MES
MCID: MLG036
MIFTS: 29

Malignant Spiradenoma (MES)

Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Malignant Spiradenoma

MalaCards integrated aliases for Malignant Spiradenoma:

Name: Malignant Spiradenoma 11 14
Malignant Eccrine Spiradenoma 11 19 71
Eccrine Spiradenoma, Malignant 19
Mes 19

Classifications:



External Ids:

Disease Ontology 11 DOID:7960
NCIt 49 C5117
SNOMED-CT 68 403942003
UMLS 71 C1266063

Summaries for Malignant Spiradenoma

GARD: 19 Malignant eccrine spiradenoma is a type of tumor that develops from a sweat gland in the skin. It starts as a rapidly-growing bump on the head or abdomen, and may cause tenderness, redness, or an open wound. The exact cause of Malignant eccrine spiradenoma is unknown, though it is thought that sun exposure or problems with the immune system (immunosuppression) may contribute to the development of this tumor.

MalaCards based summary: Malignant Spiradenoma, also known as malignant eccrine spiradenoma, is related to adenoid cystic carcinoma and skin benign neoplasm. An important gene associated with Malignant Spiradenoma is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Ovarian tumor domain proteases and LKB1 signaling events. Affiliated tissues include skin, lymph node and smooth muscle, and related phenotype is digestive/alimentary.

Related Diseases for Malignant Spiradenoma

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Malignant Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 483)
# Related Disease Score Top Affiliating Genes
1 adenoid cystic carcinoma 29.9 TP53 KRT7 CYLD
2 skin benign neoplasm 29.6 TP53 PIP KRT7 KRT5 CYLD
3 colon adenocarcinoma 29.5 TP53 ESR1 CEACAM5
4 spiradenoma 29.3 PIP KRT7 KRT5 CYLD CEACAM5
5 colorectal adenocarcinoma 29.3 TP53 KRT7 CEACAM5
6 sweat gland benign neoplasm 29.2 TP53 PIP KRT7 KRT5 CYLD CEACAM5
7 salivary gland adenoid cystic carcinoma 29.1 TP53 PIP KRT7 KRT5 CYLD
8 sweat gland cancer 28.6 TP53 PIP KRT7 KRT5 ESR1 CEACAM5
9 breast malignant eccrine spiradenoma 11.5
10 meckel syndrome, type 1 11.1
11 uterine corpus sarcoma 10.5
12 uterine sarcoma 10.5
13 sarcoma 10.5
14 fanconi anemia, complementation group e 10.3
15 carcinosarcoma 10.3
16 hypereosinophilic syndrome 10.2
17 squamous cell carcinoma 10.2
18 bartholin's gland adenoid cystic carcinoma 10.2 KRT7 CYLD
19 anal canal paget's disease 10.2 PIP KRT7
20 anal gland adenocarcinoma 10.2 PIP KRT7
21 bartholin's gland adenocarcinoma 10.2 PIP KRT7
22 anus adenocarcinoma 10.2 PIP KRT7
23 anal canal adenocarcinoma 10.2 PIP KRT7
24 gastric signet ring cell adenocarcinoma 10.2 PIP KRT7
25 adenofibroma 10.2 TP53 KRT7
26 bile duct adenoma 10.1 TP53 KRT7
27 eyelid carcinoma 10.1 PIP KRT7
28 47 xxx syndrome 10.1
29 meibomian cyst 10.1 PIP KRT7
30 erysipeloid 10.1 PIP KRT7
31 bartholin's gland disease 10.1 PIP KRT7
32 ovarian mesodermal adenosarcoma 10.1 KRT7 ESR1
33 atrophic vulva 10.1 KRT7 ESR1
34 mixed lacrimal gland cancer 10.1 PIP KRT7
35 breast cancer 10.1
36 posttransplant acute limbic encephalitis 10.1
37 breast hemangioma 10.1 TP53 KRT7
38 vaginal carcinosarcoma 10.1 TP53 KRT7
39 intratubular embryonal carcinoma 10.1 TP53 KRT7
40 basosquamous carcinoma 10.1 TP53 KRT7
41 ureteral benign neoplasm 10.1 TP53 KRT7
42 ovarian seromucinous carcinoma 10.1 KRT7 ESR1
43 papillary transitional carcinoma 10.1 TP53 KRT7
44 squamous cell papilloma 10.1 TP53 KRT7
45 cystadenofibroma 10.1 TP53 KRT7
46 bladder transitional cell papilloma 10.1 TP53 KRT7
47 breast adenomyoepithelioma 10.1 KRT7 KRT5
48 glandular cystitis 10.1 TP53 KRT7
49 brooke-spiegler syndrome 10.1 KRT7 CYLD
50 ovarian serous cystadenofibroma 10.1 TP53 KRT7

Graphical network of the top 20 diseases related to Malignant Spiradenoma:



Diseases related to Malignant Spiradenoma

Symptoms & Phenotypes for Malignant Spiradenoma

MGI Mouse Phenotypes related to Malignant Spiradenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.1 CEACAM5 CYLD ESR1 KRT5 PIP TP53

Drugs & Therapeutics for Malignant Spiradenoma

Search Clinical Trials, NIH Clinical Center for Malignant Spiradenoma

Genetic Tests for Malignant Spiradenoma

Anatomical Context for Malignant Spiradenoma

Organs/tissues related to Malignant Spiradenoma:

MalaCards : Skin, Lymph Node, Smooth Muscle, Breast

Publications for Malignant Spiradenoma

Articles related to Malignant Spiradenoma:

(show top 50) (show all 58)
# Title Authors PMID Year
1
Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review. 62
35717180 2022
2
Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review. 62
33522696 2021
3
A rare case of malignant eccrine spiradenoma mimicking carcinosarcoma. 62
33851645 2021
4
Malignant Eccrine Adenoma With Sarcomatous (Heterologous) Components: Report of a Rare Skin Adnexal Neoplasm With Literature Review. 62
33532153 2020
5
Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV. 62
32169099 2020
6
Malignant Eccrine Spiradenoma of the External Auditory Canal: A Case Report and Literature Review. 62
33469512 2020
7
[Malignant transformation of an eccrine spiradenoma]. 62
28277254 2017
8
FDG PET/CT in Malignant Eccrine Spiradenoma. 62
28005641 2017
9
Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. 62
26563774 2016
10
Zosteriform configuration of multiple eccrine spiradenomas of the scalp. 62
25555434 2016
11
Skin spiradenocarcinoma - case presentation. 62
27151731 2016
12
Malignant Eccrine Spiradenoma of the Face. 62
26167988 2015
13
Malignant eccrine spiradenoma of the external ear. 62
26211868 2015
14
A malignant eccrine spiradenoma of the scalp. 62
24842352 2014
15
Malignant spiradenoma/cylindroma of the vulva. 62
23147883 2012
16
Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses. 62
23056620 2012
17
Rare tumors through the looking glass: an examination of malignant cutaneous adnexal tumors. 62
21931043 2011
18
Malignant eccrine spiradenoma: a meta-analysis of reported cases. 62
20851376 2011
19
A rare case of giant malignant eccrine spiradenoma. 62
21342314 2011
20
Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. 62
20483125 2010
21
Malignant eccrine spiradenoma: a new case report. 62
19614990 2010
22
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. 62
19222500 2010
23
Direct intracranial extension of malignant eccrine spiradenoma of the face. 62
22493654 2009
24
Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. 62
20101314 2009
25
Malignant eccrine spiradenoma of the scalp. 62
19098562 2008
26
A case of malignant eccrine spiradenoma metastatic to intramammary lymph node. 62
18270794 2008
27
Malignant eccrine spiradenoma. 62
17474253 2007
28
De novo malignant eccrine spiradenoma: a case report and review of the literature. 62
16970705 2006
29
Malignant eccrine spiradenoma of the vulva: a case report and review of the literature. 62
16803551 2006
30
Malignant eccrine spiradenoma: a case report with pulmonary metastasis. 62
14989745 2004
31
Low-grade malignant eccrine spiradenoma with systemic metastases. 62
12775989 2003
32
Linear spiradenoma with focal malignant transformation. 62
12702073 2003
33
Malignant eccrine spiradenoma: an unusual presentation. 62
17656974 2002
34
Malignant eccrine spiradenoma occurring on a traumatized area. 62
12087301 2002
35
Malignant eccrine spiradenoma. 62
11958666 2002
36
[Eccrine spiradenocarcinoma with unusual histiocytic giant cell components. Case report and review of the literature of a rare sweat gland tumor]. 62
12001532 2002
37
Malignant eccrine spiradenoma of the neck: a case report. 62
11593191 2001
38
De novo malignant eccrine spiradenoma with an interesting and unusual location. 62
11298720 2001
39
Commentary on malignant eccrine spiradenoma. 62
11277909 2001
40
Malignant spiradenoma: report of two cases and literature review. 62
11174426 2001
41
Malignant eccrine spiradenoma: a case report and review of the literature. 62
11231249 2001
42
Malignant eccrine spiradenoma (spiradenocarcinoma): a clinicopathologic study of 12 cases. 62
10770427 2000
43
Guess what! Malignant eccrine spiradenoma. 62
10702011 2000
44
Malignant eccrine spiradenoma: a previously unreported presentation and review of the literature. 62
10075300 1999
45
Giant malignant eccrine spiradenoma of the scalp. 62
9935094 1999
46
Malignant eccrine spiradenoma with florid squamous differentiation. 62
9610621 1998
47
Malignant eccrine spiradenoma. Case report and review of the literature. 62
9391538 1997
48
Malignant eccrine spiradenoma with carcinomatous and sarcomatous elements. 62
9462275 1997
49
Malignant eccrine spiradenoma with smooth muscle cell differentiation: histological and immunohistochemical study. 62
8970199 1996
50
Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. 62
8639057 1996

Variations for Malignant Spiradenoma

Expression for Malignant Spiradenoma

Search GEO for disease gene expression data for Malignant Spiradenoma.

Pathways for Malignant Spiradenoma

Pathways related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 TP53 ESR1
2 10.52 TP53 ESR1
3 10.14 TP53 ESR1

GO Terms for Malignant Spiradenoma

Biological processes related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 necroptotic process GO:0070266 9.46 TP53 CYLD
2 negative regulation of miRNA maturation GO:1903799 9.13 TP53 ESR1
3 positive regulation of RNA polymerase II transcription preinitiation complex assembly GO:0045899 8.92 TP53 ESR1

Sources for Malignant Spiradenoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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