle aspiration of metastatic malignant Leydig cell tumor of testis: a case report. ( 17883165 )
2007
6
A malignant Leydig cell tumor of the testis. ( 16868700 )
2006
7
Malignant Leydig cell tumor of the testis associated with Klinefelter's syndrome. ( 10650798 )
1999
8
Metachronous development of malignant Leydig cell tumor. ( 9385943 )
1997
9
Case report: congenital adrenal hyperplasia and malignant Leydig cell tumor. ( 7825657 )
1995
10
Malignant Leydig cell tumor of the testis in complete remission on o,p'-dichlorodiphenyl-dichloroethane. ( 1404649 )
1992
11
Treatment of malignant Leydig cell tumor. ( 1913469 )
1991
12
Malignant Leydig cell tumor: clinical, histologic and electron microscopic features. ( 7055782 )
1982
13
Malignant Leydig cell tumor: objective tumor response to o,p'-DDD. ( 7226052 )
1981
14
Malignant Leydig cell tumor in a 94-year-old man. ( 470029 )
1979

Variations for Malignant Leydig Cell Tumor

Expression for Malignant Leydig Cell Tumor

Search GEO for disease gene expression data for Malignant Leydig Cell Tumor.

Pathways for Malignant Leydig Cell Tumor

GO Terms for Malignant Leydig Cell Tumor

Cellular components related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT19 KRT7 NES

Biological processes related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.35 KIT NES PAX5 POU5F1 TNFRSF8
2 positive regulation of tumor necrosis factor biosynthetic process GO:0042535 8.62 SPN TNFRSF8

Molecular functions related to Malignant Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 8.62 KIT POU5F1

Sources for Malignant Leydig Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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