Malignant Otitis Externa disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Disease Ontology: ¹¹ An otitis externa which involves infection of the external ear that has spread to involve the skull bone containing part of the ear canal, the middle ear, and the inner ear. It is caused by the bacteria Pseudomonas. This is common in people with weakened immune systems and in older people with diabetes.

MalaCards based summary: Malignant Otitis Externa, also known as pseudomonas aeruginosa osteomyelitis of the temporal bone, is related to cellulitis and mucormycosis. An important gene associated with Malignant Otitis Externa is CRP (C-Reactive Protein), and among its related pathways/superpathways is Signal Transduction. The drugs Anti-Infective Agents and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and skin.

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Related Diseases for Malignant Otitis Externa

Diseases in the Otitis Externa family:

Malignant Otitis Externa

Diseases related to Malignant Otitis Externa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 159)

#	Related Disease	Score	Top Affiliating Genes
1	cellulitis	30.4	INS CRP
2	mucormycosis	30.4	INS CRP
3	diabetes mellitus, ketosis-prone	30.4	INS CRP
4	otitis externa	11.2
5	osteomyelitis	10.8
6	bell's palsy	10.7
7	otorrhea	10.6
8	facial paralysis	10.5
9	acquired immunodeficiency syndrome	10.4
10	immune deficiency disease	10.3
11	papillon-lefevre syndrome	10.3
12	human immunodeficiency virus type 1	10.3
13	aspergillosis	10.3
14	cranial nerve palsy	10.3
15	cholesteatoma of middle ear	10.3
16	silent myocardial infarction	10.2	INS CRP
17	cavernous sinus thrombosis	10.2	INS CRP
18	neurogenic arthropathy	10.2	INS CRP
19	uvulitis	10.2	INS CRP
20	critical illness polyneuropathy	10.2	INS CRP
21	intracranial sinus thrombosis	10.2	INS CRP
22	balanitis	10.2	INS CRP
23	orbital cellulitis	10.2	INS CRP
24	acute orbital inflammation	10.2	INS CRP
25	renal artery disease	10.2	INS CRP
26	mediastinitis	10.2	INS CRP
27	inflammatory and toxic neuropathy	10.2	INS CRP
28	generalized atherosclerosis	10.2	INS CRP
29	paralytic ileus	10.2	INS CRP
30	marasmus	10.2	INS CRP
31	neurotic disorder	10.2	INS CRP
32	otitis media	10.2
33	type 1 diabetes mellitus	10.2
34	nasopharyngeal carcinoma	10.2
35	multiple cranial nerve palsy	10.2
36	squamous cell carcinoma	10.2
37	chronic kidney disease	10.2
38	candida glabrata	10.2
39	sphenoid sinusitis	10.2	TFF3 CRP
40	hernia, hiatus	10.2	INS CRP
41	supine hypotensive syndrome	10.2	INS CRP
42	kwashiorkor	10.2	INS CRP
43	asphyxia neonatorum	10.2	INS CRP
44	abdominal obesity-metabolic syndrome quantitative trait locus 2	10.2	INS CRP
45	hemorrhoid	10.2	INS CRP
46	duodenitis	10.2	INS CRP
47	compartment syndrome	10.2	INS CRP
48	diastolic heart failure	10.2	INS CRP
49	skin tag	10.2	INS CRP
50	aortic atherosclerosis	10.2	INS CRP

Graphical network of the top 20 diseases related to Malignant Otitis Externa:

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Symptoms & Phenotypes for Malignant Otitis Externa

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Drugs & Therapeutics for Malignant Otitis Externa

Drugs for Malignant Otitis Externa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#	Name	Status	Phase	Clinical Trials	Cas Number	PubChem Id
1	Anti-Infective Agents
2	Anti-Bacterial Agents

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Multicentre Prospective Study to Improve Outcomes of Necrotising Otitis Externa in the UK	Recruiting	NCT04950985

Search NIH Clinical Center for Malignant Otitis Externa

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Genetic Tests for Malignant Otitis Externa

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Anatomical Context for Malignant Otitis Externa

Organs/tissues related to Malignant Otitis Externa:

MalaCards : Bone, Bone Marrow, Skin, Eye

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Publications for Malignant Otitis Externa

Articles related to Malignant Otitis Externa:

(show top 50) (show all 295)

#	Title	Authors	PMID	Year
1	Exploring theories for the exponential 16-year rise in incidence of necrotising otitis externa in England. ⁶²	Linton S...Stapleton E	35000633	2022
2	Necrotising otitis externa: the increasing financial burden on the National Health Service. ⁶²	Godbehere J...Watson GJ	34753526	2022
3	Intractable otitis media - Pathogenesis and treatment of Eosinophilic otitis media (EOM) and otitis media with Antineutrophil cytoplasmic antibody (ANCA) -associated vasculitis (OMAAV). ⁶²	Yoshida N	35934599	2022
4	Modification of bacterial cell membrane dynamics and morphology upon exposure to sub inhibitory concentrations of ciprofloxacin. ⁶²	Ponmalar II...Basu JK	35461827	2022
5	Improving outcomes in necrotising otitis externa, telephone clinics, and topical pimecrolimus for chronic eczematous external otitis. ⁶²	Fishman J...Fisher E	35788235	2022
6	Emerging themes in necrotising otitis externa: a scoping review of the literature from 2011 to 2020 and recommendations for future research. ⁶²	Stapleton E...Watson G	34666847	2022
7	Necrotising otitis externa and how to reduce length of hospital stay: a complete audit cycle of 77 hospital admissions. ⁶²	Mohammed H...Yates P	34674778	2022
8	Characteristics, management and outcome of a large necrotising otitis externa case series: need for standardised case definition. ⁶²	Hodgson SH...Andersson MI	35042578	2022
9	A Case of Collet-Sicard Syndrome Caused by Otitis Externa. ⁶²	Bonda S...Asad S	36035057	2022
10	A 10-year review of malignant otitis externa: a new insight. ⁶²	Kamalden TMIT...Misron K	34226993	2022
11	A Rare Case of Streptococcus Pneumoniae Causing Malignant Otitis Externa Complicated by Skull Base Osteomyelitis. ⁶²	Wahbah Makhoul G...Mobarakai N	35812551	2022
12	Retrospective analysis of outcomes of outpatient parenteral antimicrobial therapy (OPAT) for necrotising otitis externa. ⁶²	Durojaiye OC...Kritsotakis EI	35556187	2022
13	Necrotising otitis externa, turbinate surgery, tonsillotomy, and care of octogenarian head and neck cancer patients. ⁶²	Fisher EW...Fishman J	35510489	2022
14	Necrotising otitis externa antibiotic therapy complications: A retrospective cohort analysis. ⁶²	Ijaz A...Watson G	35194951	2022
15	Patients' experience of necrotising otitis externa: a qualitative study. ⁶²	Owen E...Stapleton E	35343410	2022
16	Malignant otitis externa presenting cerebral infarction from pseudoaneurysm: A case report and a review of the literature. ⁶²	Koshiba Y...Katori Y	35223001	2022
17	A Case of Adult Clival Osteomyelitis. ⁶²	Kayode-Ajala F...Farrer W	35608025	2022
18	A Different Era for Malignant Otitis Externa: The Non-Diabetic and Non-Immunocompromised Patients. ⁶²	Sideris G...Nikolopoulos T	35193841	2022
19	Necrotising Otitis Externa: A Review of Imaging Modalities. ⁶²	Khan HA	34966623	2021
20	Malignant Otitis Externa in a 20-Year-Old Male Patient With Erdheim-Chester Disease: A Case Report. ⁶²	Alarimah YGS...Aldajani NF	35047310	2021
21	Skull Base Fungal Osteomyelitis: A Case Report and Review of the Literature. ⁶²	Di Lullo AM...Cavaliere M	32584614	2021
22	Emerging themes in necrotising otitis externa: a scoping review of the literature 2011-2020 and recommendations for future research. ⁶²	Stapleton E...Watson G	34823614	2021
23	Synchronous Occurrence of Bilateral Malignant Otitis Externa: Report of a Rare Case. ⁶²	Lamry NA...Salim R	32456405	2021
24	Necrotising Otitis Externa - is poor outcome predictable? The application of a diagnosis-based scoring system in patients with skull base osteomyelitis. ⁶²	Rojoa DM...Rea PA	34839843	2021
25	Recurrent endometrial carcinoma metastasis to the temporal bone and skull base. ⁶²	Wong B...Patil S	34448403	2021
26	Necrotising otitis externa: a serious condition becoming more frequently encountered. ⁶²	Eweiss AZ...Jama G	35317869	2021
27	Necrotising otitis externa: A serious condition becoming more frequently encountered. ⁶²	Eweiss AZ...Jama G	34670634	2021
28	Hyperbaric oxygen therapy in malignant otitis externa: A systematic review of the literature. ⁶²	Byun YJ...Lambert PR	34632343	2021
29	Predictive value of radiologic studies for malignant otitis externa: a systematic review and meta-analysis. ⁶²	Kim DH...Hwang SH	34799270	2021
30	Examining the utility of nuclear medicine imaging in the diagnosis and management of necrotising otitis externa. ⁶²	Ringrose T...Pringle MB	33966334	2021
31	Lemierre's Syndrome Due to Malignant Otitis Externa: Imaging Studies Revealed Its Systemic Dissemination. ⁶²	Ogi M...Horii A	34617899	2021
32	Extra-auricular lesions of proliferative and necrotizing otitis externa in three kittens. ⁶²	Panzuti P...Pin D	33961315	2021
33	Denosumab and bisphosphonate associated bilateral osteonecrosis of the external auditory canal. ⁶²	True HD...Smith JA	34130974	2021
34	A Unique Case of Malignant Otitis Externa. ⁶²	Horani S...Mitchell RB	31565987	2021
35	Prognosticating patients with necrotising otitis externa based on response to treatment. ⁶²	Cho WS...Fergie N	33682472	2021
36	Malignant otitis externa: An updated review. ⁶²	Trevino Gonzalez JL...Hernandez de Leon JE	33429178	2021
37	Necrotising otitis externa: A single centre experience. ⁶²	Hasnaoui M...Mighri K	33505446	2021
38	Beware of covert enemies: Candida orthopsilosis malignant otitis externa with base of the skull osteomyelitis, a case report and review of literature. ⁶²	Koleri J...Abdelhadi H	34094863	2021
39	A Case Series of Malignant Otitis Externa Mimicking Malignancy. ⁶²	Selvamalar V...Daud MK	33855957	2021
40	Mycotic aortic aneurysm in a debilitated patient with compromised immunity; beware of Candida! ⁶²	Gunawardena T...Wijeyaratne M	34925475	2021
41	Malignant Otitis Externa: How to Monitor the Disease in Outcome Estimation? ⁶²	Yigider AP...Yigit O	33828886	2021
42	Clinical profiling and management outcome of atypical skull base osteomyelitis. ⁶²	Singh U...Chinnusamy R	31818143	2020
43	Facial nerve paralysis in malignant otitis externa: comparison of the clinical and paraclinical findings. ⁶²	Dabiri S...Saedi E	32852248	2020
44	What is the Best Test for Diagnosis and Monitoring Treatment Response in Malignant Otitis Externa? ⁶²	Sturm JJ...Lalwani AK	32159853	2020
45	Single Application Cold-Chain Independent Drug Delivery System for Outer Ear Infections. ⁶²	Serban BA...Serban MA	33299928	2020
46	Malignant otitis externa with subsequent internal jugular vein thrombosis and hypoglossal palsy: a report and review of literature. ⁶²	Devaraja K...Nayak DR	32884563	2020
47	Thirty-Day Readmission and Prolonged Length of Stay in Malignant Otitis Externa. ⁶²	Schwam ZG...Cosetti MK	31758583	2020
48	An emergency medicine-focused review of malignant otitis externa. ⁶²	Long DA...Long B	32505469	2020
49	Meta-analysis does not support routine traditional nuclear medicine studies for malignant otitis. ⁶²	Moss WJ...Chan JYK	31750969	2020
50	A retrospective review and multi-specialty, evidence-based guideline for the management of necrotising otitis externa. ⁶²	Hopkins ME...Sutherland R	32498757	2020

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Genes for Malignant Otitis Externa

Genes related to Malignant Otitis Externa (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CRP	C-Reactive Protein	Protein Coding	4.93	DISEASES inferred ¹⁴
2	INS	Insulin	Protein Coding	4.33	DISEASES inferred ¹⁴
3	TFF3	Trefoil Factor 3	Protein Coding	4.26	DISEASES inferred ¹⁴
4	ARHGAP19	Rho GTPase Activating Protein 19	Protein Coding	4.25	DISEASES inferred ¹⁴
5	RALGDS	Ral Guanine Nucleotide Dissociation Stimulator	Protein Coding	4.2	DISEASES inferred ¹⁴
6	WHAMM	WASP Homolog Associated With Actin, Golgi Membranes And Microtubules	Protein Coding	4.09	DISEASES inferred ¹⁴
7	MYL9	Myosin Light Chain 9	Protein Coding	4.08	DISEASES inferred ¹⁴
8	METTL7A	Methyltransferase Like 7A	Protein Coding	4	DISEASES inferred ¹⁴
9	SYNE4	Spectrin Repeat Containing Nuclear Envelope Family Member 4	Protein Coding	3.98	DISEASES inferred ¹⁴

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Variations for Malignant Otitis Externa

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Expression for Malignant Otitis Externa

Search GEO for disease gene expression data for Malignant Otitis Externa.

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Pathways for Malignant Otitis Externa

Pathways related to Malignant Otitis Externa according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Signal Transduction ⁶⁶	12.51	WHAMM TFF3 RALGDS MYL9 INS ARHGAP19

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GO Terms for Malignant Otitis Externa

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Sources for Malignant Otitis Externa

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 24-Oct-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MLG042 MIFTS: 28	Malignant Otitis Externa Categories: Bone diseases, Cancer diseases, Ear diseases, Oral diseases	Data Licensing For inquiries, contact: [email protected]
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