MCID: MLG157
MIFTS: 34

Malignant Pheochromocytoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Malignant Pheochromocytoma

MalaCards integrated aliases for Malignant Pheochromocytoma:

Name: Malignant Pheochromocytoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080347

Summaries for Malignant Pheochromocytoma

Disease Ontology : 12 An adrenal medulla cancer that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones.

MalaCards based summary : Malignant Pheochromocytoma is related to paraganglioma and pheochromocytoma. An important gene associated with Malignant Pheochromocytoma is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B). The drugs Methylprednisolone hemisuccinate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related phenotype is nervous system.

Related Diseases for Malignant Pheochromocytoma

Diseases in the Pheochromocytoma family:

Malignant Pheochromocytoma Sporadic Pheochromocytoma

Diseases related to Malignant Pheochromocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 paraganglioma 30.5 SYP SST SDHB ENO2 CHGA
2 pheochromocytoma 30.4 SYP SST SLC6A2 SDHB PNMT ENO2
3 ganglioneuroblastoma 29.9 ENO2 SYP
4 multiple endocrine neoplasia, type iia 29.9 CALCA SDHB
5 multiple endocrine neoplasia 29.8 SDHB PNMT CHGA CALCA
6 ganglioneuroma 29.7 CHGA ENO2 SYP
7 neuroblastoma 29.7 ENO2 NME1 SLC6A2 SYP
8 adrenal gland pheochromocytoma 10.5
9 gastrointestinal system benign neoplasm 10.3 CHGA SST
10 serotonin syndrome 10.3 CHGA SST
11 gastrinoma 10.3 CHGA SST
12 gastrointestinal neuroendocrine benign tumor 10.3 CHGA SST
13 gastric neuroendocrine neoplasm 10.2 CHGA SST
14 paragangliomas 1 10.2 CHGA SDHB
15 pituitary carcinoma 10.2 CHGA SST
16 duodenum cancer 10.2 ENO2 SST
17 ileum cancer 10.2 ENO2 SST
18 tubular adenocarcinoma 10.2 CHGA SYP
19 gastric tubular adenocarcinoma 10.2 CHGA SYP
20 glucagonoma 10.2 CHGA SST
21 insulinomatosis and diabetes mellitus 10.2 CHGA SST
22 intracranial primitive neuroectodermal tumor 10.2 CHGA ENO2
23 ectopic cushing syndrome 10.2 SST SYP
24 colonic pseudo-obstruction 10.2 SST SYP
25 epithelioid malignant peripheral nerve sheath tumor 10.2 CHGA ENO2
26 vipoma 10.2 CHGA SST
27 goblet cell carcinoid 10.2 CHGA ENO2
28 ureter small cell carcinoma 10.2 CHGA SYP
29 esophageal neuroendocrine tumor 10.2 CHGA SYP
30 mongolian spot 10.2 ENO2 SST
31 ovarian large-cell neuroendocrine carcinoma 10.2 CHGA SYP
32 acinar cell cystadenocarcinoma 10.2 CHGA SYP
33 retroperitoneal neuroblastoma 10.2 ENO2 SST
34 peritoneal serous adenocarcinoma 10.2 CHGA SYP
35 cellular ependymoma 10.2 CHGA SYP
36 primary hepatic neuroendocrine carcinoma 10.2 CHGA SYP
37 chordoid meningioma 10.2 CHGA SYP
38 malignant glandular tumor of peripheral nerve sheath 10.2 SST SYP
39 olfactory groove meningioma 10.2 CHGA SYP
40 chondrosarcoma, extraskeletal myxoid 10.2 ENO2 SYP
41 central nervous system benign neoplasm 10.2 ENO2 SYP
42 pancreatic serous cystadenoma 10.2 CHGA SYP
43 mixed cell type cancer 10.2 ENO2 SYP
44 adrenal rest tumor 10.2 ENO2 SYP
45 cystadenoma 10.2 CHGA SYP
46 optic nerve neoplasm 10.2 ENO2 SYP
47 medullomyoblastoma 10.2 ENO2 SYP
48 adult medulloblastoma 10.2 ENO2 SYP
49 conventional angiosarcoma 10.2 CHGA SYP
50 optic nerve glioma 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Malignant Pheochromocytoma:



Diseases related to Malignant Pheochromocytoma

Symptoms & Phenotypes for Malignant Pheochromocytoma

MGI Mouse Phenotypes related to Malignant Pheochromocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 CHGA ENO2 LGALS3 NME1 PNMT SLC6A2

Drugs & Therapeutics for Malignant Pheochromocytoma

Drugs for Malignant Pheochromocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
2
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
4
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
5
Carbidopa Approved Phase 2 28860-95-9 34359 38101
6
Iodine Approved, Investigational Phase 1, Phase 2,Phase 2 7553-56-2 807
7
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
8
Lenvatinib Approved, Investigational Phase 2 417716-92-8
9
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
10
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
11
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
12 alpha-methyltyrosine Phase 2
13 Methylprednisolone acetate Phase 2
14 Prednisolone acetate Phase 2
15 tyrosine Phase 2
16 3-Iodobenzylguanidine Phase 2,Phase 1
17 Radiopharmaceuticals Phase 2,Phase 1
18 cadexomer iodine Phase 1, Phase 2,Phase 2
19 Angiogenesis Modulating Agents Phase 2
20 Angiogenesis Inhibitors Phase 2
21 Protein Kinase Inhibitors Phase 2
22
Racepinephrine Approved Not Applicable 329-65-7 838
23
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
24 Vasoconstrictor Agents Not Applicable
25 Anti-Asthmatic Agents Not Applicable
26 Adrenergic beta-Agonists Not Applicable
27 Mydriatics Not Applicable
28 Peripheral Nervous System Agents Not Applicable
29 Adrenergic alpha-Agonists Not Applicable
30 Epinephryl borate Not Applicable
31 Adrenergic Agonists Not Applicable
32 Sympathomimetics Not Applicable
33 Neurotransmitter Agents Not Applicable
34 Autonomic Agents Not Applicable
35 Respiratory System Agents Not Applicable
36 Adrenergic Agents Not Applicable
37 Bronchodilator Agents Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 131MIBG to Treat Malignant Pheochromocytoma Completed NCT00028106 Phase 2 [131]I-MIBG;6-[18F]Fluorodopamine;[123]I-MIBG
2 Phase 1 Study of Iobenguane (MIBG) I 131 in Patients With Malignant Pheochromocytoma/Paraganglioma Completed NCT00458952 Phase 1, Phase 2 Ultratrace Iobenguane (MIBG) I 131
3 Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma Completed NCT00843037 Phase 2 Sunitinib
4 Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma Recruiting NCT00107289 Phase 2
5 Study to Evaluate the Effects of Cabozantinib in Patients With Unresectable Metastatic Pheochromocytomas and Paragangliomas Recruiting NCT02302833 Phase 2 Cabozantinib
6 First International Randomized Study in Malignant Progressive Pheochromocytoma and Paraganglioma Recruiting NCT01371201 Phase 2 Sunitinib;Placebo
7 Lenvatinib in Treating Patients With Metastatic or Advanced Pheochromocytoma or Paraganglioma That Cannot Be Removed by Surgery Recruiting NCT03008369 Phase 2 Lenvatinib
8 Dovitinib in Neuroendocrine Tumors Active, not recruiting NCT01635907 Phase 2 Dovitinib
9 Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma Active, not recruiting NCT01967576 Phase 2 Axitinib (AG-013736)
10 Pazopanib Hydrochloride in Treating Patients With Advanced or Progressive Malignant Pheochromocytoma or Paraganglioma Terminated NCT01340794 Phase 2 Pazopanib Hydrochloride
11 ULTRATRACE Iobenguane I 131 in Patients With Malignant Pheochromocytoma, Paraganglioma, or Metastatic Carcinoid Completed NCT00339131 Phase 1 Ultratrace iobenguane I 131
12 Towards an Easy-to-use Adrenal Cancer/Tumor Identity Card Unknown status NCT02672020 Not Applicable
13 Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma Available NCT01377532 131 I-Metaiodobenzylguanidine (131 I-MIBG)

Search NIH Clinical Center for Malignant Pheochromocytoma

Genetic Tests for Malignant Pheochromocytoma

Anatomical Context for Malignant Pheochromocytoma

MalaCards organs/tissues related to Malignant Pheochromocytoma:

41
Bone, Lung, Kidney, Colon, Pituitary, Thyroid, Pineal

Publications for Malignant Pheochromocytoma

Articles related to Malignant Pheochromocytoma:

(show top 50) (show all 287)
# Title Authors Year
1
Takotsubo syndrome induced by malignant pheochromocytoma in a patient with type 2 papillary renal cell carcinoma - a case report. ( 29785166 )
2018
2
Recent advances in the management of malignant pheochromocytoma and paraganglioma: focus on tyrosine kinase and hypoxia-inducible factor inhibitors. ( 30109021 )
2018
3
Temozolomide treatment of a malignant pheochromocytoma and an unresectable MAX-related paraganglioma. ( 29099418 )
2018
4
Propofol Prevents the Progression of Malignant Pheochromocytoma In Vitro and In Vivo. ( 29565198 )
2018
5
131-I MIBG therapy of malignant pheochromocytoma and paraganglioma tumours - a single-centre study. ( 29645065 )
2018
6
Giant malignant pheochromocytoma in an elderly patient: A case report. ( 29742697 )
2018
7
What determines mortality in malignant pheochromocytoma? - Report of a case with eighteen-year survival and review of the literature. ( 29768630 )
2018
8
Successful treatment of malignant pheochromocytoma with sacrum metastases: A case report. ( 30170467 )
2018
9
Malignant Pheochromocytoma with Widespread Bony and Pulmonary Metastases. ( 30483454 )
2018
10
DNA methylation analysis in malignant pheochromocytoma and paraganglioma. ( 29067245 )
2017
11
Malignant pheochromocytoma in the anterior mediastinum with sternal invasion: a case report. ( 28449504 )
2017
12
Surgical Treatment of Malignant Pheochromocytoma and Paraganglioma: Retrospective Case Series. ( 28058556 )
2017
13
NVP-AUY922, a novel HSP90 inhibitor, inhibits the progression of malignant pheochromocytoma in vitro and in vivo. ( 28458565 )
2017
14
A Case of Malignant Pheochromocytoma Presenting 7 Years After the Initial Surgery. ( 28331462 )
2017
15
Proteasome Inhibitors: A Potential Medical Therapy for Malignant Pheochromocytoma. ( 28977615 )
2017
16
Malignant pheochromocytoma with multiple vertebral metastases causing acute incomplete paralysis during pregnancy: Literature review with one case report. ( 29095319 )
2017
17
Perioperative Management of Adrenalectomy and Inferior Vena Cava Reconstruction in a Patient With a Large, Malignant Pheochromocytoma With Vena Caval Extension. ( 27810406 )
2017
18
Malignant pheochromocytoma-paraganglioma: pathogenesis, TNM staging, and current clinical trials. ( 28234804 )
2017
19
SDHB mutation carriers with malignant pheochromocytoma respond better to CVD. ( 28566531 )
2017
20
Malignant Pheochromocytoma and Paraganglioma: 272 Patients Over 55 Years. ( 28605453 )
2017
21
Aggressive Imaging Features in a Malignant Pheochromocytoma With a Novel Mutation of the SDHB Gene. ( 28650885 )
2017
22
Phase II trial of pazopanib in advanced/progressive malignant pheochromocytoma and paraganglioma. ( 28685225 )
2017
23
A malignant pheochromocytoma in a child with von Hippel-Lindau mutation. ( 28781534 )
2017
24
Recurrent Malignant Pheochromocytoma with Lymph Nodal Metastasis in a Child: A Rare Case. ( 28974878 )
2017
25
Giant multicystic malignant pheochromocytoma. ( 29260138 )
2017
26
ATRX driver mutation in a composite malignant pheochromocytoma. ( 27209355 )
2016
27
Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis. ( 26670126 )
2016
28
Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma. ( 27007161 )
2016
29
Patterns of Use and Short-Term Outcomes of Minimally Invasive Surgery for Malignant Pheochromocytoma: A Population-Level Study. ( 26675927 )
2016
30
Patterns of Use and Short-Term Outcomes of Minimally Invasive Surgery for Malignant Pheochromocytoma: A Population-Level Study: Reply. ( 26791742 )
2016
31
Clinical course and prognostic factors in patients with malignant pheochromocytoma and paraganglioma: A single institution experience. ( 26464058 )
2015
32
Patterns of Use and Short-Term Outcomes of Minimally Invasive Surgery for Malignant Pheochromocytoma: A Population-Level Study. ( 25821949 )
2015
33
Targeting of mTORC2 may have advantages over selective targeting of mTORC1 in the treatment of malignant pheochromocytoma. ( 25666752 )
2015
34
Breast Metastasis Detected on Ga-68 DOTATATE Positron Emission Tomography/Computed Tomography Imaging in Malignant Pheochromocytoma. ( 25709553 )
2015
35
Malignant pheochromocytoma with lung metastasis after right adrenalectomy for pheochromocytoma eleven years ago. ( 25922747 )
2015
36
Malignant pheochromocytoma in the elderly: which is the best management in clinical practice? ( 26378491 )
2015
37
Flank pain after minor trauma as the initial manifestation of malignant pheochromocytoma; a case report. ( 28197483 )
2015
38
Incidentally Detected Inoperable Malignant Pheochromocytoma with Hepatic Metastasis Treated by Transcatheter Arterial Chemoembolization. ( 25325276 )
2014
39
Recurrent malignant pheochromocytoma with unusual omental metastasis: (68)Ga-DOTANOC PET/CT and (131)I-MIBG SPECT/CT scintigraphy findings. ( 25400380 )
2014
40
Calcific malignant pheochromocytoma. ( 24170888 )
2014
41
Sunitinib for refractory malignant pheochromocytoma: two case reports. ( 24510251 )
2014
42
In Silico Analysis Identification of a Novel Germ-Line VHL Mutation in a Patient of Malignant Pheochromocytoma. ( 24518179 )
2014
43
Malignant pheochromocytoma in a 16-year-old patient with neurofibromatosis type 1. ( 24555864 )
2014
44
A Case of Malignant Pheochromocytoma Detected during Fertility Treatment. ( 24653857 )
2014
45
Combination chemotherapy regimen in a patient with metastatic malignant pheochromocytoma and neurofibromatosis type 1. ( 24711885 )
2014
46
Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma. ( 24891137 )
2014
47
Malignant pheochromocytoma secreting vasoactive intestinal peptide and response to sunitinib: a case report and literature review. ( 24936559 )
2014
48
External beam radiation therapy in treatment of malignant pheochromocytoma and paraganglioma. ( 25019060 )
2014
49
Giant malignant pheochromocytoma with palpable rib metastases. ( 25152826 )
2014
50
Malignant pheochromocytoma and paraganglioma: future considerations for therapy. ( 23598685 )
2013

Variations for Malignant Pheochromocytoma

Expression for Malignant Pheochromocytoma

Search GEO for disease gene expression data for Malignant Pheochromocytoma.

Pathways for Malignant Pheochromocytoma

GO Terms for Malignant Pheochromocytoma

Biological processes related to Malignant Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to pain GO:0048265 8.62 CALCA SLC6A2

Sources for Malignant Pheochromocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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