MCID: MLG007
MIFTS: 37

Malignant Skin Fibrous Histiocytoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Malignant Skin Fibrous Histiocytoma

MalaCards integrated aliases for Malignant Skin Fibrous Histiocytoma:

Name: Malignant Skin Fibrous Histiocytoma 12 15
Vaginal Melanoma 12 17 74
Malignant Fibrous Histiocytoma of Skin 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1906
NCIt 51 C5576

Summaries for Malignant Skin Fibrous Histiocytoma

MalaCards based summary : Malignant Skin Fibrous Histiocytoma, also known as vaginal melanoma, is related to melanoma and giant congenital nevus. An important gene associated with Malignant Skin Fibrous Histiocytoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include skin, lung and myeloid, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Malignant Skin Fibrous Histiocytoma

Diseases related to Malignant Skin Fibrous Histiocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 melanoma 10.6
2 giant congenital nevus 10.4 HRAS NRAS
3 thymoma, familial 10.4 HRAS KIT
4 conventional fibrosarcoma 10.4 KIT NRAS
5 uterine inversion 10.4 F7 KIT
6 benign struma ovarii 10.4 HRAS NRAS
7 schimmelpenning-feuerstein-mims syndrome 10.4 HRAS NRAS
8 acral lentiginous melanoma 10.4 KIT NRAS
9 conjunctival cancer 10.4 IFNA2 NRAS
10 cutaneous ganglioneuroma 10.4 KIT NCAM1
11 melanomatosis 10.4 HRAS NRAS
12 aggressive digital papillary adenocarcinoma 10.3 HRAS KIT
13 aggressive systemic mastocytosis 10.3 IFNA2 KIT
14 marcus gunn phenomenon 10.3 HRAS NRAS
15 malignant spindle cell melanoma 10.3 KIT NRAS TYR
16 olfactory groove meningioma 10.3 CHGA F7
17 esophageal neuroendocrine tumor 10.3 CHGA NCAM1
18 ovarian large-cell neuroendocrine carcinoma 10.3 CHGA NCAM1
19 sarcomatoid renal cell carcinoma 10.3 IFNA2 KIT
20 lung adenoid cystic carcinoma 10.3 HRAS KIT
21 core binding factor acute myeloid leukemia 10.3 HRAS KIT NRAS
22 malignant conjunctival melanoma 10.3 HRAS IFNA2 NRAS
23 malignant struma ovarii 10.3 HRAS NRAS
24 gallbladder small cell carcinoma 10.3 CHGA NCAM1
25 melanocytic nevus syndrome, congenital 10.3 HRAS NRAS TYR
26 renal cell carcinoma, papillary, 1 10.3 HRAS KIT NRAS
27 nodular malignant melanoma 10.2 HRAS NRAS
28 inherited blood coagulation disease 10.2 F7 F9 ITGA2B
29 blood coagulation disease 10.2 F7 F9 ITGA2B
30 pancreatic serous cystadenoma 10.2 CHGA NCAM1
31 conventional angiosarcoma 10.2 CHGA NCAM1
32 apocrine adenoma 10.2 HRAS UBC
33 hemorrhagic disease 10.2 F7 F9 ITGA2B
34 malignant anus melanoma 10.2 KIT MLANA
35 halo nevi 10.2 MLANA TYR
36 mediastinal cancer 10.2 KIT NCAM1
37 small cell carcinoma 10.2 CHGA KIT NCAM1
38 pigmented basal cell carcinoma 10.2 MLANA TYR
39 large cell neuroendocrine carcinoma 10.2 CHGA KIT NCAM1
40 melanoacanthoma 10.2 MLANA TYR
41 merkel cell carcinoma 10.2 CHGA KIT NCAM1
42 parasitic ichthyosporea infectious disease 10.2 NCAM1 UBC
43 rhinosporidiosis 10.2 NCAM1 UBC
44 factor v deficiency 10.2 COX5A F7 F9
45 bone marrow cancer 10.2 HRAS IFNA2 KIT
46 angiomyoma 10.1 KIT NCAM1
47 thyroid cancer, nonmedullary, 2 10.1 CHGA HRAS NRAS
48 diffuse meningeal melanocytosis 10.1 MLANA TYR
49 melanoma, cutaneous malignant 1 10.1 HRAS IFNA2 KIT NRAS
50 epithelioid cell melanoma 10.1 MLANA TYR

Graphical network of the top 20 diseases related to Malignant Skin Fibrous Histiocytoma:



Diseases related to Malignant Skin Fibrous Histiocytoma

Symptoms & Phenotypes for Malignant Skin Fibrous Histiocytoma

GenomeRNAi Phenotypes related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CHGA F9 HRAS ITGA2B NCAM1 NRAS

MGI Mouse Phenotypes related to Malignant Skin Fibrous Histiocytoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 CHGA CTLA4 F7 F9 HRAS ITGA2B
2 no phenotypic analysis MP:0003012 9.56 CHGA F7 HRAS IFNB1 KIT MLANA
3 pigmentation MP:0001186 9.02 CTLA4 KIT MLANA NRAS TYR

Drugs & Therapeutics for Malignant Skin Fibrous Histiocytoma

Search Clinical Trials , NIH Clinical Center for Malignant Skin Fibrous Histiocytoma

Genetic Tests for Malignant Skin Fibrous Histiocytoma

Anatomical Context for Malignant Skin Fibrous Histiocytoma

MalaCards organs/tissues related to Malignant Skin Fibrous Histiocytoma:

42
Skin, Lung, Myeloid, Bone, Breast, Thyroid, Bone Marrow

Publications for Malignant Skin Fibrous Histiocytoma

Articles related to Malignant Skin Fibrous Histiocytoma:

(show all 48)
# Title Authors Year
1
Amelanotic primary vaginal melanoma: A case report with cyto-histological correlations. ( 30478998 )
2019
2
Response to imatinib in vaginal melanoma with KIT p.Val559Gly mutation previously treated with nivolumab, pembrolizumab and ipilimumab. ( 30614559 )
2019
3
Pigmented Conjunctival Lesions as Presenting Signs of Vaginal Melanoma. ( 30320085 )
2018
4
Vulvar and vaginal melanoma: A unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma. ( 28026870 )
2017
5
Cytology of primary vaginal melanoma: An unusual report on fine needle aspiration. ( 27863187 )
2017
6
Primary Vaginal Melanoma, A Rare and Aggressive Entity. A Case Report and Review of the Literature. ( 28064232 )
2017
7
A retrospective clinical analysis of 5 cases of vaginal melanoma. ( 28451415 )
2017
8
Primary Vaginal Melanoma With Rhabdoid Features: A Case Report and Literature Review. ( 28800579 )
2017
9
Locally Advanced Unresectable Vaginal Melanoma: Response With Anti-Programmed Death Receptor 1. ( 26704337 )
2016
10
MRI findings in primary vaginal melanoma-a report of four cases. ( 25560672 )
2015
11
Non-Cutaneous Melanomas of the Genital Tract: Minimally Invasive Robotic Treatment of Primary Vaginal Melanoma-Case Report. ( 27679160 )
2015
12
Vulvar/vaginal melanoma: an updated surveillance epidemiology and end results database review, comparison with cutaneous melanoma and significance of racial disparities. ( 23765206 )
2013
13
Vulvar and vaginal melanoma: case series and review of current management options including neoadjuvant chemotherapy. ( 23480869 )
2013
14
Treatment approach and outcomes of vaginal melanoma. ( 23945202 )
2013
15
Lumbosacral spondylodiscitis after sacral colpopexy of a sigmoid neovagina in a patient with vaginal melanoma. ( 22439780 )
2012
16
Topical treatment of recurrent vaginal melanoma in situ with imiquimod: A case report. ( 24371630 )
2012
17
Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature. ( 25258467 )
2012
18
Malignant vaginal melanoma with metastases to the papilla of Vater in a dialysis patient: a case report. ( 21325769 )
2011
19
Is recurrent vaginal melanoma a lethal disease? ( 21872810 )
2011
20
Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas. ( 20147857 )
2010
21
Primary vaginal melanoma: a case report and literature review. ( 18592798 )
2008
22
Treatment of recurrent vaginal melanoma with external beam radiation therapy and palladium-103 brachytherapy. ( 18778972 )
2008
23
Epidermodysplasia verruciformis and cutaneous human papillomavirus DNA, but not genital human papillomavirus DNAs, are frequently detected in vulvar and vaginal melanoma. ( 17284956 )
2007
24
Paraneoplastic syndrome in vaginal melanoma: a case report and review of the literature. ( 17309666 )
2007
25
Utility of sentinel node biopsy in vulvar and vaginal melanoma: report of two cases and review of the literature. ( 17343569 )
2007
26
Use of lymphoscintigraphy with SPECT/CT for sentinel node localization in a case of vaginal melanoma. ( 16550011 )
2006
27
Primary malignant vaginal melanoma treated with adriamycin and ifosfamide: a case report and literature review. ( 15863186 )
2005
28
Vaginal melanoma mimicking bladder FDG activity in a patient with chronic renal failure. ( 15891310 )
2005
29
Primary vaginal melanoma: a rare and problematic clinical entity. ( 14699024 )
2004
30
Primary vaginal melanoma: a critical analysis of therapy. ( 14699031 )
2004
31
Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. ( 12409721 )
2002
32
Sentinel node biopsy in vulvar and vaginal melanoma: presentation of six cases and a literature review. ( 12417504 )
2002
33
Periurethral vaginal melanoma: urine cytologic findings. ( 11284323 )
2001
34
Primary vaginal melanoma and long-term survivors. ( 11321487 )
2001
35
Vaginal melanoma masquerading as adenocarcinoma based on cervical cytology: a case report and review of the literature. ( 11194440 )
2000
36
Primary vaginal melanoma: thirteen-year disease-free survival after wide local excision and review of recent literature. ( 9662299 )
1998
37
Vaginal melanoma: a current review. ( 15512166 )
1998
38
Malignant vulvo-vaginal melanoma: a report of 7 cases. ( 9061328 )
1997
39
Malignant vaginal melanoma. Usefulness of fat-saturation MRI. ( 8744825 )
1996
40
Vaginal melanoma. ( 7557607 )
1995
41
Vaginal melanoma. ( 7557608 )
1995
42
Vaginal melanoma. Report of two cases and review of the literature. ( 7664765 )
1995
43
Vulvar and vaginal melanoma. A clinicopathologic study. ( 7884749 )
1994
44
Primary vaginal melanoma: improved survival with radical pelvic surgery. ( 7959290 )
1994
45
Vaginal melanoma and the role of regional chemotherapy. ( 8501907 )
1993
46
The management of vaginal melanoma. ( 3167819 )
1988
47
Vulvo-vaginal melanoma--should radical surgery be abandoned? ( 3580331 )
1987
48
Cytologic detection of recurrent vaginal melanoma. ( 281845 )
1978

Variations for Malignant Skin Fibrous Histiocytoma

Expression for Malignant Skin Fibrous Histiocytoma

Search GEO for disease gene expression data for Malignant Skin Fibrous Histiocytoma.

Pathways for Malignant Skin Fibrous Histiocytoma

Pathways related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CHGA CTLA4 HRAS IFNA2 IFNB1 ITGA2B
2
Show member pathways
13.37 HRAS IFNA2 IFNB1 ITGA2B KIT NRAS
3
Show member pathways
12.87 HRAS IFNA2 IFNB1 ITGA2B KIT NCAM1
4
Show member pathways
12.68 HRAS IFNA2 IFNB1 ITGA2B KIT NRAS
5
Show member pathways
12.64 CD99 F7 F9 HRAS IFNA2 IFNB1
6 12.58 HRAS IFNA2 ITGA2B KIT NRAS
7 12.4 CTLA4 KIT MLANA NCAM1
8
Show member pathways
12.35 IFNA2 IFNB1 NCAM1 UBC
9
Show member pathways
12.31 HRAS IFNA2 IFNB1 NRAS
10
Show member pathways
12.19 HRAS IFNA2 IFNB1 NRAS
11
Show member pathways
11.92 HRAS ITGA2B NRAS
12
Show member pathways
11.89 HRAS NRAS UBC
13
Show member pathways
11.78 HRAS NRAS UBC
14
Show member pathways
11.65 HRAS NRAS UBC
15 11.62 IFNA2 ITGA2B KIT NCAM1
16
Show member pathways
11.57 HRAS KIT NRAS
17 11.57 HRAS IFNA2 IFNB1 NRAS
18 11.42 HRAS KIT NRAS
19
Show member pathways
11.39 HRAS NRAS UBC
20 10.97 HRAS NRAS
21 10.94 ITGA2B NCAM1
22 10.91 HRAS NRAS
23 10.79 IFNA2 IFNB1 KIT NCAM1
24 10.75 F7 F9
25 10.66 HRAS NRAS

GO Terms for Malignant Skin Fibrous Histiocytoma

Cellular components related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 CHGA F7 F9 IFNA2 IFNB1 KIT
2 mast cell granule GO:0042629 9.16 CHGA KIT
3 external side of plasma membrane GO:0009897 8.92 CTLA4 ITGA2B KIT NCAM1

Biological processes related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.71 IFNA2 IFNB1 KIT UBC
2 MAPK cascade GO:0000165 9.67 HRAS KIT NCAM1 NRAS
3 blood coagulation GO:0007596 9.56 F7 F9 IFNA2 IFNB1
4 T cell activation involved in immune response GO:0002286 9.51 IFNA2 IFNB1
5 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.49 IFNA2 IFNB1
6 natural killer cell activation involved in immune response GO:0002323 9.48 IFNA2 IFNB1
7 mast cell degranulation GO:0043303 9.46 CHGA KIT
8 positive regulation of phospholipase C activity GO:0010863 9.43 HRAS KIT
9 negative regulation of T cell differentiation GO:0045581 9.32 IFNA2 IFNB1
10 mast cell chemotaxis GO:0002551 9.16 CHGA KIT
11 negative regulation of T-helper 2 cell cytokine production GO:2000552 8.96 IFNA2 IFNB1
12 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 type I interferon receptor binding GO:0005132 8.62 IFNA2 IFNB1

Sources for Malignant Skin Fibrous Histiocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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