MCID: MLG059
MIFTS: 39

Malignant Struma Ovarii

Categories: Endocrine diseases, Reproductive diseases, Cancer diseases

Aliases & Classifications for Malignant Struma Ovarii

MalaCards integrated aliases for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 12 15
Struma Ovarii, Malignant 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5208
NCIt 50 C4291
SNOMED-CT 68 18854008
UMLS 73 C0334525

Summaries for Malignant Struma Ovarii

MalaCards based summary : Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to struma ovarii and ovarian germ cell teratoma. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hormone Antagonists and Hormones have been mentioned in the context of this disorder. Affiliated tissues include thyroid, liver and ovary, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Malignant Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 struma ovarii 31.9 NKX2-1 RET TG
2 ovarian germ cell teratoma 29.8 NKX2-1 NRAS RET TG
3 thyroid cancer, nonmedullary, 1 28.1 LGALS3 NCOA4 NKX2-1 RET TG
4 papillary carcinoma 27.2 KRT19 LGALS3 NCOA4 NKX2-1 RET TG
5 thyroid cancer, nonmedullary, 2 27.2 HRAS KRT19 LGALS3 NKX2-1 NRAS RET
6 thyroid cancer 25.2 HRAS KRT19 LGALS3 NCOA4 NKX2-1 NRAS
7 giant congenital nevus 10.6 HRAS NRAS
8 athyreosis 10.6 NKX2-1 TG
9 schimmelpenning-feuerstein-mims syndrome 10.6 HRAS NRAS
10 ovarian melanoma 10.6 HRAS NRAS
11 malignant conjunctival melanoma 10.6 HRAS NRAS
12 melanomatosis 10.6 HRAS NRAS
13 thyroiditis 10.6
14 marcus gunn phenomenon 10.6 HRAS NRAS
15 myelodysplastic myeloproliferative cancer 10.6 HRAS NRAS
16 meningeal melanomatosis 10.5 HRAS NRAS
17 nevus, epidermal 10.5 HRAS NRAS
18 melanocytic nevus syndrome, congenital 10.5 HRAS NRAS
19 chromosome 14q11-q22 deletion syndrome 10.5 HRAS NKX2-1
20 vulvar melanoma 10.5 HRAS NRAS
21 acneiform dermatitis 10.5 HRAS NRAS
22 sporadic pheochromocytoma 10.5 HRAS RET
23 lung adenoid cystic carcinoma 10.5 HRAS NKX2-1
24 adenosquamous cell lung carcinoma 10.5 HRAS RET
25 papillary thyroid microcarcinoma 10.5 NKX2-1 TG
26 multiple endocrine neoplasia, type iib 10.4 PTCH1 RET
27 malignant skin fibrous histiocytoma 10.4 HRAS NRAS
28 core binding factor acute myeloid leukemia 10.4 HRAS NRAS
29 ovarian cystic teratoma 10.4 NKX2-1 TG
30 anal canal adenocarcinoma 10.3 HRAS KRT19
31 cystadenofibroma 10.3 AFP TG
32 biliary papillomatosis 10.3 HRAS KRT19
33 rete testis adenocarcinoma 10.3 AFP NKX2-1
34 malignant dermis tumor 10.3 HRAS NRAS
35 colloid carcinoma of the pancreas 10.3 HRAS KRT19
36 graves' disease 10.3
37 rete testis neoplasm 10.2 AFP NKX2-1
38 intrahepatic bile duct adenoma 10.2 AFP KRT19
39 thyroid carcinoma, familial medullary 10.2 NKX2-1 RET TG
40 central nervous system melanocytic neoplasm 10.2 HRAS NRAS
41 mucinous bronchioloalveolar adenocarcinoma 10.2 LGALS3 NKX2-1
42 renal pelvis adenocarcinoma 10.2 AFP KRT19
43 multinodular goiter 10.2 HRAS NKX2-1 TG
44 teratoma 10.2
45 dyskinetic cerebral palsy 10.1 AFP NKX2-1
46 integumentary system cancer 10.1 HRAS NRAS PTCH1
47 germ cell and embryonal cancer 10.0 AFP TG
48 malignant teratoma 10.0 AFP NKX2-1 TG
49 lymphedema, hereditary, ii 10.0
50 cervicitis 10.0

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to Malignant Struma Ovarii

Symptoms & Phenotypes for Malignant Struma Ovarii

GenomeRNAi Phenotypes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.4 NRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.4 RET
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.4 NRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.4 RET
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.4 RET HRAS NRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.4 RET
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 HRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 NRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 HRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.4 HRAS

MGI Mouse Phenotypes related to Malignant Struma Ovarii:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 HRAS NCOA4 NKX2-1 AFP LGALS3 TG
2 behavior/neurological MP:0005386 10.08 LGALS3 HRAS NKX2-1 AFP NRAS PTCH1
3 endocrine/exocrine gland MP:0005379 10.08 HRAS NKX2-1 KRT19 AFP TG PTCH1
4 cardiovascular system MP:0005385 10.07 HRAS NKX2-1 KRT19 LGALS3 PTCH1 RET
5 cellular MP:0005384 10.05 LGALS3 NCOA4 NKX2-1 KRT19 RET NRAS
6 digestive/alimentary MP:0005381 10.04 HRAS NKX2-1 KRT19 LGALS3 PTCH1 RET
7 mortality/aging MP:0010768 10.03 LGALS3 HRAS NKX2-1 KRT19 AFP NRAS
8 neoplasm MP:0002006 10.01 HRAS NKX2-1 KRT19 AFP LGALS3 PTCH1
9 nervous system MP:0003631 9.91 LGALS3 HRAS NKX2-1 KRT19 RET TG
10 no phenotypic analysis MP:0003012 9.8 HRAS NKX2-1 KRT19 PTCH1 RET NRAS
11 normal MP:0002873 9.73 HRAS NKX2-1 KRT19 NRAS PTCH1 RET
12 reproductive system MP:0005389 9.63 NKX2-1 KRT19 AFP LGALS3 PTCH1 RET
13 respiratory system MP:0005388 9.35 LGALS3 HRAS NKX2-1 RET PTCH1
14 skeleton MP:0005390 9.1 LGALS3 HRAS NKX2-1 KRT19 NRAS PTCH1

Drugs & Therapeutics for Malignant Struma Ovarii

Drugs for Malignant Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormone Antagonists
2 Hormones
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

Anatomical Context for Malignant Struma Ovarii

MalaCards organs/tissues related to Malignant Struma Ovarii:

41
Thyroid, Liver, Ovary, Bone, Eye

Publications for Malignant Struma Ovarii

Articles related to Malignant Struma Ovarii:

(show top 50) (show all 88)
# Title Authors Year
1
Erratum: Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii. ( 29794490 )
2018
2
Rare Clinical Entity: Metastatic malignant struma ovarii diagnosed during pregnancy - Lessons for management. ( 29946481 )
2018
3
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. ( 29278520 )
2017
4
Metastatic malignant struma ovarii: Two scenarios of the same pathology. ( 28440778 )
2017
5
Malignant Struma ovarii in a 30-year old nulliparous patient. ( 28572843 )
2017
6
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. ( 28982046 )
2017
7
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. ( 29286966 )
2017
8
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
9
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
10
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
11
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
12
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
13
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
14
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
15
Malignant struma ovarii with insular carcinoma: A case report and literature review. ( 29607388 )
2016
16
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
17
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2015
18
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. ( 26262453 )
2015
19
The lack of consensus in management of malignant struma ovarii. ( 25539066 )
2014
20
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. ( 25375817 )
2014
21
131I Therapy Using rhTSH Stimulation and Dosimetry in Metastatic Malignant Struma Ovarii. ( 24152665 )
2014
22
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. ( 25364407 )
2014
23
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. ( 25474425 )
2014
24
Two cases of malignant struma ovarii with metastasis to pelvic bone. ( 23391779 )
2013
25
Synchronous papillary carcinoma thyroid with malignant struma ovarii: A management dilemma. ( 24379539 )
2013
26
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. ( 24217901 )
2013
27
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. ( 22883659 )
2012
28
Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. ( 22288964 )
2012
29
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. ( 21531638 )
2011
30
Malignant struma ovarii complicated by Trousseau's syndrome and repeated episodes of cerebral ischemic strokes: A case report. ( 24371609 )
2011
31
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. ( 21934226 )
2011
32
Metastatic malignant struma ovarii. ( 21598816 )
2011
33
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment. ( 21269611 )
2011
34
Malignant struma ovarii. ( 20375218 )
2010
35
Metastasis of malignant struma ovarii to the lumbar spine. ( 20036545 )
2010
36
Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread. ( 20407319 )
2010
37
Malignant struma ovarii: a case report. ( 20119594 )
2010
38
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. ( 19772400 )
2009
39
Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. ( 19696610 )
2009
40
Malignant struma ovarii: good response after thyroidectomy and I ablation therapy. ( 21892277 )
2008
41
Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. ( 18496456 )
2008
42
Malignant struma ovarii. ( 18560398 )
2008
43
An unusual variant of malignant struma ovarii. ( 18678124 )
2008
44
Malignant struma ovarii--a case report and review of the literature. ( 17890867 )
2008
45
Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. ( 17882443 )
2008
46
Malignant struma ovarii: a case report and review of the literature. ( 17646728 )
2007
47
BRAF T1799A mutation occurring in a case of malignant struma ovarii. ( 17478764 )
2007
48
Malignant struma ovarii mimic clear cell carcinoma. ( 14986024 )
2005
49
Malignant struma ovarii with peritoneal implants and pelvic structures and liver metastases demonstrated by I-131 SPECT and low-dose CT. ( 16319636 )
2005
50
Malignant struma ovarii: a case report. ( 16047952 )
2005

Variations for Malignant Struma Ovarii

Expression for Malignant Struma Ovarii

Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for Malignant Struma Ovarii

Pathways related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

(show all 20)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 HRAS NCOA4 NRAS RET
2 12.07 HRAS NCOA4 NRAS PTCH1 RET
3 12 HRAS NRAS PTCH1
4 11.9 HRAS NRAS PTCH1
5
Show member pathways
11.63 HRAS NRAS RET
6
Show member pathways
11.35 HRAS NRAS RET
7 11.21 HRAS NRAS
8 11.16 HRAS RET
9 11.15 HRAS RET
10 11.14 HRAS NRAS RET
11 11.1 HRAS NRAS
12 11.03 HRAS NRAS
13 11.02 HRAS NRAS
14
Show member pathways
11 HRAS NRAS
15
Show member pathways
10.93 HRAS NRAS
16 10.82 HRAS NRAS
17 10.78 HRAS NRAS
18 10.71 HRAS NRAS
19 10.48 HRAS NRAS RET
20 10.44 HRAS NRAS

GO Terms for Malignant Struma Ovarii

Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.56 NCOA4 NKX2-1 PTCH1 RET
2 ERBB2 signaling pathway GO:0038128 9.32 HRAS NRAS
3 thyroid gland development GO:0030878 9.16 NKX2-1 TG
4 animal organ morphogenesis GO:0009887 9.13 HRAS NKX2-1 PTCH1
5 axon guidance GO:0007411 8.92 HRAS NKX2-1 NRAS RET

Sources for Malignant Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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