MCID: MLG059
MIFTS: 40

Malignant Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Malignant Struma Ovarii

MalaCards integrated aliases for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 12 15
Struma Ovarii, Malignant 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5208
NCIt 50 C4291
SNOMED-CT 68 18854008
UMLS 73 C0334525

Summaries for Malignant Struma Ovarii

Disease Ontology : 12 A struma ovarii that is cancerous.

MalaCards based summary : Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to struma ovarii and ovarian germ cell teratoma. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hormones, Hormone Substitutes, and Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, liver and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Malignant Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 struma ovarii 31.8 NKX2-1 RET TG
2 ovarian germ cell teratoma 30.2 NKX2-1 NRAS RET TG
3 papillary carcinoma 29.6 KRT19 LGALS3 NCOA4 NKX2-1 RET TG
4 thyroid cancer, nonmedullary, 2 29.4 HRAS KRT19 LGALS3 NKX2-1 NRAS RET
5 thyroid cancer 29.0 HRAS KRT19 LGALS3 NCOA4 NKX2-1 NRAS
6 graves' disease 10.4
7 thyroid cancer, nonmedullary, 1 10.3
8 teratoma 10.3
9 giant congenital nevus 10.2 HRAS NRAS
10 schimmelpenning-feuerstein-mims syndrome 10.2 HRAS NRAS
11 ovarian melanoma 10.2 HRAS NRAS
12 malignant conjunctival melanoma 10.2 HRAS NRAS
13 melanomatosis 10.2 HRAS NRAS
14 marcus gunn phenomenon 10.2 HRAS NRAS
15 athyreosis 10.2 NKX2-1 TG
16 nodular malignant melanoma 10.2 HRAS NRAS
17 adenocarcinoma 10.2
18 thyroiditis 10.2
19 pseudo-meigs syndrome 10.2
20 myelodysplastic myeloproliferative cancer 10.2 HRAS NRAS
21 meningeal melanomatosis 10.2 HRAS NRAS
22 melanocytic nevus syndrome, congenital 10.2 HRAS NRAS
23 acneiform dermatitis 10.2 HRAS NRAS
24 chromosome 14q11-q22 deletion syndrome 10.2 HRAS NKX2-1
25 lung adenoid cystic carcinoma 10.2 HRAS NKX2-1
26 vulvar melanoma 10.1 HRAS NRAS
27 papillary thyroid microcarcinoma 10.1 NKX2-1 TG
28 ovarian cystic teratoma 10.1 NKX2-1 TG
29 sporadic pheochromocytoma 10.1 HRAS RET
30 malignant skin fibrous histiocytoma 10.1 HRAS NRAS
31 core binding factor acute myeloid leukemia 10.1 HRAS NRAS
32 anal canal adenocarcinoma 10.1 HRAS KRT19
33 malignant dermis tumor 10.1 HRAS NRAS
34 mature teratoma 10.1 AFP TG
35 biliary papillomatosis 10.1 HRAS KRT19
36 mucinous bronchioloalveolar adenocarcinoma 10.1 LGALS3 NKX2-1
37 colloid carcinoma of the pancreas 10.1 HRAS KRT19
38 adenosquamous lung carcinoma 10.1 HRAS RET
39 hypothyroidism 10.1 NKX2-1 RET TG
40 cystadenofibroma 10.1 AFP TG
41 thyroid carcinoma, familial medullary 10.1 NKX2-1 RET TG
42 central nervous system melanocytic neoplasm 10.1 HRAS NRAS
43 rete testis adenocarcinoma 10.1 AFP NKX2-1
44 multinodular goiter 10.1 HRAS NKX2-1 TG
45 adenomatoid tumor 10.0 AFP NKX2-1
46 rete testis neoplasm 10.0 AFP NKX2-1
47 intrahepatic bile duct adenoma 10.0 AFP KRT19
48 nodular goiter 10.0 LGALS3 RET TG
49 renal pelvis adenocarcinoma 10.0 AFP KRT19
50 brachydactyly, type e1 10.0 KRT19 PTCH1

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to Malignant Struma Ovarii

Symptoms & Phenotypes for Malignant Struma Ovarii

GenomeRNAi Phenotypes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.4 NRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.4 RET
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.4 NRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.4 RET
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.4 HRAS NRAS RET
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.4 RET
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 HRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 NRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 HRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.4 HRAS

MGI Mouse Phenotypes related to Malignant Struma Ovarii:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.11 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
2 homeostasis/metabolism MP:0005376 10.11 AFP HRAS LGALS3 NCOA4 NKX2-1 NRAS
3 endocrine/exocrine gland MP:0005379 10.1 AFP HRAS KRT19 NKX2-1 NRAS PTCH1
4 behavior/neurological MP:0005386 10.09 AFP HRAS LGALS3 NKX2-1 NRAS PTCH1
5 cardiovascular system MP:0005385 10.08 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
6 growth/size/body region MP:0005378 10.08 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
7 cellular MP:0005384 10.07 KRT19 LGALS3 NCOA4 NKX2-1 NRAS PTCH1
8 mortality/aging MP:0010768 10.03 AFP HRAS KRT19 LGALS3 NKX2-1 NRAS
9 neoplasm MP:0002006 10.01 AFP HRAS KRT19 LGALS3 NKX2-1 NRAS
10 nervous system MP:0003631 9.91 HRAS KRT19 LGALS3 NKX2-1 PTCH1 RET
11 no phenotypic analysis MP:0003012 9.8 HRAS KRT19 NKX2-1 NRAS PTCH1 RET
12 normal MP:0002873 9.73 HRAS KRT19 NKX2-1 NRAS PTCH1 RET
13 reproductive system MP:0005389 9.63 AFP KRT19 LGALS3 NKX2-1 PTCH1 RET
14 respiratory system MP:0005388 9.35 HRAS LGALS3 NKX2-1 PTCH1 RET
15 skeleton MP:0005390 9.17 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1

Drugs & Therapeutics for Malignant Struma Ovarii

Drugs for Malignant Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones, Hormone Substitutes, and Hormone Antagonists
2 Hormones
3 Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

Anatomical Context for Malignant Struma Ovarii

MalaCards organs/tissues related to Malignant Struma Ovarii:

41
Thyroid, Liver, Lung, Brain, Kidney, Pancreas, Testis

Publications for Malignant Struma Ovarii

Articles related to Malignant Struma Ovarii:

(show top 50) (show all 91)
# Title Authors Year
1
Erratum: Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii. ( 29794490 )
2018
2
Rare Clinical Entity: Metastatic malignant struma ovarii diagnosed during pregnancy - Lessons for management. ( 29946481 )
2018
3
Complete Remission After Single Radioiodine Therapy in Malignant Struma Ovarii With Bone and Lymph Node Metastases. ( 30394923 )
2018
4
The Smallest Reported Malignant Struma Ovarii: A Case Report. ( 30483100 )
2018
5
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. ( 29278520 )
2017
6
Metastatic malignant struma ovarii: Two scenarios of the same pathology. ( 28440778 )
2017
7
Malignant Struma ovarii in a 30-year old nulliparous patient. ( 28572843 )
2017
8
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. ( 28982046 )
2017
9
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. ( 29286966 )
2017
10
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
11
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
12
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
13
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
14
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
15
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
16
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
17
Malignant struma ovarii with insular carcinoma: A case report and literature review. ( 29607388 )
2016
18
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
19
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2015
20
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. ( 26262453 )
2015
21
The lack of consensus in management of malignant struma ovarii. ( 25539066 )
2014
22
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. ( 25375817 )
2014
23
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. ( 24152665 )
2014
24
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. ( 25364407 )
2014
25
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. ( 25474425 )
2014
26
Two cases of malignant struma ovarii with metastasis to pelvic bone. ( 23391779 )
2013
27
Synchronous papillary carcinoma thyroid with malignant struma ovarii: A management dilemma. ( 24379539 )
2013
28
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. ( 24217901 )
2013
29
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. ( 22883659 )
2012
30
Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. ( 22288964 )
2012
31
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. ( 21531638 )
2011
32
Malignant struma ovarii complicated by Trousseau's syndrome and repeated episodes of cerebral ischemic strokes: A case report. ( 24371609 )
2011
33
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. ( 21934226 )
2011
34
Metastatic malignant struma ovarii. ( 21598816 )
2011
35
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment. ( 21269611 )
2011
36
Malignant struma ovarii. ( 20375218 )
2010
37
Metastasis of malignant struma ovarii to the lumbar spine. ( 20036545 )
2010
38
Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread. ( 20407319 )
2010
39
Malignant struma ovarii: a case report. ( 20119594 )
2010
40
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. ( 19772400 )
2009
41
Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. ( 19696610 )
2009
42
Malignant struma ovarii: good response after thyroidectomy and I ablation therapy. ( 21892277 )
2008
43
Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. ( 18496456 )
2008
44
Malignant struma ovarii. ( 18560398 )
2008
45
An unusual variant of malignant struma ovarii. ( 18678124 )
2008
46
Malignant struma ovarii--a case report and review of the literature. ( 17890867 )
2008
47
Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. ( 17882443 )
2008
48
Malignant struma ovarii: a case report and review of the literature. ( 17646728 )
2007
49
BRAF T1799A mutation occurring in a case of malignant struma ovarii. ( 17478764 )
2007
50
Malignant struma ovarii mimic clear cell carcinoma. ( 14986024 )
2005

Variations for Malignant Struma Ovarii

Expression for Malignant Struma Ovarii

Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for Malignant Struma Ovarii

Pathways related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 HRAS NCOA4 NRAS RET
2 12.07 HRAS NCOA4 NRAS PTCH1 RET
3 12 HRAS NRAS PTCH1
4 11.9 HRAS NRAS PTCH1
5
Show member pathways
11.8 HRAS NRAS RET
6
Show member pathways
11.35 HRAS NRAS RET
7 11.25 AFP NKX2-1
8 11.22 HRAS NRAS
9 11.16 HRAS RET
10 11.16 HRAS RET
11 11.14 HRAS NRAS RET
12 11.1 HRAS NRAS
13 11.03 HRAS NRAS
14 11.02 HRAS NRAS
15
Show member pathways
11 HRAS NRAS
16
Show member pathways
10.93 HRAS NRAS
17 10.82 HRAS NRAS
18 10.78 HRAS NRAS
19 10.67 HRAS NRAS
20 10.48 HRAS NRAS RET
21 10.44 HRAS NRAS
22 10.06 HRAS RET

GO Terms for Malignant Struma Ovarii

Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.46 NCOA4 NKX2-1 PTCH1 RET
2 MAPK cascade GO:0000165 9.43 HRAS NRAS RET
3 thyroid gland development GO:0030878 8.96 NKX2-1 TG
4 animal organ morphogenesis GO:0009887 8.8 HRAS NKX2-1 PTCH1

Sources for Malignant Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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