MCID: MLG081
MIFTS: 37

Malignant Teratoma

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Malignant Teratoma

MalaCards integrated aliases for Malignant Teratoma:

Name: Malignant Teratoma 12 15
Primary Malignant Extragonadal Teratoma 12
Malignant Extragonadal Teratoma 12
Immature Extragonadal Teratoma 70
Teratoma, Malignant, Nos 12
Teratoma, Malignant 70
Immature Teratoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5563
MeSH 44 D013724
NCIt 50 C4286 C8884
SNOMED-CT 67 189847002
UMLS 70 C0334520 C0855163

Summaries for Malignant Teratoma

Disease Ontology : 12 A teratoma that is cancerous.

MalaCards based summary : Malignant Teratoma, also known as primary malignant extragonadal teratoma, is related to intermediate malignant teratoma and immature teratoma of ovary. An important gene associated with Malignant Teratoma is CD99 (CD99 Molecule (Xg Blood Group)), and among its related pathways/superpathways are Mesodermal Commitment Pathway and Wnt / Hedgehog / Notch. Affiliated tissues include testis, ovary and pineal.

Wikipedia : 73 An immature teratoma is a teratoma that contains anaplastic immature elements, and is often synonymous... more...

Related Diseases for Malignant Teratoma

Diseases in the Teratoma family:

Benign Teratoma Malignant Teratoma
Adult Teratoma Intermediate Malignant Teratoma

Diseases related to Malignant Teratoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
# Related Disease Score Top Affiliating Genes
1 intermediate malignant teratoma 32.6 TNFRSF8 AFP
2 immature teratoma of ovary 32.3 CEACAM5 AFP
3 mixed germ cell tumor 30.9 KIT AFP
4 nonseminomatous germ cell tumor 30.6 CGB5 AFP
5 obstructive hydrocephalus 30.3 SYP ENO2 AFP
6 head injury 30.3 ENO2 BCL2
7 ovarian mixed germ cell neoplasm 30.2 KIT CEACAM5 AFP
8 gonadoblastoma 30.2 POU5F1 KIT CGB5
9 cystic teratoma 30.1 SYP KIT ENO2
10 adrenal neuroblastoma 30.1 SYP ENO2
11 olfactory neuroblastoma 30.0 SYP ENO2 CD99
12 gonadal dysgenesis 29.9 POU5F1 KIT CGB5
13 ovarian germ cell teratoma 29.9 SYP MIR302C AFP
14 small cell carcinoma 29.9 SYP KIT ENO2
15 meckel diverticulum 29.8 SYP KIT
16 embryonal sarcoma 29.8 KIT GPC3
17 ovarian endodermal sinus tumor 29.6 SALL4 POU5F1 GPC3 AFP
18 ependymoblastoma 29.5 SYP MIR371A ENO2
19 teratoma 29.5 SYP SOX2 POU5F1 KIT GPC3 ENO2
20 rhabdomyosarcoma 29.5 SYP KIT GPC3 ENO2 CD99
21 testicular germ cell tumor 29.5 MIR371A KIT BAX AFP
22 benign teratoma 29.4 SYP SALL4 ENO2 CEACAM5 AFP
23 ovarian embryonal carcinoma 29.4 TNFRSF8 POU5F1 GPC3 AFP
24 medulloblastoma 29.3 SYP SOX2 POU5F1 NANOG KIT ENO2
25 germinoma 29.3 SALL4 POU5F1 MIR371A KIT CGB5 AFP
26 embryonal carcinoma 29.2 TNFRSF8 SOX2 POU5F1 NANOG KIT CGB5
27 dysgerminoma 29.2 SALL4 MIR371A MIR302C KIT ENO2 AFP
28 ovarian germ cell cancer 29.2 SYP SALL4 MIR302C KIT GPC3 CEACAM5
29 ewing sarcoma 28.9 TNFRSF8 SYP SOX2 KIT ENO2 CD99
30 seminoma 28.8 TNFRSF8 SOX2 POU5F1 NANOG KIT ENO2
31 endodermal sinus tumor 28.3 TNFRSF8 SALL4 MIR371A MIR302C GPC3 CGB5
32 germ cell cancer 28.2 SOX2 SALL4 POU5F1 NANOG MIR371A MIR302C
33 mature teratoma 27.5 TNFRSF8 SYP SALL4 POU5F1 NANOG MIR371A
34 childhood immature teratoma of ovary 11.5
35 malignant gastric teratoma 11.3
36 adult central nervous system immature teratoma 11.3
37 childhood central nervous system immature teratoma 11.3
38 pineal region immature teratoma 11.3
39 central nervous system immature teratoma 11.0
40 gliomatosis peritonei 10.5
41 kashin-beck disease 10.4 BCL2 BAX
42 gonadal germ cell tumor 10.4 CGB5 AFP
43 extragonadal germ cell cancer 10.4 CGB5 AFP
44 retroperitoneal neuroblastoma 10.4 ENO2 CD99
45 choriocarcinoma of the testis 10.4 SALL4 AFP
46 absolute glaucoma 10.4 BCL2 BAX
47 thymic epithelial tumor 10.4 KIT CD99
48 corpus luteum cyst 10.4 CGB5 AFP
49 ewing sarcoma of bone 10.4 ENO2 CD99
50 testicular fibroma 10.3 CD99 AFP

Graphical network of the top 20 diseases related to Malignant Teratoma:



Diseases related to Malignant Teratoma

Symptoms & Phenotypes for Malignant Teratoma

Drugs & Therapeutics for Malignant Teratoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Differences Between Gonadal and Extra-gonadal Malignant Teratomas in Both Genders and the Effects of Chemotherapy Completed NCT04555395
2 Immunohistochemical Evaluation of Protein P16 Expression in Ovarian Germ Cell Tumors. Recruiting NCT04283773

Search NIH Clinical Center for Malignant Teratoma

Genetic Tests for Malignant Teratoma

Anatomical Context for Malignant Teratoma

MalaCards organs/tissues related to Malignant Teratoma:

40
Testis, Ovary, Pineal, Lymph Node, Thymus, Thyroid, Bone Marrow

Publications for Malignant Teratoma

Articles related to Malignant Teratoma:

(show top 50) (show all 517)
# Title Authors PMID Year
1
A SEER database study of malignant teratomas in the head and neck region. 61
33740550 2021
2
Transcallosal-lateral ventricle-choroid fissure approach for excising large pineal region tumors extending into the third ventricle: experience in 15 pediatric cases. 61
32588176 2021
3
Cervical malignant teratoma masquerading as a hematoma: a case report. 61
33530806 2021
4
Clinicopathological Features, Prognostic Factors, Survival Trends, and Treatment of Malignant Ovarian Germ Cell Tumors: A SEER Database Analysis. 61
33706324 2021
5
Prevalence, clinical features and prognosis of malignant solid tumors in infants: a 14-year study. 61
33259778 2020
6
Coexistence of the BRCA1 and KRAS mutations in a patient with salivary gland carcinoma arising in mediastinal mature teratoma. 61
32796407 2020
7
Malignant teratomas of the thyroid gland: clinico-radiologic and cytomorphologic features of a rare entity. 61
32448730 2020
8
Ectopic thymoma: Retrospective analysis of eight cases with clinical features and computed tomography findings. 61
31927170 2020
9
Treatment and survival of primary intracranial germ cell tumors: a population-based study using SEER database. 61
31745701 2020
10
Malignant teratoma of the thyroid: A difficult diagnosis by fine-needle aspiration. 61
31120625 2019
11
[Application of pedicled anterolateral thigh myocutaneous flap for full-thickness abdominal wall reconstruction after tumor resection]. 61
31197998 2019
12
Descriptive epidemiology of germ cell tumors of the central nervous system diagnosed in the United States from 2006 to 2015. 61
31025275 2019
13
The differences between gonadal and extra-gonadal malignant teratomas in both genders and the effects of chemotherapy. 61
31039746 2019
14
CFTR constrains the differentiation from mouse embryonic stem cells to intestine lineage cells. 61
30704755 2019
15
Huge right ventricular mass revealing a testicular nonseminomatous germ cell tumor. 61
29983504 2018
16
Malignant transformation in mature cystic teratoma of the ovary: a retrospective study of eight cases and review of literature. 61
30150913 2018
17
Tumour lysis in newborn: spontaneous or secondary to antenatal steroids? 61
29618468 2018
18
A Case of Malignant Melanoma Arising in Mediastinal Malignant Teratoma. 61
30693128 2018
19
Radiological-pathological correlation of malignant teratoma with liposarcomatous transformation: Proven by repeated transthoracic needle biopsy. 61
29106050 2018
20
Malignant orbital teratoma in a neonate: A clinicopathological case report. 61
28695872 2017
21
Abscessed Inguinal Metastasis of Testicular Tumor. Case Report. 61
28271048 2017
22
Analysis of treatment of large abdominal malignancies in children complicated with abdominal compartment syndrome: Report of six cases. 61
28445278 2017
23
Sinonasal teratocarcinosarcoma involving nasal cavity, nasopharynx, and all paranasal sinuses with bilateral orbital and intracranial extension: A rare case report. 61
28484539 2017
24
[Intracranial mixed germ cell tumor]. 61
28297824 2017
25
[Application of vascular repair and reconstruction in surgical treatment of superior vena cava syndrome caused by thoracic tumor]. 61
29786259 2017
26
[Malignant teratoma: about a case and a review of the literature]. 61
28819483 2017
27
Diagnosis and surgical management of malignant ovarian teratoma in a green iguana (Iguana iguana). 61
27435282 2016
28
Increased 99mTc-MDP Activity in a Partially Calcified Malignant Mediastinal Teratoma. 61
26562576 2016
29
Malignant teratoma in Klippel-Feil syndrome: a case report and review of the literature. 61
26438353 2015
30
The prognosis of osteosarcoma occurring as second malignancy of childhood cancers may be favorable: experience of two cancer centers in Japan. 61
25022788 2015
31
Testicular Nodules Suspected for Malignancy. Does the Pathologist Make the Difference for Organ-Sparing Surgery? . 61
26173351 2015
32
Squamous cell carcinoma arising in a mature cystic teratoma invading the sigmoid colon: a rare presentation. 61
25935913 2015
33
Spectrum of ovarian tumors: Histopathological study of 218 cases. 61
26003107 2015
34
Chemoresponsive liver hemangioma in a patient with metastatic malignant teratoma. 61
25168798 2015
35
Imaging characteristics of primary intracranial teratoma. 61
24103916 2014
36
Complete resection of a giant mediastinal teratoma occupying the entire right hemithorax in a 14-year-old boy. 61
25151139 2014
37
Pathology in practice. Malignant teratoma of the left ovary of a mouse. 61
24984129 2014
38
[Sinonasal teratocarcinosarcoma]. 61
25046074 2014
39
Dermoid Cyst and its bizarre presentation. 61
26905716 2014
40
A rare case of postmenopausal immature teratoma with a recurrent grave course. 61
24955203 2014
41
Malignant ovarian germ cell tumors: presentation, survival and second cancer in a population based Norwegian cohort (1953-2009). 61
24001518 2013
42
Malignant thyroid teratoma: report of an aggressive tumor in a 64-year-old man. 61
23702575 2013
43
Survival after a diagnosis of testicular germ cell cancers in Germany and the United States, 2002-2006: a high resolution study by histology and age. 61
23623488 2013
44
Anterior callosal section is useful for the removal of large tumors invading the dorsal part of the anterior third ventricle: operative technique and results. 61
23568695 2013
45
Spinal cord compression in childhood pediatric malignancies: multicenter egyptian study. 61
23511492 2013
46
[A case of mediastinum malignant teratoma which recurred as bone metastases seven years after a resection, and survived for a long-duration]. 61
23507610 2013
47
Ovarian cysts and tumors in infancy and childhood. 61
23599577 2013
48
CDX-2 expression in malignant germ cell tumors of the testes, intratubular germ cell neoplasia, and normal seminiferous tubules. 61
22895825 2012
49
Primary malignant teratoma of lung: report of a case and review of the literature. 61
22180529 2012
50
Mediastinal germ cell tumors in childhood. 61
22877235 2012

Variations for Malignant Teratoma

Expression for Malignant Teratoma

Search GEO for disease gene expression data for Malignant Teratoma.

Pathways for Malignant Teratoma

GO Terms for Malignant Teratoma

Cellular components related to Malignant Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pore complex GO:0046930 8.62 BCL2 BAX

Biological processes related to Malignant Teratoma according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.85 SOX2 NANOG KIT BCL2
2 male gonad development GO:0008584 9.73 KIT BCL2 BAX
3 response to wounding GO:0009611 9.69 SOX2 POU5F1 BAX
4 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.58 BCL2 BAX
5 stem cell population maintenance GO:0019827 9.58 SALL4 NANOG KIT
6 apoptotic mitochondrial changes GO:0008637 9.57 BCL2 BAX
7 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.54 SOX2 BAX
8 ovarian follicle development GO:0001541 9.54 KIT BCL2 BAX
9 developmental pigmentation GO:0048066 9.52 KIT BCL2
10 cellular response to organic substance GO:0071310 9.5 SYP BCL2 BAX
11 homotypic cell-cell adhesion GO:0034109 9.49 CEACAM5 CD99
12 leukocyte homeostasis GO:0001776 9.48 BAX BCL2
13 lymphoid progenitor cell differentiation GO:0002320 9.46 BCL2 KIT
14 ectopic germ cell programmed cell death GO:0035234 9.43 BAX KIT
15 positive regulation of developmental pigmentation GO:0048087 9.26 BCL2 BAX
16 regulation of nitrogen utilization GO:0006808 9.16 BCL2 BAX
17 endodermal cell fate specification GO:0001714 9.13 SOX2 POU5F1 NANOG
18 somatic stem cell population maintenance GO:0035019 9.02 SOX2 SALL4 POU5F1 NANOG KIT

Molecular functions related to Malignant Teratoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BH3 domain binding GO:0051434 8.62 BCL2 BAX

Sources for Malignant Teratoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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