MCID: MLG078
MIFTS: 26

Malignant Pineal Area Germ Cell Neoplasm

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Malignant Pineal Area Germ Cell Neoplasm

MalaCards integrated aliases for Malignant Pineal Area Germ Cell Neoplasm:

Name: Malignant Pineal Area Germ Cell Neoplasm 12 15
Pineal Germ Cell Tumor 12 53 73
Malignant Pineal Parenchymal Germ Cell Tumor 12
Malignant Pineal Region Germ Cell Tumor 73
Pineal Region Germ Cell Tumor 12
Pineal Region Germinoma 53
Pineal Cell Tumour 53
Pineal Cell Tumor 53
Pineal Germinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1660
NCIt 50 C4659 C6767

Summaries for Malignant Pineal Area Germ Cell Neoplasm

MalaCards based summary : Malignant Pineal Area Germ Cell Neoplasm, also known as pineal germ cell tumor, is related to pineal region germinoma and germ cells tumors. An important gene associated with Malignant Pineal Area Germ Cell Neoplasm is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include pineal and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Malignant Pineal Area Germ Cell Neoplasm

Graphical network of the top 20 diseases related to Malignant Pineal Area Germ Cell Neoplasm:



Diseases related to Malignant Pineal Area Germ Cell Neoplasm

Symptoms & Phenotypes for Malignant Pineal Area Germ Cell Neoplasm

GenomeRNAi Phenotypes related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.16 IGF1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.16 AFP IGF1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.16 AFP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.16 IGF1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.16 IGF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.16 IGF1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.16 IGF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.16 IGF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.16 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.16 IGF1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.16 IGF1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.16 AFP IGF1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.16 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.16 IGF1
15 Reduced mammosphere formation GR00396-S 8.8 AFP CD34 IGF1

MGI Mouse Phenotypes related to Malignant Pineal Area Germ Cell Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 AFP CD34 IGF1

Drugs & Therapeutics for Malignant Pineal Area Germ Cell Neoplasm

Search Clinical Trials , NIH Clinical Center for Malignant Pineal Area Germ Cell Neoplasm

Genetic Tests for Malignant Pineal Area Germ Cell Neoplasm

Anatomical Context for Malignant Pineal Area Germ Cell Neoplasm

MalaCards organs/tissues related to Malignant Pineal Area Germ Cell Neoplasm:

41
Pineal, Liver

Publications for Malignant Pineal Area Germ Cell Neoplasm

Articles related to Malignant Pineal Area Germ Cell Neoplasm:

# Title Authors Year
1
Assessing therapy response of secreting pineal germ cell tumor on simultaneous 18F-choline PET/MRI. ( 24217533 )
2014
2
Reversible hearing loss associated with a malignant pineal germ cell tumor. Case report. ( 12959450 )
2003
3
Pineal germ cell tumor metastasis via ventriculoperitoneal shunt. ( 11823710 )
2002
4
Isochromosome 12p-positive pineal germ cell tumor. ( 8137260 )
1994
5
Extraneural metastasis of choriocarcinomatous element in pineal germ-cell tumor. Case report. ( 2410581 )
1985

Variations for Malignant Pineal Area Germ Cell Neoplasm

Expression for Malignant Pineal Area Germ Cell Neoplasm

Search GEO for disease gene expression data for Malignant Pineal Area Germ Cell Neoplasm.

Pathways for Malignant Pineal Area Germ Cell Neoplasm

Pathways related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 AFP IGF1

GO Terms for Malignant Pineal Area Germ Cell Neoplasm

Cellular components related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 8.8 AFP CD34 IGF1

Biological processes related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.26 CD34 IGF1
2 cell proliferation GO:0008283 9.16 CD34 IGF1
3 negative regulation of gene expression GO:0010629 8.96 CD34 IGF1
4 cellular protein metabolic process GO:0044267 8.62 AFP IGF1

Sources for Malignant Pineal Area Germ Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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