MCID: MLG007
MIFTS: 32

Malignant Skin Fibrous Histiocytoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Malignant Skin Fibrous Histiocytoma

MalaCards integrated aliases for Malignant Skin Fibrous Histiocytoma:

Name: Malignant Skin Fibrous Histiocytoma 12 15
Malignant Fibrous Histiocytoma of Skin 12 73
Vaginal Melanoma 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:1906
NCIt 50 C5576
SNOMED-CT 68 404014008

Summaries for Malignant Skin Fibrous Histiocytoma

MalaCards based summary : Malignant Skin Fibrous Histiocytoma, also known as malignant fibrous histiocytoma of skin, is related to thymoma, familial and giant congenital nevus. An important gene associated with Malignant Skin Fibrous Histiocytoma is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. Affiliated tissues include skin, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Malignant Skin Fibrous Histiocytoma

Diseases related to Malignant Skin Fibrous Histiocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 thymoma, familial 10.9 HRAS KIT
2 giant congenital nevus 10.9 HRAS NRAS
3 schimmelpenning-feuerstein-mims syndrome 10.8 HRAS NRAS
4 sarcomatoid renal cell carcinoma 10.8 IFNA2 KIT
5 liver leiomyosarcoma 10.8 CHGA SMUG1
6 aggressive digital papillary adenocarcinoma 10.7 HRAS KIT
7 melanomatosis 10.7 HRAS NRAS
8 conjunctival cancer 10.7 IFNA2 NRAS
9 malignant spindle cell melanoma 10.7 KIT NRAS TYR
10 marcus gunn phenomenon 10.7 HRAS NRAS
11 cellular ependymoma 10.7 CHGA SMUG1
12 rectosigmoid junction neoplasm 10.7 KCNJ11 SMUG1
13 gastrointestinal neuroendocrine tumor 10.7 CHGA SMUG1
14 core binding factor acute myeloid leukemia 10.6 HRAS KIT NRAS
15 malignant conjunctival melanoma 10.6 HRAS IFNA2 NRAS
16 cutaneous ganglioneuroma 10.6 KIT NCAM1
17 benign struma ovarii 10.6 HRAS NRAS SMUG1
18 olfactory groove meningioma 10.6 CHGA F7
19 melanocytic nevus syndrome, congenital 10.6 HRAS NRAS TYR
20 renal cell carcinoma, papillary, 1 10.6 HRAS KIT NRAS
21 spinal cord melanoma 10.6 IFNB1 SMUG1
22 melanoma, cutaneous malignant 1 10.6 HRAS IFNA2 NRAS
23 conventional fibrosarcoma 10.6 KIT NRAS
24 uterine inversion 10.6 F7 KCNJ11 KIT
25 gastrointestinal system cancer 10.5 HRAS KIT SMUG1
26 secondary hypertrophic osteoarthropathy 10.5 HRAS SMUG1
27 thymic epithelial tumor 10.5 CD99 KIT
28 esophageal neuroendocrine tumor 10.5 CHGA NCAM1
29 aggressive systemic mastocytosis 10.5 IFNA2 KIT
30 apocrine adenoma 10.5 HRAS UBC
31 ovarian large-cell neuroendocrine carcinoma 10.5 CHGA NCAM1
32 inherited blood coagulation disease 10.5 F7 F9 ITGA2B
33 mediastinal cancer 10.4 KIT NCAM1 SMUG1
34 blood coagulation disease 10.4 F7 F9 ITGA2B
35 cecum adenocarcinoma 10.4 CHGA HRAS SMUG1
36 hemorrhagic disease 10.4 F7 F9 ITGA2B
37 endocrine gland cancer 10.4 CHGA HRAS SMUG1
38 bone marrow cancer 10.3 HRAS IFNA2 KIT
39 thymoma 10.3 CTLA4 HRAS KIT
40 leukemia, chronic myeloid 10.3 HRAS IFNA2 KIT NRAS
41 pancreatic serous cystadenoma 10.3 CHGA NCAM1
42 malignant struma ovarii 10.3 HRAS NRAS
43 acral lentiginous melanoma 10.3 KIT NRAS
44 autoimmune lymphoproliferative syndrome 10.3 CTLA4 HRAS NRAS
45 conventional angiosarcoma 10.3 CHGA NCAM1
46 granulomatous myositis 10.3 NCAM1 SMUG1
47 intracranial primitive neuroectodermal tumor 10.3 CD99 CHGA
48 large cell neuroendocrine carcinoma 10.3 CHGA KIT NCAM1
49 gallbladder small cell carcinoma 10.3 CHGA NCAM1 SMUG1
50 small cell carcinoma 10.2 CHGA KIT NCAM1

Graphical network of the top 20 diseases related to Malignant Skin Fibrous Histiocytoma:



Diseases related to Malignant Skin Fibrous Histiocytoma

Symptoms & Phenotypes for Malignant Skin Fibrous Histiocytoma

GenomeRNAi Phenotypes related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CHGA F9 HRAS ITGA2B KCNJ11 NCAM1

MGI Mouse Phenotypes related to Malignant Skin Fibrous Histiocytoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.1 F7 F9 NRAS SMUG1 HRAS IFNB1
2 cardiovascular system MP:0005385 10.07 F9 NRAS HRAS TYR ITGA2B KCNJ11
3 mortality/aging MP:0010768 10.03 NCAM1 F7 F9 NRAS SMUG1 HRAS
4 neoplasm MP:0002006 9.63 NRAS SMUG1 HRAS IFNB1 TYR KIT
5 no phenotypic analysis MP:0003012 9.61 NRAS HRAS TYR IFNB1 KCNJ11 CHGA
6 pigmentation MP:0001186 9.1 NRAS TYR KCNJ11 KIT CTLA4 MLANA

Drugs & Therapeutics for Malignant Skin Fibrous Histiocytoma

Search Clinical Trials , NIH Clinical Center for Malignant Skin Fibrous Histiocytoma

Genetic Tests for Malignant Skin Fibrous Histiocytoma

Anatomical Context for Malignant Skin Fibrous Histiocytoma

MalaCards organs/tissues related to Malignant Skin Fibrous Histiocytoma:

41
Skin

Publications for Malignant Skin Fibrous Histiocytoma

Articles related to Malignant Skin Fibrous Histiocytoma:

# Title Authors Year
1
Vulvar and vaginal melanoma: A unique subclass of mucosal melanoma based on a comprehensive molecular analysis of 51 cases compared with 2253 cases of nongynecologic melanoma. ( 28026870 )
2016
2
Comparison of molecular abnormalities in vulvar and vaginal melanomas. ( 24603591 )
2014
3
Epidermodysplasia verruciformis and cutaneous human papillomavirus DNA, but not genital human papillomavirus DNAs, are frequently detected in vulvar and vaginal melanoma. ( 17284956 )
2007
4
Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. ( 12409721 )
2002

Variations for Malignant Skin Fibrous Histiocytoma

Expression for Malignant Skin Fibrous Histiocytoma

Search GEO for disease gene expression data for Malignant Skin Fibrous Histiocytoma.

Pathways for Malignant Skin Fibrous Histiocytoma

Pathways related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.88 CHGA CTLA4 HRAS IFNA2 IFNB1 ITGA2B
2
Show member pathways
13.29 HRAS IFNA2 IFNB1 ITGA2B KIT NRAS
3
Show member pathways
12.87 HRAS IFNA2 IFNB1 ITGA2B KIT NCAM1
4
Show member pathways
12.71 HRAS IFNA2 IFNB1 ITGA2B KIT NRAS
5
Show member pathways
12.64 CD99 F7 F9 HRAS IFNA2 IFNB1
6 12.6 HRAS IFNA2 ITGA2B KIT NRAS
7
Show member pathways
12.42 HRAS IFNA2 IFNB1 NRAS
8 12.41 CTLA4 KIT MLANA NCAM1
9
Show member pathways
12.36 IFNA2 IFNB1 NCAM1 UBC
10
Show member pathways
12.32 HRAS IFNA2 IFNB1 NRAS
11
Show member pathways
11.79 HRAS NRAS UBC
12 11.74 HRAS IFNA2 IFNB1 NRAS
13
Show member pathways
11.66 HRAS NRAS UBC
14 11.62 IFNA2 ITGA2B KIT NCAM1
15 11.61 HRAS IFNA2 IFNB1 NRAS
16
Show member pathways
11.59 HRAS KIT NRAS
17 11.45 HRAS KIT NRAS
18
Show member pathways
11.42 HRAS NRAS UBC
19 10.79 IFNA2 IFNB1 KIT NCAM1
20 10.73 F7 F9
21 10.65 HRAS NRAS

GO Terms for Malignant Skin Fibrous Histiocytoma

Cellular components related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.7 CD99 CTLA4 F7 F9 HRAS ITGA2B
2 external side of plasma membrane GO:0009897 8.92 CTLA4 ITGA2B KIT NCAM1

Biological processes related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 IFNA2 IFNB1 KIT UBC
2 blood coagulation GO:0007596 9.71 F7 F9 IFNA2 IFNB1
3 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.7 HRAS NRAS UBC
4 natural killer cell activation involved in immune response GO:0002323 9.51 IFNA2 IFNB1
5 mast cell degranulation GO:0043303 9.48 CHGA KIT
6 peptidyl-glutamic acid carboxylation GO:0017187 9.46 F7 F9
7 negative regulation of T cell differentiation GO:0045581 9.43 IFNA2 IFNB1
8 blood coagulation, extrinsic pathway GO:0007598 9.37 F7 F9
9 ERBB2 signaling pathway GO:0038128 9.33 HRAS NRAS UBC
10 mast cell chemotaxis GO:0002551 9.32 CHGA KIT
11 negative regulation of T-helper 2 cell cytokine production GO:2000552 9.26 IFNA2 IFNB1
12 MAPK cascade GO:0000165 9.02 HRAS KIT NCAM1 NRAS UBC
13 mast cell cytokine production GO:0032762 8.96 CHGA KIT

Molecular functions related to Malignant Skin Fibrous Histiocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.83 CD99 CTLA4 F7 F9 HRAS IFNA2
2 type I interferon receptor binding GO:0005132 8.62 IFNA2 IFNB1

Sources for Malignant Skin Fibrous Histiocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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