Malignant Secondary Hypertension disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Malignant Secondary Hypertension

MalaCards integrated aliases for Malignant Secondary Hypertension:

Name: Malignant Secondary Hypertension ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the circulatory system

Hypertensive diseases

Secondary hypertension

External Ids:

Disease Ontology ¹² DOID:13731

ICD9CM ³⁵ 405.0

SNOMED-CT ⁶⁸ 194784007 49863005 89242004

ICD10 ³³ I15

UMLS ⁷³ C0155617

Sources

Summaries for Malignant Secondary Hypertension

MalaCards based summary : Malignant Secondary Hypertension is related to multicystic dysplastic kidney and hemoglobin lepore-beta-thalassemia syndrome. An important gene associated with Malignant Secondary Hypertension is HBD (Hemoglobin Subunit Delta), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and HIF-1-alpha transcription factor network. Related phenotypes are Decreased melanin production and renal/urinary system

Sources

Related Diseases for Malignant Secondary Hypertension

Diseases in the Familial Hypertension family:

Hypertension, Essential	Hypertension, Essential 1
Hypertension, Essential 2	Hypertension, Essential 3
Hypertension, Essential 4	Hypertension, Essential 5
Hypertension, Essential 6	Hypertension, Essential 7
Hypertension, Essential 8	Malignant Essential Hypertension
Malignant Hypertension	Benign Essential Hypertension
Benign Secondary Hypertension	Malignant Secondary Hypertension

Diseases related to Malignant Secondary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)

#	Related Disease	Score	Top Affiliating Genes
1	multicystic dysplastic kidney	10.4	AGTR2 REN
2	hemoglobin lepore-beta-thalassemia syndrome	10.4	HBB HBD
3	hemoglobin d disease	10.4	HBB HBD
4	hemoglobin e disease	10.4	HBB HBD
5	hemoglobin c disease	10.4	HBB HBD
6	osgood-schlatter's disease	10.4	HBB HBD
7	fetal hemoglobin quantitative trait locus 1	10.4	HBB HBD
8	kluver-bucy syndrome	10.4	HBB HBD
9	perinephritis	10.3	EDN1 REN
10	pleuropneumonia	10.3	HBB HBD
11	pseudohyperkalemia, familial, 2, due to red cell leak	10.3	AGTR2 REN
12	renal tuberculosis	10.3	EDN1 REN
13	malignant hypertension	10.3	EDN1 REN
14	hepatorenal syndrome	10.3	EDN1 REN
15	apnea, obstructive sleep	10.3	EDN1 REN
16	hemoglobin h disease	10.3	HBB HBD
17	renovascular hypertension	10.3	EDN1 REN
18	hemoglobinopathy	10.2	HBB HBD
19	sickle cell disease	10.2	HBB HBD
20	idiopathic hypercalciuria	10.2	EDN1 REN
21	vesicoureteral reflux 1	10.2	AGTR2 REN
22	obstructive jaundice	10.2	EDN1 REN
23	congenital hemolytic anemia	10.2	HBB HBD
24	pulmonary edema	10.2	EDN1 REN
25	acute chest syndrome	10.2	EDN1 HBB
26	autosomal genetic disease	10.1	HBB HBD
27	coronary artery vasospasm	10.1	EDN1 KNG1
28	sleep apnea	10.1	EDN1 REN
29	diffuse scleroderma	10.1	EDN1 KNG1
30	urinary system disease	9.9	EDN1 REN
31	ureteral disease	9.9	REN SERPINE1
32	impotence	9.9	EDN1 KNG1
33	angina pectoris	9.8	EDN1 SERPINE1
34	lemierre's syndrome	9.7	KNG1 SERPINE1
35	renal fibrosis	9.7	REN SERPINE1
36	renal hypertension	9.6	EDN1 KNG1 REN
37	congestive heart failure	9.6	EDN1 KNG1 REN
38	glucose metabolism disease	9.6	REN SERPINE1
39	idiopathic interstitial pneumonia	9.6	EDN1 SERPINE1
40	thalassemia	9.5	HBB HBD
41	acquired metabolic disease	9.5	REN SERPINE1
42	stroke, ischemic	9.4	AGTR2 REN SERPINE1
43	malignant renovascular hypertension	9.4	EDN1 REN SERPINE1
44	hepatic vascular disease	9.4	EDN1 REN SERPINE1
45	pulmonary hypertension	9.3	EDN1 REN SERPINE1
46	hellp syndrome	9.2	EDN1 SERPINE1
47	heart disease	9.1	AGTR2 EDN1 KNG1 REN
48	diabetes mellitus	8.7	EDN1 HBB REN SERPINE1
49	arteries, anomalies of	8.7	EDN1 KNG1 REN SERPINE1
50	malignant essential hypertension	8.7	AGTR2 HBB HBD KNG1 REN

Graphical network of the top 20 diseases related to Malignant Secondary Hypertension:

Sources

Symptoms & Phenotypes for Malignant Secondary Hypertension

GenomeRNAi Phenotypes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased melanin production	GR00056-A	8.62	AGTR2 SERPINE1

MGI Mouse Phenotypes related to Malignant Secondary Hypertension:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	renal/urinary system	MP:0005367	8.92	AGTR2 EDN1 REN SERPINE1

Sources

Drugs & Therapeutics for Malignant Secondary Hypertension

Search Clinical Trials , NIH Clinical Center for Malignant Secondary Hypertension

Sources

Genetic Tests for Malignant Secondary Hypertension

Sources

Anatomical Context for Malignant Secondary Hypertension

Sources

Publications for Malignant Secondary Hypertension

Sources

Genes for Malignant Secondary Hypertension

Genes related to Malignant Secondary Hypertension (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	HBD	Hemoglobin Subunit Delta	Protein Coding	15.17	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	REN	Renin	Protein Coding	15.16	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	AGTR2	Angiotensin II Receptor Type 2	Protein Coding	14.75	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	HBB	Hemoglobin Subunit Beta	Protein Coding	14.15	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	KNG1	Kininogen 1	Protein Coding	13.91	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	SERPINE1	Serpin Family E Member 1	Protein Coding	13.59	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	EDN1	Endothelin 1	Protein Coding	13.57	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

Sources

Variations for Malignant Secondary Hypertension

Sources

Expression for Malignant Secondary Hypertension

Search GEO for disease gene expression data for Malignant Secondary Hypertension.

Sources

Pathways for Malignant Secondary Hypertension

Pathways related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	12.64	HBB HBD KNG1 SERPINE1
2	HIF-1-alpha transcription factor network ¹	10.97	EDN1 SERPINE1
3	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics ⁶¹ Show member pathways ACE Inhibitor Pathway ¹ ACE Inhibitor Pathway, Pharmacodynamics ⁶¹ Renin-angiotensin system ³⁷	10.7	AGTR2 KNG1 REN
4	Photodynamic therapy-induced HIF-1 survival signaling ¹	10.52	EDN1 SERPINE1

Sources

GO Terms for Malignant Secondary Hypertension

Cellular components related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.65	EDN1 HBB KNG1 REN SERPINE1
2	blood microparticle	GO:0072562	9.33	HBB HBD KNG1
3	platelet alpha granule lumen	GO:0031093	9.32	KNG1 SERPINE1
4	extracellular region	GO:0005576	9.1	AGTR2 EDN1 HBB KNG1 REN SERPINE1
5	hemoglobin complex	GO:0005833	8.96	HBB HBD

Biological processes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:0007596	9.65	HBB HBD KNG1
2	cellular response to calcium ion	GO:0071277	9.51	EDN1 SERPINE1
3	cellular response to drug	GO:0035690	9.49	EDN1 REN
4	vasodilation	GO:0042311	9.46	AGTR2 KNG1
5	oxygen transport	GO:0015671	9.43	HBB HBD
6	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.43	AGTR2 EDN1 HBB
7	positive regulation of renal sodium excretion	GO:0035815	9.4	AGTR2 EDN1
8	renin-angiotensin regulation of aldosterone production	GO:0002018	9.37	AGTR2 REN
9	regulation of blood vessel size	GO:0050880	9.33	EDN1 HBB KNG1
10	nitric oxide transport	GO:0030185	9.32	EDN1 HBB
11	negative regulation of blood coagulation	GO:0030195	9.13	EDN1 KNG1 SERPINE1
12	regulation of blood pressure	GO:0008217	8.92	AGTR2 EDN1 HBB REN

Molecular functions related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oxygen binding	GO:0019825	9.16	HBB HBD
2	oxygen carrier activity	GO:0005344	8.96	HBB HBD
3	signaling receptor binding	GO:0005102	8.92	EDN1 KNG1 REN SERPINE1

Sources

Sources for Malignant Secondary Hypertension

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia