MES
MCID: MLG036
MIFTS: 33

Malignant Spiradenoma (MES)

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Malignant Spiradenoma

MalaCards integrated aliases for Malignant Spiradenoma:

Name: Malignant Spiradenoma 12 15
Malignant Eccrine Spiradenoma 12 53 73
Eccrine Spiradenoma, Malignant 53
Mes 53

Classifications:



External Ids:

Disease Ontology 12 DOID:7960
NCIt 50 C5117
UMLS 73 C1266063

Summaries for Malignant Spiradenoma

NIH Rare Diseases : 53 Malignant eccrine spiradenoma is a type of tumor that develops from a sweat gland in the skin.  It starts as a rapidly-growing bump on the head or abdomen, and may cause tenderness, redness, or an open wound.  The exact cause of malignant eccrine spiradenoma is unknown, though it is thought that sun exposure or problems with the immune system (immunosuppression) may contribute to the development of this tumor.  Because malignant eccrine spiradenoma is quite rare, there are no established treatment guidelines; however, in practice, surgery is often performed to remove the tumor and additional treatments may follow, depending on the severity and extent of the cancer.

MalaCards based summary : Malignant Spiradenoma, also known as malignant eccrine spiradenoma, is related to spiradenoma and benign mesothelioma. An important gene associated with Malignant Spiradenoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Platinum drug resistance and p75(NTR)-mediated signaling. The drugs Adcetris and Afinitor have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and liver.

Related Diseases for Malignant Spiradenoma

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Malignant Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 450)
# Related Disease Score Top Affiliating Genes
1 spiradenoma 30.5 KRT7 TP53
2 benign mesothelioma 29.9 KRT5 KRT7
3 cervical cancer 29.3 KRT5 PIK3CA TP53
4 gallbladder cancer 29.2 CEACAM5 PIK3CA TP53
5 papillary adenocarcinoma 29.2 CEACAM5 KRT7 TP53
6 ovarian cancer 1 28.9 CEACAM5 KRT7 PIK3CA TP53
7 gastric adenocarcinoma 28.5 CEACAM5 KRT7 PIK3CA SMUG1 TP53
8 breast malignant eccrine spiradenoma 12.4
9 chronic fatigue syndrome 11.8
10 atrial fibrillation 11.3
11 meckel syndrome, type 1 11.3
12 aplastic anemia 11.1
13 hemolytic anemia 11.1
14 atrial standstill 1 11.0
15 pernicious anemia 11.0
16 fanconi anemia, complementation group a 11.0
17 hemochromatosis, type 1 11.0
18 polycythemia vera 11.0
19 sickle cell anemia 11.0
20 deficiency anemia 11.0
21 long qt syndrome 11.0
22 myocardial infarction 10.5
23 sarcoma 10.2
24 keratosis, seborrheic 10.2 KRT5 PIK3CA
25 primary cutaneous amyloidosis 10.2 KRT5 KRT7
26 spindle cell carcinoma 10.2 KRT5 KRT7
27 uterine sarcoma 10.1
28 inverted transitional papilloma 10.1 KRT5 KRT7
29 balloon cell malignant melanoma 10.1 KRT5 KRT7
30 benign breast adenomyoepithelioma 10.1 KRT5 KRT7
31 ceruminoma 10.1 KRT5 KRT7
32 esophageal adenosquamous carcinoma 10.1 CEACAM5 KRT5
33 sensory organ benign neoplasm 10.1 KRT5 KRT7
34 middle ear adenoma 10.1 KRT5 KRT7
35 large cell acanthoma 10.1 KRT5 KRT7
36 apocrine sweat gland neoplasm 10.1 KRT5 KRT7
37 ductal carcinoma in situ 10.1 KRT5 TP53
38 polycystic liver disease 1 with or without kidney cysts 10.1 CEACAM5 KRT7
39 in situ carcinoma 10.1 KRT5 TP53
40 breast carcinoma in situ 10.1 KRT5 TP53
41 apocrine adenoma 10.1 CEACAM5 PIK3CA
42 bile duct disease 10.1 CEACAM5 KRT7
43 biliary tract disease 10.1 CEACAM5 KRT7
44 mucoepidermoid carcinoma 10.1 CEACAM5 KRT7
45 hidradenoma 10.1 KRT7 PIK3CA
46 estrogen-receptor positive breast cancer 10.1 PIK3CA TP53
47 penile cancer 10.1 PIK3CA TP53
48 aggressive digital papillary adenocarcinoma 10.1 CEACAM5 PIK3CA
49 peritoneum cancer 10.1 KRT5 KRT7
50 serous cystadenocarcinoma 10.1 PIK3CA TP53

Graphical network of the top 20 diseases related to Malignant Spiradenoma:



Diseases related to Malignant Spiradenoma

Symptoms & Phenotypes for Malignant Spiradenoma

Drugs & Therapeutics for Malignant Spiradenoma

FDA approved drugs:

(show top 50) (show all 61)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Adcetris 18 49 BRENTUXIMAB VEDOTIN Seattle Genetics August 2011
2
Afinitor 18 49 EVEROLIMUS Novartis March 2009
3
Akynzeo 18 49 NETUPITANT AND PALONOSETRON (hydrochloride) Helsinn October 2014
4
Alimta 18 49 PEMETREXED (also Pemetrexed Disodium) Eli Lilly February 2004
5
Anzemet 18 DOLASETRON MESYLATE Hoechst Marion Roussel February 1998
6
Aredia 18 49 PAMIDRONATE DISODIUM Chiron August 1996
7
Aromasin Tablets 18 49 EXEMESTANE Pharmacia & Upjohn October 21. 1999
8
Bexxar 18 49 TOSITUMOMAB; IODINE I 131 TOSITUMOMAB Corixa June 2003
9
Cometriq 18 49 CABOZANTINIB S-MALATE Exelixis November 2012
10
Degarelix 18 49 degarelix Ferring Pharmaceuticals December of 2008
11
Doxil 18 49 DOXORUBICIN HYDROCHLORIDE Alza June 1999
12
Emend 18 49 APREPITANT FOSAPREPITANT DIMEGLUMINE Merck March 2003
13
Erbitux 18 49 CETUXIMAB Imclone, Bristol-Myers Squibb February 2004
14
Erwinaze 18 49 asparaginase Erwinia chrysanthemi Eusa Pharma November of 2011
15
Eulexin 18 FLUTAMIDE Schering-Plough June 1996
16
Evista 18 49 RALOXIFENE HYDROCHLORIDE Eli Lilly September 2007
17
Farydak 18 49 PANOBINOSTAT LACTATE Novartis February 2015
18
Gardasil 18 49 quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine Merck June 2006
19
Gleevec 18 49 IMATINIB MESYLATE Novartis May 2001
20
Halaven 18 49 ERIBULIN MESYLATE Eisai November 2010
21
Intron A 18 49 INTERFERON ALFA-2B Schering-Plough December 1997/ December 1995/ March 1997
22
Lynparza 18 49 OLAPARIB AstraZeneca December 2014
23
Marqibo 18 49 VINCRISTINE SULFATE Talon Therapeutics August 2012
24
Miraluma Test 18 TECHNETIUM TC-99M SESTAMIBI KIT DuPont Merck Pharmaceutical Company May 1997
25
Mylotarg 18 49 GEMTUZUMAB OZOGAMICIN Wyeth May 2000
26
Premarin 18 ESTROGENS CONJUGATED Wyeth July of 2003
27
Revlimid 18 49 LENALIDOMIDE Celgene June 2013
28
Rituxan 18 49 RITUXIMAB Biogen IDEC, Genentech November 1997
29
Sensipar 18 CINACALCET HYDROCHLORIDE Amgen March 2004
30
Stivarga 18 49 REGORAFENIB Bayer/ Bayer HealthCare Pharmaceuticals February 2013/ September 2012
31
Sutent 18 49 SUNITINIB MALATE Pfizer May 2011/ January 2006
32
Synercid I.V. 18 DALFOPRISTIN; QUINUPRISTIN QUINUPRISTIN; DALFOPRISTIN Rhone Poulenc Rorer September 1999
33
Taxotere 18 49 DOCETAXEL Rhone Poulenc Rorer May 1996
34
UroXatral 18 ALFUZOSIN HYDROCHLORIDE Sanofi-aventis June 2003
35
Xalkori 18 49 CRIZOTINIB Pfizer August of 2011
36
Zuplenz 18 ONDANSETRON Strativa Pharmaceuticals July 2010
37
Adempas 18 RIOCIGUAT Bayer Healthcare Pharmaceuticals October 2013
38
Advair 18 FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE GlaxoSmithKline August 2000
39
Aldurazyme 18 LARONIDASE Genzyme May 2003
40
Alvesco 18 CICLESONIDE Nycomed January 2008
41
Atrovent 18 IPRATROPIUM BROMIDE Boehringer Ingelheim January 1996
42
Augmentin 18 AMOXICILLIN; CLAVULANATE POTASSIUM SmithKline Beecham February 1996
43
Azmacort 18 TRIAMCINOLONE ACETONIDE Rhone Poulenc Rorer November 1996
44
Cayston 18 AZTREONAM Gilead February 2010
45
Cedax 18 CEFTIBUTEN DIHYDRATE Schering-Plough December 1995
46
Dulera 18 FORMOTEROL FUMARATE; MOMETASONE FUROATE Merck June 2010
47
Esbriet 18 PIRFENIDONE InterMune October 2014
48
Ketek 18 TELITHROMYCIN Sanofi-aventis April 2004
49
Nasacort AQ Nasal Spray 18 TRIAMCINOLONE ACETONIDE Phone-Poulenc Rorer October 1997
50
Patanase 18 OLOPATADINE HYDROCHLORIDE Alcon April 2008

Drugs for Malignant Spiradenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 2
3 Antibodies Phase 2
4 Immunoglobulins Phase 2
5 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Malignant Spiradenoma

Genetic Tests for Malignant Spiradenoma

Anatomical Context for Malignant Spiradenoma

MalaCards organs/tissues related to Malignant Spiradenoma:

41
Skin, Lung, Liver, Heart, Ovary, Prostate, B Cells

Publications for Malignant Spiradenoma

Articles related to Malignant Spiradenoma:

(show all 41)
# Title Authors Year
1
FDG PET/CT in Malignant Eccrine Spiradenoma. ( 28005641 )
2017
2
Malignant eccrine spiradenoma of the external ear. ( 26211868 )
2015
3
Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. ( 26563774 )
2015
4
Malignant Eccrine Spiradenoma of the Face. ( 26167988 )
2015
5
A malignant eccrine spiradenoma of the scalp. ( 24842352 )
2014
6
Malignant spiradenoma/cylindroma of the vulva. ( 23147883 )
2012
7
Malignant eccrine spiradenoma: a meta-analysis of reported cases. ( 20851376 )
2011
8
A rare case of giant malignant eccrine spiradenoma. ( 21342314 )
2011
9
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. ( 19222500 )
2010
10
Malignant eccrine spiradenoma: a new case report. ( 19614990 )
2010
11
Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. ( 20483125 )
2010
12
Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. ( 20101314 )
2009
13
Direct intracranial extension of malignant eccrine spiradenoma of the face. ( 22493654 )
2009
14
Malignant eccrine spiradenoma of the scalp. ( 19098562 )
2008
15
A case of malignant eccrine spiradenoma metastatic to intramammary lymph node. ( 18270794 )
2008
16
Malignant eccrine spiradenoma. ( 17474253 )
2007
17
Malignant eccrine spiradenoma of the vulva: a case report and review of the literature. ( 16803551 )
2006
18
De novo malignant eccrine spiradenoma: a case report and review of the literature. ( 16970705 )
2006
19
Malignant eccrine spiradenoma: a case report with pulmonary metastasis. ( 14989745 )
2004
20
Low-grade malignant eccrine spiradenoma with systemic metastases. ( 12775989 )
2003
21
Malignant eccrine spiradenoma occurring on a traumatized area. ( 12087301 )
2002
22
Malignant eccrine spiradenoma: an unusual presentation. ( 17656974 )
2002
23
Malignant eccrine spiradenoma. ( 11958666 )
2002
24
Malignant eccrine spiradenoma: a case report and review of the literature. ( 11231249 )
2001
25
Malignant spiradenoma: report of two cases and literature review. ( 11174426 )
2001
26
De novo malignant eccrine spiradenoma with an interesting and unusual location. ( 11298720 )
2001
27
Malignant eccrine spiradenoma of the neck: a case report. ( 11593191 )
2001
28
Commentary on malignant eccrine spiradenoma. ( 11277909 )
2001
29
Malignant eccrine spiradenoma (spiradenocarcinoma): a clinicopathologic study of 12 cases. ( 10770427 )
2000
30
Guess what! Malignant eccrine spiradenoma. ( 10702011 )
2000
31
Malignant eccrine spiradenoma: a previously unreported presentation and review of the literature. ( 10075300 )
1999
32
Giant malignant eccrine spiradenoma of the scalp. ( 9935094 )
1999
33
Malignant eccrine spiradenoma with florid squamous differentiation. ( 9610621 )
1998
34
Malignant eccrine spiradenoma with carcinomatous and sarcomatous elements. ( 9462275 )
1997
35
Malignant eccrine spiradenoma. Case report and review of the literature. ( 9391538 )
1997
36
Malignant eccrine spiradenoma with smooth muscle cell differentiation: histological and immunohistochemical study. ( 8970199 )
1996
37
An uncommon breast tumour: the malignant eccrine spiradenoma. A case report. ( 8140844 )
1993
38
Malignant eccrine spiradenoma. A clinicopathologic study. ( 1384379 )
1992
39
Malignant eccrine spiradenoma of the hand. ( 2154644 )
1990
40
Fine needle aspiration cytology of malignant spiradenoma arising in congenital eccrine spiradenoma. ( 2157326 )
1990
41
Sweat gland carcinoma of the hand: two cases of malignant eccrine spiradenoma. ( 6096437 )
1984

Variations for Malignant Spiradenoma

Expression for Malignant Spiradenoma

Search GEO for disease gene expression data for Malignant Spiradenoma.

Pathways for Malignant Spiradenoma

Pathways related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 PIK3CA TP53
2
Show member pathways
11.08 PIK3CA TP53
3 10.98 PIK3CA TP53
4 10.77 PIK3CA TP53
5 10.36 PIK3CA TP53

GO Terms for Malignant Spiradenoma

Biological processes related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 base-excision repair GO:0006284 8.96 SMUG1 TP53
2 negative regulation of anoikis GO:2000811 8.62 CEACAM5 PIK3CA

Sources for Malignant Spiradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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