MCID: MLG078
MIFTS: 28

Malignant Pineal Area Germ Cell Neoplasm

Categories: Rare diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Malignant Pineal Area Germ Cell Neoplasm

MalaCards integrated aliases for Malignant Pineal Area Germ Cell Neoplasm:

Name: Malignant Pineal Area Germ Cell Neoplasm 12 15
Pineal Germ Cell Tumor 12 53 73
Malignant Pineal Parenchymal Germ Cell Tumor 12
Malignant Pineal Region Germ Cell Tumor 73
Pineal Region Germ Cell Tumor 12
Pineal Region Germinoma 53
Pineal Cell Tumour 53
Pineal Cell Tumor 53
Pineal Germinoma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1660
NCIt 50 C4659 C6767
SNOMED-CT 68 277508009

Summaries for Malignant Pineal Area Germ Cell Neoplasm

MalaCards based summary : Malignant Pineal Area Germ Cell Neoplasm, also known as pineal germ cell tumor, is related to pineal region germinoma and germ cells tumors. An important gene associated with Malignant Pineal Area Germ Cell Neoplasm is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Tremelimumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include pineal, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Malignant Pineal Area Germ Cell Neoplasm

Diseases related to Malignant Pineal Area Germ Cell Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 pineal region germinoma 12.5
2 germ cells tumors 10.3
3 teratoma 10.0
4 mature teratoma 10.0
5 diabetes insipidus 9.9
6 ovarian solid teratoma 9.9 AFP CD34
7 sternum cancer 9.9 AFP CD34
8 liver inflammatory pseudotumor 9.8 AFP CD34
9 chorioangioma 9.8 AFP CD34
10 hemangioma of intra-abdominal structure 9.8 AFP CD34
11 pineal region choriocarcinoma 9.7 CD34 IGF1
12 cell type cancer 9.7 AFP CD34
13 gastrointestinal system cancer 9.6 AFP CD34
14 organ system benign neoplasm 9.5 CD34 IGF1
15 cell type benign neoplasm 9.5 CD34 IGF1
16 myeloma, multiple 9.2 CD34 IGF1
17 ewing sarcoma 9.0 CD34 IGF1

Graphical network of the top 20 diseases related to Malignant Pineal Area Germ Cell Neoplasm:



Diseases related to Malignant Pineal Area Germ Cell Neoplasm

Symptoms & Phenotypes for Malignant Pineal Area Germ Cell Neoplasm

GenomeRNAi Phenotypes related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.16 IGF1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.16 AFP IGF1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.16 AFP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.16 IGF1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.16 IGF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.16 IGF1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.16 IGF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.16 IGF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.16 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.16 IGF1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.16 IGF1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.16 IGF1 AFP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.16 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.16 IGF1
15 Reduced mammosphere formation GR00396-S 8.8 CD34 IGF1 AFP

MGI Mouse Phenotypes related to Malignant Pineal Area Germ Cell Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 CD34 IGF1 AFP

Drugs & Therapeutics for Malignant Pineal Area Germ Cell Neoplasm

Drugs for Malignant Pineal Area Germ Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tremelimumab Investigational Phase 2 745013-59-6
2 Antibodies Phase 2
3 Antibodies, Monoclonal Phase 2
4 Immunoglobulins Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors Recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab

Search NIH Clinical Center for Malignant Pineal Area Germ Cell Neoplasm

Genetic Tests for Malignant Pineal Area Germ Cell Neoplasm

Anatomical Context for Malignant Pineal Area Germ Cell Neoplasm

MalaCards organs/tissues related to Malignant Pineal Area Germ Cell Neoplasm:

41
Pineal

Publications for Malignant Pineal Area Germ Cell Neoplasm

Articles related to Malignant Pineal Area Germ Cell Neoplasm:

# Title Authors Year
1
Pineal germ cell tumors: review. ( 23528168 )
2013
2
Spontaneous regression of germinoma in the pineal region before endoscopic surgery: a pitfall of modern strategy for pineal germ cell tumors. ( 20949306 )
2011
3
Pineal germ cell tumors. ( 19329862 )
2009
4
Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries. ( 18287340 )
2008
5
Simultaneous suprasellar and pineal germ cell tumors in five late stage adolescents: endocrinological studies and prolonged follow-up. ( 19189691 )
2008
6
Management of malignant pineal germ cell tumors with residual mature teratoma. ( 11865805 )
2001
7
Management of malignant pineal germ cell tumors with residual mature teratoma. ( 11270541 )
2001

Variations for Malignant Pineal Area Germ Cell Neoplasm

Expression for Malignant Pineal Area Germ Cell Neoplasm

Search GEO for disease gene expression data for Malignant Pineal Area Germ Cell Neoplasm.

Pathways for Malignant Pineal Area Germ Cell Neoplasm

Pathways related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 AFP IGF1

GO Terms for Malignant Pineal Area Germ Cell Neoplasm

Cellular components related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 8.8 AFP CD34 IGF1

Biological processes related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.16 CD34 IGF1
2 cell proliferation GO:0008283 8.96 CD34 IGF1
3 cellular protein metabolic process GO:0044267 8.62 AFP IGF1

Sources for Malignant Pineal Area Germ Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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