Malignant Ovarian Cyst disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Malignant Ovarian Cyst

MalaCards integrated aliases for Malignant Ovarian Cyst:

Name: Malignant Ovarian Cyst ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2145

NCIt ⁵⁰ C3843

UMLS ⁷³ C0235770

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Summaries for Malignant Ovarian Cyst

Disease Ontology : ¹² An ovarian cancer that is characterized by cystic structure.

MalaCards based summary : Malignant Ovarian Cyst is related to ovarian cyst and insulin-like growth factor i. An important gene associated with Malignant Ovarian Cyst is MET (MET Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Proteoglycans in cancer and Transcriptional misregulation in cancer. Related phenotype is cardiovascular system.

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Related Diseases for Malignant Ovarian Cyst

Diseases in the Ovarian Cyst family:

Malignant Ovarian Cyst

Diseases related to Malignant Ovarian Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	ovarian cyst	10.4
2	insulin-like growth factor i	9.9	IGF1 IGFBP2
3	anorexia nervosa	9.9	IGF1 IGFBP2
4	ovarian cancer	9.8
5	ovarian disease	9.8	IGF1 IGFBP2

Graphical network of the top 20 diseases related to Malignant Ovarian Cyst:

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Symptoms & Phenotypes for Malignant Ovarian Cyst

MGI Mouse Phenotypes related to Malignant Ovarian Cyst:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	8.92	FUT4 IGF1 IGFBP2 MET

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Drugs & Therapeutics for Malignant Ovarian Cyst

Search Clinical Trials , NIH Clinical Center for Malignant Ovarian Cyst

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Genetic Tests for Malignant Ovarian Cyst

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Anatomical Context for Malignant Ovarian Cyst

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Publications for Malignant Ovarian Cyst

Articles related to Malignant Ovarian Cyst:

#	Title	Authors	Year
1	Pregnancy with malignant ovarian cyst in 25-year-old female. ( 25404813 )		2014
2	Apolipoprotein concentrations are elevated in malignant ovarian cyst fluids suggesting that lipoprotein metabolism is dysregulated in epithelial ovarian cancer. ( 23627408 )	Podzielinski I....Baron A.T.	2013
3	Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid. ( 8624265 )	Kanety H....Karasik A.	1996
4	Placental protein 5 in benign and malignant ovarian cyst fluids. ( 3448769 )	Than G....Briese V.	1987
5	Placental protein 10: levels in benign and malignant ovarian cyst fluids and pleural exudates. ( 3566356 )	Than G....Bohn H.	1987
6	Pregnancy complicated by a malignant ovarian cyst. ( 15422432 )		1950

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Genes for Malignant Ovarian Cyst

Genes related to Malignant Ovarian Cyst (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MET	MET Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	14.25	DISEASES inferred ¹⁵
2	IGF1	Insulin Like Growth Factor 1	Protein Coding	13.35	DISEASES inferred ¹⁵
3	IGFBP2	Insulin Like Growth Factor Binding Protein 2	Protein Coding	11.78	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	TFPI2	Tissue Factor Pathway Inhibitor 2	Protein Coding	5.84	DISEASES inferred ¹⁵
5	FUT4	Fucosyltransferase 4	Protein Coding	4.61	DISEASES inferred ¹⁵

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Variations for Malignant Ovarian Cyst

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Expression for Malignant Ovarian Cyst

Search GEO for disease gene expression data for Malignant Ovarian Cyst.

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Pathways for Malignant Ovarian Cyst

Pathways related to Malignant Ovarian Cyst according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Proteoglycans in cancer ³⁷	11.62	IGF1 MET
2	Transcriptional misregulation in cancer ³⁷	11.53	IGF1 MET
3	Development IGF-1 receptor signaling ²² Show member pathways IL-4 Signaling Pathway ¹ Immune response IL-4 signaling pathway ²² Signal transduction AKT signaling ²²	11.52	IGF1 IGFBP2 MET
4	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.28	IGF1 MET
5	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶	9.95	IGF1 IGFBP2

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GO Terms for Malignant Ovarian Cyst

Cellular components related to Malignant Ovarian Cyst according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	8.92	IGF1 IGFBP2 MET TFPI2

Biological processes related to Malignant Ovarian Cyst according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of MAPK cascade	GO:0043410	8.96	IGF1 MET
2	positive regulation of activated T cell proliferation	GO:0042104	8.62	IGF1 IGFBP2

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