MCID: MLG053
MIFTS: 29

Malignant Ovarian Brenner Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Malignant Ovarian Brenner Tumor

MalaCards integrated aliases for Malignant Ovarian Brenner Tumor:

Name: Malignant Ovarian Brenner Tumor 12 15 17
Malignant Brenner Tumor 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4217
MeSH 44 D001948
NCIt 50 C4270
SNOMED-CT 67 42194009
UMLS 70 C0334495

Summaries for Malignant Ovarian Brenner Tumor

Disease Ontology : 12 A malignant ovarian surface epithelial-stromal neoplasm that has material basis in the surface epithelium of the ovary.

MalaCards based summary : Malignant Ovarian Brenner Tumor, also known as malignant brenner tumor, is related to ovarian brenner tumor and pediatric ovarian germ cell tumor. An important gene associated with Malignant Ovarian Brenner Tumor is PTHLH (Parathyroid Hormone Like Hormone), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and G alpha (s) signalling events. Affiliated tissues include ovary, testis and cervix.

Related Diseases for Malignant Ovarian Brenner Tumor

Diseases in the Ovarian Brenner Tumor family:

Malignant Ovarian Brenner Tumor

Diseases related to Malignant Ovarian Brenner Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 ovarian brenner tumor 10.4
2 pediatric ovarian germ cell tumor 10.1 PTHLH PTH
3 pediatric ovarian dysgerminoma 10.1 PTHLH PTH
4 oncogenic osteomalacia 10.0 PTHLH PTH
5 sclerosing hepatic carcinoma 10.0 PTHLH PTH
6 invasive malignant thymoma 10.0 PTHLH PTH
7 eiken syndrome 10.0 PTHLH PTH
8 metaphyseal chondrodysplasia, jansen type 10.0 PTHLH PTH
9 pseudopseudohypoparathyroidism 10.0 PTHLH PTH
10 phosphorus metabolism disease 10.0 PTHLH PTH
11 pseudohypoparathyroidism, type ia 10.0 PTHLH PTH
12 enchondromatosis, multiple, ollier type 10.0 PTHLH PTH
13 acrodysostosis 10.0 PTHLH PTH
14 osseous heteroplasia, progressive 10.0 PTHLH PTH
15 pseudohypoparathyroidism, type ib 10.0 PTHLH PTH
16 keratocystic odontogenic tumor 10.0 TNFSF11 PTHLH
17 pigmented villonodular synovitis 10.0 TNFSF11 PTHLH
18 multicentric carpotarsal osteolysis syndrome 10.0 TNFSF11 PTHLH
19 hyperprolactinemia 10.0 PTHLH PTH
20 van buchem disease 10.0 TNFSF11 PTH
21 chondroblastoma 10.0 TNFSF11 PTHLH
22 connective tissue benign neoplasm 10.0 TNFSF11 PTH
23 hypophosphatemia 9.9 PTHLH PTH
24 sclerosteosis 9.9 TNFSF11 PTH
25 bone development disease 9.9 PTHLH PTH
26 osteonecrosis 9.9 TNFSF11 PTH
27 thyroid gland disease 9.9 PTH CALCA
28 substernal goiter 9.9 PTH CALCA
29 spondyloarthropathy 1 9.9 TNFSF11 PTH
30 endemic goiter 9.9 PTH CALCA
31 osteitis fibrosa 9.9 PTH CALCA
32 suppurative thyroiditis 9.9 PTH CALCA
33 nontoxic goiter 9.9 PTH CALCA
34 graves disease 1 9.9 PTH CALCA
35 thyroid gland medullary carcinoma 9.9 PTH CALCA
36 endosteal hyperostosis, autosomal dominant 9.8 TNFSF11 PTH
37 kummell's disease 9.8 TNFSF11 CALCA
38 paget disease of bone 5, juvenile-onset 9.8 TNFSF11 CALCA
39 aneurysmal bone cysts 9.8 TNFSF11 CALCA
40 parathyroid carcinoma 9.8 PTH CALCA
41 islet cell tumor 9.8 PTHLH CALCA
42 multinodular goiter 9.8 PTH CALCA
43 multiple endocrine neoplasia, type iia 9.8 PTH CALCA
44 multiple endocrine neoplasia 9.8 PTH CALCA
45 root resorption 9.8 TNFSF11 CALCA
46 benign giant cell tumor 9.8 TNFSF11 CALCA
47 secondary hyperparathyroidism 9.8 PTH CALCA
48 fibrous dysplasia 9.8 TNFSF11 CALCA
49 cherubism 9.8 TNFSF11 CALCA
50 endocrine organ benign neoplasm 9.7 PTH CALCA

Graphical network of the top 20 diseases related to Malignant Ovarian Brenner Tumor:



Diseases related to Malignant Ovarian Brenner Tumor

Symptoms & Phenotypes for Malignant Ovarian Brenner Tumor

Drugs & Therapeutics for Malignant Ovarian Brenner Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Ovarian Brenner Tumor

Genetic Tests for Malignant Ovarian Brenner Tumor

Anatomical Context for Malignant Ovarian Brenner Tumor

MalaCards organs/tissues related to Malignant Ovarian Brenner Tumor:

40
Ovary, Testis, Cervix, Endothelial

Publications for Malignant Ovarian Brenner Tumor

Articles related to Malignant Ovarian Brenner Tumor:

(show top 50) (show all 99)
# Title Authors PMID Year
1
Recurrent urothelial carcinoma-like FGFR3 genomic alterations in malignant Brenner tumors of the ovary. 61
33077920 2020
2
Ovarian Mixed Malignant Brenner-Mucinous Tumor with Signet Ring Cells. 61
32274235 2020
3
[Malignant Brenner tumor with a functioning stroma in elderly woman: report of a case]. 61
31818078 2019
4
Malignant Brenner tumor of the ovary: Case series and review of treatment strategies. 61
30815527 2019
5
Malignant Brenner tumor: Two case reports. 61
30364765 2018
6
Malignant Brenner tumor of the ovary: Review and case report. 61
28971141 2017
7
Malignant Brenner tumor associated with a germline BRCA2 mutation. 61
28616458 2017
8
Laparoscopic treatment of Castleman's disease in a patient with a history of malignant Brenner tumor. 61
27751433 2016
9
Benign and Malignant Brenner Tumors Show an Absence of TERT Promoter Mutations That Are Commonly Present in Urothelial Carcinoma. 61
27299795 2016
10
Malignant Brenner tumors of the ovary; a population-based analysis. 61
27130406 2016
11
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer. 61
26892153 2016
12
[Oncopathological aspects of BRCA1 and BRCA2 genes inactivation in tumors of ovary, fallopian tube and pelvic peritoneum]. 61
27869446 2016
13
Malignant ovarian Brenner tumor. A case report evaluated with (18)F-FDG PET/CT. 61
25890890 2015
14
Intensive systemic chemotherapy is effective against recurrent malignant Brenner tumor of the ovary: An analysis of 10 cases within a single center. 61
25951724 2015
15
Incidence of serous tubal intraepithelial carcinoma (STIC) by algorithm classification in serous ovarian tumor associated with PAX8 expression in tubal epithelia: a study of single institution in Japan. 61
25473747 2015
16
Malignant brenner tumor of ovary. 61
24757346 2014
17
Ovarian malignant Brenner tumor in patients over 65 years of age. 61
24581217 2014
18
[Malignant Brenner tumor with very good response after chemotherapy: about a case and review of the literature]. 61
25328589 2014
19
The value of PAX8 and WT1 molecules in ovarian cancer diagnosis. 61
23529305 2013
20
Three cases of an unusual pattern of invasion in malignant Brenner tumors. 61
23202779 2013
21
Transitional cell carcinoma of the ovary is related to high-grade serous carcinoma and is distinct from malignant brenner tumor. 61
23018212 2012
22
Hypercalcemia associated with a malignant brenner tumor arising from a mature cystic teratoma. 61
23185165 2012
23
Malignant Brenner tumor of the ovary: analysis of 13 cases. 61
21796330 2012
24
Malignant Brenner tumor of the ovary with transformation to trabecular carcinoid: an immunocytochemical and electron microscopic study. 61
22123728 2012
25
Diffusion-weighted imaging of a malignant brenner tumor. 61
22450390 2012
26
Squamous cell carcinoma of the ovary arising from a mucinous cystic tumor of endocervical (müllerian) type. 61
20881861 2010
27
[Ovarian carcinoma: current diagnostic principles]. 61
20941958 2010
28
Ascitic fluid cytology in malignant Brenner tumor: a case report. 61
20715663 2010
29
A rare malignant Brenner tumor of the ovary in a 77-year-old woman: a case report. 61
19769199 2009
30
Transitional cell tumors of the ovary: a comparative clinicopathologic, immunohistochemical, and molecular genetic analysis of Brenner tumors and transitional cell carcinomas. 61
19033864 2009
31
Expression of the urothelial differentiation markers GATA3 and placental S100 (S100P) in female genital tract transitional cell proliferations. 61
19092634 2009
32
Malignant Brenner tumor with transition from benign to malignant components: computed tomographic and magnetic resonance imaging findings with pathological correlation. 61
18664841 2008
33
The development of high-grade serous carcinoma from atypical proliferative (borderline) serous tumors and low-grade micropapillary serous carcinoma: a morphologic and molecular genetic analysis. 61
17592266 2007
34
Transitional cell carcinoma of the ovary. 61
17175479 2006
35
Immunohistochemical expression of wilms tumor gene protein in different histologic subtypes of ovarian carcinomas. 61
15628914 2005
36
[Extraovarian malignant Brenner tumor]. 61
15575388 2004
37
Borderline Brenner tumor of the ovary: MRI findings. 61
15024513 2004
38
Transitional cell carcinoma of the ovary: a morphologic study of 100 cases with emphasis on differential diagnosis. 61
15087664 2004
39
The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin. 61
14668549 2004
40
Immunoprofile of ovarian tumors with putative transitional cell (urothelial) differentiation using novel urothelial markers: histogenetic and diagnostic implications. 61
14576476 2003
41
[Malignant Brenner tumor and transitional cell ovarian carcinoma--description of two cases]. 61
11799755 2001
42
Expression of thymidine phosphorylase and vascular endothelial growth factor in epithelial ovarian cancer: correlation with angiogenesis and progression of the tumor. 61
11268481 2000
43
Chromosomal aberrations in ovarian malignant brenner tumor cell line using chromosome painting. 61
10748297 2000
44
Malignant Brenner tumor mimicking a primary squamous cell carcinoma of the cervix. 61
10479516 1999
45
Malignant Brenner tumors of the ovary and tumor markers: case reports. 61
10418561 1999
46
An unusual case of malignant Brenner tumor in association with low-grade urothelial carcinoma of the urinary bladder. A case report. 61
10475132 1999
47
Establishment and characterization of human ovarian carcinoma cell lines. 61
9299249 1997
48
Cytology of ascitic fluid in a patient with metastasizing malignant Brenner tumor of the ovary. A case report. 61
9990262 1997
49
Transitional cell neoplasms of the ovary and urinary bladder: a comparative immunohistochemical analysis. 61
8811388 1996
50
[Malignant Brenner's tumor of the ovary: description of a case]. 61
8927440 1995

Variations for Malignant Ovarian Brenner Tumor

Expression for Malignant Ovarian Brenner Tumor

Search GEO for disease gene expression data for Malignant Ovarian Brenner Tumor.

Pathways for Malignant Ovarian Brenner Tumor

GO Terms for Malignant Ovarian Brenner Tumor

Cellular components related to Malignant Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 TNFSF11 PTHLH PTH CALCA
2 extracellular space GO:0005615 8.92 TNFSF11 PTHLH PTH CALCA

Biological processes related to Malignant Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal system development GO:0001501 9.46 PTHLH PTH
2 cellular calcium ion homeostasis GO:0006874 9.43 PTH CALCA
3 monocyte chemotaxis GO:0002548 9.4 TNFSF11 CALCA
4 calcium ion homeostasis GO:0055074 9.37 TNFSF11 PTH
5 cell-cell signaling GO:0007267 9.33 PTHLH PTH CALCA
6 bone resorption GO:0045453 9.32 TNFSF11 PTH
7 negative regulation of chondrocyte differentiation GO:0032331 9.26 PTHLH PTH
8 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.13 PTHLH PTH CALCA
9 cAMP metabolic process GO:0046058 8.62 PTHLH PTH

Molecular functions related to Malignant Ovarian Brenner Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone receptor binding GO:0051428 8.96 PTHLH PTH
2 hormone activity GO:0005179 8.8 PTHLH PTH CALCA

Sources for Malignant Ovarian Brenner Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
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44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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