MCID: MLG042
MIFTS: 28

Malignant Otitis Externa

Categories: Bone diseases, Cancer diseases, Ear diseases, Oral diseases
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Aliases & Classifications for Malignant Otitis Externa

MalaCards integrated aliases for Malignant Otitis Externa:

Name: Malignant Otitis Externa 11 14 71 31 33
Pseudomonas Aeruginosa Osteomyelitis of the Temporal Bone 33
Necrotising Otitis Externa 33

Classifications:



External Ids:

Disease Ontology 11 DOID:10516
ICD9CM 34 380.14
SNOMED-CT 68 194206006
ICD10 31 H60.2
ICD11 33 984580942
UMLS 71 C0155395

Summaries for Malignant Otitis Externa

Disease Ontology: 11 An otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

MalaCards based summary: Malignant Otitis Externa, also known as pseudomonas aeruginosa osteomyelitis of the temporal bone, is related to cellulitis and mucormycosis. An important gene associated with Malignant Otitis Externa is CRP (C-Reactive Protein), and among its related pathways/superpathways is Signal Transduction. The drugs Anti-Infective Agents and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin.

Related Diseases for Malignant Otitis Externa

Diseases in the Otitis Externa family:

Malignant Otitis Externa

Diseases related to Malignant Otitis Externa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)
# Related Disease Score Top Affiliating Genes
1 cellulitis 30.4 INS CRP
2 mucormycosis 30.4 INS CRP
3 diabetes mellitus, ketosis-prone 30.4 INS CRP
4 otitis externa 11.2
5 osteomyelitis 10.8
6 bell's palsy 10.7
7 otorrhea 10.6
8 facial paralysis 10.5
9 acquired immunodeficiency syndrome 10.4
10 immune deficiency disease 10.3
11 papillon-lefevre syndrome 10.3
12 human immunodeficiency virus type 1 10.3
13 aspergillosis 10.3
14 cranial nerve palsy 10.3
15 cholesteatoma of middle ear 10.3
16 silent myocardial infarction 10.2 INS CRP
17 cavernous sinus thrombosis 10.2 INS CRP
18 neurogenic arthropathy 10.2 INS CRP
19 uvulitis 10.2 INS CRP
20 critical illness polyneuropathy 10.2 INS CRP
21 intracranial sinus thrombosis 10.2 INS CRP
22 balanitis 10.2 INS CRP
23 orbital cellulitis 10.2 INS CRP
24 acute orbital inflammation 10.2 INS CRP
25 renal artery disease 10.2 INS CRP
26 mediastinitis 10.2 INS CRP
27 inflammatory and toxic neuropathy 10.2 INS CRP
28 generalized atherosclerosis 10.2 INS CRP
29 paralytic ileus 10.2 INS CRP
30 marasmus 10.2 INS CRP
31 neurotic disorder 10.2 INS CRP
32 otitis media 10.2
33 type 1 diabetes mellitus 10.2
34 nasopharyngeal carcinoma 10.2
35 multiple cranial nerve palsy 10.2
36 squamous cell carcinoma 10.2
37 chronic kidney disease 10.2
38 candida glabrata 10.2
39 sphenoid sinusitis 10.2 TFF3 CRP
40 hernia, hiatus 10.2 INS CRP
41 supine hypotensive syndrome 10.2 INS CRP
42 kwashiorkor 10.2 INS CRP
43 asphyxia neonatorum 10.2 INS CRP
44 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.2 INS CRP
45 hemorrhoid 10.2 INS CRP
46 duodenitis 10.2 INS CRP
47 compartment syndrome 10.2 INS CRP
48 diastolic heart failure 10.2 INS CRP
49 skin tag 10.2 INS CRP
50 aortic atherosclerosis 10.2 INS CRP

Graphical network of the top 20 diseases related to Malignant Otitis Externa:



Diseases related to Malignant Otitis Externa

Symptoms & Phenotypes for Malignant Otitis Externa

Drugs & Therapeutics for Malignant Otitis Externa

Drugs for Malignant Otitis Externa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents
2 Anti-Bacterial Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicentre Prospective Study to Improve Outcomes of Necrotising Otitis Externa in the UK Recruiting NCT04950985

Search NIH Clinical Center for Malignant Otitis Externa

Genetic Tests for Malignant Otitis Externa

Anatomical Context for Malignant Otitis Externa

Organs/tissues related to Malignant Otitis Externa:

MalaCards : Bone, Bone Marrow, Skin, Eye

Publications for Malignant Otitis Externa

Articles related to Malignant Otitis Externa:

(show top 50) (show all 295)
# Title Authors PMID Year
1
Exploring theories for the exponential 16-year rise in incidence of necrotising otitis externa in England. 62
35000633 2022
2
Necrotising otitis externa: the increasing financial burden on the National Health Service. 62
34753526 2022
3
Intractable otitis media - Pathogenesis and treatment of Eosinophilic otitis media (EOM) and otitis media with Antineutrophil cytoplasmic antibody (ANCA) -associated vasculitis (OMAAV). 62
35934599 2022
4
Modification of bacterial cell membrane dynamics and morphology upon exposure to sub inhibitory concentrations of ciprofloxacin. 62
35461827 2022
5
Improving outcomes in necrotising otitis externa, telephone clinics, and topical pimecrolimus for chronic eczematous external otitis. 62
35788235 2022
6
Emerging themes in necrotising otitis externa: a scoping review of the literature from 2011 to 2020 and recommendations for future research. 62
34666847 2022
7
Necrotising otitis externa and how to reduce length of hospital stay: a complete audit cycle of 77 hospital admissions. 62
34674778 2022
8
Characteristics, management and outcome of a large necrotising otitis externa case series: need for standardised case definition. 62
35042578 2022
9
A Case of Collet-Sicard Syndrome Caused by Otitis Externa. 62
36035057 2022
10
A 10-year review of malignant otitis externa: a new insight. 62
34226993 2022
11
A Rare Case of Streptococcus Pneumoniae Causing Malignant Otitis Externa Complicated by Skull Base Osteomyelitis. 62
35812551 2022
12
Retrospective analysis of outcomes of outpatient parenteral antimicrobial therapy (OPAT) for necrotising otitis externa. 62
35556187 2022
13
Necrotising otitis externa, turbinate surgery, tonsillotomy, and care of octogenarian head and neck cancer patients. 62
35510489 2022
14
Necrotising otitis externa antibiotic therapy complications: A retrospective cohort analysis. 62
35194951 2022
15
Patients' experience of necrotising otitis externa: a qualitative study. 62
35343410 2022
16
Malignant otitis externa presenting cerebral infarction from pseudoaneurysm: A case report and a review of the literature. 62
35223001 2022
17
A Case of Adult Clival Osteomyelitis. 62
35608025 2022
18
A Different Era for Malignant Otitis Externa: The Non-Diabetic and Non-Immunocompromised Patients. 62
35193841 2022
19
Necrotising Otitis Externa: A Review of Imaging Modalities. 62
34966623 2021
20
Malignant Otitis Externa in a 20-Year-Old Male Patient With Erdheim-Chester Disease: A Case Report. 62
35047310 2021
21
Skull Base Fungal Osteomyelitis: A Case Report and Review of the Literature. 62
32584614 2021
22
Emerging themes in necrotising otitis externa: a scoping review of the literature 2011-2020 and recommendations for future research. 62
34823614 2021
23
Synchronous Occurrence of Bilateral Malignant Otitis Externa: Report of a Rare Case. 62
32456405 2021
24
Necrotising Otitis Externa - is poor outcome predictable? The application of a diagnosis-based scoring system in patients with skull base osteomyelitis. 62
34839843 2021
25
Recurrent endometrial carcinoma metastasis to the temporal bone and skull base. 62
34448403 2021
26
Necrotising otitis externa: a serious condition becoming more frequently encountered. 62
35317869 2021
27
Necrotising otitis externa: A serious condition becoming more frequently encountered. 62
34670634 2021
28
Hyperbaric oxygen therapy in malignant otitis externa: A systematic review of the literature. 62
34632343 2021
29
Predictive value of radiologic studies for malignant otitis externa: a systematic review and meta-analysis. 62
34799270 2021
30
Examining the utility of nuclear medicine imaging in the diagnosis and management of necrotising otitis externa. 62
33966334 2021
31
Lemierre's Syndrome Due to Malignant Otitis Externa: Imaging Studies Revealed Its Systemic Dissemination. 62
34617899 2021
32
Extra-auricular lesions of proliferative and necrotizing otitis externa in three kittens. 62
33961315 2021
33
Denosumab and bisphosphonate associated bilateral osteonecrosis of the external auditory canal. 62
34130974 2021
34
A Unique Case of Malignant Otitis Externa. 62
31565987 2021
35
Prognosticating patients with necrotising otitis externa based on response to treatment. 62
33682472 2021
36
Malignant otitis externa: An updated review. 62
33429178 2021
37
Necrotising otitis externa: A single centre experience. 62
33505446 2021
38
Beware of covert enemies: Candida orthopsilosis malignant otitis externa with base of the skull osteomyelitis, a case report and review of literature. 62
34094863 2021
39
A Case Series of Malignant Otitis Externa Mimicking Malignancy. 62
33855957 2021
40
Mycotic aortic aneurysm in a debilitated patient with compromised immunity; beware of Candida! 62
34925475 2021
41
Malignant Otitis Externa: How to Monitor the Disease in Outcome Estimation? 62
33828886 2021
42
Clinical profiling and management outcome of atypical skull base osteomyelitis. 62
31818143 2020
43
Facial nerve paralysis in malignant otitis externa: comparison of the clinical and paraclinical findings. 62
32852248 2020
44
What is the Best Test for Diagnosis and Monitoring Treatment Response in Malignant Otitis Externa? 62
32159853 2020
45
Single Application Cold-Chain Independent Drug Delivery System for Outer Ear Infections. 62
33299928 2020
46
Malignant otitis externa with subsequent internal jugular vein thrombosis and hypoglossal palsy: a report and review of literature. 62
32884563 2020
47
Thirty-Day Readmission and Prolonged Length of Stay in Malignant Otitis Externa. 62
31758583 2020
48
An emergency medicine-focused review of malignant otitis externa. 62
32505469 2020
49
Meta-analysis does not support routine traditional nuclear medicine studies for malignant otitis. 62
31750969 2020
50
A retrospective review and multi-specialty, evidence-based guideline for the management of necrotising otitis externa. 62
32498757 2020

Variations for Malignant Otitis Externa

Expression for Malignant Otitis Externa

Search GEO for disease gene expression data for Malignant Otitis Externa.

Pathways for Malignant Otitis Externa

Pathways related to Malignant Otitis Externa according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 12.51 WHAMM TFF3 RALGDS MYL9 INS ARHGAP19

GO Terms for Malignant Otitis Externa

Sources for Malignant Otitis Externa

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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