MCID: MLG003
MIFTS: 33

Malignant Renovascular Hypertension

Categories: Cancer diseases, Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Malignant Renovascular Hypertension

MalaCards integrated aliases for Malignant Renovascular Hypertension:

Name: Malignant Renovascular Hypertension 12 15
Secondary Malignant Renovascular Hypertension 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13730
UMLS 70 C0264643

Summaries for Malignant Renovascular Hypertension

MalaCards based summary : Malignant Renovascular Hypertension, also known as secondary malignant renovascular hypertension, is related to renovascular hypertension and malignant hypertension. An important gene associated with Malignant Renovascular Hypertension is REN (Renin), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Related phenotypes are cardiovascular system and growth/size/body region

Related Diseases for Malignant Renovascular Hypertension

Diseases in the Renovascular Hypertension family:

Benign Renovascular Hypertension Malignant Renovascular Hypertension

Diseases related to Malignant Renovascular Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 renovascular hypertension 30.8 REN EDN1 AGTR1
2 malignant hypertension 30.4 REN EDN1 AGTR1
3 aortic aneurysm, familial abdominal, 1 30.0 SERPINE1 REN AGTR1
4 kidney papillary necrosis 10.3 REN EDN1
5 femoral cancer 10.3 EDNRA EDN1
6 pulmonary valve insufficiency 10.3 REN EDN1
7 acquired color blindness 10.3 EDNRA EDN1
8 generalized atherosclerosis 10.3 SERPINE1 REN
9 transient refractive change 10.3 EDNRA EDN1
10 mandibulofacial dysostosis with alopecia 10.3 EDNRA EDN1
11 anhidrosis, isolated, with normal sweat glands 10.3 EDNRA EDN1
12 nephrogenic systemic fibrosis 10.3 EDNRA EDN1
13 idiopathic hypercalciuria 10.3 REN EDN1
14 coronary artery vasospasm 10.2 REN EDN1
15 tricuspid valve disease 10.2 REN EDN1
16 chronic pulmonary heart disease 10.2 EDNRA EDN1
17 perinephritis 10.2 REN EDNRA EDN1
18 tricuspid valve insufficiency 10.2 REN EDNRA EDN1
19 severe nonproliferative diabetic retinopathy 10.2 REN PGF
20 intracranial berry aneurysm 10.2 REN EDNRA EDN1
21 hypertensive retinopathy 10.2 REN AGTR1
22 mitral valve stenosis 10.2 REN EDN1
23 fibromuscular dysplasia 10.2 REN AGTR1
24 apnea, obstructive sleep 10.2 SERPINE1 REN EDN1
25 hepatic vascular disease 10.2 SERPINE1 REN EDN1
26 renal artery disease 10.1 REN AGTR1
27 sleep apnea 10.1 SERPINE1 REN EDN1
28 lipodermatosclerosis 10.1 ANGPT2 ANGPT1
29 familial hypertension 10.1 REN AGTR1
30 diaphragm disease 10.1 EDNRA EDN1
31 macrophage activation syndrome 10.1 ANGPT2 ANGPT1
32 vitreous detachment 10.1 VEGFB PGF
33 acute mountain sickness 10.1 EDN1 AGTR1
34 anuria 10.1 REN AGTR1
35 retinal perforation 10.1 VEGFB PGF
36 blood group, globoside system 10.1 VEGFB PGF
37 myocardial stunning 10.1 EDN1 AGTR1
38 retinal vein occlusion 10.1 SERPINE1 EDN1 ANGPT2
39 eclampsia 10.0 REN PGF EDN1
40 raynaud disease 10.0 EDNRA EDN1 AGTR1
41 renal hypertension 10.0 REN EDN1 AGTR1
42 ureteral disease 10.0 SERPINE1 REN AGTR1
43 persistent fetal circulation syndrome 10.0 PGF EDNRA EDN1
44 microvascular complications of diabetes 3 10.0 REN AGTR1
45 orthostatic intolerance 10.0 REN EDN1 AGTR1
46 portal hypertension 10.0 EDNRA EDN1 AGTR1
47 patent foramen ovale 10.0 SERPINE1 REN EDNRA EDN1
48 endophthalmitis 10.0 VEGFB PGF
49 arteriosclerosis 10.0 SERPINE1 EDNRA EDN1
50 renal fibrosis 10.0 SERPINE1 REN AGTR1

Comorbidity relations with Malignant Renovascular Hypertension via Phenotypic Disease Network (PDN): (show all 12)


Acute Cystitis Acute Kidney Failure
Chronic Kidney Disease Deficiency Anemia
Heart Disease Hypertension, Essential
Hypertensive Encephalopathy Intermediate Coronary Syndrome
Malignant Essential Hypertension Peripheral Vascular Disease
Renal Artery Atheroma Renal Artery Disease

Graphical network of the top 20 diseases related to Malignant Renovascular Hypertension:



Diseases related to Malignant Renovascular Hypertension

Symptoms & Phenotypes for Malignant Renovascular Hypertension

MGI Mouse Phenotypes related to Malignant Renovascular Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.21 AGTR1 ANGPT1 ANGPT2 EDN1 EDNRA PGF
2 growth/size/body region MP:0005378 10.15 AGTR1 ANGPT1 EDN1 EDNRA PGF RAD51
3 homeostasis/metabolism MP:0005376 10.1 AGTR1 ANGPT1 ANGPT2 EDN1 EDNRA PGF
4 embryo MP:0005380 9.95 ANGPT1 EDN1 EDNRA PGF RAD51 TEK
5 mortality/aging MP:0010768 9.93 AGTR1 ANGPT1 ANGPT2 EDN1 EDNRA RAD51
6 immune system MP:0005387 9.91 AGTR1 ANGPT1 ANGPT2 EDNRA PGF REN
7 muscle MP:0005369 9.43 ANGPT1 EDN1 EDNRA REN TEK TIE1
8 renal/urinary system MP:0005367 9.17 AGTR1 ANGPT1 EDN1 EDNRA REN SERPINE1

Drugs & Therapeutics for Malignant Renovascular Hypertension

Search Clinical Trials , NIH Clinical Center for Malignant Renovascular Hypertension

Genetic Tests for Malignant Renovascular Hypertension

Anatomical Context for Malignant Renovascular Hypertension

Publications for Malignant Renovascular Hypertension

Articles related to Malignant Renovascular Hypertension:

(show all 17)
# Title Authors PMID Year
1
Mid-Aortic Syndrome: A Rare Cause of Renovascular Hypertension in Childhood Treated Percutaneously with an Unusual Vascular Access. 61
32516103 2020
2
Impaired Neovascularization and Reduced Capillary Supply in the Malignant vs. Non-malignant Course of Experimental Renovascular Hypertension. 61
27625610 2016
3
When the chimney is blocked: malignant renovascular hypertension after endovascular repair of abdominal aortic aneurysm. 61
23531087 2013
4
Endovascular therapy of renovascular hypertension in children: single center analysis. 61
19360546 2009
5
[Case report: neonatal hypertension]. 61
12424682 2002
6
Midaortic syndrome in childhood associated with a ruptured cerebral aneurysm: a case report. 61
11358589 2001
7
Plasma-levels of endothelin-1 and angiotensin-II and reactivity of arterial blood pressure to exogenous sympathomimetics and vasoactive peptides in rat model of malignant renal hypertension. 61
10870254 2000
8
Endovascular treatment of renal artery thrombosis caused by umbilical artery catheterization. 61
9808866 1998
9
[Malignant renovascular hypertension and unilateral obstruction of the renal artery. Value of emergency percutaneous renal angioplasty]. 61
1386452 1992
10
Predominant right ventricular infarction in malignant renovascular hypertension in rats. 61
3598333 1987
11
[Reproducibility of acute captopril-induced renal insufficiency with enalapril]. 61
6321850 1984
12
[Hyponatremia in malignant renovascular hypertension]. 61
6646736 1983
13
Control of malignant renovascular hypertension by percutaneous transluminal angioplasty and therapeutic renal embolization. 61
6767370 1980
14
[Malignant renovascular hypertension caused by intraparenchymal anomalies of the left renal artery with lack of contralateral renin suppression. Cure by nephrectomy]. 61
400172 1979
15
Renin-angiotensin system in an infant with malignant renovascular hypertension. 61
939701 1976
16
Changes of plasma renin, angiotensin II and renin substrate during reversal of malignant renovascular hypertension. 61
1206969 1975
17
Malignant renovascular hypertension in a newborn. 61
5956765 1966

Variations for Malignant Renovascular Hypertension

Expression for Malignant Renovascular Hypertension

Search GEO for disease gene expression data for Malignant Renovascular Hypertension.

Pathways for Malignant Renovascular Hypertension

Pathways related to Malignant Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.98 VEGFD VEGFB TEK SERPINE1 PGF EDNRA
2
Show member pathways
13.66 VEGFD VEGFB TIE1 TEK RAD51 PGF
3
Show member pathways
13.36 VEGFD VEGFB TIE1 TEK PGF ANGPT2
4
Show member pathways
13.26 VEGFD VEGFB TIE1 TEK PGF ANGPT2
5
Show member pathways
13.16 VEGFD VEGFB TEK SERPINE1 ANGPT2 ANGPT1
6
Show member pathways
13.15 VEGFD VEGFB TIE1 TEK PGF ANGPT2
7
Show member pathways
12.89 VEGFD VEGFB REN PGF AGTR1
8
Show member pathways
12.86 VEGFD VEGFB TEK PGF ANGPT2 ANGPT1
9 12.6 VEGFD VEGFB TEK PGF ANGPT2 ANGPT1
10
Show member pathways
12.56 VEGFD VEGFB TEK PGF ANGPT2 ANGPT1
11 12.42 VEGFD VEGFB RAD51 PGF EDNRA EDN1
12
Show member pathways
12.38 TIE1 TEK RAD51 ANGPT2 ANGPT1 AGTR1
13 12.28 VEGFD VEGFB EDNRA AGTR1
14
Show member pathways
12.27 VEGFD VEGFB TIE1 TEK PGF
15
Show member pathways
12.05 TEK ANGPT2 ANGPT1
16 12.03 VEGFB TIE1 TEK ANGPT2
17 11.75 VEGFB TEK REN ANGPT2
18 11.54 REN EDNRA EDN1 AGTR1
19 11.49 VEGFD VEGFB EDN1
20 11.39 TEK SERPINE1 EDN1 ANGPT2 ANGPT1
21 11.13 SERPINE1 EDN1 ANGPT2 ANGPT1
22 11.11 EDNRA EDN1
23 11.08 SERPINE1 ANGPT2 AGTR1
24
Show member pathways
11.04 EDNRA EDN1
25 11.02 VEGFD VEGFB SERPINE1 EDN1 AGTR1
26 11 TEK ANGPT1
27
Show member pathways
10.86 VEGFD VEGFB PGF
28 10.77 VEGFD VEGFB TIE1 TEK PGF ANGPT2

GO Terms for Malignant Renovascular Hypertension

Cellular components related to Malignant Renovascular Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 VEGFD VEGFB SERPINE1 REN PGF EDN1
2 platelet alpha granule lumen GO:0031093 9.33 VEGFD VEGFB SERPINE1
3 extracellular region GO:0005576 9.28 VEGFD VEGFB TEK SERPINE1 REN PGF

Biological processes related to Malignant Renovascular Hypertension according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.18 VEGFB TIE1 TEK PGF EDNRA ANGPT2
2 multicellular organism development GO:0007275 10.09 VEGFD TIE1 TEK PGF ANGPT2 ANGPT1
3 response to drug GO:0042493 9.92 VEGFB REN RAD51 EDN1
4 heart development GO:0007507 9.88 VEGFB TEK EDNRA EDN1
5 in utero embryonic development GO:0001701 9.86 TIE1 EDNRA EDN1 ANGPT1
6 leukocyte migration GO:0050900 9.85 TEK ANGPT2 ANGPT1
7 positive regulation of protein kinase B signaling GO:0051897 9.85 VEGFB TEK ANGPT1
8 positive regulation of protein phosphorylation GO:0001934 9.85 VEGFD VEGFB TEK PGF ANGPT1
9 positive regulation of cytosolic calcium ion concentration GO:0007204 9.84 EDNRA EDN1 AGTR1
10 negative regulation of angiogenesis GO:0016525 9.83 TIE1 TEK ANGPT2
11 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.82 TIE1 TEK ANGPT1
12 platelet degranulation GO:0002576 9.82 VEGFD VEGFB SERPINE1
13 positive regulation of endothelial cell proliferation GO:0001938 9.78 VEGFD VEGFB TEK PGF
14 regulation of blood pressure GO:0008217 9.77 REN EDNRA EDN1
15 positive regulation of endothelial cell migration GO:0010595 9.75 TEK EDN1 ANGPT1
16 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.74 VEGFD VEGFB PGF
17 positive chemotaxis GO:0050918 9.73 VEGFD VEGFB PGF ANGPT1
18 positive regulation of cell division GO:0051781 9.71 VEGFD VEGFB PGF
19 negative regulation of endothelial cell apoptotic process GO:2000352 9.7 TEK SERPINE1 ANGPT1
20 response to hypoxia GO:0001666 9.7 VEGFD VEGFB TEK PGF EDNRA EDN1
21 vascular endothelial growth factor signaling pathway GO:0038084 9.69 VEGFD VEGFB PGF
22 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway GO:0051482 9.68 EDN1 AGTR1
23 respiratory gaseous exchange GO:0007585 9.68 EDNRA EDN1
24 branching involved in blood vessel morphogenesis GO:0001569 9.68 EDNRA EDN1
25 blood vessel morphogenesis GO:0048514 9.67 EDN1 ANGPT2
26 neural crest cell development GO:0014032 9.67 EDNRA EDN1
27 induction of positive chemotaxis GO:0050930 9.67 VEGFD VEGFB PGF
28 regulation of vasoconstriction GO:0019229 9.66 EDN1 AGTR1
29 vasoconstriction GO:0042310 9.65 EDNRA EDN1
30 sprouting angiogenesis GO:0002040 9.65 VEGFD VEGFB TEK PGF ANGPT1
31 negative regulation of blood coagulation GO:0030195 9.63 SERPINE1 EDN1
32 artery smooth muscle contraction GO:0014824 9.63 EDNRA EDN1
33 regulation of endothelial cell proliferation GO:0001936 9.61 TIE1 ANGPT1
34 regulation of glucose transmembrane transport GO:0010827 9.61 EDNRA EDN1
35 endothelin receptor signaling pathway GO:0086100 9.6 EDNRA EDN1
36 positive regulation of mast cell chemotaxis GO:0060754 9.58 VEGFD VEGFB PGF
37 renin-angiotensin regulation of aldosterone production GO:0002018 9.55 REN AGTR1
38 glomerulus vasculature development GO:0072012 9.54 TEK ANGPT2 ANGPT1
39 Tie signaling pathway GO:0048014 9.5 TEK ANGPT2 ANGPT1
40 positive regulation of angiogenesis GO:0045766 9.5 VEGFD VEGFB TIE1 TEK SERPINE1 PGF
41 angiogenesis GO:0001525 9.23 VEGFD VEGFB TIE1 TEK SERPINE1 PGF

Molecular functions related to Malignant Renovascular Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.55 SERPINE1 REN EDN1 ANGPT2 ANGPT1
2 growth factor activity GO:0008083 9.43 VEGFD VEGFB PGF
3 chemoattractant activity GO:0042056 9.13 VEGFD VEGFB PGF
4 vascular endothelial growth factor receptor binding GO:0005172 8.8 VEGFD VEGFB PGF

Sources for Malignant Renovascular Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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