Malignant Spindle Cell Melanoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Malignant Spindle Cell Melanoma

MalaCards integrated aliases for Malignant Spindle Cell Melanoma:

Name: Malignant Spindle Cell Melanoma ¹¹ ¹⁴

Spindle Cell Melanoma ¹¹ ¹⁶ ⁷¹

Desmoplastic Melanoma ¹¹ ⁷¹

Spindle Cell Malignant Melanoma ¹¹

Spitzoid Malignant Melanoma ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:3162

NCIt ⁴⁹ C4237

SNOMED-CT ⁶⁸ 68827007

EFO ¹⁶ EFO_1000546

UMLS ⁷¹ C0334444 C1333280

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Summaries for Malignant Spindle Cell Melanoma

Disease Ontology: ¹¹ A melanoma that is composed of spindled neoplastic cells arranged in sheets and fascicles.

MalaCards based summary: Malignant Spindle Cell Melanoma, also known as spindle cell melanoma, is related to fibrous histiocytoma and fibroma. An important gene associated with Malignant Spindle Cell Melanoma is MLANA (Melan-A), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Pembrolizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include lymph node, skin and spinal cord, and related phenotypes are Decreased viability and homeostasis/metabolism

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Related Diseases for Malignant Spindle Cell Melanoma

Diseases related to Malignant Spindle Cell Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 488)

#	Related Disease	Score	Top Affiliating Genes
1	fibrous histiocytoma	30.5	SOX10 SERPINA3 MLANA MITF CD34
2	fibroma	30.5	SERPINA3 NF1 CD34
3	melanocytic nevus syndrome, congenital	30.4	NRAS HRAS
4	neuroma	30.4	SERPINA3 NF1 KIT CD34
5	malignant choroid melanoma	30.4	MLANA GNAQ GNA11
6	angiosarcoma	30.3	SERPINA3 KIT CD34
7	clear cell sarcoma	30.3	TYR SOX10 MLANA MITF KIT
8	cutaneous leiomyosarcoma	30.2	MLANA KIT CD34
9	cutaneous fibrous histiocytoma	30.2	SOX10 SERPINA3 MLANA MITF CD34
10	rapidly involuting congenital hemangioma	30.1	GNAQ GNA11
11	sarcomatoid squamous cell skin carcinoma	30.1	SOX10 SERPINA3 MLANA CD34
12	neurofibromatosis-noonan syndrome	30.1	RASA2 NF1 HRAS
13	melanotic neurilemmoma	30.0	SOX10 MLANA GNAQ GNA11
14	malignant fibrous histiocytoma	29.9	TP53 SERPINA3 KIT
15	microphthalmia	29.9	TYR SOX10 PMEL MLANA MITF KIT
16	epithelioid cell melanoma	29.8	TYR NGFR MLANA MITF GNAQ GNA11
17	b-lymphoblastic leukemia/lymphoma	29.8	KIT CDKN2A CD34
18	dermatofibrosarcoma protuberans	29.7	TLE1 SOX10 SERPINA3 MLANA KIT CD34
19	amelanotic melanoma	29.7	TYR SOX10 SERPINA3 NRAS MLANA MITF
20	neurilemmoma	29.6	TYR SOX10 SERPINA3 NGFR NF1 MLANA
21	colorectal adenocarcinoma	29.6	TP53 HRAS CD274
22	mesenchymal cell neoplasm	29.5	TP53 SERPINA3 NF1 MLANA KIT CD34
23	malignant peripheral nerve sheath tumor	29.4	TP53 SOX10 NGFR NF1 MITF KIT
24	inherited cancer-predisposing syndrome	29.4	TP53 NF1 MITF KIT CDKN2A
25	bap1 tumor predisposition syndrome	29.4	TP53 NF1 MITF KIT CDKN2A
26	connective tissue benign neoplasm	29.3	TP53 SOX10 SERPINA3 NF1 MLANA KIT
27	malignant conjunctival melanoma	29.3	NRAS NF1 MLANA KIT HRAS GNAQ
28	spitzoid melanoma	29.3	PRAME NRAS MLANA HRAS GNAQ GNA11
29	mixed cell type cancer	29.3	TP53 SERPINA3 KIT HRAS CDKN2A
30	skin benign neoplasm	29.2	TYR TP53 SERPINA3 NF1 MLANA HRAS
31	leiomyosarcoma	29.1	TP53 SERPINA3 NF1 MLANA KIT CDKN2A
32	neurofibromatosis	29.0	TP53 RASA2 NRAS NF1 KIT HRAS
33	skin melanoma	28.8	TYR TP53 NRAS MLANA MITF KIT
34	leukemia, chronic lymphocytic	28.7	TP53 NRAS KIT HRAS CDKN2A CD34
35	neurofibroma	28.6	TYR TP53 SOX10 RASA2 NGFR NF1
36	neurofibromatosis, type i	28.5	TP53 RASA2 NRAS NGFR NF1 KIT
37	melanoma	28.4	TYR TP53 SOX10 PRAME PMEL NRAS
38	melanoma in congenital melanocytic nevus	28.3	TYR TP53 SOX10 PMEL NRAS NGFR
39	myxofibrosarcoma	28.0	TP53 TLE1 SOX10 SERPINA3 NF1 KIT
40	mucosal melanoma	28.0	TYR SOX10 PMEL NRAS NF1 MLANA
41	peripheral nervous system disease	27.9	TP53 SOX10 SERPINA3 NRAS NGFR NF1
42	melanoma, cutaneous malignant 1	27.8	TYR TP53 SOX10 PMEL NRAS NF1
43	nodular malignant melanoma	27.7	TYR TP53 SOX10 PMEL NRAS NF1
44	choroid spindle cell melanoma	11.6
45	ciliary body spindle cell melanoma	11.5
46	iris spindle cell melanoma	11.4
47	spindle cell intraocular melanoma	11.3
48	conjunctival pigmentation	10.4	SOX10 MLANA
49	ciliary body cancer	10.4	TYR MLANA
50	ureter leiomyoma	10.4	MLANA KIT

Graphical network of the top 20 diseases related to Malignant Spindle Cell Melanoma:

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Symptoms & Phenotypes for Malignant Spindle Cell Melanoma

GenomeRNAi Phenotypes related to Malignant Spindle Cell Melanoma according to GeneCards Suite gene sharing:

²⁵ (show all 11)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.2	CD274 CD34 CDKN2A GNA11 GNAQ HRAS
2	no effect	GR00402-S-2	10.2	CD274 CD34 CDKN2A GNA11 GNAQ HRAS
3	Decreased viability	GR00055-A-1	9.89	HRAS
4	Decreased viability	GR00055-A-2	9.89	HRAS
5	Decreased viability	GR00221-A-1	9.89	CDKN2A HRAS KIT NF1 NRAS
6	Decreased viability	GR00221-A-2	9.89	HRAS NF1
7	Decreased viability	GR00221-A-3	9.89	CDKN2A HRAS NRAS
8	Decreased viability	GR00221-A-4	9.89	CDKN2A NF1
9	Decreased viability	GR00249-S	9.89	NF1
10	Decreased viability	GR00301-A	9.89	KIT
11	Decreased viability	GR00386-A-1	9.89	NF1

MGI Mouse Phenotypes related to Malignant Spindle Cell Melanoma:

⁴⁵ (show all 21)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.43	CD274 CD34 CDKN2A GNA11 GNAQ HRAS
2	pigmentation	MP:0001186	10.38	CDKN2A GNA11 GNAQ KIT MITF MLANA
3	normal	MP:0002873	10.32	GNA11 GNAQ HRAS KIT MITF NF1
4	no phenotypic analysis	MP:0003012	10.32	CD274 CDKN2A HRAS KIT MITF MLANA
5	behavior/neurological	MP:0005386	10.28	CD274 CDKN2A GNA11 GNAQ HRAS KIT
6	endocrine/exocrine gland	MP:0005379	10.27	CDKN2A GNA11 GNAQ HRAS KIT MITF
7	neoplasm	MP:0002006	10.24	CD34 CDKN2A HRAS KIT NF1 NRAS
8	limbs/digits/tail	MP:0005371	10.24	GNA11 GNAQ KIT MITF NF1 NGFR
9	renal/urinary system	MP:0005367	10.22	GNA11 GNAQ HRAS KIT MITF NF1
10	cellular	MP:0005384	10.21	CD274 CD34 CDKN2A KIT MITF NF1
11	immune system	MP:0005387	10.18	CD274 CD34 CDKN2A GNA11 GNAQ KIT
12	muscle	MP:0005369	10.16	CDKN2A GNA11 GNAQ HRAS KIT NF1
13	craniofacial	MP:0005382	10.16	GNA11 GNAQ HRAS KIT MITF NF1
14	liver/biliary system	MP:0005370	10.15	CDKN2A GNA11 KIT MITF NF1 NGFR
15	hearing/vestibular/ear	MP:0005377	10.11	GNA11 GNAQ KIT MITF NF1 NGFR
16	digestive/alimentary	MP:0005381	10.08	CDKN2A HRAS KIT NF1 NGFR NRAS
17	skeleton	MP:0005390	10.03	CD274 CDKN2A GNA11 GNAQ HRAS KIT
18	respiratory system	MP:0005388	9.97	CDKN2A GNA11 GNAQ HRAS KIT NF1
19	hematopoietic system	MP:0005397	9.97	CD274 CD34 CDKN2A GNA11 GNAQ KIT
20	mortality/aging	MP:0010768	9.8	CD274 CDKN2A GNA11 GNAQ HRAS KIT
21	integument	MP:0010771	9.55	CD274 CD34 CDKN2A GNA11 GNAQ HRAS

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Drugs & Therapeutics for Malignant Spindle Cell Melanoma

Drugs for Malignant Spindle Cell Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Pembrolizumab

Approved

Phase 2

1374853-91-4

254741536

2

Antineoplastic Agents, Immunological

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase II Trial Evaluating Resection Followed By Adjuvant Radiation Therapy (RT) For Patients With Desmoplastic Melanoma	Completed	NCT00060333	Phase 2
2	A Phase II and Pilot Trial of PD-1 Blockade With Pembrolizumab (MK-3475) in Patients With Resectable or Unresectable Desmoplastic Melanoma (DM)	Active, not recruiting	NCT02775851	Phase 2

Search NIH Clinical Center for Malignant Spindle Cell Melanoma

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Genetic Tests for Malignant Spindle Cell Melanoma

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Anatomical Context for Malignant Spindle Cell Melanoma

Organs/tissues related to Malignant Spindle Cell Melanoma:

MalaCards : Lymph Node, Skin, Spinal Cord, Breast, Cervix, Testis, Lung

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Publications for Malignant Spindle Cell Melanoma

Articles related to Malignant Spindle Cell Melanoma:

(show top 50) (show all 512)

#	Title	Authors	PMID	Year
1	PRAME expression in spindle cell melanoma, malignant peripheral nerve sheath tumour, and other cutaneous sarcomatoid neoplasms: a comparative analysis. ⁶²	Hrycaj SM...Chan MP	36102613	2022
2	Diagnostic utility of PRAME, p53 and 5-hmC immunostaining for distinguishing melanomas from naevi, neurofibromas, scars and other histological mimics. ⁶²	Rawson RV...Wilmott JS	35987723	2022
3	Desmoplastic melanoma treated with wide local excision or Mohs micrographic surgery: Rates of positive margins, local recurrence, and repeat surgeries. ⁶²	Ran NA...Miller CJ	35963290	2022
4	Sentinel lymph node biopsy in desmoplastic melanoma - the percent desmoplastic component matters: A systematic review. ⁶²	Hodson M...Davis L	36283925	2022
5	Current and future approaches in the surgical management of T3b/T4 primary and locoregionally advanced melanoma. ⁶²	Sondak VK...Khushalani NI	36066835	2022
6	Stage II desmoplastic melanoma treated with neoadjuvant immunotherapy and Mohs micrographic surgery. ⁶²	Lewis DJ...Cohen JV	36271491	2022
7	PRAME Immunoexpression in 275 Cutaneous Melanocytic Lesions: A Double Institutional Experience. ⁶²	Cazzato G...Resta L	36140597	2022
8	PRAME expression is similar in scar and desmoplastic melanoma. ⁶²	Plotzke JM...Chan MP	35752877	2022
9	From Morphea to Dermatofibrosarcoma Protuberans. ⁶²	Crnaric I...Buljan M	36254545	2022
10	Nasal Mucosal Desmoplastic Melanoma: A Case Report with Review of the Literature. ⁶²	Ortega CA...Topf MC	35257324	2022
11	Does the morphology of cutaneous melanoma help to explain the international differences in survival? Results from 1 578 482 adults diagnosed during 2000-2014 in 59 countries (CONCORD-3). ⁶²	Di Carlo V...CONCORD Working Group	35347700	2022
12	Pure and Mixed Desmoplastic Melanoma Subtypes Exhibit Distinct Genetic Drivers. ⁶²	Mahalingam M	34999597	2022
13	An Unusual Case of Desmoplastic Melanoma With Monster Cells Imitating an Atypical Fibroxanthoma. ⁶²	Rios-Martin JJ...Vallejo-Benitez A	34541940	2022
14	Clinical challenge - scratching the surface of the sheath. ⁶²	Sheng J...Falardeau J	33610587	2022
15	Evolution of superficial spreading melanoma to resemble desmoplastic melanoma: case report. ⁶²	Cook MG...Green AC	34286349	2022
16	Sarcomatoid Dedifferentiated Melanoma: The Diagnostic Role of Next-Generation Sequencing. ⁶²	Valiga AA...Lee JB	34726188	2022
17	Spindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates. ⁶²	Boyraz B...Hung YP	34942046	2022
18	The changing landscape in management of desmoplastic melanoma. ⁶²	Dunne JA...Adigbli G	34535908	2022
19	Update on the Diagnosis and Management of Desmoplastic Melanoma. ⁶²	Boada Garcia A...Jaka-Moreno A	35249710	2022
20	Acute appendicitis secondary to desmoplastic melanoma metastasis in immune-checkpoint inhibitors era. ⁶²	Avallone G...Ribero S	34456328	2021
21	Atypical Fibroxanthoma Demonstrating HMB45+ Staining. ⁶²	Sahni VN...Cassarino DS	34132658	2021
22	Primary Alopecia Neoplastica: A Novel Case Report and Literature Review. ⁶²	Flanagan KE...Senna MM	34901185	2021
23	Comparison of Survival Outcomes With/Without Adjuvant Radiation Therapy in Desmoplastic Melanoma. ⁶²	Lewis GD...Teh BS	34537788	2021
24	Evolving treatments and future therapeutic targets in desmoplastic melanoma. ⁶²	Hadfield MJ...Grant-Kels JM	34900219	2021
25	PDGFB RNA in situ hybridization for the diagnosis of dermatofibrosarcoma protuberans. ⁶²	Cloutier JM...Charville GW	33762682	2021
26	Melanoma genomics: a state-of-the-art review of practical clinical applications. ⁶²	Guhan S...Tsao H	34096042	2021
27	Evolution of a melanoma in situ to a sarcomatoid dedifferentiated melanoma. ⁶²	Chung J...Lee JB	33675557	2021
28	Dermatoscopy of melanoma according to type, anatomic site and stage. ⁶²	Lallas A...Apalla Z	33314891	2021
29	Desmoplastic melanoma: a review of its pathology and clinical behaviour, and of management recommendations in published guidelines. ⁶²	Hughes TM...Thompson JF	33544941	2021
30	Metastatic Melanoma With Features of Desmoplastic Melanoma in a Patient With Primary Cutaneous Superficial Spreading Melanoma With Epithelioid Features. ⁶²	Modi MB...Xu X	33464752	2021
31	Unusual presentation of a choroidal melanoma. ⁶²	Jain S...Phoong KY	34045197	2021
32	Uveal Melanoma and Secondary Angle-Closure Crisis: A Case Report and Literature Review. ⁶²	Hoang TT...Grigg J	34177544	2021
33	Desmoplastic Melanoma Masquerading as Neurofibroma. ⁶²	Stokar E...Feldman J	34288854	2021
34	An eyebrow lump: malignant spindle cell melanoma. ⁶²	Hoang TT...Sullivan TJ	33728636	2021
35	Primary Cutaneous Desmoplastic Melanoma With Collagen Rosettes and Pseudoglandular Features. ⁶²	Donati M...Kazakov DV	33201013	2021
36	Local Recurrence Rates of Skin Tumors After Resection With Complete Circumferential Peripheral and Deep Margin Assessment-Identification of High-Risk Entities. ⁶²	Kofler L...Kofler K	33565775	2021
37	LMNA-NTRK1 rearranged mesenchymal tumor (lipofibromatosis-like neural tumor) mimicking pigmented dermatofibrosarcoma protuberans. ⁶²	Panse G...Jour G	32519338	2021
38	Re-evaluation of Sentinel Lymph Node Biopsy for Melanoma. ⁶²	Morrison S...Han D	33560505	2021
39	Desmoplastic Melanoma: A Clinicopathological Analysis of Three Cases in the Chinese Population. ⁶²	Fan Y...Liu Y	33883908	2021
40	Cutaneous Desmoplastic Leiomyosarcoma Development at Smallpox Vaccination Site. ⁶²	Patel MH...Luber AJ	35022120	2021
41	Unusual Mesenchymal Tumors of the Lower Gastrointestinal Tract: When You Hear Hoofbeats in the Night, Do Not Forget the Zebras. ⁶²	Barella M...Del Gobbo A	34814148	2021
42	Diagnosis and Management of Melanoma of the Scalp: A Review of the Literature. ⁶²	Licata G...Moscarella E	34675579	2021
43	Extensive Perineural Spread of Subungual Melanoma. ⁶²	Murthy NK...Spinner RJ	32916345	2021
44	Impact of Therapy & Age in Choroidal Cancers: A Retrospective Cohort Analysis of 7722 Patients from a US National Database. ⁶²	Hussain Z...Ali S	33953535	2021
45	Pitfalls in the diagnosis of lentigo maligna and lentigo maligna melanoma, facts and an opinion. ⁶²	Sina N...Ghazarian D	33051287	2021
46	Lentigo maligna melanoma in situ with neurotropism. ⁶²	Occidental M...Jour G	32557727	2020
47	Desmoplastic Melanomas Mimicking Neurofibromas. ⁶²	Gerami P...Busam K	32732692	2020
48	Spindle cell melanoma coexisting with chronic lymphocytic leukemia/small lymphocytic lymphoma: a rare collision tumor in multiple sites. ⁶²	Dirilenoglu F...Mocan G	32959377	2020
49	The Histogenetic Model of Melanoma in the Modern Era of Personalized Medicine. ⁶²	Roncati L...Piscioli F	33834997	2020
50	Spindle-cell malignant melanoma. ⁶²	Company-Quiroga J...Martinez-Moran C	31249216	2020

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Genes for Malignant Spindle Cell Melanoma

Genes related to Malignant Spindle Cell Melanoma (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MLANA	Melan-A	Protein Coding	7.92	DISEASES inferred ¹⁴
2	SERPINA3	Serpin Family A Member 3	Protein Coding	7.73	DISEASES inferred ¹⁴ ¹⁴
3	SOX10	SRY-Box Transcription Factor 10	Protein Coding	7.1	DISEASES inferred ¹⁴
4	MITF	Melanocyte Inducing Transcription Factor	Protein Coding	7.06	DISEASES inferred ¹⁴
5	TYR	Tyrosinase	Protein Coding	6.58	DISEASES inferred ¹⁴
6	NF1	Neurofibromin 1	Protein Coding	6.54	DISEASES inferred ¹⁴
7	NRAS	NRAS Proto-Oncogene, GTPase	Protein Coding	6.46	DISEASES inferred ¹⁴
8	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	6.22	DISEASES inferred ¹⁴
9	PMEL	Premelanosome Protein	Protein Coding	6.07	DISEASES inferred ¹⁴
10	GNAQ	G Protein Subunit Alpha Q	Protein Coding	5.99	DISEASES inferred ¹⁴
11	PRAME	PRAME Nuclear Receptor Transcriptional Regulator	Protein Coding	5.97	DISEASES inferred ¹⁴
12	CD34	CD34 Molecule	Protein Coding	5.96	DISEASES inferred ¹⁴
13	GNA11	G Protein Subunit Alpha 11	Protein Coding	5.88	DISEASES inferred ¹⁴
14	NGFR	Nerve Growth Factor Receptor	Protein Coding	5.88	DISEASES inferred ¹⁴
15	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	5.76	DISEASES inferred ¹⁴
16	CD274	CD274 Molecule	Protein Coding	5.74	DISEASES inferred ¹⁴
17	RASA2	RAS P21 Protein Activator 2	Protein Coding	5.56	DISEASES inferred ¹⁴
18	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	5.54	DISEASES inferred ¹⁴
19	TLE1	TLE Family Member 1, Transcriptional Corepressor	Protein Coding	5.43	DISEASES inferred ¹⁴
20	TP53	Tumor Protein P53	Protein Coding	5.26	DISEASES inferred ¹⁴

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Variations for Malignant Spindle Cell Melanoma

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Expression for Malignant Spindle Cell Melanoma

Search GEO for disease gene expression data for Malignant Spindle Cell Melanoma.

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Pathways for Malignant Spindle Cell Melanoma

Pathways related to Malignant Spindle Cell Melanoma according to GeneCards Suite gene sharing:

(show all 32)

#	Super pathways	Score	Top Affiliating Genes
1	ERK Signaling ⁶⁴ Show member pathways ILK Signaling ⁶⁴ MAPK Signaling ⁶⁴ Molecular Mechanisms of Cancer ⁶⁴ Rho Family GTPases ⁶⁴	13.74	TP53 SOX10 NRAS NGFR NF1 KIT
2	Signal Transduction ⁶⁶	13.59	CD274 GNA11 GNAQ HRAS KIT NF1
3	Prolactin Signaling ⁶⁴ Show member pathways Development Prolactin receptor signaling ²² EGFR Inhibitor Pathway, Pharmacodynamics ⁶⁰ EGFR tyrosine kinase inhibitor resistance ⁷⁴ ErbB Family Pathway ⁶⁴ ErbB signaling pathway ⁷⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Estrogen-stimulated signaling through PRKCZ ⁶⁶ Glioblastoma Multiforme ⁶⁴ Glioblastoma signaling pathways ⁷⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-2 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ TCA cycle nutrient use and invasiveness of ovarian cancer ⁷⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVA-Induced MAPK Signaling ⁶⁴ UVB-Induced MAPK Signaling ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.37	TP53 RASA2 NRAS NF1 HRAS GNAQ
4	Phospholipase-C Pathway ⁶⁴ Show member pathways PTEN Pathway ⁶⁴	12.98	GNA11 HRAS KIT NGFR NRAS TP53
5	TNFR1 Pathway ⁶⁴ Show member pathways Apoptosis ⁷⁴ Apoptosis and survival TNFR1 signaling pathway ²² Apoptosis modulation by HSP70 ⁷⁴ Apoptosis through Death Receptors ⁶⁴ Apoptotic Pathways Triggered By HIV1 ⁶⁴ Ceramide signaling pathway ⁶¹ DR3 Signaling ⁶⁴ GITR Pathway ⁶⁴ HIV-1 Nef: Negative effector of Fas and TNF-alpha ⁶¹ Stimulation of the cell death response by PAK-2p34 ⁶⁶ TNF Signaling ⁶⁴ TNF-related weak inducer of apoptosis (TWEAK) signaling pathway ⁷⁴ TRAIL Pathway ⁶⁴ TWEAK Pathway ⁶⁴	12.81	TP53 NGFR HRAS GNAQ GNA11 CDKN2A
6	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.73	NRAS KIT HRAS GNAQ GNA11
7	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.56	TP53 NRAS NGFR KIT HRAS
8	Malignant pleural mesothelioma ⁷⁴	12.55	TP53 NGFR KIT HRAS CDKN2A CD274
9	NF-kappaB Signaling ³	12.45	PRAME MLANA KIT CD34 CD274
10	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.42	CDKN2A HRAS KIT MITF NF1 NRAS
11	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.37	TP53 NRAS KIT HRAS
12	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.35	TP53 NRAS NGFR HRAS
13	MAPK signaling pathway ⁷⁴	12.28	TP53 RASA2 NRAS NF1 HRAS
14	NGF Pathway ⁶⁴ Show member pathways MAPK and NFkB signaling pathways inhibited by Yersinia YopJ ⁷⁴ TRKA Signaling ⁶⁴	12.06	TP53 NRAS NGFR HRAS
15	MAP Kinase Signaling ³	11.88	NRAS NF1 HRAS GNAQ
16	Gastrin signaling pathway ⁷⁴	11.86	KIT HRAS GNAQ CDKN2A
17	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.8	NGFR KIT CD34
18	VEGF Pathway (Tocris) ⁷⁰ Show member pathways Sorafenib Pharmacodynamics ⁶⁰	11.71	NRAS KIT HRAS
19	mTOR Pathway ⁷⁰ Show member pathways TGF-beta Pathway ⁷⁰	11.7	TP53 NRAS HRAS
20	Ras signaling ⁷⁴	11.7	RASA2 NRAS NGFR NF1 KIT HRAS
21	C-MYB transcription factor network ⁶¹	11.68	NRAS KIT CDKN2A CD34
22	Regulation of nuclear beta catenin signaling and target gene transcription ⁶¹	11.66	TLE1 MITF CDKN2A
23	Serotonin HTR1 group and FOS pathway ⁷⁴ Show member pathways Serotonin receptor 2 and ELK-SRF/GATA4 signaling ⁷⁴ Serotonin receptor 4/6/7 and NR3C signaling ⁷⁴	11.57	NRAS HRAS GNAQ
24	Head and neck squamous cell carcinoma ⁷⁴	11.57	TP53 NRAS HRAS CDKN2A
25	Prader-Willi and Angelman syndrome ⁷⁴	11.55	TYR TP53 CDKN2A
26	BDNF-TrkB signaling ⁷⁴ Show member pathways Synaptic signaling pathways associated with autism spectrum disorder ⁷⁴	11.55	NRAS NF1 HRAS
27	Melanocyte Development and Pigmentation ⁶⁴	11.34	KIT MITF SOX10
28	Bladder cancer ⁷⁴	11.27	TP53 NRAS HRAS CDKN2A
29	Transcription_Transcription factor Tubby signaling pathways ²²	11.13	TP53 NRAS HRAS GNAQ GNA11
30	Regulation of Ras family activation ⁶¹ Show member pathways Activation of RAS in B cells ⁶⁶	10.96	RASA2 NRAS NF1 HRAS
31	TNF-alpha signaling pathway ⁷⁴ Show member pathways RAS GTPase cycle mutants ⁶⁶ Signaling by RAS GAP mutants ⁶⁶ Signaling by RAS GTPase mutants ⁶⁶	10.73	NRAS HRAS
32	GPR143 in melanocytes and retinal pigment epithelium cells ⁷⁴	10.47	TYR PMEL MLANA MITF GNAQ

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GO Terms for Malignant Spindle Cell Melanoma

Biological processes related to Malignant Spindle Cell Melanoma according to GeneCards Suite gene sharing:

(show all 11)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.32	TLE1 RASA2 NRAS NGFR NF1 KIT
2	neuron apoptotic process	GO:0051402	10.01	HRAS NF1 NGFR TP53
3	positive regulation of gene expression	GO:0010628	9.97	CD34 CDKN2A HRAS KIT MITF SOX10
4	neuroblast proliferation	GO:0007405	9.95	TP53 SOX10 NF1
5	regulation of cell population proliferation	GO:0042127	9.92	HRAS KIT MITF NF1 TP53
6	melanocyte differentiation	GO:0030318	9.91	SOX10 MITF KIT
7	fibroblast proliferation	GO:0048144	9.86	TP53 NGFR NF1 HRAS
8	entrainment of circadian clock	GO:0009649	9.8	GNAQ GNA11
9	mast cell proliferation	GO:0070662	9.76	NF1 KIT
10	Ras protein signal transduction	GO:0007265	9.65	TP53 NRAS NF1 HRAS CDKN2A
11	pigmentation	GO:0043473	9.17	TYR NF1 MITF KIT

Sources

Sources for Malignant Spindle Cell Melanoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: MLG005 MIFTS: 41	Malignant Spindle Cell Melanoma Categories: Cancer diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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