MCID: MLG157
MIFTS: 35

Malignant Pheochromocytoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Malignant Pheochromocytoma

MalaCards integrated aliases for Malignant Pheochromocytoma:

Name: Malignant Pheochromocytoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080347

Summaries for Malignant Pheochromocytoma

Disease Ontology : 12 An adrenal medulla cancer that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones.

MalaCards based summary : Malignant Pheochromocytoma is related to paraganglioma and ganglioneuroblastoma. An important gene associated with Malignant Pheochromocytoma is SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B). The drugs Prednisolone phosphate and Prednisolone have been mentioned in the context of this disorder. Affiliated tissues include liver, bone and lung, and related phenotype is nervous system.

Related Diseases for Malignant Pheochromocytoma

Diseases in the Pheochromocytoma family:

Malignant Pheochromocytoma Sporadic Pheochromocytoma

Diseases related to Malignant Pheochromocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 208)
# Related Disease Score Top Affiliating Genes
1 paraganglioma 30.4 CHGA ENO2 SDHB SST SYP
2 ganglioneuroblastoma 30.0 ENO2 SYP
3 multiple endocrine neoplasia, type iia 29.8 CALCA SDHB
4 ganglioneuroma 29.8 CHGA ENO2 SYP
5 hemangioma 29.7 CHGA ENO2 SYP
6 pheochromocytoma 29.6 CALCA CHGA ENO2 PNMT SDHB SLC6A2
7 multiple endocrine neoplasia 29.5 CALCA CHGA PNMT SDHB
8 paragangliomas 4 11.2
9 adrenal gland pheochromocytoma 10.8
10 gastrointestinal system benign neoplasm 10.4 CHGA SST
11 serotonin syndrome 10.4 CHGA SST
12 gastrinoma 10.4 CHGA SST
13 gastrointestinal neuroendocrine benign tumor 10.4 CHGA SST
14 gastric neuroendocrine neoplasm 10.4 CHGA SST
15 paragangliomas 1 10.4 CHGA SDHB
16 pituitary carcinoma 10.4 CHGA SST
17 duodenum cancer 10.4 ENO2 SST
18 ileum cancer 10.4 ENO2 SST
19 tubular adenocarcinoma 10.3 CHGA SYP
20 glucagonoma 10.3 CHGA SST
21 gastric tubular adenocarcinoma 10.3 CHGA SYP
22 insulinomatosis and diabetes mellitus 10.3 CHGA SST
23 intracranial primitive neuroectodermal tumor 10.3 CHGA ENO2
24 ectopic cushing syndrome 10.3 SST SYP
25 colonic pseudo-obstruction 10.3 SST SYP
26 epithelioid malignant peripheral nerve sheath tumor 10.3 CHGA ENO2
27 vipoma 10.3 CHGA SST
28 goblet cell carcinoid 10.3 CHGA ENO2
29 ureter small cell carcinoma 10.3 CHGA SYP
30 mongolian spot 10.3 ENO2 SST
31 esophageal neuroendocrine tumor 10.3 CHGA SYP
32 ovarian large-cell neuroendocrine carcinoma 10.3 CHGA SYP
33 acinar cell cystadenocarcinoma 10.3 CHGA SYP
34 retroperitoneal neuroblastoma 10.3 ENO2 SST
35 peritoneal serous adenocarcinoma 10.3 CHGA SYP
36 cellular ependymoma 10.3 CHGA SYP
37 primary hepatic neuroendocrine carcinoma 10.3 CHGA SYP
38 chordoid meningioma 10.3 CHGA SYP
39 malignant glandular tumor of peripheral nerve sheath 10.3 SST SYP
40 olfactory groove meningioma 10.3 CHGA SYP
41 pancreatic serous cystadenoma 10.3 CHGA SYP
42 chondrosarcoma, extraskeletal myxoid 10.3 ENO2 SYP
43 cystadenoma 10.3 CHGA SYP
44 mixed cell type cancer 10.3 ENO2 SYP
45 conventional angiosarcoma 10.3 CHGA SYP
46 adrenal rest tumor 10.3 ENO2 SYP
47 optic nerve neoplasm 10.3 ENO2 SYP
48 medullomyoblastoma 10.3 ENO2 SYP
49 adult medulloblastoma 10.3 ENO2 SYP
50 optic nerve glioma 10.3 ENO2 SYP

Graphical network of the top 20 diseases related to Malignant Pheochromocytoma:



Diseases related to Malignant Pheochromocytoma

Symptoms & Phenotypes for Malignant Pheochromocytoma

MGI Mouse Phenotypes related to Malignant Pheochromocytoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 CHGA ENO2 LGALS3 NME1 PNMT SLC6A2

Drugs & Therapeutics for Malignant Pheochromocytoma

Drugs for Malignant Pheochromocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
2
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
3
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
5
Carbidopa Approved Phase 2 28860-95-9 34359
6
Iodine Approved, Investigational Phase 1, Phase 2,Phase 2 7553-56-2 807
7
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
8
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
9
Lenvatinib Approved, Investigational Phase 2 417716-92-8
10
Tretinoin Approved, Investigational, Nutraceutical Phase 2 302-79-4 5538 444795
11
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
12 Prednisolone acetate Phase 2
13 3-Iodobenzylguanidine Phase 2,Phase 1
14 alpha-methyltyrosine Phase 2
15 Methylprednisolone Acetate Phase 2
16 tyrosine Phase 2
17 Radiopharmaceuticals Phase 2,Phase 1
18 cadexomer iodine Phase 1, Phase 2,Phase 2
19 Angiogenesis Modulating Agents Phase 2
20 Protein Kinase Inhibitors Phase 2
21 Angiogenesis Inhibitors Phase 2
22
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
23
Racepinephrine Approved Not Applicable 329-65-7 838
24 Adrenergic Agents Not Applicable
25 Respiratory System Agents Not Applicable
26 Bronchodilator Agents Not Applicable
27 Epinephryl borate Not Applicable
28 Adrenergic alpha-Agonists Not Applicable
29 Adrenergic Agonists Not Applicable
30 Vasoconstrictor Agents Not Applicable
31 Anti-Asthmatic Agents Not Applicable
32 Autonomic Agents Not Applicable
33 Neurotransmitter Agents Not Applicable
34 Sympathomimetics Not Applicable
35 Adrenergic beta-Agonists Not Applicable
36 Peripheral Nervous System Agents Not Applicable
37 Mydriatics Not Applicable

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 131MIBG to Treat Malignant Pheochromocytoma Completed NCT00028106 Phase 2 [131]I-MIBG;6-[18F]Fluorodopamine;[123]I-MIBG
2 Phase 1 Study of Iobenguane (MIBG) I 131 in Patients With Malignant Pheochromocytoma/Paraganglioma Completed NCT00458952 Phase 1, Phase 2 Ultratrace Iobenguane (MIBG) I 131
3 Pazopanib Hydrochloride in Treating Patients With Advanced or Progressive Malignant Pheochromocytoma or Paraganglioma Terminated NCT01340794 Phase 2 Pazopanib Hydrochloride
4 Iodine I 131 Metaiodobenzylguanidine in Treating Patients With Recurrent, Progressive, or Refractory Neuroblastoma or Malignant Pheochromocytoma or Paraganglioma Recruiting NCT00107289 Phase 2
5 Dovitinib in Neuroendocrine Tumors Active, not recruiting NCT01635907 Phase 2 Dovitinib
6 Study to Evaluate the Effects of Cabozantinib in Patients With Unresectable Metastatic Pheochromocytomas and Paragangliomas Recruiting NCT02302833 Phase 2 Cabozantinib
7 First International Randomized Study in Malignant Progressive Pheochromocytoma and Paraganglioma Recruiting NCT01371201 Phase 2 Sunitinib;Placebo
8 Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma Active, not recruiting NCT01967576 Phase 2 Axitinib (AG-013736)
9 Lenvatinib in Treating Patients With Metastatic or Advanced Pheochromocytoma or Paraganglioma That Cannot Be Removed by Surgery Recruiting NCT03008369 Phase 2 Lenvatinib
10 Study Of Sunitinib In Patients With Recurrent Paraganglioma/Pheochromocytoma Completed NCT00843037 Phase 2 Sunitinib
11 ULTRATRACE Iobenguane I 131 in Patients With Malignant Pheochromocytoma, Paraganglioma, or Metastatic Carcinoid Completed NCT00339131 Phase 1 Ultratrace iobenguane I 131
12 Towards an Easy-to-use Adrenal Cancer/Tumor Identity Card Unknown status NCT02672020 Not Applicable
13 Compassionate Use of 131I-MIBG for Patients With Malignant Pheochromocytoma Available NCT01377532 131 I-Metaiodobenzylguanidine (131 I-MIBG)

Search NIH Clinical Center for Malignant Pheochromocytoma

Genetic Tests for Malignant Pheochromocytoma

Anatomical Context for Malignant Pheochromocytoma

MalaCards organs/tissues related to Malignant Pheochromocytoma:

42
Liver, Bone, Lung, Breast, Adrenal Gland, Brain, Colon

Publications for Malignant Pheochromocytoma

Articles related to Malignant Pheochromocytoma:

(show top 50) (show all 289)
# Title Authors Year
1
Prognosis of malignant pheochromocytoma and paraganglioma (MAPP-Prono study): an ENS@T retrospective study. ( 30715419 )
2019
2
Expression of PDK1 in malignant pheochromocytoma as a new promising potential therapeutic target. ( 30759304 )
2019
3
Takotsubo syndrome induced by malignant pheochromocytoma in a patient with type 2 papillary renal cell carcinoma - a case report. ( 29785166 )
2018
4
Recent advances in the management of malignant pheochromocytoma and paraganglioma: focus on tyrosine kinase and hypoxia-inducible factor inhibitors. ( 30109021 )
2018
5
Temozolomide treatment of a malignant pheochromocytoma and an unresectable MAX-related paraganglioma. ( 29099418 )
2018
6
Propofol Prevents the Progression of Malignant Pheochromocytoma In Vitro and In Vivo. ( 29565198 )
2018
7
131-I MIBG therapy of malignant pheochromocytoma and paraganglioma tumours - a single-centre study. ( 29645065 )
2018
8
Giant malignant pheochromocytoma in an elderly patient: A case report. ( 29742697 )
2018
9
What determines mortality in malignant pheochromocytoma? - Report of a case with eighteen-year survival and review of the literature. ( 29768630 )
2018
10
Successful treatment of malignant pheochromocytoma with sacrum metastases: A case report. ( 30170467 )
2018
11
Malignant Pheochromocytoma with Widespread Bony and Pulmonary Metastases. ( 30483454 )
2018
12
DNA methylation analysis in malignant pheochromocytoma and paraganglioma. ( 29067245 )
2017
13
Malignant pheochromocytoma in the anterior mediastinum with sternal invasion: a case report. ( 28449504 )
2017
14
Surgical Treatment of Malignant Pheochromocytoma and Paraganglioma: Retrospective Case Series. ( 28058556 )
2017
15
NVP-AUY922, a novel HSP90 inhibitor, inhibits the progression of malignant pheochromocytoma in vitro and in vivo. ( 28458565 )
2017
16
A Case of Malignant Pheochromocytoma Presenting 7 Years After the Initial Surgery. ( 28331462 )
2017
17
Perioperative Management of Adrenalectomy and Inferior Vena Cava Reconstruction in a Patient With a Large, Malignant Pheochromocytoma With Vena Caval Extension. ( 27810406 )
2017
18
Malignant pheochromocytoma-paraganglioma: pathogenesis, TNM staging, and current clinical trials. ( 28234804 )
2017
19
SDHB mutation carriers with malignant pheochromocytoma respond better to CVD. ( 28566531 )
2017
20
Malignant Pheochromocytoma and Paraganglioma: 272 Patients Over 55 Years. ( 28605453 )
2017
21
Aggressive Imaging Features in a Malignant Pheochromocytoma With a Novel Mutation of the SDHB Gene. ( 28650885 )
2017
22
Phase II trial of pazopanib in advanced/progressive malignant pheochromocytoma and paraganglioma. ( 28685225 )
2017
23
A malignant pheochromocytoma in a child with von Hippel-Lindau mutation. ( 28781534 )
2017
24
Recurrent Malignant Pheochromocytoma with Lymph Nodal Metastasis in a Child: A Rare Case. ( 28974878 )
2017
25
Proteasome Inhibitors: A Potential Medical Therapy for Malignant Pheochromocytoma. ( 28977615 )
2017
26
Malignant pheochromocytoma with multiple vertebral metastases causing acute incomplete paralysis during pregnancy: Literature review with one case report. ( 29095319 )
2017
27
Giant multicystic malignant pheochromocytoma. ( 29260138 )
2017
28
ATRX driver mutation in a composite malignant pheochromocytoma. ( 27209355 )
2016
29
Complex MAX Rearrangement in a Family With Malignant Pheochromocytoma, Renal Oncocytoma, and Erythrocytosis. ( 26670126 )
2016
30
Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma. ( 27007161 )
2016
31
Patterns of Use and Short-Term Outcomes of Minimally Invasive Surgery for Malignant Pheochromocytoma: A Population-Level Study. ( 26675927 )
2016
32
Patterns of Use and Short-Term Outcomes of Minimally Invasive Surgery for Malignant Pheochromocytoma: A Population-Level Study: Reply. ( 26791742 )
2016
33
Clinical course and prognostic factors in patients with malignant pheochromocytoma and paraganglioma: A single institution experience. ( 26464058 )
2015
34
Patterns of Use and Short-Term Outcomes of Minimally Invasive Surgery for Malignant Pheochromocytoma: A Population-Level Study. ( 25821949 )
2015
35
Targeting of mTORC2 may have advantages over selective targeting of mTORC1 in the treatment of malignant pheochromocytoma. ( 25666752 )
2015
36
Breast Metastasis Detected on Ga-68 DOTATATE Positron Emission Tomography/Computed Tomography Imaging in Malignant Pheochromocytoma. ( 25709553 )
2015
37
Malignant pheochromocytoma with lung metastasis after right adrenalectomy for pheochromocytoma eleven years ago. ( 25922747 )
2015
38
Malignant pheochromocytoma in the elderly: which is the best management in clinical practice? ( 26378491 )
2015
39
Flank pain after minor trauma as the initial manifestation of malignant pheochromocytoma; a case report. ( 28197483 )
2015
40
Incidentally Detected Inoperable Malignant Pheochromocytoma with Hepatic Metastasis Treated by Transcatheter Arterial Chemoembolization. ( 25325276 )
2014
41
Recurrent malignant pheochromocytoma with unusual omental metastasis: (68)Ga-DOTANOC PET/CT and (131)I-MIBG SPECT/CT scintigraphy findings. ( 25400380 )
2014
42
Sunitinib for refractory malignant pheochromocytoma: two case reports. ( 24510251 )
2014
43
In Silico Analysis Identification of a Novel Germ-Line VHL Mutation in a Patient of Malignant Pheochromocytoma. ( 24518179 )
2014
44
Malignant pheochromocytoma in a 16-year-old patient with neurofibromatosis type 1. ( 24555864 )
2014
45
A Case of Malignant Pheochromocytoma Detected during Fertility Treatment. ( 24653857 )
2014
46
Combination chemotherapy regimen in a patient with metastatic malignant pheochromocytoma and neurofibromatosis type 1. ( 24711885 )
2014
47
Therapy of endocrine disease: treatment of malignant pheochromocytoma and paraganglioma. ( 24891137 )
2014
48
Malignant pheochromocytoma secreting vasoactive intestinal peptide and response to sunitinib: a case report and literature review. ( 24936559 )
2014
49
External beam radiation therapy in treatment of malignant pheochromocytoma and paraganglioma. ( 25019060 )
2014
50
Giant malignant pheochromocytoma with palpable rib metastases. ( 25152826 )
2014

Variations for Malignant Pheochromocytoma

Expression for Malignant Pheochromocytoma

Search GEO for disease gene expression data for Malignant Pheochromocytoma.

Pathways for Malignant Pheochromocytoma

GO Terms for Malignant Pheochromocytoma

Biological processes related to Malignant Pheochromocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to pain GO:0048265 8.62 CALCA SLC6A2

Sources for Malignant Pheochromocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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