MCID: MLG049
MIFTS: 32

Malignant Syringoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Malignant Syringoma

MalaCards integrated aliases for Malignant Syringoma:

Name: Malignant Syringoma 12 15
Microcystic Adnexal Carcinoma 12 53
Microcystic Adnexal Carcinoma of Skin 12
Syringomatous Carcinoma 12
Eccrine Epithelioma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5569
UMLS 73 C0346027

Summaries for Malignant Syringoma

NIH Rare Diseases : 53 Microcystic adnexal carcinoma is a rare tumor of the skin that most often develops in the head and neck region, particularly in the middle of the face, though it may occur in the skin of other parts of the body as well. The average age of diagnosis is 56. This tumor is often first noticed as a bump or yellowish spot in the skin.  Though microcystic adnexal carcinomas frequently grow into and disturb nearby tissues and is therefore considered an invasive cancer, this type of tumor rarely spreads to more distant parts of the body (metastasizes). The main treatment for microcystic adnexal carcinoma is Mohs micrographic surgery, which is thought to improve the chances that all of the tumor cells are removed during surgery.

MalaCards based summary : Malignant Syringoma, also known as microcystic adnexal carcinoma, is related to basal cell carcinoma and meibomian cyst. An important gene associated with Malignant Syringoma is DAND5 (DAN Domain BMP Antagonist Family Member 5), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Nivolumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and t cells.

Related Diseases for Malignant Syringoma

Diseases in the Syringoma family:

Syringomas, Multiple Malignant Syringoma

Diseases related to Malignant Syringoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 basal cell carcinoma 30.2 KRT15 KRT20 KRT7
2 meibomian cyst 30.0 KRT20 KRT7
3 cystic teratoma 30.0 KRT20 KRT7
4 ovarian cystic teratoma 30.0 KRT20 KRT7
5 eyelid carcinoma 30.0 KRT20 KRT7
6 morpheaform basal cell carcinoma 29.8 DAND5 KRT15 KRT20
7 infiltrative basal cell carcinoma 29.5 DAND5 KRT15 KRT20 KRT7
8 basal cell carcinoma 1 10.4
9 squamous cell carcinoma 10.3
10 adenocarcinoma 10.2
11 malignant acrospiroma 10.2
12 hidrocystoma 10.1 KRT15 KRT7
13 apocrine sweat gland neoplasm 10.1 KRT15 KRT7
14 syringoma 10.1
15 gastric cancer 10.1
16 alopecia 10.1
17 lymphoma 10.1
18 cutaneous t cell lymphoma 10.1
19 telangiectasis 10.1
20 neuroma 10.1
21 keratoacanthoma 10.1
22 teratoma 10.1
23 external ear carcinoma 10.1
24 herpes simplex 10.1
25 viral infectious disease 10.1
26 anus basaloid carcinoma 10.1 KRT7 PTGER4
27 benign mesothelioma 10.1 KRT7 PTGER4
28 endosalpingiosis 10.1 KRT7 PTGER4
29 large cell acanthoma 10.1 KRT7 PTGER4
30 nodular hidradenoma 10.0 KRT7 PTGER4
31 peritoneum cancer 10.0 KRT7 PTGER4
32 pericardium cancer 10.0 KRT7 PTGER4
33 pericardial mesothelioma 10.0 KRT7 PTGER4
34 seminal vesicle adenocarcinoma 10.0 KRT20 KRT7
35 transverse colon cancer 10.0 KRT20 KRT7
36 appendix adenocarcinoma 10.0 KRT20 KRT7
37 glandular cystitis 10.0 KRT20 KRT7
38 papillary transitional carcinoma 10.0 KRT20 KRT7
39 krukenberg carcinoma 10.0 KRT20 KRT7
40 large intestine adenocarcinoma 10.0 KRT20 KRT7
41 linitis plastica 10.0 KRT20 KRT7
42 lung acinar adenocarcinoma 10.0 KRT20 KRT7
43 small cell carcinoma of the bladder 10.0 KRT20 KRT7
44 small cell carcinoma 10.0 KRT20 KRT7
45 adenoid squamous cell carcinoma 10.0 KRT20 KRT7
46 intratubular embryonal carcinoma 10.0 KRT20 KRT7
47 vulval paget's disease 10.0 KRT20 KRT7
48 bile duct cystadenocarcinoma 10.0 KRT20 KRT7
49 bile duct adenoma 10.0 KRT20 KRT7
50 jejunal adenocarcinoma 10.0 KRT20 KRT7

Graphical network of the top 20 diseases related to Malignant Syringoma:



Diseases related to Malignant Syringoma

Symptoms & Phenotypes for Malignant Syringoma

Drugs & Therapeutics for Malignant Syringoma

Drugs for Malignant Syringoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nivolumab Approved Phase 2 946414-94-4
2 Antibodies, Monoclonal Phase 2
3 Antibodies Phase 2
4 Immunoglobulins Phase 2
5 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Talimogene Laherparepvec and Nivolumab in Treating Patients With Refractory Lymphomas or Advanced or Refractory Non-melanoma Skin Cancers Recruiting NCT02978625 Phase 2

Search NIH Clinical Center for Malignant Syringoma

Genetic Tests for Malignant Syringoma

Anatomical Context for Malignant Syringoma

MalaCards organs/tissues related to Malignant Syringoma:

41
Skin, Lung, T Cells, Kidney, Testis, Thymus, Appendix

Publications for Malignant Syringoma

Articles related to Malignant Syringoma:

(show top 50) (show all 176)
# Title Authors Year
1
Microcystic adnexal carcinoma of the orbit mimicking pagetoid sebaceous gland carcinoma. ( 29053046 )
2018
2
Microcystic adnexal carcinoma with sebaceous differentiation: Three cases. ( 29352496 )
2018
3
A case and literature review of orbital microcystic adnexal carcinoma. ( 29461905 )
2018
4
Demographics and outcomes of microcystic adnexal carcinoma. ( 29559397 )
2018
5
Microcystic adnexal carcinoma-diagnostic criteria and therapeutic methods: case report and review of the literature. ( 29602625 )
2018
6
An Unusual Morphological Presentation of Cutaneous Squamous Cell Carcinoma Mimicking Microcystic Adnexal Carcinoma: A Diagnostic Pitfall. ( 29998100 )
2018
7
Microcystic Adnexal Carcinoma of the Nipple. ( 30059333 )
2018
8
Solid carcinoma is a variant of microcystic adnexal carcinoma: A 14-case series. ( 30187501 )
2018
9
Microcystic adnexal carcinoma of the external auditory canal. ( 30235377 )
2018
10
Microcystic adnexal carcinoma of the skin in atypical site (pubic region): clinical and dermatoscopic features. ( 30249079 )
2018
11
Metastatic Microcystic Adnexal Carcinoma with DNA Sequencing Results and Response to Systemic Antineoplastic Chemotherapy. ( 28870941 )
2017
12
Microcystic adnexal carcinoma mimicking basal cell carcinoma. ( 29034297 )
2017
13
Image Gallery: Microcystic adnexal carcinoma (syringomatous carcinoma and sclerosing sweat duct carcinoma) as an extensive sclerotic erythematous plaque with telangiectasia over the face. ( 28581237 )
2017
14
Microcystic adnexal carcinoma (MAC)-like squamous cell carcinoma as a differential diagnosis to Bell´s palsy: review of guidelines for refractory facial nerve palsy. ( 28057072 )
2017
15
An Aggressive Microcystic Adnexal Carcinoma Infiltrating the Sternum. ( 28300863 )
2017
16
Longstanding microcystic adnexal carcinoma in a child. ( 28542906 )
2017
17
Microcystic Adnexal Carcinoma: A Review of the Literature. ( 28654578 )
2017
18
Microcystic Adnexal Carcinoma and a Summary of Other Rare Malignant Adnexal Tumours. ( 28681209 )
2017
19
Microcystic adnexal carcinoma: unusual presentation. ( 25187439 )
2016
20
Treatments for microcystic adnexal carcinoma--A review. ( 26331917 )
2016
21
Longtime undetected microcystic adnexal carcinoma of the scalp: considerations and implications. ( 26556781 )
2016
22
Microcystic Adnexal Carcinoma Detected by Reflectance Confocal Microscopy. ( 26713597 )
2016
23
Misdiagnosed microcystic adnexal carcinoma on the lateral forehead and challenges in reconstruction of a large and bone-deep defect. ( 26713651 )
2016
24
Microcystic adnexal carcinoma in a non-Caucasian patient: A case report and review of the literature. ( 27073500 )
2016
25
Sclerosing Microcystic Adenocarcinoma of the Head and Neck Mucosa: A Neoplasm Closely Resembling Microcystic Adnexal Carcinoma. ( 27233253 )
2016
26
Diagnosis of pigmented microcystic adnexal carcinoma. ( 27595204 )
2016
27
Microcystic Adnexal Carcinoma of the Nasal Tip Treated With Surgical Excision and Rotational Forehead Skin Flap. ( 28005812 )
2016
28
SCLEROSING MICROCYSTIC ADNEXAL CARCINOMA OF THE SCALP (CASE REPORT). ( 28132035 )
2016
29
Microcystic Adnexal Carcinoma of the scalp in an african-american male. ( 28329609 )
2016
30
Correlation of optical coherence tomography and histology in microcystic adnexal carcinoma: a case report. ( 24528185 )
2015
31
The first reported case of metastatic microcystic adnexal carcinoma in an adolescent. ( 25627630 )
2015
32
Microcystic adnexal carcinoma of the cheek-a case report with dermatoscopy and dermatopathology. ( 25692080 )
2015
33
Anatomoclinical study of 30 cases of sclerosing sweat duct carcinomas (microcystic adnexal carcinoma, syringomatous carcinoma and squamoid eccrine ductal carcinoma). ( 25873411 )
2015
34
Microcystic adnexal carcinoma simulating scarring alopecia. ( 26312669 )
2015
35
Treatment of nasal microcystic adnexal carcinoma with an expanded rotational forehead skin flap: A case report and review of the literature. ( 26622465 )
2015
36
Dermoscopic findings of microcystic adnexal carcinoma. ( 26693638 )
2015
37
Microcystic Adnexal Carcinoma Misdiagnosed as Desmoplastic Trichoepithelioma on Preoperative Biopsy. ( 28913219 )
2015
38
An important mimicker: plaque-type syringoma mistakenly diagnosed as microcystic adnexal carcinoma. ( 25111356 )
2014
39
Microcystic adnexal carcinoma: successful management of a large scalp lesion. ( 23968368 )
2014
40
Benign subclinical syringomatous proliferations adjacent to a microcystic adnexal carcinoma: a tumor mimic with significant patient implications. ( 24061399 )
2014
41
Microcystic adnexal carcinoma: review of a potential diagnostic pitfall and management. ( 24738099 )
2014
42
Solid carcinoma revisited: a possible variant of microcystic adnexal carcinoma. ( 25343214 )
2014
43
Microcystic adnexal carcinoma in the axilla of an 18-year-old woman. ( 25424223 )
2014
44
Microcystic adnexal carcinoma: reconstruction of a large centrofacial defect. ( 25506537 )
2014
45
Expression of p75 neurotrophin receptor in desmoplastic trichoepithelioma, infiltrative basal cell carcinoma, and microcystic adnexal carcinoma. ( 23598854 )
2013
46
The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. ( 23398472 )
2013
47
Microcystic adnexal carcinoma versus desmoplastic trichoepithelioma: a comparative study. ( 22722464 )
2013
48
Microcystic adnexal carcinoma of the upper lip misdiagnosed benign desmoplastic trichoepithelioma. ( 22847035 )
2013
49
Microcystic adnexal carcinoma arising in a nevus sebaceous. ( 23723527 )
2013
50
Microcystic adnexal carcinoma of the face treated with radiation therapy: a case report and review of the literature. ( 21384456 )
2012

Variations for Malignant Syringoma

Cosmic variations for Malignant Syringoma:

9 (show top 50) (show all 361)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM44097 TP53 skin,face,carcinoma,NS c.530C>T p.P177L 17:7675082-7675082 8
2 COSM44295 TP53 skin,face,carcinoma,NS c.993+1G>A p.? 17:7673534-7673534 8
3 COSM10939 TP53 skin,face,carcinoma,NS c.832C>T p.P278S 17:7673788-7673788 8
4 COSM43544 TP53 skin,face,carcinoma,NS c.260C>A p.P87Q 17:7676109-7676109 8
5 COSM44326 TP53 skin,face,carcinoma,NS c.706T>C p.Y236H 17:7674257-7674257 8
6 COSM10662 TP53 skin,face,carcinoma,NS c.743G>A p.R248Q 17:7674220-7674220 8
7 COSM11449 TP53 skin,face,carcinoma,NS c.388C>T p.L130F 17:7675224-7675224 8
8 COSM44068 TP53 skin,face,carcinoma,NS c.532C>A p.H178N 17:7675080-7675080 8
9 COSM43582 TP53 skin,face,carcinoma,NS c.454C>T p.P152S 17:7675158-7675158 8
10 COSM10654 TP53 skin,face,carcinoma,NS c.637C>T p.R213* 17:7674894-7674894 8
11 COSM10656 TP53 skin,face,carcinoma,NS c.742C>T p.R248W 17:7674221-7674221 8
12 COSM44552 TP53 skin,face,carcinoma,NS c.509C>T p.T170M 17:7675103-7675103 8
13 COSM45830 TP53 skin,face,carcinoma,NS c.766A>C p.T256P 17:7674197-7674197 8
14 COSM10812 TP53 skin,face,carcinoma,NS c.722C>T p.S241F 17:7674241-7674241 8
15 COSM10726 TP53 skin,face,carcinoma,NS c.856G>A p.E286K 17:7673764-7673764 8
16 COSM10992 TP53 skin,face,carcinoma,NS c.844C>G p.R282G 17:7673776-7673776 8
17 COSM45304 TP53 skin,face,carcinoma,NS c.375+1G>A p.? 17:7675993-7675993 8
18 COSM43588 TP53 skin,face,carcinoma,NS c.740A>C p.N247T 17:7674223-7674223 8
19 COSM10705 TP53 skin,face,carcinoma,NS c.586C>T p.R196* 17:7674945-7674945 8
20 COSM11081 TP53 skin,face,carcinoma,NS c.733G>T p.G245C 17:7674230-7674230 8
21 COSM11073 TP53 skin,face,carcinoma,NS c.1024C>T p.R342* 17:7670685-7670685 8
22 COSM45733 TP53 skin,face,carcinoma,NS c.432G>A p.Q144Q 17:7675180-7675180 8
23 COSM10704 TP53 skin,face,carcinoma,NS c.844C>T p.R282W 17:7673776-7673776 8
24 COSM43700 TP53 skin,face,carcinoma,NS c.712T>A p.C238S 17:7674251-7674251 8
25 COSM10733 TP53 skin,face,carcinoma,NS c.574C>T p.Q192* 17:7674957-7674957 8
26 COSM44227 TP53 skin,face,carcinoma,NS c.854A>T p.E285V 17:7673766-7673766 8
27 COSM10768 TP53 skin,face,carcinoma,NS c.535C>T p.H179Y 17:7675077-7675077 8
28 COSM43651 TP53 skin,face,carcinoma,NS c.763A>T p.I255F 17:7674200-7674200 8
29 COSM44435 TP53 skin,face,carcinoma,NS c.96+1G>A p.? 17:7676381-7676381 8
30 COSM43920 TP53 skin,face,carcinoma,NS c.680C>T p.S227F 17:7674283-7674283 8
31 COSM44436 TP53 skin,face,carcinoma,NS c.375+2T>C p.? 17:7675992-7675992 8
32 COSM43596 TP53 skin,face,carcinoma,NS c.841G>A p.D281N 17:7673779-7673779 8
33 COSM10749 TP53 skin,face,carcinoma,NS c.830G>T p.C277F 17:7673790-7673790 8
34 COSM11084 TP53 skin,face,carcinoma,NS c.517G>A p.V173M 17:7675095-7675095 8
35 COSM43742 TP53 skin,face,carcinoma,NS c.419C>T p.T140I 17:7675193-7675193 8
36 COSM10887 TP53 skin,face,carcinoma,NS c.833C>G p.P278R 17:7673787-7673787 8
37 COSM44241 TP53 skin,face,carcinoma,NS c.592G>T p.E198* 17:7674939-7674939 8
38 COSM43665 TP53 skin,face,carcinoma,NS c.746G>C p.R249T 17:7674217-7674217 8
39 COSM10728 TP53 skin,face,carcinoma,NS c.839G>A p.R280K 17:7673781-7673781 8
40 COSM10988 TP53 skin,face,carcinoma,NS c.772G>A p.E258K 17:7674191-7674191 8
41 COSM45677 TP53 skin,face,carcinoma,NS c.714T>A p.C238* 17:7674249-7674249 8
42 COSM607136 TGFBR1 skin,neck,carcinoma,NS c.1247C>T p.S416F 9:99146601-99146601 8
43 COSM13233 SUFU skin,face,carcinoma,NS c.591C>T p.F197F 10:102592718-102592718 8
44 COSM13234 SUFU skin,face,carcinoma,NS c.560C>T p.P187L 10:102592687-102592687 8
45 COSM3942016 SMO skin,face,carcinoma,NS c.1376C>T p.A459V 7:129209307-129209307 8
46 COSM13146 SMO skin,face,carcinoma,NS c.1604G>T p.W535L 7:129210500-129210500 8
47 COSM6962965 SMO skin,neck,carcinoma,NS c.1103C>T p.P368L 7:129206332-129206332 8
48 COSM13144 SMO skin,face,carcinoma,NS c.1598G>A p.S533N 7:129210494-129210494 8
49 COSM13145 SMO skin,face,carcinoma,NS c.595C>T p.R199W 7:129205260-129205260 8
50 COSM216037 SMO skin,face,carcinoma,NS c.1234C>T p.L412F 7:129206557-129206557 8

Expression for Malignant Syringoma

Search GEO for disease gene expression data for Malignant Syringoma.

Pathways for Malignant Syringoma

Pathways related to Malignant Syringoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 DAND5 KRT15 KRT20 KRT7
2
Show member pathways
11.25 KRT15 KRT20 KRT7

GO Terms for Malignant Syringoma

Cellular components related to Malignant Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT15 KRT20 KRT7

Biological processes related to Malignant Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.13 KRT15 KRT20 KRT7
2 cornification GO:0070268 8.8 KRT15 KRT20 KRT7

Molecular functions related to Malignant Syringoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 KRT15 KRT20

Sources for Malignant Syringoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....