MCID: MLG003
MIFTS: 23

Malignant Renovascular Hypertension

Categories: Cardiovascular diseases, Nephrological diseases

Aliases & Classifications for Malignant Renovascular Hypertension

MalaCards integrated aliases for Malignant Renovascular Hypertension:

Name: Malignant Renovascular Hypertension 12 15
Secondary Malignant Renovascular Hypertension 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13730
UMLS 73 C0264643

Summaries for Malignant Renovascular Hypertension

MalaCards based summary : Malignant Renovascular Hypertension, also known as secondary malignant renovascular hypertension, is related to renovascular hypertension and perinephritis. An important gene associated with Malignant Renovascular Hypertension is REN (Renin), and among its related pathways/superpathways are IL-1 Family Signaling Pathways and HIF-1 signaling pathway. Related phenotype is renal/urinary system.

Related Diseases for Malignant Renovascular Hypertension

Diseases in the Renovascular Hypertension family:

Benign Renovascular Hypertension Malignant Renovascular Hypertension

Diseases related to Malignant Renovascular Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 43)
# Related Disease Score Top Affiliating Genes
1 renovascular hypertension 30.4 EDN1 REN
2 perinephritis 10.1 EDN1 REN
3 renal tuberculosis 10.1 EDN1 REN
4 malignant hypertension 10.0 EDN1 REN
5 renal hypertension 10.0 EDN1 REN
6 hepatorenal syndrome 10.0 EDN1 REN
7 apnea, obstructive sleep 10.0 EDN1 REN
8 idiopathic hypercalciuria 10.0 EDN1 REN
9 obstructive jaundice 10.0 EDN1 REN
10 pulmonary edema 10.0 EDN1 REN
11 sleep apnea 10.0 EDN1 REN
12 urinary system disease 9.9 EDN1 REN
13 congestive heart failure 9.9 EDN1 REN
14 autosomal dominant polycystic kidney disease 9.8 EDN1 REN
15 angina pectoris 9.8 EDN1 SERPINE1
16 aortic aneurysm, familial abdominal, 1 9.8
17 aortic aneurysm 9.8
18 aneurysm 9.8
19 chronic kidney failure 9.8 EDN1 REN
20 idiopathic interstitial pneumonia 9.7 EDN1 SERPINE1
21 liver cirrhosis 9.7 EDN1 REN
22 hellp syndrome 9.7 EDN1 SERPINE1
23 ureteral disease 9.7 REN SERPINE1
24 tetralogy of fallot 9.7 EDN1 REN
25 aging 9.6 EDN1 SERPINE1
26 arteriosclerosis 9.6 EDN1 SERPINE1
27 renal fibrosis 9.6 REN SERPINE1
28 glucose metabolism disease 9.6 REN SERPINE1
29 acquired metabolic disease 9.6 REN SERPINE1
30 acute myocardial infarction 9.6 EDN1 SERPINE1
31 cerebrovascular disease 9.5 REN SERPINE1
32 stroke, ischemic 9.2 REN SERPINE1
33 coronary artery anomaly 9.2 EDN1 SERPINE1
34 kidney disease 9.2 EDN1 REN
35 malignant secondary hypertension 9.1 EDN1 REN SERPINE1
36 hepatic vascular disease 9.1 EDN1 REN SERPINE1
37 arteries, anomalies of 9.1 EDN1 REN SERPINE1
38 hypertension, essential 9.1 EDN1 REN SERPINE1
39 vascular disease 9.1 EDN1 REN SERPINE1
40 pre-eclampsia 9.1 EDN1 REN SERPINE1
41 pulmonary hypertension 9.1 EDN1 REN SERPINE1
42 myocardial infarction 9.0 EDN1 REN SERPINE1
43 diabetes mellitus 9.0 EDN1 REN SERPINE1

Comorbidity relations with Malignant Renovascular Hypertension via Phenotypic Disease Network (PDN): (show all 13)


Acute Cystitis Acute Kidney Failure
Chronic Kidney Failure Deficiency Anemia
Heart Disease Hypertension, Essential
Hypertensive Encephalopathy Intermediate Coronary Syndrome
Ischemic Heart Disease Malignant Essential Hypertension
Peripheral Vascular Disease Renal Artery Atheroma
Renal Artery Disease

Graphical network of the top 20 diseases related to Malignant Renovascular Hypertension:



Diseases related to Malignant Renovascular Hypertension

Symptoms & Phenotypes for Malignant Renovascular Hypertension

MGI Mouse Phenotypes related to Malignant Renovascular Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.8 EDN1 REN SERPINE1

Drugs & Therapeutics for Malignant Renovascular Hypertension

Search Clinical Trials , NIH Clinical Center for Malignant Renovascular Hypertension

Genetic Tests for Malignant Renovascular Hypertension

Anatomical Context for Malignant Renovascular Hypertension

Publications for Malignant Renovascular Hypertension

Articles related to Malignant Renovascular Hypertension:

# Title Authors Year
1
When the chimney is blocked: malignant renovascular hypertension after endovascular repair of abdominal aortic aneurysm. ( 23531087 )
2013
2
Predominant right ventricular infarction in malignant renovascular hypertension in rats. ( 3598333 )
1987
3
Control of malignant renovascular hypertension by percutaneous transluminal angioplasty and therapeutic renal embolization. ( 6767370 )
1980
4
Renin-angiotensin system in an infant with malignant renovascular hypertension. ( 939701 )
1976
5
Changes of plasma renin, angiotensin II and renin substrate during reversal of malignant renovascular hypertension. ( 1206969 )
1975
6
Malignant renovascular hypertension in a newborn. ( 5956765 )
1966

Variations for Malignant Renovascular Hypertension

Expression for Malignant Renovascular Hypertension

Search GEO for disease gene expression data for Malignant Renovascular Hypertension.

Pathways for Malignant Renovascular Hypertension

GO Terms for Malignant Renovascular Hypertension

Cellular components related to Malignant Renovascular Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 EDN1 REN SERPINE1

Biological processes related to Malignant Renovascular Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.37 EDN1 REN
2 response to lipopolysaccharide GO:0032496 9.32 EDN1 REN
3 cellular response to calcium ion GO:0071277 9.26 EDN1 SERPINE1
4 regulation of blood pressure GO:0008217 9.16 EDN1 REN
5 cellular response to drug GO:0035690 8.96 EDN1 REN
6 negative regulation of blood coagulation GO:0030195 8.62 EDN1 SERPINE1

Molecular functions related to Malignant Renovascular Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 8.8 EDN1 REN SERPINE1

Sources for Malignant Renovascular Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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