Malignant Ovarian Cyst disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Malignant Ovarian Cyst

MalaCards integrated aliases for Malignant Ovarian Cyst:

Name: Malignant Ovarian Cyst ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Endocrine diseases Reproductive diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:2145

NCIt ⁵⁰ C3843

UMLS ⁷⁰ C0235770

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Summaries for Malignant Ovarian Cyst

Disease Ontology : ¹² An ovarian cancer that is characterized by cystic structure.

MalaCards based summary : Malignant Ovarian Cyst is related to ovarian cyst and ovarian mucinous cystadenocarcinoma. An important gene associated with Malignant Ovarian Cyst is IGFBP2 (Insulin Like Growth Factor Binding Protein 2), and among its related pathways/superpathways are Matrix Metalloproteinases and Fanconi anemia pathway. Affiliated tissues include kidney and liver.

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Related Diseases for Malignant Ovarian Cyst

Diseases in the Ovarian Cyst family:

Malignant Ovarian Cyst

Diseases related to Malignant Ovarian Cyst via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)

#	Related Disease	Score	Top Affiliating Genes
1	ovarian cyst	30.6	WFDC2 IGFBP2
2	ovarian mucinous cystadenocarcinoma	10.0	RMI2 RMI1
3	rapadilino syndrome	10.0	RMI2 RMI1
4	baller-gerold syndrome	10.0	RMI2 RMI1
5	rothmund-thomson syndrome, type 2	10.0	RMI2 RMI1
6	ovarian cancer	9.9
7	polycystic liver disease 1 with or without kidney cysts	9.9
8	insulin-like growth factor i	9.9
9	pleurisy	9.9
10	ovarian epithelial cancer	9.9
11	bloom syndrome	9.9	RMI2 RMI1
12	hellp syndrome	9.6	TFPI2 MMP8

Graphical network of the top 20 diseases related to Malignant Ovarian Cyst:

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Symptoms & Phenotypes for Malignant Ovarian Cyst

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Drugs & Therapeutics for Malignant Ovarian Cyst

Search Clinical Trials , NIH Clinical Center for Malignant Ovarian Cyst

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Genetic Tests for Malignant Ovarian Cyst

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Anatomical Context for Malignant Ovarian Cyst

MalaCards organs/tissues related to Malignant Ovarian Cyst:

⁴⁰

Kidney, Liver

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Publications for Malignant Ovarian Cyst

Articles related to Malignant Ovarian Cyst:

(show all 17)

#	Title	Authors	PMID	Year
1	Strategic steps for advanced molecular imaging with magnetic resonance-based diagnostic modalities. ⁶¹	Belkic D...Belkic K	24354757	2015
2	Pregnancy with malignant ovarian cyst in 25-year-old female. ⁶¹	Patel Meenakshi	25404813	2014
3	Detecting ovarian disorders in primary care. ⁶¹	Oliver A...Overton C	24791406	2014
4	Diagnostic performance of the biomarkers HE4 and CA125 in type I and type II epithelial ovarian cancer. ⁶¹	Kristjansdottir B...Sundfeldt K	23891789	2013
5	Apolipoprotein concentrations are elevated in malignant ovarian cyst fluids suggesting that lipoprotein metabolism is dysregulated in epithelial ovarian cancer. ⁶¹	Podzielinski I...Baron AT	23627408	2013
6	[Cyst of the hepatic round ligament mimicking a malignant ovarian cyst]. ⁶¹	Jayi S...Melhouf MA	23565301	2013
7	Primary hydatidosis of female genital tract: a case report. ⁶¹	Singh AP...Sultana K	19810386	2009
8	Sonographic assessment of non-malignant ovarian cysts: does sonohistology exist? ⁶¹	de Kroon CD...Jansen FW	15192068	2004
9	Hepatocyte growth factor (HGF) in ovarian epithelial tumour fluids stimulates the migration of ovarian carcinoma cells. ⁶¹	Sowter HM...Smith SK	10508482	1999
10	Pre and intraoperative diagnosis of ovarian tumours: how accurate are we? ⁶¹	Lim FK...Arulkumaran S	9222473	1997
11	Increased insulin-like growth factor binding protein-2 (IGFBP-2) gene expression and protein production lead to high IGFBP-2 content in malignant ovarian cyst fluid. ⁶¹	Kanety H...Karasik A	8624265	1996
12	The case against aspirating ovarian cysts. ⁶¹	Trimbos JB...Hacker NF	8334637	1993
13	[The clinical value of sialyl SSEA-1 antigen in patients with gynecologic tumors]. ⁶¹	Inoue M...Taniguchi T	2892886	1987
14	Placental protein 5 in benign and malignant ovarian cyst fluids. ⁶¹	Than G...Briese V	3448769	1987
15	Placental protein 10: levels in benign and malignant ovarian cyst fluids and pleural exudates. ⁶¹	Than G...Bohn H	3566356	1987
16	Pregnancy complicated by a malignant ovarian cyst. ⁶¹	QUEHL E	15422432	1950
17	[Malignant ovarian cyst]. ⁶¹	LEROUX F	15420536	1950

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Genes for Malignant Ovarian Cyst

Genes related to Malignant Ovarian Cyst (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	IGFBP2	Insulin Like Growth Factor Binding Protein 2	Protein Coding	10.89	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	MMP8	Matrix Metallopeptidase 8	Protein Coding	5.59	DISEASES inferred ¹⁵
3	RMI2	RecQ Mediated Genome Instability 2	Protein Coding	5.51	DISEASES inferred ¹⁵
4	SAA4	Serum Amyloid A4, Constitutive	Protein Coding	5.46	DISEASES inferred ¹⁵
5	RMI1	RecQ Mediated Genome Instability 1	Protein Coding	5.3	DISEASES inferred ¹⁵
6	WFDC2	WAP Four-Disulfide Core Domain 2	Protein Coding	5.11	DISEASES inferred ¹⁵
7	PRSS3P2	PRSS3 Pseudogene 2	Pseudogene	5.06	DISEASES inferred ¹⁵
8	ZBTB12	Zinc Finger And BTB Domain Containing 12	Protein Coding	5.03	DISEASES inferred ¹⁵
9	TFPI2	Tissue Factor Pathway Inhibitor 2	Protein Coding	4.83	DISEASES inferred ¹⁵
10	APOC1	Apolipoprotein C1	Protein Coding	4.7	DISEASES inferred ¹⁵

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Variations for Malignant Ovarian Cyst

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Expression for Malignant Ovarian Cyst

Search GEO for disease gene expression data for Malignant Ovarian Cyst.

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Pathways for Malignant Ovarian Cyst

Pathways related to Malignant Ovarian Cyst according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Matrix Metalloproteinases ¹ Show member pathways Activation of Matrix Metalloproteinases ⁶⁵ Inhibition of Matrix Metalloproteinases ⁶³	10.95	TFPI2 MMP8
2	Fanconi anemia pathway ⁶⁵ ³⁶	10.59	RMI2 RMI1

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GO Terms for Malignant Ovarian Cyst

Cellular components related to Malignant Ovarian Cyst according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.55	WFDC2 TFPI2 PRSS3P2 MMP8 IGFBP2
2	extracellular region	GO:0005576	9.43	WFDC2 TFPI2 SAA4 MMP8 IGFBP2 APOC1
3	high-density lipoprotein particle	GO:0034364	8.62	SAA4 APOC1

Molecular functions related to Malignant Ovarian Cyst according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	serine-type endopeptidase inhibitor activity	GO:0004867	8.62	WFDC2 TFPI2

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Sources for Malignant Ovarian Cyst

¹ BioSystems

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²⁵ GeneReviews

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²⁷ GEO DataSets

²⁸ GO

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³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

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⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

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⁵⁹ PathCards

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⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia