MCID: MLG080
MIFTS: 26

Malignant Secondary Hypertension

Categories: Blood diseases, Cardiovascular diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Malignant Secondary Hypertension

MalaCards integrated aliases for Malignant Secondary Hypertension:

Name: Malignant Secondary Hypertension 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13731
ICD9CM 35 405.0
SNOMED-CT 68 49863005 89242004
ICD10 33 I15
UMLS 73 C0155617

Summaries for Malignant Secondary Hypertension

MalaCards based summary : Malignant Secondary Hypertension is related to multicystic dysplastic kidney and hemoglobin lepore-beta-thalassemia syndrome. An important gene associated with Malignant Secondary Hypertension is HBD (Hemoglobin Subunit Delta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and HIF-1-alpha transcription factor network. Affiliated tissues include kidney and heart, and related phenotypes are Decreased melanin production and renal/urinary system

Related Diseases for Malignant Secondary Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension

Diseases related to Malignant Secondary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 multicystic dysplastic kidney 10.1 AGTR2 REN
2 hemoglobin lepore-beta-thalassemia syndrome 10.1 HBB HBD
3 thalassemia 10.1 HBB HBD
4 hemoglobin d disease 10.1 HBB HBD
5 hemoglobin c disease 10.1 HBB HBD
6 renovascular hypertension 10.1 EDN1 REN
7 hemoglobin e disease 10.1 HBB HBD
8 eclampsia 10.1 EDN1 REN
9 osgood-schlatter's disease 10.1 HBB HBD
10 fetal hemoglobin quantitative trait locus 1 10.1 HBB HBD
11 kluver-bucy syndrome 10.1 HBB HBD
12 blind loop syndrome 10.1 HBB HBD
13 pleuropneumonia 10.1 HBB HBD
14 perinephritis 10.1 EDN1 REN
15 pseudohyperkalemia, familial, 2, due to red cell leak 10.1 AGTR2 REN
16 blood protein disease 10.1 HBB HBD
17 malignant hypertension 10.1 EDN1 REN
18 obstructive nephropathy 10.1 AGTR2 REN
19 renal tuberculosis 10.1 EDN1 REN
20 alpha thalassemia-intellectual disability syndrome type 1 10.1 HBB HBD
21 hemoglobin h disease 10.1 HBB HBD
22 hepatorenal syndrome 10.1 EDN1 REN
23 sickle cell disease 10.1 HBB HBD
24 apnea, obstructive sleep 10.1 EDN1 REN
25 idiopathic hypercalciuria 10.1 EDN1 REN
26 hemoglobinopathy 10.1 HBB HBD
27 myocardial stunning 10.1 AGTR2 EDN1
28 vesicoureteral reflux 1 10.1 AGTR2 REN
29 obstructive jaundice 10.1 EDN1 REN
30 oligohydramnios 10.1 EDN1 REN
31 congenital hemolytic anemia 10.0 HBB HBD
32 acute chest syndrome 10.0 EDN1 HBB
33 pulmonary edema 10.0 EDN1 REN
34 sleep apnea 10.0 EDN1 REN
35 autosomal genetic disease 10.0 HBB HBD
36 urinary system disease 10.0 EDN1 REN
37 impotence 10.0 EDN1 KNG1
38 renal fibrosis 9.9 REN SERPINE1
39 lemierre's syndrome 9.9 KNG1 SERPINE1
40 glucose metabolism disease 9.9 REN SERPINE1
41 renal hypertension 9.9 EDN1 KNG1 REN
42 congestive heart failure 9.9 EDN1 KNG1 REN
43 idiopathic interstitial pneumonia 9.9 EDN1 SERPINE1
44 acquired metabolic disease 9.8 REN SERPINE1
45 stroke, ischemic 9.8 AGTR2 REN SERPINE1
46 malignant hypertensive renal disease 9.8 EDN1 REN SERPINE1
47 malignant renovascular hypertension 9.8 EDN1 REN SERPINE1
48 hepatic vascular disease 9.8 EDN1 REN SERPINE1
49 hellp syndrome 9.8 EDN1 SERPINE1
50 coronary artery anomaly 9.7 EDN1 KNG1 SERPINE1

Graphical network of the top 20 diseases related to Malignant Secondary Hypertension:



Diseases related to Malignant Secondary Hypertension

Symptoms & Phenotypes for Malignant Secondary Hypertension

GenomeRNAi Phenotypes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased melanin production GR00056-A 8.62 AGTR2 SERPINE1

MGI Mouse Phenotypes related to Malignant Secondary Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 AGTR2 EDN1 REN SERPINE1

Drugs & Therapeutics for Malignant Secondary Hypertension

Search Clinical Trials , NIH Clinical Center for Malignant Secondary Hypertension

Genetic Tests for Malignant Secondary Hypertension

Anatomical Context for Malignant Secondary Hypertension

MalaCards organs/tissues related to Malignant Secondary Hypertension:

41
Kidney, Heart

Publications for Malignant Secondary Hypertension

Variations for Malignant Secondary Hypertension

Expression for Malignant Secondary Hypertension

Search GEO for disease gene expression data for Malignant Secondary Hypertension.

Pathways for Malignant Secondary Hypertension

GO Terms for Malignant Secondary Hypertension

Cellular components related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.72 EDN1 HBB KNG1 REN SERPINE1
2 blood microparticle GO:0072562 9.43 HBB HBD KNG1
3 extracellular region GO:0005576 9.43 AGTR2 EDN1 HBB KNG1 REN SERPINE1
4 platelet alpha granule lumen GO:0031093 9.37 KNG1 SERPINE1
5 hemoglobin complex GO:0005833 9.16 HBB HBD
6 haptoglobin-hemoglobin complex GO:0031838 8.62 HBB HBD

Biological processes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.65 HBB HBD KNG1
2 cellular oxidant detoxification GO:0098869 9.54 HBB HBD
3 protein heterooligomerization GO:0051291 9.52 HBB HBD
4 cellular response to drug GO:0035690 9.51 EDN1 REN
5 hydrogen peroxide catabolic process GO:0042744 9.49 HBB HBD
6 vasodilation GO:0042311 9.46 AGTR2 KNG1
7 oxygen transport GO:0015671 9.43 HBB HBD
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 AGTR2 EDN1 HBB
9 positive regulation of renal sodium excretion GO:0035815 9.4 AGTR2 EDN1
10 renin-angiotensin regulation of aldosterone production GO:0002018 9.37 AGTR2 REN
11 regulation of blood vessel size GO:0050880 9.33 EDN1 HBB KNG1
12 nitric oxide transport GO:0030185 9.32 EDN1 HBB
13 negative regulation of blood coagulation GO:0030195 9.13 EDN1 KNG1 SERPINE1
14 regulation of blood pressure GO:0008217 8.92 AGTR2 EDN1 HBB REN

Molecular functions related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.4 HBB HBD
2 peroxidase activity GO:0004601 9.37 HBB HBD
3 oxygen carrier activity GO:0005344 9.32 HBB HBD
4 organic acid binding GO:0043177 9.26 HBB HBD
5 signaling receptor binding GO:0005102 9.26 EDN1 KNG1 REN SERPINE1
6 haptoglobin binding GO:0031720 9.16 HBB HBD
7 hemoglobin alpha binding GO:0031721 8.62 HBB HBD

Sources for Malignant Secondary Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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