MCID: MLG157
MIFTS: 35

Malignant Pheochromocytoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Malignant Pheochromocytoma

MalaCards integrated aliases for Malignant Pheochromocytoma:

Name: Malignant Pheochromocytoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080347

Summaries for Malignant Pheochromocytoma

Disease Ontology : 12 An adrenal medulla cancer that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones.

MalaCards based summary : Malignant Pheochromocytoma is related to extra-adrenal pheochromocytoma and paraganglioma. An important gene associated with Malignant Pheochromocytoma is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B). The drugs Carbidopa and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lung and colon, and related phenotype is nervous system.

Related Diseases for Malignant Pheochromocytoma

Diseases in the Pheochromocytoma family:

Malignant Pheochromocytoma Sporadic Pheochromocytoma

Diseases related to Malignant Pheochromocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 extra-adrenal pheochromocytoma 32.1 PNMT SDHB
2 paraganglioma 30.4 CHGA ENO2 SDHB SST SYP
3 ganglioneuroblastoma 30.0 ENO2 SYP
4 multiple endocrine neoplasia, type iia 29.8 CALCA SDHB
5 von hippel-lindau syndrome 29.8 CHGA PNMT SDHB
6 ganglioneuroma 29.8 CHGA ENO2 SYP
7 hemangioma 29.7 CHGA ENO2 SYP
8 pheochromocytoma 29.6 CALCA CHGA ENO2 PNMT SDHB SLC6A2
9 multiple endocrine neoplasia 29.5 CALCA CHGA PNMT SDHB
10 adrenal gland pheochromocytoma 11.6
11 paragangliomas 4 11.2
12 gastrointestinal system benign neoplasm 10.4 CHGA SST
13 serotonin syndrome 10.4 CHGA SST
14 gastrinoma 10.4 CHGA SST
15 gastrointestinal neuroendocrine benign tumor 10.4 CHGA SST
16 gastric neuroendocrine neoplasm 10.4 CHGA SST
17 paragangliomas 1 10.4 CHGA SDHB
18 pituitary carcinoma 10.4 CHGA SST
19 duodenum cancer 10.4 ENO2 SST
20 ileum cancer 10.4 ENO2 SST
21 tubular adenocarcinoma 10.4 CHGA SYP
22 glucagonoma 10.4 CHGA SST
23 gastric tubular adenocarcinoma 10.3 CHGA SYP
24 insulinomatosis and diabetes mellitus 10.3 CHGA SST
25 intracranial primitive neuroectodermal tumor 10.3 CHGA ENO2
26 ectopic cushing syndrome 10.3 SST SYP
27 colonic pseudo-obstruction 10.3 SST SYP
28 epithelioid malignant peripheral nerve sheath tumor 10.3 CHGA ENO2
29 vipoma 10.3 CHGA SST
30 goblet cell carcinoid 10.3 CHGA ENO2
31 ureter small cell carcinoma 10.3 CHGA SYP
32 mongolian spot 10.3 ENO2 SST
33 esophageal neuroendocrine tumor 10.3 CHGA SYP
34 ovarian large-cell neuroendocrine carcinoma 10.3 CHGA SYP
35 acinar cell cystadenocarcinoma 10.3 CHGA SYP
36 retroperitoneal neuroblastoma 10.3 ENO2 SST
37 peritoneal serous adenocarcinoma 10.3 CHGA SYP
38 cellular ependymoma 10.3 CHGA SYP
39 primary hepatic neuroendocrine carcinoma 10.3 CHGA SYP
40 chordoid meningioma 10.3 CHGA SYP
41 malignant glandular tumor of peripheral nerve sheath 10.3 SST SYP
42 olfactory groove meningioma 10.3 CHGA SYP
43 pancreatic serous cystadenoma 10.3 CHGA SYP
44 chondrosarcoma, extraskeletal myxoid 10.3 ENO2 SYP
45 cystadenoma 10.3 CHGA SYP
46 mixed cell type cancer 10.3 ENO2 SYP
47 conventional angiosarcoma 10.3 CHGA SYP
48 adrenal rest tumor 10.3 ENO2 SYP
49 optic nerve neoplasm 10.3 ENO2 SYP
50 medullomyoblastoma 10.3 ENO2 SYP

Graphical network of the top 20 diseases related to Malignant Pheochromocytoma:



Diseases related to Malignant Pheochromocytoma

Symptoms & Phenotypes for Malignant Pheochromocytoma

MGI Mouse Phenotypes related to Malignant Pheochromocytoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 CHGA ENO2 LGALS3 NME1 PNMT SLC6A2

Drugs & Therapeutics for Malignant Pheochromocytoma

Drugs for Malignant Pheochromocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carbidopa Approved Phase 2 28860-95-9 34359
2
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
3
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
4
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
5
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
6
Iodine Approved, Investigational Phase 1, Phase 2,Phase 2 7553-56-2 807
7
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
8
Lenvatinib Approved, Investigational Phase 2 417716-92-8
9
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
10
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
11
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 444795 5538
12
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
13 Methylprednisolone Acetate Phase 2
14 Prednisolone acetate Phase 2
15 Radiopharmaceuticals Phase 2,Phase 1
16 alpha-methyltyrosine Phase 2
17 3-Iodobenzylguanidine Phase 2,Phase 1
18 cadexomer iodine Phase 1, Phase 2,Phase 2
19 Angiogenesis Modulating Agents Phase 2
20 Angiogenesis Inhibitors Phase 2
21 Protein Kinase Inhibitors Phase 2
22
Racepinephrine Approved Not Applicable 329-65-7 838
23
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
24 Adrenergic alpha-Agonists Not Applicable
25 Sympathomimetics Not Applicable
26 Peripheral Nervous System Agents Not Applicable
27 Adrenergic Agonists Not Applicable
28 Bronchodilator Agents Not Applicable
29 Neurotransmitter Agents Not Applicable
30 Epinephryl borate Not Applicable
31 Respiratory System Agents Not Applicable
32 Anti-Asthmatic Agents Not Applicable
33 Adrenergic beta-Agonists Not Applicable
34 Vasoconstrictor Agents Not Applicable
35 Mydriatics Not Applicable
36 Autonomic Agents Not Applicable
37 Adrenergic Agents Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 131MIBG to Treat Malignant Pheochromocytoma Completed NCT00028106 Phase 2 [131]I-MIBG;6-[18F]Fluorodopamine;[123]I-MIBG
2 Phase 1 Study of Iobenguane (MIBG) I 131 in Patients With Malignant Pheochromocytoma/Paraganglioma Completed NCT00458952 Phase 1, Phase 2 Ultratrace Iobenguane (MIBG) I 131
3 Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma Recruiting NCT00107289 Phase 2
4 Study to Evaluate the Effects of Cabozantinib in Patients With Unresectable Metastatic Pheochromocytomas and Paragangliomas Recruiting NCT02302833 Phase 2 Cabozantinib
5 First International Randomized Study in Malignant Progressive Pheochromocytoma and Paraganglioma Recruiting NCT01371201 Phase 2 Sunitinib;Placebo
6 Lenvatinib in Treating Patients With Metastatic or Advanced Pheochromocytoma or Paraganglioma That Cannot Be Removed by Surgery Recruiting NCT03008369 Phase 2 Lenvatinib
7 Dovitinib in Neuroendocrine Tumors Active, not recruiting NCT01635907 Phase 2 Dovitinib
8 Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma Active, not recruiting NCT01967576 Phase 2 Axitinib (AG-013736)
9 Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma Active, not recruiting NCT00843037 Phase 2 Sunitinib
10 Pazopanib Hydrochloride in Treating Patients With Advanced or Progressive Malignant Pheochromocytoma or Paraganglioma Terminated NCT01340794 Phase 2 Pazopanib Hydrochloride
11 ULTRATRACE Iobenguane I 131 in Patients With Malignant Pheochromocytoma, Paraganglioma, or Metastatic Carcinoid Completed NCT00339131 Phase 1 Ultratrace iobenguane I 131
12 Towards an Easy-to-use Adrenal Cancer/Tumor Identity Card Unknown status NCT02672020 Not Applicable
13 Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma Available NCT01377532 131 I-Metaiodobenzylguanidine (131 I-MIBG)

Search NIH Clinical Center for Malignant Pheochromocytoma

Genetic Tests for Malignant Pheochromocytoma

Anatomical Context for Malignant Pheochromocytoma

MalaCards organs/tissues related to Malignant Pheochromocytoma:

42
Thyroid, Lung, Colon, Pineal, Bone, Adrenal Gland, Kidney

Publications for Malignant Pheochromocytoma

Articles related to Malignant Pheochromocytoma:

(show top 50) (show all 293)
# Title Authors Year
1
Prognosis of Malignant Pheochromocytoma and Paraganglioma (MAPP-Prono Study): A European Network for the Study of Adrenal Tumors Retrospective Study. ( 30715419 )
2019
2
Expression of PDK1 in malignant pheochromocytoma as a new promising potential therapeutic target. ( 30759304 )
2019
3
Prognostic Factors of Malignant Pheochromocytoma and Paraganglioma: A Combined SEER and TCGA Databases Review. ( 30919391 )
2019
4
Correction: Prognostic Factors of Malignant Pheochromocytoma and Paraganglioma: A Combined SEER and TCGA Databases Review. ( 30986868 )
2019
5
Anti-tumor effects and potential therapeutic response biomarkers in α-emitting meta-211At-astato-benzylguanidine therapy for malignant pheochromocytoma explored by RNA-sequencing. ( 31037122 )
2019
6
Preclinical Evaluation of the Acute Radiotoxicity of the α-Emitting Molecular-Targeted Therapeutic Agent 211At-MABG for the Treatment of Malignant Pheochromocytoma in Normal Mice. ( 31078058 )
2019
7
Recent advances in the management of malignant pheochromocytoma and paraganglioma: focus on tyrosine kinase and hypoxia-inducible factor inhibitors. ( 30109021 )
2018
8
Temozolomide treatment of a malignant pheochromocytoma and an unresectable MAX-related paraganglioma. ( 29099418 )
2018
9
Propofol Prevents the Progression of Malignant Pheochromocytoma In Vitro and In Vivo. ( 29565198 )
2018
10
131-I MIBG therapy of malignant pheochromocytoma and paraganglioma tumours - a single-centre study. ( 29645065 )
2018
11
Giant malignant pheochromocytoma in an elderly patient: A case report. ( 29742697 )
2018
12
What determines mortality in malignant pheochromocytoma? - Report of a case with eighteen-year survival and review of the literature. ( 29768630 )
2018
13
Takotsubo syndrome induced by malignant pheochromocytoma in a patient with type 2 papillary renal cell carcinoma - a case report. ( 29785166 )
2018
14
Successful treatment of malignant pheochromocytoma with sacrum metastases: A case report. ( 30170467 )
2018
15
Malignant Pheochromocytoma with Widespread Bony and Pulmonary Metastases. ( 30483454 )
2018
16
Perioperative Management of Adrenalectomy and Inferior Vena Cava Reconstruction in a Patient With a Large, Malignant Pheochromocytoma With Vena Caval Extension. ( 27810406 )
2017
17
Surgical Treatment of Malignant Pheochromocytoma and Paraganglioma: Retrospective Case Series. ( 28058556 )
2017
18
Malignant pheochromocytoma-paraganglioma: pathogenesis, TNM staging, and current clinical trials. ( 28234804 )
2017
19
A Case of Malignant Pheochromocytoma Presenting 7 Years After the Initial Surgery. ( 28331462 )
2017
20
Malignant pheochromocytoma in the anterior mediastinum with sternal invasion: a case report. ( 28449504 )
2017
21
NVP-AUY922, a novel HSP90 inhibitor, inhibits the progression of malignant pheochromocytoma in vitro and in vivo. ( 28458565 )
2017
22
SDHB mutation carriers with malignant pheochromocytoma respond better to CVD. ( 28566531 )
2017
23
Malignant Pheochromocytoma and Paraganglioma: 272 Patients Over 55 Years. ( 28605453 )
2017
24
Aggressive Imaging Features in a Malignant Pheochromocytoma With a Novel Mutation of the SDHB Gene. ( 28650885 )
2017
25
Phase II trial of pazopanib in advanced/progressive malignant pheochromocytoma and paraganglioma. ( 28685225 )
2017
26
A malignant pheochromocytoma in a child with von Hippel-Lindau mutation. ( 28781534 )
2017
27
Recurrent Malignant Pheochromocytoma with Lymph Nodal Metastasis in a Child: A Rare Case. ( 28974878 )
2017
28
Proteasome Inhibitors: A Potential Medical Therapy for Malignant Pheochromocytoma. ( 28977615 )
2017
29
DNA methylation analysis in malignant pheochromocytoma and paraganglioma. ( 29067245 )
2017
30
Malignant pheochromocytoma with multiple vertebral metastases causing acute incomplete paralysis during pregnancy: Literature review with one case report. ( 29095319 )
2017
31
Giant multicystic malignant pheochromocytoma. ( 29260138 )
2017
32
Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis. ( 26670126 )
2016
33
Patterns of Use and Short-Term Outcomes of Minimally Invasive Surgery for Malignant Pheochromocytoma: A Population-Level Study. ( 26675927 )
2016
34
Patterns of Use and Short-Term Outcomes of Minimally Invasive Surgery for Malignant Pheochromocytoma: A Population-Level Study: Reply. ( 26791742 )
2016
35
Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma. ( 27007161 )
2016
36
ATRX driver mutation in a composite malignant pheochromocytoma. ( 27209355 )
2016
37
Targeting of mTORC2 may have advantages over selective targeting of mTORC1 in the treatment of malignant pheochromocytoma. ( 25666752 )
2015
38
Breast Metastasis Detected on Ga-68 DOTATATE Positron Emission Tomography/Computed Tomography Imaging in Malignant Pheochromocytoma. ( 25709553 )
2015
39
Patterns of Use and Short-Term Outcomes of Minimally Invasive Surgery for Malignant Pheochromocytoma: A Population-Level Study. ( 25821949 )
2015
40
Malignant pheochromocytoma with lung metastasis after right adrenalectomy for pheochromocytoma eleven years ago. ( 25922747 )
2015
41
Malignant pheochromocytoma in the elderly: which is the best management in clinical practice? ( 26378491 )
2015
42
Clinical course and prognostic factors in patients with malignant pheochromocytoma and paraganglioma: A single institution experience. ( 26464058 )
2015
43
Flank pain after minor trauma as the initial manifestation of malignant pheochromocytoma; a case report. ( 28197483 )
2015
44
Calcific malignant pheochromocytoma. ( 24170888 )
2014
45
Sunitinib for refractory malignant pheochromocytoma: two case reports. ( 24510251 )
2014
46
In Silico Analysis Identification of a Novel Germ-Line VHL Mutation in a Patient of Malignant Pheochromocytoma. ( 24518179 )
2014
47
Malignant pheochromocytoma in a 16-year-old patient with neurofibromatosis type 1. ( 24555864 )
2014
48
A Case of Malignant Pheochromocytoma Detected during Fertility Treatment. ( 24653857 )
2014
49
Combination chemotherapy regimen in a patient with metastatic malignant pheochromocytoma and neurofibromatosis type 1. ( 24711885 )
2014
50
Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma. ( 24891137 )
2014

Variations for Malignant Pheochromocytoma

Expression for Malignant Pheochromocytoma

Search GEO for disease gene expression data for Malignant Pheochromocytoma.

Pathways for Malignant Pheochromocytoma

GO Terms for Malignant Pheochromocytoma

Biological processes related to Malignant Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to pain GO:0048265 8.32 SLC6A2

Sources for Malignant Pheochromocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....