MCID: MLG007
MIFTS: 35

Malignant Skin Fibrous Histiocytoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Malignant Skin Fibrous Histiocytoma

MalaCards integrated aliases for Malignant Skin Fibrous Histiocytoma:

Name: Malignant Skin Fibrous Histiocytoma 12 15
Malignant Fibrous Histiocytoma of Skin 12 73
Vaginal Melanoma 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1906
NCIt 50 C5576

Summaries for Malignant Skin Fibrous Histiocytoma

MalaCards based summary : Malignant Skin Fibrous Histiocytoma, also known as malignant fibrous histiocytoma of skin, is related to conventional fibrosarcoma and giant congenital nevus. An important gene associated with Malignant Skin Fibrous Histiocytoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PI3K-Akt signaling pathway. Affiliated tissues include skin, bone and lung, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Malignant Skin Fibrous Histiocytoma

Diseases related to Malignant Skin Fibrous Histiocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 conventional fibrosarcoma 10.3 KIT NRAS
2 giant congenital nevus 10.2 HRAS NRAS
3 thymoma, familial 10.2 HRAS KIT
4 liver leiomyosarcoma 10.2 CHGA SMUG1
5 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS NRAS
6 rectosigmoid junction neoplasm 10.2 KCNJ11 SMUG1
7 acral lentiginous melanoma 10.2 KIT NRAS
8 malignant spindle cell melanoma 10.2 KIT NRAS TYR
9 conjunctival cancer 10.2 IFNA2 NRAS
10 cellular ependymoma 10.2 CHGA SMUG1
11 melanomatosis 10.2 HRAS NRAS
12 aggressive digital papillary adenocarcinoma 10.2 HRAS KIT
13 gastrointestinal neuroendocrine tumor 10.2 CHGA SMUG1
14 aggressive systemic mastocytosis 10.2 IFNA2 KIT
15 marcus gunn phenomenon 10.2 HRAS NRAS
16 melanoma 10.2
17 cutaneous ganglioneuroma 10.2 KIT NCAM1
18 uterine inversion 10.2 F7 KCNJ11 KIT
19 core binding factor acute myeloid leukemia 10.2 HRAS KIT NRAS
20 malignant conjunctival melanoma 10.2 HRAS IFNA2 NRAS
21 benign struma ovarii 10.2 HRAS NRAS SMUG1
22 olfactory groove meningioma 10.2 CHGA F7
23 thymic epithelial tumor 10.2 CD99 KIT
24 renal cell carcinoma, papillary, 1 10.1 HRAS KIT NRAS
25 melanocytic nevus syndrome, congenital 10.1 HRAS NRAS TYR
26 gastrointestinal system cancer 10.1 HRAS KIT SMUG1
27 lung adenoid cystic carcinoma 10.1 HRAS KIT
28 inherited blood coagulation disease 10.1 F7 F9 ITGA2B
29 blood coagulation disease 10.1 F7 F9 ITGA2B
30 secondary hypertrophic osteoarthropathy 10.1 HRAS KCNJ11 SMUG1
31 apocrine adenoma 10.1 HRAS UBC
32 esophageal neuroendocrine tumor 10.1 CHGA NCAM1
33 gastrointestinal system disease 10.1 HRAS KIT SMUG1
34 ovarian large-cell neuroendocrine carcinoma 10.1 CHGA NCAM1
35 malignant struma ovarii 10.1 HRAS NRAS
36 hemorrhagic disease 10.1 F7 F9 ITGA2B
37 mediastinal cancer 10.1 KIT NCAM1 SMUG1
38 leukocyte disease 10.1 KIT NCAM1 SMUG1
39 cecum adenocarcinoma 10.1 CHGA HRAS SMUG1
40 granulomatous myositis 10.1 NCAM1 SMUG1
41 melanoma, cutaneous malignant 1 10.1 HRAS IFNA2 KIT NRAS
42 intracranial primitive neuroectodermal tumor 10.1 CD99 CHGA
43 thymoma 10.1 CTLA4 HRAS KIT
44 leukemia, chronic myeloid 10.1 HRAS IFNA2 KIT NRAS
45 malignant anus melanoma 10.1 KIT MLANA
46 endocrine gland cancer 10.1 CHGA HRAS SMUG1
47 connective tissue cancer 10.1 CD99 KIT SMUG1
48 small cell carcinoma 10.1 CHGA KIT NCAM1
49 pancreatic serous cystadenoma 10.0 CHGA NCAM1
50 halo nevi 10.0 MLANA TYR

Graphical network of the top 20 diseases related to Malignant Skin Fibrous Histiocytoma:



Diseases related to Malignant Skin Fibrous Histiocytoma

Symptoms & Phenotypes for Malignant Skin Fibrous Histiocytoma

GenomeRNAi Phenotypes related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.23 CHGA F9 HRAS ITGA2B KCNJ11 NCAM1

MGI Mouse Phenotypes related to Malignant Skin Fibrous Histiocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 CHGA CTLA4 F7 F9 HRAS ITGA2B
2 cardiovascular system MP:0005385 10.07 CHGA CTLA4 F7 F9 HRAS ITGA2B
3 mortality/aging MP:0010768 10.03 CHGA CTLA4 F7 F9 HRAS KCNJ11
4 neoplasm MP:0002006 9.63 HRAS KIT NRAS NUDT1 SMUG1 TYR
5 no phenotypic analysis MP:0003012 9.56 CHGA F7 HRAS KCNJ11 KIT MLANA
6 pigmentation MP:0001186 9.1 CTLA4 KCNJ11 KIT MLANA NRAS TYR

Drugs & Therapeutics for Malignant Skin Fibrous Histiocytoma

Search Clinical Trials , NIH Clinical Center for Malignant Skin Fibrous Histiocytoma

Genetic Tests for Malignant Skin Fibrous Histiocytoma

Anatomical Context for Malignant Skin Fibrous Histiocytoma

MalaCards organs/tissues related to Malignant Skin Fibrous Histiocytoma:

41
Skin, Bone, Lung, Liver, Thymus, Myeloid, Bone Marrow

Publications for Malignant Skin Fibrous Histiocytoma

Articles related to Malignant Skin Fibrous Histiocytoma:

# Title Authors Year
1
Amelanotic primary vaginal melanoma: A case report with cyto-histological correlations. ( 30478998 )
2018
2
Pigmented Conjunctival Lesions as Presenting Signs of Vaginal Melanoma. ( 30320085 )
2018
3
Vulvar and vaginal melanoma: A unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma. ( 28026870 )
2016
4
Vulvar/vaginal melanoma: an updated surveillance epidemiology and end results database review, comparison with cutaneous melanoma and significance of racial disparities. ( 23765206 )
2013
5
Epidermodysplasia verruciformis and cutaneous human papillomavirus DNA, but not genital human papillomavirus DNAs, are frequently detected in vulvar and vaginal melanoma. ( 17284956 )
2007
6
Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. ( 12409721 )
2002

Variations for Malignant Skin Fibrous Histiocytoma

Expression for Malignant Skin Fibrous Histiocytoma

Search GEO for disease gene expression data for Malignant Skin Fibrous Histiocytoma.

Pathways for Malignant Skin Fibrous Histiocytoma

Pathways related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 HRAS IFNA2 ITGA2B KIT NCAM1 NRAS
2
Show member pathways
12.79 HRAS IFNA2 ITGA2B KIT NRAS
3
Show member pathways
12.58 CD99 F7 F9 HRAS IFNA2 ITGA2B
4 12.52 HRAS IFNA2 ITGA2B KIT NRAS
5 12.35 CTLA4 KIT MLANA NCAM1
6
Show member pathways
12.16 HRAS KIT NRAS TYR
7 11.88 HRAS IFNA2 NRAS
8
Show member pathways
11.87 HRAS NRAS UBC
9
Show member pathways
11.73 HRAS NRAS UBC
10 11.68 HRAS IFNA2 NRAS
11
Show member pathways
11.62 HRAS NRAS UBC
12
Show member pathways
11.53 HRAS KIT NRAS
13 11.41 IFNA2 KIT NCAM1
14 11.31 HRAS KIT NRAS
15
Show member pathways
11.25 HRAS NRAS UBC
16 10.99 IFNA2 ITGA2B KIT NCAM1
17 10.87 HRAS NRAS
18 10.69 F7 F9
19 10.61 HRAS NRAS

GO Terms for Malignant Skin Fibrous Histiocytoma

Cellular components related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 CTLA4 ITGA2B KIT NCAM1
2 plasma membrane GO:0005886 9.4 CD99 CTLA4 F7 F9 HRAS ITGA2B
3 acrosomal vesicle GO:0001669 9.13 KCNJ11 KIT NUDT1

Biological processes related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.46 HRAS KIT NCAM1 NRAS
2 mast cell degranulation GO:0043303 9.32 CHGA KIT
3 positive regulation of phospholipase C activity GO:0010863 9.26 HRAS KIT
4 mast cell chemotaxis GO:0002551 8.96 CHGA KIT
5 mast cell cytokine production GO:0032762 8.62 CHGA KIT

Molecular functions related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.5 CD99 CTLA4 F7 F9 HRAS IFNA2

Sources for Malignant Skin Fibrous Histiocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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