MCID: MLG059
MIFTS: 29

Malignant Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Malignant Struma Ovarii

MalaCards integrated aliases for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 12 15
Struma Ovarii, Malignant 12 71

Classifications:



External Ids:

Disease Ontology 12 DOID:5208
NCIt 49 C4291
SNOMED-CT 67 18854008
UMLS 71 C0334525

Summaries for Malignant Struma Ovarii

Disease Ontology : 12 A struma ovarii that is cancerous.

MalaCards based summary : Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to thyroid cancer, nonmedullary, 2 and papillary adenocarcinoma. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin). The drugs Iodine and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and ovary, and related phenotypes are digestive/alimentary and neoplasm

Related Diseases for Malignant Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 thyroid cancer, nonmedullary, 2 30.5 TG LGALS3
2 papillary adenocarcinoma 30.3 NKX2-1 KRT19
3 ovarian germ cell cancer 30.0 TG NKX2-1 NCOA4
4 thyroid tumor 29.9 TG RET LGALS3
5 struma ovarii 29.8 TG RET NKX2-1 NCOA4 KRT19
6 thyroid carcinoma 29.8 TG RET NKX2-1 NCOA4 LGALS3
7 differentiated thyroid carcinoma 29.6 TG RET NKX2-1 NCOA4
8 thyroiditis 29.2 TG RET NKX2-1 NCOA4
9 follicular adenoma 28.7 TG RET NKX2-1 LGALS3 KRT19
10 thyroid gland disease 28.7 TG RET NKX2-1 NCOA4 LGALS3
11 thyroid gland papillary carcinoma 28.6 TG RET NKX2-1 NCOA4 LGALS3 KRT19
12 ovarian germ cell teratoma 28.6 TG RET NKX2-1 NCOA4 LGALS3 KRT19
13 benign struma ovarii 28.5 TG RET NKX2-1 NCOA4 KRT19
14 papillary carcinoma 28.5 TG RET NKX2-1 NCOA4 LGALS3 KRT19
15 hashimoto thyroiditis 28.3 TG RET NCOA4 LGALS3 KRT19
16 thyroid gland follicular carcinoma 28.0 TG RET NKX2-1 NCOA4 LGALS3 KRT19
17 teratoma 10.9
18 thyroid cancer, nonmedullary, 1 10.8
19 teratoma, ovarian 10.8
20 rare tumor 10.7
21 hyperthyroidism 10.6
22 germ cells tumors 10.6
23 graves disease 1 10.5
24 cystic teratoma 10.5
25 ovarian cancer 10.4
26 graves' disease 10.4
27 ovarian cyst 10.3
28 adenoma 10.3
29 pseudo-meigs syndrome 10.3
30 sarcoidosis 1 10.2
31 pulmonary disease, chronic obstructive 10.2
32 salivary gland carcinoma 10.2
33 bone disease 10.2
34 respiratory failure 10.2
35 constipation 10.2
36 adenocarcinoma 10.2
37 germ cell cancer 10.2
38 serous cystadenocarcinoma 10.2
39 ovarian cystic teratoma 10.2
40 mature teratoma 10.2
41 bronchiectasis 10.2
42 dysphagia 10.2
43 tremor 10.2
44 multicentric papillary thyroid carcinoma 10.2 TG RET
45 atypical follicular adenoma 10.1 TG RET
46 nonencapsulated sclerosing carcinoma 10.1 TG RET
47 colloid adenoma 10.1 TG LGALS3
48 parathyroid gland disease 10.1 TG RET
49 athyreosis 10.1 TG NKX2-1
50 autoimmune disease of endocrine system 10.1 TG RET

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to Malignant Struma Ovarii

Symptoms & Phenotypes for Malignant Struma Ovarii

MGI Mouse Phenotypes related to Malignant Struma Ovarii:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.55 KRT19 LGALS3 NKX2-1 RET TG
2 neoplasm MP:0002006 9.26 KRT19 LGALS3 NKX2-1 RET
3 respiratory system MP:0005388 8.92 KRT19 LGALS3 NKX2-1 RET

Drugs & Therapeutics for Malignant Struma Ovarii

Drugs for Malignant Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2 Hormone Antagonists
3 Hormones
4 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pharmacokinetic and Pharmacodynamic Studies of Liothyronine. A Study on the Metabolic Effects of Thyroid Hormone Completed NCT01441154

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

Anatomical Context for Malignant Struma Ovarii

MalaCards organs/tissues related to Malignant Struma Ovarii:

40
Thyroid, Bone, Ovary, Liver, Eye, Lymph Node, Thymus

Publications for Malignant Struma Ovarii

Articles related to Malignant Struma Ovarii:

(show top 50) (show all 149)
# Title Authors PMID Year
1
Papillary Thyroid Cancer in a Struma Ovarii in a 17-Year-Old Nulliparous Patient: A case Report. 61
31952290 2020
2
Struma ovarii with atypical features and synchronous primary thyroid cancer: a case report and review of the literature. 61
31679038 2019
3
Malignant struma ovarii presenting with follicular carcinoma: A case report with molecular analysis. 61
31538107 2019
4
Complete Remission After Single Radioiodine Therapy in Malignant Struma Ovarii With Bone and Lymph Node Metastases. 61
30394923 2019
5
Unusual Case of Malignant Struma Ovarii and Cervical Thyroid Cancer Preceded by Ovarian Teratoma: Case Report and Review of the Literature. 61
31007958 2019
6
Extensive peritoneal implant metastases of malignant struma ovarii treated by thyroidectomy and 131I therapy: A case report. 61
30572559 2018
7
The Smallest Reported Malignant Struma Ovarii: A Case Report. 61
30483100 2018
8
Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations. 61
30087949 2018
9
Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. 61
29318892 2018
10
Erratum: Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii. 61
29794490 2018
11
An unusual presentation of a papillary thyroid carcinoma in the struma ovarii in a 10 year-old girl: A case report. 61
30196119 2018
12
The largest reported papillary thyroid carcinoma arising in struma ovarii and metastasis to opposite ovary: case report and review of literature. 61
30061934 2018
13
Rare Clinical Entity: Metastatic malignant struma ovarii diagnosed during pregnancy - Lessons for management. 61
29946481 2018
14
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. 61
29286966 2017
15
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. 61
29278520 2017
16
Metastatic malignant struma ovarii: Two scenarios of the same pathology. 61
28440778 2017
17
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. 61
28982046 2017
18
Malignant Struma ovarii in a 30-year old nulliparous patient. 61
28572843 2017
19
Malignant struma ovarii with insular carcinoma: A case report and literature review. 61
29607388 2016
20
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. 61
27843812 2016
21
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. 61
27566096 2016
22
Management dilemma of thyroid nodules in patients with malignant struma ovarii. 61
27563566 2016
23
Sincronous malignant struma ovarii and papillary thyroid carcinoma. 61
27297016 2016
24
Treatment and follow-up of malignant struma ovarii: Regarding two cases. 61
27355004 2016
25
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. 61
26630220 2016
26
[Benign struma ovarii: Report of 7 cases and review of the literature]. 61
26997461 2016
27
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. 61
27224256 2016
28
A Hormonally Active Malignant Struma Ovarii. 61
27882257 2016
29
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. 61
26791568 2016
30
Papillary Carcinoma in Mature Teratoma of Struma Ovarii. 61
30039072 2015
31
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. 61
26262453 2015
32
Late Manifestation of Struma Peritonei and Widespread Functioning Lesions in the Setting of Struma Ovarii Simulating Highly Differentiated Follicular Carcinoma. 61
25537757 2015
33
Sonographic and Pathologic Features of Struma Ovarii. 61
26149143 2015
34
Follicular proliferative lesion arising in struma ovarii. 61
26018519 2015
35
The lack of consensus in management of malignant struma ovarii. 61
25539066 2015
36
Spinal metastasis from struma ovarii: case report and review of the literature. 61
25901242 2015
37
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. 61
25375817 2015
38
A case report of thyroid carcinoma confined to ovary and concurrently occult in the thyroid: is conservative treatment always advised? 61
25745492 2015
39
Hashimoto thyroiditis onset after laparoscopic removal of struma ovarii: an overview to unravel a rare and intriguing finding. 61
26524822 2015
40
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. 61
25364407 2014
41
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. 61
25474425 2014
42
[Clinical study on 68 cases with struma ovarii]. 61
25169639 2014
43
Struma ovarii: role of imaging? 61
24357453 2014
44
131I therapy using rhTSH stimulation and dosimetry in metastatic malignant struma ovarii. 61
24152665 2014
45
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. 61
24217901 2013
46
Synchronous papillary carcinoma thyroid with malignant struma ovarii: A management dilemma. 61
24379539 2013
47
Two cases of malignant struma ovarii with metastasis to pelvic bone. 61
23391779 2013
48
Struma ovarii maligna. 61
23645304 2013
49
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. 61
22883659 2012
50
Papillary thyroid cancer arising in struma ovarii. 61
22369392 2012

Variations for Malignant Struma Ovarii

Expression for Malignant Struma Ovarii

Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for Malignant Struma Ovarii

GO Terms for Malignant Struma Ovarii

Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.33 RET NKX2-1 NCOA4
2 response to hormone GO:0009725 8.96 NKX2-1 NCOA4
3 thyroid gland development GO:0030878 8.62 TG NKX2-1

Sources for Malignant Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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