Malignant Secondary Hypertension disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Malignant Secondary Hypertension

MalaCards integrated aliases for Malignant Secondary Hypertension:

Name: Malignant Secondary Hypertension ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the circulatory system

Hypertensive diseases

Secondary hypertension

External Ids:

Disease Ontology ¹² DOID:13731

ICD9CM ³⁵ 405.0

SNOMED-CT ⁶⁸ 49863005 89242004

ICD10 ³³ I15

UMLS ⁷³ C0155617

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Summaries for Malignant Secondary Hypertension

MalaCards based summary : Malignant Secondary Hypertension is related to multicystic dysplastic kidney and hemoglobin lepore-beta-thalassemia syndrome. An important gene associated with Malignant Secondary Hypertension is HBD (Hemoglobin Subunit Delta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and HIF-1-alpha transcription factor network. Affiliated tissues include kidney and heart, and related phenotypes are Decreased melanin production and renal/urinary system

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Related Diseases for Malignant Secondary Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential	Hypertension, Essential 1
Hypertension, Essential 2	Hypertension, Essential 3
Hypertension, Essential 4	Hypertension, Essential 5
Hypertension, Essential 6	Hypertension, Essential 7
Hypertension, Essential 8	Malignant Essential Hypertension
Malignant Hypertension	Benign Essential Hypertension
Benign Secondary Hypertension	Malignant Secondary Hypertension

Diseases related to Malignant Secondary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)

#	Related Disease	Score	Top Affiliating Genes
1	multicystic dysplastic kidney	10.1	AGTR2 REN
2	hemoglobin lepore-beta-thalassemia syndrome	10.1	HBB HBD
3	thalassemia	10.1	HBB HBD
4	hemoglobin d disease	10.1	HBB HBD
5	hemoglobin c disease	10.1	HBB HBD
6	renovascular hypertension	10.1	EDN1 REN
7	hemoglobin e disease	10.1	HBB HBD
8	eclampsia	10.1	EDN1 REN
9	osgood-schlatter's disease	10.1	HBB HBD
10	fetal hemoglobin quantitative trait locus 1	10.1	HBB HBD
11	kluver-bucy syndrome	10.1	HBB HBD
12	blind loop syndrome	10.1	HBB HBD
13	pleuropneumonia	10.1	HBB HBD
14	perinephritis	10.1	EDN1 REN
15	pseudohyperkalemia, familial, 2, due to red cell leak	10.1	AGTR2 REN
16	blood protein disease	10.1	HBB HBD
17	malignant hypertension	10.1	EDN1 REN
18	obstructive nephropathy	10.1	AGTR2 REN
19	renal tuberculosis	10.1	EDN1 REN
20	alpha thalassemia-intellectual disability syndrome type 1	10.1	HBB HBD
21	hemoglobin h disease	10.1	HBB HBD
22	hepatorenal syndrome	10.1	EDN1 REN
23	sickle cell disease	10.1	HBB HBD
24	apnea, obstructive sleep	10.1	EDN1 REN
25	idiopathic hypercalciuria	10.1	EDN1 REN
26	hemoglobinopathy	10.1	HBB HBD
27	myocardial stunning	10.1	AGTR2 EDN1
28	vesicoureteral reflux 1	10.1	AGTR2 REN
29	obstructive jaundice	10.1	EDN1 REN
30	oligohydramnios	10.1	EDN1 REN
31	congenital hemolytic anemia	10.0	HBB HBD
32	acute chest syndrome	10.0	EDN1 HBB
33	pulmonary edema	10.0	EDN1 REN
34	sleep apnea	10.0	EDN1 REN
35	autosomal genetic disease	10.0	HBB HBD
36	urinary system disease	10.0	EDN1 REN
37	impotence	10.0	EDN1 KNG1
38	renal fibrosis	9.9	REN SERPINE1
39	lemierre's syndrome	9.9	KNG1 SERPINE1
40	glucose metabolism disease	9.9	REN SERPINE1
41	renal hypertension	9.9	EDN1 KNG1 REN
42	congestive heart failure	9.9	EDN1 KNG1 REN
43	idiopathic interstitial pneumonia	9.9	EDN1 SERPINE1
44	acquired metabolic disease	9.8	REN SERPINE1
45	stroke, ischemic	9.8	AGTR2 REN SERPINE1
46	malignant hypertensive renal disease	9.8	EDN1 REN SERPINE1
47	malignant renovascular hypertension	9.8	EDN1 REN SERPINE1
48	hepatic vascular disease	9.8	EDN1 REN SERPINE1
49	hellp syndrome	9.8	EDN1 SERPINE1
50	coronary artery anomaly	9.7	EDN1 KNG1 SERPINE1

Graphical network of the top 20 diseases related to Malignant Secondary Hypertension:

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Symptoms & Phenotypes for Malignant Secondary Hypertension

GenomeRNAi Phenotypes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased melanin production	GR00056-A	8.62	AGTR2 SERPINE1

MGI Mouse Phenotypes related to Malignant Secondary Hypertension:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system	MP:0005367	8.92	AGTR2 EDN1 REN SERPINE1

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Drugs & Therapeutics for Malignant Secondary Hypertension

Search Clinical Trials , NIH Clinical Center for Malignant Secondary Hypertension

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Genetic Tests for Malignant Secondary Hypertension

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Anatomical Context for Malignant Secondary Hypertension

MalaCards organs/tissues related to Malignant Secondary Hypertension:

⁴¹

Kidney, Heart

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Publications for Malignant Secondary Hypertension

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Genes for Malignant Secondary Hypertension

Genes related to Malignant Secondary Hypertension (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HBD	Hemoglobin Subunit Delta	Protein Coding	15.14	DISEASES inferred ¹⁵
2	REN	Renin	Protein Coding	15.12	DISEASES inferred ¹⁵
3	AGTR2	Angiotensin II Receptor Type 2	Protein Coding	14.67	DISEASES inferred ¹⁵
4	HBB	Hemoglobin Subunit Beta	Protein Coding	14.13	DISEASES inferred ¹⁵
5	KNG1	Kininogen 1	Protein Coding	13.85	DISEASES inferred ¹⁵
6	SERPINE1	Serpin Family E Member 1	Protein Coding	13.52	DISEASES inferred ¹⁵
7	EDN1	Endothelin 1	Protein Coding	13.51	DISEASES inferred ¹⁵

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Variations for Malignant Secondary Hypertension

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Expression for Malignant Secondary Hypertension

Search GEO for disease gene expression data for Malignant Secondary Hypertension.

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Pathways for Malignant Secondary Hypertension

Pathways related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.64	HBB HBD KNG1 SERPINE1
2	HIF-1-alpha transcription factor network ¹	10.97	EDN1 SERPINE1
3	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶¹ Show member pathways ACE Inhibitor Pathway ¹ ACE Inhibitor Pathway, Pharmacodynamics ⁶¹ Renin-angiotensin system ³⁷	10.7	AGTR2 KNG1 REN
4	Photodynamic therapy-induced HIF-1 survival signaling ¹	10.52	EDN1 SERPINE1

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GO Terms for Malignant Secondary Hypertension

Cellular components related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.72	EDN1 HBB KNG1 REN SERPINE1
2	blood microparticle	GO:0072562	9.43	HBB HBD KNG1
3	extracellular region	GO:0005576	9.43	AGTR2 EDN1 HBB KNG1 REN SERPINE1
4	platelet alpha granule lumen	GO:0031093	9.37	KNG1 SERPINE1
5	hemoglobin complex	GO:0005833	9.16	HBB HBD
6	haptoglobin-hemoglobin complex	GO:0031838	8.62	HBB HBD

Biological processes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:0007596	9.65	HBB HBD KNG1
2	cellular oxidant detoxification	GO:0098869	9.54	HBB HBD
3	protein heterooligomerization	GO:0051291	9.52	HBB HBD
4	cellular response to drug	GO:0035690	9.51	EDN1 REN
5	hydrogen peroxide catabolic process	GO:0042744	9.49	HBB HBD
6	vasodilation	GO:0042311	9.46	AGTR2 KNG1
7	oxygen transport	GO:0015671	9.43	HBB HBD
8	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.43	AGTR2 EDN1 HBB
9	positive regulation of renal sodium excretion	GO:0035815	9.4	AGTR2 EDN1
10	renin-angiotensin regulation of aldosterone production	GO:0002018	9.37	AGTR2 REN
11	regulation of blood vessel size	GO:0050880	9.33	EDN1 HBB KNG1
12	nitric oxide transport	GO:0030185	9.32	EDN1 HBB
13	negative regulation of blood coagulation	GO:0030195	9.13	EDN1 KNG1 SERPINE1
14	regulation of blood pressure	GO:0008217	8.92	AGTR2 EDN1 HBB REN

Molecular functions related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxygen binding	GO:0019825	9.4	HBB HBD
2	peroxidase activity	GO:0004601	9.37	HBB HBD
3	oxygen carrier activity	GO:0005344	9.32	HBB HBD
4	organic acid binding	GO:0043177	9.26	HBB HBD
5	signaling receptor binding	GO:0005102	9.26	EDN1 KNG1 REN SERPINE1
6	haptoglobin binding	GO:0031720	9.16	HBB HBD
7	hemoglobin alpha binding	GO:0031721	8.62	HBB HBD

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Sources for Malignant Secondary Hypertension

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