MCID: MLG059
MIFTS: 36

Malignant Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Malignant Struma Ovarii

MalaCards integrated aliases for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 12 15
Struma Ovarii, Malignant 12 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5208
NCIt 50 C4291
SNOMED-CT 68 18854008
UMLS 72 C0334525

Summaries for Malignant Struma Ovarii

Disease Ontology : 12 A struma ovarii that is cancerous.

MalaCards based summary : Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to struma ovarii and ovarian germ cell teratoma. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hormones and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid, ovary and liver, and related phenotypes are digestive/alimentary and homeostasis/metabolism

Related Diseases for Malignant Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 struma ovarii 32.1 TG RET NKX2-1
2 ovarian germ cell teratoma 31.0 TG RET NRAS NKX2-1
3 ovarian cystic teratoma 30.8 TG NKX2-1
4 mature teratoma 30.6 TG AFP
5 benign struma ovarii 30.4 TG RET NRAS HRAS
6 ovarian germ cell cancer 29.9 TG RET NKX2-1 AFP
7 hashimoto thyroiditis 29.6 TG RET LGALS3 KRT19
8 follicular adenoma 29.3 TG RET NKX2-1 LGALS3 KRT19
9 differentiated thyroid carcinoma 28.8 TG RET NRAS NKX2-1 NCOA4 HRAS
10 papillary carcinoma 28.7 TG RET NKX2-1 NCOA4 LGALS3 KRT19
11 thyroid cancer, nonmedullary, 2 28.1 TG RET NRAS NKX2-1 LGALS3 KRT19
12 thyroid gland disease 28.0 TG RET PTCH1 NKX2-1 NCOA4 LGALS3
13 thyroid carcinoma 11.0
14 teratoma 10.9
15 teratoma, ovarian 10.8
16 thyroid cancer, nonmedullary, 1 10.8
17 thyroid gland papillary carcinoma 10.8
18 rare tumor 10.7
19 hyperthyroidism 10.6
20 germ cells tumors 10.6
21 graves disease 1 10.5
22 cystic teratoma 10.5
23 papillary adenocarcinoma 10.5
24 giant congenital nevus 10.5 NRAS HRAS
25 schimmelpenning-feuerstein-mims syndrome 10.5 NRAS HRAS
26 ovarian melanoma 10.5 NRAS HRAS
27 melanomatosis 10.5 NRAS HRAS
28 malignant conjunctival melanoma 10.5 NRAS HRAS
29 athyreosis 10.5 TG NKX2-1
30 marcus gunn phenomenon 10.4 NRAS HRAS
31 nodular malignant melanoma 10.4 NRAS HRAS
32 ovarian cancer 10.4
33 graves' disease 10.4
34 meningeal melanomatosis 10.4 NRAS HRAS
35 melanocytic nevus syndrome, congenital 10.4 NRAS HRAS
36 chromosome 14q11-q22 deletion syndrome 10.4 NKX2-1 HRAS
37 acneiform dermatitis 10.4 NRAS HRAS
38 lung adenoid cystic carcinoma 10.4 NKX2-1 HRAS
39 vulvar melanoma 10.4 NRAS HRAS
40 ovarian cyst 10.3
41 adenoma 10.3
42 pseudo-meigs syndrome 10.3
43 sporadic pheochromocytoma 10.3 RET HRAS
44 core binding factor acute myeloid leukemia 10.3 NRAS HRAS
45 papillary thyroid microcarcinoma 10.3 TG NKX2-1
46 malignant skin fibrous histiocytoma 10.3 NRAS HRAS
47 anal canal adenocarcinoma 10.2 KRT19 HRAS
48 malignant dermis tumor 10.2 NRAS HRAS
49 biliary papillomatosis 10.2 KRT19 HRAS
50 colloid carcinoma of the pancreas 10.2 KRT19 HRAS

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to Malignant Struma Ovarii

Symptoms & Phenotypes for Malignant Struma Ovarii

MGI Mouse Phenotypes related to Malignant Struma Ovarii:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.11 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
2 homeostasis/metabolism MP:0005376 10.11 AFP HRAS LGALS3 NCOA4 NKX2-1 NRAS
3 endocrine/exocrine gland MP:0005379 10.1 AFP HRAS KRT19 NKX2-1 NRAS PTCH1
4 behavior/neurological MP:0005386 10.09 AFP HRAS LGALS3 NKX2-1 NRAS PTCH1
5 cardiovascular system MP:0005385 10.08 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
6 growth/size/body region MP:0005378 10.08 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
7 cellular MP:0005384 10.07 KRT19 LGALS3 NCOA4 NKX2-1 NRAS PTCH1
8 mortality/aging MP:0010768 10.03 AFP HRAS KRT19 LGALS3 NKX2-1 NRAS
9 neoplasm MP:0002006 10.01 AFP HRAS KRT19 LGALS3 NKX2-1 NRAS
10 nervous system MP:0003631 9.91 HRAS KRT19 LGALS3 NKX2-1 PTCH1 RET
11 no phenotypic analysis MP:0003012 9.8 HRAS KRT19 NKX2-1 NRAS PTCH1 RET
12 normal MP:0002873 9.73 HRAS KRT19 NKX2-1 NRAS PTCH1 RET
13 reproductive system MP:0005389 9.63 AFP KRT19 LGALS3 NKX2-1 PTCH1 RET
14 respiratory system MP:0005388 9.35 HRAS LGALS3 NKX2-1 PTCH1 RET
15 skeleton MP:0005390 9.17 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1

Drugs & Therapeutics for Malignant Struma Ovarii

Drugs for Malignant Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones
2 Hormone Antagonists
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pharmacokinetic and Pharmacodynamic Studies of Liothyronine. A Study on the Metabolic Effects of Thyroid Hormone Completed NCT01441154

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

Anatomical Context for Malignant Struma Ovarii

MalaCards organs/tissues related to Malignant Struma Ovarii:

41
Thyroid, Ovary, Liver, Bone, Eye, Lymph Node

Publications for Malignant Struma Ovarii

Articles related to Malignant Struma Ovarii:

(show top 50) (show all 146)
# Title Authors PMID Year
1
Unusual Case of Malignant Struma Ovarii and Cervical Thyroid Cancer Preceded by Ovarian Teratoma: Case Report and Review of the Literature. 38
31007958 2019
2
Complete Remission After Single Radioiodine Therapy in Malignant Struma Ovarii With Bone and Lymph Node Metastases. 38
30394923 2019
3
Extensive peritoneal implant metastases of malignant struma ovarii treated by thyroidectomy and 131I therapy: A case report. 38
30572559 2018
4
The Smallest Reported Malignant Struma Ovarii: A Case Report. 38
30483100 2018
5
Synchronous Independent Papillary Thyroid Carcinomas in Struma Ovarii and the Thyroid Gland With Different RAS Mutations. 38
30087949 2018
6
Transplantation of cryopreserved ovarian tissue in a patient affected by metastatic struma ovarii and endometriosis. 38
29318892 2018
7
Erratum: Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii. 38
29794490 2018
8
Rare Clinical Entity: Metastatic malignant struma ovarii diagnosed during pregnancy - Lessons for management. 38
29946481 2018
9
An unusual presentation of a papillary thyroid carcinoma in the struma ovarii in a 10 year-old girl: A case report. 38
30196119 2018
10
The largest reported papillary thyroid carcinoma arising in struma ovarii and metastasis to opposite ovary: case report and review of literature. 38
30061934 2018
11
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. 38
29286966 2017
12
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. 38
29278520 2017
13
Metastatic malignant struma ovarii: Two scenarios of the same pathology. 38
28440778 2017
14
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. 38
28982046 2017
15
Malignant Struma ovarii in a 30-year old nulliparous patient. 38
28572843 2017
16
Malignant struma ovarii with insular carcinoma: A case report and literature review. 38
29607388 2016
17
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. 38
27843812 2016
18
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. 38
27566096 2016
19
Sincronous malignant struma ovarii and papillary thyroid carcinoma. 38
27297016 2016
20
Management dilemma of thyroid nodules in patients with malignant struma ovarii. 38
27563566 2016
21
Treatment and follow-up of malignant struma ovarii: Regarding two cases. 38
27355004 2016
22
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. 38
26630220 2016
23
[Benign struma ovarii: Report of 7 cases and review of the literature]. 38
26997461 2016
24
A Hormonally Active Malignant Struma Ovarii. 38
27882257 2016
25
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. 38
27224256 2016
26
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. 38
26791568 2016
27
Papillary Carcinoma in Mature Teratoma of Struma Ovarii. 38
30039072 2015
28
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. 38
26262453 2015
29
Late Manifestation of Struma Peritonei and Widespread Functioning Lesions in the Setting of Struma Ovarii Simulating Highly Differentiated Follicular Carcinoma. 38
25537757 2015
30
Sonographic and Pathologic Features of Struma Ovarii. 38
26149143 2015
31
Follicular proliferative lesion arising in struma ovarii. 38
26018519 2015
32
The lack of consensus in management of malignant struma ovarii. 38
25539066 2015
33
Spinal metastasis from struma ovarii: case report and review of the literature. 38
25901242 2015
34
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. 38
25375817 2015
35
Hashimoto thyroiditis onset after laparoscopic removal of struma ovarii: an overview to unravel a rare and intriguing finding. 38
26524822 2015
36
A case report of thyroid carcinoma confined to ovary and concurrently occult in the thyroid: is conservative treatment always advised? 38
25745492 2015
37
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. 38
25364407 2014
38
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. 38
25474425 2014
39
[Clinical study on 68 cases with struma ovarii]. 38
25169639 2014
40
Struma ovarii: role of imaging? 38
24357453 2014
41
131I therapy using rhTSH stimulation and dosimetry in metastatic malignant struma ovarii. 38
24152665 2014
42
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. 38
24217901 2013
43
Synchronous papillary carcinoma thyroid with malignant struma ovarii: A management dilemma. 38
24379539 2013
44
Two cases of malignant struma ovarii with metastasis to pelvic bone. 38
23391779 2013
45
Struma ovarii maligna. 38
23645304 2013
46
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. 38
22883659 2012
47
Papillary thyroid cancer arising in struma ovarii. 38
22369392 2012
48
Papillary type thyroid carcinoma in an ovarian struma. 38
20339953 2012
49
Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. 38
22288964 2012
50
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. 38
21531638 2011

Variations for Malignant Struma Ovarii

Expression for Malignant Struma Ovarii

Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for Malignant Struma Ovarii

Pathways related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 RET NRAS NCOA4 HRAS
2 12.08 RET PTCH1 NRAS NCOA4 HRAS
3 12.01 PTCH1 NRAS HRAS
4 11.91 PTCH1 NRAS HRAS
5
Show member pathways
11.8 RET NRAS HRAS
6
Show member pathways
11.35 RET NRAS HRAS
7 11.25 NKX2-1 AFP
8 11.23 NRAS HRAS
9 11.17 RET NRAS HRAS
10 11.16 RET HRAS
11 11.15 RET HRAS
12 11.09 NRAS HRAS
13 11.03 NRAS HRAS
14 11.02 NRAS HRAS
15
Show member pathways
11 NRAS HRAS
16
Show member pathways
10.93 NRAS HRAS
17 10.82 NRAS HRAS
18 10.78 NRAS HRAS
19 10.67 NRAS HRAS
20 10.48 RET NRAS HRAS
21 10.44 NRAS HRAS
22 10.07 RET HRAS

GO Terms for Malignant Struma Ovarii

Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.46 RET PTCH1 NKX2-1 NCOA4
2 MAPK cascade GO:0000165 9.43 RET NRAS HRAS
3 thyroid gland development GO:0030878 8.96 TG NKX2-1
4 animal organ morphogenesis GO:0009887 8.8 PTCH1 NKX2-1 HRAS

Sources for Malignant Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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