MCID: MLG021
MIFTS: 19

Malignant Sertoli-Leydig Cell Tumor

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Malignant Sertoli-Leydig Cell Tumor

MalaCards integrated aliases for Malignant Sertoli-Leydig Cell Tumor:

Name: Malignant Sertoli-Leydig Cell Tumor 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050618

Summaries for Malignant Sertoli-Leydig Cell Tumor

Disease Ontology : 12 A sex cord-gonadal stromal tumor characterized by variable proportions of Sertoli cells, Leydig cells, primitive gonadal stroma and/or heterologous elements located in the ovaries and testicles.

MalaCards based summary : Malignant Sertoli-Leydig Cell Tumor is related to malignant sertoli-leydig cell tumor of the ovary and liver lipoma. An important gene associated with Malignant Sertoli-Leydig Cell Tumor is AFP (Alpha Fetoprotein), and among its related pathways/superpathways is Myogenesis. Affiliated tissues include ovaries, ovary and liver.

Related Diseases for Malignant Sertoli-Leydig Cell Tumor

Diseases in the Sertoli-Leydig Cell Tumor family:

Malignant Sertoli-Leydig Cell Tumor

Diseases related to Malignant Sertoli-Leydig Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 malignant sertoli-leydig cell tumor of the ovary 12.8
2 liver lipoma 10.1 CEACAM5 AFP
3 urachal adenocarcinoma 10.1 CEACAM5 AFP
4 gestational ovarian choriocarcinoma 10.1 CEACAM5 AFP
5 immature teratoma of ovary 10.1 CEACAM5 AFP
6 mature teratoma 10.1 CEACAM5 AFP
7 teratoma 10.1 CEACAM5 AFP
8 rectum signet ring adenocarcinoma 10.1 CEACAM5 AFP
9 ovarian mixed germ cell neoplasm 10.1 CEACAM5 AFP
10 renal pelvis adenocarcinoma 10.1 CEACAM5 AFP
11 bile duct cystadenocarcinoma 10.1 CEACAM5 AFP
12 colonic lymphangioma 10.1 CEACAM5 AFP
13 liver lymphoma 10.1 CEACAM5 AFP
14 adult teratoma 10.0 CEACAM5 AFP
15 benign mesothelioma 10.0 CEACAM5 AFP
16 sarcomatous intrahepatic cholangiocarcinoma 10.0 CEACAM5 AFP
17 cholangiocarcinoma 10.0 CEACAM5 AFP
18 mediastinal cancer 10.0 CEACAM5 AFP
19 bile duct cysts 10.0 CEACAM5 AFP
20 ovarian benign neoplasm 10.0 CEACAM5 AFP
21 ovarian germ cell cancer 10.0 CEACAM5 AFP
22 malignant teratoma 10.0 CEACAM5 AFP
23 benign teratoma 10.0 CEACAM5 AFP
24 klatskin's tumor 10.0 CEACAM5 AFP
25 pineoblastoma 10.0 CEACAM5 AFP
26 sex cord-gonadal stromal tumor 10.0 CEACAM5 AFP
27 cystic teratoma 10.0 CEACAM5 AFP
28 myoblastoma 10.0 MYOG CEACAM5
29 tubular adenocarcinoma 10.0 CEACAM5 AFP
30 cystadenoma 9.9 CEACAM5 AFP
31 uterus leiomyosarcoma 9.9 MYOG CEACAM5
32 clear cell basal cell carcinoma 9.9 MYOG CEACAM5
33 bile duct adenocarcinoma 9.9 CEACAM5 AFP
34 bile duct disease 9.9 CEACAM5 AFP
35 gallbladder disease 9.8 CEACAM5 AFP
36 epididymal neoplasm 9.8 MYOD1 AFP
37 biliary tract disease 9.8 CEACAM5 AFP
38 undifferentiated embryonal sarcoma of the liver 9.8 MYOG MYOD1
39 embryonal sarcoma 9.8 MYOG MYOD1
40 skeletal muscle neoplasm 9.8 MYOG MYOD1
41 gallbladder sarcoma 9.7 MYOG MYOD1
42 malignant triton tumor 9.7 MYOG MYOD1
43 adult fibrosarcoma 9.7 MYOG MYOD1
44 prostate embryonal rhabdomyosarcoma 9.7 MYOG MYOD1
45 embryonal rhabdomyosarcoma 9.7 MYOG MYOD1
46 prostate stromal sarcoma 9.7 MYOG MYOD1
47 malignant mesenchymoma 9.7 MYOG MYOD1
48 mesenchymoma 9.7 MYOG MYOD1
49 extraosseous ewing sarcoma 9.7 MYOG MYOD1
50 spindle cell rhabdomyosarcoma 9.7 MYOG MYOD1

Graphical network of the top 20 diseases related to Malignant Sertoli-Leydig Cell Tumor:



Diseases related to Malignant Sertoli-Leydig Cell Tumor

Symptoms & Phenotypes for Malignant Sertoli-Leydig Cell Tumor

Drugs & Therapeutics for Malignant Sertoli-Leydig Cell Tumor

Search Clinical Trials , NIH Clinical Center for Malignant Sertoli-Leydig Cell Tumor

Genetic Tests for Malignant Sertoli-Leydig Cell Tumor

Anatomical Context for Malignant Sertoli-Leydig Cell Tumor

The Foundational Model of Anatomy Ontology organs/tissues related to Malignant Sertoli-Leydig Cell Tumor:

19
Ovaries

MalaCards organs/tissues related to Malignant Sertoli-Leydig Cell Tumor:

40
Ovary, Liver, Skeletal Muscle, Prostate, Colon, Breast, Uterus

Publications for Malignant Sertoli-Leydig Cell Tumor

Variations for Malignant Sertoli-Leydig Cell Tumor

Expression for Malignant Sertoli-Leydig Cell Tumor

Search GEO for disease gene expression data for Malignant Sertoli-Leydig Cell Tumor.

Pathways for Malignant Sertoli-Leydig Cell Tumor

Pathways related to Malignant Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.39 MYOG MYOD1

GO Terms for Malignant Sertoli-Leydig Cell Tumor

Biological processes related to Malignant Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cellular response to tumor necrosis factor GO:0071356 9.52 MYOD1 MYOG
2 muscle organ development GO:0007517 9.51 MYOD1 MYOG
3 skeletal muscle tissue development GO:0007519 9.49 MYOD1 MYOG
4 skeletal muscle cell differentiation GO:0035914 9.48 MYOD1 MYOG
5 cellular response to estradiol stimulus GO:0071392 9.46 MYOD1 MYOG
6 skeletal muscle fiber development GO:0048741 9.43 MYOD1 MYOG
7 positive regulation of muscle cell differentiation GO:0051149 9.4 MYOD1 MYOG
8 positive regulation of myoblast differentiation GO:0045663 9.37 MYOD1 MYOG
9 positive regulation of myoblast fusion GO:1901741 9.32 MYOD1 MYOG
10 myoblast differentiation GO:0045445 9.26 MYOD1 MYOG
11 myotube differentiation GO:0014902 9.16 MYOD1 MYOG
12 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOG MYOD1
13 muscle cell fate commitment GO:0042693 8.62 MYOG MYOD1

Molecular functions related to Malignant Sertoli-Leydig Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin DNA binding GO:0031490 8.96 MYOG MYOD1
2 E-box binding GO:0070888 8.62 MYOG MYOD1

Sources for Malignant Sertoli-Leydig Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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