MCID: MLG078
MIFTS: 29

Malignant Pineal Area Germ Cell Neoplasm

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Malignant Pineal Area Germ Cell Neoplasm

MalaCards integrated aliases for Malignant Pineal Area Germ Cell Neoplasm:

Name: Malignant Pineal Area Germ Cell Neoplasm 12 15
Pineal Germ Cell Tumor 12 54 74
Malignant Pineal Parenchymal Germ Cell Tumor 12
Malignant Pineal Region Germ Cell Tumor 74
Pineal Region Germ Cell Tumor 12
Pineal Region Germinoma 54
Pineal Cell Tumour 54
Pineal Cell Tumor 54
Pineal Germinoma 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1660
NCIt 51 C4659 C6767

Summaries for Malignant Pineal Area Germ Cell Neoplasm

MalaCards based summary : Malignant Pineal Area Germ Cell Neoplasm, also known as pineal germ cell tumor, is related to pineal region germinoma and germ cells tumors. An important gene associated with Malignant Pineal Area Germ Cell Neoplasm is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Durvalumab and Tremelimumab have been mentioned in the context of this disorder. Affiliated tissues include pineal, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Malignant Pineal Area Germ Cell Neoplasm

Graphical network of the top 20 diseases related to Malignant Pineal Area Germ Cell Neoplasm:



Diseases related to Malignant Pineal Area Germ Cell Neoplasm

Symptoms & Phenotypes for Malignant Pineal Area Germ Cell Neoplasm

GenomeRNAi Phenotypes related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

27 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 10.19 IGF1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 10.19 AFP IGF1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-120 10.19 AFP
4 Increased shRNA abundance (Z-score > 2) GR00366-A-138 10.19 IGF1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-161 10.19 IGF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 10.19 IGF1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-164 10.19 IGF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.19 IGF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-192 10.19 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 10.19 IGF1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 10.19 IGF1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.19 AFP IGF1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.19 AFP
14 Increased shRNA abundance (Z-score > 2) GR00366-A-65 10.19 AFP
15 Increased shRNA abundance (Z-score > 2) GR00366-A-99 10.19 IGF1
16 Reduced mammosphere formation GR00396-S 8.8 AFP CD34 IGF1

MGI Mouse Phenotypes related to Malignant Pineal Area Germ Cell Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.8 AFP CD34 IGF1

Drugs & Therapeutics for Malignant Pineal Area Germ Cell Neoplasm

Drugs for Malignant Pineal Area Germ Cell Neoplasm (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Durvalumab Approved, Investigational Phase 2 1428935-60-7
2
Tremelimumab Investigational Phase 2 745013-59-6
3 Immunoglobulins Phase 2
4 Antibodies, Monoclonal Phase 2
5 Antineoplastic Agents, Immunological Phase 2
6 Antibodies Phase 2
7 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluating Immune Therapy, Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors Active, not recruiting NCT03158064 Phase 2 Durvalumab;Tremelimumab

Search NIH Clinical Center for Malignant Pineal Area Germ Cell Neoplasm

Genetic Tests for Malignant Pineal Area Germ Cell Neoplasm

Anatomical Context for Malignant Pineal Area Germ Cell Neoplasm

MalaCards organs/tissues related to Malignant Pineal Area Germ Cell Neoplasm:

42
Pineal

Publications for Malignant Pineal Area Germ Cell Neoplasm

Articles related to Malignant Pineal Area Germ Cell Neoplasm:

# Title Authors Year
1
Assessing therapy response of secreting pineal germ cell tumor on simultaneous 18F-choline PET/MRI. ( 24217533 )
2014
2
Reversible hearing loss associated with a malignant pineal germ cell tumor. Case report. ( 12959450 )
2003
3
Pineal germ cell tumor metastasis via ventriculoperitoneal shunt. ( 11823710 )
2002
4
Isochromosome 12p-positive pineal germ cell tumor. ( 8137260 )
1994
5
Extraneural metastasis of choriocarcinomatous element in pineal germ-cell tumor. Case report. ( 2410581 )
1985

Variations for Malignant Pineal Area Germ Cell Neoplasm

Expression for Malignant Pineal Area Germ Cell Neoplasm

Search GEO for disease gene expression data for Malignant Pineal Area Germ Cell Neoplasm.

Pathways for Malignant Pineal Area Germ Cell Neoplasm

Pathways related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 AFP IGF1

GO Terms for Malignant Pineal Area Germ Cell Neoplasm

Cellular components related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 8.8 AFP CD34 IGF1

Biological processes related to Malignant Pineal Area Germ Cell Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.26 CD34 IGF1
2 cell proliferation GO:0008283 9.16 CD34 IGF1
3 negative regulation of gene expression GO:0010629 8.96 CD34 IGF1
4 cellular protein metabolic process GO:0044267 8.62 AFP IGF1

Sources for Malignant Pineal Area Germ Cell Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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