MCID: MLG081
MIFTS: 47

Malignant Teratoma

Categories: Cancer diseases, Fetal diseases

Aliases & Classifications for Malignant Teratoma

MalaCards integrated aliases for Malignant Teratoma:

Name: Malignant Teratoma 12 15
Primary Malignant Extragonadal Teratoma 12
Malignant Extragonadal Teratoma 12
Immature Extragonadal Teratoma 73
Teratoma, Malignant 73
Immature Teratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5563
MeSH 44 D013724
NCIt 50 C4286 C8884
SNOMED-CT 68 19467007

Summaries for Malignant Teratoma

Disease Ontology : 12 A teratoma that is cancerous.

MalaCards based summary : Malignant Teratoma, also known as primary malignant extragonadal teratoma, is related to teratoma and ovarian germ cell cancer. An important gene associated with Malignant Teratoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Apoptosis Pathway and DNA Damage Response. The drugs Cisplatin and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include testis, thyroid and ovary, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Malignant Teratoma

Diseases in the Teratoma family:

Malignant Teratoma Adult Teratoma
Intermediate Malignant Teratoma

Diseases related to Malignant Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 243)
# Related Disease Score Top Affiliating Genes
1 teratoma 30.5 AFP ENO2 POU5F1 SYP TP53
2 ovarian germ cell cancer 30.2 AFP SALL4
3 ovarian embryonal carcinoma 30.0 AFP POU5F1
4 seminoma 30.0 AFP ENO2 POU5F1
5 dysgerminoma 29.9 AFP ENO2
6 olfactory neuroblastoma 29.8 ENO2 SYP
7 endodermal sinus tumor 29.8 AFP SALL4
8 mature teratoma 29.5 AFP POU5F1 TP53
9 small cell carcinoma 29.5 ENO2 SYP TP53
10 oligodendroglioma 29.5 ENO2 SYP TP53
11 childhood immature teratoma of ovary 12.5
12 intermediate malignant teratoma 12.4
13 adult central nervous system immature teratoma 12.3
14 childhood central nervous system immature teratoma 12.3
15 pineal region immature teratoma 12.3
16 malignant gastric teratoma 11.7
17 sacrococcygeal teratoma 11.5
18 immature teratoma of ovary 11.3
19 central nervous system immature teratoma 11.1
20 gliomatosis peritonei 10.4
21 progressive multifocal leukoencephalopathy 10.3 BAX BCL2
22 kashin-beck disease 10.2 BAX BCL2
23 dysgerminoma of ovary 10.2 AFP ENO2
24 melanotic medulloblastoma 10.2 AFP ENO2
25 ovary adenocarcinoma 10.2 BAX TP53
26 head injury 10.2 BCL2 ENO2
27 keratocystic odontogenic tumor 10.2 BCL2 TP53
28 rete testis adenocarcinoma 10.2 AFP ENO2
29 acinar cell carcinoma 10.2 AFP TP53
30 cartilage-hair hypoplasia 10.2 BAX BCL2
31 muscle cancer 10.2 ENO2 TP53
32 juvenile pilocytic astrocytoma 10.2 ENO2 TP53
33 extragonadal germ cell cancer 10.2 AFP POU5F1
34 bile duct adenocarcinoma 10.1 AFP TP53
35 embryonal testis carcinoma 10.1 AFP POU5F1
36 encephalitis 10.1
37 mixed germ cell tumor 10.1
38 intratubular embryonal carcinoma 10.1 AFP POU5F1
39 cervical carcinosarcoma 10.1 BCL2 TP53
40 scrotal carcinoma 10.1 AFP TP53
41 testicular torsion 10.1 BCL2 TP53
42 testicular infarct 10.1 AFP POU5F1
43 rete testis neoplasm 10.1 AFP ENO2
44 ovarian endodermal sinus tumor 10.1 AFP SALL4
45 tuberculous epididymitis 10.1 AFP AVP
46 central pontine myelinolysis 10.1 AVP BCL2
47 alk-negative anaplastic large cell lymphoma 10.1 BAX BCL2
48 supraglottis cancer 10.1 ENO2 TP53
49 oculomotor nerve paralysis 10.1 AFP AVP
50 third cranial nerve disease 10.1 AFP AVP

Graphical network of the top 20 diseases related to Malignant Teratoma:



Diseases related to Malignant Teratoma

Symptoms & Phenotypes for Malignant Teratoma

GenomeRNAi Phenotypes related to Malignant Teratoma according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-106 9.74 BCL2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.74 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-12 9.74 TP53
4 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.74 AFP BCL2 TP53
5 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.74 BCL2
6 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.74 TP53
7 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.74 BCL2
8 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.74 TP53
9 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.74 BCL2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-19 9.74 TP53
11 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.74 TP53
12 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.74 AFP
13 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.74 BCL2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.74 BCL2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.74 BCL2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.74 AFP
17 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.74 TP53
18 Increased shRNA abundance (Z-score > 2) GR00366-A-37 9.74 BCL2
19 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.74 TP53
20 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.74 AFP
21 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.74 BCL2
22 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.74 BCL2
23 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.74 BCL2
24 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.74 BCL2

MGI Mouse Phenotypes related to Malignant Teratoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.91 AFP AVP BAX BCL2 ENO2 POU5F1
2 nervous system MP:0003631 9.76 AVP BAX BCL2 ENO2 POU5F1 SALL4
3 renal/urinary system MP:0005367 9.35 AVP BAX BCL2 SALL4 TP53
4 reproductive system MP:0005389 9.1 AFP BAX BCL2 POU5F1 SALL4 TP53

Drugs & Therapeutics for Malignant Teratoma

Drugs for Malignant Teratoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 93)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
2
Bleomycin Approved, Investigational Phase 3,Phase 2 11056-06-7 5360373
3
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
4
Vinblastine Approved Phase 3 865-21-4 241903 13342
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
7
Paclitaxel Approved, Vet_approved Phase 3,Phase 2,Phase 1 33069-62-4 36314
8
Oxaliplatin Approved, Investigational Phase 3 61825-94-3 43805 6857599 5310940 9887054
9
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1 51-75-2 4033
10
Lenograstim Approved, Investigational Phase 2, Phase 3,Phase 1 135968-09-1
11
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
12
Captopril Approved Phase 3 62571-86-2 44093
13
Ribavirin Approved Phase 3 36791-04-5 37542
14
Palivizumab Approved, Investigational Phase 3 188039-54-5
15
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
16
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
17
Itraconazole Approved, Investigational Phase 3 84625-61-6 55283
18
Caspofungin Approved Phase 3 179463-17-3, 162808-62-0 468682 2826718
19
Amphotericin B Approved, Investigational Phase 3 1397-89-3 5280965 14956
20
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
21 Etoposide phosphate Phase 3,Phase 2
22 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
23 Alkylating Agents Phase 3,Phase 2,Phase 1
24 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
26 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
27 Antimitotic Agents Phase 3,Phase 2,Phase 1
28 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
29 Albumin-Bound Paclitaxel Phase 3,Phase 2,Phase 1
30 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2,Phase 1
31 Hormones Phase 3,Phase 2,Phase 1
32 Hormone Antagonists Phase 3,Phase 2,Phase 1
33 Antihypertensive Agents Phase 3
34 Immunologic Factors Phase 3,Phase 2,Phase 1
35
protease inhibitors Phase 3
36 Antirheumatic Agents Phase 3
37 HIV Protease Inhibitors Phase 3
38 Immunosuppressive Agents Phase 3,Phase 1,Phase 2
39 Angiotensin-Converting Enzyme Inhibitors Phase 3
40 Immunoglobulins Phase 3,Phase 1
41 Antimetabolites Phase 3
42 Antibodies Phase 3,Phase 1
43 Anti-Infective Agents Phase 3,Phase 2
44 Antibodies, Monoclonal Phase 3,Phase 1
45 Antiviral Agents Phase 3,Phase 2
46 Cytochrome P-450 CYP2C9 Inhibitors Phase 3
47 Cytochrome P-450 CYP3A Inhibitors Phase 3
48 Steroid Synthesis Inhibitors Phase 3
49 Cytochrome P-450 Enzyme Inhibitors Phase 3
50
Hydroxyitraconazole Phase 3

Interventional clinical trials:

(show all 32)
# Name Status NCT ID Phase Drugs
1 Observation and/or Combination Chemotherapy After Surgery or Biopsy in Treating Young Patients With Extracranial Germ Cell Tumors Unknown status NCT00274950 Phase 3 carboplatin;cisplatin;etoposide;ifosfamide;vinblastine sulfate
2 Combination Chemotherapy in Treating Patients With Stage II or Stage III Germ Cell Tumors Unknown status NCT00104676 Phase 3 cisplatin;etoposide;ifosfamide;oxaliplatin;paclitaxel
3 Combination Chemotherapy in Treating Men With Germ Cell Cancer Unknown status NCT00003643 Phase 2, Phase 3 cisplatin;etoposide;paclitaxel
4 Captopril in Treating Patients Undergoing Bone Marrow or Stem Cell Transplantation Completed NCT00004230 Phase 3 captopril;cyclophosphamide
5 Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation Completed NCT00014391 Phase 3 ribavirin
6 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
7 Caspofungin Acetate Compared With Amphotericin B Liposomal in Treating Patients With Persistent Fever and Neutropenia Following Cancer Treatment Completed NCT00008359 Phase 3 caspofungin acetate;liposomal amphotericin B
8 Liposomal Amphotericin B in Treating Granulocytopenia and Persistent Unexplained Fever in Cancer Patients Completed NCT00003938 Phase 3 liposomal amphotericin B
9 Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors Recruiting NCT03067181 Phase 3 Bleomycin;Carboplatin;Cisplatin;Etoposide
10 Cisplatin and Ifosfamide Combined With Either Paclitaxel or Vinblastine in Treating Men With Progressive or Recurrent Metastatic Germ Cell Tumors Terminated NCT00072215 Phase 3 cisplatin;ifosfamide;paclitaxel;vinblastine
11 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
12 Sunitinib in Treating Patients With Metastatic Germ Cell Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00453310 Phase 2 sunitinib malate
13 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
14 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
15 Combination Chemotherapy and Pegfilgrastim in Treating Men With Metastatic Germ Cell Tumors Completed NCT00453232 Phase 2 cisplatin;etoposide
16 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
17 Combination Chemotherapy in Treating Male Patients With Germ Cell Tumors Completed NCT00301782 Phase 2 carboplatin;cisplatin;etoposide phosphate;vincristine sulfate
18 Immunotherapy in Treating Patients Who Are Undergoing Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00002673 Phase 2
19 Lymphocyte Infusion in Treating Patients With Relapsed Cancer After Bone Marrow or Peripheral Stem Cell Transplantation Completed NCT00003887 Phase 2
20 Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon Completed NCT00010283 Phase 1, Phase 2 beclomethasone dipropionate
21 Interleukin-11 Plus Filgrastim Prior to Peripheral Stem Cell Transplantation in Patients With Non-Hodgkin's Lymphoma, Hodgkin's Disease, Breast Cancer, or Other Solid Tumors Completed NCT00004157 Phase 2
22 Biological Therapy Following Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Cancer Completed NCT00003408 Phase 2
23 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
24 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
25 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
26 Ipilimumab After Allogeneic Stem Cell Transplant in Treating Patients With Persistent or Progressive Cancer Completed NCT00060372 Phase 1 ipilimumab;therapeutic allogeneic lymphocytes
27 Interleukin-12 in Treating Patients With Hematologic Cancers or Solid Tumors Completed NCT00003107 Phase 1
28 Liposomal Doxorubicin in Treating Children With Refractory Solid Tumors Completed NCT00019630 Phase 1 doxorubicin HCl liposome
29 Anterior Mediastinum Teratoma: A Case Report Completed NCT00836121
30 Acupuncture in Treating Mucositis-Related Pain Caused by Chemotherapy in Patients Undergoing Stem Cell Transplantation Completed NCT00060021 Not Applicable
31 Standard Follow-up Compared With Extended Follow-up in Treating Patients Who Have Undergone Stem Cell Transplantation for Cancer Completed NCT00049465 Not Applicable
32 Project: Every Child for Younger Patients With Cancer Recruiting NCT02402244

Search NIH Clinical Center for Malignant Teratoma

Genetic Tests for Malignant Teratoma

Anatomical Context for Malignant Teratoma

MalaCards organs/tissues related to Malignant Teratoma:

41
Testis, Thyroid, Ovary, Brain, Lung, Liver, Myeloid

Publications for Malignant Teratoma

Articles related to Malignant Teratoma:

(show top 50) (show all 156)
# Title Authors Year
1
Radiological-pathological correlation of malignant teratoma with liposarcomatous transformation: Proven by repeated transthoracic needle biopsy. ( 29106050 )
2018
2
Malignant teratoma in Klippel-Feil syndrome: a case report and review of the literature. ( 26438353 )
2015
3
Pathology in practice. Malignant teratoma of the left ovary of a mouse. ( 24984129 )
2014
4
Chemoresponsive liver hemangioma in a patient with metastatic malignant teratoma. ( 25168798 )
2014
5
Primary malignant teratoma of lung: report of a case and review of the literature. ( 22180529 )
2012
6
Unusual presentation of fetus-in-fetu mimicking malignant teratoma. ( 21922882 )
2011
7
Malignant teratoma of the thyroid in a pregnant woman. ( 20637432 )
2010
8
[Inhibitory effect of matrine on proliferation of human ovary malignant teratoma cell line PA-1 in vitro]. ( 20929131 )
2010
9
What is your diagnosis? Peritoneal fluid from a 1-year-old female German Shepherd dog. Malignant teratoma. ( 20561318 )
2010
10
Primary malignant teratoma of the thyroid in a child with nodal metastases. ( 19332924 )
2009
11
Case report: malignant teratoma of the uterine corpus. ( 19538751 )
2009
12
Successful pregnancy after treatment for ovarian malignant teratoma with growing teratoma syndrome. ( 19152879 )
2009
13
Cystic malignant teratoma with early recurrence after intraoperative spillage. ( 19022022 )
2008
14
Metastatic malignant teratoma arising from mediastinal nonseminomatous germ cell tumor: a case report. ( 18472634 )
2008
15
Primary malignant teratoma with a primitive neuroectodermal tumor component in thyroid gland: a case report. ( 17596674 )
2007
16
Malignant teratoma vs. carcinoma with teratomatous elements, rather than metaplastic carcinoma. ( 17097879 )
2007
17
Malignant teratoma 32 years after treatment of germ cell tumor confined to testis. ( 16566989 )
2006
18
Malignant teratoma of the thyroid: case report. ( 17199442 )
2006
19
Gamma mode of infiltration associated with poor prognosis in malignant teratoma of the ovary: A case report. ( 15922442 )
2005
20
Case report: malignant teratoma of the sinonasal tract. ( 15368065 )
2005
21
Thyroid carcinoma arising from a sacrococcygeal mass: a malignant teratoma? ( 15307946 )
2004
22
Malignant teratoma of the thyroid: aggressive chemoradiation therapy is required after surgery. ( 12804109 )
2003
23
Malignant teratoma of the orbit: a clinicopathological study of a case. ( 14685907 )
2003
24
Malignant teratoma of the medulla oblongata in an adult male. ( 11810399 )
2001
25
Malignant teratoma of the thyroid with primitive neuroepithelial and mesenchymal sarcomatous components. ( 11598856 )
2001
26
Malignant teratoma of the thyroid with predominantly neuroepithelial differentiation. Fine needle aspiration cytologic, histologic and immunocytochemical features of a case. ( 10833994 )
2000
27
Malignant teratoma of the thyroid: review of literature and report of a case. ( 10758996 )
2000
28
Malignant teratoma of the lung. ( 10665772 )
1999
29
Theriogenology question of the month. Malignant teratoma of the ovary. ( 10101408 )
1999
30
Primary malignant teratoma of the thyroid gland: report and discussion of two cases. ( 9744468 )
1998
31
Primary cervical malignant teratoma with a rib metastasis in an adult: five-year survival after surgery and chemotherapy. A case report with a review of the literature. ( 9818077 )
1998
32
Immature malignant teratoma of the thyroid gland. ( 9646244 )
1998
33
Malignant teratoma of the testis presenting with bilateral inguinal lymphadenopathy and diagnosed by fine needle aspiration (FNA). ( 9134338 )
1997
34
Retroperitoneal surgery: its wider role in the management of malignant teratoma. ( 8777620 )
1996
35
Case report: malignant teratoma in the thyroid gland. ( 8983598 )
1996
36
Primary pulmonary malignant teratoma with yolk sac element associated with hematologic neoplasia. ( 8833994 )
1996
37
Retroperitoneal malignant teratoma. A case report. ( 8935151 )
1995
38
Malignant teratoma of the testicle: diagnosis suggested by preoperative ultrasonography. ( 7502125 )
1995
39
Malignant teratoma undifferentiated (MTU) metastasising solely as differentiated teratoma: implications for the aetiology of residual differentiated disease following successful chemotherapy. ( 8562181 )
1995
40
Carcinoma in situ of the testis followed by an overt malignant teratoma of the testis within 12 months. ( 7980264 )
1994
41
Ifosfamide and carboplatin combined with 41.8 degrees C whole-body hyperthermia in patients with refractory sarcoma and malignant teratoma. ( 7923163 )
1994
42
Mediastinal malignant teratoma and acute myeloid leukemia in a patient with Klinefelter's syndrome--comparison of DNA content in the two malignancies. ( 7946452 )
1994
43
Malignant teratoma of the lung with lymph node metastasis of the ectodermal compartment: a case report. ( 8318068 )
1993
44
Management of malignant teratoma: does referral to a specialist unit matter? ( 8096954 )
1993
45
Prenatal diagnosis of intracranial teratoma. Prolonged survival after resection of a malignant teratoma diagnosed prenatally by ultrasound: a case report and literature review. ( 8382936 )
1993
46
Malignant teratoma arising in a dysgenetic gonad. ( 7690731 )
1993
47
Resection of an intracardiac metastasis from malignant teratoma of the testis. ( 8267441 )
1993
48
MRI detection of ruptured malignant teratoma in the third ventricle. ( 8492886 )
1993
49
Pilot study to evaluate impact of a policy of adjuvant chemotherapy for high risk stage 1 malignant teratoma on overall relapse rate of stage 1 cancer patients. ( 1279211 )
1992
50
Suprasellar malignant teratoma with 11-year survival--case report. ( 1383861 )
1992

Variations for Malignant Teratoma

Expression for Malignant Teratoma

Search GEO for disease gene expression data for Malignant Teratoma.

Pathways for Malignant Teratoma

Pathways related to Malignant Teratoma according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.21 BAX BCL2 TP53
2
Show member pathways
12.15 BAX BCL2 TP53
3 12.06 BAX BCL2 TP53
4
Show member pathways
12 BAX BCL2 TP53
5
Show member pathways
11.99 BAX BCL2 TP53
6 11.91 BAX BCL2 TP53
7 11.89 BAX BCL2 TP53
8
Show member pathways
11.78 BAX BCL2 TP53
9 11.74 BAX BCL2 TP53
10 11.71 BAX BCL2 TP53
11
Show member pathways
11.69 BAX BCL2 TP53
12 11.55 BAX BCL2 TP53
13 11.46 AFP BAX TP53
14 11.38 AFP BAX BCL2 TP53
15 11.36 BAX BCL2 TP53
16 11.21 BAX TP53
17 11.18 BAX TP53
18 11.14 BAX BCL2 TP53
19 11.1 BAX BCL2
20 11.04 BAX BCL2
21 10.99 BAX BCL2 TP53
22 10.93 BAX BCL2
24 10.82 BAX BCL2
25 10.43 BAX BCL2
26
Show member pathways
10.14 BAX BCL2 TP53

GO Terms for Malignant Teratoma

Cellular components related to Malignant Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pore complex GO:0046930 8.62 BAX BCL2

Biological processes related to Malignant Teratoma according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.93 AVP BAX BCL2 TP53
2 regulation of apoptotic process GO:0042981 9.82 BAX BCL2 TP53
3 cellular response to glucose starvation GO:0042149 9.65 BCL2 TP53
4 ovarian follicle development GO:0001541 9.65 BAX BCL2
5 response to nicotine GO:0035094 9.65 AVP BCL2
6 neuron apoptotic process GO:0051402 9.64 BAX BCL2
7 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.63 BAX BCL2
8 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.62 BAX BCL2
9 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 9.62 BAX BCL2
10 negative regulation of fibroblast proliferation GO:0048147 9.61 BAX TP53
11 homeostasis of number of cells within a tissue GO:0048873 9.61 BAX BCL2
12 intrinsic apoptotic signaling pathway GO:0097193 9.6 BAX TP53
13 cell aging GO:0007569 9.59 BCL2 TP53
14 positive regulation of release of cytochrome c from mitochondria GO:0090200 9.58 BAX TP53
15 regulation of mitochondrial membrane potential GO:0051881 9.58 BAX BCL2
16 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.57 BAX TP53
17 negative regulation of apoptotic signaling pathway GO:2001234 9.56 BAX BCL2
18 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.55 BCL2 TP53
19 B cell homeostasis GO:0001782 9.54 BAX BCL2
20 apoptotic mitochondrial changes GO:0008637 9.52 BAX BCL2
21 release of cytochrome c from mitochondria GO:0001836 9.51 BAX BCL2
22 cellular response to organic substance GO:0071310 9.5 BAX BCL2 SYP
23 positive regulation of protein oligomerization GO:0032461 9.49 BAX TP53
24 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.48 BAX BCL2
25 regulation of mitochondrial membrane permeability GO:0046902 9.46 BCL2 TP53
26 regulation of protein heterodimerization activity GO:0043497 9.43 BAX BCL2
27 regulation of protein homodimerization activity GO:0043496 9.4 BAX BCL2
28 leukocyte homeostasis GO:0001776 9.37 BAX BCL2
29 positive regulation of developmental pigmentation GO:0048087 9.26 BAX BCL2
30 regulation of nitrogen utilization GO:0006808 9.16 BAX BCL2
31 positive regulation of intrinsic apoptotic signaling pathway GO:2001244 9.13 BAX BCL2 TP53
32 response to gamma radiation GO:0010332 8.8 BAX BCL2 TP53

Molecular functions related to Malignant Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 channel activity GO:0015267 9.16 BAX BCL2
2 protein phosphatase 2A binding GO:0051721 8.96 BCL2 TP53
3 BH3 domain binding GO:0051434 8.62 BAX BCL2

Sources for Malignant Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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