MCID: MLG005
MIFTS: 40

Malignant Spindle Cell Melanoma

Categories: Cancer diseases, Skin diseases

Aliases & Classifications for Malignant Spindle Cell Melanoma

MalaCards integrated aliases for Malignant Spindle Cell Melanoma:

Name: Malignant Spindle Cell Melanoma 12 15
Spindle Cell Melanoma 12 17 71
Desmoplastic Melanoma 12 71
Spindle Cell Malignant Melanoma 12
Spitzoid Malignant Melanoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3162
NCIt 49 C4237
SNOMED-CT 67 68827007
UMLS 71 C0334444 C1333280

Summaries for Malignant Spindle Cell Melanoma

Disease Ontology : 12 A melanoma that is composed of spindled neoplastic cells arranged in sheets and fascicles.

MalaCards based summary : Malignant Spindle Cell Melanoma, also known as spindle cell melanoma, is related to lentigo maligna melanoma and malignant choroid melanoma. An important gene associated with Malignant Spindle Cell Melanoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are TNFR1 Pathway and Beta-Adrenergic Signaling. The drugs Pembrolizumab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Malignant Spindle Cell Melanoma

Diseases related to Malignant Spindle Cell Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 284)
# Related Disease Score Top Affiliating Genes
1 lentigo maligna melanoma 30.7 MLANA MITF
2 malignant choroid melanoma 30.6 SOX10 MLANA MITF
3 dowling-degos disease 1 30.6 TYR MITF KIT
4 dermatofibrosarcoma protuberans 30.5 SERPINA3 KIT CD34
5 leiomyosarcoma 30.4 SERPINA3 NF1 MLANA KIT
6 sarcomatoid squamous cell skin carcinoma 30.4 SERPINA3 MLANA FOXO4 CD34
7 clear cell sarcoma 30.4 SOX10 MLANA MITF KIT
8 pyogenic granuloma 30.3 NRAS CD34
9 neurofibromatosis, type i 30.2 RASA2 NF1 KIT
10 melanotic neurilemmoma 30.1 MLANA GNAQ CD34
11 microphthalmia 30.0 TYR SOX10 PMEL MLANA MITF KIT
12 epithelioid cell melanoma 29.9 TYR NGFR MLANA MITF GNAQ
13 neurofibromatosis, type iv, of riccardi 29.9 RASA2 NF1 KIT HRAS
14 amelanotic melanoma 29.9 TYR SERPINA3 MLANA MITF KIT
15 malignant conjunctival melanoma 29.8 NRAS MLANA GNAQ GNA11
16 neuroma 29.7 SERPINA3 NF1 CD68 CD34
17 fibroma 29.7 SERPINA3 CD68 CD34
18 malignant peripheral nerve sheath tumor 29.7 SOX10 NGFR NF1 MLANA MITF KIT
19 melanoma 29.5 TYR PMEL NRAS MLANA MITF KIT
20 fibrous histiocytoma 29.5 SERPINA3 MITF CD68 CD34
21 malignant fibroxanthoma 29.4 SERPINA3 FOXO4 CD68 CD34
22 neurilemmoma 29.2 TYR SOX10 SERPINA3 NGFR NF1 MITF
23 histiocytoma 29.1 SERPINA3 MITF KIT CD68 CD34
24 skin melanoma 29.1 TYR PMEL NRAS MLANA MITF HRAS
25 neurofibroma 29.0 TYR SOX10 RASA2 NGFR NF1 MLANA
26 cutaneous fibrous histiocytoma 29.0 SERPINA3 MLANA MITF FOXO4 CD68 CD34
27 mucosal melanoma 28.8 NRAS NGFR NF1 MITF KIT GNAQ
28 mesenchymal cell neoplasm 28.8 SERPINA3 NF1 MLANA KIT CD68 CD34
29 choroid spindle cell melanoma 12.5
30 ciliary body spindle cell melanoma 12.5
31 iris spindle cell melanoma 12.5
32 spindle cell intraocular melanoma 11.4
33 waardenburg syndrome type 4 10.6 SOX10 MITF
34 uterus perivascular epithelioid cell tumor 10.5 MLANA MITF
35 lateral displacement of eye 10.5 SOX10 MITF
36 waardenburg syndrome, type 2b 10.5 SOX10 MITF
37 malignant ciliary body melanoma 10.5 TYR MLANA
38 ciliary body cancer 10.5 TYR MLANA
39 cellular neurofibroma 10.5 SOX10 NF1
40 melanoacanthoma 10.5 TYR MLANA
41 peripheral nerve schwannoma 10.5 SERPINA3 NF1
42 diffuse meningeal melanocytosis 10.5 TYR MLANA
43 selection of therapeutic option in melanoma 10.5 NRAS KIT
44 pigmented basal cell carcinoma 10.5 MLANA MITF
45 vagina leiomyosarcoma 10.5 MLANA KIT
46 cutaneous solitary mastocytoma 10.5 SERPINA3 KIT
47 penis sarcoma 10.5 MLANA CD34
48 type c thymoma 10.5 SERPINA3 KIT
49 waardenburg syndrome, type 4c 10.4 SOX10 MITF
50 glomangiosarcoma 10.4 MLANA CD34

Graphical network of the top 20 diseases related to Malignant Spindle Cell Melanoma:



Diseases related to Malignant Spindle Cell Melanoma

Symptoms & Phenotypes for Malignant Spindle Cell Melanoma

GenomeRNAi Phenotypes related to Malignant Spindle Cell Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.6 HRAS
2 Decreased viability GR00221-A-1 9.6 FOXO4 HRAS KIT NF1 NRAS
3 Decreased viability GR00221-A-2 9.6 FOXO4 HRAS NF1
4 Decreased viability GR00221-A-3 9.6 HRAS NRAS
5 Decreased viability GR00221-A-4 9.6 FOXO4 NF1
6 Decreased viability GR00301-A 9.6 KIT
7 Decreased viability GR00402-S-2 9.6 FOXO4 HRAS KIT NF1 NRAS

MGI Mouse Phenotypes related to Malignant Spindle Cell Melanoma:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.32 CD34 CD68 FOXO4 GNA11 GNAQ KIT
2 homeostasis/metabolism MP:0005376 10.31 CD34 FOXO4 GNA11 GNAQ HRAS KIT
3 behavior/neurological MP:0005386 10.3 GNA11 GNAQ HRAS KIT MITF NF1
4 immune system MP:0005387 10.29 CD34 CD68 FOXO4 GNA11 GNAQ KIT
5 integument MP:0010771 10.27 CD34 GNA11 GNAQ HRAS KIT MITF
6 endocrine/exocrine gland MP:0005379 10.24 FOXO4 GNA11 GNAQ HRAS KIT MITF
7 craniofacial MP:0005382 10.2 GNA11 GNAQ HRAS KIT MITF NF1
8 limbs/digits/tail MP:0005371 10.09 GNA11 GNAQ KIT MITF NF1 NGFR
9 hearing/vestibular/ear MP:0005377 10.07 GNA11 GNAQ KIT MITF NF1 NGFR
10 normal MP:0002873 10.06 FOXO4 GNA11 GNAQ HRAS KIT MITF
11 no phenotypic analysis MP:0003012 10.02 CD68 HRAS KIT MITF MLANA NRAS
12 neoplasm MP:0002006 10.01 CD34 FOXO4 HRAS KIT NF1 NRAS
13 pigmentation MP:0001186 9.96 GNA11 GNAQ KIT MITF MLANA NF1
14 renal/urinary system MP:0005367 9.76 GNA11 GNAQ HRAS KIT MITF NF1
15 respiratory system MP:0005388 9.5 GNA11 GNAQ HRAS KIT NF1 NGFR
16 skeleton MP:0005390 9.36 CD68 GNA11 GNAQ HRAS KIT MITF

Drugs & Therapeutics for Malignant Spindle Cell Melanoma

Drugs for Malignant Spindle Cell Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2 Antineoplastic Agents, Immunological Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Trial Evaluating Resection Followed By Adjuvant Radiation Therapy (RT) For Patients With Desmoplastic Melanoma Completed NCT00060333 Phase 2
2 A Phase II and Pilot Trial of PD-1 Blockade With MK-3475 (Pembrolizumab) in Patients With Resectable or Unresectable Desmoplastic Melanoma (DM) Recruiting NCT02775851 Phase 2
3 A Randomised Trial of Post-operative Radiation Therapy Following Wide Excision of Neurotropic Melanoma of the Head and Neck Recruiting NCT00975520

Search NIH Clinical Center for Malignant Spindle Cell Melanoma

Genetic Tests for Malignant Spindle Cell Melanoma

Anatomical Context for Malignant Spindle Cell Melanoma

MalaCards organs/tissues related to Malignant Spindle Cell Melanoma:

40
Skin, Breast, Liver, Myeloid, Small Intestine, Eye, Spleen

Publications for Malignant Spindle Cell Melanoma

Articles related to Malignant Spindle Cell Melanoma:

(show top 50) (show all 112)
# Title Authors PMID Year
1
Spindle cell melanoma arising in a burn scar: An unusual presentation with dermatoscopic findings. 61
31613413 2019
2
Oral Melanomas: A Case Series of a Deadly Neoplasm. 61
30998880 2019
3
Sarcomatoid Carcinoma With Quasi-Complete Loss of Cytokeratin Expression or Keratin-Positive Atypical Fibroxanthoma. 61
30760056 2019
4
Tapioca Melanoma of the Iris: A Case Report. 61
31660116 2019
5
Choroidal Melanoma: Our Experience. 61
31523069 2019
6
Spindle cell melanoma: Incidence and survival, 1973-2017. 61
30250577 2018
7
Desmoplastic melanoma versus spindle cell melanoma: Incidence and survival, 1973 to 2017. 61
30024556 2018
8
Rare Occurrence of an Intraocular Choroidal Solitary Fibrous Tumor/Hemangiopericytoma. 61
30643764 2018
9
Osteogenic melanoma: report of a case mimicking osteosarcoma and review of the literature. 61
29196822 2018
10
Mixed Versus Pure Variants of Desmoplastic Melanoma: The Cleveland Clinic Experience. 61
28984655 2018
11
Primary cutaneous interdigitating dendritic cell sarcoma is a morphologic and phenotypic simulator of poorly differentiated metastatic melanoma: A report of 2 cases and review of the literature. 61
28302385 2017
12
Lower Extremity Desmoplastic Malignant Melanoma in Egypt. 61
28979029 2017
13
Primary oral malignant melanoma metastasis to the brain and breast: A case report and literature review. 61
28789341 2017
14
Performance Testing of RREB1, MYB, and CCND1 Fluorescence In Situ Hybridization in Spindle-Cell and Desmoplastic Melanoma Argues for a Two-Step Test Algorithm. 61
27899693 2017
15
Ovarian metastasis from uveal melanoma with MLH1/PMS2 protein loss in a patient with germline MLH1 mutated Lynch syndrome: consequence or coincidence? 61
27915441 2017
16
Superficial malignant peripheral nerve sheath tumor with overlying intradermal melanocytic nevus mimicking spindle cell melanoma. 61
27687011 2016
17
Spindle Cell Melanoma and Interdigitating Dendritic Cell Sarcoma: Do They Represent the Same Process? 61
27299798 2016
18
Head and Neck Extranodal Interdigitating Dendritic Cell Sarcoma: Case Report and Review of the Literature. 61
25893828 2016
19
Lipomatous Change in Uveal Melanoma: Histopathological, Immunohistochemical and Cytogenetic Analysis. 61
27239451 2016
20
Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. 61
26585554 2016
21
[Immunohistochemical and genetic profiles of melanomas with spindle cell morphology]. 61
26485776 2015
22
MelanA-negative spindle-cell associated melanoma, a distinct inflammatory phenotype correlated with dense infiltration of CD163 macrophages and loss of E-cadherin. 61
25602697 2015
23
Cytologic features of pigmented atypical meningioma mimicking melanoma on intraoperative crush preparations. 61
24692367 2015
24
An unusual case of desmoplastic malignant melanoma. 61
25949027 2015
25
Comment on 'A diagnostic algorithm to distinguish desmoplastic from spindle cell melanoma'. 61
25269807 2014
26
S100A6 and c-Kit-Positive Spindle Cell Melanoma of the Dorsal Foot. 61
24932168 2014
27
A diagnostic algorithm to distinguish desmoplastic from spindle cell melanoma. 61
24051699 2014
28
Growth-associated protein 43 in differentiating peripheral nerve sheath tumors from other non-neural spindle cell neoplasms. 61
23887302 2014
29
Desmoplastic melanoma--challenges in the diagnosis and management of a rare cutaneous tumor. 61
25329125 2014
30
A nuclear circularity-based classifier for diagnostic distinction of desmoplastic from spindle cell melanoma in digitized histological images. 61
25379346 2014
31
Neurofibroma with numerous lymphoid aggregates simulating spindle cell melanoma: utilization of CD34 fingerprint for diagnosis. 61
23812017 2013
32
Desmoplastic melanoma: a review. 61
23267722 2013
33
Superficial paramucosal clear cell sarcoma of the soft parts resembling melanoma in a 13-year-old boy. 61
23228147 2013
34
Spindle cell melanoma: a comparison of the cytomorphological features with the epithelioid variant. 61
24107480 2013
35
The role of sentinel lymph node biopsy in the management of head and neck desmoplastic melanoma. 61
22766985 2012
36
A histopathologic review of undiagnosed neoplasms in 205 evisceration specimens. 61
22965012 2012
37
BRAF, NRAS and KIT sequencing analysis of spindle cell melanoma. 61
22809251 2012
38
Cutaneous clear cell sarcoma: report of three cases of a potentially underestimated mimicker of spindle cell melanoma. 61
22421295 2012
39
Neurofibroma-like spindle cell melanoma: CD34 fingerprint and CGH for diagnosis. 61
22456515 2012
40
Role of CD10, wide-spectrum keratin, p63, and podoplanin in the distinction of epithelioid and spindle cell tumors of the skin: an immunohistochemical study of 81 cases. 61
22257901 2012
41
P75 nerve growth factor receptor as a useful marker to distinguish spindle cell melanoma from other spindle cell neoplasms of sun-damaged skin. 61
22207443 2012
42
Parotid gland solitary fibrous tumor: a case report and clinicopathologic review of 22 cases from the literature. 61
22002440 2012
43
p63 immunohistochemical staining is limited in soft tissue tumors. 61
22031315 2011
44
Diagnostic utility of low-affinity nerve growth factor receptor (P 75) immunostaining in atypical fibroxanthoma. 61
21623867 2011
45
Desmoplastic melanoma. 61
21549245 2011
46
Primary spindle cell melanoma of the urinary bladder. 61
21623121 2011
47
Sinonasal and nasopharyngeal applications of the hand-held CO2 laser fiber. 61
22287328 2011
48
Neoplasms with schwannian differentiation express transcription factors known to regulate normal schwann cell development. 61
20034979 2010
49
P75 nerve growth factor receptor staining is superior to S100 in identifying spindle cell and desmoplastic melanoma. 61
20950740 2010
50
Fine-needle aspiration cytology in a case of metastatic spindle cell melanoma in liver. 61
19894264 2010

Variations for Malignant Spindle Cell Melanoma

Expression for Malignant Spindle Cell Melanoma

Search GEO for disease gene expression data for Malignant Spindle Cell Melanoma.

Pathways for Malignant Spindle Cell Melanoma

Pathways related to Malignant Spindle Cell Melanoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.88 NRAS NGFR NFKBIE HRAS GNAQ GNA11
2
Show member pathways
12.73 NRAS NGFR NFKBIE HRAS GNA11
3
Show member pathways
12.73 NRAS KIT HRAS GNAQ GNA11
4 12.68 NRAS MITF KIT HRAS GNAQ GNA11
5
Show member pathways
12.63 NRAS NFKBIE KIT HRAS FOXO4
6
Show member pathways
12.58 NRAS NF1 MITF HRAS FOXO4
7 12.55 RASA2 NRAS NGFR NF1 KIT HRAS
8
Show member pathways
12.47 NGFR NFKBIE HRAS GNAQ GNA11
9
Show member pathways
12.47 TYR NRAS MITF KIT HRAS GNAQ
10
Show member pathways
12.41 NRAS HRAS GNAQ GNA11
11
Show member pathways
12.35 NRAS NFKBIE MITF HRAS
12
Show member pathways
12.25 NFKBIE HRAS GNAQ GNA11
13
Show member pathways
12.2 RASA2 NRAS NF1 HRAS
14
Show member pathways
11.96 NRAS HRAS GNAQ GNA11
15
Show member pathways
11.96 RASA2 NRAS NF1 HRAS
16
Show member pathways
11.93 RASA2 NRAS NF1 HRAS
17
Show member pathways
11.89 NFKBIE HRAS GNAQ GNA11
18
Show member pathways
11.87 RASA2 NRAS NGFR NF1 KIT HRAS
19 11.79 NRAS NF1 HRAS GNAQ
20
Show member pathways
11.74 NRAS KIT HRAS
21 11.71 NRAS KIT CD34
22 11.64 NRAS KIT HRAS
23 11.61 NRAS HRAS GNAQ GNA11
24 11.6 NRAS MITF HRAS
25 11.59 HRAS GNAQ GNA11
26 11.42 NRAS NF1 HRAS
27 11.36 NRAS HRAS GNAQ GNA11
28 11.34 SOX10 MITF KIT
29 11.11 NRAS HRAS FOXO4
30 11.03 NRAS HRAS GNAQ GNA11
31 10.8 NRAS HRAS GNAQ
32 10.76 NRAS HRAS

GO Terms for Malignant Spindle Cell Melanoma

Cellular components related to Malignant Spindle Cell Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.8 TYR PMEL MLANA

Biological processes related to Malignant Spindle Cell Melanoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.02 RASA2 NRAS NGFR NF1 KIT HRAS
2 positive regulation of gene expression GO:0010628 9.83 SOX10 MITF KIT HRAS CD34
3 MAPK cascade GO:0000165 9.65 RASA2 NRAS NF1 KIT HRAS
4 G protein-coupled acetylcholine receptor signaling pathway GO:0007213 9.54 GNAQ GNA11
5 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.52 GNAQ GNA11
6 melanin biosynthetic process GO:0042438 9.51 TYR PMEL
7 stem cell differentiation GO:0048863 9.5 SOX10 KIT FOXO4
8 positive regulation of phospholipase C activity GO:0010863 9.49 KIT HRAS
9 developmental pigmentation GO:0048066 9.48 KIT GNA11
10 phototransduction, visible light GO:0007603 9.46 GNAQ GNA11
11 entrainment of circadian clock GO:0009649 9.4 GNAQ GNA11
12 melanocyte differentiation GO:0030318 9.33 SOX10 MITF KIT
13 Ras protein signal transduction GO:0007265 9.26 RREB1 NRAS NF1 HRAS
14 pigmentation GO:0043473 8.92 TYR NF1 MITF KIT

Molecular functions related to Malignant Spindle Cell Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 type 2A serotonin receptor binding GO:0031826 8.62 GNAQ GNA11

Sources for Malignant Spindle Cell Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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