MCID: MLG059
MIFTS: 39

Malignant Struma Ovarii

Categories: Cancer diseases, Endocrine diseases, Reproductive diseases

Aliases & Classifications for Malignant Struma Ovarii

MalaCards integrated aliases for Malignant Struma Ovarii:

Name: Malignant Struma Ovarii 12 15
Struma Ovarii, Malignant 12 74

Classifications:



External Ids:

Disease Ontology 12 DOID:5208
NCIt 51 C4291
SNOMED-CT 69 18854008
UMLS 74 C0334525

Summaries for Malignant Struma Ovarii

Disease Ontology : 12 A struma ovarii that is cancerous.

MalaCards based summary : Malignant Struma Ovarii, also known as struma ovarii, malignant, is related to struma ovarii and ovarian germ cell teratoma. An important gene associated with Malignant Struma Ovarii is TG (Thyroglobulin), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Hormones and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lung and liver, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Malignant Struma Ovarii

Diseases in the Struma Ovarii family:

Malignant Struma Ovarii Benign Struma Ovarii

Diseases related to Malignant Struma Ovarii via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 struma ovarii 32.0 NKX2-1 RET TG
2 ovarian germ cell teratoma 30.4 NKX2-1 NRAS RET TG
3 hashimoto thyroiditis 29.9 KRT19 LGALS3 RET TG
4 papillary carcinoma 29.1 KRT19 LGALS3 NCOA4 NKX2-1 RET TG
5 thyroid cancer, nonmedullary, 2 29.0 HRAS KRT19 LGALS3 NKX2-1 NRAS RET
6 thyroid cancer 28.5 HRAS KRT19 LGALS3 NCOA4 NKX2-1 NRAS
7 graves' disease 10.4
8 teratoma 10.4
9 thyroid cancer, nonmedullary, 1 10.4
10 graves disease 1 10.4
11 giant congenital nevus 10.3 HRAS NRAS
12 schimmelpenning-feuerstein-mims syndrome 10.3 HRAS NRAS
13 ovarian melanoma 10.3 HRAS NRAS
14 malignant conjunctival melanoma 10.3 HRAS NRAS
15 melanomatosis 10.3 HRAS NRAS
16 marcus gunn phenomenon 10.3 HRAS NRAS
17 athyreosis 10.3 NKX2-1 TG
18 nodular malignant melanoma 10.3 HRAS NRAS
19 myelodysplastic myeloproliferative cancer 10.3 HRAS NRAS
20 meningeal melanomatosis 10.3 HRAS NRAS
21 melanocytic nevus syndrome, congenital 10.3 HRAS NRAS
22 acneiform dermatitis 10.2 HRAS NRAS
23 chromosome 14q11-q22 deletion syndrome 10.2 HRAS NKX2-1
24 lung adenoid cystic carcinoma 10.2 HRAS NKX2-1
25 vulvar melanoma 10.2 HRAS NRAS
26 papillary thyroid microcarcinoma 10.2 NKX2-1 TG
27 adenocarcinoma 10.2
28 thyroiditis 10.2
29 pseudo-meigs syndrome 10.2
30 ovarian cystic teratoma 10.2 NKX2-1 TG
31 sporadic pheochromocytoma 10.2 HRAS RET
32 malignant skin fibrous histiocytoma 10.2 HRAS NRAS
33 core binding factor acute myeloid leukemia 10.2 HRAS NRAS
34 anal canal adenocarcinoma 10.2 HRAS KRT19
35 mature teratoma 10.1 AFP TG
36 malignant dermis tumor 10.1 HRAS NRAS
37 biliary papillomatosis 10.1 HRAS KRT19
38 mucinous bronchioloalveolar adenocarcinoma 10.1 LGALS3 NKX2-1
39 colloid carcinoma of the pancreas 10.1 HRAS KRT19
40 hypothyroidism 10.1 NKX2-1 RET TG
41 adenosquamous lung carcinoma 10.1 HRAS RET
42 cystadenofibroma 10.1 AFP TG
43 central nervous system melanocytic neoplasm 10.1 HRAS NRAS
44 thyroid carcinoma, familial medullary 10.1 NKX2-1 RET TG
45 multinodular goiter 10.1 HRAS NKX2-1 TG
46 rete testis adenocarcinoma 10.1 AFP NKX2-1
47 rete testis neoplasm 10.0 AFP NKX2-1
48 intrahepatic bile duct adenoma 10.0 AFP KRT19
49 nodular goiter 10.0 LGALS3 RET TG
50 renal pelvis adenocarcinoma 10.0 AFP KRT19

Graphical network of the top 20 diseases related to Malignant Struma Ovarii:



Diseases related to Malignant Struma Ovarii

Symptoms & Phenotypes for Malignant Struma Ovarii

GenomeRNAi Phenotypes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.4 NRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.4 RET
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.4 NRAS
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.4 RET
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.4 HRAS NRAS RET
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.4 RET
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 HRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 NRAS
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 HRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.4 HRAS

MGI Mouse Phenotypes related to Malignant Struma Ovarii:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 10.11 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
2 homeostasis/metabolism MP:0005376 10.11 AFP HRAS LGALS3 NCOA4 NKX2-1 NRAS
3 endocrine/exocrine gland MP:0005379 10.1 AFP HRAS KRT19 NKX2-1 NRAS PTCH1
4 behavior/neurological MP:0005386 10.09 AFP HRAS LGALS3 NKX2-1 NRAS PTCH1
5 cardiovascular system MP:0005385 10.08 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
6 growth/size/body region MP:0005378 10.08 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1
7 cellular MP:0005384 10.07 KRT19 LGALS3 NCOA4 NKX2-1 NRAS PTCH1
8 mortality/aging MP:0010768 10.03 AFP HRAS KRT19 LGALS3 NKX2-1 NRAS
9 neoplasm MP:0002006 10.01 AFP HRAS KRT19 LGALS3 NKX2-1 NRAS
10 nervous system MP:0003631 9.91 HRAS KRT19 LGALS3 NKX2-1 PTCH1 RET
11 no phenotypic analysis MP:0003012 9.8 HRAS KRT19 NKX2-1 NRAS PTCH1 RET
12 normal MP:0002873 9.73 HRAS KRT19 NKX2-1 NRAS PTCH1 RET
13 reproductive system MP:0005389 9.63 AFP KRT19 LGALS3 NKX2-1 PTCH1 RET
14 respiratory system MP:0005388 9.35 HRAS LGALS3 NKX2-1 PTCH1 RET
15 skeleton MP:0005390 9.17 HRAS KRT19 LGALS3 NKX2-1 NRAS PTCH1

Drugs & Therapeutics for Malignant Struma Ovarii

Drugs for Malignant Struma Ovarii (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones
2 Hormone Antagonists
3 Hormones, Hormone Substitutes, and Hormone Antagonists

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Metabolic Effects of Synthetic Thyroid Hormone for Thyroid Cancer Treatment Completed NCT01441154

Search NIH Clinical Center for Malignant Struma Ovarii

Genetic Tests for Malignant Struma Ovarii

Anatomical Context for Malignant Struma Ovarii

MalaCards organs/tissues related to Malignant Struma Ovarii:

42
Thyroid, Lung, Liver, Testis, Bone, Eye, Ovary

Publications for Malignant Struma Ovarii

Articles related to Malignant Struma Ovarii:

(show top 50) (show all 93)
# Title Authors Year
1
Complete Remission After Single Radioiodine Therapy in Malignant Struma Ovarii With Bone and Lymph Node Metastases. ( 30394923 )
2019
2
Unusual Case of Malignant Struma Ovarii and Cervical Thyroid Cancer Preceded by Ovarian Teratoma: Case Report and Review of the Literature. ( 31007958 )
2019
3
Erratum: Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii. ( 29794490 )
2018
4
Rare Clinical Entity: Metastatic malignant struma ovarii diagnosed during pregnancy - Lessons for management. ( 29946481 )
2018
5
The Smallest Reported Malignant Struma Ovarii: A Case Report. ( 30483100 )
2018
6
Extensive peritoneal implant metastases of malignant struma ovarii treated by thyroidectomy and 131I therapy: A case report. ( 30572559 )
2018
7
Metastatic malignant struma ovarii: Two scenarios of the same pathology. ( 28440778 )
2017
8
Malignant Struma ovarii in a 30-year old nulliparous patient. ( 28572843 )
2017
9
Treatment and follow-up in an asymptomatic malignant struma ovarii: A case report. ( 28982046 )
2017
10
Malignant struma ovarii harboring a unique NRAS mutation: case report and review of the literature. ( 29278520 )
2017
11
Isolated Scapular Metastasis in a Patient with Malignant Struma Ovarii: A Case Report. ( 29286966 )
2017
12
Malignant Struma Ovarii With a Predominant Component of Anaplastic Carcinoma. ( 26630220 )
2016
13
Papillary thyroid cancer located in malignant struma ovarii with omentum metastasis: a case report and review of the literature. ( 26791568 )
2016
14
Metastatic malignant struma ovarii with coexistence of Hashimoto's thyroiditis. ( 27224256 )
2016
15
Sincronous malignant struma ovarii and papillary thyroid carcinoma. ( 27297016 )
2016
16
Treatment and follow-up of malignant struma ovarii: Regarding two cases. ( 27355004 )
2016
17
Management dilemma of thyroid nodules in patients with malignant struma ovarii. ( 27563566 )
2016
18
Synchronous and Metachronous Malignancies After Malignant Struma Ovarii in the SEER Database. ( 27566096 )
2016
19
An Unusual Case of Malignant Struma Ovarii Causing Thyrotoxicosis. ( 27843812 )
2016
20
A Hormonally Active Malignant Struma Ovarii. ( 27882257 )
2016
21
Malignant struma ovarii with insular carcinoma: A case report and literature review. ( 29607388 )
2016
22
Malignant struma ovarii: a population-level analysis of a large series of 68 patients. ( 25375817 )
2015
23
The lack of consensus in management of malignant struma ovarii. ( 25539066 )
2015
24
Missed Initial Diagnosis of Malignant Struma Ovarii Containing Follicular Thyroid Carcinoma: Metastatic Pulmonary Recurrence 17 yr After Ovariectomy. ( 26262453 )
2015
25
131I therapy using rhTSH stimulation and dosimetry in metastatic malignant struma ovarii. ( 24152665 )
2014
26
Long-term survival in metastatic malignant struma ovarii treated with oral chemotherapy: A case report. ( 25364407 )
2014
27
Treatment for malignant struma ovarii in the eyes of thyroid surgeons: a case report and study of Chinese cases reported in the literature. ( 25474425 )
2014
28
Two cases of malignant struma ovarii with metastasis to pelvic bone. ( 23391779 )
2013
29
Coexistence of malignant struma ovarii and cervical papillary thyroid carcinoma. ( 24217901 )
2013
30
Synchronous papillary carcinoma thyroid with malignant struma ovarii: A management dilemma. ( 24379539 )
2013
31
Malignant struma ovarii: a blinded study of 86 cases assessing which histologic features correlate with aggressive clinical behavior. ( 22288964 )
2012
32
Malignant struma ovarii: the west of Scotland experience and review of literature with focus on postoperative management. ( 22883659 )
2012
33
Laparoscopic excision of malignant struma ovarii and 1 year follow-up without further treatment. ( 21269611 )
2011
34
Unusual characteristics and fatal outcome of a malignant struma ovarii. Case report and literature review. ( 21531638 )
2011
35
Metastatic malignant struma ovarii. ( 21598816 )
2011
36
Unilateral malignant struma ovarii in a case of bilateral ovarian teratoma with raised CA-125 level: a rare case with treatment dilemmas. ( 21934226 )
2011
37
Malignant struma ovarii complicated by Trousseau's syndrome and repeated episodes of cerebral ischemic strokes: A case report. ( 24371609 )
2011
38
Metastasis of malignant struma ovarii to the lumbar spine. ( 20036545 )
2010
39
Malignant struma ovarii: a case report. ( 20119594 )
2010
40
Malignant struma ovarii. ( 20375218 )
2010
41
Natural history of biologically malignant struma ovarii: analysis of 27 cases with extraovarian spread. ( 20407319 )
2010
42
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. ( 19772400 )
2009
43
Malignant struma ovarii: an analysis of 88 cases, including 27 with extraovarian spread. ( 19696610 )
2009
44
Malignant struma ovarii with a focus of papillary thyroid cancer: a case report. ( 17882443 )
2008
45
Malignant struma ovarii--a case report and review of the literature. ( 17890867 )
2008
46
Malignant struma ovarii demonstrated on post-therapy radioiodine scan after total thyroidectomy for papillary thyroid cancer. ( 18496456 )
2008
47
Malignant struma ovarii. ( 18560398 )
2008
48
An unusual variant of malignant struma ovarii. ( 18678124 )
2008
49
Malignant struma ovarii: good response after thyroidectomy and I ablation therapy. ( 21892277 )
2008
50
BRAF T1799A mutation occurring in a case of malignant struma ovarii. ( 17478764 )
2007

Variations for Malignant Struma Ovarii

Expression for Malignant Struma Ovarii

Search GEO for disease gene expression data for Malignant Struma Ovarii.

Pathways for Malignant Struma Ovarii

Pathways related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 HRAS NCOA4 NRAS RET
2 12.08 HRAS NCOA4 NRAS PTCH1 RET
3 12 HRAS NRAS PTCH1
4 11.91 HRAS NRAS PTCH1
5
Show member pathways
11.8 HRAS NRAS RET
6
Show member pathways
11.35 HRAS NRAS RET
7 11.25 AFP NKX2-1
8 11.23 HRAS NRAS
9 11.16 HRAS RET
10 11.16 HRAS RET
11 11.14 HRAS NRAS RET
12 11.1 HRAS NRAS
13 11.03 HRAS NRAS
14 11.02 HRAS NRAS
15
Show member pathways
11 HRAS NRAS
16
Show member pathways
10.93 HRAS NRAS
17 10.82 HRAS NRAS
18 10.78 HRAS NRAS
19 10.67 HRAS NRAS
20 10.48 HRAS NRAS RET
21 10.44 HRAS NRAS
22 10.06 HRAS RET

GO Terms for Malignant Struma Ovarii

Biological processes related to Malignant Struma Ovarii according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.46 NCOA4 NKX2-1 PTCH1 RET
2 MAPK cascade GO:0000165 9.43 HRAS NRAS RET
3 thyroid gland development GO:0030878 8.96 NKX2-1 TG
4 animal organ morphogenesis GO:0009887 8.8 HRAS NKX2-1 PTCH1

Sources for Malignant Struma Ovarii

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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