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MCID: MLG080
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Malignant Secondary Hypertension

Categories: Cancer diseases, Cardiovascular diseases, Genetic diseases, Nephrological diseases, Rare diseases, Reproductive diseases
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Aliases & Classifications for Malignant Secondary Hypertension

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MalaCards integrated aliases for Malignant Secondary Hypertension:

Name: Malignant Secondary Hypertension 11 14 71

Classifications:

MalaCards categories:
Global: Cancer diseases Genetic diseases Rare diseases
Anatomical: Cardiovascular diseases Nephrological diseases Reproductive diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 11 DOID:13731
ICD9CM 34 405.0
SNOMED-CT 68 89242004
UMLS 71 C0155617
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Summaries for Malignant Secondary Hypertension

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MalaCards based summary: Malignant Secondary Hypertension is related to renal artery atheroma and conjunctival vascular disease. An important gene associated with Malignant Secondary Hypertension is AGTR1 (Angiotensin II Receptor Type 1), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. Related phenotypes are homeostasis/metabolism and nervous system
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Related Diseases for Malignant Secondary Hypertension

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Diseases in the Malignant Hypertension family:

Hypertension, Essential Hypertension, Essential 1
Hypertension, Essential 2 Hypertension, Essential 3
Hypertension, Essential 4 Hypertension, Essential 5
Hypertension, Essential 6 Hypertension, Essential 7
Hypertension, Essential 8 Malignant Essential Hypertension
Benign Essential Hypertension Benign Secondary Hypertension
Malignant Secondary Hypertension Hypertension Due to Gain-of-Function Mutations in the Mineralocorticoid Receptor

Diseases related to Malignant Secondary Hypertension via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
# Related Disease Score Top Affiliating Genes
1 renal artery atheroma 10.3 REN AGTR1
2 conjunctival vascular disease 10.3 TRIM21 EDN1
3 femoral cancer 10.3 EDNRA EDN1
4 acute anterolateral myocardial infarction 10.3 REN AGTR1
5 hypoaldosteronism 10.3 REN CYP11B2
6 hypertensive encephalopathy 10.3 REN EDN1 AGTR1
7 perinephritis 10.3 REN EDNRA EDN1
8 diastolic heart failure 10.3 REN EDN1 AGTR1
9 mandibulofacial dysostosis with alopecia 10.3 EDNRA EDN1
10 systolic heart failure 10.2 REN EDN1 AGTR1
11 chronic pulmonary heart disease 10.2 REN EDNRA EDN1
12 raynaud disease 10.2 TRIM21 EDN1 AGTR1
13 ureteral disease 10.2 SERPINE1 REN AGTR1
14 anhidrosis, isolated, with normal sweat glands 10.2 EDNRA EDN1
15 coronary artery vasospasm 10.2 REN KNG1 EDN1
16 hepatic vascular disease 10.2 SERPINE1 REN EDN1
17 urinary tract obstruction 10.2 SERPINE1 REN AGTR1
18 limited scleroderma 10.2 TRIM21 EDNRA EDN1
19 intracranial berry aneurysm 10.2 REN EDNRA EDN1
20 peripheral vascular disease 10.2 SERPINE1 REN EDN1
21 diffuse scleroderma 10.2 TRIM21 EDN1
22 corticosterone methyloxidase type i deficiency 10.2 STAR REN CYP11B2
23 steroid inherited metabolic disorder 10.2 STAR REN CYP11B2
24 portal hypertension 10.2 REN EDNRA EDN1 AGTR1
25 severe nonproliferative diabetic retinopathy 10.2 VEGFB REN
26 familial glucocorticoid deficiency 10.1 STAR REN CYP11B2
27 hypoadrenocorticism, familial 10.1 STAR REN CYP11B2
28 adrenal cortex disease 10.1 STAR REN CYP11B2
29 adrenal gland disease 10.1 STAR REN CYP11B2
30 renal artery disease 10.1 REN AGT
31 hypertensive heart disease 10.1 REN EDN1 CYP11B2 AGTR1
32 multicystic dysplastic kidney 10.1 REN AGTR1 AGT
33 potter's syndrome 10.1 REN AGTR1 AGT
34 fibromuscular dysplasia 10.1 REN AGTR1 AGT
35 anuria 10.1 REN AGTR1 AGT
36 adrenal carcinoma 10.1 STAR REN CYP11B2
37 renal tubular dysgenesis 10.1 REN AGTR1 AGT
38 eclampsia 10.1 REN EDN1 AGT
39 dic in newborn 10.1 SERPINE1 F7
40 hellp syndrome 10.1 SERPINE1 EDN1 CYP11B2
41 apnea, obstructive sleep 10.1 REN EDN1 AGT
42 obstructive nephropathy 10.1 SERPINE1 REN AGT
43 pulmonary valve insufficiency 10.1 REN EDN1
44 lipid metabolism disorder 10.0 STAR SERPINE1 REN EDN1
45 plantar fascial fibromatosis 10.0 AGTR1 AGT
46 retinal vein occlusion 10.0 SERPINE1 EDN1 ANGPT2
47 adrenal cortical carcinoma 10.0 STAR REN CYP11B2 AGTR1
48 aortic aneurysm, familial abdominal, 1 10.0 SERPINE1 REN AGTR1
49 hyperaldosteronism, familial, type i 10.0 REN CYP11B2 AGT
50 iga glomerulonephritis 10.0 REN AGTR1 AGT

Graphical network of the top 20 diseases related to Malignant Secondary Hypertension:



Diseases related to Malignant Secondary Hypertension
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Symptoms & Phenotypes for Malignant Secondary Hypertension

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GenomeRNAi Phenotypes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.17 AGT AGTR1 ANGPT1 ANGPT2 ARRB1 ASPH
2 no effect GR00402-S-2 10.17 AGT AGTR1 ANGPT2 ARRB1 ASPH EDN1

MGI Mouse Phenotypes related to Malignant Secondary Hypertension:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.32 AGT AGTR1 ANGPT1 ANGPT2 ARRB1 ASPH
2 nervous system MP:0003631 10.2 AGT AGTR1 ANGPT1 ARRB1 CYP11B2 EDN1
3 growth/size/body region MP:0005378 10.19 AGT AGTR1 ANGPT1 ARRB1 ASPH CYP11B2
4 renal/urinary system MP:0005367 10.17 AGT AGTR1 ANGPT1 CYP11B2 EDN1 EDNRA
5 muscle MP:0005369 10.1 AGT ANGPT1 ARRB1 ASPH CYP11B2 EDN1
6 cardiovascular system MP:0005385 10.03 AGT AGTR1 ANGPT1 ANGPT2 ARRB1 ASPH
7 adipose tissue MP:0005375 9.97 AGT AGTR1 CYP11B2 F7 SAG SERPINE1
8 immune system MP:0005387 9.73 AGT AGTR1 ANGPT1 ANGPT2 CYP11B2 EDNRA
9 mortality/aging MP:0010768 9.58 AGT AGTR1 ANGPT1 ANGPT2 ARRB1 ASPH
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Drugs & Therapeutics for Malignant Secondary Hypertension

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Search Clinical Trials, NIH Clinical Center for Malignant Secondary Hypertension

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Genetic Tests for Malignant Secondary Hypertension

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Anatomical Context for Malignant Secondary Hypertension

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Publications for Malignant Secondary Hypertension

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Articles related to Malignant Secondary Hypertension:

# Title Authors PMID Year
1
Autoantibodies against the angiotensin receptor (AT1) in patients with hypertension. 62
10930193 2000
2
Autoantibodies against cardiac G-protein-coupled receptors define different populations with cardiomyopathies but not with hypertension. 62
8020188 1994
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Variations for Malignant Secondary Hypertension

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Expression for Malignant Secondary Hypertension

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Search GEO for disease gene expression data for Malignant Secondary Hypertension.
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Pathways for Malignant Secondary Hypertension

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Pathways related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Signal Transduction 66
13.31 VEGFD VEGFB SERPINE1 NCF2 KNG1 EDNRA
2
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.92 ANGPT1 ANGPT2 ARRB1 F7 KNG1 SERPINE1
3
Immune response IL-23 signaling pathway 22
Show member pathways
 12.33 TIE1 ANGPT2 ANGPT1 AGTR1
4
Tyrosine Kinases / Adaptors 3
11.88 VEGFB TIE1 ARRB1 ANGPT2
5
Angiogenesis (CST) 3
11.58 VEGFB REN ANGPT2
6
HIF1Alpha Pathway 64
11.34 VEGFD VEGFB EDN1
7
ACE Inhibitor Pathway, Pharmacodynamics 60
Show member pathways
 11.16 SERPINE1 REN KNG1 CYP11B2 AGTR1 AGT
8
Hypothesized pathways in pathogenesis of cardiovascular disease 74
10.9 SERPINE1 ANGPT2 AGTR1
9
Photodynamic therapy-induced HIF-1 survival signaling 74
10.82 SERPINE1 EDN1 ANGPT2 ANGPT1
10
G-protein signaling_Rap2B regulation pathway 22
10.75 VEGFD VEGFB TIE1 NCF2 ANGPT2 ANGPT1
11
VEGF ligand-receptor interactions 66
Show member pathways
 10.68 VEGFD VEGFB
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GO Terms for Malignant Secondary Hypertension

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Cellular components related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.16 VEGFD VEGFB SERPINE1 REN KNG1 F7
2 collagen-containing extracellular matrix GO:0062023 9.73 SERPINE1 KNG1 F7 ANGPT2 ANGPT1 AGT
3 platelet alpha granule lumen GO:0031093 9.23 VEGFD VEGFB SERPINE1 KNG1

Biological processes related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 10.13 KNG1 EDNRA EDN1 AGTR1 AGT
2 positive chemotaxis GO:0050918 10.1 ANGPT1 VEGFB VEGFD
3 positive regulation of angiogenesis GO:0045766 10.1 ANGPT2 SERPINE1 TIE1 VEGFB VEGFD
4 regulation of blood pressure GO:0008217 10.08 AGT EDN1 EDNRA REN
5 sprouting angiogenesis GO:0002040 10.04 VEGFD VEGFB ANGPT1
6 angiogenesis GO:0001525 10.02 VEGFD TIE1 SERPINE1 EDNRA ANGPT2 ANGPT1
7 endothelin receptor signaling pathway GO:0086100 9.97 EDNRA EDN1
8 positive regulation of cation channel activity GO:2001259 9.97 EDNRA EDN1
9 regulation of vasoconstriction GO:0019229 9.97 EDN1 AGTR1 AGT
10 positive regulation of CoA-transferase activity GO:1905920 9.96 AGTR1 AGT
11 axonogenesis involved in innervation GO:0060385 9.96 EDNRA EDN1
12 regulation of glucose transmembrane transport GO:0010827 9.96 EDNRA EDN1
13 cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 9.95 EDN1 EDNRA
14 noradrenergic neuron differentiation GO:0003357 9.95 EDN1 EDNRA
15 positive regulation of NAD(P)H oxidase activity GO:0033864 9.94 AGT AGTR1
16 cellular response to luteinizing hormone stimulus GO:0071373 9.93 EDNRA EDN1
17 positive regulation of mast cell chemotaxis GO:0060754 9.93 VEGFD VEGFB
18 neural crest cell fate commitment GO:0014034 9.91 EDN1 EDNRA
19 regulation of renal sodium excretion GO:0035813 9.91 AGT AGTR1
20 Tie signaling pathway GO:0048014 9.9 ANGPT1 ANGPT2
21 glomerulus vasculature development GO:0072012 9.89 ANGPT1 ANGPT2
22 sympathetic neuron axon guidance GO:0097492 9.88 EDN1 EDNRA
23 regulation of extracellular matrix assembly GO:1901201 9.88 AGT TIE1
24 vasoconstriction GO:0042310 9.88 AGT EDN1 EDNRA
25 endothelin receptor signaling pathway involved in heart process GO:0086101 9.86 EDNRA EDN1
26 maintenance of blood vessel diameter homeostasis by renin-angiotensin GO:0002034 9.85 AGTR1 AGT
27 negative regulation of blood coagulation GO:0030195 9.85 SERPINE1 KNG1 EDN1
28 meiotic cell cycle process involved in oocyte maturation GO:1903537 9.83 EDNRA EDN1
29 regulation of endothelial cell proliferation GO:0001936 9.81 TIE1 ANGPT1
30 cellular response to human chorionic gonadotropin stimulus GO:0044751 9.81 EDNRA EDN1
31 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003081 9.79 AGTR1 AGT
32 artery smooth muscle contraction GO:0014824 9.73 AGT EDN1 EDNRA
33 response to hypoxia GO:0001666 9.7 VEGFD VEGFB F7 EDNRA EDN1 ANGPT2
34 regulation of blood volume by renin-angiotensin GO:0002016 9.63 REN AGT
35 blood vessel diameter maintenance GO:0097746 9.55 KNG1 EDN1 AGTR1 AGT
36 renin-angiotensin regulation of aldosterone production GO:0002018 9.1 REN AGTR1 AGT

Molecular functions related to Malignant Secondary Hypertension according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.44 SERPINE1 REN KNG1 F7 EDN1 ANGPT2
2 vascular endothelial growth factor receptor binding GO:0005172 9.26 VEGFD VEGFB
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Sources for Malignant Secondary Hypertension

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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