MCID: MLG053
MIFTS: 30

Malignant Ovarian Brenner Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases
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Aliases & Classifications for Malignant Ovarian Brenner Tumor

MalaCards integrated aliases for Malignant Ovarian Brenner Tumor:

Name: Malignant Ovarian Brenner Tumor 11 14 16
Malignant Brenner Tumor 71

Classifications:



External Ids:

Disease Ontology 11 DOID:4217
MeSH 43 D001948
NCIt 49 C4270
SNOMED-CT 68 42194009
UMLS 71 C0334495

Summaries for Malignant Ovarian Brenner Tumor

Disease Ontology: 11 A malignant ovarian surface epithelial-stromal neoplasm that has material basis in the surface epithelium of the ovary.

MalaCards based summary: Malignant Ovarian Brenner Tumor, also known as malignant brenner tumor, is related to ovarian brenner tumor and endometrial cancer. An important gene associated with Malignant Ovarian Brenner Tumor is PTHLH (Parathyroid Hormone Like Hormone), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and Vitamin D receptor pathway. The drugs Carboplatin and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include ovary and endothelial, and related phenotype is skeleton.

Related Diseases for Malignant Ovarian Brenner Tumor

Diseases in the Ovarian Brenner Tumor family:

Malignant Ovarian Brenner Tumor

Diseases related to Malignant Ovarian Brenner Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 ovarian brenner tumor 10.4
2 endometrial cancer 10.1
3 cystadenoma 10.1
4 childhood ovarian dysgerminoma 10.0 PTHLH PTH
5 childhood ovarian germ cell tumor 10.0 PTHLH PTH
6 dysgerminoma of ovary 10.0 PTHLH PTH
7 ovarian small cell carcinoma 10.0 PTHLH PTH
8 invasive malignant thymoma 10.0 PTHLH PTH
9 eiken syndrome 10.0 PTHLH PTH
10 failure of tooth eruption, primary 10.0 PTHLH PTH
11 sclerosing hepatic carcinoma 10.0 PTHLH PTH
12 pseudopseudohypoparathyroidism 10.0 PTHLH PTH
13 metaphyseal chondrodysplasia, jansen type 10.0 PTHLH PTH
14 pseudohypoparathyroidism, type ia 10.0 PTHLH PTH
15 acrodysostosis 10.0 PTHLH PTH
16 phosphorus metabolism disease 10.0 PTHLH PTH
17 osseous heteroplasia, progressive 10.0 PTHLH PTH
18 pseudohypoparathyroidism, type ib 10.0 PTHLH PTH
19 metaphyseal dysplasia 10.0 PTHLH PTH
20 osteoblastoma 10.0 TNFSF11 PTH
21 van buchem disease 9.9 TNFSF11 PTH
22 chondroblastoma 9.9 TNFSF11 PTHLH
23 hyperprolactinemia 9.9 PTHLH PTH
24 connective tissue benign neoplasm 9.9 TNFSF11 PTH
25 hypophosphatemia 9.9 PTHLH PTH
26 sclerosteosis 9.9 TNFSF11 PTH
27 cleidocranial dysplasia 1 9.9 TNFSF11 PTHLH
28 thyroid gland disease 9.9 PTH CALCA
29 tetanic cataract 9.9 PTH CALCA
30 substernal goiter 9.9 PTH CALCA
31 kohler's disease 9.9 PTH CALCA
32 isthmus cancer 9.9 PTH CALCA
33 endemic goiter 9.9 PTH CALCA
34 plummer's disease 9.9 PTH CALCA
35 spondyloarthropathy 1 9.9 TNFSF11 PTH
36 nontoxic goiter 9.9 PTH CALCA
37 bursitis 9.9 PTH CALCA
38 osteitis fibrosa 9.9 PTH CALCA
39 endosteal hyperostosis, autosomal dominant 9.9 TNFSF11 PTH
40 graves disease 1 9.9 PTH CALCA
41 nerve compression syndrome 9.9 PTH CALCA
42 nodular goiter 9.8 PTH CALCA
43 thyroid gland medullary carcinoma 9.8 PTH CALCA
44 multiple endocrine neoplasia, type iia 9.8 PTH CALCA
45 multiple endocrine neoplasia 9.8 PTH CALCA
46 paget disease of bone 5, juvenile-onset 9.8 TNFSF11 CALCA
47 telangiectatic osteogenic sarcoma 9.8 TNFSF11 CALCA
48 parathyroid carcinoma 9.8 PTH CALCA
49 islet cell tumor 9.8 PTHLH CALCA
50 multinodular goiter 9.8 PTH CALCA

Graphical network of the top 20 diseases related to Malignant Ovarian Brenner Tumor:



Diseases related to Malignant Ovarian Brenner Tumor

Symptoms & Phenotypes for Malignant Ovarian Brenner Tumor

MGI Mouse Phenotypes related to Malignant Ovarian Brenner Tumor:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 skeleton MP:0005390 8.92 CALCA PTH PTHLH TNFSF11

Drugs & Therapeutics for Malignant Ovarian Brenner Tumor

Drugs for Malignant Ovarian Brenner Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904
2
Bevacizumab Approved, Investigational Phase 3 216974-75-3 135329020
3
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
4
Cisplatin Approved Phase 3 15663-27-1 2767 5702198 441203
5 Carotenoids Phase 3
6 Trace Elements Phase 3
7 Micronutrients Phase 3
8 Immunoglobulins, Intravenous Phase 3
9 Albumin-Bound Paclitaxel Phase 3
10 Immunoglobulins Phase 3
11 Antimitotic Agents Phase 3
12 Immunoglobulin G Phase 3
13 Angiogenesis Inhibitors Phase 3
14 Tubulin Modulators Phase 3
15 Antibodies, Monoclonal Phase 3
16 Antibodies Phase 3
17 Antineoplastic Agents, Immunological Phase 3
18 Immunologic Factors Phase 3
19 Endothelial Growth Factors Phase 3
20 Mitogens Phase 3
21
Iodine Approved, Investigational Phase 1, Phase 2 7553-56-2 807
22
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
23
Tannic acid Approved 1401-55-4 16129878 16129778

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Can Diet and Physical Activity Modulate Ovarian, Fallopian Tube and Primary Peritoneal Cancer Progression-Free Survival? Unknown status NCT00719303 Phase 3
2 A Phase III Clinical Trial of Bevacizumab With IV Versus IP Chemotherapy in Ovarian, Fallopian Tube and Primary Peritoneal Carcinoma Completed NCT00951496 Phase 3 Carboplatin;Cisplatin;Paclitaxel
3 A Phase II Trial of Bevacizumab With Carboplatin and Weekly Paclitaxel as First-Line Treatment in Epithelial Ovarian, Primary Peritoneal, and Fallopian Tube Carcinoma Completed NCT01097746 Phase 2 Carboplatin;Paclitaxel
4 A Randomized Phase II Induction Discontinuation Trial of Emactuzumab Following Paclitaxel and Bevacizumab in Patients With Platinum-Resistant, Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Completed NCT02923739 Phase 2 Paclitaxel
5 Phase I/II Trial of Intraperitoneal Administration of Adipose Tissue Derived Mesenchymal Stem Cells Infected With a NIS-Expressing Derivative Manufactured From a Genetically Engineered Strain of Measles Virus in Patients With Recurrent Ovarian Cancer Recruiting NCT02068794 Phase 1, Phase 2
6 A Prospective, Longitudinal Study of YKL-40 in Patients With FIGO Stage III or IV Invasive Epithelial Ovarian, Primary Peritoneal or Fallopian Tube Cancer Undergoing Primary Chemotherapy Terminated NCT00899093
7 The Effects of Moderate Exercise on Distress, Quality of Life, and Biomarkers of Angiogenesis and Chronic Stress in Ovarian Cancer Survivors - A Randomized Controlled Trial Terminated NCT03641287

Search NIH Clinical Center for Malignant Ovarian Brenner Tumor

Genetic Tests for Malignant Ovarian Brenner Tumor

Anatomical Context for Malignant Ovarian Brenner Tumor

Organs/tissues related to Malignant Ovarian Brenner Tumor:

MalaCards : Ovary, Endothelial

Publications for Malignant Ovarian Brenner Tumor

Articles related to Malignant Ovarian Brenner Tumor:

# Title Authors PMID Year
1
Coexistence of malignant ovarian Brenner tumor and borderline mucinous cystadenoma, combined with primary uterine corpus endometrioid carcinoma: A case report and literature review. 62
35782900 2022
2
Malignant ovarian Brenner tumor. A case report evaluated with (18)F-FDG PET/CT. 62
25890890 2015
3
[Chemotherapy of malignant ovarian Brenner tumors. Review of the literature apropos of 2 histological complete remissions after polychemotherapy]. 62
1292763 1992
4
The histologic features and histogenesis of malignant ovarian Brenner tumor. 62
3100186 1986
5
[Malignant ovarian Brenner tumor]. 62
865721 1977

Variations for Malignant Ovarian Brenner Tumor

Expression for Malignant Ovarian Brenner Tumor

Search GEO for disease gene expression data for Malignant Ovarian Brenner Tumor.

Pathways for Malignant Ovarian Brenner Tumor

GO Terms for Malignant Ovarian Brenner Tumor

Cellular components related to Malignant Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 TNFSF11 PTHLH PTH CALCA

Biological processes related to Malignant Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ossification GO:0001503 9.76 TNFSF11 CALCA
2 bone mineralization GO:0030282 9.73 PTHLH PTH
3 monocyte chemotaxis GO:0002548 9.71 TNFSF11 CALCA
4 cell-cell signaling GO:0007267 9.65 PTHLH PTH CALCA
5 bone resorption GO:0045453 9.62 TNFSF11 PTH
6 calcium ion homeostasis GO:0055074 9.54 TNFSF11 PTH
7 negative regulation of chondrocyte differentiation GO:0032331 9.46 PTHLH PTH
8 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.43 PTHLH PTH CALCA
9 cAMP metabolic process GO:0046058 8.92 PTHLH PTH

Molecular functions related to Malignant Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 9.26 PTHLH PTH
2 hormone activity GO:0005179 9.1 PTHLH PTH CALCA

Sources for Malignant Ovarian Brenner Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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