MCID: MLG076
MIFTS: 27

Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

MalaCards integrated aliases for Malignant Ovarian Surface Epithelial-Stromal Neoplasm:

Name: Malignant Ovarian Surface Epithelial-Stromal Neoplasm 12 15
Malignant Ovarian Surface Epithelial-Stromal Tumor 71

Classifications:



External Ids:

Disease Ontology 12 DOID:2151
NCIt 49 C40026
UMLS 71 C1518236

Summaries for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Disease Ontology : 12 An ovary epithelial cancer that has material basis in epithelial and stromal tissue and arises from the surface epithelium of the ovary.

MalaCards based summary : Malignant Ovarian Surface Epithelial-Stromal Neoplasm, also known as malignant ovarian surface epithelial-stromal tumor, is related to malignant ovarian brenner tumor and ovarian carcinosarcoma. An important gene associated with Malignant Ovarian Surface Epithelial-Stromal Neoplasm is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are MicroRNAs in cancer and Parkinsons Disease Pathway. Affiliated tissues include ovary, bone and thyroid.

Related Diseases for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Diseases related to Malignant Ovarian Surface Epithelial-Stromal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 235)
# Related Disease Score Top Affiliating Genes
1 malignant ovarian brenner tumor 11.7
2 ovarian carcinosarcoma 11.7
3 endometriosis of ovary 10.7 MIR30E MIR145 MIR141
4 retinal vascular disease 10.7 MIR30A MIR21 MIR199A1 H2AC18
5 cystadenocarcinoma 10.7 TP53 SERPINA3 MIR30A MIR199A1
6 papillary serous adenocarcinoma 10.7 TP53 MIR30E MIR30A MIR141
7 serous cystadenocarcinoma 10.7 TP53 MIR30A MIR199A1 H2AC18
8 cecal disease 10.7 SERPINA3 H2AC18 CCR6
9 thyroid gland anaplastic carcinoma 10.7 TP53 MIR34C MIR30A MIR17
10 extrinsic cardiomyopathy 10.7 MIR21 ICOSLG H2AC18 CCR6
11 autoimmune disease of skin and connective tissue 10.7 SERPINA3 ICOSLG CCR6
12 listeriosis 10.7 ICOSLG H2AC18 CCR6
13 bacterial infectious disease 10.7 SERPINA3 ICOSLG H2AC18 CCR6
14 herpangina 10.7 TP53 H2AC18 CCR6
15 lichen disease 10.7 TP53 ICOSLG CCR6
16 vaginal disease 10.7 TP53 H2AC18 CCR6
17 mast cell neoplasm 10.7 SERPINA3 ICOSLG H2AC18
18 intrinsic cardiomyopathy 10.7 MIR30A MIR21 MIR199A1 ICOSLG H2AC18
19 coccidiosis 10.7 SERPINA3 ICOSLG H2AC18 CCR6
20 aortic valve disease 2 10.7 SERPINA3 MIR21 MIR199A1 MIR17
21 papillary adenocarcinoma 10.7 TP53 MIR30E MIR30A MIR21 MIR141
22 autoimmune disease of urogenital tract 10.7 ICOSLG H2AC18 CCR6
23 tonsil cancer 10.7 TP53 SERPINA3 MIR199A1 H2AC18
24 thymus gland disease 10.7 TP53 ICOSLG H2AC18 CCR6
25 thymus cancer 10.7 TP53 ICOSLG H2AC18 CCR6
26 neuromuscular junction disease 10.7 SERPINA3 ICOSLG H2AC18 CCR6
27 iga glomerulonephritis 10.7 MIR30A ICOSLG CCR6
28 lipid storage disease 10.7 SERPINA3 MIR199A1 H2AC18 CCR6
29 lymph node disease 10.7 SERPINA3 MIR145 ICOSLG CCR6
30 lymphoma, hodgkin, classic 10.7 MIR30A MIR21 MIR200A ICOSLG CCR6
31 autoimmune disease of endocrine system 10.7 ICOSLG H2AC18 CCR6
32 hypersensitivity reaction type iv disease 10.7 SERPINA3 ICOSLG H2AC18 CCR6
33 respiratory system benign neoplasm 10.7 TP53 MIR30C1 H2AC18
34 anus disease 10.7 TP53 H2AC18 CCR6
35 substance abuse 10.7 SERPINA3 MIR199A1 H2AC18 CCR6
36 lymphadenitis 10.7 SERPINA3 MIR145 ICOSLG CCR6
37 rectal disease 10.7 TP53 H2AC18 CCR6
38 hair disease 10.7 TP53 ICOSLG H2AC18 CCR6
39 monoclonal gammopathy of uncertain significance 10.7 TP53 ICOSLG CCR6
40 blood coagulation disease 10.7 SERPINA3 ICOSLG H2AC18 CCR6
41 mixed cell type cancer 10.7 TP53 SERPINA3 H2AC18
42 thyroid gland papillary carcinoma 10.7 MIR509-1 MIR30E MIR30A MIR200A MIR199A1 MIR17
43 luminal breast carcinoma 10.7 TP53 MIR21 H2AC18
44 chediak-higashi syndrome 10.7 SERPINA3 ICOSLG H2AC18 CCR6
45 parasitic helminthiasis infectious disease 10.7 SERPINA3 MIR21 ICOSLG H2AC18 CCR6
46 parasitic protozoa infectious disease 10.7 SERPINA3 ICOSLG H2AC18 CCR6
47 plasma cell neoplasm 10.7 TP53 SERPINA3 ICOSLG
48 uveal disease 10.7 SERPINA3 MIR199A1 ICOSLG H2AC18 CCR6
49 systemic scleroderma 10.7 MIR30A MIR21 ICOSLG H2AC18 CCR6
50 spinal cord disease 10.7 ICOSLG H2AC18 CCR6

Graphical network of the top 20 diseases related to Malignant Ovarian Surface Epithelial-Stromal Neoplasm:



Diseases related to Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Symptoms & Phenotypes for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Drugs & Therapeutics for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Search Clinical Trials , NIH Clinical Center for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Genetic Tests for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Anatomical Context for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

MalaCards organs/tissues related to Malignant Ovarian Surface Epithelial-Stromal Neoplasm:

40
Ovary, Bone, Thyroid, Breast, Skin, Lung, B Cells

Publications for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Variations for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Expression for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Search GEO for disease gene expression data for Malignant Ovarian Surface Epithelial-Stromal Neoplasm.

Pathways for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Pathways related to Malignant Ovarian Surface Epithelial-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.93 TP53 MIR34C MIR30E MIR30C1 MIR30A MIR29C
2 11.48 MIR34C MIR30E MIR30A MIR17
3 11.16 TP53 MIR34C MIR27A MIR145
4 10.94 TP53 MIR34C MIR29C
5 10.89 MIR30E MIR30C1 MIR200A MIR141
6 10.48 MIR199A1 MIR145

GO Terms for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

Cellular components related to Malignant Ovarian Surface Epithelial-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.32 SERPINA3 MIR30E MIR30C1 MIR30A MIR29C MIR27A

Biological processes related to Malignant Ovarian Surface Epithelial-Stromal Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.8 TP53 MIR509-1 MIR29C MIR27A MIR21 MIR17
2 negative regulation of angiogenesis GO:0016525 9.76 MIR29C MIR21 MIR193A MIR145
3 transforming growth factor beta receptor signaling pathway GO:0007179 9.74 TP53 MIR30A MIR21
4 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.71 MIR29C MIR21 MIR193A
5 negative regulation of protein kinase B signaling GO:0051898 9.7 MIR34C MIR29C MIR145
6 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.67 MIR27A MIR21 MIR17
7 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.65 MIR29C MIR196A1 MIR193A
8 negative regulation of vascular endothelial cell proliferation GO:1905563 9.61 MIR30E MIR29C MIR193A
9 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.58 MIR27A MIR199A1 MIR17
10 positive regulation of connective tissue replacement GO:1905205 9.56 MIR34C MIR199A1
11 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.56 MIR30E MIR21 MIR199A1 MIR145
12 positive regulation of metalloendopeptidase activity GO:1904685 9.55 MIR21 MIR17
13 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.54 MIR34C MIR199A1 MIR17
14 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.51 MIR21 MIR17
15 gene silencing by miRNA GO:0035195 9.5 MIR509-1 MIR34C MIR30E MIR30C1 MIR30A MIR29C
16 negative regulation of sprouting angiogenesis GO:1903671 9.46 MIR34C MIR30E MIR30C1 MIR17
17 miRNA mediated inhibition of translation GO:0035278 9.35 MIR30A MIR27A MIR21 MIR17 MIR145

Molecular functions related to Malignant Ovarian Surface Epithelial-Stromal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.47 MIR509-1 MIR30E MIR30C1 MIR30A MIR29C MIR27A

Sources for Malignant Ovarian Surface Epithelial-Stromal Neoplasm

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10 dbSNP
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17 EFO
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68 SNOMED-CT via HPO
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72 UMLS via Orphanet
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