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MES
MCID: MLG036
MIFTS: 37

Malignant Spiradenoma (MES)

Categories: Cancer diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Malignant Spiradenoma

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MalaCards integrated aliases for Malignant Spiradenoma:

Name: Malignant Spiradenoma 12 15
Malignant Eccrine Spiradenoma 12 20 70
Eccrine Spiradenoma, Malignant 20
Mes 20

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:7960
NCIt 50 C5117
SNOMED-CT 67 403942003
UMLS 70 C1266063
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Summaries for Malignant Spiradenoma

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GARD : 20 Malignant eccrine spiradenoma is a type of tumor that develops from a sweat gland in the skin. It starts as a rapidly-growing bump on the head or abdomen, and may cause tenderness, redness, or an open wound. The exact cause of malignant eccrine spiradenoma is unknown, though it is thought that sun exposure or problems with the immune system ( immunosuppression ) may contribute to the development of this tumor. Because malignant eccrine spiradenoma is quite rare, there are no established treatment guidelines; however, in practice, surgery is often performed to remove the tumor and additional treatments may follow, depending on the severity and extent of the cancer.

MalaCards based summary : Malignant Spiradenoma, also known as malignant eccrine spiradenoma, is related to spiradenoma and sarcoma. An important gene associated with Malignant Spiradenoma is KRT7 (Keratin 7), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. Affiliated tissues include skin, lymph node and smooth muscle, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Malignant Spiradenoma

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Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Malignant Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 513)
# Related Disease Score Top Affiliating Genes
1 spiradenoma 30.9 TP53 KRT7 CYLD
2 sarcoma 30.2 TP53 PIK3CG PIK3CA MTOR MDM2
3 sweat gland cancer 29.8 TP53 PLIN2 PIP PGR KRT7 KRT5
4 colorectal adenocarcinoma 29.8 TP53 KRT7 CEACAM5 CDKN2A
5 glioma 29.6 TP53 PIK3CA MDM2 CDKN2A
6 carcinosarcoma 29.6 TP53 PIK3CA PGR KRT7 CDKN2A CALB2
7 ovarian cancer 27.7 TP53 PIK3CG PIK3CA PGR MTOR MDM2
8 breast malignant eccrine spiradenoma 11.5
9 meckel syndrome, type 1 11.1
10 uterine sarcoma 10.5
11 spindle cell sarcoma 10.5
12 leukoplakia of penis 10.5 KRT7 CEACAM5
13 mucinous adenofibroma 10.4 KRT7 CEACAM5
14 gastric signet ring cell adenocarcinoma 10.4 PIP KRT7
15 ureter squamous cell carcinoma 10.4 KRT7 KRT5
16 pancreatic serous cystadenocarcinoma 10.4 KRT7 CEACAM5
17 urinary bladder villous adenoma 10.4 KRT7 CEACAM5
18 adult teratoma 10.4 TP53 CEACAM5
19 bartholin's gland carcinoma 10.4 PIP KRT7
20 female urethral cancer 10.4 KRT7 CEACAM5
21 subareolar duct papillomatosis 10.4 KRT7 KRT5
22 fox-fordyce disease 10.4 PIP CEACAM5
23 nipple benign neoplasm 10.4 KRT7 KRT5
24 renal pelvis adenocarcinoma 10.4 KRT7 CEACAM5
25 bartholin's gland adenoid cystic carcinoma 10.4 PGR KRT7
26 bile duct cystadenocarcinoma 10.4 KRT7 CEACAM5
27 auditory system benign neoplasm 10.4 KRT7 KRT5
28 mucinous ovarian cystadenoma 10.4 KRT7 CEACAM5
29 rectosigmoid junction neoplasm 10.4 KRT7 CEACAM5
30 transverse colon cancer 10.4 KRT7 CEACAM5
31 sigmoid neoplasm 10.4 KRT7 CEACAM5
32 microinvasive cervical squamous cell carcinoma 10.4 KRT7 KRT5
33 nodular hidradenoma 10.4 PIP CEACAM5
34 bartholin's gland adenoma 10.4 TP53 PGR
35 bartholin's gland benign neoplasm 10.4 TP53 PGR
36 vestibular gland benign neoplasm 10.4 TP53 PGR
37 breast cystic hypersecretory carcinoma 10.4 KRT5 CEACAM5
38 gallbladder squamous cell carcinoma 10.4 KRT5 CEACAM5
39 thymus adenocarcinoma 10.4 KRT5 CEACAM5
40 benign breast adenomyoepithelioma 10.4 KRT7 KRT5
41 krukenberg carcinoma 10.4 KRT7 CEACAM5
42 fallopian tube endometriosis 10.4 PGR CEACAM5
43 ring chromosome 7 10.4 TP53 MDM2
44 granulomatous endometritis 10.4 PGR CEACAM5
45 adenoid basal cell carcinoma 10.4 KRT7 CEACAM5
46 vaginal glandular tumor 10.4 PGR CEACAM5
47 appendiceal neoplasm 10.4 KRT7 CEACAM5
48 colonic lymphangioma 10.4 KRT7 CEACAM5
49 eyelid carcinoma 10.4 PIP KRT7
50 pediatric angiosarcoma 10.4 TP53 TCHP

Graphical network of the top 20 diseases related to Malignant Spiradenoma:



Diseases related to Malignant Spiradenoma
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Symptoms & Phenotypes for Malignant Spiradenoma

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GenomeRNAi Phenotypes related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

26 (show all 13)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.07 MTOR PIK3CA
2 Decreased viability GR00055-A-2 10.07 MTOR PIK3CA
3 Decreased viability GR00221-A-1 10.07 CDKN2A CYLD MTOR PIK3CA PIK3CG
4 Decreased viability GR00221-A-2 10.07 CYLD PIK3CA PIK3CG
5 Decreased viability GR00221-A-3 10.07 CDKN2A
6 Decreased viability GR00221-A-4 10.07 CDKN2A MTOR PIK3CA PIK3CG
7 Decreased viability GR00249-S 10.07 CYLD
8 Decreased viability GR00301-A 10.07 CYLD
9 Decreased viability GR00342-S-1 10.07 MTOR
10 Decreased viability GR00342-S-2 10.07 MTOR PIK3CG
11 Decreased viability GR00342-S-3 10.07 PIK3CG
12 Decreased viability GR00402-S-2 10.07 CYLD PIK3CA PIK3CG
13 Increased cell death in HCT116 cells GR00103-A-0 8.62 MDM2 PIK3CA

MGI Mouse Phenotypes related to Malignant Spiradenoma:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 CALB2 CD200 CDKN2A CYLD KRT5 MDM2
2 cellular MP:0005384 10.29 CD200 CDKN2A CLDN4 CYLD KRT7 MDM2
3 homeostasis/metabolism MP:0005376 10.25 CD200 CDKN2A CLDN4 CYLD KRT7 MDM2
4 hematopoietic system MP:0005397 10.21 CD200 CDKN2A CLDN4 CYLD MDM2 MTOR
5 cardiovascular system MP:0005385 10.19 CDKN2A CLDN4 MDM2 MTOR PGR PIK3CA
6 immune system MP:0005387 10.18 CD200 CDKN2A CYLD KRT5 MDM2 MTOR
7 endocrine/exocrine gland MP:0005379 10.16 CDKN2A CYLD MDM2 MTOR PGR PIK3CA
8 integument MP:0010771 10.02 CDKN2A CYLD KRT5 MDM2 PGR PIK3CA
9 muscle MP:0005369 9.86 CDKN2A MDM2 MTOR PGR PIK3CA PIK3CG
10 neoplasm MP:0002006 9.7 CDKN2A CYLD MDM2 PGR PIK3CA PTGER4
11 normal MP:0002873 9.56 CALB2 CLDN4 CYLD MDM2 MTOR PGR
12 skeleton MP:0005390 9.32 CD200 CDKN2A MDM2 MTOR PGR PIK3CA
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Drugs & Therapeutics for Malignant Spiradenoma

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Search Clinical Trials , NIH Clinical Center for Malignant Spiradenoma

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Genetic Tests for Malignant Spiradenoma

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Anatomical Context for Malignant Spiradenoma

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MalaCards organs/tissues related to Malignant Spiradenoma:

40
Skin, Lymph Node, Smooth Muscle
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Publications for Malignant Spiradenoma

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Articles related to Malignant Spiradenoma:

(show top 50) (show all 56)
# Title Authors PMID Year
1
Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review. 61
33522696 2021
2
Malignant Eccrine Adenoma With Sarcomatous (Heterologous) Components: Report of a Rare Skin Adnexal Neoplasm With Literature Review. 61
33532153 2020
3
Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV. 61
32169099 2020
4
Malignant Eccrine Spiradenoma of the External Auditory Canal: A Case Report and Literature Review. 61
33469512 2020
5
[Malignant transformation of an eccrine spiradenoma]. 61
28277254 2017
6
FDG PET/CT in Malignant Eccrine Spiradenoma. 61
28005641 2017
7
Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. 61
26563774 2016
8
Zosteriform configuration of multiple eccrine spiradenomas of the scalp. 61
25555434 2016
9
Skin spiradenocarcinoma - case presentation. 61
27151731 2016
10
Malignant Eccrine Spiradenoma of the Face. 61
26167988 2015
11
Malignant eccrine spiradenoma of the external ear. 61
26211868 2015
12
A malignant eccrine spiradenoma of the scalp. 61
24842352 2014
13
Malignant spiradenoma/cylindroma of the vulva. 61
23147883 2012
14
Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses. 61
23056620 2012
15
Rare tumors through the looking glass: an examination of malignant cutaneous adnexal tumors. 61
21931043 2011
16
Malignant eccrine spiradenoma: a meta-analysis of reported cases. 61
20851376 2011
17
A rare case of giant malignant eccrine spiradenoma. 61
21342314 2011
18
Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. 61
20483125 2010
19
Malignant eccrine spiradenoma: a new case report. 61
19614990 2010
20
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. 61
19222500 2010
21
Direct intracranial extension of malignant eccrine spiradenoma of the face. 61
22493654 2009
22
Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. 61
20101314 2009
23
Malignant eccrine spiradenoma of the scalp. 61
19098562 2008
24
A case of malignant eccrine spiradenoma metastatic to intramammary lymph node. 61
18270794 2008
25
Malignant eccrine spiradenoma. 61
17474253 2007
26
De novo malignant eccrine spiradenoma: a case report and review of the literature. 61
16970705 2006
27
Malignant eccrine spiradenoma of the vulva: a case report and review of the literature. 61
16803551 2006
28
Malignant eccrine spiradenoma: a case report with pulmonary metastasis. 61
14989745 2004
29
Low-grade malignant eccrine spiradenoma with systemic metastases. 61
12775989 2003
30
Linear spiradenoma with focal malignant transformation. 61
12702073 2003
31
Malignant eccrine spiradenoma: an unusual presentation. 61
17656974 2002
32
Malignant eccrine spiradenoma occurring on a traumatized area. 61
12087301 2002
33
Malignant eccrine spiradenoma. 61
11958666 2002
34
[Eccrine spiradenocarcinoma with unusual histiocytic giant cell components. Case report and review of the literature of a rare sweat gland tumor]. 61
12001532 2002
35
Malignant eccrine spiradenoma of the neck: a case report. 61
11593191 2001
36
De novo malignant eccrine spiradenoma with an interesting and unusual location. 61
11298720 2001
37
Commentary on malignant eccrine spiradenoma. 61
11277909 2001
38
Malignant spiradenoma: report of two cases and literature review. 61
11174426 2001
39
Malignant eccrine spiradenoma: a case report and review of the literature. 61
11231249 2001
40
Malignant eccrine spiradenoma (spiradenocarcinoma): a clinicopathologic study of 12 cases. 61
10770427 2000
41
Guess what! Malignant eccrine spiradenoma. 61
10702011 2000
42
Malignant eccrine spiradenoma: a previously unreported presentation and review of the literature. 61
10075300 1999
43
Giant malignant eccrine spiradenoma of the scalp. 61
9935094 1999
44
Malignant eccrine spiradenoma with florid squamous differentiation. 61
9610621 1998
45
Malignant eccrine spiradenoma. Case report and review of the literature. 61
9391538 1997
46
Malignant eccrine spiradenoma with carcinomatous and sarcomatous elements. 61
9462275 1997
47
Malignant eccrine spiradenoma with smooth muscle cell differentiation: histological and immunohistochemical study. 61
8970199 1996
48
Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. 61
8639057 1996
49
Over-expression of p53 protein as an indicator of the malignant transformation in spiradenoma. 61
7657312 1995
50
An uncommon breast tumour: the malignant eccrine spiradenoma. A case report. 61
8140844 1993
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Variations for Malignant Spiradenoma

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Expression for Malignant Spiradenoma

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Search GEO for disease gene expression data for Malignant Spiradenoma.
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Pathways for Malignant Spiradenoma

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Pathways related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
PI3K-Akt signaling pathway 36
Show member pathways
 12.91 TP53 PTGER4 PIK3CG PIK3CA MTOR MDM2
2
Endometrial cancer 36
Show member pathways
 12.81 TP53 PIK3CA MTOR MDM2 CDKN2A
3
Pathways in cancer 36
12.71 TP53 PTGER4 PIK3CA MTOR MDM2 CDKN2A
4
Gastric cancer 36
Show member pathways
 12.7 TP53 PIK3CA PGR MTOR CDKN2A
5
ErbB signaling pathway 36 1
Show member pathways
 12.54 TP53 PIK3CG PIK3CA MTOR MDM2
6
Human cytomegalovirus infection 36
Show member pathways
 12.5 TP53 PTGER4 PIK3CG PIK3CA MTOR MDM2
7
MicroRNAs in cancer 36
12.46 TP53 PIK3CA MTOR MDM2 CDKN2A
8
mTOR signaling pathway (KEGG) 36
Show member pathways
 12.45 TP53 PIK3CG PIK3CA MTOR
9
Glioma 36
Show member pathways
 12.45 TP53 PIK3CG PIK3CA MTOR MDM2 CDKN2A
10
AMP-activated Protein Kinase (AMPK) Signaling 1
Show member pathways
 12.43 TP53 PIK3CG PIK3CA MTOR
11
VEGF Signaling 66
Show member pathways
 12.4 TP53 PIK3CG PIK3CA MTOR MDM2
12
Shigellosis 36
12.35 TP53 PIK3CA MTOR MDM2
13
Development IGF-1 receptor signaling 23
Show member pathways
 12.34 TP53 PIK3CA MTOR MDM2
14
Apoptosis Pathway 69
Show member pathways
 12.3 TP53 PIK3CG PIK3CA MTOR MDM2
15
Translation Non-genomic (rapid) action of Androgen Receptor 23
Show member pathways
 12.25 TP53 PIK3CA MTOR MDM2
16
Proteoglycans in cancer 36
12.24 TP53 PIK3CA MTOR MDM2
17
Viral carcinogenesis 36
12.23 TP53 PIK3CA MDM2 CDKN2A
18
MAPK Signaling: Mitogen Stimulation Pathway 64
Show member pathways
 12.16 TP53 PIK3CG PIK3CA MTOR MDM2
19
mTOR Pathway 69
Show member pathways
 12.1 TP53 PIK3CG PIK3CA MTOR
20
Thyroid hormone signaling pathway 36
11.93 TP53 PIK3CA MTOR MDM2
21
Glioblastoma Multiforme 63
11.84 TP53 MTOR MDM2 CDKN2A
22
Type II diabetes mellitus 1 36
Show member pathways
 11.83 PIK3CG PIK3CA MTOR
23
PI3K / Akt Signaling 4
11.81 PIK3CG PIK3CA MDM2
24
Senescence and Autophagy in Cancer 1
11.78 TP53 MTOR MDM2 CDKN2A
25
Glucocorticoid receptor regulatory network 1
11.75 TP53 MDM2 KRT5
26
Bladder cancer 36 1
11.69 TP53 MDM2 CDKN2A
27
Commom Cytokine Receptor G Chain Siganaling Pathway 66
11.68 PIK3CG PIK3CA MTOR
28
Central carbon metabolism in cancer 36
11.66 TP53 PIK3CA MTOR
29
Cellular senescence (KEGG) 36
11.55 TP53 PIK3CA MTOR MDM2 CDKN2A
30
HIF1Alpha Pathway 63
11.52 TP53 MDM2 CDKN2A
31
Copper homeostasis 1
11.51 TP53 PIK3CA MDM2
32
Regulation of TP53 Expression and Degradation 65
Show member pathways
 11.49 TP53 MTOR MDM2 CDKN2A
33
Platinum drug resistance 36
11.42 TP53 PIK3CA MDM2 CDKN2A
34
Oncogene Induced Senescence 65
11.24 TP53 MDM2 CDKN2A
35
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
11.18 PIK3CG PIK3CA MTOR
36
DNA Damage Response (only ATM dependent) 1
11.08 TP53 PIK3CG PIK3CA MDM2 CDKN2A
37
TP53 Network 1
Show member pathways
 10.95 TP53 MDM2 CDKN2A
38
Inhibition of Ribosome Biogenesis by p14(ARF) 63
10.92 TP53 MDM2 CDKN2A
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GO Terms for Malignant Spiradenoma

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Cellular components related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.77 TP53 TCHP PLIN2 PIK3CG PIK3CA PGR
2 keratin filament GO:0045095 9.43 TCHP KRT7 KRT5
3 phosphatidylinositol 3-kinase complex, class IB GO:0005944 9.16 PIK3CG PIK3CA
4 phosphatidylinositol 3-kinase complex, class IA GO:0005943 8.62 PIK3CG PIK3CA

Biological processes related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.72 TP53 PIP MTOR MDM2 CDKN2A
2 negative regulation of NF-kappaB transcription factor activity GO:0032088 9.61 CYLD CDKN2A CD200
3 cardiac septum morphogenesis GO:0060411 9.48 TP53 MDM2
4 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.46 PIK3CG PIK3CA
5 amyloid fibril formation GO:1990000 9.4 MDM2 CDKN2A
6 anoikis GO:0043276 9.37 PIK3CA MTOR
7 regulation of protein phosphorylation GO:0001932 9.33 PIK3CG PIK3CA MTOR
8 negative regulation of fibroblast apoptotic process GO:2000270 9.26 PIK3CG PIK3CA
9 cellular response to UV-C GO:0071494 8.96 TP53 MDM2
10 cellular response to actinomycin D GO:0072717 8.62 TP53 MDM2

Molecular functions related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 9.58 TP53 MDM2 CDKN2A
2 identical protein binding GO:0042802 9.56 TP53 PIP PIK3CG PGR MTOR MDM2
3 phosphatidylinositol kinase activity GO:0052742 9.48 PIK3CG PIK3CA
4 1-phosphatidylinositol-3-kinase activity GO:0016303 9.46 PIK3CG PIK3CA
5 MDM2/MDM4 family protein binding GO:0097371 9.43 TP53 CDKN2A
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.37 PIK3CG PIK3CA
7 1-phosphatidylinositol-4-phosphate 3-kinase activity GO:0035005 9.32 PIK3CG PIK3CA
8 phosphatidylinositol 3-kinase activity GO:0035004 9.26 PIK3CG PIK3CA
9 phosphatidylinositol-3,4-bisphosphate 5-kinase activity GO:0052812 9.16 PIK3CG PIK3CA
10 disordered domain specific binding GO:0097718 8.8 TP53 MDM2 CDKN2A
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Sources for Malignant Spiradenoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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