MCID: MLG036
MIFTS: 34

Malignant Spiradenoma

Categories: Rare diseases, Skin diseases, Cancer diseases

Aliases & Classifications for Malignant Spiradenoma

MalaCards integrated aliases for Malignant Spiradenoma:

Name: Malignant Spiradenoma 12 15
Malignant Eccrine Spiradenoma 12 53 73
Eccrine Spiradenoma, Malignant 53
Mes 53

Classifications:



External Ids:

Disease Ontology 12 DOID:7960
NCIt 50 C5117
SNOMED-CT 68 128895006 403942003
UMLS 73 C1266063

Summaries for Malignant Spiradenoma

NIH Rare Diseases : 53 Malignant eccrine spiradenoma is a type of tumor that develops from a sweat gland in the skin.  It starts as a rapidly-growing bump on the head or abdomen, and may cause tenderness, redness, or an open wound.  The exact cause of malignant eccrine spiradenoma is unknown, though it is thought that sun exposure or problems with the immune system (immunosuppression) may contribute to the development of this tumor.  Because malignant eccrine spiradenoma is quite rare, there are no established treatment guidelines; however, in practice, surgery is often performed to remove the tumor and additional treatments may follow, depending on the severity and extent of the cancer.

MalaCards based summary : Malignant Spiradenoma, also known as malignant eccrine spiradenoma, is related to spiradenoma and chordoma. An important gene associated with Malignant Spiradenoma is KRT5 (Keratin 5), and among its related pathways/superpathways are Platinum drug resistance and p75(NTR)-mediated signaling. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin and smooth muscle.

Related Diseases for Malignant Spiradenoma

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Malignant Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 341)
# Related Disease Score Top Affiliating Genes
1 spiradenoma 30.5 KRT7 TP53
2 chordoma 28.9 KRT7 TP53
3 papillary adenocarcinoma 28.7 CEACAM5 KRT7 TP53
4 ovarian cancer 1 27.9 CEACAM5 KRT7 PIK3CA TP53
5 gastric adenocarcinoma 27.9 CEACAM5 KRT7 PIK3CA TP53
6 breast malignant eccrine spiradenoma 12.3
7 chronic fatigue syndrome 11.6
8 meckel syndrome, type 1 11.1
9 aplastic anemia 11.0
10 hemolytic anemia 11.0
11 atrial standstill 1 10.8
12 pernicious anemia 10.8
13 fanconi anemia, complementation group a 10.8
14 hemochromatosis, type 1 10.8
15 polycythemia vera 10.8
16 sickle cell anemia 10.8
17 deficiency anemia 10.8
18 atrial fibrillation 10.8
19 long qt syndrome 10.8
20 inverted transitional papilloma 10.5 KRT5 KRT7
21 balloon cell malignant melanoma 10.5 KRT5 KRT7
22 benign breast adenomyoepithelioma 10.5 KRT5 KRT7
23 esophageal adenosquamous carcinoma 10.5 CEACAM5 KRT5
24 sensory organ benign neoplasm 10.5 KRT5 KRT7
25 middle ear adenoma 10.5 KRT5 KRT7
26 large cell acanthoma 10.5 KRT5 KRT7
27 papillary adenoma 10.5 KRT5 KRT7
28 apocrine sweat gland neoplasm 10.5 KRT5 KRT7
29 apocrine adenocarcinoma 10.5 KRT5 KRT7
30 apocrine adenoma 10.4 CEACAM5 PIK3CA
31 cervical clear cell adenocarcinoma 10.4 CEACAM5 KRT5
32 atypical choroid plexus papilloma 10.4 KRT5 KRT7
33 lymphoepithelioma-like carcinoma 10.4 KRT5 KRT7
34 lipoadenoma 10.4 KRT5 KRT7
35 nasal cavity squamous cell carcinoma 10.4 KRT5 KRT7
36 aggressive digital papillary adenocarcinoma 10.4 CEACAM5 PIK3CA
37 keratosis, seborrheic 10.4 KRT5 PIK3CA
38 cystadenofibroma 10.4 KRT5 KRT7
39 breast secretory carcinoma 10.4 KRT5 KRT7
40 adenosquamous pancreas carcinoma 10.4 KRT5 KRT7
41 hidradenoma 10.4 KRT7 PIK3CA
42 cloacogenic carcinoma 10.4 CEACAM5 KRT5
43 clear cell adenofibroma 10.4 KRT7 PIK3CA
44 cutaneous mucoepidermoid carcinoma 10.4 CEACAM5 KRT7
45 anal gland adenocarcinoma 10.4 CEACAM5 KRT7
46 vulvar intraepithelial neoplasia 10.4 KRT5 TP53
47 keratinizing squamous cell carcinoma 10.4 KRT5 TP53
48 intraneural perineurioma 10.4 KRT5 KRT7
49 sarcomatoid squamous cell skin carcinoma 10.3 KRT5 TP53
50 benign mesothelioma 10.3 KRT5 KRT7

Graphical network of the top 20 diseases related to Malignant Spiradenoma:



Diseases related to Malignant Spiradenoma

Symptoms & Phenotypes for Malignant Spiradenoma

Drugs & Therapeutics for Malignant Spiradenoma

Drugs for Malignant Spiradenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
nivolumab Approved Phase 2 946414-94-4
2 Antibodies Phase 2
3 Immunoglobulins Phase 2
4 Antibodies, Monoclonal Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Malignant Spiradenoma

Genetic Tests for Malignant Spiradenoma

Anatomical Context for Malignant Spiradenoma

MalaCards organs/tissues related to Malignant Spiradenoma:

41
Skin, Smooth Muscle

Publications for Malignant Spiradenoma

Articles related to Malignant Spiradenoma:

(show all 40)
# Title Authors Year
1
FDG PET/CT in Malignant Eccrine Spiradenoma. ( 28005641 )
2017
2
Malignant eccrine spiradenoma of the external ear. ( 26211868 )
2015
3
Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. ( 26563774 )
2015
4
Malignant Eccrine Spiradenoma of the Face. ( 26167988 )
2015
5
A malignant eccrine spiradenoma of the scalp. ( 24842352 )
2014
6
Malignant spiradenoma/cylindroma of the vulva. ( 23147883 )
2012
7
Malignant eccrine spiradenoma: a meta-analysis of reported cases. ( 20851376 )
2011
8
A rare case of giant malignant eccrine spiradenoma. ( 21342314 )
2011
9
Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. ( 19222500 )
2010
10
Malignant eccrine spiradenoma: a new case report. ( 19614990 )
2010
11
Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. ( 20483125 )
2010
12
Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. ( 20101314 )
2009
13
Direct intracranial extension of malignant eccrine spiradenoma of the face. ( 22493654 )
2009
14
Malignant eccrine spiradenoma of the scalp. ( 19098562 )
2008
15
Malignant eccrine spiradenoma. ( 17474253 )
2007
16
Malignant eccrine spiradenoma of the vulva: a case report and review of the literature. ( 16803551 )
2006
17
De novo malignant eccrine spiradenoma: a case report and review of the literature. ( 16970705 )
2006
18
Malignant eccrine spiradenoma: a case report with pulmonary metastasis. ( 14989745 )
2004
19
Low-grade malignant eccrine spiradenoma with systemic metastases. ( 12775989 )
2003
20
Malignant eccrine spiradenoma occurring on a traumatized area. ( 12087301 )
2002
21
Malignant eccrine spiradenoma: an unusual presentation. ( 17656974 )
2002
22
Malignant eccrine spiradenoma. ( 11958666 )
2002
23
Malignant eccrine spiradenoma: a case report and review of the literature. ( 11231249 )
2001
24
Malignant spiradenoma: report of two cases and literature review. ( 11174426 )
2001
25
De novo malignant eccrine spiradenoma with an interesting and unusual location. ( 11298720 )
2001
26
Malignant eccrine spiradenoma of the neck: a case report. ( 11593191 )
2001
27
Commentary on malignant eccrine spiradenoma. ( 11277909 )
2001
28
Malignant eccrine spiradenoma (spiradenocarcinoma): a clinicopathologic study of 12 cases. ( 10770427 )
2000
29
Guess what! Malignant eccrine spiradenoma. ( 10702011 )
2000
30
Malignant eccrine spiradenoma: a previously unreported presentation and review of the literature. ( 10075300 )
1999
31
Giant malignant eccrine spiradenoma of the scalp. ( 9935094 )
1999
32
Malignant eccrine spiradenoma with florid squamous differentiation. ( 9610621 )
1998
33
Malignant eccrine spiradenoma with carcinomatous and sarcomatous elements. ( 9462275 )
1997
34
Malignant eccrine spiradenoma. Case report and review of the literature. ( 9391538 )
1997
35
Malignant eccrine spiradenoma with smooth muscle cell differentiation: histological and immunohistochemical study. ( 8970199 )
1996
36
An uncommon breast tumour: the malignant eccrine spiradenoma. A case report. ( 8140844 )
1993
37
Malignant eccrine spiradenoma. A clinicopathologic study. ( 1384379 )
1992
38
Malignant eccrine spiradenoma of the hand. ( 2154644 )
1990
39
Fine needle aspiration cytology of malignant spiradenoma arising in congenital eccrine spiradenoma. ( 2157326 )
1990
40
Sweat gland carcinoma of the hand: two cases of malignant eccrine spiradenoma. ( 6096437 )
1984

Variations for Malignant Spiradenoma

Expression for Malignant Spiradenoma

Search GEO for disease gene expression data for Malignant Spiradenoma.

Pathways for Malignant Spiradenoma

Pathways related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 PIK3CA TP53
2
Show member pathways
11.08 PIK3CA TP53
3 10.98 PIK3CA TP53
4 10.77 PIK3CA TP53
5 10.36 PIK3CA TP53

GO Terms for Malignant Spiradenoma

Biological processes related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 base-excision repair GO:0006284 8.96 SMUG1 TP53
2 negative regulation of anoikis GO:2000811 8.62 CEACAM5 PIK3CA

Sources for Malignant Spiradenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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