Malignant Syringoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: MLG049 MIFTS: 32	Malignant Syringoma Categories: Rare diseases, Skin diseases, Cancer diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Download Expand all tables

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Aliases & Classifications for Malignant Syringoma

MalaCards integrated aliases for Malignant Syringoma:

Name: Malignant Syringoma ¹² ¹⁵

Microcystic Adnexal Carcinoma ¹² ⁵³

Microcystic Adnexal Carcinoma of Skin ¹²

Syringomatous Carcinoma ¹²

Eccrine Epithelioma ⁷³

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:5569

UMLS ⁷³ C0346027

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Summaries for Malignant Syringoma

NIH Rare Diseases : ⁵³ Microcystic adnexal carcinoma is a rare tumor of the skin that most often develops in the head and neck region, particularly in the middle of the face, though it may occur in the skin of other parts of the body as well. The average age of diagnosis is 56. This tumor is often first noticed as a bump or yellowish spot in the skin. Though microcystic adnexal carcinomas frequently grow into and disturb nearby tissues and is therefore considered an invasive cancer, this type of tumor rarely spreads to more distant parts of the body (metastasizes). The main treatment for microcystic adnexal carcinoma is Mohs micrographic surgery, which is thought to improve the chances that all of the tumor cells are removed during surgery.

MalaCards based summary : Malignant Syringoma, also known as microcystic adnexal carcinoma, is related to nodular basal cell carcinoma and rete testis adenocarcinoma. An important gene associated with Malignant Syringoma is DAND5 (DAN Domain BMP Antagonist Family Member 5), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs nivolumab and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin and bone.

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Related Diseases for Malignant Syringoma

Diseases in the Syringoma family:

Syringomas, Multiple

Malignant Syringoma

Diseases related to Malignant Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)

#	Related Disease	Score	Top Affiliating Genes
1	nodular basal cell carcinoma	10.4	KRT15 KRT17
2	rete testis adenocarcinoma	10.1	KRT20 PTGER4
3	rete testis neoplasm	10.1	KRT20 PTGER4
4	hidrocystoma	10.0	KRT15 KRT7
5	apocrine sweat gland neoplasm	10.0	KRT15 KRT7
6	anus basaloid carcinoma	10.0	KRT7 PTGER4
7	clear cell basal cell carcinoma	10.0	KRT17 KRT7
8	endosalpingiosis	9.9	KRT7 PTGER4
9	actinic keratosis	9.9	KRT17 KRT20
10	syringoma	9.9
11	nodular hidradenoma	9.9	KRT7 PTGER4
12	bowen's disease	9.9	KRT17 KRT7
13	basaloid squamous cell carcinoma	9.8	KRT17 KRT7
14	pericardium cancer	9.8	KRT7 PTGER4
15	vaginal benign neoplasm	9.8	KRT20 KRT7
16	seminal vesicle adenocarcinoma	9.8	KRT20 KRT7
17	transverse colon cancer	9.8	KRT20 KRT7
18	appendix adenocarcinoma	9.8	KRT20 KRT7
19	ovarian large-cell neuroendocrine carcinoma	9.8	KRT20 KRT7
20	vaginal adenoma	9.8	KRT20 KRT7
21	vaginal tubulovillous adenoma	9.8	KRT20 KRT7
22	eyelid neoplasm	9.8	KRT20 KRT7
23	glandular cystitis	9.8	KRT20 KRT7
24	krukenberg carcinoma	9.8	KRT20 KRT7
25	large intestine adenocarcinoma	9.8	KRT20 KRT7
26	linitis plastica	9.8	KRT20 KRT7
27	lung acinar adenocarcinoma	9.8	KRT20 KRT7
28	small cell carcinoma of the bladder	9.8	KRT20 KRT7
29	adenoid squamous cell carcinoma	9.8	KRT20 KRT7
30	mucinous bronchioloalveolar adenocarcinoma	9.8	KRT20 KRT7
31	vulval paget's disease	9.8	KRT20 KRT7
32	bile duct cystadenocarcinoma	9.8	KRT20 KRT7
33	intratubular embryonal carcinoma	9.8	KRT20 KRT7
34	ovarian mucinous adenocarcinoma	9.8	KRT20 KRT7
35	gastric diffuse adenocarcinoma	9.8	KRT20 KRT7
36	meibomian cyst	9.8	KRT20 KRT7
37	bladder lymphoma	9.8	KRT20 KRT7
38	bladder adenocarcinoma	9.8	KRT20 KRT7
39	jejunal adenocarcinoma	9.8	KRT20 KRT7
40	chronic cystitis	9.8	KRT20 KRT7
41	vulva adenocarcinoma	9.8	KRT20 KRT7
42	medulloepithelioma	9.8	KRT20 KRT7
43	glycogen-rich clear cell breast carcinoma	9.8	KRT20 KRT7
44	rectum adenocarcinoma	9.8	KRT20 KRT7
45	renal pelvis carcinoma	9.8	KRT20 KRT7
46	paget disease, extramammary	9.8	KRT20 KRT7
47	pericardial mesothelioma	9.8	KRT7 PTGER4
48	appendix cancer	9.8	KRT20 KRT7
49	mucinous cystadenocarcinoma	9.8	KRT20 KRT7
50	biliary papillomatosis	9.8	KRT20 KRT7

Graphical network of the top 20 diseases related to Malignant Syringoma:

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Symptoms & Phenotypes for Malignant Syringoma

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Drugs & Therapeutics for Malignant Syringoma

Drugs for Malignant Syringoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

nivolumab

Approved

Phase 2

946414-94-4

Antibodies

Phase 2

Immunoglobulins

Phase 2

Antibodies, Monoclonal

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers	Recruiting	NCT02978625	Phase 2

Search NIH Clinical Center for Malignant Syringoma

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Genetic Tests for Malignant Syringoma

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Anatomical Context for Malignant Syringoma

MalaCards organs/tissues related to Malignant Syringoma:

⁴¹

Skin, Bone

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Publications for Malignant Syringoma

Articles related to Malignant Syringoma:

(show all 19)

#	Title	Authors	Year
1	Metastatic Microcystic Adnexal Carcinoma with DNA Sequencing Results and Response to Systemic Antineoplastic Chemotherapy. ( 28870941 )	Chen M.B....Laber D.A.	2017
2	Misdiagnosed microcystic adnexal carcinoma on the lateral forehead and challenges in reconstruction of a large and bone-deep defect. ( 26713651 )	Fallaha A....Eisendle K.	2016
3	An important mimicker: plaque-type syringoma mistakenly diagnosed as microcystic adnexal carcinoma. ( 25111356 )	Wallace J.S....Samie F.H.	2014
4	Expression of p75 neurotrophin receptor in desmoplastic trichoepithelioma, infiltrative basal cell carcinoma, and microcystic adnexal carcinoma. ( 23598854 )	Jedrych J....McNiff J.M.	2013
5	The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. ( 23398472 )	Sellheyer K....Patel R.M.	2013
6	Sweat duct proliferation associated with aggregates of elastic tissue and atrophodermia vermiculata: a simulator of microcystic adnexal carcinoma. Report of two cases. ( 20175822 )	Schaller J....Requena L.	2010
7	Supraorbital neuroma masquerading as local recurrence from a previously excised microcystic adnexal carcinoma. ( 19648071 )	Seaward J.R....Ross G.L.	2010
8	Microcystic adnexal carcinoma: an immunohistochemical reappraisal. ( 18065959 )	Hoang M.P....Mahalingam M.	2008
9	Plaque-type syringoma: two cases misdiagnosed as microcystic adnexal carcinoma. ( 18005172 )	Suwattee P....Niehans G.A.	2008
10	A microcystic adnexal carcinoma in the auditory canal 15 years after radiotherapy of a 12-year-old boy with nasopharynx carcinoma. ( 15925985 )	Beer K.T....Greiner R.	2005
11	Microcystic adnexal carcinoma: an immunohistochemical study including markers of proliferation and apoptosis. ( 11257620 )	Smith K.J....Skelton H.	2001
12	Sclerosing sweat-duct carcinoma (malignant syringoma) of the upper eyelid: a patient report with immunohistochemical and ultrastructural analysis. ( 9842565 )	Esmaeli B....Harvey J.T.	1998
13	Eyelid microcystic adnexal carcinoma. ( 7710401 )	Hesse R.J....Griener E.	1995
14	Solitary syringoma. Report of five cases and clinicopathologic comparison with microcystic adnexal carcinoma of the skin. ( 8599451 )	Henner M.S....Wick M.R.	1995
15	Two perplexing skin tumors: microcystic adnexal carcinoma and keratoacanthoma. ( 7944178 )	Batsakis J.G....Weber R.S.	1994
16	Combined microcystic adnexal carcinoma and squamous cell carcinoma arising in the ovarian cystic teratoma--a brief case report. ( 7702793 )	Yoon H.K....Joo J.E.	1994
17	Microcystic adnexal carcinoma: a case report with immunohistochemical and electron microscopical examinations. ( 1593021 )	Kato N....Ueno H.	1992
18	Microcystic adnexal carcinoma. An immunohistochemical comparison with other cutaneous appendage tumors. ( 1689137 )	Wick M.R....Sun T.T.	1990
19	Malignant syringoma of the eyelid. ( 6493709 )	Glatt H.J....Font R.L.	1984

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Genes for Malignant Syringoma

Genes related to Malignant Syringoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	DAND5	DAN Domain BMP Antagonist Family Member 5	Protein Coding	17.76	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	KRT15	Keratin 15	Protein Coding	16.43	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	PTGER4	Prostaglandin E Receptor 4	Protein Coding	15.02	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	KRT20	Keratin 20	Protein Coding	14.95	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	KRT7	Keratin 7	Protein Coding	14.72	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	KRT17	Keratin 17	Protein Coding	14.01	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Malignant Syringoma

Cosmic variations for Malignant Syringoma:

⁹

(show top 50) (show all 361)

#	Cosmic Mut ID	Gene Symbol	COSMIC Disease Classification (Primary site, Site subtype, Primary histology, Histology subtype)	Mutation CDS	Mutation AA	GRCh38 Location	Conf
1	COSM44097	TP53	skin,face,carcinoma,NS	c.530C>T	p.P177L	17:7675082-7675082	8
2	COSM10728	TP53	skin,face,carcinoma,NS	c.839G>A	p.R280K	17:7673781-7673781	8
3	COSM10988	TP53	skin,face,carcinoma,NS	c.772G>A	p.E258K	17:7674191-7674191	8
4	COSM10705	TP53	skin,face,carcinoma,NS	c.586C>T	p.R196*	17:7674945-7674945	8
5	COSM44295	TP53	skin,face,carcinoma,NS	c.993+1G>A	p.?	17:7673534-7673534	8
6	COSM10939	TP53	skin,face,carcinoma,NS	c.832C>T	p.P278S	17:7673788-7673788	8
7	COSM43544	TP53	skin,face,carcinoma,NS	c.260C>A	p.P87Q	17:7676109-7676109	8
8	COSM44326	TP53	skin,face,carcinoma,NS	c.706T>C	p.Y236H	17:7674257-7674257	8
9	COSM10662	TP53	skin,face,carcinoma,NS	c.743G>A	p.R248Q	17:7674220-7674220	8
10	COSM11449	TP53	skin,face,carcinoma,NS	c.388C>T	p.L130F	17:7675224-7675224	8
11	COSM44068	TP53	skin,face,carcinoma,NS	c.532C>A	p.H178N	17:7675080-7675080	8
12	COSM43582	TP53	skin,face,carcinoma,NS	c.454C>T	p.P152S	17:7675158-7675158	8
13	COSM10654	TP53	skin,face,carcinoma,NS	c.637C>T	p.R213*	17:7674894-7674894	8
14	COSM10656	TP53	skin,face,carcinoma,NS	c.742C>T	p.R248W	17:7674221-7674221	8
15	COSM44552	TP53	skin,face,carcinoma,NS	c.509C>T	p.T170M	17:7675103-7675103	8
16	COSM45830	TP53	skin,face,carcinoma,NS	c.766A>C	p.T256P	17:7674197-7674197	8
17	COSM10812	TP53	skin,face,carcinoma,NS	c.722C>T	p.S241F	17:7674241-7674241	8
18	COSM10726	TP53	skin,face,carcinoma,NS	c.856G>A	p.E286K	17:7673764-7673764	8
19	COSM10992	TP53	skin,face,carcinoma,NS	c.844C>G	p.R282G	17:7673776-7673776	8
20	COSM45304	TP53	skin,face,carcinoma,NS	c.375+1G>A	p.?	17:7675993-7675993	8
21	COSM43588	TP53	skin,face,carcinoma,NS	c.740A>C	p.N247T	17:7674223-7674223	8
22	COSM11081	TP53	skin,face,carcinoma,NS	c.733G>T	p.G245C	17:7674230-7674230	8
23	COSM11073	TP53	skin,face,carcinoma,NS	c.1024C>T	p.R342*	17:7670685-7670685	8
24	COSM45733	TP53	skin,face,carcinoma,NS	c.432G>A	p.Q144Q	17:7675180-7675180	8
25	COSM10704	TP53	skin,face,carcinoma,NS	c.844C>T	p.R282W	17:7673776-7673776	8
26	COSM43700	TP53	skin,face,carcinoma,NS	c.712T>A	p.C238S	17:7674251-7674251	8
27	COSM10733	TP53	skin,face,carcinoma,NS	c.574C>T	p.Q192*	17:7674957-7674957	8
28	COSM44227	TP53	skin,face,carcinoma,NS	c.854A>T	p.E285V	17:7673766-7673766	8
29	COSM10768	TP53	skin,face,carcinoma,NS	c.535C>T	p.H179Y	17:7675077-7675077	8
30	COSM43651	TP53	skin,face,carcinoma,NS	c.763A>T	p.I255F	17:7674200-7674200	8
31	COSM44435	TP53	skin,face,carcinoma,NS	c.96+1G>A	p.?	17:7676381-7676381	8
32	COSM43920	TP53	skin,face,carcinoma,NS	c.680C>T	p.S227F	17:7674283-7674283	8
33	COSM44436	TP53	skin,face,carcinoma,NS	c.375+2T>C	p.?	17:7675992-7675992	8
34	COSM43596	TP53	skin,face,carcinoma,NS	c.841G>A	p.D281N	17:7673779-7673779	8
35	COSM10749	TP53	skin,face,carcinoma,NS	c.830G>T	p.C277F	17:7673790-7673790	8
36	COSM11084	TP53	skin,face,carcinoma,NS	c.517G>A	p.V173M	17:7675095-7675095	8
37	COSM43742	TP53	skin,face,carcinoma,NS	c.419C>T	p.T140I	17:7675193-7675193	8
38	COSM10887	TP53	skin,face,carcinoma,NS	c.833C>G	p.P278R	17:7673787-7673787	8
39	COSM44241	TP53	skin,face,carcinoma,NS	c.592G>T	p.E198*	17:7674939-7674939	8
40	COSM43665	TP53	skin,face,carcinoma,NS	c.746G>C	p.R249T	17:7674217-7674217	8
41	COSM45677	TP53	skin,face,carcinoma,NS	c.714T>A	p.C238*	17:7674249-7674249	8
42	COSM607136	TGFBR1	skin,neck,carcinoma,NS	c.1247C>T	p.S416F	9:99146601-99146601	8
43	COSM13234	SUFU	skin,face,carcinoma,NS	c.560C>T	p.P187L	10:102592687-102592687	8
44	COSM13233	SUFU	skin,face,carcinoma,NS	c.591C>T	p.F197F	10:102592718-102592718	8
45	COSM3942016	SMO	skin,face,carcinoma,NS	c.1376C>T	p.A459V	7:129209307-129209307	8
46	COSM13146	SMO	skin,face,carcinoma,NS	c.1604G>T	p.W535L	7:129210500-129210500	8
47	COSM6962965	SMO	skin,neck,carcinoma,NS	c.1103C>T	p.P368L	7:129206332-129206332	8
48	COSM13144	SMO	skin,face,carcinoma,NS	c.1598G>A	p.S533N	7:129210494-129210494	8
49	COSM13145	SMO	skin,face,carcinoma,NS	c.595C>T	p.R199W	7:129205260-129205260	8
50	COSM216037	SMO	skin,face,carcinoma,NS	c.1234C>T	p.L412F	7:129206557-129206557	8

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Expression for Malignant Syringoma

Search GEO for disease gene expression data for Malignant Syringoma.

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Pathways for Malignant Syringoma

Pathways related to Malignant Syringoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	12.57	DAND5 KRT15 KRT17 KRT20 KRT7
2	Cytoskeletal Signaling ⁴	11.82	KRT17 KRT20 KRT7
3	Keratinization ⁶⁶ Show member pathways Formation of the cornified envelope ⁶⁶	11.38	KRT15 KRT17 KRT20 KRT7
4	Cytoskeleton remodeling Neurofilaments ²² Show member pathways Cytoskeleton remodeling Keratin filaments ²²	11.29	KRT17 KRT7

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GO Terms for Malignant Syringoma

Cellular components related to Malignant Syringoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intermediate filament	GO:0005882	8.92	KRT15 KRT17 KRT20 KRT7

Biological processes related to Malignant Syringoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	epidermis development	GO:0008544	9.26	KRT15 KRT17
2	keratinization	GO:0031424	9.26	KRT15 KRT17 KRT20 KRT7
3	intermediate filament organization	GO:0045109	9.16	KRT17 KRT20
4	cornification	GO:0070268	8.92	KRT15 KRT17 KRT20 KRT7

Molecular functions related to Malignant Syringoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of cytoskeleton	GO:0005200	8.8	KRT15 KRT17 KRT20

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Sources for Malignant Syringoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia