MCID: MLG080
MIFTS: 24

Malignant Secondary Hypertension

Categories: Cardiovascular diseases, Genetic diseases, Blood diseases, Rare diseases

Aliases & Classifications for Malignant Secondary Hypertension

MalaCards integrated aliases for Malignant Secondary Hypertension:

Name: Malignant Secondary Hypertension 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13731
ICD9CM 35 405.0
ICD10 33 I15
UMLS 73 C0155617

Summaries for Malignant Secondary Hypertension

MalaCards based summary : Malignant Secondary Hypertension is related to multicystic dysplastic kidney and hemoglobin lepore-beta-thalassemia syndrome. An important gene associated with Malignant Secondary Hypertension is HBD (Hemoglobin Subunit Delta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and HIF-1-alpha transcription factor network. Related phenotypes are Decreased melanin production and renal/urinary system

Related Diseases for Malignant Secondary Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Malignant Hypertension Benign Essential Hypertension
Benign Secondary Hypertension Malignant Secondary Hypertension

Diseases related to Malignant Secondary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 multicystic dysplastic kidney 10.4 AGTR2 REN
2 hemoglobin lepore-beta-thalassemia syndrome 10.4 HBB HBD
3 hemoglobin d disease 10.4 HBB HBD
4 hemoglobin e disease 10.4 HBB HBD
5 hemoglobin c disease 10.4 HBB HBD
6 osgood-schlatter's disease 10.4 HBB HBD
7 fetal hemoglobin quantitative trait locus 1 10.4 HBB HBD
8 kluver-bucy syndrome 10.4 HBB HBD
9 perinephritis 10.3 EDN1 REN
10 pleuropneumonia 10.3 HBB HBD
11 pseudohyperkalemia, familial, 2, due to red cell leak 10.3 AGTR2 REN
12 renal tuberculosis 10.3 EDN1 REN
13 malignant hypertension 10.3 EDN1 REN
14 hepatorenal syndrome 10.3 EDN1 REN
15 apnea, obstructive sleep 10.3 EDN1 REN
16 hemoglobin h disease 10.3 HBB HBD
17 renovascular hypertension 10.3 EDN1 REN
18 hemoglobinopathy 10.2 HBB HBD
19 sickle cell disease 10.2 HBB HBD
20 idiopathic hypercalciuria 10.2 EDN1 REN
21 vesicoureteral reflux 1 10.2 AGTR2 REN
22 obstructive jaundice 10.2 EDN1 REN
23 congenital hemolytic anemia 10.2 HBB HBD
24 pulmonary edema 10.2 EDN1 REN
25 acute chest syndrome 10.2 EDN1 HBB
26 autosomal genetic disease 10.1 HBB HBD
27 coronary artery vasospasm 10.1 EDN1 KNG1
28 sleep apnea 10.1 EDN1 REN
29 diffuse scleroderma 10.1 EDN1 KNG1
30 urinary system disease 9.9 EDN1 REN
31 ureteral disease 9.9 REN SERPINE1
32 impotence 9.9 EDN1 KNG1
33 angina pectoris 9.8 EDN1 SERPINE1
34 lemierre's syndrome 9.7 KNG1 SERPINE1
35 renal fibrosis 9.7 REN SERPINE1
36 renal hypertension 9.6 EDN1 KNG1 REN
37 congestive heart failure 9.6 EDN1 KNG1 REN
38 glucose metabolism disease 9.6 REN SERPINE1
39 idiopathic interstitial pneumonia 9.6 EDN1 SERPINE1
40 thalassemia 9.5 HBB HBD
41 acquired metabolic disease 9.5 REN SERPINE1
42 stroke, ischemic 9.4 AGTR2 REN SERPINE1
43 malignant renovascular hypertension 9.4 EDN1 REN SERPINE1
44 hepatic vascular disease 9.4 EDN1 REN SERPINE1
45 pulmonary hypertension 9.3 EDN1 REN SERPINE1
46 hellp syndrome 9.2 EDN1 SERPINE1
47 heart disease 9.1 AGTR2 EDN1 KNG1 REN
48 diabetes mellitus 8.7 EDN1 HBB REN SERPINE1
49 arteries, anomalies of 8.7 EDN1 KNG1 REN SERPINE1
50 malignant essential hypertension 8.7 AGTR2 HBB HBD KNG1 REN

Graphical network of the top 20 diseases related to Malignant Secondary Hypertension:



Diseases related to Malignant Secondary Hypertension

Symptoms & Phenotypes for Malignant Secondary Hypertension

GenomeRNAi Phenotypes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased melanin production GR00056-A 8.62 AGTR2 SERPINE1

MGI Mouse Phenotypes related to Malignant Secondary Hypertension:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 8.92 AGTR2 EDN1 REN SERPINE1

Drugs & Therapeutics for Malignant Secondary Hypertension

Search Clinical Trials , NIH Clinical Center for Malignant Secondary Hypertension

Genetic Tests for Malignant Secondary Hypertension

Anatomical Context for Malignant Secondary Hypertension

Publications for Malignant Secondary Hypertension

Variations for Malignant Secondary Hypertension

Expression for Malignant Secondary Hypertension

Search GEO for disease gene expression data for Malignant Secondary Hypertension.

Pathways for Malignant Secondary Hypertension

GO Terms for Malignant Secondary Hypertension

Cellular components related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 EDN1 HBB KNG1 REN SERPINE1
2 blood microparticle GO:0072562 9.33 HBB HBD KNG1
3 platelet alpha granule lumen GO:0031093 9.32 KNG1 SERPINE1
4 extracellular region GO:0005576 9.1 AGTR2 EDN1 HBB KNG1 REN SERPINE1
5 hemoglobin complex GO:0005833 8.96 HBB HBD

Biological processes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.65 HBB HBD KNG1
2 cellular response to calcium ion GO:0071277 9.51 EDN1 SERPINE1
3 cellular response to drug GO:0035690 9.49 EDN1 REN
4 vasodilation GO:0042311 9.46 AGTR2 KNG1
5 oxygen transport GO:0015671 9.43 HBB HBD
6 positive regulation of nitric oxide biosynthetic process GO:0045429 9.43 AGTR2 EDN1 HBB
7 positive regulation of renal sodium excretion GO:0035815 9.4 AGTR2 EDN1
8 renin-angiotensin regulation of aldosterone production GO:0002018 9.37 AGTR2 REN
9 regulation of blood vessel size GO:0050880 9.33 EDN1 HBB KNG1
10 nitric oxide transport GO:0030185 9.32 EDN1 HBB
11 negative regulation of blood coagulation GO:0030195 9.13 EDN1 KNG1 SERPINE1
12 regulation of blood pressure GO:0008217 8.92 AGTR2 EDN1 HBB REN

Molecular functions related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxygen binding GO:0019825 9.16 HBB HBD
2 oxygen carrier activity GO:0005344 8.96 HBB HBD
3 signaling receptor binding GO:0005102 8.92 EDN1 KNG1 REN SERPINE1

Sources for Malignant Secondary Hypertension

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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