Malignant Spiradenoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Malignant Spiradenoma

MalaCards integrated aliases for Malignant Spiradenoma:

Name: Malignant Spiradenoma ¹¹ ¹⁴

Malignant Eccrine Spiradenoma ¹¹ ¹⁹ ⁷¹

Eccrine Spiradenoma, Malignant ¹⁹

Mes ¹⁹

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:7960

NCIt ⁴⁹ C5117

SNOMED-CT ⁶⁸ 403942003

UMLS ⁷¹ C1266063

Sources

Summaries for Malignant Spiradenoma

GARD: ¹⁹ Malignant eccrine spiradenoma is a type of tumor that develops from a sweat gland in the skin. It starts as a rapidly-growing bump on the head or abdomen, and may cause tenderness, redness, or an open wound. The exact cause of Malignant eccrine spiradenoma is unknown, though it is thought that sun exposure or problems with the immune system (immunosuppression) may contribute to the development of this tumor.

MalaCards based summary: Malignant Spiradenoma, also known as malignant eccrine spiradenoma, is related to adenoid cystic carcinoma and skin benign neoplasm. An important gene associated with Malignant Spiradenoma is CYLD (CYLD Lysine 63 Deubiquitinase), and among its related pathways/superpathways are Ovarian tumor domain proteases and LKB1 signaling events. Affiliated tissues include skin, lymph node and smooth muscle, and related phenotype is digestive/alimentary.

Sources

Related Diseases for Malignant Spiradenoma

Diseases in the Spiradenoma family:

Malignant Spiradenoma

Diseases related to Malignant Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 483)

#	Related Disease	Score	Top Affiliating Genes
1	adenoid cystic carcinoma	29.9	TP53 KRT7 CYLD
2	skin benign neoplasm	29.6	TP53 PIP KRT7 KRT5 CYLD
3	colon adenocarcinoma	29.5	TP53 ESR1 CEACAM5
4	spiradenoma	29.3	PIP KRT7 KRT5 CYLD CEACAM5
5	colorectal adenocarcinoma	29.3	TP53 KRT7 CEACAM5
6	sweat gland benign neoplasm	29.2	TP53 PIP KRT7 KRT5 CYLD CEACAM5
7	salivary gland adenoid cystic carcinoma	29.1	TP53 PIP KRT7 KRT5 CYLD
8	sweat gland cancer	28.6	TP53 PIP KRT7 KRT5 ESR1 CEACAM5
9	breast malignant eccrine spiradenoma	11.5
10	meckel syndrome, type 1	11.1
11	uterine corpus sarcoma	10.5
12	uterine sarcoma	10.5
13	sarcoma	10.5
14	fanconi anemia, complementation group e	10.3
15	carcinosarcoma	10.3
16	hypereosinophilic syndrome	10.2
17	squamous cell carcinoma	10.2
18	bartholin's gland adenoid cystic carcinoma	10.2	KRT7 CYLD
19	anal canal paget's disease	10.2	PIP KRT7
20	anal gland adenocarcinoma	10.2	PIP KRT7
21	bartholin's gland adenocarcinoma	10.2	PIP KRT7
22	anus adenocarcinoma	10.2	PIP KRT7
23	anal canal adenocarcinoma	10.2	PIP KRT7
24	gastric signet ring cell adenocarcinoma	10.2	PIP KRT7
25	adenofibroma	10.2	TP53 KRT7
26	bile duct adenoma	10.1	TP53 KRT7
27	eyelid carcinoma	10.1	PIP KRT7
28	47 xxx syndrome	10.1
29	meibomian cyst	10.1	PIP KRT7
30	erysipeloid	10.1	PIP KRT7
31	bartholin's gland disease	10.1	PIP KRT7
32	ovarian mesodermal adenosarcoma	10.1	KRT7 ESR1
33	atrophic vulva	10.1	KRT7 ESR1
34	mixed lacrimal gland cancer	10.1	PIP KRT7
35	breast cancer	10.1
36	posttransplant acute limbic encephalitis	10.1
37	breast hemangioma	10.1	TP53 KRT7
38	vaginal carcinosarcoma	10.1	TP53 KRT7
39	intratubular embryonal carcinoma	10.1	TP53 KRT7
40	basosquamous carcinoma	10.1	TP53 KRT7
41	ureteral benign neoplasm	10.1	TP53 KRT7
42	ovarian seromucinous carcinoma	10.1	KRT7 ESR1
43	papillary transitional carcinoma	10.1	TP53 KRT7
44	squamous cell papilloma	10.1	TP53 KRT7
45	cystadenofibroma	10.1	TP53 KRT7
46	bladder transitional cell papilloma	10.1	TP53 KRT7
47	breast adenomyoepithelioma	10.1	KRT7 KRT5
48	glandular cystitis	10.1	TP53 KRT7
49	brooke-spiegler syndrome	10.1	KRT7 CYLD
50	ovarian serous cystadenofibroma	10.1	TP53 KRT7

Graphical network of the top 20 diseases related to Malignant Spiradenoma:

Sources

Symptoms & Phenotypes for Malignant Spiradenoma

MGI Mouse Phenotypes related to Malignant Spiradenoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	digestive/alimentary	MP:0005381	9.1	CEACAM5 CYLD ESR1 KRT5 PIP TP53

Sources

Drugs & Therapeutics for Malignant Spiradenoma

Search Clinical Trials, NIH Clinical Center for Malignant Spiradenoma

Sources

Genetic Tests for Malignant Spiradenoma

Sources

Anatomical Context for Malignant Spiradenoma

Organs/tissues related to Malignant Spiradenoma:

MalaCards : Skin, Lymph Node, Smooth Muscle, Breast

Sources

Publications for Malignant Spiradenoma

Articles related to Malignant Spiradenoma:

(show top 50) (show all 58)

#	Title	Authors	PMID	Year
1	Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review. ⁶²	Kibe Y...Saito R	35717180	2022
2	Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review. ⁶²	Wagner K...Serpell J	33522696	2021
3	A rare case of malignant eccrine spiradenoma mimicking carcinosarcoma. ⁶²	Kundu A...Mahapatra AS	33851645	2021
4	Malignant Eccrine Adenoma With Sarcomatous (Heterologous) Components: Report of a Rare Skin Adnexal Neoplasm With Literature Review. ⁶²	Ishtiaq H...Fatima S	33532153	2020
5	Low grade malignant eccrine spiradenoma of the vulva: case report, review of the literature and discussion about the role of p53 and HPV. ⁶²	Catteau X...Noel JC	32169099	2020
6	Malignant Eccrine Spiradenoma of the External Auditory Canal: A Case Report and Literature Review. ⁶²	You D...Dong W	33469512	2020
7	[Malignant transformation of an eccrine spiradenoma]. ⁶²	Jacquemus J...Balme B	28277254	2017
8	FDG PET/CT in Malignant Eccrine Spiradenoma. ⁶²	Sanchez Petitto G...Bhattacharjee M	28005641	2017
9	Malignant Spiradenoma: a Giant Cutaneous Adnexal Tumor. ⁶²	Ruiz-Gonzalez JF...Solis-Ledezma G	26563774	2016
10	Zosteriform configuration of multiple eccrine spiradenomas of the scalp. ⁶²	Sorin T...Simon E	25555434	2016
11	Skin spiradenocarcinoma - case presentation. ⁶²	Rebegea LF...Patrascu A	27151731	2016
12	Malignant Eccrine Spiradenoma of the Face. ⁶²	Nyame TT...Caterson EJ	26167988	2015
13	Malignant eccrine spiradenoma of the external ear. ⁶²	Bicer YO...Yilmaz F	26211868	2015
14	A malignant eccrine spiradenoma of the scalp. ⁶²	Chow W...Griffiths M	24842352	2014
15	Malignant spiradenoma/cylindroma of the vulva. ⁶²	Emam EE...Molah RM	23147883	2012
16	Apocrine-eccrine carcinomas: molecular and immunohistochemical analyses. ⁶²	Le LP...Hoang MP	23056620	2012
17	Rare tumors through the looking glass: an examination of malignant cutaneous adnexal tumors. ⁶²	Martinez SR...Canter RJ	21931043	2011
18	Malignant eccrine spiradenoma: a meta-analysis of reported cases. ⁶²	Andreoli MT...Itani KM	20851376	2011
19	A rare case of giant malignant eccrine spiradenoma. ⁶²	Ascari-Raccagni A...Trevisan G	21342314	2011
20	Not all stubbed toes are innocuous--A case report of rare malignant eccrine spiradenoma (spiradenocarcinoma) of the toe. ⁶²	Jariwala A...McLeod G	20483125	2010
21	Malignant eccrine spiradenoma: a new case report. ⁶²	Ben Brahim E...Chatti S	19614990	2010
22	Malignant eccrine spiradenoma: case report and review of the literature, including 15 Japanese cases. ⁶²	Tanese K...Ishiko A	19222500	2010
23	Direct intracranial extension of malignant eccrine spiradenoma of the face. ⁶²	Pedamallu SB...Al-Zwae K	22493654	2009
24	Malignant eccrine spiradenoma on the lateral margin of nose as an infrequent localization. ⁶²	Bercin S...Suren D	20101314	2009
25	Malignant eccrine spiradenoma of the scalp. ⁶²	Seyhan T...Bal N	19098562	2008
26	A case of malignant eccrine spiradenoma metastatic to intramammary lymph node. ⁶²	Tanaka Y...Shibata T	18270794	2008
27	Malignant eccrine spiradenoma. ⁶²	Mardi K...Sharma J	17474253	2007
28	De novo malignant eccrine spiradenoma: a case report and review of the literature. ⁶²	Hantash BM...Gladstone HB	16970705	2006
29	Malignant eccrine spiradenoma of the vulva: a case report and review of the literature. ⁶²	Chase DM...Berman ML	16803551	2006
30	Malignant eccrine spiradenoma: a case report with pulmonary metastasis. ⁶²	Chou SC...Tseng HH	14989745	2004
31	Low-grade malignant eccrine spiradenoma with systemic metastases. ⁶²	Leonard N...McNamara P	12775989	2003
32	Linear spiradenoma with focal malignant transformation. ⁶²	Braun-Falco M...Hein R	12702073	2003
33	Malignant eccrine spiradenoma: an unusual presentation. ⁶²	Agarwal S...Khanna AK	17656974	2002
34	Malignant eccrine spiradenoma occurring on a traumatized area. ⁶²	Arslan E...Cin I	12087301	2002
35	Malignant eccrine spiradenoma. ⁶²	Mirza I...Sieber SC	11958666	2002
36	[Eccrine spiradenocarcinoma with unusual histiocytic giant cell components. Case report and review of the literature of a rare sweat gland tumor]. ⁶²	Roetman B...Krismann M	12001532	2002
37	Malignant eccrine spiradenoma of the neck: a case report. ⁶²	Otero-Garcia JE...Trinidad-Pinedo J	11593191	2001
38	De novo malignant eccrine spiradenoma with an interesting and unusual location. ⁶²	Yildirim S...Ege GA	11298720	2001
39	Commentary on malignant eccrine spiradenoma. ⁶²	Ratner D	11277909	2001
40	Malignant spiradenoma: report of two cases and literature review. ⁶²	Fernandez-Acenero MJ...Requena L	11174426	2001
41	Malignant eccrine spiradenoma: a case report and review of the literature. ⁶²	Ishikawa M...Yamamoto A	11231249	2001
42	Malignant eccrine spiradenoma (spiradenocarcinoma): a clinicopathologic study of 12 cases. ⁶²	Granter SR...McKee PH	10770427	2000
43	Guess what! Malignant eccrine spiradenoma. ⁶²	Sonmez Ergun S...Buyukbabani N	10702011	2000
44	Malignant eccrine spiradenoma: a previously unreported presentation and review of the literature. ⁶²	Beekley AC...Porter C	10075300	1999
45	Giant malignant eccrine spiradenoma of the scalp. ⁶²	Jamshidi M...Fatteh SM	9935094	1999
46	Malignant eccrine spiradenoma with florid squamous differentiation. ⁶²	Lee HH...Lee KG	9610621	1998
47	Malignant eccrine spiradenoma. Case report and review of the literature. ⁶²	Tay JS...Solari PG	9391538	1997
48	Malignant eccrine spiradenoma with carcinomatous and sarcomatous elements. ⁶²	McCluggage WG...Allen DC	9462275	1997
49	Malignant eccrine spiradenoma with smooth muscle cell differentiation: histological and immunohistochemical study. ⁶²	Itoh T...Tokunaga M	8970199	1996
50	Carcinosarcoma arising in eccrine spiradenoma of the breast. Report of a case and review of the literature. ⁶²	Saboorian MH...Albores-Saavedra J	8639057	1996

Sources

Genes for Malignant Spiradenoma

Genes related to Malignant Spiradenoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CYLD	CYLD Lysine 63 Deubiquitinase	Protein Coding	5.4	DISEASES inferred ¹⁴
2	KRT7	Keratin 7	Protein Coding	5.39	DISEASES inferred ¹⁴
3	PIP	Prolactin Induced Protein	Protein Coding	5.14	DISEASES inferred ¹⁴
4	TP53	Tumor Protein P53	Protein Coding	4.72	DISEASES inferred ¹⁴
5	KRT5	Keratin 5	Protein Coding	4.54	DISEASES inferred ¹⁴
6	CEACAM5	CEA Cell Adhesion Molecule 5	Protein Coding	4.32	DISEASES inferred ¹⁴
7	ESR1	Estrogen Receptor 1	Protein Coding	3.96	DISEASES inferred ¹⁴

Sources

Variations for Malignant Spiradenoma

Sources

Expression for Malignant Spiradenoma

Search GEO for disease gene expression data for Malignant Spiradenoma.

Sources

Pathways for Malignant Spiradenoma

Pathways related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Ovarian tumor domain proteases ⁶⁶	10.75	TP53 ESR1
2	LKB1 signaling events ⁶¹	10.52	TP53 ESR1
3	Signaling mediated by p38-alpha and p38-beta ⁶¹	10.14	TP53 ESR1

Sources

GO Terms for Malignant Spiradenoma

Biological processes related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	necroptotic process	GO:0070266	9.46	TP53 CYLD
2	negative regulation of miRNA maturation	GO:1903799	9.13	TP53 ESR1
3	positive regulation of RNA polymerase II transcription preinitiation complex assembly	GO:0045899	8.92	TP53 ESR1

Sources

Sources for Malignant Spiradenoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MES MCID: MLG036 MIFTS: 29	Malignant Spiradenoma (MES) Categories: Cancer diseases, Endocrine diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Expand all tables

Malignant Spiradenoma (MES)

Aliases & Classifications for Malignant Spiradenoma

MalaCards integrated aliases for Malignant Spiradenoma:

Classifications:

External Ids:

Summaries for Malignant Spiradenoma

Related Diseases for Malignant Spiradenoma

Diseases in the Spiradenoma family:

Diseases related to Malignant Spiradenoma via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Malignant Spiradenoma:

Symptoms & Phenotypes for Malignant Spiradenoma

MGI Mouse Phenotypes related to Malignant Spiradenoma:

Drugs & Therapeutics for Malignant Spiradenoma

Genetic Tests for Malignant Spiradenoma

Anatomical Context for Malignant Spiradenoma

Organs/tissues related to Malignant Spiradenoma:

Publications for Malignant Spiradenoma

Articles related to Malignant Spiradenoma:

Genes for Malignant Spiradenoma

Genes related to Malignant Spiradenoma (0 elite genes):

Variations for Malignant Spiradenoma

Expression for Malignant Spiradenoma

Pathways for Malignant Spiradenoma

Pathways related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

GO Terms for Malignant Spiradenoma

Biological processes related to Malignant Spiradenoma according to GeneCards Suite gene sharing:

Sources for Malignant Spiradenoma