MCID: MLG078
MIFTS: 22

Malignant Pineal Area Germ Cell Neoplasm

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Malignant Pineal Area Germ Cell Neoplasm

MalaCards integrated aliases for Malignant Pineal Area Germ Cell Neoplasm:

Name: Malignant Pineal Area Germ Cell Neoplasm 12 15
Pineal Germ Cell Tumor 12 53 72
Malignant Pineal Parenchymal Germ Cell Tumor 12
Malignant Pineal Region Germ Cell Tumor 72
Pineal Region Germ Cell Tumor 12
Pineal Region Germinoma 53
Pineal Cell Tumour 53
Pineal Cell Tumor 53
Pineal Germinoma 72

Classifications:



External Ids:

Disease Ontology 12 DOID:1660
NCIt 50 C4659 C6767
UMLS 72 C0349621 C0854912 C1334612

Summaries for Malignant Pineal Area Germ Cell Neoplasm

MalaCards based summary : Malignant Pineal Area Germ Cell Neoplasm, also known as pineal germ cell tumor, is related to endodermal sinus tumor and malignant teratoma. An important gene associated with Malignant Pineal Area Germ Cell Neoplasm is RUNDC3A (RUN Domain Containing 3A), and among its related pathways/superpathways is Lysosome. Affiliated tissues include pineal.

Related Diseases for Malignant Pineal Area Germ Cell Neoplasm

Diseases related to Malignant Pineal Area Germ Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 endodermal sinus tumor 30.2 SALL4 AFP
2 malignant teratoma 29.8 SALL4 AFP
3 testicular yolk sac tumor 29.6 SALL4 CEACAM5 AFP
4 germ cells tumors 10.5
5 germinoma 10.4
6 teratoma 10.4
7 embryonal carcinoma 10.3
8 choriocarcinoma 10.2
9 rectum adenocarcinoma 10.2 RUNDC3A CEACAM5
10 mature teratoma 10.2
11 intracranial hypertension 10.2
12 mucinous cystadenofibroma 10.2 CEACAM5 AFP
13 liver lymphoma 10.2 CEACAM5 AFP
14 urachal adenocarcinoma 10.1 CEACAM5 AFP
15 melanotic medulloblastoma 10.1 CEACAM5 AFP
16 pancreatic cystadenocarcinoma 10.1 CEACAM5 AFP
17 bile duct cystadenocarcinoma 10.1 CEACAM5 AFP
18 liver sarcoma 10.1 CEACAM5 AFP
19 rete testis adenocarcinoma 10.1 CEACAM5 AFP
20 precocious puberty 10.1
21 obstructive hydrocephalus 10.1
22 pineoblastoma 10.1
23 brain germinoma 10.1
24 neurilemmoma 10.1
25 central nervous system germinoma 10.1
26 pineal gland cancer 10.1
27 hypopituitarism 10.1
28 pineocytoma 10.1
29 back pain 10.1
30 rete testis neoplasm 10.0 CEACAM5 AFP
31 pallister-killian syndrome 10.0
32 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.0
33 hydrocephalus 10.0
34 germ cell cancer 10.0
35 pineal region germinoma 10.0
36 diabetes insipidus 10.0
37 congenital hydrocephalus 10.0
38 epidermolysis bullosa, junctional, herlitz type 10.0 CEACAM5 AFP
39 mixed cell type cancer 10.0 CEACAM5 AFP
40 bile duct adenocarcinoma 10.0 CEACAM5 AFP
41 tracheal cancer 9.9 CEACAM5 AFP
42 bile duct disease 9.9 CEACAM5 AFP
43 ovarian germ cell cancer 9.9 SALL4 AFP
44 medulloblastoma 9.8
45 biliary tract disease 9.8 CEACAM5 AFP
46 gastrointestinal system disease 9.8 CEACAM5 AFP
47 embryoma 9.8 SALL4 AFP
48 ovarian endodermal sinus tumor 9.8 SALL4 AFP
49 ovarian primitive germ cell tumor 9.7 SALL4 AFP
50 gastrointestinal system cancer 9.7 CEACAM5 AFP

Graphical network of the top 20 diseases related to Malignant Pineal Area Germ Cell Neoplasm:



Diseases related to Malignant Pineal Area Germ Cell Neoplasm

Symptoms & Phenotypes for Malignant Pineal Area Germ Cell Neoplasm

Drugs & Therapeutics for Malignant Pineal Area Germ Cell Neoplasm

Search Clinical Trials , NIH Clinical Center for Malignant Pineal Area Germ Cell Neoplasm

Genetic Tests for Malignant Pineal Area Germ Cell Neoplasm

Anatomical Context for Malignant Pineal Area Germ Cell Neoplasm

MalaCards organs/tissues related to Malignant Pineal Area Germ Cell Neoplasm:

41
Pineal

Publications for Malignant Pineal Area Germ Cell Neoplasm

Articles related to Malignant Pineal Area Germ Cell Neoplasm:

(show all 11)
# Title Authors PMID Year
1
Assessing therapy response of secreting pineal germ cell tumor on simultaneous 18F-choline PET/MRI. 38
24217533 2014
2
Pineal germ cell tumors: review. 38
23528168 2013
3
Reversible hearing loss associated with a malignant pineal germ cell tumor. Case report. 38
12959450 2003
4
Pineal germ cell tumor metastasis via ventriculoperitoneal shunt. 38
11823710 2002
5
Pseudo-precocious puberty in a male patient and the melatonin-testosterone relationship. 38
8821909 1995
6
Diabetes insipidus as an early sign of pineal tumor. 38
7537449 1995
7
Isochromosome 12p-positive pineal germ cell tumor. 38
8137260 1994
8
Oncologic causes of precocious puberty. 38
2701702 1989
9
[Spinal metastasis detected 11 years after initial treatment for pineal germ cell tumor. Case report]. 38
2471105 1988
10
Successful combination chemotherapy (cisplatinum, vinblastine, and bleomycin) against peritoneal dissemination of intracranial germ cell tumor. 38
2426626 1986
11
Extraneural metastasis of choriocarcinomatous element in pineal germ-cell tumor. Case report. 38
2410581 1985

Variations for Malignant Pineal Area Germ Cell Neoplasm

Expression for Malignant Pineal Area Germ Cell Neoplasm

Search GEO for disease gene expression data for Malignant Pineal Area Germ Cell Neoplasm.

Pathways for Malignant Pineal Area Germ Cell Neoplasm

Pathways related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.71 NPC2 ASAH1

GO Terms for Malignant Pineal Area Germ Cell Neoplasm

Cellular components related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lysosomal lumen GO:0043202 8.62 NPC2 ASAH1

Sources for Malignant Pineal Area Germ Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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