MCID: MLG042
MIFTS: 29

Malignant Otitis Externa

Categories: Ear diseases

Aliases & Classifications for Malignant Otitis Externa

MalaCards integrated aliases for Malignant Otitis Externa:

Name: Malignant Otitis Externa 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:10516
ICD10 33 H60.2 H60.20
ICD9CM 35 380.14
SNOMED-CT 68 94146005
UMLS 73 C0155395

Summaries for Malignant Otitis Externa

Disease Ontology : 12 An otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

MalaCards based summary : Malignant Otitis Externa is related to otitis externa and osteomyelitis. An important gene associated with Malignant Otitis Externa is CRP (C-Reactive Protein), and among its related pathways/superpathways are Selenium Micronutrient Network and FOXA2 and FOXA3 transcription factor networks. Affiliated tissues include bone, kidney and liver.

Related Diseases for Malignant Otitis Externa

Diseases in the Otitis Externa family:

Malignant Otitis Externa

Diseases related to Malignant Otitis Externa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 otitis externa 11.1
2 osteomyelitis 10.5
3 squamous cell carcinoma 10.2
4 immunoglobulin alpha deficiency 10.1
5 ecthyma 10.1
6 optic neuritis 10.1
7 neuritis 10.1
8 hypertrichosis 10.1
9 pneumonia 10.1
10 mucormycosis 10.1
11 candida glabrata 10.1
12 burns 10.0 INS CRP
13 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.0 INS CRP
14 acute insulin response 10.0 INS CRP
15 prediabetes syndrome 10.0 INS CRP
16 apnea, obstructive sleep 10.0 INS CRP
17 sleep disorder 10.0 INS CRP
18 anovulation 10.0 INS CRP
19 pancreas disease 10.0 INS CRP
20 inherited metabolic disorder 10.0 INS CRP
21 sleep apnea 10.0 INS CRP
22 uremia 10.0 INS CRP
23 overnutrition 10.0 INS CRP
24 hyperuricemia 10.0 INS CRP
25 arteries, anomalies of 10.0 INS CRP
26 glucose metabolism disease 10.0 INS CRP
27 lipid metabolism disorder 10.0 INS CRP
28 morbid obesity 10.0 INS CRP
29 proteasome-associated autoinflammatory syndrome 1 10.0 INS CRP
30 urinary system disease 10.0 INS CRP
31 acquired metabolic disease 10.0 INS CRP
32 atherosclerosis susceptibility 10.0 INS CRP
33 glucose intolerance 10.0 INS CRP
34 nonalcoholic fatty liver disease 10.0 CRP INS
35 nonalcoholic steatohepatitis 10.0 INS F2
36 arteriosclerosis 10.0 CRP INS
37 nervous system disease 10.0 CRP INS
38 coronary heart disease 1 10.0 CRP INS
39 maturity-onset diabetes of the young 9.9 CRP INS
40 maturity-onset diabetes of the young, type 1 9.9 CRP INS
41 chronic thromboembolic pulmonary hypertension 9.9 F2 CRP
42 abdominal tuberculosis 9.9 F2 CRP
43 hypercholesterolemia, familial 9.9 CRP INS
44 blue toe syndrome 9.9 F2 CRP
45 ischemic neuropathy 9.9 F2 CRP
46 peripheral vertigo 9.9 F2 CRP
47 endocardium disease 9.9 F2 CRP
48 analbuminemia 9.9 F2 CRP
49 arteritic anterior ischemic optic neuropathy 9.9 F2 CRP
50 venous insufficiency 9.9 F2 CRP

Graphical network of the top 20 diseases related to Malignant Otitis Externa:



Diseases related to Malignant Otitis Externa

Symptoms & Phenotypes for Malignant Otitis Externa

Drugs & Therapeutics for Malignant Otitis Externa

Search Clinical Trials , NIH Clinical Center for Malignant Otitis Externa

Genetic Tests for Malignant Otitis Externa

Anatomical Context for Malignant Otitis Externa

MalaCards organs/tissues related to Malignant Otitis Externa:

41
Bone, Kidney, Liver, Heart, Pancreas

Publications for Malignant Otitis Externa

Articles related to Malignant Otitis Externa:

(show top 50) (show all 103)
# Title Authors Year
1
Malignant Otitis Externa Outcomes: A Study of the University HealthSystem Consortium Database. ( 29962250 )
2018
2
Advanced Imaging Techniques in Skull Base Osteomyelitis Due to Malignant Otitis Externa. ( 29416952 )
2018
3
The Role of Surgical Debridement in Cases of Refractory Malignant Otitis Externa. ( 30464914 )
2018
4
Malignant Otitis Externa: A Retrospective Analysis and Treatment Outcomes. ( 30197809 )
2018
5
Skull base osteomyelitis secondary to malignant otitis externa mimicking advanced nasopharyngeal cancer: MR imaging features at initial presentation. ( 28483146 )
2017
6
The treatment of pseudoaneurysms with flow diverters after malignant otitis externa. ( 28992722 )
2017
7
Is malignant otitis externa on the increase? A retrospective review of cases. ( 28231368 )
2017
8
Fungal malignant otitis externa. ( 28348261 )
2017
9
Recurrent malignant otitis externa with multiple cranial nerve involvement: A case report. ( 29648753 )
2016
10
Malignant otitis externa hospitalizations: Analysis of patient characteristics. ( 27882553 )
2016
11
Chorda tympani schwannoma: one new case revealed during malignant otitis externa and review of the literature. ( 26952150 )
2016
12
Scedosporium apiospermum: a rare cause of malignant otitis externa. ( 27613266 )
2016
13
Malignant otitis externa in a healthy non-diabetic patient. ( 26233245 )
2015
14
Malignant Otitis Externa - A Retrospective Study of 15 Patients Treated in a Tertiary Healthcare Center. ( 26223723 )
2015
15
Hypoglossal paresis as the only complication of malignant otitis externa. ( 26601558 )
2015
16
Necrotising (malignant) otitis externa in the UK: a growing problem. Review of five cases and analysis of national Hospital Episode Statistics trends. ( 25990028 )
2015
17
Malignant otitis externa. ( 25923266 )
2015
18
Malignant Otitis Externa: A Novel Stratification Protocol for Predicting Treatment Outcomes. ( 26375971 )
2015
19
Lessons learnt from the diagnosis and antimicrobial management of necrotising (malignant) otitis externa: our experience in a tertiary referral centre. ( 25090807 )
2014
20
Temporal bone osteomyelitis: the relationship with malignant otitis externa, the diagnostic dilemma, and changing trends. ( 24963511 )
2014
21
Cervical internal carotid Artery pseudoaneurysm complicating malignant otitis externa: First case report. ( 25124769 )
2014
22
Response to "management and outcomes in patients affected by malignant otitis externa". ( 25344096 )
2014
23
Malignant Otitis Externa: Evolving Pathogens and Implications for Diagnosis and Treatment. ( 24675790 )
2014
24
Management and outcomes in patients affected by malignant otitis externa. ( 25344095 )
2014
25
Fungal malignant otitis externa with facial nerve palsy: tissue biopsy AIDS diagnosis. ( 24649388 )
2014
26
What are the criteria for terminating treatment for necrotizing (malignant) otitis externa? ( 24105671 )
2014
27
Single photon emission computed tomography/computed tomography for malignant otitis externa: lesion not shown on planar image. ( 23313120 )
2013
28
Hyperbaric oxygen as an adjuvant treatment for malignant otitis externa. ( 23728650 )
2013
29
Synchronous malignant otitis externa and squamous cell carcinoma of the external auditory canal. ( 24194996 )
2013
30
Malignant otitis externa: an Asian perspective on treatment outcomes and prognostic factors. ( 23558287 )
2013
31
A case of orbital apex syndrome in a patient with malignant otitis externa. ( 23894912 )
2013
32
Is laterality of malignant otitis externa related to handedness? ( 23669376 )
2013
33
Malignant otitis externa: an Australian case series. ( 22032882 )
2012
34
Malignant otitis externa. ( 23147298 )
2012
35
A rare and sinister variant of a common ailment: Fungal malignant otitis externa. ( 24960790 )
2012
36
Fungal malignant otitis externa: pitfalls, diagnosis, and treatment. ( 22664903 )
2012
37
Single photon emission computed tomography/computed tomography of the skull in malignant otitis externa. ( 21764178 )
2012
38
Recurrent malignant otitis externa: management and outcome. ( 21833561 )
2012
39
A rare case of bilateral malignant otitis externa and osteomyelitis with lower cranial nerve sequelae. ( 22696730 )
2011
40
Skull based osteomyelitis due to postsurgery malignant otitis externa presenting as stroke. ( 22696765 )
2011
41
Malignant otitis externa caused by Aspergillus fumigatus: a case report. ( 21765381 )
2011
42
Malignant otitis externa: experience with hyperbaric oxygen therapy. ( 21948502 )
2011
43
Malignant otitis externa with skull base osteomyelitis. ( 24950586 )
2011
44
Malignant otitis externa (MOE) causing cerebral abscess and facial nerve palsy. ( 20629077 )
2010
45
Malignant otitis externa: experience with hyperbaric oxygen therapy. ( 23111931 )
2010
46
Malignant otitis externa. ( 20228437 )
2010
47
Malignant otitis externa: experience with hyperbaric oxygen therapy. ( 23111934 )
2010
48
Atypical presentations of malignant otitis externa. ( 20193102 )
2010
49
Malignant otitis externa: case series. ( 20388240 )
2010
50
Temporal bone osteomyelitis and temporoparietal abscess secondary to malignant otitis externa. ( 19371455 )
2009

Variations for Malignant Otitis Externa

Expression for Malignant Otitis Externa

Search GEO for disease gene expression data for Malignant Otitis Externa.

Pathways for Malignant Otitis Externa

Pathways related to Malignant Otitis Externa according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.13 CRP F2 INS
2 10.6 F2 INS

GO Terms for Malignant Otitis Externa

Cellular components related to Malignant Otitis Externa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum lumen GO:0005788 9.16 F2 INS
2 extracellular space GO:0005615 9.13 CRP F2 INS
3 Golgi lumen GO:0005796 8.62 F2 INS

Biological processes related to Malignant Otitis Externa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 F2 INS
2 ER to Golgi vesicle-mediated transport GO:0006888 9.4 F2 INS
3 positive regulation of cell growth GO:0030307 9.37 F2 INS
4 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.32 F2 INS
5 negative regulation of proteolysis GO:0045861 9.26 F2 INS
6 positive regulation of protein localization to nucleus GO:1900182 9.16 F2 INS
7 negative regulation of blood vessel diameter GO:0097756 8.96 CRP INS
8 acute-phase response GO:0006953 8.8 CRP F2 INS

Sources for Malignant Otitis Externa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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