MCID: MLG007
MIFTS: 35

Malignant Skin Fibrous Histiocytoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Malignant Skin Fibrous Histiocytoma

MalaCards integrated aliases for Malignant Skin Fibrous Histiocytoma:

Name: Malignant Skin Fibrous Histiocytoma 12 15
Vaginal Melanoma 12 17 74
Malignant Fibrous Histiocytoma of Skin 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:1906
NCIt 51 C5576

Summaries for Malignant Skin Fibrous Histiocytoma

MalaCards based summary : Malignant Skin Fibrous Histiocytoma, also known as vaginal melanoma, is related to melanoma and conventional fibrosarcoma. An important gene associated with Malignant Skin Fibrous Histiocytoma is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are TGF-Beta Pathway and Cytokine Signaling in Immune system. Affiliated tissues include skin, and related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Malignant Skin Fibrous Histiocytoma

Diseases related to Malignant Skin Fibrous Histiocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 melanoma 10.6
2 conventional fibrosarcoma 10.4 KIT NRAS
3 giant congenital nevus 10.4 HRAS NRAS
4 thymoma, familial 10.4 HRAS KIT
5 uterine inversion 10.4 F7 KIT
6 liver leiomyosarcoma 10.4 CHGA SMUG1
7 schimmelpenning-feuerstein-mims syndrome 10.3 HRAS NRAS
8 acral lentiginous melanoma 10.3 KIT NRAS
9 conjunctival cancer 10.3 IFNA2 NRAS
10 cellular ependymoma 10.3 CHGA SMUG1
11 melanomatosis 10.3 HRAS NRAS
12 cutaneous ganglioneuroma 10.3 KIT NCAM1
13 gastrointestinal neuroendocrine tumor 10.3 CHGA SMUG1
14 aggressive digital papillary adenocarcinoma 10.3 HRAS KIT
15 malignant spindle cell melanoma 10.3 KIT NRAS TYR
16 aggressive systemic mastocytosis 10.3 IFNA2 KIT
17 marcus gunn phenomenon 10.3 HRAS NRAS
18 core binding factor acute myeloid leukemia 10.3 HRAS KIT NRAS
19 spinal cord melanoma 10.3 IFNB1 SMUG1
20 olfactory groove meningioma 10.3 CHGA F7
21 malignant conjunctival melanoma 10.3 HRAS IFNA2 NRAS
22 esophageal neuroendocrine tumor 10.3 CHGA NCAM1
23 benign struma ovarii 10.3 HRAS NRAS SMUG1
24 ovarian large-cell neuroendocrine carcinoma 10.3 CHGA NCAM1
25 melanocytic nevus syndrome, congenital 10.2 HRAS NRAS TYR
26 lung adenoid cystic carcinoma 10.2 HRAS KIT
27 renal cell carcinoma, papillary, 1 10.2 HRAS KIT NRAS
28 gastrointestinal system cancer 10.2 HRAS KIT SMUG1
29 mediastinal cancer 10.2 KIT NCAM1 SMUG1
30 malignant struma ovarii 10.2 HRAS NRAS
31 malignant anus melanoma 10.2 KIT MLANA
32 inherited blood coagulation disease 10.2 F7 F9 ITGA2B
33 granulomatous myositis 10.2 NCAM1 SMUG1
34 blood coagulation disease 10.2 F7 F9 ITGA2B
35 leukocyte disease 10.2 KIT NCAM1 SMUG1
36 apocrine adenoma 10.2 HRAS UBC
37 gastrointestinal system disease 10.2 HRAS KIT SMUG1
38 halo nevi 10.2 MLANA TYR
39 sarcomatoid renal cell carcinoma 10.2 IFNA2 KIT
40 hemorrhagic disease 10.2 F7 F9 ITGA2B
41 brain sarcoma 10.2 MLANA SMUG1
42 pancreatic serous cystadenoma 10.2 CHGA NCAM1
43 conventional angiosarcoma 10.2 CHGA NCAM1
44 pigmented basal cell carcinoma 10.2 MLANA TYR
45 cecum adenocarcinoma 10.2 CHGA HRAS SMUG1
46 orbital plasma cell granuloma 10.2 IFNA2 NCAM1
47 melanoacanthoma 10.2 MLANA TYR
48 nodular malignant melanoma 10.2 HRAS NRAS
49 small cell carcinoma 10.2 CHGA KIT NCAM1
50 large cell neuroendocrine carcinoma 10.1 CHGA KIT NCAM1

Graphical network of the top 20 diseases related to Malignant Skin Fibrous Histiocytoma:



Diseases related to Malignant Skin Fibrous Histiocytoma

Symptoms & Phenotypes for Malignant Skin Fibrous Histiocytoma

GenomeRNAi Phenotypes related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.1 CHGA F9 HRAS ITGA2B NCAM1 NRAS

MGI Mouse Phenotypes related to Malignant Skin Fibrous Histiocytoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.76 CHGA F7 F9 HRAS ITGA2B KIT
2 neoplasm MP:0002006 9.43 HRAS IFNB1 KIT NRAS SMUG1 TYR
3 no phenotypic analysis MP:0003012 9.23 CHGA F7 HRAS IFNB1 KIT MLANA

Drugs & Therapeutics for Malignant Skin Fibrous Histiocytoma

Search Clinical Trials , NIH Clinical Center for Malignant Skin Fibrous Histiocytoma

Genetic Tests for Malignant Skin Fibrous Histiocytoma

Anatomical Context for Malignant Skin Fibrous Histiocytoma

MalaCards organs/tissues related to Malignant Skin Fibrous Histiocytoma:

42
Skin

Publications for Malignant Skin Fibrous Histiocytoma

Articles related to Malignant Skin Fibrous Histiocytoma:

(show all 48)
# Title Authors Year
1
Response to imatinib in vaginal melanoma with KIT p.Val559Gly mutation previously treated with nivolumab, pembrolizumab and ipilimumab. ( 30614559 )
2019
2
Amelanotic primary vaginal melanoma: A case report with cyto-histological correlations. ( 30478998 )
2018
3
Pigmented Conjunctival Lesions as Presenting Signs of Vaginal Melanoma. ( 30320085 )
2018
4
Primary Vaginal Melanoma With Rhabdoid Features: A Case Report and Literature Review. ( 28800579 )
2017
5
Cytology of primary vaginal melanoma: An unusual report on fine needle aspiration. ( 27863187 )
2017
6
Primary Vaginal Melanoma, A Rare and Aggressive Entity. A Case Report and Review of the Literature. ( 28064232 )
2017
7
A retrospective clinical analysis of 5 cases of vaginal melanoma. ( 28451415 )
2017
8
Vulvar and vaginal melanoma: A unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma. ( 28026870 )
2016
9
Locally Advanced Unresectable Vaginal Melanoma: Response With Anti-Programmed Death Receptor 1. ( 26704337 )
2016
10
MRI findings in primary vaginal melanoma-a report of four cases. ( 25560672 )
2015
11
Non-Cutaneous Melanomas of the Genital Tract: Minimally Invasive Robotic Treatment of Primary Vaginal Melanoma-Case Report. ( 27679160 )
2015
12
Vulvar/vaginal melanoma: an updated surveillance epidemiology and end results database review, comparison with cutaneous melanoma and significance of racial disparities. ( 23765206 )
2013
13
Vulvar and vaginal melanoma: case series and review of current management options including neoadjuvant chemotherapy. ( 23480869 )
2013
14
Treatment approach and outcomes of vaginal melanoma. ( 23945202 )
2013
15
Lumbosacral spondylodiscitis after sacral colpopexy of a sigmoid neovagina in a patient with vaginal melanoma. ( 22439780 )
2012
16
Topical treatment of recurrent vaginal melanoma in situ with imiquimod: A case report. ( 24371630 )
2012
17
Primary Malignant Vaginal Melanoma - Case Report and Review of the Literature. ( 25258467 )
2012
18
Malignant vaginal melanoma with metastases to the papilla of Vater in a dialysis patient: a case report. ( 21325769 )
2011
19
Is recurrent vaginal melanoma a lethal disease? ( 21872810 )
2011
20
Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas. ( 20147857 )
2010
21
Primary vaginal melanoma: a case report and literature review. ( 18592798 )
2008
22
Treatment of recurrent vaginal melanoma with external beam radiation therapy and palladium-103 brachytherapy. ( 18778972 )
2008
23
Epidermodysplasia verruciformis and cutaneous human papillomavirus DNA, but not genital human papillomavirus DNAs, are frequently detected in vulvar and vaginal melanoma. ( 17284956 )
2007
24
Paraneoplastic syndrome in vaginal melanoma: a case report and review of the literature. ( 17309666 )
2007
25
Utility of sentinel node biopsy in vulvar and vaginal melanoma: report of two cases and review of the literature. ( 17343569 )
2007
26
Use of lymphoscintigraphy with SPECT/CT for sentinel node localization in a case of vaginal melanoma. ( 16550011 )
2006
27
Primary malignant vaginal melanoma treated with adriamycin and ifosfamide: a case report and literature review. ( 15863186 )
2005
28
Vaginal melanoma mimicking bladder FDG activity in a patient with chronic renal failure. ( 15891310 )
2005
29
Primary vaginal melanoma: a rare and problematic clinical entity. ( 14699024 )
2004
30
Primary vaginal melanoma: a critical analysis of therapy. ( 14699031 )
2004
31
Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. ( 12409721 )
2002
32
Sentinel node biopsy in vulvar and vaginal melanoma: presentation of six cases and a literature review. ( 12417504 )
2002
33
Periurethral vaginal melanoma: urine cytologic findings. ( 11284323 )
2001
34
Primary vaginal melanoma and long-term survivors. ( 11321487 )
2001
35
Vaginal melanoma masquerading as adenocarcinoma based on cervical cytology: a case report and review of the literature. ( 11194440 )
2000
36
Primary vaginal melanoma: thirteen-year disease-free survival after wide local excision and review of recent literature. ( 9662299 )
1998
37
Vaginal melanoma: a current review. ( 15512166 )
1998
38
Malignant vulvo-vaginal melanoma: a report of 7 cases. ( 9061328 )
1997
39
Malignant vaginal melanoma. Usefulness of fat-saturation MRI. ( 8744825 )
1996
40
Vaginal melanoma. ( 7557607 )
1995
41
Vaginal melanoma. ( 7557608 )
1995
42
Vaginal melanoma. Report of two cases and review of the literature. ( 7664765 )
1995
43
Vulvar and vaginal melanoma. A clinicopathologic study. ( 7884749 )
1994
44
Primary vaginal melanoma: improved survival with radical pelvic surgery. ( 7959290 )
1994
45
Vaginal melanoma and the role of regional chemotherapy. ( 8501907 )
1993
46
The management of vaginal melanoma. ( 3167819 )
1988
47
Vulvo-vaginal melanoma--should radical surgery be abandoned? ( 3580331 )
1987
48
Cytologic detection of recurrent vaginal melanoma. ( 281845 )
1978

Variations for Malignant Skin Fibrous Histiocytoma

Expression for Malignant Skin Fibrous Histiocytoma

Search GEO for disease gene expression data for Malignant Skin Fibrous Histiocytoma.

Pathways for Malignant Skin Fibrous Histiocytoma

Pathways related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.35 HRAS IFNA2 IFNB1 ITGA2B KIT NRAS
2
Show member pathways
12.87 HRAS IFNA2 IFNB1 ITGA2B KIT NCAM1
3
Show member pathways
12.68 HRAS IFNA2 IFNB1 ITGA2B KIT NRAS
4
Show member pathways
12.64 CD99 F7 F9 HRAS IFNA2 IFNB1
5 12.58 HRAS IFNA2 ITGA2B KIT NRAS
6
Show member pathways
12.33 IFNA2 IFNB1 NCAM1 UBC
7
Show member pathways
12.29 HRAS IFNA2 IFNB1 NRAS
8
Show member pathways
12.16 HRAS IFNA2 IFNB1 NRAS
9
Show member pathways
11.9 HRAS ITGA2B NRAS
10
Show member pathways
11.87 HRAS NRAS UBC
11
Show member pathways
11.76 HRAS NRAS UBC
12 11.62 IFNA2 ITGA2B KIT NCAM1
13
Show member pathways
11.57 HRAS KIT NRAS
14 11.57 HRAS IFNA2 IFNB1 NRAS
15 11.42 HRAS KIT NRAS
16
Show member pathways
11.39 HRAS NRAS UBC
17 10.92 ITGA2B NCAM1
18 10.88 HRAS NRAS
19 10.79 IFNA2 IFNB1 KIT NCAM1
20 10.73 F7 F9
21 10.64 HRAS NRAS

GO Terms for Malignant Skin Fibrous Histiocytoma

Cellular components related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 CHGA F7 F9 IFNA2 IFNB1 KIT

Biological processes related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.71 IFNA2 IFNB1 KIT UBC
2 MAPK cascade GO:0000165 9.67 HRAS KIT NCAM1 NRAS
3 blood coagulation GO:0007596 9.56 F7 F9 IFNA2 IFNB1
4 positive regulation of peptidyl-serine phosphorylation of STAT protein GO:0033141 9.49 IFNA2 IFNB1
5 natural killer cell activation involved in immune response GO:0002323 9.48 IFNA2 IFNB1
6 mast cell degranulation GO:0043303 9.46 CHGA KIT
7 positive regulation of phospholipase C activity GO:0010863 9.43 HRAS KIT
8 negative regulation of T cell differentiation GO:0045581 9.32 IFNA2 IFNB1
9 mast cell chemotaxis GO:0002551 9.16 CHGA KIT
10 negative regulation of T-helper 2 cell cytokine production GO:2000552 8.96 IFNA2 IFNB1
11 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 type I interferon receptor binding GO:0005132 8.62 IFNA2 IFNB1

Sources for Malignant Skin Fibrous Histiocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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