MCID: MLG080
MIFTS: 29

Malignant Secondary Hypertension

Categories: Blood diseases, Cancer diseases, Cardiovascular diseases, Genetic diseases, Nephrological diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Malignant Secondary Hypertension

MalaCards integrated aliases for Malignant Secondary Hypertension:

Name: Malignant Secondary Hypertension 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:13731
ICD9CM 34 405.0
SNOMED-CT 67 89242004
UMLS 70 C0155617

Summaries for Malignant Secondary Hypertension

MalaCards based summary : Malignant Secondary Hypertension is related to kidney papillary necrosis and trochlear nerve disease. An important gene associated with Malignant Secondary Hypertension is REN (Renin), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Malignant Secondary Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension
Hypertension Due to Gain-of-Function Mutations in the Mineralocorticoid Receptor

Diseases related to Malignant Secondary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 kidney papillary necrosis 10.3 REN EDN1
2 trochlear nerve disease 10.3 TRIM21 SERPINE1
3 femoral cancer 10.3 EDNRA EDN1
4 renovascular hypertension 10.3 REN EDN1 AGTR1
5 generalized atherosclerosis 10.3 SERPINE1 REN
6 acquired color blindness 10.3 EDNRA EDN1
7 perinephritis 10.3 REN EDNRA EDN1
8 hypertensive retinopathy 10.3 REN AGTR1
9 tricuspid valve insufficiency 10.3 REN EDNRA EDN1
10 pulmonary valve insufficiency 10.3 REN EDN1
11 transient refractive change 10.3 EDNRA EDN1
12 meningococcal infection 10.3 AGTR1 AGT
13 ureteral disease 10.3 SERPINE1 REN AGTR1
14 plantar fascial fibromatosis 10.3 AGTR1 AGT
15 coronary artery vasospasm 10.2 REN KNG1 EDN1
16 hepatic vascular disease 10.2 SERPINE1 REN EDN1
17 mandibulofacial dysostosis with alopecia 10.2 EDNRA EDN1
18 posterior urethral valves 10.2 AGTR1 AGT
19 myocardial stunning 10.2 KNG1 EDN1 AGTR1
20 diffuse scleroderma 10.2 TRIM21 KNG1 EDN1
21 limited scleroderma 10.2 TRIM21 EDNRA EDN1
22 intracranial berry aneurysm 10.2 REN EDNRA EDN1
23 potter's syndrome 10.2 REN AGT
24 portal hypertension 10.2 EDNRA EDN1 AGTR1
25 orthostatic intolerance 10.2 REN EDN1 AGTR1
26 fibromuscular dysplasia 10.2 REN AGTR1 AGT
27 anhidrosis, isolated, with normal sweat glands 10.2 EDNRA EDN1
28 renal artery disease 10.2 REN AGTR1 AGT
29 familial hypertension 10.2 REN AGTR1 AGT
30 impotence 10.2 KNG1 EDNRA EDN1
31 anuria 10.2 REN AGTR1 AGT
32 renal tubular dysgenesis 10.2 REN AGTR1 AGT
33 diastolic heart failure 10.2 REN AGTR1 AGT
34 renal dysplasia 10.2 REN AGTR1 AGT
35 hypertensive heart disease 10.2 REN AGTR1 AGT
36 interstitial nephritis 10.2 REN AGTR1 AGT
37 mitral valve disease 10.2 REN AGTR1 AGT
38 cholesterol embolism 10.2 REN F7
39 dic in newborn 10.2 SERPINE1 F7
40 aortic aneurysm, familial abdominal, 1 10.2 SERPINE1 REN AGTR1
41 vesicoureteral reflux 1 10.2 REN AGTR1 AGT
42 nonarteritic anterior ischemic optic neuropathy 10.2 EDN1 AGTR1 AGT
43 raynaud disease 10.2 TRIM21 EDNRA EDN1 AGTR1
44 nephrogenic systemic fibrosis 10.1 EDNRA EDN1
45 iga glomerulonephritis 10.1 REN AGTR1 AGT
46 patent foramen ovale 10.1 SERPINE1 REN EDNRA EDN1
47 retinal vein occlusion 10.1 SERPINE1 EDN1 ANGPT2
48 arteries, anomalies of 10.1 SERPINE1 REN EDN1 AGTR1
49 lipodermatosclerosis 10.1 ANGPT2 ANGPT1
50 migraine with or without aura 1 10.1 REN KNG1 EDNRA EDN1

Graphical network of the top 20 diseases related to Malignant Secondary Hypertension:



Diseases related to Malignant Secondary Hypertension

Symptoms & Phenotypes for Malignant Secondary Hypertension

MGI Mouse Phenotypes related to Malignant Secondary Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 AGT AGTR1 ANGPT1 ANGPT2 EDN1 EDNRA
2 homeostasis/metabolism MP:0005376 10.25 AGT AGTR1 ANGPT1 ANGPT2 EDN1 EDNRA
3 growth/size/body region MP:0005378 10.24 AGT AGTR1 ANGPT1 EDN1 EDNRA F7
4 mortality/aging MP:0010768 10.06 AGT AGTR1 ANGPT1 ANGPT2 EDN1 EDNRA
5 immune system MP:0005387 10.03 AGT AGTR1 ANGPT1 ANGPT2 EDNRA NCF2
6 adipose tissue MP:0005375 9.98 AGT AGTR1 F7 PGF SERPINE1 VEGFB
7 muscle MP:0005369 9.5 AGT ANGPT1 EDN1 EDNRA REN TEK
8 renal/urinary system MP:0005367 9.32 AGT AGTR1 ANGPT1 EDN1 EDNRA NCF2

Drugs & Therapeutics for Malignant Secondary Hypertension

Search Clinical Trials , NIH Clinical Center for Malignant Secondary Hypertension

Genetic Tests for Malignant Secondary Hypertension

Anatomical Context for Malignant Secondary Hypertension

Publications for Malignant Secondary Hypertension

Articles related to Malignant Secondary Hypertension:

# Title Authors PMID Year
1
Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension. 61
10930193 2000
2
Autoantibodies against cardiac G-protein-coupled receptors define different populations with cardiomyopathies but not with hypertension. 61
8020188 1994

Variations for Malignant Secondary Hypertension

Expression for Malignant Secondary Hypertension

Search GEO for disease gene expression data for Malignant Secondary Hypertension.

Pathways for Malignant Secondary Hypertension

Pathways related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 VEGFD VEGFB TEK SERPINE1 PGF NCF2
2
Show member pathways
13.71 VEGFD VEGFB TIE1 TEK RAD51 PGF
3
Show member pathways
13.46 VEGFD VEGFB TIE1 TEK PGF ANGPT2
4
Show member pathways
13.31 VEGFD VEGFB TIE1 TEK PGF ANGPT2
5
Show member pathways
13.22 VEGFD VEGFB TEK SERPINE1 KNG1 F7
6
Show member pathways
13.18 VEGFD VEGFB TIE1 TEK PGF NCF2
7
Show member pathways
12.96 VEGFD VEGFB REN PGF AGTR1 AGT
8
Show member pathways
12.9 VEGFD VEGFB TEK PGF ANGPT2 ANGPT1
9 12.67 VEGFD VEGFB TEK PGF ANGPT2 ANGPT1
10
Show member pathways
12.6 VEGFD VEGFB TEK PGF ANGPT2 ANGPT1
11
Show member pathways
12.43 KNG1 EDNRA AGTR1 AGT
12
Show member pathways
12.41 TIE1 TEK RAD51 ANGPT2 ANGPT1 AGTR1
13
Show member pathways
12.38 EDNRA EDN1 AGTR1 AGT
14
Show member pathways
12.32 VEGFD VEGFB TIE1 TEK PGF NCF2
15 12.29 VEGFD VEGFB EDNRA AGTR1
16 12.05 VEGFB TIE1 TEK ANGPT2
17 12 VEGFD VEGFB RAD51 PGF KNG1 EDNRA
18 11.76 TEK SERPINE1 EDN1 ANGPT2 ANGPT1
19 11.75 VEGFB TEK REN ANGPT2
20
Show member pathways
11.66 REN KNG1 AGTR1 AGT
21 11.5 VEGFD VEGFB EDN1
22 11.43 VEGFD VEGFB SERPINE1 EDN1 AGTR1 AGT
23 11.39 REN EDNRA EDN1 AGTR1 AGT
24 11.24 SERPINE1 EDN1 ANGPT2 ANGPT1
25 11.13 SERPINE1 ANGPT2 AGTR1
26
Show member pathways
10.81 VEGFD VEGFB PGF
27 10.76 VEGFD VEGFB TIE1 TEK PGF NCF2

GO Terms for Malignant Secondary Hypertension

Cellular components related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.73 SERPINE1 KNG1 F7 ANGPT2 ANGPT1 AGT
2 extracellular space GO:0005615 9.7 VEGFD VEGFB SERPINE1 REN PGF KNG1
3 platelet alpha granule lumen GO:0031093 9.46 VEGFD VEGFB SERPINE1 KNG1
4 extracellular region GO:0005576 9.4 VEGFD VEGFB TEK SERPINE1 REN PGF

Biological processes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 10.18 VEGFD TIE1 TEK PGF ANGPT2 ANGPT1
2 response to drug GO:0042493 9.99 VEGFB REN RAD51 EDN1
3 heart development GO:0007507 9.98 VEGFB TEK EDNRA EDN1
4 positive regulation of protein phosphorylation GO:0001934 9.98 VEGFD VEGFB TEK PGF ANGPT1
5 cell-cell signaling GO:0007267 9.97 TEK PGF EDN1 AGT
6 in utero embryonic development GO:0001701 9.96 TIE1 EDNRA EDN1 ANGPT1
7 positive regulation of protein kinase B signaling GO:0051897 9.95 VEGFB TEK F7 ANGPT1
8 negative regulation of angiogenesis GO:0016525 9.92 TIE1 TEK ANGPT2 AGT
9 platelet degranulation GO:0002576 9.91 VEGFD VEGFB SERPINE1 KNG1
10 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.89 TIE1 TEK ANGPT1
11 positive regulation of cytosolic calcium ion concentration GO:0007204 9.89 KNG1 EDNRA EDN1 AGTR1 AGT
12 positive regulation of endothelial cell proliferation GO:0001938 9.87 VEGFD VEGFB TEK PGF
13 positive regulation of inflammatory response GO:0050729 9.86 SERPINE1 AGTR1 AGT
14 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.86 VEGFB ANGPT1 AGT
15 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.86 TEK ANGPT1 AGT
16 regulation of blood pressure GO:0008217 9.85 REN EDNRA EDN1 AGT
17 positive regulation of endothelial cell migration GO:0010595 9.84 TEK EDN1 ANGPT1 AGT
18 positive regulation of cell division GO:0051781 9.82 VEGFD VEGFB PGF
19 vascular endothelial growth factor receptor signaling pathway GO:0048010 9.81 VEGFD VEGFB PGF NCF2
20 negative regulation of endothelial cell apoptotic process GO:2000352 9.8 TEK SERPINE1 ANGPT1
21 regulation of vasoconstriction GO:0019229 9.77 EDN1 AGTR1 AGT
22 vasoconstriction GO:0042310 9.77 EDNRA EDN1 AGT
23 positive chemotaxis GO:0050918 9.76 VEGFD VEGFB PGF ANGPT1
24 vascular endothelial growth factor signaling pathway GO:0038084 9.75 VEGFD VEGFB PGF
25 induction of positive chemotaxis GO:0050930 9.73 VEGFD VEGFB PGF
26 positive regulation of macrophage derived foam cell differentiation GO:0010744 9.71 AGTR1 AGT
27 low-density lipoprotein particle remodeling GO:0034374 9.7 AGTR1 AGT
28 superoxide anion generation GO:0042554 9.7 NCF2 EDN1
29 positive regulation of cellular protein metabolic process GO:0032270 9.7 AGTR1 AGT
30 positive regulation of blood coagulation GO:0030194 9.7 SERPINE1 F7
31 negative regulation of blood coagulation GO:0030195 9.7 SERPINE1 KNG1 EDN1
32 positive regulation of angiogenesis GO:0045766 9.7 VEGFD VEGFB TIE1 TEK SERPINE1 PGF
33 positive regulation of renal sodium excretion GO:0035815 9.69 EDN1 AGT
34 positive regulation of cholesterol esterification GO:0010873 9.68 AGTR1 AGT
35 regulation of endothelial cell proliferation GO:0001936 9.67 TIE1 ANGPT1
36 regulation of glucose transmembrane transport GO:0010827 9.67 EDNRA EDN1
37 endothelin receptor signaling pathway GO:0086100 9.66 EDNRA EDN1
38 positive regulation of NAD(P)H oxidase activity GO:0033864 9.65 AGTR1 AGT
39 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.65 AGTR1 AGT
40 artery smooth muscle contraction GO:0014824 9.65 EDNRA EDN1 AGT
41 sprouting angiogenesis GO:0002040 9.65 VEGFD VEGFB TEK PGF ANGPT1
42 regulation of extracellular matrix assembly GO:1901201 9.64 TIE1 AGT
43 regulation of renal sodium excretion GO:0035813 9.63 AGTR1 AGT
44 regulation of blood vessel diameter by renin-angiotensin GO:0002034 9.62 AGTR1 AGT
45 regulation of blood volume by renin-angiotensin GO:0002016 9.61 REN AGT
46 positive regulation of mast cell chemotaxis GO:0060754 9.61 VEGFD VEGFB PGF
47 glomerulus vasculature development GO:0072012 9.58 TEK ANGPT2 ANGPT1
48 angiogenesis GO:0001525 9.56 VEGFD VEGFB TIE1 TEK SERPINE1 PGF
49 Tie signaling pathway GO:0048014 9.54 TEK ANGPT2 ANGPT1
50 renin-angiotensin regulation of aldosterone production GO:0002018 9.5 REN AGTR1 AGT

Molecular functions related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.28 VEGFD VEGFB TRIM21 TIE1 TEK SERPINE1
2 growth factor activity GO:0008083 9.56 VEGFD VEGFB PGF AGT
3 chemoattractant activity GO:0042056 9.33 VEGFD VEGFB PGF
4 signaling receptor binding GO:0005102 9.17 SERPINE1 REN KNG1 F7 EDN1 ANGPT2
5 vascular endothelial growth factor receptor binding GO:0005172 9.13 VEGFD VEGFB PGF

Sources for Malignant Secondary Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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